CDH8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.76022093
2vocalization behavior (GO:0071625)5.23047269
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.22664854
4neuron cell-cell adhesion (GO:0007158)5.20249219
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.14506074
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.11081122
7ionotropic glutamate receptor signaling pathway (GO:0035235)5.03980754
8synaptic vesicle exocytosis (GO:0016079)4.92019618
9pyrimidine nucleobase catabolic process (GO:0006208)4.91374568
10regulation of glutamate receptor signaling pathway (GO:1900449)4.86120146
11protein localization to synapse (GO:0035418)4.84062976
12locomotory exploration behavior (GO:0035641)4.81746809
13synaptic vesicle maturation (GO:0016188)4.73584523
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.69239107
15regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.69143431
16regulation of synaptic vesicle exocytosis (GO:2000300)4.59379317
17glutamate receptor signaling pathway (GO:0007215)4.56355734
18presynaptic membrane assembly (GO:0097105)4.55889400
19* neuron-neuron synaptic transmission (GO:0007270)4.52100650
20glutamate secretion (GO:0014047)4.47382126
21presynaptic membrane organization (GO:0097090)4.44551961
22* synaptic transmission, glutamatergic (GO:0035249)4.43995527
23neurotransmitter-gated ion channel clustering (GO:0072578)4.27932313
24exploration behavior (GO:0035640)4.27697745
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.20903221
26negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.20260333
27positive regulation of synaptic transmission, GABAergic (GO:0032230)4.11682653
28regulation of synaptic vesicle transport (GO:1902803)4.10770084
29nucleobase catabolic process (GO:0046113)4.04570758
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.99656959
31postsynaptic membrane organization (GO:0001941)3.97616290
32neuron recognition (GO:0008038)3.95718796
33behavioral response to nicotine (GO:0035095)3.93032397
34neurotransmitter secretion (GO:0007269)3.88009209
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.87332376
36regulation of neuronal synaptic plasticity (GO:0048168)3.85892816
37gamma-aminobutyric acid signaling pathway (GO:0007214)3.85530101
38positive regulation of synapse maturation (GO:0090129)3.82583644
39response to histamine (GO:0034776)3.79074279
40regulation of synapse structural plasticity (GO:0051823)3.79002482
41regulation of postsynaptic membrane potential (GO:0060078)3.78751336
42long-term memory (GO:0007616)3.78742246
43neuronal action potential propagation (GO:0019227)3.75903802
44response to pheromone (GO:0019236)3.69900357
45prepulse inhibition (GO:0060134)3.62521994
46regulation of synaptic transmission, glutamatergic (GO:0051966)3.61933325
47positive regulation of membrane potential (GO:0045838)3.60134836
48layer formation in cerebral cortex (GO:0021819)3.59892940
49protein polyglutamylation (GO:0018095)3.59519605
50dendritic spine morphogenesis (GO:0060997)3.53238759
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.52595847
52membrane hyperpolarization (GO:0060081)3.49411480
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48372530
54axonal fasciculation (GO:0007413)3.46727225
55startle response (GO:0001964)3.46418381
56long-term synaptic potentiation (GO:0060291)3.46034280
57mating behavior (GO:0007617)3.44092214
58transmission of nerve impulse (GO:0019226)3.43669565
59auditory behavior (GO:0031223)3.39959854
60behavioral response to cocaine (GO:0048148)3.38058086
61synaptic vesicle endocytosis (GO:0048488)3.35227164
62behavioral fear response (GO:0001662)3.34105322
63behavioral defense response (GO:0002209)3.34105322
64synapse assembly (GO:0007416)3.33818418
65regulation of dopamine metabolic process (GO:0042053)3.33609373
66regulation of catecholamine metabolic process (GO:0042069)3.33609373
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33573080
68innervation (GO:0060384)3.33095252
69synaptic transmission, dopaminergic (GO:0001963)3.29978076
70righting reflex (GO:0060013)3.29558945
71gamma-aminobutyric acid transport (GO:0015812)3.26058912
72membrane depolarization (GO:0051899)3.24925705
73positive regulation of neurotransmitter secretion (GO:0001956)3.23798502
74activation of protein kinase A activity (GO:0034199)3.23311231
75regulation of synaptic plasticity (GO:0048167)3.22600228
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.22168635
77neurotransmitter transport (GO:0006836)3.21101569
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20981266
79regulation of dendritic spine morphogenesis (GO:0061001)3.20910345
80regulation of vesicle fusion (GO:0031338)3.18409932
81proline transport (GO:0015824)3.18139000
82neuronal action potential (GO:0019228)3.17956389
83fear response (GO:0042596)3.17189060
84response to auditory stimulus (GO:0010996)3.16089325
85positive regulation of synapse assembly (GO:0051965)3.15876655
86regulation of synaptic transmission, GABAergic (GO:0032228)3.13846255
87nonmotile primary cilium assembly (GO:0035058)3.12766616
88cellular potassium ion homeostasis (GO:0030007)3.09492840
89regulation of neurotransmitter secretion (GO:0046928)3.08326438
90mechanosensory behavior (GO:0007638)3.06082137
91positive regulation of neurotransmitter transport (GO:0051590)3.04916160
92striatum development (GO:0021756)3.04219239
93cerebellar Purkinje cell differentiation (GO:0021702)3.03102690
94glycosphingolipid biosynthetic process (GO:0006688)3.03061312
95dendrite morphogenesis (GO:0048813)3.03058014
96regulation of synapse maturation (GO:0090128)3.02236320
97learning (GO:0007612)3.01528866
98establishment of mitochondrion localization (GO:0051654)3.00405087
99regulation of neurotransmitter levels (GO:0001505)2.99806389
100protein localization to cilium (GO:0061512)2.99137249
101regulation of neurotransmitter transport (GO:0051588)2.96419617
102* synaptic transmission (GO:0007268)2.96061126
103regulation of glutamate secretion (GO:0014048)2.93932963
104central nervous system projection neuron axonogenesis (GO:0021952)2.93109667
105regulation of dopamine secretion (GO:0014059)2.92709033
106G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.91256245
107regulation of action potential (GO:0098900)2.91004312
108membrane depolarization during action potential (GO:0086010)2.90957855
109synapse organization (GO:0050808)2.90313868
110detection of calcium ion (GO:0005513)2.90200345
111positive regulation of synaptic transmission (GO:0050806)2.89649757
112adult walking behavior (GO:0007628)2.88872245
113neurofilament cytoskeleton organization (GO:0060052)2.87735154
114retinal ganglion cell axon guidance (GO:0031290)2.87072702
115short-term memory (GO:0007614)2.83234215
116serotonin metabolic process (GO:0042428)2.83194372
117reflex (GO:0060004)2.75915235
118behavioral response to ethanol (GO:0048149)2.75210855
119cell migration in hindbrain (GO:0021535)2.74299183
120acrosome reaction (GO:0007340)2.72227611
121detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.72119543
122epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.70116728
123epithelial cilium movement (GO:0003351)2.69271437
124central nervous system neuron axonogenesis (GO:0021955)2.69203073
125retinal cone cell development (GO:0046549)2.69045538
126primary amino compound metabolic process (GO:1901160)2.68796510
127neuromuscular synaptic transmission (GO:0007274)2.64190480
128positive regulation of dendritic spine morphogenesis (GO:0061003)2.63903962
129cerebral cortex radially oriented cell migration (GO:0021799)2.61992620
130adult behavior (GO:0030534)2.59029780
131inner ear receptor stereocilium organization (GO:0060122)2.55763221
132C4-dicarboxylate transport (GO:0015740)2.55167151
133tachykinin receptor signaling pathway (GO:0007217)2.55019394
134negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54084982
135positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.53264825
136calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.52688040
137regulation of synapse assembly (GO:0051963)2.51419862
138regulation of feeding behavior (GO:0060259)2.51378852
139regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.49734241
140regulation of cilium movement (GO:0003352)2.49663620
141calcium ion-dependent exocytosis (GO:0017156)2.48825281

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.87184780
2GBX2_23144817_ChIP-Seq_PC3_Human4.31309812
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06153890
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01201731
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98628566
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.64362582
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.61230570
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59453720
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54220141
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54220141
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53427816
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50442196
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39401434
14* EED_16625203_ChIP-ChIP_MESCs_Mouse2.38593151
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36968696
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35265415
17TAF15_26573619_Chip-Seq_HEK293_Human2.29486764
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.23358325
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20782254
20DROSHA_22980978_ChIP-Seq_HELA_Human2.20665680
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.18663141
22* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17931673
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15089680
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14719586
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.12449114
26* GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10015455
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.08892692
28* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02533244
29* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95740387
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83600869
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.79843250
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77811995
33* P300_19829295_ChIP-Seq_ESCs_Human1.71745746
34EWS_26573619_Chip-Seq_HEK293_Human1.71401850
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71095113
36* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70067072
37ZNF274_21170338_ChIP-Seq_K562_Hela1.68620256
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.67596566
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65688002
40IGF1R_20145208_ChIP-Seq_DFB_Human1.62372572
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61617312
42* CBX2_27304074_Chip-Seq_ESCs_Mouse1.55568523
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.54793122
44AR_21572438_ChIP-Seq_LNCaP_Human1.51910226
45* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51388357
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49727460
47* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48411691
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.46471428
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44839745
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44771741
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.43382430
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41649442
53* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40482517
54FUS_26573619_Chip-Seq_HEK293_Human1.38946773
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38719126
56CBP_20019798_ChIP-Seq_JUKART_Human1.38719126
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38234111
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35469120
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34928032
60AR_25329375_ChIP-Seq_VCAP_Human1.34320178
61* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32766016
62* STAT3_23295773_ChIP-Seq_U87_Human1.32642798
63* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30257211
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29190301
65RNF2_27304074_Chip-Seq_NSC_Mouse1.27538301
66* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25742870
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.25719741
68* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23843277
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23746524
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.19278893
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18628250
72* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18074439
73AR_19668381_ChIP-Seq_PC3_Human1.17646773
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16659025
75* TCF4_23295773_ChIP-Seq_U87_Human1.15811531
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15653968
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15535095
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13844641
79* VDR_22108803_ChIP-Seq_LS180_Human1.13027263
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12879455
81* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11846816
82RUNX2_22187159_ChIP-Seq_PCA_Human1.11022313
83ER_23166858_ChIP-Seq_MCF-7_Human1.10701124
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10421654
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.10291524
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09676585
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09263319
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08817369
89TCF4_22108803_ChIP-Seq_LS180_Human1.08349318
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08099176
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08077709
92* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07846245
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.07806225
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.07706228
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.07160851
96* TAL1_26923725_Chip-Seq_HPCs_Mouse1.07143466
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06464925
98AHR_22903824_ChIP-Seq_MCF-7_Human1.06260780
99IRF1_19129219_ChIP-ChIP_H3396_Human1.05258947
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05145481
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.04897423
102* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04047617
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02971137
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02952889
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02756751
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02084106
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02084106
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.01882456
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.01134159
110P53_22387025_ChIP-Seq_ESCs_Mouse1.00868297
111TP53_22573176_ChIP-Seq_HFKS_Human1.00494207
112WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99094947
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99089933
114* BCAT_22108803_ChIP-Seq_LS180_Human0.97441427
115JUN_21703547_ChIP-Seq_K562_Human0.96530583
116* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95062137
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.92656867
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91925963
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89917746
120* TP53_18474530_ChIP-ChIP_U2OS_Human0.88708650
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87893586
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87295328
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86825976
124* KDM2B_26808549_Chip-Seq_REH_Human0.85171849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.54501282
2MP0003880_abnormal_central_pattern5.45801090
3* MP0003635_abnormal_synaptic_transmissio3.93050179
4MP0004270_analgesia3.35212665
5MP0009745_abnormal_behavioral_response3.31670671
6MP0002063_abnormal_learning/memory/cond3.28020646
7MP0001968_abnormal_touch/_nociception2.98056888
8MP0002064_seizures2.94097097
9MP0002572_abnormal_emotion/affect_behav2.89295266
10MP0009046_muscle_twitch2.80769887
11MP0002822_catalepsy2.77992772
12MP0005423_abnormal_somatic_nervous2.75195847
13MP0002735_abnormal_chemical_nociception2.64102268
14MP0002272_abnormal_nervous_system2.52504473
15MP0001486_abnormal_startle_reflex2.51008355
16MP0002734_abnormal_mechanical_nocicepti2.43141130
17MP0002736_abnormal_nociception_after2.33365790
18MP0001440_abnormal_grooming_behavior2.19492331
19MP0002909_abnormal_adrenal_gland2.09287055
20MP0001529_abnormal_vocalization2.08818405
21MP0001501_abnormal_sleep_pattern2.07597398
22MP0006276_abnormal_autonomic_nervous2.03568422
23MP0002067_abnormal_sensory_capabilities2.01433010
24MP0009780_abnormal_chondrocyte_physiolo1.95425387
25MP0000778_abnormal_nervous_system1.89846202
26MP0001970_abnormal_pain_threshold1.89737370
27MP0002184_abnormal_innervation1.86174707
28* MP0002733_abnormal_thermal_nociception1.85064512
29MP0002557_abnormal_social/conspecific_i1.81258911
30MP0003787_abnormal_imprinting1.80488640
31MP0004924_abnormal_behavior1.79857265
32MP0005386_behavior/neurological_phenoty1.79857265
33MP0005646_abnormal_pituitary_gland1.71519275
34MP0004811_abnormal_neuron_physiology1.61817191
35MP0001188_hyperpigmentation1.61016245
36MP0003879_abnormal_hair_cell1.60908047
37MP0003136_yellow_coat_color1.60291938
38MP0001905_abnormal_dopamine_level1.54270444
39MP0008877_abnormal_DNA_methylation1.53740502
40MP0005645_abnormal_hypothalamus_physiol1.52703000
41MP0001984_abnormal_olfaction1.50547283
42MP0008569_lethality_at_weaning1.47219300
43MP0000955_abnormal_spinal_cord1.46008462
44MP0002653_abnormal_ependyma_morphology1.45659492
45MP0003122_maternal_imprinting1.44368065
46MP0003329_amyloid_beta_deposits1.43798566
47MP0001502_abnormal_circadian_rhythm1.42243746
48MP0000569_abnormal_digit_pigmentation1.41577738
49MP0000013_abnormal_adipose_tissue1.38425516
50MP0010386_abnormal_urinary_bladder1.37062901
51MP0002882_abnormal_neuron_morphology1.36620294
52* MP0002066_abnormal_motor_capabilities/c1.32608340
53MP0004133_heterotaxia1.30756008
54MP0004858_abnormal_nervous_system1.29668772
55MP0005551_abnormal_eye_electrophysiolog1.23830513
56MP0002837_dystrophic_cardiac_calcinosis1.21067980
57MP0004885_abnormal_endolymph1.17430667
58MP0003283_abnormal_digestive_organ1.17395011
59MP0000631_abnormal_neuroendocrine_gland1.17387824
60MP0003633_abnormal_nervous_system1.09963824
61MP0002152_abnormal_brain_morphology1.08288521
62MP0008789_abnormal_olfactory_epithelium1.06068451
63MP0004742_abnormal_vestibular_system1.02613111
64MP0002638_abnormal_pupillary_reflex1.01556334
65MP0002876_abnormal_thyroid_physiology1.01091988
66MP0006292_abnormal_olfactory_placode1.00916231
67MP0004142_abnormal_muscle_tone1.00600852
68MP0003890_abnormal_embryonic-extraembry0.98360769
69MP0003119_abnormal_digestive_system0.96950909
70MP0002069_abnormal_eating/drinking_beha0.95433579
71MP0000566_synostosis0.94253099
72MP0003631_nervous_system_phenotype0.92835506
73MP0002229_neurodegeneration0.91906177
74MP0005535_abnormal_body_temperature0.91712804
75MP0004043_abnormal_pH_regulation0.90497571
76MP0001986_abnormal_taste_sensitivity0.89591032
77MP0002938_white_spotting0.89170232
78MP0008872_abnormal_physiological_respon0.87937146
79MP0006072_abnormal_retinal_apoptosis0.87096248
80MP0005394_taste/olfaction_phenotype0.86702084
81MP0005499_abnormal_olfactory_system0.86702084
82MP0004085_abnormal_heartbeat0.86250178
83MP0005195_abnormal_posterior_eye0.83948960
84MP0001293_anophthalmia0.83388957
85MP0004145_abnormal_muscle_electrophysio0.81945673
86MP0003195_calcinosis0.81236453
87MP0001963_abnormal_hearing_physiology0.79481859
88MP0002752_abnormal_somatic_nervous0.79020243
89MP0000049_abnormal_middle_ear0.77360227
90MP0005171_absent_coat_pigmentation0.76821113
91MP0005409_darkened_coat_color0.76780902
92MP0002234_abnormal_pharynx_morphology0.76446791
93MP0000751_myopathy0.76144599
94MP0005377_hearing/vestibular/ear_phenot0.75122416
95MP0003878_abnormal_ear_physiology0.75122416
96MP0004147_increased_porphyrin_level0.72793989
97MP0001664_abnormal_digestion0.72088712
98MP0005248_abnormal_Harderian_gland0.71665582
99MP0002928_abnormal_bile_duct0.70500101
100MP0000427_abnormal_hair_cycle0.68886210
101MP0005379_endocrine/exocrine_gland_phen0.68332272
102MP0008874_decreased_physiological_sensi0.67370768
103MP0003634_abnormal_glial_cell0.66203267
104MP0004215_abnormal_myocardial_fiber0.65694552
105MP0002090_abnormal_vision0.65579490
106MP0003183_abnormal_peptide_metabolism0.65565997
107MP0005187_abnormal_penis_morphology0.65536423
108MP0001485_abnormal_pinna_reflex0.65086983
109MP0001177_atelectasis0.64296494
110MP0003632_abnormal_nervous_system0.63990513
111MP0008961_abnormal_basal_metabolism0.63536461
112MP0000026_abnormal_inner_ear0.59609744
113MP0005253_abnormal_eye_physiology0.59319482
114MP0003121_genomic_imprinting0.58985109
115MP0003861_abnormal_nervous_system0.57390270
116MP0002693_abnormal_pancreas_physiology0.54718384
117MP0001943_abnormal_respiration0.54623211
118MP0003137_abnormal_impulse_conducting0.53345624
119MP0002102_abnormal_ear_morphology0.51939495
120MP0002751_abnormal_autonomic_nervous0.51736556

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.69151202
2Focal seizures (HP:0007359)5.47488553
3Myokymia (HP:0002411)5.36205602
4Epileptic encephalopathy (HP:0200134)4.94306226
5Visual hallucinations (HP:0002367)4.84808945
6Atonic seizures (HP:0010819)4.65878884
7Febrile seizures (HP:0002373)4.49100596
8Absence seizures (HP:0002121)4.19044672
9Progressive cerebellar ataxia (HP:0002073)3.93256306
10Dialeptic seizures (HP:0011146)3.88963859
11Generalized tonic-clonic seizures (HP:0002069)3.75370411
12Hyperventilation (HP:0002883)3.74692443
13Broad-based gait (HP:0002136)3.57832750
14Limb dystonia (HP:0002451)3.50593220
15Pancreatic fibrosis (HP:0100732)3.23324379
16Epileptiform EEG discharges (HP:0011182)3.19776977
17Poor eye contact (HP:0000817)3.19192432
18Pancreatic cysts (HP:0001737)3.12849773
19True hermaphroditism (HP:0010459)3.12136849
20Gaze-evoked nystagmus (HP:0000640)3.11154402
21Drooling (HP:0002307)3.10754249
22Excessive salivation (HP:0003781)3.10754249
23EEG with generalized epileptiform discharges (HP:0011198)3.01921889
24Nephronophthisis (HP:0000090)2.97799321
25Impaired vibration sensation in the lower limbs (HP:0002166)2.97151899
26Ankle clonus (HP:0011448)2.93860269
27Truncal ataxia (HP:0002078)2.93376549
28Amblyopia (HP:0000646)2.86477539
29Impaired social interactions (HP:0000735)2.80196172
30Abnormal social behavior (HP:0012433)2.80196172
31Supranuclear gaze palsy (HP:0000605)2.77194930
32Hypsarrhythmia (HP:0002521)2.76544547
33Action tremor (HP:0002345)2.76422759
34Urinary bladder sphincter dysfunction (HP:0002839)2.74640645
35Anxiety (HP:0000739)2.73805631
36Depression (HP:0000716)2.73214125
37Molar tooth sign on MRI (HP:0002419)2.71745979
38Abnormality of midbrain morphology (HP:0002418)2.71745979
39Abnormality of the labia minora (HP:0012880)2.69578340
40Protruding tongue (HP:0010808)2.68021466
41Abnormal eating behavior (HP:0100738)2.64877880
42Dysdiadochokinesis (HP:0002075)2.60092064
43Scanning speech (HP:0002168)2.57979146
44Pheochromocytoma (HP:0002666)2.57390377
45Hemiparesis (HP:0001269)2.57200045
46Abnormality of the renal medulla (HP:0100957)2.53577459
47Lissencephaly (HP:0001339)2.53461269
48Mutism (HP:0002300)2.52254956
49Cerebral inclusion bodies (HP:0100314)2.51985895
50Absent speech (HP:0001344)2.51544273
51Abnormality of binocular vision (HP:0011514)2.49459352
52Diplopia (HP:0000651)2.49459352
53Impaired smooth pursuit (HP:0007772)2.46074390
54Stereotypic behavior (HP:0000733)2.44597721
55Dysmetria (HP:0001310)2.43884122
56Progressive inability to walk (HP:0002505)2.42837578
57Congenital stationary night blindness (HP:0007642)2.40464193
58Inability to walk (HP:0002540)2.40042741
59Agitation (HP:0000713)2.39824084
60Polyphagia (HP:0002591)2.38702186
61Gait imbalance (HP:0002141)2.35388754
62Spastic gait (HP:0002064)2.34515085
63Neurofibrillary tangles (HP:0002185)2.33667695
64Failure to thrive in infancy (HP:0001531)2.32833913
65Optic nerve hypoplasia (HP:0000609)2.32489249
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.32457823
67Genetic anticipation (HP:0003743)2.30478108
68Abnormality of the renal cortex (HP:0011035)2.29281533
69Bradykinesia (HP:0002067)2.24908264
70Oligodactyly (hands) (HP:0001180)2.21076620
71Postural instability (HP:0002172)2.19139241
72Neuroendocrine neoplasm (HP:0100634)2.18940485
73Fetal akinesia sequence (HP:0001989)2.17956436
74Torticollis (HP:0000473)2.17866315
75Poor coordination (HP:0002370)2.17428236
76Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.17129300
77Abnormality of ocular smooth pursuit (HP:0000617)2.14751928
78Urinary urgency (HP:0000012)2.12786816
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.12128032
80Pachygyria (HP:0001302)2.10691615
81Sclerocornea (HP:0000647)2.08430882
82Retinal dysplasia (HP:0007973)2.07269769
83Papilledema (HP:0001085)2.06300696
84Abnormality of salivation (HP:0100755)2.04420226
85Focal dystonia (HP:0004373)2.02805199
86Amyotrophic lateral sclerosis (HP:0007354)2.02734920
87Postaxial hand polydactyly (HP:0001162)2.02643793
88Abnormality of the lower motor neuron (HP:0002366)2.01870420
89Renal cortical cysts (HP:0000803)2.01028020
90Cystic liver disease (HP:0006706)1.99253255
91Abnormality of the corticospinal tract (HP:0002492)1.98300981
92Type II lissencephaly (HP:0007260)1.97632102
93Postaxial foot polydactyly (HP:0001830)1.95961278
94Blue irides (HP:0000635)1.95212462
95Morphological abnormality of the pyramidal tract (HP:0002062)1.94785332
96Broad foot (HP:0001769)1.92594867
97Impaired vibratory sensation (HP:0002495)1.92530413
98Lower limb muscle weakness (HP:0007340)1.91285960
99Chronic hepatic failure (HP:0100626)1.90998357
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.88316975
101Akinesia (HP:0002304)1.86009957
102Dyskinesia (HP:0100660)1.85686641
103Spastic tetraplegia (HP:0002510)1.85636564
104Craniofacial dystonia (HP:0012179)1.85000646
105Congenital primary aphakia (HP:0007707)1.84878660
106Septo-optic dysplasia (HP:0100842)1.84160547
107Termporal pattern (HP:0011008)1.83918332
108Insidious onset (HP:0003587)1.83918332
109Dysmetric saccades (HP:0000641)1.83699521
110Gait ataxia (HP:0002066)1.83280202
111Neoplasm of the heart (HP:0100544)1.83022513
112Short tibia (HP:0005736)1.81714271
113Medial flaring of the eyebrow (HP:0010747)1.81549918
114Anencephaly (HP:0002323)1.81526212
115Specific learning disability (HP:0001328)1.79625157
116Acute necrotizing encephalopathy (HP:0006965)1.78386832
117Incomplete penetrance (HP:0003829)1.78156156
118Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77206619
119Degeneration of the lateral corticospinal tracts (HP:0002314)1.77206619
120Status epilepticus (HP:0002133)1.77122581
121Short foot (HP:0001773)1.75187529
122Abnormality of calcium-phosphate metabolism (HP:0100530)1.74989195
123Generalized myoclonic seizures (HP:0002123)1.74821530
124Megalencephaly (HP:0001355)1.74681715
125Hypoplasia of the brainstem (HP:0002365)1.74365190
126Aplasia/Hypoplasia of the brainstem (HP:0007362)1.74365190
127Intention tremor (HP:0002080)1.73747504
128Decreased circulating renin level (HP:0003351)1.73575743
129Hypoventilation (HP:0002791)1.73072098
130Hypothermia (HP:0002045)1.72971117
131Vaginal atresia (HP:0000148)1.72298459
132Genital tract atresia (HP:0001827)1.72054840
133Nephrogenic diabetes insipidus (HP:0009806)1.71620369
134Narrow forehead (HP:0000341)1.70929170
135Split foot (HP:0001839)1.70821131
136Exotropia (HP:0000577)1.70003820
137Esotropia (HP:0000565)1.69439424
138Open mouth (HP:0000194)1.66463921
139Atrophy/Degeneration involving motor neurons (HP:0007373)1.65988807
140Abnormal ciliary motility (HP:0012262)1.65948646
141Polydipsia (HP:0001959)1.65282755
142Abnormal drinking behavior (HP:0030082)1.65282755
143Aplasia/Hypoplasia of the lens (HP:0008063)1.64684519
144Oligodactyly (HP:0012165)1.62793146
145Hyperglycinemia (HP:0002154)1.60705941
146Preaxial hand polydactyly (HP:0001177)1.60359688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.67382077
2EPHA44.62090886
3MARK14.07880404
4CASK3.30695091
5MAP3K92.84641674
6MAP3K42.77169443
7MAP4K22.73724428
8MAP2K72.63956479
9MINK12.31746625
10TNIK2.16853080
11NTRK22.09996772
12DAPK22.07947509
13MAPK131.95978099
14KSR11.77602010
15MAP3K121.74675612
16PAK61.61870790
17PLK21.61438044
18MAP2K41.58516323
19RIPK41.51628393
20BMPR1B1.50880028
21FES1.47756570
22CDK51.47554521
23PRPF4B1.43903682
24DAPK11.43332359
25CSNK1A1L1.42225452
26KSR21.41226196
27TRIM281.41201447
28CSNK1G11.41016518
29SIK21.39252028
30CAMKK21.38422534
31PNCK1.37182089
32CAMKK11.36438852
33PRKD31.36315863
34NTRK11.35782740
35UHMK11.35631564
36GRK51.32871005
37PRKCG1.21255179
38INSRR1.18079655
39GRK11.13315220
40CAMK2B1.13194214
41CAMK2A1.12706037
42ARAF1.11528771
43CDK191.06373352
44PHKG11.04211051
45PHKG21.04211051
46MAP3K21.02335398
47CSNK1G20.97027246
48STK38L0.96970970
49SGK4940.96637054
50SGK2230.96637054
51ZAK0.94254409
52CDK180.93263936
53MKNK20.93067335
54WNK30.91626333
55ACVR1B0.90905893
56DYRK1A0.90693025
57CDK140.90466823
58ERBB30.89351140
59STK380.88775655
60CDK150.88501220
61AKT30.87903440
62SIK30.86926661
63BMPR20.86407133
64SGK20.86167924
65BCKDK0.77894748
66EPHA30.76731489
67CDK11A0.76706399
68FER0.76429051
69STK390.74797212
70BCR0.73338920
71PAK30.72527134
72CCNB10.72212156
73CAMK10.71358153
74SGK10.71054821
75MARK20.69418756
76PRKCE0.69261477
77CAMK2D0.68564489
78STK110.67632928
79MAPKAPK50.67597076
80BRAF0.65645326
81OXSR10.64040933
82PTK2B0.63880779
83DYRK30.62722018
84TAOK10.62218240
85PRKCH0.60981255
86RET0.58204866
87CDC42BPA0.58134659
88TAOK30.56572020
89NME10.56370746
90FGFR20.56255485
91CSNK1G30.55848290
92PIK3CA0.55641105
93ADRBK10.54466618
94SGK30.54258547
95MAP3K130.53826574
96NUAK10.51079781
97RAF10.50524774
98CAMK2G0.47029697
99CSNK1A10.46468714
100LATS20.46129317
101CAMK1G0.45108053
102DYRK20.45010576
103PINK10.44903441
104PRKCZ0.44869556
105FGR0.44519988
106CSNK1D0.44482716
107MAP3K60.44317960
108PKN10.44198022
109TYRO30.44121053
110RPS6KA30.42826480
111PRKACB0.42358622
112TLK10.41659455
113CAMK40.40409329
114CDK30.40276729
115GRK70.39453482
116WNK10.38956599
117PRKACA0.38877951
118PLK40.38417102
119FYN0.38270681
120PRKCB0.37915507
121MKNK10.37807993
122VRK10.37710081
123RPS6KA20.37644337
124MAPK100.37089724
125EPHB20.37087946
126FRK0.36850673
127MAP3K10.36495885
128ADRBK20.36450272
129SRPK10.36447813
130PRKG10.36231794
131WNK40.35787788
132MUSK0.33710166
133PRKCA0.33125746
134ERBB20.32826006

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.40575699
2Synaptic vesicle cycle_Homo sapiens_hsa047213.29190522
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84741209
4Circadian entrainment_Homo sapiens_hsa047132.76714372
5GABAergic synapse_Homo sapiens_hsa047272.76215428
6Long-term potentiation_Homo sapiens_hsa047202.68699196
7Morphine addiction_Homo sapiens_hsa050322.66302883
8Amphetamine addiction_Homo sapiens_hsa050312.66045398
9Glutamatergic synapse_Homo sapiens_hsa047242.60504425
10Olfactory transduction_Homo sapiens_hsa047402.38786772
11Dopaminergic synapse_Homo sapiens_hsa047282.33482111
12Insulin secretion_Homo sapiens_hsa049112.31452687
13Cocaine addiction_Homo sapiens_hsa050302.13048925
14Taste transduction_Homo sapiens_hsa047422.11552494
15Salivary secretion_Homo sapiens_hsa049701.99146564
16Cholinergic synapse_Homo sapiens_hsa047251.97747145
17Serotonergic synapse_Homo sapiens_hsa047261.90254492
18Collecting duct acid secretion_Homo sapiens_hsa049661.89647820
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89041896
20Long-term depression_Homo sapiens_hsa047301.81588376
21Renin secretion_Homo sapiens_hsa049241.77639926
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75038790
23Calcium signaling pathway_Homo sapiens_hsa040201.62903962
24Oxytocin signaling pathway_Homo sapiens_hsa049211.58563895
25Gastric acid secretion_Homo sapiens_hsa049711.57691518
26Butanoate metabolism_Homo sapiens_hsa006501.51227609
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51172904
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48535827
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42480213
30Protein export_Homo sapiens_hsa030601.40164680
31Gap junction_Homo sapiens_hsa045401.34336332
32Type II diabetes mellitus_Homo sapiens_hsa049301.31653361
33Vibrio cholerae infection_Homo sapiens_hsa051101.30998107
34Axon guidance_Homo sapiens_hsa043601.27141060
35GnRH signaling pathway_Homo sapiens_hsa049121.25796996
36Nitrogen metabolism_Homo sapiens_hsa009101.24026453
37cAMP signaling pathway_Homo sapiens_hsa040241.23214509
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14769179
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14561550
40Estrogen signaling pathway_Homo sapiens_hsa049151.13260717
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10142443
42Cardiac muscle contraction_Homo sapiens_hsa042601.06705459
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04246597
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01716328
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01619655
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00966078
47Linoleic acid metabolism_Homo sapiens_hsa005911.00014065
48Melanogenesis_Homo sapiens_hsa049160.98819560
49Regulation of autophagy_Homo sapiens_hsa041400.96731329
50Ether lipid metabolism_Homo sapiens_hsa005650.96375127
51Phototransduction_Homo sapiens_hsa047440.96009722
52Basal transcription factors_Homo sapiens_hsa030220.91690876
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.88066524
54ErbB signaling pathway_Homo sapiens_hsa040120.86560804
55Glioma_Homo sapiens_hsa052140.86013983
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85165399
57Pancreatic secretion_Homo sapiens_hsa049720.84229777
58Alzheimers disease_Homo sapiens_hsa050100.81307470
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78279926
60RNA polymerase_Homo sapiens_hsa030200.77828907
61Propanoate metabolism_Homo sapiens_hsa006400.77103937
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75807176
63Circadian rhythm_Homo sapiens_hsa047100.75183735
64Oxidative phosphorylation_Homo sapiens_hsa001900.74646582
65Fanconi anemia pathway_Homo sapiens_hsa034600.74583631
66Hedgehog signaling pathway_Homo sapiens_hsa043400.73401804
67Thyroid hormone synthesis_Homo sapiens_hsa049180.72203918
68Oocyte meiosis_Homo sapiens_hsa041140.71685592
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.71496413
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69888240
71Dilated cardiomyopathy_Homo sapiens_hsa054140.69849759
72Steroid biosynthesis_Homo sapiens_hsa001000.69410120
73beta-Alanine metabolism_Homo sapiens_hsa004100.69104085
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69064390
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67467905
76RNA degradation_Homo sapiens_hsa030180.67440345
77Type I diabetes mellitus_Homo sapiens_hsa049400.67335551
78Alcoholism_Homo sapiens_hsa050340.66982345
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66406623
80Tryptophan metabolism_Homo sapiens_hsa003800.65926429
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65690887
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65197851
83Selenocompound metabolism_Homo sapiens_hsa004500.64036245
84Glucagon signaling pathway_Homo sapiens_hsa049220.63952290
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63744334
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.63724175
87Peroxisome_Homo sapiens_hsa041460.63391294
88MAPK signaling pathway_Homo sapiens_hsa040100.59937218
89Hippo signaling pathway_Homo sapiens_hsa043900.59361648
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.58851276
91Choline metabolism in cancer_Homo sapiens_hsa052310.58798141
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57980215
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57684466
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57296516
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57239460
96Parkinsons disease_Homo sapiens_hsa050120.55960649
97ABC transporters_Homo sapiens_hsa020100.55777568
98Dorso-ventral axis formation_Homo sapiens_hsa043200.54446145
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53942208
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53261795
101Basal cell carcinoma_Homo sapiens_hsa052170.51501216
102Inositol phosphate metabolism_Homo sapiens_hsa005620.49470231
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47268006
104Ras signaling pathway_Homo sapiens_hsa040140.46811725
105Glycerolipid metabolism_Homo sapiens_hsa005610.46286740
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46163672
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46136142
108Wnt signaling pathway_Homo sapiens_hsa043100.44643670
109Rap1 signaling pathway_Homo sapiens_hsa040150.42820662
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.42750986
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.42329599
112Retinol metabolism_Homo sapiens_hsa008300.42320883
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42198107
114Endometrial cancer_Homo sapiens_hsa052130.40824062
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40099843
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39136936
117VEGF signaling pathway_Homo sapiens_hsa043700.39014124
118Prion diseases_Homo sapiens_hsa050200.38804064
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37208738
120Ovarian steroidogenesis_Homo sapiens_hsa049130.36273299
121mTOR signaling pathway_Homo sapiens_hsa041500.35461647
122Caffeine metabolism_Homo sapiens_hsa002320.35129444
123Renal cell carcinoma_Homo sapiens_hsa052110.34941169
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.34598507
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34470936
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34354674
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34221330
128Huntingtons disease_Homo sapiens_hsa050160.33633947
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33313791
130Insulin signaling pathway_Homo sapiens_hsa049100.32666372
131Purine metabolism_Homo sapiens_hsa002300.31740513
132Rheumatoid arthritis_Homo sapiens_hsa053230.31614632
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31388976
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30294260
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29632184
136African trypanosomiasis_Homo sapiens_hsa051430.28368097
137Non-small cell lung cancer_Homo sapiens_hsa052230.25499045

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