CDH9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.97333268
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.80773814
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.51999219
4vocalization behavior (GO:0071625)5.17411475
5G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.16468375
6positive regulation of synapse maturation (GO:0090129)5.03686762
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.02411430
8protein localization to synapse (GO:0035418)5.00602113
9synaptic vesicle maturation (GO:0016188)5.00015047
10glutamate secretion (GO:0014047)4.94760238
11glutamate receptor signaling pathway (GO:0007215)4.92237423
12gamma-aminobutyric acid signaling pathway (GO:0007214)4.92125275
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.83397436
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.81954653
15neurotransmitter-gated ion channel clustering (GO:0072578)4.75972490
16regulation of glutamate receptor signaling pathway (GO:1900449)4.71363943
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.68244887
18regulation of synaptic vesicle exocytosis (GO:2000300)4.67935554
19response to pheromone (GO:0019236)4.66874855
20neuron cell-cell adhesion (GO:0007158)4.65958436
21locomotory exploration behavior (GO:0035641)4.50756588
22regulation of synapse structural plasticity (GO:0051823)4.43155409
23cellular potassium ion homeostasis (GO:0030007)4.40000299
24neuron-neuron synaptic transmission (GO:0007270)4.35064545
25synaptic transmission, glutamatergic (GO:0035249)4.32199716
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.20391922
27regulation of synaptic vesicle transport (GO:1902803)4.16596910
28synaptic vesicle docking involved in exocytosis (GO:0016081)4.12213980
29pyrimidine nucleobase catabolic process (GO:0006208)4.08927294
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.04711485
31behavioral fear response (GO:0001662)4.03707194
32behavioral defense response (GO:0002209)4.03707194
33regulation of synaptic transmission, glutamatergic (GO:0051966)4.01938591
34neurotransmitter secretion (GO:0007269)4.01699105
35regulation of neuronal synaptic plasticity (GO:0048168)4.00016233
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.96706328
37regulation of synapse maturation (GO:0090128)3.96590222
38response to histamine (GO:0034776)3.95944363
39exploration behavior (GO:0035640)3.95579042
40synaptic vesicle endocytosis (GO:0048488)3.95326702
41righting reflex (GO:0060013)3.94487582
42gamma-aminobutyric acid transport (GO:0015812)3.94043936
43long-term synaptic potentiation (GO:0060291)3.92027329
44neuronal action potential propagation (GO:0019227)3.90578529
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.87239536
46innervation (GO:0060384)3.81958644
47auditory behavior (GO:0031223)3.80925681
48negative regulation of cytosolic calcium ion concentration (GO:0051481)3.74789003
49positive regulation of membrane potential (GO:0045838)3.73902354
50striatum development (GO:0021756)3.72521793
51membrane depolarization during action potential (GO:0086010)3.71937752
52long-term memory (GO:0007616)3.69507498
53regulation of postsynaptic membrane potential (GO:0060078)3.67749453
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66182801
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.66025644
56negative regulation of mast cell activation (GO:0033004)3.63463570
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.62365245
58behavioral response to nicotine (GO:0035095)3.60635835
59fear response (GO:0042596)3.59302712
60positive regulation of dendritic spine morphogenesis (GO:0061003)3.54465614
61neuronal action potential (GO:0019228)3.54137434
62sodium ion export (GO:0071436)3.54073761
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52730242
64protein localization to cilium (GO:0061512)3.51990079
65regulation of synaptic plasticity (GO:0048167)3.48225940
66neuron recognition (GO:0008038)3.47065310
67mating behavior (GO:0007617)3.43648590
68regulation of dendritic spine morphogenesis (GO:0061001)3.42624366
69nucleobase catabolic process (GO:0046113)3.41906035
70seminiferous tubule development (GO:0072520)3.41779235
71regulation of neurotransmitter secretion (GO:0046928)3.41008431
72membrane hyperpolarization (GO:0060081)3.40413043
73neurotransmitter transport (GO:0006836)3.39140641
74cerebellar Purkinje cell differentiation (GO:0021702)3.36058656
75regulation of vesicle fusion (GO:0031338)3.34649562
76membrane depolarization (GO:0051899)3.34604568
77presynaptic membrane assembly (GO:0097105)3.34399070
78regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.31852886
79regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.31852886
80cellular sodium ion homeostasis (GO:0006883)3.31195659
81prepulse inhibition (GO:0060134)3.30099442
82synaptic transmission (GO:0007268)3.29084657
83layer formation in cerebral cortex (GO:0021819)3.27742331
84DNA deamination (GO:0045006)3.27503736
85dendritic spine morphogenesis (GO:0060997)3.27236653
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.26808238
87regulation of neurotransmitter transport (GO:0051588)3.26376151
88fucose catabolic process (GO:0019317)3.24053987
89L-fucose metabolic process (GO:0042354)3.24053987
90L-fucose catabolic process (GO:0042355)3.24053987
91cell communication by electrical coupling (GO:0010644)3.23311986
92detection of light stimulus involved in sensory perception (GO:0050962)3.21791038
93detection of light stimulus involved in visual perception (GO:0050908)3.21791038
94transmission of nerve impulse (GO:0019226)3.19617155
95aggressive behavior (GO:0002118)3.16772554
96learning (GO:0007612)3.15331981
97synapse assembly (GO:0007416)3.14428656
98potassium ion homeostasis (GO:0055075)3.13419166
99long term synaptic depression (GO:0060292)3.13230040
100postsynaptic membrane organization (GO:0001941)3.11842460
101startle response (GO:0001964)3.09907220
102iron-sulfur cluster assembly (GO:0016226)3.06303904
103metallo-sulfur cluster assembly (GO:0031163)3.06303904
104regulation of synaptic transmission (GO:0050804)3.06301320
105positive regulation of synaptic transmission (GO:0050806)3.05582497
106indolalkylamine metabolic process (GO:0006586)3.05141257
107establishment of synaptic vesicle localization (GO:0097480)3.04763818
108synaptic vesicle transport (GO:0048489)3.04763818
109synaptic transmission, dopaminergic (GO:0001963)3.04485122
110drinking behavior (GO:0042756)3.03954625
111positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03657809
112behavioral response to cocaine (GO:0048148)3.03482967
113proline transport (GO:0015824)3.01985954
114regulation of neurotransmitter levels (GO:0001505)3.01635126
115positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.01521822
116protein polyglutamylation (GO:0018095)3.01212971
117presynaptic membrane organization (GO:0097090)3.00667175
118axonal fasciculation (GO:0007413)2.99962842
119positive regulation of dendritic spine development (GO:0060999)2.98082333
120calcium ion import (GO:0070509)2.95196625
121dendrite morphogenesis (GO:0048813)2.93641863
122positive regulation of protein homodimerization activity (GO:0090073)2.93369549
123mechanosensory behavior (GO:0007638)2.91567122
124negative regulation of telomere maintenance (GO:0032205)2.91240375
125tryptophan catabolic process (GO:0006569)2.88932803
126indole-containing compound catabolic process (GO:0042436)2.88932803
127indolalkylamine catabolic process (GO:0046218)2.88932803
128regulation of feeding behavior (GO:0060259)2.88371801
129positive regulation of amino acid transport (GO:0051957)2.84202247
130behavioral response to ethanol (GO:0048149)2.83965424
131regulation of action potential (GO:0098900)2.83322771
132reflex (GO:0060004)2.80731432
133retinal cone cell development (GO:0046549)2.79896046
134indole-containing compound metabolic process (GO:0042430)2.79444956
135C4-dicarboxylate transport (GO:0015740)2.78933355
136piRNA metabolic process (GO:0034587)2.78665894
137tryptophan metabolic process (GO:0006568)2.78533605
138epithelial cell differentiation involved in kidney development (GO:0035850)2.74242892
139detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73694274
140cellular ketone body metabolic process (GO:0046950)2.71478883
141GPI anchor metabolic process (GO:0006505)2.70672034
142establishment of mitochondrion localization (GO:0051654)2.69460061
143regulation of glutamate secretion (GO:0014048)2.66334577
144serotonin metabolic process (GO:0042428)2.63949287
145positive regulation of mitochondrial fission (GO:0090141)2.63525968
146base-excision repair, AP site formation (GO:0006285)2.60837667
147positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.59657503
148response to auditory stimulus (GO:0010996)2.59539246
149negative regulation of cation channel activity (GO:2001258)2.57746606
150action potential (GO:0001508)2.57562412
151negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.55515217
152pyrimidine dimer repair (GO:0006290)2.54714881
153regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.54586267
154glycosphingolipid biosynthetic process (GO:0006688)2.54033053
155primary amino compound metabolic process (GO:1901160)2.53246196
156neural tube formation (GO:0001841)2.48787595
157photoreceptor cell maintenance (GO:0045494)2.48700232
158regulation of female receptivity (GO:0045924)2.48579241
159serotonin receptor signaling pathway (GO:0007210)2.48082331
160establishment of protein localization to Golgi (GO:0072600)2.47388280
161glycolipid biosynthetic process (GO:0009247)2.45062118
162short-chain fatty acid metabolic process (GO:0046459)2.44678001

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.70126933
2GBX2_23144817_ChIP-Seq_PC3_Human4.24600535
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08428334
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02387543
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98863004
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.86601064
7REST_21632747_ChIP-Seq_MESCs_Mouse2.66722918
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64164469
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58289177
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54442027
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54442027
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.52397584
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51083635
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.49108636
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42438810
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40293825
17DROSHA_22980978_ChIP-Seq_HELA_Human2.39045110
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.32773923
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.25046269
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.24593400
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.23816371
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22799740
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20955978
24TAF15_26573619_Chip-Seq_HEK293_Human2.18616976
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18546640
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.16474882
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15463214
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14904271
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13932487
30REST_18959480_ChIP-ChIP_MESCs_Mouse2.12492083
31IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11003111
32AR_21572438_ChIP-Seq_LNCaP_Human2.07584125
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05063727
34FLI1_27457419_Chip-Seq_LIVER_Mouse2.01921806
35* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01658172
36* EWS_26573619_Chip-Seq_HEK293_Human2.00346370
37* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96054154
38* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94893163
39SMAD4_21799915_ChIP-Seq_A2780_Human1.85507116
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81286394
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79461235
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78134083
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72757564
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71073793
45* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68149219
46* P300_19829295_ChIP-Seq_ESCs_Human1.63748904
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56649066
48FUS_26573619_Chip-Seq_HEK293_Human1.56505379
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54459561
50TP53_22573176_ChIP-Seq_HFKS_Human1.53907184
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.51490432
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49576723
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.46207429
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.43369909
55* AR_25329375_ChIP-Seq_VCAP_Human1.43335574
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.42851890
57IRF1_19129219_ChIP-ChIP_H3396_Human1.42682913
58IGF1R_20145208_ChIP-Seq_DFB_Human1.42278845
59MYC_18940864_ChIP-ChIP_HL60_Human1.41020235
60* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40433601
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40199408
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38981617
63SOX2_19829295_ChIP-Seq_ESCs_Human1.38917945
64NANOG_19829295_ChIP-Seq_ESCs_Human1.38917945
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38147879
66FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.37576103
67STAT3_23295773_ChIP-Seq_U87_Human1.35939195
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35291571
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33647033
70* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33179329
71* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32425769
72* RNF2_27304074_Chip-Seq_NSC_Mouse1.31387286
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31160269
74VDR_22108803_ChIP-Seq_LS180_Human1.30251846
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27818012
76* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25428686
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25356780
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24746759
79* TAL1_26923725_Chip-Seq_HPCs_Mouse1.24059658
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23234508
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22765776
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22281120
83* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22061699
84AR_19668381_ChIP-Seq_PC3_Human1.21867790
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21729096
86ZNF274_21170338_ChIP-Seq_K562_Hela1.21144273
87* TCF4_23295773_ChIP-Seq_U87_Human1.20652124
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.18998211
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.15435879
90* TCF4_22108803_ChIP-Seq_LS180_Human1.12427466
91* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12217312
92* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11841868
93NCOR_22424771_ChIP-Seq_293T_Human1.11277601
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09781132
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09781132
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09586054
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09538607
98SALL1_21062744_ChIP-ChIP_HESCs_Human1.09500686
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.08853246
100* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08369212
101AHR_22903824_ChIP-Seq_MCF-7_Human1.08287788
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07094771
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06953188
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05957202
105CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05624935
106EST1_17652178_ChIP-ChIP_JURKAT_Human1.05025713
107RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04282961
108ERG_21242973_ChIP-ChIP_JURKAT_Human1.03937900
109ER_23166858_ChIP-Seq_MCF-7_Human1.03501426
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03267050
111NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03200763
112FOXA1_25329375_ChIP-Seq_VCAP_Human1.03128581
113FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03128581
114* RUNX2_22187159_ChIP-Seq_PCA_Human1.02758391
115* JUN_21703547_ChIP-Seq_K562_Human1.02218918
116ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02007290
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01632845
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01372255
119P53_22387025_ChIP-Seq_ESCs_Mouse1.01132700
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00802451
121WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00530248
122AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99880407
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99623238
124BCAT_22108803_ChIP-Seq_LS180_Human0.99502304
125VDR_23849224_ChIP-Seq_CD4+_Human0.99239136
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98976274
127FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98441539
128EZH2_27294783_Chip-Seq_NPCs_Mouse0.98265076
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98170141
130POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97900215
131RING1B_27294783_Chip-Seq_NPCs_Mouse0.97731188
132CBP_20019798_ChIP-Seq_JUKART_Human0.97138433
133IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97138433
134NANOG_18555785_Chip-Seq_ESCs_Mouse0.95874065
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.93499295
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92450246
137SOX9_26525672_Chip-Seq_HEART_Mouse0.91560247
138FLI1_21867929_ChIP-Seq_TH2_Mouse0.91255023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.34364336
2MP0003880_abnormal_central_pattern4.73602411
3MP0003635_abnormal_synaptic_transmissio4.07745241
4MP0002822_catalepsy3.63897427
5MP0009745_abnormal_behavioral_response3.46162641
6MP0002063_abnormal_learning/memory/cond3.32364070
7MP0002064_seizures3.22073663
8MP0004270_analgesia3.11141258
9MP0009046_muscle_twitch2.99180336
10MP0002572_abnormal_emotion/affect_behav2.84928581
11MP0001968_abnormal_touch/_nociception2.79901050
12MP0002272_abnormal_nervous_system2.65423538
13MP0001984_abnormal_olfaction2.63588197
14MP0002734_abnormal_mechanical_nocicepti2.54663543
15MP0001486_abnormal_startle_reflex2.51160206
16MP0001501_abnormal_sleep_pattern2.48895689
17MP0002735_abnormal_chemical_nociception2.26565540
18MP0005551_abnormal_eye_electrophysiolog2.22452616
19MP0002736_abnormal_nociception_after2.21777333
20MP0005084_abnormal_gallbladder_morpholo2.12485316
21MP0003787_abnormal_imprinting2.09898967
22MP0002067_abnormal_sensory_capabilities2.06264389
23MP0001986_abnormal_taste_sensitivity1.97001188
24MP0005670_abnormal_white_adipose1.95425696
25MP0002184_abnormal_innervation1.94694689
26MP0001502_abnormal_circadian_rhythm1.94143676
27MP0003879_abnormal_hair_cell1.93600524
28MP0000569_abnormal_digit_pigmentation1.93570832
29MP0001440_abnormal_grooming_behavior1.93117457
30MP0005423_abnormal_somatic_nervous1.93059927
31MP0004147_increased_porphyrin_level1.88377723
32MP0005646_abnormal_pituitary_gland1.86962202
33MP0001970_abnormal_pain_threshold1.80652550
34MP0001529_abnormal_vocalization1.76929222
35MP0004043_abnormal_pH_regulation1.70826681
36MP0001188_hyperpigmentation1.68460142
37MP0008569_lethality_at_weaning1.68429409
38MP0002733_abnormal_thermal_nociception1.65901027
39MP0002557_abnormal_social/conspecific_i1.61851804
40MP0002090_abnormal_vision1.61785956
41MP0002138_abnormal_hepatobiliary_system1.60055159
42MP0000778_abnormal_nervous_system1.56431778
43MP0004811_abnormal_neuron_physiology1.56247274
44MP0005386_behavior/neurological_phenoty1.55551460
45MP0004924_abnormal_behavior1.55551460
46MP0006276_abnormal_autonomic_nervous1.52162870
47MP0003329_amyloid_beta_deposits1.51345698
48MP0002909_abnormal_adrenal_gland1.49432391
49MP0001905_abnormal_dopamine_level1.45925447
50MP0002882_abnormal_neuron_morphology1.44530126
51MP0000955_abnormal_spinal_cord1.41478627
52MP0004142_abnormal_muscle_tone1.33879079
53MP0002066_abnormal_motor_capabilities/c1.31590818
54MP0010386_abnormal_urinary_bladder1.27369540
55MP0008058_abnormal_DNA_repair1.26330330
56MP0004233_abnormal_muscle_weight1.26292218
57MP0004858_abnormal_nervous_system1.21776516
58MP0009780_abnormal_chondrocyte_physiolo1.20275034
59MP0005410_abnormal_fertilization1.18246845
60MP0006072_abnormal_retinal_apoptosis1.17091001
61MP0003718_maternal_effect1.11808410
62MP0006292_abnormal_olfactory_placode1.11259852
63MP0003633_abnormal_nervous_system1.10405287
64MP0005645_abnormal_hypothalamus_physiol1.10317079
65MP0004215_abnormal_myocardial_fiber1.10215967
66MP0002229_neurodegeneration1.09735562
67MP0002102_abnormal_ear_morphology1.08183178
68MP0003122_maternal_imprinting1.08164316
69MP0000751_myopathy1.06465457
70MP0001346_abnormal_lacrimal_gland1.04907347
71MP0002876_abnormal_thyroid_physiology1.04558143
72MP0008877_abnormal_DNA_methylation1.02871058
73MP0002152_abnormal_brain_morphology1.01710273
74MP0005394_taste/olfaction_phenotype0.99997161
75MP0005499_abnormal_olfactory_system0.99997161
76MP0002752_abnormal_somatic_nervous0.99786743
77MP0004885_abnormal_endolymph0.99406770
78MP0004085_abnormal_heartbeat0.98319690
79MP0002069_abnormal_eating/drinking_beha0.96471579
80MP0003631_nervous_system_phenotype0.96128648
81MP0008875_abnormal_xenobiotic_pharmacok0.96087774
82MP0004145_abnormal_muscle_electrophysio0.95499116
83MP0002160_abnormal_reproductive_system0.89798741
84MP0000631_abnormal_neuroendocrine_gland0.89551260
85MP0008872_abnormal_physiological_respon0.88897792
86MP0003136_yellow_coat_color0.86464091
87MP0003195_calcinosis0.86455895
88MP0002638_abnormal_pupillary_reflex0.86100415
89MP0001963_abnormal_hearing_physiology0.84369251
90MP0008874_decreased_physiological_sensi0.83598872
91MP0003698_abnormal_male_reproductive0.83268483
92MP0002928_abnormal_bile_duct0.80171468
93MP0001764_abnormal_homeostasis0.79615655
94MP0004742_abnormal_vestibular_system0.76602972
95MP0000372_irregular_coat_pigmentation0.75925541
96MP0005535_abnormal_body_temperature0.75661390
97MP0001177_atelectasis0.75658909
98MP0000427_abnormal_hair_cycle0.75596414
99MP0008995_early_reproductive_senescence0.75306000
100MP0005195_abnormal_posterior_eye0.74393315
101MP0002837_dystrophic_cardiac_calcinosis0.73893406
102MP0008004_abnormal_stomach_pH0.73054103
103MP0005389_reproductive_system_phenotype0.72912464
104MP0006035_abnormal_mitochondrial_morpho0.70432916
105MP0000230_abnormal_systemic_arterial0.69939138
106MP0005253_abnormal_eye_physiology0.69346218
107MP0003075_altered_response_to0.68093897
108MP0003786_premature_aging0.68009533
109MP0003634_abnormal_glial_cell0.67280948
110MP0005187_abnormal_penis_morphology0.67030380
111MP0003632_abnormal_nervous_system0.64683549
112MP0004036_abnormal_muscle_relaxation0.64249637
113MP0001929_abnormal_gametogenesis0.63748922
114MP0000013_abnormal_adipose_tissue0.63389445
115MP0001664_abnormal_digestion0.63008892
116MP0000604_amyloidosis0.62704938
117MP0002234_abnormal_pharynx_morphology0.61568416
118MP0005595_abnormal_vascular_smooth0.61065827
119MP0001293_anophthalmia0.60259056
120MP0002332_abnormal_exercise_endurance0.60081559
121MP0005409_darkened_coat_color0.58556613
122MP0003137_abnormal_impulse_conducting0.58545829
123MP0005171_absent_coat_pigmentation0.58056011
124MP0002751_abnormal_autonomic_nervous0.57791734
125MP0008961_abnormal_basal_metabolism0.56149617
126MP0005248_abnormal_Harderian_gland0.53853791
127MP0001485_abnormal_pinna_reflex0.51440788
128MP0005620_abnormal_muscle_contractility0.51168475
129MP0003121_genomic_imprinting0.50573719

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.85692421
2Myokymia (HP:0002411)6.15074355
3Epileptic encephalopathy (HP:0200134)5.87335379
4Febrile seizures (HP:0002373)5.69358769
5Focal seizures (HP:0007359)5.40186633
6Congenital stationary night blindness (HP:0007642)4.80271615
7Progressive cerebellar ataxia (HP:0002073)4.73869015
8Absence seizures (HP:0002121)4.70041287
9Atonic seizures (HP:0010819)4.62765329
10Visual hallucinations (HP:0002367)4.50520520
11Dialeptic seizures (HP:0011146)4.41393876
12Generalized tonic-clonic seizures (HP:0002069)4.03623181
13Pancreatic cysts (HP:0001737)4.02272514
14Pancreatic fibrosis (HP:0100732)3.60513054
15Gaze-evoked nystagmus (HP:0000640)3.57949329
16Hyperventilation (HP:0002883)3.49264314
17Dysdiadochokinesis (HP:0002075)3.49062415
18Chronic hepatic failure (HP:0100626)3.34010825
19Impaired vibration sensation in the lower limbs (HP:0002166)3.33094455
20Action tremor (HP:0002345)3.20450875
21Nephronophthisis (HP:0000090)3.19308821
22Bile duct proliferation (HP:0001408)3.17411392
23Abnormal biliary tract physiology (HP:0012439)3.17411392
24Scanning speech (HP:0002168)3.15838196
25Dysmetria (HP:0001310)3.12714844
26Central scotoma (HP:0000603)3.12210547
27True hermaphroditism (HP:0010459)3.10876367
28Epileptiform EEG discharges (HP:0011182)3.10474964
29Hyperglycinemia (HP:0002154)3.10081477
30Type II lissencephaly (HP:0007260)3.04180850
31Truncal ataxia (HP:0002078)3.01048379
32EEG with generalized epileptiform discharges (HP:0011198)2.89223201
33Depression (HP:0000716)2.87895123
34Broad-based gait (HP:0002136)2.87718192
35Amblyopia (HP:0000646)2.86346765
36Severe visual impairment (HP:0001141)2.77171658
37Abolished electroretinogram (ERG) (HP:0000550)2.75913758
38Abnormality of macular pigmentation (HP:0008002)2.73895127
39Mutism (HP:0002300)2.70740745
40Abnormal eating behavior (HP:0100738)2.70670745
41Drooling (HP:0002307)2.69603747
42Excessive salivation (HP:0003781)2.69603747
43Gait imbalance (HP:0002141)2.67017888
44Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.65956391
45Degeneration of the lateral corticospinal tracts (HP:0002314)2.65956391
46Genetic anticipation (HP:0003743)2.63650595
47Abnormality of the renal medulla (HP:0100957)2.60559593
48Abnormality of the lower motor neuron (HP:0002366)2.60540506
49Anxiety (HP:0000739)2.60271134
50Hemiparesis (HP:0001269)2.59999562
51Delayed CNS myelination (HP:0002188)2.54068790
52Impaired smooth pursuit (HP:0007772)2.51058397
53Molar tooth sign on MRI (HP:0002419)2.49909703
54Abnormality of midbrain morphology (HP:0002418)2.49909703
55Hypsarrhythmia (HP:0002521)2.48299552
56Supranuclear gaze palsy (HP:0000605)2.46411427
57Torticollis (HP:0000473)2.46069104
58Dysmetric saccades (HP:0000641)2.44740518
59Poor eye contact (HP:0000817)2.41982728
60Absent speech (HP:0001344)2.41181225
61Postural instability (HP:0002172)2.39819787
62Congenital primary aphakia (HP:0007707)2.38979650
63Hypothermia (HP:0002045)2.38674263
64Urinary bladder sphincter dysfunction (HP:0002839)2.38297701
65Decreased circulating renin level (HP:0003351)2.37543358
66Fetal akinesia sequence (HP:0001989)2.36355315
67Abnormality of ocular smooth pursuit (HP:0000617)2.35877860
68Abnormality of the corticospinal tract (HP:0002492)2.33123150
69Tubulointerstitial nephritis (HP:0001970)2.33065680
70Cholecystitis (HP:0001082)2.32668915
71Abnormal gallbladder physiology (HP:0012438)2.32668915
72Impaired social interactions (HP:0000735)2.31560901
73Abnormal social behavior (HP:0012433)2.31560901
74Absent/shortened dynein arms (HP:0200106)2.30993718
75Dynein arm defect of respiratory motile cilia (HP:0012255)2.30993718
76Ankle clonus (HP:0011448)2.30713073
77Cystic liver disease (HP:0006706)2.30351749
78Diplopia (HP:0000651)2.26180935
79Abnormality of binocular vision (HP:0011514)2.26180935
80Focal dystonia (HP:0004373)2.25486155
81Nephrogenic diabetes insipidus (HP:0009806)2.24822337
82Impaired vibratory sensation (HP:0002495)2.23838169
83Medial flaring of the eyebrow (HP:0010747)2.23411374
84Protruding tongue (HP:0010808)2.19491679
85Attenuation of retinal blood vessels (HP:0007843)2.17204429
86Metaphyseal dysplasia (HP:0100255)2.14573286
87Incomplete penetrance (HP:0003829)2.13679219
88Progressive inability to walk (HP:0002505)2.13192046
89Polyphagia (HP:0002591)2.12674381
90Septo-optic dysplasia (HP:0100842)2.12295541
91Aplasia/Hypoplasia of the tongue (HP:0010295)2.12075521
92Lissencephaly (HP:0001339)2.11241513
93Failure to thrive in infancy (HP:0001531)2.10425397
94Spastic gait (HP:0002064)2.10056329
95Bradykinesia (HP:0002067)2.08399160
96Abnormality of the labia minora (HP:0012880)2.06098196
97Methylmalonic acidemia (HP:0002912)2.03511777
98Abnormality of the renal cortex (HP:0011035)2.02225589
99Aplasia/Hypoplasia of the tibia (HP:0005772)2.00854641
100Gait ataxia (HP:0002066)1.99598266
101Stereotypic behavior (HP:0000733)1.99444185
102Craniofacial dystonia (HP:0012179)1.98324658
103Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98296127
104Hemiplegia (HP:0002301)1.97742169
105Ventricular fibrillation (HP:0001663)1.97314461
106Generalized myoclonic seizures (HP:0002123)1.96955217
107Inability to walk (HP:0002540)1.96466562
108Colon cancer (HP:0003003)1.96410331
109Optic nerve hypoplasia (HP:0000609)1.96068359
110Thyroid-stimulating hormone excess (HP:0002925)1.94991049
111Specific learning disability (HP:0001328)1.94932588
112Mitochondrial inheritance (HP:0001427)1.94276892
113Morphological abnormality of the pyramidal tract (HP:0002062)1.94005170
114Status epilepticus (HP:0002133)1.93971575
115Urinary urgency (HP:0000012)1.92992887
116Poor coordination (HP:0002370)1.91524317
117Abnormality of serine family amino acid metabolism (HP:0010894)1.90956173
118Abnormality of glycine metabolism (HP:0010895)1.90956173
119Abnormal hair whorl (HP:0010721)1.89953647
120Stomach cancer (HP:0012126)1.89623989
121Pheochromocytoma (HP:0002666)1.88563908
122Increased circulating renin level (HP:0000848)1.88455729
123Abnormal EKG (HP:0003115)1.88132351
124Limb ataxia (HP:0002070)1.86587267
125Thickened helices (HP:0000391)1.86364376
126Genital tract atresia (HP:0001827)1.85529411
127Congenital hepatic fibrosis (HP:0002612)1.85428774
128Neuronal loss in central nervous system (HP:0002529)1.83540895
129Prolonged QT interval (HP:0001657)1.82754021
130Retinal dysplasia (HP:0007973)1.82516960
131Hypoplasia of the brainstem (HP:0002365)1.82259361
132Aplasia/Hypoplasia of the brainstem (HP:0007362)1.82259361
133Hepatocellular necrosis (HP:0001404)1.82232203
134Blue irides (HP:0000635)1.82087429
135Supernumerary spleens (HP:0009799)1.81705059
136Vaginal atresia (HP:0000148)1.80809538
137Decreased central vision (HP:0007663)1.80538692
138Pendular nystagmus (HP:0012043)1.78994581
139Abnormality of salivation (HP:0100755)1.78718949
140Postaxial foot polydactyly (HP:0001830)1.78491146
141Abnormal respiratory motile cilium morphology (HP:0005938)1.77937573
142Abnormal respiratory epithelium morphology (HP:0012253)1.77937573
143Abnormality of saccadic eye movements (HP:0000570)1.77827566
144Poor suck (HP:0002033)1.77345373
145Limb dystonia (HP:0002451)1.76905466
146Agitation (HP:0000713)1.76796067
147Acute lymphatic leukemia (HP:0006721)1.76547117
148CNS hypomyelination (HP:0003429)1.75015296
149Widely spaced teeth (HP:0000687)1.74904806
150Hypoventilation (HP:0002791)1.74580031
151Scotoma (HP:0000575)1.72943987
152Clumsiness (HP:0002312)1.72830509
153Intention tremor (HP:0002080)1.72151531
154Symphalangism affecting the phalanges of the hand (HP:0009773)1.71853543
155Abnormal rod and cone electroretinograms (HP:0008323)1.71669081
156Tubulointerstitial abnormality (HP:0001969)1.71614607
157Cerebellar dysplasia (HP:0007033)1.71148643
158Abnormality of alanine metabolism (HP:0010916)1.70418808
159Hyperalaninemia (HP:0003348)1.70418808
160Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70418808
161Hepatic necrosis (HP:0002605)1.70081152
162Termporal pattern (HP:0011008)1.69473011
163Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69265519
164Renal cortical cysts (HP:0000803)1.68236841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.65643906
2EPHA44.66476272
3MAP3K93.42511027
4MAP3K43.10123871
5FRK3.08413441
6MAP2K72.75357775
7MAP4K22.68075695
8PRPF4B2.56411190
9MINK12.46660024
10PAK62.34223676
11TNIK2.34081724
12KSR22.23382393
13MARK12.15025875
14KSR12.08053337
15TAOK32.00733374
16ADRBK21.99207303
17NME11.98410189
18ARAF1.97678085
19MAP3K131.90812817
20GRK11.87793809
21DAPK21.81265055
22CASK1.77666792
23EIF2AK31.68048776
24NTRK21.66579267
25MAP2K41.60518558
26CSNK1G31.57576884
27FES1.54253361
28ZAK1.52216514
29CSNK1A1L1.48262030
30DAPK11.45116242
31PLK21.40818130
32TRIM281.39853392
33MAPKAPK31.38364451
34MAPK131.37564647
35CDK51.34931272
36PRKD31.31882233
37DYRK21.28752689
38CDK191.27308801
39CSNK1G11.26470407
40STK381.22502685
41TXK1.22426924
42GRK51.21958438
43TESK21.21134004
44PRKCG1.20879004
45MAP3K121.17432400
46BCKDK1.17350413
47RIPK41.16715581
48NUAK11.16077596
49CAMK2A1.16071913
50AKT31.15601594
51CAMKK11.15223722
52BMPR1B1.14630827
53CAMK2B1.13646916
54ERBB31.08069804
55SGK2231.07936046
56SGK4941.07936046
57DYRK1A1.06061613
58SGK21.02592805
59RAF11.02579044
60FLT31.00946509
61CAMK11.00517849
62BRAF1.00119734
63PHKG10.99624053
64PHKG20.99624053
65CAMKK20.99622464
66TAOK20.93881275
67PTK2B0.90621033
68CDK180.90583141
69CDK140.89530082
70NTRK10.89475215
71TLK10.89177005
72TEC0.89041768
73CAMK2D0.88982896
74MAP3K20.88503547
75PAK30.87792177
76CDK150.85626151
77MUSK0.85117984
78SIK30.82484470
79OXSR10.79589037
80NEK10.78165383
81MAP3K70.77212015
82PNCK0.75931141
83MAP3K60.75599597
84PINK10.74759825
85CDK11A0.72816411
86BMPR20.72799890
87FER0.72493301
88SGK10.71930263
89SIK20.71582743
90RPS6KA40.71284869
91PRKCE0.69893661
92RPS6KA50.69632598
93WNK30.68690536
94VRK10.68463130
95CDK30.66720976
96SGK30.65334651
97PIK3CA0.65060588
98SRPK10.63808546
99STK110.63739585
100TIE10.62933008
101UHMK10.62556542
102TNK20.61445058
103KDR0.60692316
104LATS20.59243145
105MAP2K10.59107862
106MAP3K10.58157092
107KIT0.57478382
108CSNK1A10.57461863
109CAMK2G0.57264635
110MARK20.57128220
111ADRBK10.54408621
112PRKCH0.53703029
113ITK0.53186477
114IRAK20.53027669
115PLK40.53020067
116PKN10.52894634
117CDK80.52120022
118SYK0.49330203
119MAP2K60.49055504
120CSNK1G20.47514751
121RPS6KA30.46811115
122MAP3K50.46616039
123STK160.46149336
124PDK10.45666298
125PRKCQ0.45138290
126CDC70.45006814
127ACVR1B0.43389397
128PRKCB0.43039895
129RET0.42854159
130PRKCZ0.41693079
131CAMK1G0.41618444
132CSNK1D0.41499209
133LMTK20.41071845
134MKNK10.40748001
135CAMK40.40617172
136TAOK10.40301134
137NEK60.39575053
138PRKACA0.38966445
139PRKCA0.38847842
140PDPK10.38694942
141MOS0.38657907
142PRKG10.38491814
143CDC42BPA0.38177458
144DYRK30.38113032
145CSNK1E0.37834531
146MKNK20.37483387
147CCNB10.36680525
148BCR0.35822022
149INSRR0.35061527
150MAPKAPK50.34897620
151TYRO30.34586318
152PRKACB0.34421552
153FGR0.34288610

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.62635677
2Synaptic vesicle cycle_Homo sapiens_hsa047213.68477864
3GABAergic synapse_Homo sapiens_hsa047273.23941582
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.20939993
5Morphine addiction_Homo sapiens_hsa050322.98270556
6Circadian entrainment_Homo sapiens_hsa047132.92098990
7Olfactory transduction_Homo sapiens_hsa047402.71609507
8Glutamatergic synapse_Homo sapiens_hsa047242.58800192
9Butanoate metabolism_Homo sapiens_hsa006502.47824204
10Long-term potentiation_Homo sapiens_hsa047202.38775050
11Amphetamine addiction_Homo sapiens_hsa050312.35048204
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26910603
13Dopaminergic synapse_Homo sapiens_hsa047282.14436792
14Collecting duct acid secretion_Homo sapiens_hsa049662.10681529
15Insulin secretion_Homo sapiens_hsa049112.08140739
16Salivary secretion_Homo sapiens_hsa049702.05847643
17Cholinergic synapse_Homo sapiens_hsa047251.99122526
18Serotonergic synapse_Homo sapiens_hsa047261.92887371
19Taste transduction_Homo sapiens_hsa047421.92842509
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85767636
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85001858
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76688958
23Linoleic acid metabolism_Homo sapiens_hsa005911.75901800
24Renin secretion_Homo sapiens_hsa049241.74954351
25Cocaine addiction_Homo sapiens_hsa050301.73499085
26Calcium signaling pathway_Homo sapiens_hsa040201.70386014
27Oxytocin signaling pathway_Homo sapiens_hsa049211.69620986
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64937807
29Long-term depression_Homo sapiens_hsa047301.59341055
30Peroxisome_Homo sapiens_hsa041461.50708449
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48859857
32Gastric acid secretion_Homo sapiens_hsa049711.45552970
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43776929
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41455733
35Nitrogen metabolism_Homo sapiens_hsa009101.37285620
36RNA degradation_Homo sapiens_hsa030181.33219415
37Ether lipid metabolism_Homo sapiens_hsa005651.33208165
38Basal transcription factors_Homo sapiens_hsa030221.30089995
39GnRH signaling pathway_Homo sapiens_hsa049121.29578796
40cAMP signaling pathway_Homo sapiens_hsa040241.29020173
41Propanoate metabolism_Homo sapiens_hsa006401.27459789
42Fanconi anemia pathway_Homo sapiens_hsa034601.24422759
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24358332
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23520194
45Cardiac muscle contraction_Homo sapiens_hsa042601.22168176
46Circadian rhythm_Homo sapiens_hsa047101.21309121
47Vibrio cholerae infection_Homo sapiens_hsa051101.20841069
48Regulation of autophagy_Homo sapiens_hsa041401.19659527
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17530241
50Gap junction_Homo sapiens_hsa045401.15431893
51Homologous recombination_Homo sapiens_hsa034401.14627490
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14385542
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12097616
54Type II diabetes mellitus_Homo sapiens_hsa049301.09182121
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08763624
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08649196
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06168764
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.00040831
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98319804
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.94838560
61Tryptophan metabolism_Homo sapiens_hsa003800.93532202
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92603035
63Axon guidance_Homo sapiens_hsa043600.90338799
64Estrogen signaling pathway_Homo sapiens_hsa049150.89003654
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85218740
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85186954
67ErbB signaling pathway_Homo sapiens_hsa040120.85179938
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84964104
69Glioma_Homo sapiens_hsa052140.82185553
70Dilated cardiomyopathy_Homo sapiens_hsa054140.80810846
71Phototransduction_Homo sapiens_hsa047440.80754047
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.80733589
73Huntingtons disease_Homo sapiens_hsa050160.80366863
74Arachidonic acid metabolism_Homo sapiens_hsa005900.77903015
75RNA polymerase_Homo sapiens_hsa030200.74111023
76Protein export_Homo sapiens_hsa030600.73992207
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.73142125
78Chemical carcinogenesis_Homo sapiens_hsa052040.71541633
79Pancreatic secretion_Homo sapiens_hsa049720.71057337
80Melanogenesis_Homo sapiens_hsa049160.68155679
81Fatty acid biosynthesis_Homo sapiens_hsa000610.67821946
82Oocyte meiosis_Homo sapiens_hsa041140.64639334
83Choline metabolism in cancer_Homo sapiens_hsa052310.64598517
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64589938
85MAPK signaling pathway_Homo sapiens_hsa040100.64536074
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63216564
87RNA transport_Homo sapiens_hsa030130.61691960
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60812478
89Purine metabolism_Homo sapiens_hsa002300.60578617
90Retinol metabolism_Homo sapiens_hsa008300.59714503
91Alcoholism_Homo sapiens_hsa050340.56843901
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56204963
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55883374
94Thyroid hormone synthesis_Homo sapiens_hsa049180.55404049
95Dorso-ventral axis formation_Homo sapiens_hsa043200.54721728
96Ras signaling pathway_Homo sapiens_hsa040140.53984385
97Oxidative phosphorylation_Homo sapiens_hsa001900.51792858
98Type I diabetes mellitus_Homo sapiens_hsa049400.51275996
99Glucagon signaling pathway_Homo sapiens_hsa049220.51200445
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51195531
101Selenocompound metabolism_Homo sapiens_hsa004500.50999743
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50806312
103Metabolic pathways_Homo sapiens_hsa011000.50786658
104Rheumatoid arthritis_Homo sapiens_hsa053230.50596351
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50433254
106Alzheimers disease_Homo sapiens_hsa050100.50424565
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49222520
108Inositol phosphate metabolism_Homo sapiens_hsa005620.48494583
109Proteasome_Homo sapiens_hsa030500.48012146
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46646587
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46523136
112ABC transporters_Homo sapiens_hsa020100.45640642
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45161958
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44332785
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40675177
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.39994547
117Base excision repair_Homo sapiens_hsa034100.39455490
118Rap1 signaling pathway_Homo sapiens_hsa040150.38710450
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38645930
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37844599
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36774304
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36570337
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36440096
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.35307148
125VEGF signaling pathway_Homo sapiens_hsa043700.34378745
126Fatty acid metabolism_Homo sapiens_hsa012120.34262920
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33699949
128mTOR signaling pathway_Homo sapiens_hsa041500.33643499
129Renal cell carcinoma_Homo sapiens_hsa052110.33361330
130Fructose and mannose metabolism_Homo sapiens_hsa000510.31786029
131Nucleotide excision repair_Homo sapiens_hsa034200.30755956
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30403628
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29849680
134Ovarian steroidogenesis_Homo sapiens_hsa049130.29786797
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.28500584
136Prion diseases_Homo sapiens_hsa050200.27473781
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.26937662
138Mineral absorption_Homo sapiens_hsa049780.26134191
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.25222738
140Endometrial cancer_Homo sapiens_hsa052130.24377421
141Wnt signaling pathway_Homo sapiens_hsa043100.23153489
142Bile secretion_Homo sapiens_hsa049760.23026170
143Melanoma_Homo sapiens_hsa052180.22672761
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21700880
145Endocytosis_Homo sapiens_hsa041440.20836516
146Parkinsons disease_Homo sapiens_hsa050120.20451110
147African trypanosomiasis_Homo sapiens_hsa051430.20257438

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