CDHR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily. The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent cell-cell adhesion molecules. This protocadherin represents a new candidate for tumor suppression. Alternatively spliced transcript variants that encode the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.09601195
2regulation of guanylate cyclase activity (GO:0031282)7.00873370
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.77408651
4fat-soluble vitamin biosynthetic process (GO:0042362)6.65566301
5vitamin A metabolic process (GO:0006776)6.62957838
6actin filament depolymerization (GO:0030042)6.00368953
7virion attachment to host cell (GO:0019062)5.87404450
8adhesion of symbiont to host cell (GO:0044650)5.87404450
9flavonoid metabolic process (GO:0009812)5.58565745
10drug catabolic process (GO:0042737)5.48844196
11fructose metabolic process (GO:0006000)5.46399070
12digestive system process (GO:0022600)5.46194161
13UDP-N-acetylglucosamine metabolic process (GO:0006047)5.31886162
14positive regulation of guanylate cyclase activity (GO:0031284)5.28689391
15regulation of bile acid biosynthetic process (GO:0070857)5.26396009
16purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.17238185
173-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.17238185
18cellular glucuronidation (GO:0052695)5.08423545
19phospholipid efflux (GO:0033700)5.05535128
20uronic acid metabolic process (GO:0006063)4.96579513
21glucuronate metabolic process (GO:0019585)4.96579513
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.96190798
23bundle of His cell to Purkinje myocyte communication (GO:0086069)4.96137233
24modified amino acid transport (GO:0072337)4.92581309
25urea metabolic process (GO:0019627)4.88048824
26urea cycle (GO:0000050)4.86688692
27plasma lipoprotein particle assembly (GO:0034377)4.79248341
28adhesion of symbiont to host (GO:0044406)4.78995715
29sulfate transmembrane transport (GO:1902358)4.78497675
30positive regulation of lipoprotein lipase activity (GO:0051006)4.72546653
31positive regulation of triglyceride lipase activity (GO:0061365)4.72546653
32regulation of cholesterol esterification (GO:0010872)4.70801574
33maintenance of gastrointestinal epithelium (GO:0030277)4.69372222
34protein-lipid complex assembly (GO:0065005)4.58003886
35bile acid and bile salt transport (GO:0015721)4.56481717
36lipoprotein metabolic process (GO:0042157)4.53579911
37regulation of triglyceride catabolic process (GO:0010896)4.49471598
38nitrogen cycle metabolic process (GO:0071941)4.47882269
39regulation of cellular extravasation (GO:0002691)4.47533194
40glucose 6-phosphate metabolic process (GO:0051156)4.35793712
41response to hepatocyte growth factor (GO:0035728)4.34818306
42cellular response to hepatocyte growth factor stimulus (GO:0035729)4.34818306
43digestion (GO:0007586)4.29629194
44regulation of cGMP biosynthetic process (GO:0030826)4.24209982
45receptor guanylyl cyclase signaling pathway (GO:0007168)4.23241275
46renal system process involved in regulation of blood volume (GO:0001977)4.22942740
47hormone catabolic process (GO:0042447)4.20859661
48cholesterol efflux (GO:0033344)4.19086151
49sulfur compound transport (GO:0072348)4.17655566
50lipoprotein transport (GO:0042953)4.12301115
51very-low-density lipoprotein particle assembly (GO:0034379)4.10516030
52negative regulation of cholesterol transport (GO:0032375)4.10474836
53negative regulation of sterol transport (GO:0032372)4.10474836
54peptide hormone processing (GO:0016486)4.04511542
55cholesterol homeostasis (GO:0042632)3.96611628
56sterol homeostasis (GO:0055092)3.94402237
57sulfate transport (GO:0008272)3.90484058
58peptide catabolic process (GO:0043171)3.88206598
59intestinal epithelial cell development (GO:0060576)3.87794280
60alkaloid metabolic process (GO:0009820)3.85982752
61drinking behavior (GO:0042756)3.85587244
62diacylglycerol metabolic process (GO:0046339)3.79962449
63vitamin transmembrane transport (GO:0035461)3.79247882
64regulation of cholesterol homeostasis (GO:2000188)3.76427382
65glycolipid catabolic process (GO:0019377)3.70343033
66oligosaccharide catabolic process (GO:0009313)3.69810995
67glycosphingolipid catabolic process (GO:0046479)3.68175784
68sterol transport (GO:0015918)3.66840976
69cholesterol transport (GO:0030301)3.66840976
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.66761031
71O-glycan processing (GO:0016266)3.66668804
72bile acid metabolic process (GO:0008206)3.66665030
73arginine metabolic process (GO:0006525)3.64530305
74bicarbonate transport (GO:0015701)3.62980976
75homocysteine metabolic process (GO:0050667)3.60607483
76regulation of vitamin metabolic process (GO:0030656)3.60183282
77epithelial structure maintenance (GO:0010669)3.59170383
78sulfation (GO:0051923)3.57474334
79antibacterial humoral response (GO:0019731)3.57207677
80glutamine family amino acid biosynthetic process (GO:0009084)3.53880425
81ethanol oxidation (GO:0006069)3.53821551
82vitamin transport (GO:0051180)3.53799145
83antimicrobial humoral response (GO:0019730)3.49191256
84regulation of cGMP metabolic process (GO:0030823)3.48880274
85drug transport (GO:0015893)3.48093260
86positive regulation of lipid catabolic process (GO:0050996)3.47404304
87reverse cholesterol transport (GO:0043691)3.47064943
88transcytosis (GO:0045056)3.46908482
89cellular response to nitric oxide (GO:0071732)3.46303421
90transepithelial transport (GO:0070633)3.45813239
91positive regulation of fatty acid biosynthetic process (GO:0045723)3.45012548
92regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.39396376
93regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.38527971
94endocrine process (GO:0050886)3.38527971
95regulation of systemic arterial blood pressure by hormone (GO:0001990)3.38527971
96renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.37847039
97vitamin biosynthetic process (GO:0009110)3.35898883
98fat-soluble vitamin metabolic process (GO:0006775)3.34892304
99purine nucleotide salvage (GO:0032261)3.34489524
100positive regulation of pseudopodium assembly (GO:0031274)3.33113620
101phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.32057252
102thyroid hormone metabolic process (GO:0042403)3.31607014
103drug transmembrane transport (GO:0006855)3.30239400
104positive regulation of T cell differentiation in thymus (GO:0033089)3.30184155
105sperm capacitation (GO:0048240)3.22552864
106omega-hydroxylase P450 pathway (GO:0097267)3.22186049
107sexual reproduction (GO:0019953)3.20306904
108negative regulation of digestive system process (GO:0060457)3.20234186
109positive regulation of glycoprotein biosynthetic process (GO:0010560)3.19200304
110exogenous drug catabolic process (GO:0042738)3.17217350
111glycerol metabolic process (GO:0006071)3.11380602
112proline metabolic process (GO:0006560)3.10699708
113response to nitric oxide (GO:0071731)3.09731721
114plasma lipoprotein particle remodeling (GO:0034369)3.09135984
115protein-lipid complex remodeling (GO:0034368)3.09135984
116macromolecular complex remodeling (GO:0034367)3.09135984
117high-density lipoprotein particle remodeling (GO:0034375)3.07764525
118midgut development (GO:0007494)3.06267537
119renal absorption (GO:0070293)3.05581282
120thrombin receptor signaling pathway (GO:0070493)3.04350243
121regulation of digestive system process (GO:0044058)3.04225723
122positive regulation of cGMP biosynthetic process (GO:0030828)3.03616251
123cGMP-mediated signaling (GO:0019934)3.03182820
124response to hydroperoxide (GO:0033194)3.02923321
125cellular response to reactive nitrogen species (GO:1902170)3.02797792
126NADH metabolic process (GO:0006734)3.02587237
127plasma lipoprotein particle organization (GO:0071827)3.00895033
128protein-lipid complex subunit organization (GO:0071825)3.00066209
129nucleoside diphosphate biosynthetic process (GO:0009133)2.98489493
130leukotriene metabolic process (GO:0006691)2.98354848
131regulation of actin nucleation (GO:0051125)2.96259160
132regulation of systemic arterial blood pressure (GO:0003073)2.95927349
133sphingomyelin metabolic process (GO:0006684)2.95891130
134striated muscle atrophy (GO:0014891)2.94245027
135polyol transport (GO:0015791)2.93889632
136positive regulation of triglyceride metabolic process (GO:0090208)2.92651798
137drug metabolic process (GO:0017144)2.88245631
138calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.87648227
139phospholipid homeostasis (GO:0055091)2.87279782
140regulation of cholesterol transport (GO:0032374)2.86746639
141regulation of sterol transport (GO:0032371)2.86746639
142lipid homeostasis (GO:0055088)2.84394783
143desmosome organization (GO:0002934)2.83206341
144cellular carbohydrate catabolic process (GO:0044275)2.81977252
145hydrogen peroxide catabolic process (GO:0042744)2.81637209
146intestinal absorption (GO:0050892)11.7893333
147intestinal cholesterol absorption (GO:0030299)10.9031365
148angiotensin maturation (GO:0002003)10.1300128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.02643041
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.39751548
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.74581116
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.20464014
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.06407966
6GATA4_25053715_ChIP-Seq_YYC3_Human3.04649002
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.84017319
8GATA6_25053715_ChIP-Seq_YYC3_Human2.78480846
9SOX2_20726797_ChIP-Seq_SW620_Human2.65264343
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.58490224
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.54903508
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.52243135
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.46836594
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.45781686
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.41764731
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.25737391
17PPAR_26484153_Chip-Seq_NCI-H1993_Human2.09457886
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94505712
19SRY_22984422_ChIP-ChIP_TESTIS_Rat1.94191608
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.85448970
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81910378
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74884950
23KLF5_25053715_ChIP-Seq_YYC3_Human1.74577399
24NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.70920253
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.67238566
26RUNX1_27514584_Chip-Seq_MCF-7_Human1.64977829
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.62345007
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59292801
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58958114
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.58489277
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56967788
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55886936
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55760838
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53667315
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51928287
36RACK7_27058665_Chip-Seq_MCF-7_Human1.51477821
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.50457355
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45400340
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.44470960
40GATA2_19941826_ChIP-Seq_K562_Human1.42536234
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39512639
42HNF4A_19822575_ChIP-Seq_HepG2_Human1.37038523
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36974124
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36099238
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34858251
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32082856
47ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.31934018
48ATF3_27146783_Chip-Seq_COLON_Human1.31758862
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28649512
50CLOCK_20551151_ChIP-Seq_293T_Human1.25211425
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.25147196
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23844884
53FOXA2_19822575_ChIP-Seq_HepG2_Human1.23076304
54VDR_22108803_ChIP-Seq_LS180_Human1.22109308
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21145621
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18001670
57SA1_27219007_Chip-Seq_Bcells_Human1.16547466
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16235168
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15384243
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12174538
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12016766
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11887574
63* BCOR_27268052_Chip-Seq_Bcells_Human1.11519472
64* BCL6_27268052_Chip-Seq_Bcells_Human1.11364688
65JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.11238849
66* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10930389
67* TET1_21451524_ChIP-Seq_MESCs_Mouse1.08881507
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06276091
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04987424
70AR_21909140_ChIP-Seq_LNCAP_Human1.02779947
71TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.02433151
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01727815
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01369676
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00486637
75JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00455287
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00429537
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00307487
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.00286418
79* CREB1_26743006_Chip-Seq_LNCaP_Human0.98561478
80DROSHA_22980978_ChIP-Seq_HELA_Human0.96426720
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96373730
82CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96150359
83EGR1_19032775_ChIP-ChIP_M12_Human0.96016610
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95840600
85GATA1_19941826_ChIP-Seq_K562_Human0.95311307
86NANOG_20526341_ChIP-Seq_ESCs_Human0.94520657
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94379227
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94363313
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93820205
90CEBPB_22108803_ChIP-Seq_LS180_Human0.93204691
91LXR_22292898_ChIP-Seq_THP-1_Human0.92721355
92GATA1_26923725_Chip-Seq_HPCs_Mouse0.91140694
93GATA1_22025678_ChIP-Seq_K562_Human0.91058344
94TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90707617
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89559883
96RXR_22108803_ChIP-Seq_LS180_Human0.87736552
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87315319
98SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87315319
99RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87247225
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.86062105
101GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85070114
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82856825
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82642199
104PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82172552
105GATA3_24758297_ChIP-Seq_MCF-7_Human0.81697693
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81474087
107EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.79997850
108* FOXA1_25552417_ChIP-Seq_VCAP_Human0.79895706
109FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79242571
110FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78888683
111STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.78361104
112ZNF263_19887448_ChIP-Seq_K562_Human0.77836461
113CDX2_22108803_ChIP-Seq_LS180_Human0.77827230
114CTCF_27219007_Chip-Seq_Bcells_Human0.77389087
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76827865
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76329459
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75924491
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75414151
119CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75163477
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74575403
121E2F1_20622854_ChIP-Seq_HELA_Human0.74467232
122* PHF8_20622854_ChIP-Seq_HELA_Human0.74189389
123SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74140067
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73891887
125NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.73839479
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.73295354
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73254478
128SOX2_22085726_ChIP-Seq_NPCs_Mouse0.73218987
129SOX9_24532713_ChIP-Seq_HFSC_Mouse0.73050383
130* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.73038354
131* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72909318
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72289636
133* TP63_22573176_ChIP-Seq_HFKS_Human0.71096285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.00990343
2MP0001666_abnormal_nutrient_absorption5.81072483
3MP0010234_abnormal_vibrissa_follicle4.70721826
4MP0004264_abnormal_extraembryonic_tissu3.87577948
5MP0009840_abnormal_foam_cell3.41804706
6MP0002139_abnormal_hepatobiliary_system3.39736347
7MP0005085_abnormal_gallbladder_physiolo3.30440082
8MP0003183_abnormal_peptide_metabolism3.26621193
9MP0003252_abnormal_bile_duct3.12740853
10MP0003866_abnormal_defecation3.07164112
11MP0000462_abnormal_digestive_system3.06070026
12MP0008875_abnormal_xenobiotic_pharmacok2.98740017
13MP0002822_catalepsy2.97558053
14MP0005377_hearing/vestibular/ear_phenot2.70622379
15MP0003878_abnormal_ear_physiology2.70622379
16MP0010329_abnormal_lipoprotein_level2.38259214
17MP0004043_abnormal_pH_regulation2.25224097
18MP0005409_darkened_coat_color2.17579909
19MP0005365_abnormal_bile_salt2.16876977
20MP0004019_abnormal_vitamin_homeostasis2.15618045
21MP0004147_increased_porphyrin_level2.07880777
22MP0001663_abnormal_digestive_system1.92959316
23MP0005381_digestive/alimentary_phenotyp1.92489350
24MP0010155_abnormal_intestine_physiology1.88187142
25MP0000537_abnormal_urethra_morphology1.86345508
26MP0003283_abnormal_digestive_organ1.81870869
27MP0005084_abnormal_gallbladder_morpholo1.79849935
28MP0001873_stomach_inflammation1.77747810
29MP0001664_abnormal_digestion1.76198381
30MP0000538_abnormal_urinary_bladder1.71945380
31MP0003300_gastrointestinal_ulcer1.70557601
32MP0000477_abnormal_intestine_morphology1.67165501
33MP0010352_gastrointestinal_tract_polyps1.66724281
34MP0003705_abnormal_hypodermis_morpholog1.65985401
35MP0005670_abnormal_white_adipose1.63101167
36MP0003191_abnormal_cellular_cholesterol1.60161090
37MP0000490_abnormal_crypts_of1.51747236
38MP0005167_abnormal_blood-brain_barrier1.45989978
39MP0006054_spinal_hemorrhage1.44285008
40MP0009643_abnormal_urine_homeostasis1.40054499
41MP0002796_impaired_skin_barrier1.38978806
42MP0005332_abnormal_amino_acid1.22438434
43MP0005448_abnormal_energy_balance1.19429827
44MP0001188_hyperpigmentation1.18540892
45MP0001765_abnormal_ion_homeostasis1.17131632
46MP0004858_abnormal_nervous_system1.14437625
47MP0002089_abnormal_postnatal_growth/wei1.08055468
48MP0002254_reproductive_system_inflammat1.07246217
49MP0004782_abnormal_surfactant_physiolog1.06325248
50MP0010678_abnormal_skin_adnexa1.05677807
51MP0002118_abnormal_lipid_homeostasis1.01006210
52MP0001849_ear_inflammation0.98707742
53MP0002971_abnormal_brown_adipose0.98519477
54MP0005636_abnormal_mineral_homeostasis0.96577506
55MP0002876_abnormal_thyroid_physiology0.95092963
56MP0009697_abnormal_copulation0.94447363
57MP0009379_abnormal_foot_pigmentation0.94201107
58MP0001501_abnormal_sleep_pattern0.93908257
59MP0000467_abnormal_esophagus_morphology0.93873691
60MP0005535_abnormal_body_temperature0.93321114
61MP0003806_abnormal_nucleotide_metabolis0.93108590
62MP0000609_abnormal_liver_physiology0.92327441
63MP0004947_skin_inflammation0.90014504
64MP0005501_abnormal_skin_physiology0.89313760
65MP0002098_abnormal_vibrissa_morphology0.86103984
66MP0009780_abnormal_chondrocyte_physiolo0.84991077
67MP0003868_abnormal_feces_composition0.83362109
68MP0009384_cardiac_valve_regurgitation0.80020468
69MP0002136_abnormal_kidney_physiology0.79899214
70MP0005451_abnormal_body_composition0.79057220
71MP0008469_abnormal_protein_level0.76950149
72MP0003453_abnormal_keratinocyte_physiol0.72602044
73MP0005166_decreased_susceptibility_to0.71920677
74MP0000516_abnormal_urinary_system0.71721012
75MP0005367_renal/urinary_system_phenotyp0.71721012
76MP0009053_abnormal_anal_canal0.71366895
77MP0009785_altered_susceptibility_to0.71134182
78MP0004270_analgesia0.70739932
79MP0008872_abnormal_physiological_respon0.70687141
80MP0005310_abnormal_salivary_gland0.67702265
81MP0000566_synostosis0.66909815
82MP0005666_abnormal_adipose_tissue0.66548129
83MP0005319_abnormal_enzyme/_coenzyme0.65706725
84MP0003329_amyloid_beta_deposits0.62754898
85MP0000249_abnormal_blood_vessel0.62111957
86MP0003315_abnormal_perineum_morphology0.62052974
87MP0001216_abnormal_epidermal_layer0.61828628
88MP0003879_abnormal_hair_cell0.61474855
89MP0005266_abnormal_metabolism0.60414907
90MP0001756_abnormal_urination0.60355852
91MP0003436_decreased_susceptibility_to0.58642659
92MP0001485_abnormal_pinna_reflex0.58349623
93MP0005058_abnormal_lysosome_morphology0.58168324
94MP0002166_altered_tumor_susceptibility0.56739178
95MP0003718_maternal_effect0.56699836
96MP0002078_abnormal_glucose_homeostasis0.56340463
97MP0000678_abnormal_parathyroid_gland0.55940505
98MP0005025_abnormal_response_to0.54655297
99MP0000465_gastrointestinal_hemorrhage0.54070050
100MP0005334_abnormal_fat_pad0.52944375
101MP0009642_abnormal_blood_homeostasis0.52926747
102MP0001764_abnormal_homeostasis0.52799417
103MP0005584_abnormal_enzyme/coenzyme_acti0.51683956
104MP0000470_abnormal_stomach_morphology0.51294084
105MP0003953_abnormal_hormone_level0.51195280
106MP0002896_abnormal_bone_mineralization0.50309079
107MP0009764_decreased_sensitivity_to0.49898548
108MP0002396_abnormal_hematopoietic_system0.49186859
109MP0003724_increased_susceptibility_to0.48160972
110MP0003303_peritoneal_inflammation0.47346031
111MP0003195_calcinosis0.47166308
112MP0009333_abnormal_splenocyte_physiolog0.44968872
113MP0001835_abnormal_antigen_presentation0.43060259
114MP0000230_abnormal_systemic_arterial0.42726011
115MP0001881_abnormal_mammary_gland0.42226531
116MP0006082_CNS_inflammation0.42140130
117MP0003941_abnormal_skin_development0.41810959
118MP0000377_abnormal_hair_follicle0.41410693
119MP0003638_abnormal_response/metabolism_0.41251034
120MP0000604_amyloidosis0.40961860
121MP0001191_abnormal_skin_condition0.40754927
122MP0008873_increased_physiological_sensi0.40527041
123MP0000598_abnormal_liver_morphology0.39854381
124MP0005376_homeostasis/metabolism_phenot0.39173750
125MP0008260_abnormal_autophagy0.38730369
126MP0003045_fibrosis0.37761506
127MP0002277_abnormal_respiratory_mucosa0.36105077
128MP0009115_abnormal_fat_cell0.35542620
129MP0003950_abnormal_plasma_membrane0.35356612
130MP0009765_abnormal_xenobiotic_induced0.34391935
131MP0001845_abnormal_inflammatory_respons0.34016392
132MP0000613_abnormal_salivary_gland0.31588442
133MP0010771_integument_phenotype0.31316503
134MP0002060_abnormal_skin_morphology0.31161407
135MP0002138_abnormal_hepatobiliary_system0.30662477

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)8.20203055
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.85171232
3Acanthocytosis (HP:0001927)5.87905141
4Hypobetalipoproteinemia (HP:0003563)5.56960507
5Malnutrition (HP:0004395)5.54503219
6Right ventricular cardiomyopathy (HP:0011663)5.29414561
7Hydroxyprolinuria (HP:0003080)5.17067196
8Abnormality of proline metabolism (HP:0010907)5.17067196
9Autoimmune thrombocytopenia (HP:0001973)5.12076179
10Conjugated hyperbilirubinemia (HP:0002908)4.79612898
11Cupped ribs (HP:0000887)4.66267613
12Systemic lupus erythematosus (HP:0002725)4.61720160
13Chronic diarrhea (HP:0002028)4.18941486
14Abdominal distention (HP:0003270)4.03882908
15Fat malabsorption (HP:0002630)3.96365022
16Autoimmune hemolytic anemia (HP:0001890)3.82392388
17Widely patent fontanelles and sutures (HP:0004492)3.61044649
18Flat acetabular roof (HP:0003180)3.59778363
19Hyperactive renin-angiotensin system (HP:0000841)3.53718075
20Poikilocytosis (HP:0004447)3.47951433
21Hyperglycinuria (HP:0003108)3.45373631
22Hypolipoproteinemia (HP:0010981)3.41142629
23Nausea (HP:0002018)3.36108635
24Pigmentary retinal degeneration (HP:0001146)3.35590988
25Dehydration (HP:0001944)3.16324479
26Metabolic alkalosis (HP:0200114)3.14013875
27Abnormality of the vitamin B12 metabolism (HP:0004341)3.07937098
28Complement deficiency (HP:0004431)3.07817455
29Hemorrhage of the eye (HP:0011885)3.07369981
30Decreased circulating renin level (HP:0003351)3.05241875
31Steatorrhea (HP:0002570)2.99892084
32Gastrointestinal dysmotility (HP:0002579)2.99596112
33Abnormality of urine glucose concentration (HP:0011016)2.99463696
34Glycosuria (HP:0003076)2.99463696
35Increased purine levels (HP:0004368)2.99455856
36Hyperuricemia (HP:0002149)2.99455856
37Alkalosis (HP:0001948)2.98608718
38Abnormality of chloride homeostasis (HP:0011422)2.98140343
39Hypophosphatemia (HP:0002148)2.96105852
40Abnormality of the 1st metacarpal (HP:0010009)2.94813761
41Abnormality of small intestinal villus morphology (HP:0011472)2.94655734
42Villous atrophy (HP:0011473)2.94655734
43Abnormality of vitamin B metabolism (HP:0004340)2.89893205
44Facial shape deformation (HP:0011334)2.87589960
45Potter facies (HP:0002009)2.87589960
46Abnormality of complement system (HP:0005339)2.86903222
47Mesangial abnormality (HP:0001966)2.81984783
48Increased IgE level (HP:0003212)2.80846984
49Xanthomatosis (HP:0000991)2.78298007
50Hyperammonemia (HP:0001987)2.77611330
51Glomerulonephritis (HP:0000099)2.73282901
52Nephrolithiasis (HP:0000787)2.69064587
53Mildly elevated creatine phosphokinase (HP:0008180)2.66791842
54Abnormality of purine metabolism (HP:0004352)2.66770092
55Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.62293776
56Abnormal tarsal ossification (HP:0008369)2.61747940
57Focal segmental glomerulosclerosis (HP:0000097)2.58409946
58Intrahepatic cholestasis (HP:0001406)2.57207474
59Pustule (HP:0200039)2.56191110
60Abnormality of monocarboxylic acid metabolism (HP:0010996)2.53510087
61Enlarged epiphyses (HP:0010580)2.48677122
62Hypotension (HP:0002615)2.44286353
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.43931547
64Progressive sensorineural hearing impairment (HP:0000408)2.43790092
65Abnormality of vitamin metabolism (HP:0100508)2.42627487
66Posterior subcapsular cataract (HP:0007787)2.38813175
67Confusion (HP:0001289)2.37516975
68Delayed epiphyseal ossification (HP:0002663)2.36002941
69Abnormality of serine family amino acid metabolism (HP:0010894)2.35835282
70Abnormality of glycine metabolism (HP:0010895)2.35835282
71Abnormality of the distal phalanx of the thumb (HP:0009617)2.35337295
72Gout (HP:0001997)2.34248243
73Hypercholesterolemia (HP:0003124)2.34231227
74Abnormality of the gastric mucosa (HP:0004295)2.31129029
75Abnormal biliary tract morphology (HP:0012440)2.31116206
76Eczematoid dermatitis (HP:0000976)2.29317799
77Milia (HP:0001056)2.29255932
78B lymphocytopenia (HP:0010976)2.28757352
79Abnormality of B cell number (HP:0010975)2.28757352
80Nephritis (HP:0000123)2.28618197
81Abnormal glucose tolerance (HP:0001952)2.27088378
82Congenital sensorineural hearing impairment (HP:0008527)2.26085863
83Palpitations (HP:0001962)2.25457294
84Woolly hair (HP:0002224)2.24986427
85Abnormality of carpal bone ossification (HP:0006257)2.24789766
86Hyperphosphaturia (HP:0003109)2.24688474
87Wide cranial sutures (HP:0010537)2.23254041
88Protuberant abdomen (HP:0001538)2.22816888
89Abnormality of sulfur amino acid metabolism (HP:0004339)2.22342328
90Abnormality of pyrimidine metabolism (HP:0004353)2.20280205
91Severe combined immunodeficiency (HP:0004430)2.19729100
92Reticulocytosis (HP:0001923)2.19134325
93Increased mean platelet volume (HP:0011877)2.18581607
94Pili torti (HP:0003777)2.17346697
95Syncope (HP:0001279)2.16628347
96Abnormality of the costochondral junction (HP:0000919)2.14851277
97Hyperparathyroidism (HP:0000843)2.14507110
98Cerebral palsy (HP:0100021)2.10615326
99Symptomatic seizures (HP:0011145)2.08007824
100Combined immunodeficiency (HP:0005387)2.07535396
101Thin bony cortex (HP:0002753)2.07457123
102Progressive hearing impairment (HP:0001730)2.06622745
103Rectal prolapse (HP:0002035)2.05242007
104Metabolic acidosis (HP:0001942)2.03753839
105Subcapsular cataract (HP:0000523)2.03418442
106Abnormality of renin-angiotensin system (HP:0000847)2.02616011
107Glomerulosclerosis (HP:0000096)2.00674880
108Epidermoid cyst (HP:0200040)2.00530757
109Renal tubular acidosis (HP:0001947)2.00259761
110Pancreatitis (HP:0001733)2.00042649
111Abnormality of nucleobase metabolism (HP:0010932)1.98437440
112Proximal tubulopathy (HP:0000114)1.98101879
113Myopathic facies (HP:0002058)1.97781606
114Gingivitis (HP:0000230)1.96854436
115Short phalanx of the thumb (HP:0009660)1.96013182
116Abnormal urine phosphate concentration (HP:0012599)1.95692328
117Abnormal foot bone ossification (HP:0010675)1.94530218
118Dicarboxylic aciduria (HP:0003215)1.92624096
119Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92624096
120Irritability (HP:0000737)1.92323364
121Flattened epiphyses (HP:0003071)1.91358879
122Micronodular cirrhosis (HP:0001413)1.91050004
123Deep venous thrombosis (HP:0002625)1.90337922
124Goiter (HP:0000853)1.90301102
125Hyperphosphatemia (HP:0002905)1.89691008
126Fragile nails (HP:0001808)1.89128554
127Symphalangism affecting the phalanges of the hand (HP:0009773)1.88421178
128Abnormal enzyme/coenzyme activity (HP:0012379)1.87977556
129Rickets (HP:0002748)1.87683924
130Abnormality of alkaline phosphatase activity (HP:0004379)1.87464705
131Abnormal platelet volume (HP:0011876)1.87130420
132Alopecia of scalp (HP:0002293)1.87088752
133Polycythemia (HP:0001901)1.85520658
134Thyroiditis (HP:0100646)1.85092266
135Megaloblastic anemia (HP:0001889)1.83814085
136Late onset (HP:0003584)1.83204325
137Biliary tract neoplasm (HP:0100574)1.80092163
138Neonatal short-limb short stature (HP:0008921)1.79071792
139Growth hormone excess (HP:0000845)1.78477243
140Abnormality of magnesium homeostasis (HP:0004921)1.75946167
141Multiple lipomas (HP:0001012)1.75061457
142Hypophosphatemic rickets (HP:0004912)1.75017629
143Renal tubular dysfunction (HP:0000124)1.72287770
144Skin nodule (HP:0200036)1.68145652
145Generalized aminoaciduria (HP:0002909)1.65496859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.39462184
2FRK6.26158638
3MST1R5.56061428
4MST45.30521128
5LMTK24.45559105
6NME13.15306396
7PRKG23.05903930
8GRK62.97688691
9RIPK12.85431758
10MAP2K22.69205390
11PIK3CA2.43002700
12EPHA22.32631941
13MAP3K22.31405634
14MAP3K102.20251677
15AKT32.13742186
16PTK62.08379538
17EPHB22.02918020
18MET2.01897920
19TESK11.64176775
20NUAK11.61237543
21EPHA31.61173081
22ERN11.53794596
23FGFR31.47645132
24TAOK31.34794759
25KSR21.34161392
26STK101.26637667
27MYLK1.26394410
28TNIK1.26184298
29EPHA41.21892533
30TAOK11.18413238
31PRPF4B1.17776341
32PRKCI1.07788331
33TESK21.06080716
34PTK21.05414501
35MAP3K71.03347405
36RIPK40.97768660
37EPHB10.95979387
38MAP2K10.95859749
39WNK40.94796676
40DDR20.94708305
41MAP3K80.91714053
42FER0.90930358
43STK240.89867324
44MATK0.89683425
45ERBB20.84843818
46PAK40.82556310
47NLK0.81906906
48PRKAA20.80981509
49MAP3K110.80756195
50TRIB30.77340873
51MAP3K10.76768719
52DMPK0.76735024
53TTK0.76645087
54MAP2K60.74144091
55BMX0.71843932
56LATS10.71516537
57MAPK110.67971729
58SCYL20.62922597
59PRKCZ0.62204286
60RET0.59901723
61OXSR10.57336156
62MAP3K120.56065302
63ICK0.55690242
64CASK0.52116351
65MAP3K30.51394741
66PDPK10.51114544
67LIMK10.49769051
68IRAK10.49313552
69CAMK2D0.49222255
70JAK10.47136228
71LRRK20.46851688
72CSF1R0.46033467
73PRKAA10.45922523
74PAK30.44846057
75PIM10.42412007
76MAP3K90.42345435
77TBK10.42058549
78YES10.40354809
79DYRK1B0.39929917
80PBK0.39311378
81EEF2K0.38915090
82GRK10.38715196
83ZAP700.38517980
84JAK20.38039875
85ABL20.35368888
86PDK10.35239507
87PDK20.35063119
88CSK0.34652694
89PRKCA0.32189433
90SRC0.30921936
91STK390.30644407
92SIK10.29091887
93PKN20.28608422
94WNK30.28362114
95ROCK10.28114515
96DAPK20.27620561
97IKBKE0.26594786
98SYK0.26558731
99BMPR20.26383923
100MAP3K140.26254948
101INSRR0.25458920
102IGF1R0.25453816
103SMG10.25428334
104CSNK1A10.25410285
105ITK0.25017961
106PAK20.24781668
107STK110.23699871
108AURKB0.22988779
109PRKACG0.22104971
110PAK10.22080918
111RPS6KA20.21149691
112STK30.20921080
113MAPKAPK20.20537489
114ERBB40.19708256
115NEK60.19598548
116CAMK2G0.19260967
117FYN0.18610075
118BTK0.18607769
119LYN0.18419920
120IRAK30.18405155
121MELK0.18081048
122PRKACA0.17589304
123FGFR40.17547692
124PIM20.16859776
125TYK20.16799536
126GSK3A0.16643887
127CAMK2B0.16043478
128AKT20.15680496
129PRKCD0.15646948
130CDK90.14626653
131CDK60.14622107
132PRKCQ0.13337069
133MAP4K10.12994103
134PDGFRA0.12120284
135CDC42BPA0.09894667

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.56173286
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.54185589
3Mineral absorption_Homo sapiens_hsa049784.36716564
4Renin-angiotensin system_Homo sapiens_hsa046144.20043805
5Vitamin digestion and absorption_Homo sapiens_hsa049773.80737711
6Sulfur metabolism_Homo sapiens_hsa009203.47620256
7Galactose metabolism_Homo sapiens_hsa000522.67943953
8Caffeine metabolism_Homo sapiens_hsa002322.64572496
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.54571592
10Bile secretion_Homo sapiens_hsa049762.47909787
11Starch and sucrose metabolism_Homo sapiens_hsa005002.43484843
12Protein digestion and absorption_Homo sapiens_hsa049742.33097577
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.15909763
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.10892705
15Folate biosynthesis_Homo sapiens_hsa007902.02708948
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83957938
17Fructose and mannose metabolism_Homo sapiens_hsa000511.83244041
18Histidine metabolism_Homo sapiens_hsa003401.77878026
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.69294514
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62148126
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.45716784
22PPAR signaling pathway_Homo sapiens_hsa033201.40833680
23Tryptophan metabolism_Homo sapiens_hsa003801.34767959
24Glycerolipid metabolism_Homo sapiens_hsa005611.32654814
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31274992
26Glutathione metabolism_Homo sapiens_hsa004801.23559036
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16781441
28Sphingolipid metabolism_Homo sapiens_hsa006001.10840950
29Fatty acid degradation_Homo sapiens_hsa000711.08778514
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02273444
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99626894
32Arginine biosynthesis_Homo sapiens_hsa002200.98718312
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95768346
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94368587
35ABC transporters_Homo sapiens_hsa020100.90726762
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89246731
37Arginine and proline metabolism_Homo sapiens_hsa003300.89116742
38Nitrogen metabolism_Homo sapiens_hsa009100.84026511
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83400556
40Primary bile acid biosynthesis_Homo sapiens_hsa001200.81527103
41Staphylococcus aureus infection_Homo sapiens_hsa051500.80652693
42Asthma_Homo sapiens_hsa053100.76604349
43Tight junction_Homo sapiens_hsa045300.75796194
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75629881
45Thyroid hormone synthesis_Homo sapiens_hsa049180.75210503
46Complement and coagulation cascades_Homo sapiens_hsa046100.72222545
47Tyrosine metabolism_Homo sapiens_hsa003500.69451808
48Pyruvate metabolism_Homo sapiens_hsa006200.69002895
49Pancreatic secretion_Homo sapiens_hsa049720.68724643
50Butanoate metabolism_Homo sapiens_hsa006500.68229653
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.65833931
52Carbon metabolism_Homo sapiens_hsa012000.63487336
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58195040
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56572906
55Allograft rejection_Homo sapiens_hsa053300.54963998
56beta-Alanine metabolism_Homo sapiens_hsa004100.54015719
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52885469
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.52759680
59Pentose phosphate pathway_Homo sapiens_hsa000300.52389056
60Linoleic acid metabolism_Homo sapiens_hsa005910.50390986
61Autoimmune thyroid disease_Homo sapiens_hsa053200.50359757
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49770598
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47897442
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47128860
65Graft-versus-host disease_Homo sapiens_hsa053320.46619591
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45394663
67Chemical carcinogenesis_Homo sapiens_hsa052040.44420394
68Type II diabetes mellitus_Homo sapiens_hsa049300.43281177
69Arachidonic acid metabolism_Homo sapiens_hsa005900.39243949
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39228278
71Retinol metabolism_Homo sapiens_hsa008300.38715433
72Gastric acid secretion_Homo sapiens_hsa049710.38672614
73Fatty acid metabolism_Homo sapiens_hsa012120.38528289
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.36426286
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.36198424
76Type I diabetes mellitus_Homo sapiens_hsa049400.35166871
77Peroxisome_Homo sapiens_hsa041460.34538561
78Salmonella infection_Homo sapiens_hsa051320.34432605
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.33834454
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33683236
81Thyroid cancer_Homo sapiens_hsa052160.30606568
82Bladder cancer_Homo sapiens_hsa052190.30503975
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29552967
84Selenocompound metabolism_Homo sapiens_hsa004500.29551798
85Hepatitis C_Homo sapiens_hsa051600.29105258
86Salivary secretion_Homo sapiens_hsa049700.28732425
87Metabolic pathways_Homo sapiens_hsa011000.27889729
88Adherens junction_Homo sapiens_hsa045200.26538819
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.25239561
90African trypanosomiasis_Homo sapiens_hsa051430.24873224
91Ether lipid metabolism_Homo sapiens_hsa005650.22051793
92Glucagon signaling pathway_Homo sapiens_hsa049220.21041314
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20767524
94Lysine degradation_Homo sapiens_hsa003100.20183814
95Biosynthesis of amino acids_Homo sapiens_hsa012300.18217827
96Steroid biosynthesis_Homo sapiens_hsa001000.18092690
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17853079
98Pertussis_Homo sapiens_hsa051330.17814086
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17767630
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17714125
101Insulin secretion_Homo sapiens_hsa049110.17057621
102Antigen processing and presentation_Homo sapiens_hsa046120.16906565
103Cocaine addiction_Homo sapiens_hsa050300.16666032
104Sulfur relay system_Homo sapiens_hsa041220.15786145
105Vibrio cholerae infection_Homo sapiens_hsa051100.14734431
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13678253
107Leishmaniasis_Homo sapiens_hsa051400.13608406
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.13202026
109Inositol phosphate metabolism_Homo sapiens_hsa005620.11518652
110Propanoate metabolism_Homo sapiens_hsa006400.11031356
111Renin secretion_Homo sapiens_hsa049240.10766159
112Insulin resistance_Homo sapiens_hsa049310.10379489
113Phenylalanine metabolism_Homo sapiens_hsa003600.10160724
114GnRH signaling pathway_Homo sapiens_hsa049120.09891678
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.08872209
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.07711704
117Fatty acid biosynthesis_Homo sapiens_hsa000610.07619303
118Choline metabolism in cancer_Homo sapiens_hsa052310.07525945
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.06863771
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.04080929
121AMPK signaling pathway_Homo sapiens_hsa041520.03622090
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.02865536
123Other glycan degradation_Homo sapiens_hsa005110.02751874
124Serotonergic synapse_Homo sapiens_hsa047260.01563490

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