

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | sodium ion export (GO:0071436) | 5.64072942 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.91239431 |
| 3 | synaptic vesicle exocytosis (GO:0016079) | 4.70184318 |
| 4 | glutamate secretion (GO:0014047) | 4.48837222 |
| 5 | vocalization behavior (GO:0071625) | 4.42208203 |
| 6 | synaptic vesicle maturation (GO:0016188) | 4.40836520 |
| 7 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.39054321 |
| 8 | neuronal action potential propagation (GO:0019227) | 4.34479530 |
| 9 | neuron cell-cell adhesion (GO:0007158) | 4.26896813 |
| 10 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.25605593 |
| 11 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.24476382 |
| 12 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.23937638 |
| 13 | amino acid import (GO:0043090) | 4.13725620 |
| 14 | locomotory exploration behavior (GO:0035641) | 4.03978259 |
| 15 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.02487972 |
| 16 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.00443698 |
| 17 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.99440147 |
| 18 | protein localization to synapse (GO:0035418) | 3.95966790 |
| 19 | positive regulation of dendritic spine development (GO:0060999) | 3.95965111 |
| 20 | cell communication by electrical coupling (GO:0010644) | 3.95336459 |
| 21 | neurotransmitter secretion (GO:0007269) | 3.92287662 |
| 22 | gamma-aminobutyric acid transport (GO:0015812) | 3.90947931 |
| 23 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.89893937 |
| 24 | regulation of synapse maturation (GO:0090128) | 3.83004482 |
| 25 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.82903017 |
| 26 | potassium ion import (GO:0010107) | 3.81869787 |
| 27 | potassium ion homeostasis (GO:0055075) | 3.81361714 |
| 28 | regulation of synaptic vesicle transport (GO:1902803) | 3.79739947 |
| 29 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.77392889 |
| 30 | neuromuscular process controlling balance (GO:0050885) | 3.72925995 |
| 31 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.72831187 |
| 32 | presynaptic membrane organization (GO:0097090) | 3.62718350 |
| 33 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.62666942 |
| 34 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.61622585 |
| 35 | axon ensheathment in central nervous system (GO:0032291) | 3.61390148 |
| 36 | central nervous system myelination (GO:0022010) | 3.61390148 |
| 37 | presynaptic membrane assembly (GO:0097105) | 3.61189037 |
| 38 | neuron-neuron synaptic transmission (GO:0007270) | 3.59878744 |
| 39 | synaptic transmission, glutamatergic (GO:0035249) | 3.58410514 |
| 40 | cellular sodium ion homeostasis (GO:0006883) | 3.56942377 |
| 41 | regulation of ARF protein signal transduction (GO:0032012) | 3.51148979 |
| 42 | glutamate receptor signaling pathway (GO:0007215) | 3.50451509 |
| 43 | neurotransmitter uptake (GO:0001504) | 3.49345670 |
| 44 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.43040418 |
| 45 | acidic amino acid transport (GO:0015800) | 3.38583087 |
| 46 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.35934822 |
| 47 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.35480454 |
| 48 | neurotransmitter transport (GO:0006836) | 3.30119623 |
| 49 | exploration behavior (GO:0035640) | 3.29926063 |
| 50 | dendritic spine organization (GO:0097061) | 3.23155145 |
| 51 | cerebellar granule cell differentiation (GO:0021707) | 3.20535311 |
| 52 | neuron recognition (GO:0008038) | 3.19625987 |
| 53 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.18971002 |
| 54 | long-term memory (GO:0007616) | 3.18211592 |
| 55 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.15555726 |
| 56 | synaptic vesicle transport (GO:0048489) | 3.11699992 |
| 57 | establishment of synaptic vesicle localization (GO:0097480) | 3.11699992 |
| 58 | regulation of neurotransmitter levels (GO:0001505) | 3.10965290 |
| 59 | long-term synaptic potentiation (GO:0060291) | 3.10941612 |
| 60 | neuromuscular process controlling posture (GO:0050884) | 3.09832611 |
| 61 | transmission of nerve impulse (GO:0019226) | 3.08199999 |
| 62 | establishment of mitochondrion localization (GO:0051654) | 3.05980217 |
| 63 | positive regulation of membrane potential (GO:0045838) | 3.04688913 |
| 64 | L-glutamate transport (GO:0015813) | 3.04428766 |
| 65 | cerebellar Purkinje cell layer development (GO:0021680) | 3.03723942 |
| 66 | regulation of synapse structural plasticity (GO:0051823) | 3.03553638 |
| 67 | regulation of dendritic spine development (GO:0060998) | 3.01274729 |
| 68 | regulation of postsynaptic membrane potential (GO:0060078) | 2.99763438 |
| 69 | regulation of synaptic plasticity (GO:0048167) | 2.99098069 |
| 70 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.98885522 |
| 71 | positive regulation of synapse maturation (GO:0090129) | 2.98870803 |
| 72 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.98211297 |
| 73 | postsynaptic membrane organization (GO:0001941) | 2.98129286 |
| 74 | behavioral response to cocaine (GO:0048148) | 2.96374641 |
| 75 | vesicle docking involved in exocytosis (GO:0006904) | 2.95993985 |
| 76 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.95641254 |
| 77 | glycine transport (GO:0015816) | 2.95513318 |
| 78 | detection of calcium ion (GO:0005513) | 2.95070642 |
| 79 | dicarboxylic acid transport (GO:0006835) | 2.93769347 |
| 80 | regulation of exocytosis (GO:0017157) | 2.91717277 |
| 81 | intraspecies interaction between organisms (GO:0051703) | 2.90856654 |
| 82 | social behavior (GO:0035176) | 2.90856654 |
| 83 | regulation of neurotransmitter secretion (GO:0046928) | 2.90302794 |
| 84 | axonal fasciculation (GO:0007413) | 2.89654380 |
| 85 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.89487513 |
| 86 | neuromuscular synaptic transmission (GO:0007274) | 2.89134274 |
| 87 | prepulse inhibition (GO:0060134) | 2.88008685 |
| 88 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.87785547 |
| 89 | cellular potassium ion homeostasis (GO:0030007) | 2.87712120 |
| 90 | proline transport (GO:0015824) | 2.86887526 |
| 91 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.86797364 |
| 92 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.84588917 |
| 93 | adult walking behavior (GO:0007628) | 2.83654733 |
| 94 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.82527070 |
| 95 | synaptic vesicle endocytosis (GO:0048488) | 2.81937969 |
| 96 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.81144849 |
| 97 | neuronal ion channel clustering (GO:0045161) | 2.80656761 |
| 98 | dendritic spine morphogenesis (GO:0060997) | 2.78509950 |
| 99 | auditory behavior (GO:0031223) | 2.77682378 |
| 100 | activation of protein kinase A activity (GO:0034199) | 2.76848918 |
| 101 | regulation of neurotransmitter transport (GO:0051588) | 2.75892939 |
| 102 | layer formation in cerebral cortex (GO:0021819) | 2.75272720 |
| 103 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.73488436 |
| 104 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.73229980 |
| 105 | regulation of vesicle fusion (GO:0031338) | 2.71849788 |
| 106 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.71516138 |
| 107 | regulation of glutamate secretion (GO:0014048) | 2.71283715 |
| 108 | female mating behavior (GO:0060180) | 2.71203066 |
| 109 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.70450258 |
| 110 | mechanosensory behavior (GO:0007638) | 2.70131965 |
| 111 | striatum development (GO:0021756) | 2.69196009 |
| 112 | membrane hyperpolarization (GO:0060081) | 2.68723919 |
| 113 | regulation of female receptivity (GO:0045924) | 2.68156395 |
| 114 | membrane depolarization (GO:0051899) | 2.67405454 |
| 115 | negative regulation of neurotransmitter transport (GO:0051589) | 2.65872182 |
| 116 | membrane depolarization during action potential (GO:0086010) | 2.65681153 |
| 117 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.64729217 |
| 118 | regulation of synaptic transmission (GO:0050804) | 2.64417995 |
| 119 | synaptic transmission (GO:0007268) | 2.63950548 |
| 120 | L-amino acid import (GO:0043092) | 2.62728955 |
| 121 | positive regulation of synaptic transmission (GO:0050806) | 2.62376770 |
| 122 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.62256904 |
| 123 | learning (GO:0007612) | 2.60119886 |
| 124 | response to auditory stimulus (GO:0010996) | 2.59220416 |
| 125 | startle response (GO:0001964) | 2.58974919 |
| 126 | mating behavior (GO:0007617) | 2.56501841 |
| 127 | positive regulation of neurotransmitter transport (GO:0051590) | 2.53676782 |
| 128 | synapse assembly (GO:0007416) | 2.52577320 |
| 129 | dendrite morphogenesis (GO:0048813) | 2.52127761 |
| 130 | behavioral defense response (GO:0002209) | 2.51536115 |
| 131 | behavioral fear response (GO:0001662) | 2.51536115 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.91967769 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.73679336 |
| 3 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 3.14802213 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.00415418 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.94933452 |
| 6 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.78682707 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.56305438 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.56305438 |
| 9 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.46620689 |
| 10 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.44065688 |
| 11 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.41712965 |
| 12 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.40489921 |
| 13 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.40169793 |
| 14 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.39732980 |
| 15 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.37156664 |
| 16 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.37055032 |
| 17 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.27894474 |
| 18 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.22500416 |
| 19 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.19528866 |
| 20 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.17000260 |
| 21 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.15043385 |
| 22 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.14230520 |
| 23 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 2.13397269 |
| 24 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.11677868 |
| 25 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 2.08750044 |
| 26 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.05314934 |
| 27 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.98933688 |
| 28 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.88665170 |
| 29 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.86586145 |
| 30 | KDM2B_26808549_Chip-Seq_K562_Human | 1.83855362 |
| 31 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.81882659 |
| 32 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.77404849 |
| 33 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.76840802 |
| 34 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.76025648 |
| 35 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.75610043 |
| 36 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.75369497 |
| 37 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.74957277 |
| 38 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.70041766 |
| 39 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.67913153 |
| 40 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.62453453 |
| 41 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.59327186 |
| 42 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.59243023 |
| 43 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.58530534 |
| 44 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.57413519 |
| 45 | P68_20966046_ChIP-Seq_HELA_Human | 1.50589356 |
| 46 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.50244671 |
| 47 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.49267856 |
| 48 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.48029392 |
| 49 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.46786828 |
| 50 | P300_19829295_ChIP-Seq_ESCs_Human | 1.44333153 |
| 51 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.43850507 |
| 52 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.43624364 |
| 53 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.43516965 |
| 54 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.43329399 |
| 55 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.40170026 |
| 56 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.40165597 |
| 57 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.39084904 |
| 58 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.38740043 |
| 59 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.35422982 |
| 60 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.34467514 |
| 61 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.34020028 |
| 62 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.33983939 |
| 63 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.32424727 |
| 64 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.32296055 |
| 65 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.30660909 |
| 66 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.28788331 |
| 67 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.28488358 |
| 68 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.26273787 |
| 69 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.26076784 |
| 70 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.25569843 |
| 71 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.24670740 |
| 72 | AR_25329375_ChIP-Seq_VCAP_Human | 1.20736840 |
| 73 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.20719997 |
| 74 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.20277431 |
| 75 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.20213831 |
| 76 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.18870514 |
| 77 | VDR_22108803_ChIP-Seq_LS180_Human | 1.18533558 |
| 78 | STAT3_23295773_ChIP-Seq_U87_Human | 1.17474026 |
| 79 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.17148923 |
| 80 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.16036018 |
| 81 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.15630546 |
| 82 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.15586604 |
| 83 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.15002132 |
| 84 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.14918358 |
| 85 | KLF4_19829295_ChIP-Seq_ESCs_Human | 1.14901061 |
| 86 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.13452622 |
| 87 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.13050873 |
| 88 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.11763676 |
| 89 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.11179894 |
| 90 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.10825254 |
| 91 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.10648312 |
| 92 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.10256545 |
| 93 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.09442790 |
| 94 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.08878664 |
| 95 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.08148678 |
| 96 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.06291245 |
| 97 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.05497195 |
| 98 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 1.05491828 |
| 99 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.05411366 |
| 100 | AR_19668381_ChIP-Seq_PC3_Human | 1.04995515 |
| 101 | TCF4_23295773_ChIP-Seq_U87_Human | 1.04452559 |
| 102 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.03546599 |
| 103 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.03302930 |
| 104 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.03022317 |
| 105 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.02734093 |
| 106 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.02527772 |
| 107 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.02489371 |
| 108 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.01981021 |
| 109 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.01517771 |
| 110 | SA1_27219007_Chip-Seq_Bcells_Human | 1.01362387 |
| 111 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.98350341 |
| 112 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.97589372 |
| 113 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.97179093 |
| 114 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96747715 |
| 115 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.96177757 |
| 116 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.95219397 |
| 117 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 0.94711211 |
| 118 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.94410362 |
| 119 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.93508028 |
| 120 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.92582663 |
| 121 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.91184807 |
| 122 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.90308478 |
| 123 | FUS_26573619_Chip-Seq_HEK293_Human | 0.90305919 |
| 124 | SMAD4_21741376_ChIP-Seq_ESCs_Human | 0.89999419 |
| 125 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.89778244 |
| 126 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.88612437 |
| 127 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.88325042 |
| 128 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.87956925 |
| 129 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.87601826 |
| 130 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.87449450 |
| 131 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.86865809 |
| 132 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.86659844 |
| 133 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.85607626 |
| 134 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.85572748 |
| 135 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.84288478 |
| 136 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.83959169 |
| 137 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.83532136 |
| 138 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.83339713 |
| 139 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.82550498 |
| 140 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.82498991 |
| 141 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.82341502 |
| 142 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.81858804 |
| 143 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.81858804 |
| 144 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.81712696 |
| 145 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.80700978 |
| 146 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.80527485 |
| 147 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.80065113 |
| 148 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.79741850 |
| 149 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.79263539 |
| 150 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.79238936 |
| 151 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.78649219 |
| 152 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 0.78125828 |
| 153 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.77910567 |
| 154 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.77882103 |
| 155 | SOX3_22085726_ChIP-Seq_NPCs_Mouse | 0.76735122 |
| 156 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.76481111 |
| 157 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.75787282 |
| 158 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.72751711 |
| 159 | FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.72193978 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.12789185 |
| 2 | MP0003880_abnormal_central_pattern | 4.74962830 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.57632200 |
| 4 | MP0004270_analgesia | 3.14042201 |
| 5 | MP0009046_muscle_twitch | 3.13933811 |
| 6 | MP0009745_abnormal_behavioral_response | 3.13881459 |
| 7 | MP0002064_seizures | 3.12695103 |
| 8 | MP0002063_abnormal_learning/memory/cond | 2.84872927 |
| 9 | MP0002272_abnormal_nervous_system | 2.68600135 |
| 10 | MP0002822_catalepsy | 2.61668053 |
| 11 | MP0001486_abnormal_startle_reflex | 2.53759898 |
| 12 | MP0002572_abnormal_emotion/affect_behav | 2.53561997 |
| 13 | MP0005423_abnormal_somatic_nervous | 2.53256510 |
| 14 | MP0001968_abnormal_touch/_nociception | 2.53169216 |
| 15 | MP0002734_abnormal_mechanical_nocicepti | 2.28077703 |
| 16 | MP0002736_abnormal_nociception_after | 2.15378178 |
| 17 | MP0009780_abnormal_chondrocyte_physiolo | 1.99868484 |
| 18 | MP0001501_abnormal_sleep_pattern | 1.98731321 |
| 19 | MP0005646_abnormal_pituitary_gland | 1.98232406 |
| 20 | MP0001440_abnormal_grooming_behavior | 1.92248533 |
| 21 | MP0002067_abnormal_sensory_capabilities | 1.90715124 |
| 22 | MP0003329_amyloid_beta_deposits | 1.89625280 |
| 23 | MP0002735_abnormal_chemical_nociception | 1.80489545 |
| 24 | MP0008569_lethality_at_weaning | 1.78606631 |
| 25 | MP0001984_abnormal_olfaction | 1.76580833 |
| 26 | MP0001529_abnormal_vocalization | 1.75032079 |
| 27 | MP0004142_abnormal_muscle_tone | 1.72380029 |
| 28 | MP0000778_abnormal_nervous_system | 1.68254699 |
| 29 | MP0002733_abnormal_thermal_nociception | 1.67308443 |
| 30 | MP0006276_abnormal_autonomic_nervous | 1.66810471 |
| 31 | MP0001970_abnormal_pain_threshold | 1.64186302 |
| 32 | MP0005386_behavior/neurological_phenoty | 1.63801847 |
| 33 | MP0004924_abnormal_behavior | 1.63801847 |
| 34 | MP0002837_dystrophic_cardiac_calcinosis | 1.58837272 |
| 35 | MP0004885_abnormal_endolymph | 1.53461313 |
| 36 | MP0002184_abnormal_innervation | 1.53083431 |
| 37 | MP0002557_abnormal_social/conspecific_i | 1.51698785 |
| 38 | MP0003122_maternal_imprinting | 1.50387012 |
| 39 | MP0001905_abnormal_dopamine_level | 1.50353999 |
| 40 | MP0000955_abnormal_spinal_cord | 1.41235731 |
| 41 | MP0000751_myopathy | 1.41220197 |
| 42 | MP0000920_abnormal_myelination | 1.40911513 |
| 43 | MP0002066_abnormal_motor_capabilities/c | 1.38024578 |
| 44 | MP0003123_paternal_imprinting | 1.36353469 |
| 45 | MP0002882_abnormal_neuron_morphology | 1.34042079 |
| 46 | MP0003690_abnormal_glial_cell | 1.33251008 |
| 47 | MP0004811_abnormal_neuron_physiology | 1.32359666 |
| 48 | MP0003787_abnormal_imprinting | 1.32346166 |
| 49 | MP0005167_abnormal_blood-brain_barrier | 1.27813677 |
| 50 | MP0005551_abnormal_eye_electrophysiolog | 1.26478572 |
| 51 | MP0004145_abnormal_muscle_electrophysio | 1.25159534 |
| 52 | MP0003633_abnormal_nervous_system | 1.24479855 |
| 53 | MP0001502_abnormal_circadian_rhythm | 1.24356461 |
| 54 | MP0003879_abnormal_hair_cell | 1.23275328 |
| 55 | MP0005410_abnormal_fertilization | 1.23055815 |
| 56 | MP0003172_abnormal_lysosome_physiology | 1.22437615 |
| 57 | MP0002909_abnormal_adrenal_gland | 1.21314785 |
| 58 | MP0005645_abnormal_hypothalamus_physiol | 1.17510263 |
| 59 | MP0002229_neurodegeneration | 1.16769292 |
| 60 | MP0003631_nervous_system_phenotype | 1.15081279 |
| 61 | MP0004858_abnormal_nervous_system | 1.13382981 |
| 62 | MP0004043_abnormal_pH_regulation | 1.11541571 |
| 63 | MP0002876_abnormal_thyroid_physiology | 1.07583572 |
| 64 | MP0004742_abnormal_vestibular_system | 1.05212096 |
| 65 | MP0008877_abnormal_DNA_methylation | 1.02059683 |
| 66 | MP0003634_abnormal_glial_cell | 1.01841508 |
| 67 | MP0003632_abnormal_nervous_system | 0.98957332 |
| 68 | MP0001986_abnormal_taste_sensitivity | 0.98191442 |
| 69 | MP0004510_myositis | 0.97764891 |
| 70 | MP0002152_abnormal_brain_morphology | 0.96821422 |
| 71 | MP0004085_abnormal_heartbeat | 0.95782913 |
| 72 | MP0000013_abnormal_adipose_tissue | 0.95025220 |
| 73 | MP0008872_abnormal_physiological_respon | 0.94943344 |
| 74 | MP0003121_genomic_imprinting | 0.94733716 |
| 75 | MP0002638_abnormal_pupillary_reflex | 0.94639834 |
| 76 | MP0003075_altered_response_to | 0.94486341 |
| 77 | MP0004036_abnormal_muscle_relaxation | 0.94072855 |
| 78 | MP0004215_abnormal_myocardial_fiber | 0.93310928 |
| 79 | MP0001188_hyperpigmentation | 0.93141876 |
| 80 | MP0005535_abnormal_body_temperature | 0.92363829 |
| 81 | MP0002069_abnormal_eating/drinking_beha | 0.91503583 |
| 82 | MP0003137_abnormal_impulse_conducting | 0.89256797 |
| 83 | MP0002089_abnormal_postnatal_growth/wei | 0.86234734 |
| 84 | MP0000604_amyloidosis | 0.86144522 |
| 85 | MP0001963_abnormal_hearing_physiology | 0.86142217 |
| 86 | MP0005377_hearing/vestibular/ear_phenot | 0.85922930 |
| 87 | MP0003878_abnormal_ear_physiology | 0.85922930 |
| 88 | MP0002090_abnormal_vision | 0.84500692 |
| 89 | MP0001485_abnormal_pinna_reflex | 0.84088950 |
| 90 | MP0002752_abnormal_somatic_nervous | 0.83690757 |
| 91 | MP0008874_decreased_physiological_sensi | 0.83623372 |
| 92 | MP0003646_muscle_fatigue | 0.81424798 |
| 93 | MP0000566_synostosis | 0.79683802 |
| 94 | MP0008875_abnormal_xenobiotic_pharmacok | 0.79615957 |
| 95 | MP0006292_abnormal_olfactory_placode | 0.77253990 |
| 96 | MP0001177_atelectasis | 0.76575081 |
| 97 | MP0005171_absent_coat_pigmentation | 0.75912762 |
| 98 | MP0000631_abnormal_neuroendocrine_gland | 0.72676488 |
| 99 | MP0004130_abnormal_muscle_cell | 0.70869782 |
| 100 | MP0001346_abnormal_lacrimal_gland | 0.67036255 |
| 101 | MP0005499_abnormal_olfactory_system | 0.66815911 |
| 102 | MP0005394_taste/olfaction_phenotype | 0.66815911 |
| 103 | MP0000747_muscle_weakness | 0.66629914 |
| 104 | MP0001664_abnormal_digestion | 0.65561032 |
| 105 | MP0003283_abnormal_digestive_organ | 0.65054881 |
| 106 | MP0005085_abnormal_gallbladder_physiolo | 0.64564942 |
| 107 | MP0002139_abnormal_hepatobiliary_system | 0.63445811 |
| 108 | MP0003183_abnormal_peptide_metabolism | 0.62084306 |
| 109 | MP0000749_muscle_degeneration | 0.61394174 |
| 110 | MP0004484_altered_response_of | 0.61294060 |
| 111 | MP0005620_abnormal_muscle_contractility | 0.59181199 |
| 112 | MP0003195_calcinosis | 0.57804348 |
| 113 | MP0005360_urolithiasis | 0.57443801 |
| 114 | MP0002332_abnormal_exercise_endurance | 0.57232788 |
| 115 | MP0004233_abnormal_muscle_weight | 0.57095654 |
| 116 | MP0005409_darkened_coat_color | 0.56953270 |
| 117 | MP0002249_abnormal_larynx_morphology | 0.56784233 |
| 118 | MP0010769_abnormal_survival | 0.56714412 |
| 119 | MP0006035_abnormal_mitochondrial_morpho | 0.56707281 |
| 120 | MP0003698_abnormal_male_reproductive | 0.56222423 |
| 121 | MP0000026_abnormal_inner_ear | 0.56192740 |
| 122 | MP0005464_abnormal_platelet_physiology | 0.56008126 |
| 123 | MP0010768_mortality/aging | 0.53113885 |
| 124 | MP0005670_abnormal_white_adipose | 0.52734496 |
| 125 | MP0000639_abnormal_adrenal_gland | 0.52392286 |
| 126 | MP0003861_abnormal_nervous_system | 0.50779400 |
| 127 | MP0010770_preweaning_lethality | 0.50689268 |
| 128 | MP0002082_postnatal_lethality | 0.50689268 |
| 129 | MP0001348_abnormal_lacrimal_gland | 0.50680452 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 6.67970666 |
| 2 | Myokymia (HP:0002411) | 5.52187226 |
| 3 | Focal seizures (HP:0007359) | 4.54714969 |
| 4 | Atonic seizures (HP:0010819) | 4.52252713 |
| 5 | Epileptic encephalopathy (HP:0200134) | 4.36540801 |
| 6 | Hyperventilation (HP:0002883) | 4.10397074 |
| 7 | Febrile seizures (HP:0002373) | 3.84092477 |
| 8 | Visual hallucinations (HP:0002367) | 3.81110595 |
| 9 | Progressive cerebellar ataxia (HP:0002073) | 3.80264462 |
| 10 | Pheochromocytoma (HP:0002666) | 3.62986082 |
| 11 | Absence seizures (HP:0002121) | 3.49925048 |
| 12 | Annular pancreas (HP:0001734) | 3.39265977 |
| 13 | Generalized tonic-clonic seizures (HP:0002069) | 3.39002073 |
| 14 | Dialeptic seizures (HP:0011146) | 3.35989110 |
| 15 | Neuroendocrine neoplasm (HP:0100634) | 3.31609331 |
| 16 | Cerebral hypomyelination (HP:0006808) | 3.25810124 |
| 17 | Peripheral hypomyelination (HP:0007182) | 3.21043462 |
| 18 | Akinesia (HP:0002304) | 3.14031212 |
| 19 | Tetraplegia (HP:0002445) | 3.10720192 |
| 20 | Obstructive sleep apnea (HP:0002870) | 3.04973693 |
| 21 | Dysmetria (HP:0001310) | 3.02206516 |
| 22 | Mutism (HP:0002300) | 3.00921032 |
| 23 | Delusions (HP:0000746) | 2.99994982 |
| 24 | Neurofibrillary tangles (HP:0002185) | 2.99164967 |
| 25 | Action tremor (HP:0002345) | 2.96946374 |
| 26 | Dysdiadochokinesis (HP:0002075) | 2.93793648 |
| 27 | Scanning speech (HP:0002168) | 2.91553413 |
| 28 | Supranuclear gaze palsy (HP:0000605) | 2.89420238 |
| 29 | Broad-based gait (HP:0002136) | 2.88561418 |
| 30 | Abnormal eating behavior (HP:0100738) | 2.87270139 |
| 31 | Ankle clonus (HP:0011448) | 2.83279314 |
| 32 | Neuronal loss in central nervous system (HP:0002529) | 2.82622166 |
| 33 | Anxiety (HP:0000739) | 2.82067077 |
| 34 | Rigidity (HP:0002063) | 2.80188699 |
| 35 | Gaze-evoked nystagmus (HP:0000640) | 2.75469891 |
| 36 | Spastic gait (HP:0002064) | 2.65989898 |
| 37 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.65844091 |
| 38 | Sleep apnea (HP:0010535) | 2.60362346 |
| 39 | Cerebral inclusion bodies (HP:0100314) | 2.59438384 |
| 40 | Abnormality of the corticospinal tract (HP:0002492) | 2.53884948 |
| 41 | Papilledema (HP:0001085) | 2.52988188 |
| 42 | Depression (HP:0000716) | 2.52308706 |
| 43 | Poor eye contact (HP:0000817) | 2.51413464 |
| 44 | Intention tremor (HP:0002080) | 2.48916675 |
| 45 | Impaired social interactions (HP:0000735) | 2.46521120 |
| 46 | Abnormal social behavior (HP:0012433) | 2.46521120 |
| 47 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.45241798 |
| 48 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.45241798 |
| 49 | Termporal pattern (HP:0011008) | 2.45068952 |
| 50 | Insidious onset (HP:0003587) | 2.45068952 |
| 51 | Epileptiform EEG discharges (HP:0011182) | 2.43786520 |
| 52 | Limb dystonia (HP:0002451) | 2.42172776 |
| 53 | Truncal ataxia (HP:0002078) | 2.34238903 |
| 54 | Progressive inability to walk (HP:0002505) | 2.33819099 |
| 55 | EEG with generalized epileptiform discharges (HP:0011198) | 2.32334045 |
| 56 | Postural instability (HP:0002172) | 2.31927740 |
| 57 | Increased circulating renin level (HP:0000848) | 2.27781542 |
| 58 | Apathy (HP:0000741) | 2.26885467 |
| 59 | Status epilepticus (HP:0002133) | 2.26204190 |
| 60 | Sensory axonal neuropathy (HP:0003390) | 2.24358936 |
| 61 | Stereotypic behavior (HP:0000733) | 2.24033585 |
| 62 | Exercise-induced myalgia (HP:0003738) | 2.23784145 |
| 63 | Hypsarrhythmia (HP:0002521) | 2.23273035 |
| 64 | Excessive salivation (HP:0003781) | 2.23084820 |
| 65 | Drooling (HP:0002307) | 2.23084820 |
| 66 | Amblyopia (HP:0000646) | 2.22927273 |
| 67 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.22704217 |
| 68 | Torticollis (HP:0000473) | 2.22124300 |
| 69 | Rapidly progressive (HP:0003678) | 2.20280544 |
| 70 | Polyphagia (HP:0002591) | 2.19658877 |
| 71 | Choreoathetosis (HP:0001266) | 2.17513742 |
| 72 | Generalized myoclonic seizures (HP:0002123) | 2.16739749 |
| 73 | Gait imbalance (HP:0002141) | 2.15815962 |
| 74 | Impaired smooth pursuit (HP:0007772) | 2.15583244 |
| 75 | Diminished motivation (HP:0000745) | 2.14818308 |
| 76 | Thickened helices (HP:0000391) | 2.13815942 |
| 77 | Lower limb muscle weakness (HP:0007340) | 2.13552222 |
| 78 | Focal dystonia (HP:0004373) | 2.12985325 |
| 79 | Abnormality of saccadic eye movements (HP:0000570) | 2.12616480 |
| 80 | Megalencephaly (HP:0001355) | 2.10000913 |
| 81 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.08142750 |
| 82 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.05173951 |
| 83 | Blue irides (HP:0000635) | 2.05079319 |
| 84 | Increased serum pyruvate (HP:0003542) | 2.03646324 |
| 85 | Abnormality of glycolysis (HP:0004366) | 2.03646324 |
| 86 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.03193168 |
| 87 | Urinary urgency (HP:0000012) | 2.02532867 |
| 88 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.02232078 |
| 89 | Hemiparesis (HP:0001269) | 2.01714767 |
| 90 | Acute necrotizing encephalopathy (HP:0006965) | 2.01491185 |
| 91 | Bundle branch block (HP:0011710) | 1.99158152 |
| 92 | Spastic tetraparesis (HP:0001285) | 1.99096097 |
| 93 | Absent speech (HP:0001344) | 1.98057434 |
| 94 | Abnormality of the lower motor neuron (HP:0002366) | 1.96913571 |
| 95 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.96826048 |
| 96 | Insomnia (HP:0100785) | 1.96440497 |
| 97 | Diminished movement (HP:0002374) | 1.96222003 |
| 98 | CNS hypomyelination (HP:0003429) | 1.95176082 |
| 99 | Central scotoma (HP:0000603) | 1.94597617 |
| 100 | Craniofacial dystonia (HP:0012179) | 1.92893151 |
| 101 | Dementia (HP:0000726) | 1.92734620 |
| 102 | Inability to walk (HP:0002540) | 1.92718610 |
| 103 | Congenital primary aphakia (HP:0007707) | 1.92449397 |
| 104 | Nephrogenic diabetes insipidus (HP:0009806) | 1.90797122 |
| 105 | Impaired vibratory sensation (HP:0002495) | 1.90562396 |
| 106 | Bradykinesia (HP:0002067) | 1.90350964 |
| 107 | Specific learning disability (HP:0001328) | 1.89556446 |
| 108 | Poor suck (HP:0002033) | 1.87939208 |
| 109 | Fetal akinesia sequence (HP:0001989) | 1.87352066 |
| 110 | Cholecystitis (HP:0001082) | 1.84807673 |
| 111 | Abnormal gallbladder physiology (HP:0012438) | 1.84807673 |
| 112 | Diplopia (HP:0000651) | 1.83927994 |
| 113 | Abnormality of binocular vision (HP:0011514) | 1.83927994 |
| 114 | Medial flaring of the eyebrow (HP:0010747) | 1.83709880 |
| 115 | Psychosis (HP:0000709) | 1.83104914 |
| 116 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.81932306 |
| 117 | Ventricular fibrillation (HP:0001663) | 1.81119149 |
| 118 | Progressive macrocephaly (HP:0004481) | 1.80974454 |
| 119 | Acute encephalopathy (HP:0006846) | 1.80124112 |
| 120 | Slow saccadic eye movements (HP:0000514) | 1.79945339 |
| 121 | Hyperthyroidism (HP:0000836) | 1.79793207 |
| 122 | Gait ataxia (HP:0002066) | 1.79357912 |
| 123 | Failure to thrive in infancy (HP:0001531) | 1.79263346 |
| 124 | Incomplete penetrance (HP:0003829) | 1.79069376 |
| 125 | Spastic tetraplegia (HP:0002510) | 1.78121959 |
| 126 | Heart block (HP:0012722) | 1.77653216 |
| 127 | Hemiplegia (HP:0002301) | 1.77498551 |
| 128 | Split foot (HP:0001839) | 1.77223663 |
| 129 | Genetic anticipation (HP:0003743) | 1.75555636 |
| 130 | Cerebral hemorrhage (HP:0001342) | 1.74610584 |
| 131 | Vaginal atresia (HP:0000148) | 1.74361483 |
| 132 | Lower limb amyotrophy (HP:0007210) | 1.73158421 |
| 133 | Genital tract atresia (HP:0001827) | 1.72997371 |
| 134 | Clonus (HP:0002169) | 1.72387169 |
| 135 | Aplasia of the phalanges of the hand (HP:0009802) | 1.72038854 |
| 136 | Aplasia involving bones of the extremities (HP:0009825) | 1.72038854 |
| 137 | Iris hypopigmentation (HP:0007730) | 1.70587187 |
| 138 | Lower limb asymmetry (HP:0100559) | 1.69932461 |
| 139 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.67997133 |
| 140 | Spinal canal stenosis (HP:0003416) | 1.67821234 |
| 141 | Hypokinesia (HP:0002375) | 1.67438481 |
| 142 | Memory impairment (HP:0002354) | 1.67248659 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 3.88945062 |
| 2 | EPHA4 | 3.68112843 |
| 3 | CASK | 3.27977459 |
| 4 | MAP3K4 | 2.93149300 |
| 5 | MAP3K9 | 2.65132726 |
| 6 | PRPF4B | 2.54843915 |
| 7 | MAP2K7 | 2.41759410 |
| 8 | CDK19 | 2.17109937 |
| 9 | OXSR1 | 2.12644874 |
| 10 | DAPK2 | 2.11361817 |
| 11 | MARK1 | 2.06825218 |
| 12 | MINK1 | 2.04411983 |
| 13 | MAP2K4 | 2.03280778 |
| 14 | MAP3K11 | 1.85326384 |
| 15 | PAK6 | 1.85152224 |
| 16 | MAP3K12 | 1.82896521 |
| 17 | NTRK2 | 1.69788990 |
| 18 | STK39 | 1.61894517 |
| 19 | PLK2 | 1.56605508 |
| 20 | SGK494 | 1.54401784 |
| 21 | SGK223 | 1.54401784 |
| 22 | KSR2 | 1.52471418 |
| 23 | GRK5 | 1.49558529 |
| 24 | ARAF | 1.48020394 |
| 25 | PRKD3 | 1.41103609 |
| 26 | PHKG1 | 1.38578558 |
| 27 | PHKG2 | 1.38578558 |
| 28 | CDK5 | 1.36767741 |
| 29 | NTRK1 | 1.34279904 |
| 30 | TNIK | 1.33902435 |
| 31 | UHMK1 | 1.26895274 |
| 32 | CAMK2B | 1.24560953 |
| 33 | KSR1 | 1.22312344 |
| 34 | SIK2 | 1.21763657 |
| 35 | PRKCG | 1.20718416 |
| 36 | PINK1 | 1.19799189 |
| 37 | CAMK2A | 1.19648104 |
| 38 | RIPK1 | 1.17743426 |
| 39 | MAP3K13 | 1.17032967 |
| 40 | PNCK | 1.13161721 |
| 41 | MAPK13 | 1.08648989 |
| 42 | BCR | 1.06331153 |
| 43 | DAPK1 | 1.02101545 |
| 44 | SGK2 | 1.00625630 |
| 45 | CAMKK1 | 0.99745345 |
| 46 | AKT3 | 0.98917324 |
| 47 | LATS2 | 0.97898543 |
| 48 | WNK1 | 0.96874780 |
| 49 | CAMK2G | 0.94318957 |
| 50 | CAMK2D | 0.93660190 |
| 51 | STK38 | 0.92690990 |
| 52 | PKN1 | 0.90944118 |
| 53 | LMTK2 | 0.89749966 |
| 54 | PDK3 | 0.89600905 |
| 55 | PDK4 | 0.89600905 |
| 56 | PRKCH | 0.88094166 |
| 57 | PAK3 | 0.87946694 |
| 58 | NME1 | 0.86671196 |
| 59 | MAPK12 | 0.86201106 |
| 60 | CDK18 | 0.84654168 |
| 61 | FES | 0.83565815 |
| 62 | CDK14 | 0.82778786 |
| 63 | CDK15 | 0.82496464 |
| 64 | WNK4 | 0.82312680 |
| 65 | TESK1 | 0.82215770 |
| 66 | MUSK | 0.81704975 |
| 67 | PTK2B | 0.79924959 |
| 68 | PRKCE | 0.78748235 |
| 69 | NEK6 | 0.77191480 |
| 70 | SGK3 | 0.76052098 |
| 71 | RIPK4 | 0.74885961 |
| 72 | CAMK1 | 0.73458722 |
| 73 | BRSK1 | 0.72507905 |
| 74 | MAPK10 | 0.71828790 |
| 75 | TYRO3 | 0.71534259 |
| 76 | CSNK1G3 | 0.71446817 |
| 77 | CSNK1G2 | 0.71337119 |
| 78 | CDK11A | 0.70142654 |
| 79 | CAMK4 | 0.68834479 |
| 80 | MAPKAPK5 | 0.68210079 |
| 81 | ROCK2 | 0.67763521 |
| 82 | STK11 | 0.66463836 |
| 83 | BMX | 0.66263115 |
| 84 | ALK | 0.65350572 |
| 85 | PDPK1 | 0.64947107 |
| 86 | MAP3K2 | 0.64730178 |
| 87 | DYRK1A | 0.64394812 |
| 88 | SGK1 | 0.64369166 |
| 89 | BMPR2 | 0.60071156 |
| 90 | ADRBK2 | 0.59586471 |
| 91 | MARK2 | 0.59441216 |
| 92 | CAMKK2 | 0.58246698 |
| 93 | DYRK2 | 0.56817352 |
| 94 | FGFR2 | 0.56474026 |
| 95 | OBSCN | 0.56132452 |
| 96 | PDK2 | 0.54429693 |
| 97 | PDK1 | 0.54199729 |
| 98 | TNK2 | 0.54161123 |
| 99 | FER | 0.53805614 |
| 100 | ERBB4 | 0.53664221 |
| 101 | CCNB1 | 0.53642483 |
| 102 | WNK3 | 0.52957126 |
| 103 | RET | 0.52825838 |
| 104 | MAP3K1 | 0.51826236 |
| 105 | CAMK1G | 0.50277798 |
| 106 | BRAF | 0.50047209 |
| 107 | PRKCZ | 0.49817886 |
| 108 | TAOK2 | 0.48869901 |
| 109 | MAP3K7 | 0.48370807 |
| 110 | DYRK1B | 0.46871921 |
| 111 | DAPK3 | 0.46014713 |
| 112 | GRK7 | 0.46009967 |
| 113 | RPS6KA3 | 0.45560894 |
| 114 | PRKACA | 0.45067421 |
| 115 | CDC42BPA | 0.44562950 |
| 116 | INSRR | 0.44329193 |
| 117 | CSNK1G1 | 0.43481706 |
| 118 | IRAK2 | 0.42894782 |
| 119 | FYN | 0.38866144 |
| 120 | PRKG2 | 0.37882031 |
| 121 | LIMK1 | 0.37445452 |
| 122 | PRKCA | 0.29521570 |
| 123 | PRKG1 | 0.29441074 |
| 124 | MAP3K5 | 0.27567564 |
| 125 | CSNK1D | 0.27256644 |
| 126 | RPS6KA2 | 0.26074363 |
| 127 | CAMK1D | 0.24776194 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.34508236 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.14662813 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 2.57810789 |
| 4 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.37029573 |
| 5 | Olfactory transduction_Homo sapiens_hsa04740 | 2.25143811 |
| 6 | Circadian entrainment_Homo sapiens_hsa04713 | 2.18827261 |
| 7 | Morphine addiction_Homo sapiens_hsa05032 | 2.18672218 |
| 8 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.10675272 |
| 9 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.04243894 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.92906594 |
| 11 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.92711309 |
| 12 | Long-term potentiation_Homo sapiens_hsa04720 | 1.87702816 |
| 13 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.85849758 |
| 14 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.79174063 |
| 15 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.69263691 |
| 16 | Salivary secretion_Homo sapiens_hsa04970 | 1.65472735 |
| 17 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.63294798 |
| 18 | Insulin secretion_Homo sapiens_hsa04911 | 1.59801753 |
| 19 | Taste transduction_Homo sapiens_hsa04742 | 1.56463359 |
| 20 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.53076611 |
| 21 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.51995276 |
| 22 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.44818480 |
| 23 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.40632054 |
| 24 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.40185662 |
| 25 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.38517872 |
| 26 | Long-term depression_Homo sapiens_hsa04730 | 1.38202353 |
| 27 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.38152033 |
| 28 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.36733196 |
| 29 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.36661572 |
| 30 | Cocaine addiction_Homo sapiens_hsa05030 | 1.35989508 |
| 31 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.35953264 |
| 32 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.35116059 |
| 33 | Renin secretion_Homo sapiens_hsa04924 | 1.33958984 |
| 34 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.30323800 |
| 35 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.29499640 |
| 36 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.29285756 |
| 37 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.28895141 |
| 38 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.27068617 |
| 39 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.17003136 |
| 40 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.15925760 |
| 41 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.14792196 |
| 42 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.11419382 |
| 43 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.05998979 |
| 44 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.02607747 |
| 45 | Parkinsons disease_Homo sapiens_hsa05012 | 1.02535939 |
| 46 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.01594172 |
| 47 | Alzheimers disease_Homo sapiens_hsa05010 | 0.98379756 |
| 48 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.96680345 |
| 49 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.95347192 |
| 50 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.92829733 |
| 51 | Axon guidance_Homo sapiens_hsa04360 | 0.91645021 |
| 52 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.89870340 |
| 53 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.89475232 |
| 54 | Gap junction_Homo sapiens_hsa04540 | 0.89353491 |
| 55 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.88946828 |
| 56 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.88245614 |
| 57 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.88178691 |
| 58 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.85110499 |
| 59 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.83397878 |
| 60 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.83112022 |
| 61 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.82750425 |
| 62 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.82504871 |
| 63 | Phototransduction_Homo sapiens_hsa04744 | 0.80978429 |
| 64 | Bile secretion_Homo sapiens_hsa04976 | 0.80158359 |
| 65 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.79361285 |
| 66 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.79131963 |
| 67 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.78023763 |
| 68 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.77677950 |
| 69 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.76788744 |
| 70 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.76034121 |
| 71 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.75215908 |
| 72 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.74116719 |
| 73 | Melanogenesis_Homo sapiens_hsa04916 | 0.66636590 |
| 74 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.66035897 |
| 75 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.63584098 |
| 76 | Endocytosis_Homo sapiens_hsa04144 | 0.63538027 |
| 77 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.63369231 |
| 78 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.62838753 |
| 79 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.62369457 |
| 80 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.62216540 |
| 81 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.61691747 |
| 82 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.60953731 |
| 83 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.59318364 |
| 84 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.58776454 |
| 85 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.57177077 |
| 86 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.56483273 |
| 87 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.56060604 |
| 88 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.53536000 |
| 89 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.53306793 |
| 90 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.53228678 |
| 91 | Huntingtons disease_Homo sapiens_hsa05016 | 0.51461287 |
| 92 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.51089407 |
| 93 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.49204547 |
| 94 | Carbon metabolism_Homo sapiens_hsa01200 | 0.48577674 |
| 95 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.48374227 |
| 96 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.47024624 |
| 97 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.44280545 |
| 98 | Alcoholism_Homo sapiens_hsa05034 | 0.43732653 |
| 99 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.43635294 |
| 100 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.42769966 |
| 101 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.42630292 |
| 102 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.41180482 |
| 103 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.40589507 |
| 104 | Circadian rhythm_Homo sapiens_hsa04710 | 0.39945789 |
| 105 | Glioma_Homo sapiens_hsa05214 | 0.39539761 |
| 106 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.39270972 |
| 107 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.39245778 |
| 108 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.37939258 |
| 109 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.36328190 |
| 110 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.36008171 |
| 111 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.35210871 |
| 112 | Peroxisome_Homo sapiens_hsa04146 | 0.34750107 |
| 113 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.34726198 |
| 114 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.34667862 |
| 115 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.34561425 |
| 116 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.34338089 |
| 117 | Prion diseases_Homo sapiens_hsa05020 | 0.33986261 |
| 118 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.33450814 |
| 119 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.31424630 |
| 120 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.30056955 |
| 121 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.29258916 |
| 122 | Platelet activation_Homo sapiens_hsa04611 | 0.26880044 |
| 123 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.26183182 |
| 124 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.25033058 |
| 125 | Sulfur relay system_Homo sapiens_hsa04122 | 0.23768109 |
| 126 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.22927570 |

