CDIPT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.29822210
2COPI coating of Golgi vesicle (GO:0048205)5.29822210
3NADH metabolic process (GO:0006734)4.63801166
4regulation of early endosome to late endosome transport (GO:2000641)4.56573870
5folic acid transport (GO:0015884)4.55980809
6GDP-mannose metabolic process (GO:0019673)4.44687817
7regulation of translational termination (GO:0006449)4.44404729
8folic acid metabolic process (GO:0046655)4.34887833
9purine nucleobase biosynthetic process (GO:0009113)4.25230810
10galactose catabolic process (GO:0019388)4.01566949
11proteasome assembly (GO:0043248)3.94004176
12negative regulation of erythrocyte differentiation (GO:0045647)3.86194507
13GMP metabolic process (GO:0046037)3.76454701
14L-methionine salvage (GO:0071267)3.74483052
15L-methionine biosynthetic process (GO:0071265)3.74483052
16amino acid salvage (GO:0043102)3.74483052
17formation of translation preinitiation complex (GO:0001731)3.73498702
18autophagic vacuole assembly (GO:0000045)3.66529332
19nucleobase biosynthetic process (GO:0046112)3.59240272
20protein maturation by protein folding (GO:0022417)3.56536237
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.55401112
22L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.52645746
23neuromuscular process controlling posture (GO:0050884)3.52039927
24modified amino acid transport (GO:0072337)3.51491751
25protein localization to endosome (GO:0036010)3.50149275
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.49428648
27ribosome assembly (GO:0042255)3.46219876
28protein retention in ER lumen (GO:0006621)3.35679306
29sodium ion export (GO:0071436)3.34699006
30regulation of cellular amino acid metabolic process (GO:0006521)3.33722428
31vitamin transmembrane transport (GO:0035461)3.32881810
32DNA deamination (GO:0045006)3.28283733
33anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.25811707
34stress fiber assembly (GO:0043149)3.25687759
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25592209
36barbed-end actin filament capping (GO:0051016)3.24525594
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.22380386
38negative regulation of ligase activity (GO:0051352)3.21805830
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21805830
40retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.20484899
41negative regulation of microtubule polymerization (GO:0031115)3.18591871
42positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17105330
43negative regulation of glycoprotein biosynthetic process (GO:0010561)3.16092318
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.15378950
45regulation of short-term neuronal synaptic plasticity (GO:0048172)3.11385295
46* CDP-diacylglycerol metabolic process (GO:0046341)3.09993717
47CDP-diacylglycerol biosynthetic process (GO:0016024)3.09993717
48synaptic vesicle maturation (GO:0016188)3.08738162
49positive regulation of synapse maturation (GO:0090129)3.08173630
50positive regulation of ligase activity (GO:0051351)2.99340794
51chaperone mediated protein folding requiring cofactor (GO:0051085)2.98349842
52synaptic vesicle exocytosis (GO:0016079)2.97564760
53Arp2/3 complex-mediated actin nucleation (GO:0034314)2.96077229
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94376590
55nucleoside diphosphate biosynthetic process (GO:0009133)2.93866312
56basement membrane organization (GO:0071711)2.92452796
57antigen processing and presentation of endogenous antigen (GO:0019883)2.92068843
58regulation of translation in response to stress (GO:0043555)2.91403222
59lung-associated mesenchyme development (GO:0060484)2.89250461
60cellular metabolic compound salvage (GO:0043094)2.88403045
61purine nucleotide salvage (GO:0032261)2.88350330
62positive regulation of Cdc42 GTPase activity (GO:0043089)2.86746033
63negative regulation of cell size (GO:0045792)2.83964821
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.83336156
65regulation of defense response to virus by virus (GO:0050690)2.82420439
66apoptotic process involved in morphogenesis (GO:0060561)2.80116562
67regulation of mammary gland epithelial cell proliferation (GO:0033599)2.78481603
68labyrinthine layer development (GO:0060711)2.77404047
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.77287307
70cellular potassium ion homeostasis (GO:0030007)2.77122288
71activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.76380287
72positive regulation of receptor recycling (GO:0001921)2.75968722
73cell-cell junction maintenance (GO:0045217)2.75441585
74methionine biosynthetic process (GO:0009086)2.69559287
75regulation of ubiquitin-protein transferase activity (GO:0051438)2.68846579
76regulation of synaptic vesicle exocytosis (GO:2000300)2.68694621
77adhesion of symbiont to host cell (GO:0044650)2.67943864
78virion attachment to host cell (GO:0019062)2.67943864
79regulation of sodium ion transmembrane transporter activity (GO:2000649)2.67589615
80pantothenate metabolic process (GO:0015939)2.66843923
81adhesion of symbiont to host (GO:0044406)2.65601136
82methionine metabolic process (GO:0006555)2.65351793
83antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.65165263
84positive regulation of nuclease activity (GO:0032075)2.64107239
85nucleotide-sugar biosynthetic process (GO:0009226)2.63173228
86glutamate secretion (GO:0014047)2.61837098
87negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61413792
88protein targeting to plasma membrane (GO:0072661)2.60302911
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.60192302
90mannose metabolic process (GO:0006013)2.60005917
91tooth mineralization (GO:0034505)2.59644060
92modulation by symbiont of host cellular process (GO:0044068)2.59229893
93localization within membrane (GO:0051668)2.58865987
94guanosine-containing compound biosynthetic process (GO:1901070)2.58782555
95regulation of extracellular matrix disassembly (GO:0010715)2.58510085
96adherens junction assembly (GO:0034333)2.58058577
97cytoskeletal anchoring at plasma membrane (GO:0007016)2.56674045
98negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.56082271
99regulation of ligase activity (GO:0051340)2.56039838
100intestinal epithelial cell development (GO:0060576)2.55915280
101DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.54753634
102regulation of cellular amine metabolic process (GO:0033238)2.54690540
103ribosome biogenesis (GO:0042254)2.54490671
104vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54294238
105transferrin transport (GO:0033572)2.53608375
106protein insertion into membrane (GO:0051205)2.53305889
107regulation of leukocyte degranulation (GO:0043300)2.51937244
108nucleobase-containing small molecule interconversion (GO:0015949)2.50774606
109energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.50562650
110ATP hydrolysis coupled proton transport (GO:0015991)2.50562650
111establishment of protein localization to mitochondrion (GO:0072655)2.50256680
112modulation by virus of host process (GO:0019054)2.49881409
113regulation of synaptic vesicle transport (GO:1902803)2.49606849
114signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.49396144
115signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.49396144
116signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.49396144
117focal adhesion assembly (GO:0048041)2.49145988
118cell-substrate adherens junction assembly (GO:0007045)2.49145988
119signal transduction involved in DNA integrity checkpoint (GO:0072401)2.48471887
120signal transduction involved in DNA damage checkpoint (GO:0072422)2.48471887
121regulation of ARF protein signal transduction (GO:0032012)2.47958984
122negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.47694677
123positive regulation of autophagy (GO:0010508)2.45740550
124vitamin transport (GO:0051180)2.45586967
125ribonucleoprotein complex disassembly (GO:0032988)2.45564563
126signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.45474808
127intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.45474808
128receptor recycling (GO:0001881)2.45409005
129interferon-gamma secretion (GO:0072643)2.45399946
130antigen processing and presentation of exogenous peptide antigen (GO:0002478)2.45385302
131peptidyl-proline hydroxylation (GO:0019511)2.45377294
132pinocytosis (GO:0006907)2.45341040
133vesicle coating (GO:0006901)2.45186577
134negative regulation of cell killing (GO:0031342)2.44598862
135negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.44598862
136regulation of regulated secretory pathway (GO:1903305)2.44367894
137semaphorin-plexin signaling pathway (GO:0071526)2.42833358
138maternal placenta development (GO:0001893)2.41424669
139positive regulation of protein dephosphorylation (GO:0035307)2.38904717
140positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.37507472
141negative regulation of fatty acid transport (GO:2000192)2.37206841
142G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.35854653
143embryo implantation (GO:0007566)2.33152043
144positive regulation of triglyceride lipase activity (GO:0061365)2.32338184
145positive regulation of lipoprotein lipase activity (GO:0051006)2.32338184
146cerebellar granule cell differentiation (GO:0021707)2.32241420
147modulation by virus of host morphology or physiology (GO:0019048)2.31258756
148regulation of myeloid leukocyte mediated immunity (GO:0002886)2.30760634
149ribosomal small subunit biogenesis (GO:0042274)2.30327736
150dopamine receptor signaling pathway (GO:0007212)2.29391812
151positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.25853577
152activation of MAPKKK activity (GO:0000185)2.25710747
153response to laminar fluid shear stress (GO:0034616)2.25348757
154cell-substrate junction assembly (GO:0007044)2.24978201
155planar cell polarity pathway involved in neural tube closure (GO:0090179)2.24738058
156endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.23373889
157pentose-phosphate shunt (GO:0006098)2.22351027
158positive regulation by symbiont of host defense response (GO:0052509)2.22204365
159modulation by symbiont of host defense response (GO:0052031)2.22204365
160modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.22204365
161modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.22204365
162positive regulation by organism of defense response of other organism involved in symbiotic interact2.22204365
163modulation by symbiont of host immune response (GO:0052553)2.22204365
164synaptic vesicle docking involved in exocytosis (GO:0016081)2.21209044
165regulation of T-helper 2 cell differentiation (GO:0045628)2.18950041
166positive regulation of blood vessel endothelial cell migration (GO:0043536)2.18792779
167hyaluronan catabolic process (GO:0030214)2.18393350
168protein carboxylation (GO:0018214)2.17822628
169peptidyl-glutamic acid carboxylation (GO:0017187)2.17822628
170response to acidic pH (GO:0010447)2.16879095
171glucose 6-phosphate metabolic process (GO:0051156)2.15500914
172regulation of mast cell degranulation (GO:0043304)2.15086579
173peptidyl-tyrosine autophosphorylation (GO:0038083)2.15030616
174regulation of ARF GTPase activity (GO:0032312)2.13875967
175regulation of necrotic cell death (GO:0010939)2.13425389
176skin morphogenesis (GO:0043589)2.11629229
177response to parathyroid hormone (GO:0071107)2.11367120
178vascular endothelial growth factor signaling pathway (GO:0038084)2.11061387
179regulation of glucocorticoid metabolic process (GO:0031943)2.10185823
180UV protection (GO:0009650)2.09274727
181virion assembly (GO:0019068)2.08925816
182negative regulation of homotypic cell-cell adhesion (GO:0034111)2.08392163
183positive regulation of regulated secretory pathway (GO:1903307)2.07404189
184regulation of glucose import in response to insulin stimulus (GO:2001273)2.07270333

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70839261
2ZNF263_19887448_ChIP-Seq_K562_Human2.92962325
3ETS1_20019798_ChIP-Seq_JURKAT_Human2.92558536
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87818251
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84753156
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.49249157
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.48444236
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28924740
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28458512
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08610572
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.04970542
12* MYC_18555785_ChIP-Seq_MESCs_Mouse2.04389310
13GABP_19822575_ChIP-Seq_HepG2_Human2.02922172
14KDM2B_26808549_Chip-Seq_K562_Human2.02504422
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01314781
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97746439
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95753601
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89108362
19ELK3_25401928_ChIP-Seq_HUVEC_Human1.87313036
20SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.85745395
21MYC_22102868_ChIP-Seq_BL_Human1.84232994
22TCF7_22412390_ChIP-Seq_EML_Mouse1.83810641
23LXR_22292898_ChIP-Seq_THP-1_Human1.82818539
24SRY_22984422_ChIP-ChIP_TESTIS_Rat1.81281773
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.77413714
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75819182
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74598894
28ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.73127395
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67822320
30* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65297984
31* XRN2_22483619_ChIP-Seq_HELA_Human1.63385996
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.63245515
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.62049518
34RACK7_27058665_Chip-Seq_MCF-7_Human1.60833300
35ATF3_27146783_Chip-Seq_COLON_Human1.60085777
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.59628374
37* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58638808
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57589393
39* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.57100064
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50748965
41KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49107762
42DCP1A_22483619_ChIP-Seq_HELA_Human1.46989018
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46722000
44NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46153031
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45851143
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45359871
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.45204472
48VDR_24763502_ChIP-Seq_THP-1_Human1.44009510
49* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43899391
50SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43126494
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.42716833
52KDM2B_26808549_Chip-Seq_JURKAT_Human1.42553583
53P68_20966046_ChIP-Seq_HELA_Human1.41511365
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.41250715
55* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40957179
56* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39848608
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39753136
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37591633
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35974674
60* VDR_23849224_ChIP-Seq_CD4+_Human1.35032440
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35001885
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.34898626
63* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.34794217
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.34526990
65CTCF_27219007_Chip-Seq_Bcells_Human1.33335682
66* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31917338
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.31733792
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30922902
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30308905
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29149605
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28885478
72BCOR_27268052_Chip-Seq_Bcells_Human1.27542791
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26364455
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26109471
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.25435694
76* FOXP1_21924763_ChIP-Seq_HESCs_Human1.24755119
77* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24282381
78CLOCK_20551151_ChIP-Seq_293T_Human1.23917212
79KDM2B_26808549_Chip-Seq_DND41_Human1.23386965
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22970591
81VDR_21846776_ChIP-Seq_THP-1_Human1.22742356
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.22169369
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21696834
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21506191
85* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20693851
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20280732
87SMC4_20622854_ChIP-Seq_HELA_Human1.20045073
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19517830
89BCL6_27268052_Chip-Seq_Bcells_Human1.19405753
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19389395
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19342231
92PHF8_20622854_ChIP-Seq_HELA_Human1.19139202
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18836274
94NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18395034
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18325710
96CIITA_25753668_ChIP-Seq_RAJI_Human1.18119078
97* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18117703
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17952034
99RUNX1_22412390_ChIP-Seq_EML_Mouse1.16520712
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16460383
101MAF_26560356_Chip-Seq_TH2_Human1.16429744
102TP53_22127205_ChIP-Seq_IMR90_Human1.15771182
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15110774
104TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.15023431
105KDM5A_27292631_Chip-Seq_BREAST_Human1.14818831
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14343418
107TFEB_21752829_ChIP-Seq_HELA_Human1.14154910
108UTX_26944678_Chip-Seq_JUKART_Human1.14026535
109MAF_26560356_Chip-Seq_TH1_Human1.13956517
110RXR_22158963_ChIP-Seq_LIVER_Mouse1.13854120
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12954854
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12442467
113SA1_27219007_Chip-Seq_Bcells_Human1.12262357
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.12208524
115GATA1_19941827_ChIP-Seq_MEL_Mouse1.11468914
116GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10649334
117TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10475374
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10337509
119STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10199717
120* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10067427
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09586331
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09524192
123IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09254358
124MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08975859
125TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08718970
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08459230
127NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08212797
128PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07760948
129CREB1_26743006_Chip-Seq_LNCaP_Human1.07068257
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06978860
131SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06247892
132BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06200038
133CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05869547
134* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05451655
135* CTCF_26484167_Chip-Seq_Bcells_Mouse1.04925824
136HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04885792
137PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04786452
138EGR1_19374776_ChIP-ChIP_THP-1_Human1.04739665
139* TET1_21490601_ChIP-Seq_MESCs_Mouse1.04310771
140CTCF_21964334_Chip-Seq_Bcells_Human1.04261517
141RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04167984
142TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03708328
143CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03327123
144ERG_21242973_ChIP-ChIP_JURKAT_Human1.02903886
145SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02859405
146POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02576256
147SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02469150
148* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00098399
149TP63_22573176_ChIP-Seq_HFKS_Human0.99141874
150CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98093018
151SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97953118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell5.50509743
2MP0003329_amyloid_beta_deposits3.91196236
3MP0008438_abnormal_cutaneous_collagen3.72341401
4MP0005058_abnormal_lysosome_morphology3.39132127
5MP0004859_abnormal_synaptic_plasticity3.36155539
6MP0003693_abnormal_embryo_hatching3.20578426
7MP0008260_abnormal_autophagy3.00984781
8MP0004858_abnormal_nervous_system2.67964621
9MP0000013_abnormal_adipose_tissue2.55603488
10MP0005451_abnormal_body_composition2.40217430
11MP0000604_amyloidosis2.40178729
12MP0004270_analgesia2.36132496
13MP0004510_myositis2.30624138
14MP0002909_abnormal_adrenal_gland2.20422009
15MP0003172_abnormal_lysosome_physiology2.18918984
16MP0001849_ear_inflammation2.15309445
17MP0002735_abnormal_chemical_nociception2.12659948
18MP0001968_abnormal_touch/_nociception2.03484301
19MP0003436_decreased_susceptibility_to2.00485547
20MP0003879_abnormal_hair_cell1.94630457
21MP0009278_abnormal_bone_marrow1.85683299
22MP0009379_abnormal_foot_pigmentation1.85124436
23MP0000747_muscle_weakness1.84317721
24MP0002736_abnormal_nociception_after1.83342335
25MP0002733_abnormal_thermal_nociception1.82725806
26MP0004957_abnormal_blastocyst_morpholog1.75960413
27MP0005503_abnormal_tendon_morphology1.74350272
28MP0000678_abnormal_parathyroid_gland1.71455743
29MP0001756_abnormal_urination1.69277549
30MP0002734_abnormal_mechanical_nocicepti1.68133447
31MP0000358_abnormal_cell_content/1.67811796
32MP0003635_abnormal_synaptic_transmissio1.66130574
33MP0009333_abnormal_splenocyte_physiolog1.65536718
34MP0001970_abnormal_pain_threshold1.60535420
35MP0001348_abnormal_lacrimal_gland1.60379917
36MP0004185_abnormal_adipocyte_glucose1.53422028
37MP0003866_abnormal_defecation1.52388736
38MP0005409_darkened_coat_color1.51364260
39MP0005275_abnormal_skin_tensile1.49396420
40MP0005257_abnormal_intraocular_pressure1.48038684
41MP0003300_gastrointestinal_ulcer1.45695257
42MP0002796_impaired_skin_barrier1.43334611
43MP0003191_abnormal_cellular_cholesterol1.41405328
44MP0001542_abnormal_bone_strength1.41359924
45MP0000858_altered_metastatic_potential1.39535331
46MP0003718_maternal_effect1.37168537
47MP0005083_abnormal_biliary_tract1.34334977
48MP0002064_seizures1.31325727
49MP0002998_abnormal_bone_remodeling1.30079020
50MP0001533_abnormal_skeleton_physiology1.29351457
51MP0010234_abnormal_vibrissa_follicle1.29076736
52MP0005423_abnormal_somatic_nervous1.27687291
53MP0005332_abnormal_amino_acid1.24978633
54MP0000751_myopathy1.24509114
55MP0005666_abnormal_adipose_tissue1.24093521
56MP0002249_abnormal_larynx_morphology1.23675046
57MP0004272_abnormal_basement_membrane1.22371811
58MP0003091_abnormal_cell_migration1.21996620
59MP0004084_abnormal_cardiac_muscle1.21758556
60MP0001730_embryonic_growth_arrest1.21273193
61MP0003724_increased_susceptibility_to1.20773216
62MP0008004_abnormal_stomach_pH1.20451014
63MP0000681_abnormal_thyroid_gland1.20387490
64MP0005375_adipose_tissue_phenotype1.19778669
65MP0009384_cardiac_valve_regurgitation1.19674725
66MP0009643_abnormal_urine_homeostasis1.17819573
67MP0003303_peritoneal_inflammation1.16996616
68MP0003453_abnormal_keratinocyte_physiol1.16408779
69MP0008874_decreased_physiological_sensi1.14127978
70MP0000003_abnormal_adipose_tissue1.12404991
71MP0003656_abnormal_erythrocyte_physiolo1.12226151
72MP0002269_muscular_atrophy1.11520769
73MP0010368_abnormal_lymphatic_system1.11266033
74MP0005623_abnormal_meninges_morphology1.10084989
75MP0005390_skeleton_phenotype1.08829082
76MP0002419_abnormal_innate_immunity1.08510653
77MP0002877_abnormal_melanocyte_morpholog1.06933254
78MP0005167_abnormal_blood-brain_barrier1.04662188
79MP0001958_emphysema1.03368774
80MP0000767_abnormal_smooth_muscle1.02388946
81MP0005508_abnormal_skeleton_morphology1.00526258
82MP0002653_abnormal_ependyma_morphology1.00124796
83MP0003705_abnormal_hypodermis_morpholog0.99736561
84MP0001440_abnormal_grooming_behavior0.99634160
85MP0005076_abnormal_cell_differentiation0.99239700
86MP0003221_abnormal_cardiomyocyte_apopto0.99033944
87MP0002060_abnormal_skin_morphology0.98583097
88MP0005501_abnormal_skin_physiology0.98292890
89MP0005025_abnormal_response_to0.97040048
90MP0010352_gastrointestinal_tract_polyps0.96717458
91MP0004811_abnormal_neuron_physiology0.96656690
92MP0003123_paternal_imprinting0.96553421
93MP0000343_altered_response_to0.95536730
94MP0006035_abnormal_mitochondrial_morpho0.95235669
95MP0001666_abnormal_nutrient_absorption0.95215770
96MP0005084_abnormal_gallbladder_morpholo0.94303451
97MP0002089_abnormal_postnatal_growth/wei0.93726793
98MP0001765_abnormal_ion_homeostasis0.93284893
99MP0002063_abnormal_learning/memory/cond0.93272372
100MP0006036_abnormal_mitochondrial_physio0.92972666
101MP0000462_abnormal_digestive_system0.92705144
102MP0001501_abnormal_sleep_pattern0.91897199
103MP0003111_abnormal_nucleus_morphology0.89022645
104MP0000920_abnormal_myelination0.87550073
105MP0000750_abnormal_muscle_regeneration0.86667363
106MP0001986_abnormal_taste_sensitivity0.86488698
107MP0003690_abnormal_glial_cell0.85473467
108MP0004043_abnormal_pH_regulation0.84474415
109MP0005166_decreased_susceptibility_to0.84433641
110MP0003566_abnormal_cell_adhesion0.82704409
111MP0005670_abnormal_white_adipose0.81239095
112MP0009745_abnormal_behavioral_response0.81192188
113MP0003828_pulmonary_edema0.80056090
114MP0005330_cardiomyopathy0.79720712
115MP0005310_abnormal_salivary_gland0.79315545
116MP0000465_gastrointestinal_hemorrhage0.79150725
117MP0004130_abnormal_muscle_cell0.78268184
118MP0002693_abnormal_pancreas_physiology0.77781051
119MP0003283_abnormal_digestive_organ0.77756907
120MP0005636_abnormal_mineral_homeostasis0.76403180
121MP0005621_abnormal_cell_physiology0.75700298
122MP0003634_abnormal_glial_cell0.75644283
123MP0000685_abnormal_immune_system0.75277535
124MP0002080_prenatal_lethality0.75131720
125MP0001944_abnormal_pancreas_morphology0.75032994
126MP0002272_abnormal_nervous_system0.74996981
127MP0009046_muscle_twitch0.74756593
128MP0004381_abnormal_hair_follicle0.74148126
129MP0008569_lethality_at_weaning0.73448401
130MP0005671_abnormal_response_to0.73312884
131MP0001661_extended_life_span0.72730946
132MP0002132_abnormal_respiratory_system0.72709522
133MP0005360_urolithiasis0.72204380
134MP0002933_joint_inflammation0.71689651
135MP0005464_abnormal_platelet_physiology0.70725958
136MP0006082_CNS_inflammation0.70261266
137MP0003806_abnormal_nucleotide_metabolis0.69991461
138MP0002295_abnormal_pulmonary_circulatio0.69903636
139MP0005384_cellular_phenotype0.69529553
140MP0008961_abnormal_basal_metabolism0.69407956
141MP0005000_abnormal_immune_tolerance0.68536387
142MP0004019_abnormal_vitamin_homeostasis0.68446691
143MP0003638_abnormal_response/metabolism_0.68180243
144MP0001905_abnormal_dopamine_level0.66944841
145MP0003183_abnormal_peptide_metabolism0.66673814
146MP0002896_abnormal_bone_mineralization0.65768910
147MP0003878_abnormal_ear_physiology0.65514614
148MP0005377_hearing/vestibular/ear_phenot0.65514614
149MP0003075_altered_response_to0.65286464
150MP0005023_abnormal_wound_healing0.65151226
151MP0003795_abnormal_bone_structure0.64779646
152MP0003448_altered_tumor_morphology0.64701320
153MP0004947_skin_inflammation0.64033471
154MP0010155_abnormal_intestine_physiology0.63763637
155MP0001851_eye_inflammation0.63322900
156MP0009780_abnormal_chondrocyte_physiolo0.63304422
157MP0000534_abnormal_ureter_morphology0.63303581
158MP0005319_abnormal_enzyme/_coenzyme0.62907137
159MP0000490_abnormal_crypts_of0.62446371
160MP0005395_other_phenotype0.62260062
161MP0005165_increased_susceptibility_to0.62218711
162MP0000759_abnormal_skeletal_muscle0.61915354
163MP0009931_abnormal_skin_appearance0.61579093
164MP0003279_aneurysm0.61367438
165MP0005595_abnormal_vascular_smooth0.61233815
166MP0004233_abnormal_muscle_weight0.60959326
167MP0002837_dystrophic_cardiac_calcinosis0.60445539
168MP0002136_abnormal_kidney_physiology0.59382073
169MP0002067_abnormal_sensory_capabilities0.58937515
170MP0004036_abnormal_muscle_relaxation0.58418921

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.16640559
2Gout (HP:0001997)3.83423988
3Cerebral hypomyelination (HP:0006808)3.69622804
4Visual hallucinations (HP:0002367)3.37815958
5Delusions (HP:0000746)3.36789776
6Dysautonomia (HP:0002459)3.30026981
7Ventricular fibrillation (HP:0001663)3.20915056
8Bundle branch block (HP:0011710)3.14004041
9Progressive muscle weakness (HP:0003323)3.02690957
10Microretrognathia (HP:0000308)2.94269178
11Increased cerebral lipofuscin (HP:0011813)2.94055975
12Myokymia (HP:0002411)2.91155667
13Difficulty climbing stairs (HP:0003551)2.89373813
14Abnormality of liposaccharide metabolism (HP:0010968)2.87642687
15Abnormality of glycosphingolipid metabolism (HP:0004343)2.87642687
16Abnormality of glycolipid metabolism (HP:0010969)2.87642687
17Obstructive sleep apnea (HP:0002870)2.79212499
18Increased variability in muscle fiber diameter (HP:0003557)2.74584109
19Polycythemia (HP:0001901)2.73510124
20Dysostosis multiplex (HP:0000943)2.71695710
21Myopathic facies (HP:0002058)2.68319947
22Postnatal microcephaly (HP:0005484)2.65559793
23Athetosis (HP:0002305)2.64981922
24Global brain atrophy (HP:0002283)2.64009939
25Eczematoid dermatitis (HP:0000976)2.63321507
26Mutism (HP:0002300)2.57062526
27Cerebral inclusion bodies (HP:0100314)2.55693523
28Premature rupture of membranes (HP:0001788)2.54070252
29Neurofibrillary tangles (HP:0002185)2.52942620
30Ankle contracture (HP:0006466)2.51511463
31Abnormality of the umbilical cord (HP:0010881)2.50534156
32CNS hypomyelination (HP:0003429)2.49645379
33Tetraplegia (HP:0002445)2.49578383
34Death in infancy (HP:0001522)2.49330433
35Personality changes (HP:0000751)2.47998100
36Hand muscle atrophy (HP:0009130)2.47992575
37Cervical subluxation (HP:0003308)2.44857407
38Atrophy/Degeneration involving motor neurons (HP:0007373)2.44396198
39Short nail (HP:0001799)2.39144957
40Abnormality of skeletal muscle fiber size (HP:0012084)2.39132078
41Systemic lupus erythematosus (HP:0002725)2.36060297
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.34601155
43Emotional lability (HP:0000712)2.33655325
44Multiple enchondromatosis (HP:0005701)2.32376123
45Ankle clonus (HP:0011448)2.30325550
46Fragile skin (HP:0001030)2.28792372
47Diminished motivation (HP:0000745)2.28740039
48Increased connective tissue (HP:0009025)2.27892076
49Abnormality of the distal phalanges of the toes (HP:0010182)2.27411605
50Distal upper limb amyotrophy (HP:0007149)2.26976539
51Upper limb amyotrophy (HP:0009129)2.26976539
52Peritonitis (HP:0002586)2.26094068
53Atrioventricular block (HP:0001678)2.25299995
54Restlessness (HP:0000711)2.25027502
55Supranuclear gaze palsy (HP:0000605)2.24607321
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24309584
57Abnormality of alanine metabolism (HP:0010916)2.24309584
58Hyperalaninemia (HP:0003348)2.24309584
59Blue sclerae (HP:0000592)2.23358772
60Abnormal neuron morphology (HP:0012757)2.21932805
61Abnormality of the motor neurons (HP:0002450)2.21932805
62Rough bone trabeculation (HP:0100670)2.20632621
63Apathy (HP:0000741)2.20325877
64Distal lower limb muscle weakness (HP:0009053)2.19485860
65Unsteady gait (HP:0002317)2.18319877
66Hyperacusis (HP:0010780)2.17549086
67Thin bony cortex (HP:0002753)2.17479004
68Vacuolated lymphocytes (HP:0001922)2.17101997
69Degeneration of anterior horn cells (HP:0002398)2.16833131
70Abnormality of the anterior horn cell (HP:0006802)2.16833131
71Breast hypoplasia (HP:0003187)2.16830831
72Genu recurvatum (HP:0002816)2.16384936
73Patent foramen ovale (HP:0001655)2.15446908
74Purpura (HP:0000979)2.14964873
75Cellulitis (HP:0100658)2.14909285
76Hyperglycinemia (HP:0002154)2.14350844
77Pustule (HP:0200039)2.13484812
78Abnormality of macrophages (HP:0004311)2.13240177
79Joint stiffness (HP:0001387)2.13005477
80Amyotrophic lateral sclerosis (HP:0007354)2.12764013
81Axonal loss (HP:0003447)2.12674233
82J-shaped sella turcica (HP:0002680)2.11845950
83Mitral regurgitation (HP:0001653)2.11022146
84Neuroendocrine neoplasm (HP:0100634)2.10360562
85Ulnar bowing (HP:0003031)2.09911507
86Generalized amyotrophy (HP:0003700)2.07841220
87Deep venous thrombosis (HP:0002625)2.07652028
88Pheochromocytoma (HP:0002666)2.07623509
89Shallow orbits (HP:0000586)2.07195114
90Interstitial pulmonary disease (HP:0006530)2.06259047
91Impaired pain sensation (HP:0007328)2.06211164
92Abnormality of pain sensation (HP:0010832)2.06211164
93Broad metatarsal (HP:0001783)2.04320229
94Dilatation of the ascending aorta (HP:0005111)2.03150522
95Glucose intolerance (HP:0000833)2.02583071
96CNS demyelination (HP:0007305)2.02375432
97Disproportionate tall stature (HP:0001519)2.01939241
98Spinal rigidity (HP:0003306)2.01150494
99Ileus (HP:0002595)2.01118794
100Centrally nucleated skeletal muscle fibers (HP:0003687)1.99945606
101Abnormality of the hip-girdle musculature (HP:0001445)1.99706058
102Abnormality of the musculature of the pelvis (HP:0001469)1.99706058
103Megaloblastic anemia (HP:0001889)1.99655141
104Mucopolysacchariduria (HP:0008155)1.99317003
105Urinary glycosaminoglycan excretion (HP:0003541)1.99317003
106Emphysema (HP:0002097)1.98893144
107Carpal bone hypoplasia (HP:0001498)1.98519850
108Hemorrhage of the eye (HP:0011885)1.97358334
109Distal lower limb amyotrophy (HP:0008944)1.96878589
110Aortic aneurysm (HP:0004942)1.96578345
111Spastic paraparesis (HP:0002313)1.95804013
112Vascular tortuosity (HP:0004948)1.94269573
113Asymmetric septal hypertrophy (HP:0001670)1.93815843
114Long palpebral fissure (HP:0000637)1.93813315
115Abnormal autonomic nervous system physiology (HP:0012332)1.93709132
116Bladder diverticulum (HP:0000015)1.93366165
117Rapidly progressive (HP:0003678)1.93025701
118Gastrointestinal dysmotility (HP:0002579)1.92195544
119Wormian bones (HP:0002645)1.91430502
120Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90698693
121Achilles tendon contracture (HP:0001771)1.89819403
122Hypercortisolism (HP:0001578)1.88806728
123Turricephaly (HP:0000262)1.88182729
124Biconcave vertebral bodies (HP:0004586)1.87964969
125Aneurysm (HP:0002617)1.87887803
126Atrophic scars (HP:0001075)1.86939878
127Cerebral aneurysm (HP:0004944)1.85240908
128Hyperglycinuria (HP:0003108)1.84998563
129Annular pancreas (HP:0001734)1.84051189
130Neuronal loss in central nervous system (HP:0002529)1.83204770
131Entropion (HP:0000621)1.82590921
132Abnormality of complement system (HP:0005339)1.81326954
133Segmental peripheral demyelination/remyelination (HP:0003481)1.80931554
134Vertebral compression fractures (HP:0002953)1.80205214
135Stridor (HP:0010307)1.79667558
136Trismus (HP:0000211)1.79567608
137Abnormality of polysaccharide metabolism (HP:0011012)1.79429604
138Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79429604
139Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79429604
140Gingivitis (HP:0000230)1.79068947
141Amyloidosis (HP:0011034)1.78871480
142Recurrent abscess formation (HP:0002722)1.78867871
143Polygenic inheritance (HP:0010982)1.78820152
144Abnormality of the nasal mucosa (HP:0000433)1.76391990
145Progressive neurologic deterioration (HP:0002344)1.75609497
146Slender build (HP:0001533)1.75223923
147Muscle fiber splitting (HP:0003555)1.74306056
148Limb-girdle muscle atrophy (HP:0003797)1.73625033
149Hyperextensible skin (HP:0000974)1.73144370
150Hyperparathyroidism (HP:0000843)1.71959405
151Hypertriglyceridemia (HP:0002155)1.71403044
152Heart block (HP:0012722)1.70946526
153Abnormality of the Achilles tendon (HP:0005109)1.70570363
154Ragged-red muscle fibers (HP:0003200)1.70273704
155Abnormal atrioventricular conduction (HP:0005150)1.70063409
156Insomnia (HP:0100785)1.69784143
157Mitral stenosis (HP:0001718)1.69717134
158Growth hormone excess (HP:0000845)1.69511124
159Brushfield spots (HP:0001088)1.69393291
160Loss of speech (HP:0002371)1.69317567
161Torticollis (HP:0000473)1.68049799
162Mildly elevated creatine phosphokinase (HP:0008180)1.67918758
163Fatigue (HP:0012378)1.67639117
164Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67260272
165Hypercalcemia (HP:0003072)1.66856746
166Spinal cord lesions (HP:0100561)1.66658695
167Syringomyelia (HP:0003396)1.66658695
168Premature skin wrinkling (HP:0100678)1.65157387
169Arterial tortuosity (HP:0005116)1.63336747
170Abnormality of the thoracic spine (HP:0100711)1.62847415

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.34364255
2ARAF3.70642473
3EPHA23.37789679
4MAP3K93.32818051
5TRIB33.09842844
6KSR22.93341811
7TESK22.89013642
8SIK12.74931093
9PRPF4B2.72104999
10SMG12.46681458
11ERN12.15255735
12KDR2.14223546
13MAP3K112.09979170
14TSSK62.07626237
15NME22.05872618
16RIPK12.02977277
17CAMKK21.93751558
18SCYL21.93099316
19ICK1.81753112
20NTRK11.78163228
21TAOK11.72153757
22TESK11.70403845
23PIM21.68357120
24ZAP701.60558904
25WEE11.56116200
26MARK21.50688201
27MAP3K21.50457960
28PRKD21.49831999
29CAMKK11.47605241
30MAP2K21.46593312
31BRAF1.46492259
32LIMK11.34157221
33PAK61.32972014
34MAP3K121.32614889
35MINK11.32456782
36NEK11.31468980
37LATS21.31082622
38NME11.29691869
39TTN1.27581445
40IRAK31.26721363
41MAP4K11.26431862
42RAF11.24121691
43BRSK11.23533924
44EIF2AK11.21680326
45PKN21.21441969
46EPHB11.15847110
47RPS6KA21.13899876
48STK161.13665620
49AKT31.11500868
50MAP3K11.07994201
51TYK21.07563684
52NTRK31.04641535
53EEF2K1.03570874
54PDGFRA1.02691165
55MAP2K11.02608361
56ALK1.01047820
57TBK11.00432666
58PRKCI1.00040830
59DYRK1B0.98377373
60FES0.97129994
61PTK20.94723792
62LRRK20.90931495
63PAK40.90792836
64BCKDK0.90326429
65MAP3K80.88343184
66BRSK20.87980034
67RIPK40.87021996
68TNK20.86175190
69BMX0.84520961
70CDC42BPA0.84126410
71DAPK10.84042113
72PDPK10.83299370
73MAP3K130.82668974
74RPS6KA40.81426757
75FGFR40.81165225
76RPS6KC10.79961778
77RPS6KL10.79961778
78PRKD30.79528969
79DDR20.79498413
80MAP3K60.77523547
81MAPKAPK30.77466254
82ABL20.76770995
83IRAK40.76292872
84RET0.76190912
85GRK60.76016847
86DAPK20.75708732
87EPHB20.74883783
88IRAK20.73933757
89PAK10.73739193
90NEK20.72867458
91CSK0.72587190
92MAPK120.71651637
93PAK30.71508758
94LMTK20.69020251
95CDK140.68904222
96GRK50.68139538
97TYRO30.67431807
98AURKA0.66335154
99PDK30.65035878
100PDK40.65035878
101MTOR0.64181514
102DAPK30.64048726
103PDK10.63347457
104MAP3K30.63211610
105KSR10.63018284
106CDK190.61495693
107HIPK20.60878584
108EIF2AK30.59100702
109RPS6KA60.56900674
110TGFBR20.56742940
111MYLK0.55944319
112PNCK0.54807785
113PINK10.54409873
114MAP3K50.53881301
115DMPK0.52794021
116FER0.52202138
117MOS0.50866504
118PRKCG0.50009358
119MARK10.48604361
120PRKD10.48447213
121CDK150.47621255
122CDK11A0.46320240
123MAP2K30.46113383
124CDK180.45843587
125PDK20.42973057
126CAMK10.42899229
127HCK0.42519677
128CDK120.41349084
129CAMK2G0.41164414
130ILK0.41131996
131MAPK40.40459379
132STK380.39658816
133PAK20.39473236
134FYN0.38782152
135PRKCH0.38369797
136SIK20.36944072
137UHMK10.36201358
138MAP3K70.35598020
139CDK50.35201137
140PRKG20.35179853
141TAOK20.34689146
142MAPK110.34451081
143CSNK1G20.33807832
144BTK0.33658423
145CSNK1G30.32393859
146CCNB10.30628699
147PTK60.28998148
148MARK30.28491859

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.13096222
2Vitamin B6 metabolism_Homo sapiens_hsa007503.65223910
3Synaptic vesicle cycle_Homo sapiens_hsa047213.25387759
4Regulation of autophagy_Homo sapiens_hsa041403.13353587
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.00159013
6Folate biosynthesis_Homo sapiens_hsa007902.29838190
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.24022565
8Collecting duct acid secretion_Homo sapiens_hsa049662.21652318
9Lysosome_Homo sapiens_hsa041422.15789689
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.12270336
11Fructose and mannose metabolism_Homo sapiens_hsa000511.99217354
12Vibrio cholerae infection_Homo sapiens_hsa051101.98233134
13Acute myeloid leukemia_Homo sapiens_hsa052211.86198567
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76849332
15RNA polymerase_Homo sapiens_hsa030201.71800114
16Pentose phosphate pathway_Homo sapiens_hsa000301.69441673
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67344635
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64530977
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52841558
20Notch signaling pathway_Homo sapiens_hsa043301.49057261
21* Glycerophospholipid metabolism_Homo sapiens_hsa005641.46512669
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46280299
23Chronic myeloid leukemia_Homo sapiens_hsa052201.44246848
24Osteoclast differentiation_Homo sapiens_hsa043801.43402151
25Non-small cell lung cancer_Homo sapiens_hsa052231.38526926
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32049051
27Endocytosis_Homo sapiens_hsa041441.29643228
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28081052
29B cell receptor signaling pathway_Homo sapiens_hsa046621.26301922
30N-Glycan biosynthesis_Homo sapiens_hsa005101.23472781
31Oocyte meiosis_Homo sapiens_hsa041141.23130330
32Shigellosis_Homo sapiens_hsa051311.21831825
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21595109
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.21224723
35Long-term potentiation_Homo sapiens_hsa047201.20997899
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13389977
37Protein export_Homo sapiens_hsa030601.12055828
38RNA transport_Homo sapiens_hsa030131.11644196
39Insulin secretion_Homo sapiens_hsa049111.11307729
40Galactose metabolism_Homo sapiens_hsa000521.10694726
41Amoebiasis_Homo sapiens_hsa051461.10132431
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08879105
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07715229
44Biosynthesis of amino acids_Homo sapiens_hsa012301.06354698
45VEGF signaling pathway_Homo sapiens_hsa043701.05993799
46mTOR signaling pathway_Homo sapiens_hsa041501.03429033
47Pancreatic cancer_Homo sapiens_hsa052121.03345453
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02114082
49Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99814417
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.99110358
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98607090
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.98196326
53Focal adhesion_Homo sapiens_hsa045100.98124436
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97868884
55Malaria_Homo sapiens_hsa051440.96336779
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95815677
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94599798
58Endometrial cancer_Homo sapiens_hsa052130.93091852
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89278440
60Prion diseases_Homo sapiens_hsa050200.88487532
61Pyrimidine metabolism_Homo sapiens_hsa002400.87713451
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.86709965
63Hepatitis C_Homo sapiens_hsa051600.84666666
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84129502
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83955832
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.83945203
67Leishmaniasis_Homo sapiens_hsa051400.82149036
68Carbon metabolism_Homo sapiens_hsa012000.81933509
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81493331
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80931431
71Pancreatic secretion_Homo sapiens_hsa049720.80930258
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79527886
73AMPK signaling pathway_Homo sapiens_hsa041520.79313770
74ErbB signaling pathway_Homo sapiens_hsa040120.78994612
75ECM-receptor interaction_Homo sapiens_hsa045120.78487055
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.77974385
77Gap junction_Homo sapiens_hsa045400.77064933
78Tuberculosis_Homo sapiens_hsa051520.76921516
79Salmonella infection_Homo sapiens_hsa051320.73959247
80Vitamin digestion and absorption_Homo sapiens_hsa049770.73928545
81Staphylococcus aureus infection_Homo sapiens_hsa051500.73676247
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72936529
83Choline metabolism in cancer_Homo sapiens_hsa052310.72769309
84GABAergic synapse_Homo sapiens_hsa047270.72489084
85Thyroid cancer_Homo sapiens_hsa052160.72413815
86Other glycan degradation_Homo sapiens_hsa005110.71871249
87Renin-angiotensin system_Homo sapiens_hsa046140.71572206
88Dopaminergic synapse_Homo sapiens_hsa047280.71560128
89Proteoglycans in cancer_Homo sapiens_hsa052050.70067816
90Rap1 signaling pathway_Homo sapiens_hsa040150.69698626
91Amphetamine addiction_Homo sapiens_hsa050310.69173199
92Phenylalanine metabolism_Homo sapiens_hsa003600.68936703
93Epstein-Barr virus infection_Homo sapiens_hsa051690.68046636
94Apoptosis_Homo sapiens_hsa042100.67765119
95Chemokine signaling pathway_Homo sapiens_hsa040620.67468382
96Bile secretion_Homo sapiens_hsa049760.67209834
97Melanogenesis_Homo sapiens_hsa049160.66757526
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65879218
99Estrogen signaling pathway_Homo sapiens_hsa049150.65191691
100Sulfur relay system_Homo sapiens_hsa041220.65124011
101Insulin resistance_Homo sapiens_hsa049310.64243788
102Antigen processing and presentation_Homo sapiens_hsa046120.63411281
103* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63285157
104Toxoplasmosis_Homo sapiens_hsa051450.61145464
105Platelet activation_Homo sapiens_hsa046110.60779721
106Purine metabolism_Homo sapiens_hsa002300.60347975
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60233758
108Mineral absorption_Homo sapiens_hsa049780.59393559
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.59313128
110Bladder cancer_Homo sapiens_hsa052190.58290994
111MAPK signaling pathway_Homo sapiens_hsa040100.57960657
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57833444
113Hepatitis B_Homo sapiens_hsa051610.57675374
114Pertussis_Homo sapiens_hsa051330.57012120
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56924002
116Renal cell carcinoma_Homo sapiens_hsa052110.56846117
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56591051
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55858612
119Gastric acid secretion_Homo sapiens_hsa049710.54400660
120TNF signaling pathway_Homo sapiens_hsa046680.54047073
121Protein digestion and absorption_Homo sapiens_hsa049740.53778240
122* Inositol phosphate metabolism_Homo sapiens_hsa005620.53603123
123GnRH signaling pathway_Homo sapiens_hsa049120.52726638
124Fat digestion and absorption_Homo sapiens_hsa049750.51922571
125Salivary secretion_Homo sapiens_hsa049700.51154285
126Insulin signaling pathway_Homo sapiens_hsa049100.50306881
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.50296437
128Complement and coagulation cascades_Homo sapiens_hsa046100.48284355
129Arginine biosynthesis_Homo sapiens_hsa002200.48283363
130Circadian entrainment_Homo sapiens_hsa047130.48236408
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47780076
132Glycerolipid metabolism_Homo sapiens_hsa005610.47668903
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47418513
134Glioma_Homo sapiens_hsa052140.44573057
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.43832353
136Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43535941
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.42744900
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.41836966
139HIF-1 signaling pathway_Homo sapiens_hsa040660.41462605
140Cholinergic synapse_Homo sapiens_hsa047250.40763080
141Oxytocin signaling pathway_Homo sapiens_hsa049210.40339209
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39964602
143Ribosome_Homo sapiens_hsa030100.38077451
144Prolactin signaling pathway_Homo sapiens_hsa049170.37565107
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.37484973
146Oxidative phosphorylation_Homo sapiens_hsa001900.37330465
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36560595
148Rheumatoid arthritis_Homo sapiens_hsa053230.36446395
149Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35752778
150Cocaine addiction_Homo sapiens_hsa050300.35260522
151Olfactory transduction_Homo sapiens_hsa047400.35072918
152Phagosome_Homo sapiens_hsa041450.34517895

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