ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of catecholamine secretion (GO:0033605)	9.63943113
2	male meiosis (GO:0007140)	9.51058147
3	sperm motility (GO:0030317)	9.50202756
4	spermatid development (GO:0007286)	9.14734362
5	binding of sperm to zona pellucida (GO:0007339)	8.24742649
6	multicellular organism reproduction (GO:0032504)	7.99553249
7	motile cilium assembly (GO:0044458)	7.34015658
8	regulation of oxidative stress-induced neuron death (GO:1903203)	7.15584938
9	axonemal dynein complex assembly (GO:0070286)	6.87298547
10	nucleosome disassembly (GO:0006337)	6.83398612
11	protein-DNA complex disassembly (GO:0032986)	6.83398612
12	sperm-egg recognition (GO:0035036)	6.79666350
13	regulation of oxidative phosphorylation (GO:0002082)	6.79358007
14	polyamine biosynthetic process (GO:0006596)	6.48530429
15	relaxation of smooth muscle (GO:0044557)	6.36796752
16	potassium ion export (GO:0071435)	6.22018103
17	cilium or flagellum-dependent cell motility (GO:0001539)	6.12213659
18	organic cation transport (GO:0015695)	6.05713285
19	cell-cell recognition (GO:0009988)	5.89005268
20	reproduction (GO:0000003)	5.88419709
21	epithelial cilium movement (GO:0003351)	5.76769621
22	synapsis (GO:0007129)	5.64342026
23	activation of protein kinase B activity (GO:0032148)	5.62967746
24	fusion of sperm to egg plasma membrane (GO:0007342)	5.48778704
25	single fertilization (GO:0007338)	5.42515330
26	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	5.36610087
27	germ cell development (GO:0007281)	5.30851861
28	male sex determination (GO:0030238)	5.30641990
29	Leydig cell differentiation (GO:0033327)	5.30447846
30	cGMP-mediated signaling (GO:0019934)	5.25081219
31	response to acidic pH (GO:0010447)	4.91321320
32	regulation of hydrogen peroxide-induced cell death (GO:1903205)	4.88643751
33	negative regulation of response to reactive oxygen species (GO:1901032)	4.88463656
34	regulation of autophagic vacuole assembly (GO:2000785)	4.83378291
35	regulation of dopamine secretion (GO:0014059)	4.78714219
36	positive regulation of glycolytic process (GO:0045821)	4.78440485
37	calcium ion-dependent exocytosis (GO:0017156)	4.74770727
38	cilium movement (GO:0003341)	4.70211441
39	protein polymerization (GO:0051258)	4.58560196
40	glutamine family amino acid catabolic process (GO:0009065)	4.57858747
41	TOR signaling (GO:0031929)	4.57382534
42	histone exchange (GO:0043486)	4.54052428
43	regulation of cellular respiration (GO:0043457)	4.53655693
44	coenzyme catabolic process (GO:0009109)	4.51199343
45	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.44481782
46	negative regulation of inclusion body assembly (GO:0090084)	4.39291926
47	androgen biosynthetic process (GO:0006702)	4.38957441
48	ventricular system development (GO:0021591)	4.37478360
49	amine biosynthetic process (GO:0009309)	4.36778080
50	cellular biogenic amine biosynthetic process (GO:0042401)	4.34693882
51	glycogen metabolic process (GO:0005977)	4.33022451
52	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.31577219
53	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	4.30515900
54	cellular glucan metabolic process (GO:0006073)	4.28769950
55	glucan metabolic process (GO:0044042)	4.28769950
56	plasma membrane fusion (GO:0045026)	4.26489891
57	oogenesis (GO:0048477)	4.24662625
58	mitochondrion degradation (GO:0000422)	4.21176642
59	chromosome organization involved in meiosis (GO:0070192)	4.20136664
60	regulation of synaptic transmission, dopaminergic (GO:0032225)	4.17768408
61	acrosome assembly (GO:0001675)	4.15700500
62	tongue development (GO:0043586)	4.14760216
63	phosphatidylethanolamine metabolic process (GO:0046337)	4.05872064
64	regulation of vacuole organization (GO:0044088)	3.93884773
65	meiotic nuclear division (GO:0007126)	3.93335284
66	fertilization (GO:0009566)	3.93079239
67	polyamine metabolic process (GO:0006595)	3.89750715
68	regulation of phosphatase activity (GO:0010921)	3.75030013
69	membrane repolarization during action potential (GO:0086011)	3.73403401
70	diacylglycerol metabolic process (GO:0046339)	3.73363742
71	piRNA metabolic process (GO:0034587)	3.70427362
72	DNA double-strand break processing (GO:0000729)	3.66266118
73	positive regulation of amine transport (GO:0051954)	3.65912673
74	aspartate family amino acid catabolic process (GO:0009068)	3.65899634
75	spermatogenesis (GO:0007283)	3.62362135
76	male gamete generation (GO:0048232)	3.60814406
77	sperm capacitation (GO:0048240)	3.55175438
78	cellular response to pH (GO:0071467)	3.45187200
79	negative regulation of JNK cascade (GO:0046329)	3.45113504
80	membrane repolarization (GO:0086009)	3.45002842
81	histone H3-K9 demethylation (GO:0033169)	3.39510038
82	gamete generation (GO:0007276)	3.37551572
83	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)	3.35152506
84	cellular response to toxic substance (GO:0097237)	3.32017732
85	negative regulation of smooth muscle contraction (GO:0045986)	3.31923578
86	synaptonemal complex assembly (GO:0007130)	3.26189522
87	dicarboxylic acid biosynthetic process (GO:0043650)	3.22262913
88	spermatid nucleus differentiation (GO:0007289)	3.19782760
89	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.12235599
90	oligosaccharide biosynthetic process (GO:0009312)	3.09354486
91	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.06170778
92	indole-containing compound catabolic process (GO:0042436)	3.06147551
93	indolalkylamine catabolic process (GO:0046218)	3.06147551
94	tryptophan catabolic process (GO:0006569)	3.06147551
95	regulation of inclusion body assembly (GO:0090083)	3.06071750
96	negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)	3.05184637
97	negative regulation of stress-activated MAPK cascade (GO:0032873)	3.05184637
98	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	10.6760470
99	regulation of phosphoprotein phosphatase activity (GO:0043666)	10.3794677
100	acrosome reaction (GO:0007340)	10.1730139

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	8.89158734
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.61290219
3	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.62598408
4	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	3.25232114
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.11302690
6	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.85264102
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.67070001
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34772742
9	FUS_26573619_Chip-Seq_HEK293_Human	2.26341733
10	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.18332973
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.16924172
12	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.05681250
13	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.05681250
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	10.2888201
15	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.98298678
16	NANOG_20526341_ChIP-Seq_ESCs_Human	1.95829777
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.94687568
18	AHR_22903824_ChIP-Seq_MCF-7_Human	1.87441413
19	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.86608590
20	AR_21572438_ChIP-Seq_LNCaP_Human	1.84415145
21	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.79985925
22	GBX2_23144817_ChIP-Seq_PC3_Human	1.71430022
23	RAC3_21632823_ChIP-Seq_H3396_Human	1.71050629
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68813463
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.68813463
26	CTCF_27219007_Chip-Seq_Bcells_Human	1.67349773
27	ERA_21632823_ChIP-Seq_H3396_Human	1.63142789
28	AR_21909140_ChIP-Seq_LNCAP_Human	1.60322102
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.58043143
30	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.55027883
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54022045
32	OCT4_20526341_ChIP-Seq_ESCs_Human	1.52127623
33	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.49304858
34	SMC4_20622854_ChIP-Seq_HELA_Human	1.48139178
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45912387
36	TBL1_22424771_ChIP-Seq_293T_Human	1.41764639
37	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.39257026
38	MYC_19829295_ChIP-Seq_ESCs_Human	1.39053622
39	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.36021989
40	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.33847796
41	ERG_20517297_ChIP-Seq_VCAP_Human	1.32186708
42	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.27965072
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.27793148
44	TP53_18474530_ChIP-ChIP_U2OS_Human	1.26246187
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25901137
46	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.22701253
47	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.21586310
48	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20156276
49	VDR_22108803_ChIP-Seq_LS180_Human	1.19355550
50	CTCF_20526341_ChIP-Seq_ESCs_Human	1.18350386
51	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.17513437
52	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.16933495
53	P300_19829295_ChIP-Seq_ESCs_Human	1.15960543
54	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.08459271
55	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07460100
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.06794093
57	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.06762469
58	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.03890800
59	AR_25329375_ChIP-Seq_VCAP_Human	1.03693819
60	SPI1_20517297_ChIP-Seq_HL60_Human	1.03052759
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02461510
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02461510
63	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.01699524
64	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.01099125
65	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99115113
66	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.97997084
67	P300_27268052_Chip-Seq_Bcells_Human	0.97637954
68	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.96876763
69	PHF8_20622854_ChIP-Seq_HELA_Human	0.96818929
70	P68_20966046_ChIP-Seq_HELA_Human	0.94314869
71	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.93962486
72	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93868613
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.93629989
74	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92515909
75	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.92489297
76	PHF8_20622853_ChIP-Seq_HELA_Human	0.92322885
77	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.91472202
78	NFYB_21822215_ChIP-Seq_K562_Human	0.90597774
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88209276
80	RXR_22108803_ChIP-Seq_LS180_Human	0.87269748
81	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.87149829
82	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.86659017
83	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.86387989
84	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.85766440
85	LXR_22292898_ChIP-Seq_THP-1_Human	0.85453896
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.84669448
87	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.84053048
88	RBPJ_21746931_ChIP-Seq_IB4_Human	0.82941906
89	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.82926639
90	ELF5_23300383_ChIP-Seq_T47D_Human	0.81850641
91	ZNF274_21170338_ChIP-Seq_K562_Hela	0.81433688
92	STAT3_23295773_ChIP-Seq_U87_Human	0.81378706
93	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.80891351
94	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.80546310
95	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.79891480
96	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.79142983
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.78236853
98	TP63_22573176_ChIP-Seq_HFKS_Human	0.78003949
99	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.77850594
100	E2F1_20622854_ChIP-Seq_HELA_Human	0.77474563

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003315_abnormal_perineum_morphology	6.70222874
2	MP0008004_abnormal_stomach_pH	5.95760474
3	MP0005360_urolithiasis	3.94814281
4	MP0002160_abnormal_reproductive_system	3.63777779
5	MP0003698_abnormal_male_reproductive	3.59078317
6	MP0001929_abnormal_gametogenesis	3.26690849
7	MP0003045_fibrosis	2.57029530
8	MP0003136_yellow_coat_color	2.50223076
9	MP0005058_abnormal_lysosome_morphology	2.49617798
10	MP0002132_abnormal_respiratory_system	2.47600939
11	MP0000537_abnormal_urethra_morphology	2.33638523
12	MP0001984_abnormal_olfaction	2.24561293
13	MP0005647_abnormal_sex_gland	2.16843111
14	MP0005410_abnormal_fertilization	10.0829937
15	MP0010386_abnormal_urinary_bladder	1.99296962
16	MP0005499_abnormal_olfactory_system	1.98034215
17	MP0005394_taste/olfaction_phenotype	1.98034215
18	MP0002161_abnormal_fertility/fecundity	1.93341224
19	MP0002210_abnormal_sex_determination	1.90609087
20	MP0005187_abnormal_penis_morphology	1.82958784
21	MP0001664_abnormal_digestion	1.82067215
22	MP0005389_reproductive_system_phenotype	1.77124971
23	MP0001188_hyperpigmentation	1.75196823
24	MP0001145_abnormal_male_reproductive	1.70245304
25	MP0010368_abnormal_lymphatic_system	1.64824273
26	MP0001905_abnormal_dopamine_level	1.63016493
27	MP0003718_maternal_effect	1.56213402
28	MP0000653_abnormal_sex_gland	1.56097249
29	MP0008995_early_reproductive_senescence	1.49693276
30	MP0000538_abnormal_urinary_bladder	1.44334751
31	MP0006072_abnormal_retinal_apoptosis	1.33326274
32	MP0009697_abnormal_copulation	1.27463480
33	MP0009840_abnormal_foam_cell	1.25516384
34	MP0006036_abnormal_mitochondrial_physio	1.21744022
35	MP0005395_other_phenotype	1.14005894
36	MP0000678_abnormal_parathyroid_gland	1.13735494
37	MP0003878_abnormal_ear_physiology	1.10113746
38	MP0005377_hearing/vestibular/ear_phenot	1.10113746
39	MP0002127_abnormal_cardiovascular_syste	1.08430490
40	MP0005646_abnormal_pituitary_gland	1.03744979
41	MP0003936_abnormal_reproductive_system	1.03625690
42	MP0001849_ear_inflammation	1.03477804
43	MP0001919_abnormal_reproductive_system	1.00982963
44	MP0002249_abnormal_larynx_morphology	1.00672571
45	MP0004272_abnormal_basement_membrane	1.00573861
46	MP0003632_abnormal_nervous_system	1.00421828
47	MP0005248_abnormal_Harderian_gland	0.94513556
48	MP0001529_abnormal_vocalization	0.91690863
49	MP0003879_abnormal_hair_cell	0.89553168
50	MP0004085_abnormal_heartbeat	0.88636127
51	MP0005409_darkened_coat_color	0.86933353
52	MP0000465_gastrointestinal_hemorrhage	0.85955976
53	MP0003806_abnormal_nucleotide_metabolis	0.85330919
54	MP0002168_other_aberrant_phenotype	0.84873038
55	MP0000343_altered_response_to	0.84600372
56	MP0003631_nervous_system_phenotype	0.81173863
57	MP0000631_abnormal_neuroendocrine_gland	0.80561750
58	MP0008789_abnormal_olfactory_epithelium	0.76884049
59	MP0001501_abnormal_sleep_pattern	0.76801067
60	MP0000470_abnormal_stomach_morphology	0.76628961
61	MP0005253_abnormal_eye_physiology	0.74349437
62	MP0002233_abnormal_nose_morphology	0.72974405
63	MP0004084_abnormal_cardiac_muscle	0.72425800
64	MP0003385_abnormal_body_wall	0.65021018
65	MP0003938_abnormal_ear_development	0.60190011
66	MP0004036_abnormal_muscle_relaxation	0.59727480
67	MP0000049_abnormal_middle_ear	0.59673050
68	MP0003633_abnormal_nervous_system	0.58277355
69	MP0002272_abnormal_nervous_system	0.58068236
70	MP0005670_abnormal_white_adipose	0.57237495
71	MP0001270_distended_abdomen	0.56738198
72	MP0002102_abnormal_ear_morphology	0.56696481
73	MP0002090_abnormal_vision	0.55887021
74	MP0000566_synostosis	0.55735601
75	MP0001485_abnormal_pinna_reflex	0.55648037
76	MP0000230_abnormal_systemic_arterial	0.55638565
77	MP0010234_abnormal_vibrissa_follicle	0.54031586
78	MP0001756_abnormal_urination	0.52492687
79	MP0005174_abnormal_tail_pigmentation	0.51912402
80	MP0000462_abnormal_digestive_system	0.51378323
81	MP0004381_abnormal_hair_follicle	0.50893734
82	MP0002638_abnormal_pupillary_reflex	0.50449645
83	MP0001661_extended_life_span	0.50288956
84	MP0004859_abnormal_synaptic_plasticity	0.49573381
85	MP0008877_abnormal_DNA_methylation	0.49324154
86	MP0005551_abnormal_eye_electrophysiolog	0.48566434
87	MP0001968_abnormal_touch/_nociception	0.47432581
88	MP0000026_abnormal_inner_ear	0.45272011
89	MP0003635_abnormal_synaptic_transmissio	0.45001706
90	MP0001486_abnormal_startle_reflex	0.44117223
91	MP0005595_abnormal_vascular_smooth	0.42220296
92	MP0001963_abnormal_hearing_physiology	0.41563603
93	MP0008058_abnormal_DNA_repair	0.40033113
94	MP0003693_abnormal_embryo_hatching	0.39935526
95	MP0005391_vision/eye_phenotype	0.39913612
96	MP0002752_abnormal_somatic_nervous	0.39812522
97	MP0000681_abnormal_thyroid_gland	0.39154247
98	MP0005620_abnormal_muscle_contractility	0.39005580
99	MP0001764_abnormal_homeostasis	0.38569848
100	MP0002282_abnormal_trachea_morphology	0.38304483

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Resting tremor (HP:0002322)	7.68651313
2	Sex reversal (HP:0012245)	7.58223566
3	Abnormal sex determination (HP:0012244)	7.58223566
4	Hypoplasia of the uterus (HP:0000013)	7.23512547
5	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.50140977
6	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.13728991
7	Absent/shortened dynein arms (HP:0200106)	6.13728991
8	Abnormal respiratory motile cilium physiology (HP:0012261)	5.87589526
9	Abnormal ciliary motility (HP:0012262)	5.68709310
10	Aplasia/hypoplasia of the uterus (HP:0008684)	5.56524383
11	Gonadal dysgenesis (HP:0000133)	5.38939045
12	Reduced antithrombin III activity (HP:0001976)	5.25397752
13	Abnormality of the columella (HP:0009929)	5.19665581
14	Infertility (HP:0000789)	4.87358289
15	Postural instability (HP:0002172)	4.64637535
16	Male pseudohermaphroditism (HP:0000037)	4.62832021
17	Colitis (HP:0002583)	4.59457187
18	Abnormal respiratory epithelium morphology (HP:0012253)	4.58301942
19	Abnormal respiratory motile cilium morphology (HP:0005938)	4.58301942
20	Facial hemangioma (HP:0000329)	4.19276410
21	Ventricular fibrillation (HP:0001663)	4.18755023
22	Germ cell neoplasia (HP:0100728)	4.05216645
23	Cerebellar dysplasia (HP:0007033)	3.93769749
24	Thoracic kyphosis (HP:0002942)	3.57956419
25	Rhinitis (HP:0012384)	3.53213727
26	Nasal polyposis (HP:0100582)	3.39204637
27	Thoracolumbar scoliosis (HP:0002944)	3.37774370
28	Type II lissencephaly (HP:0007260)	3.37453379
29	Self-mutilation (HP:0000742)	3.36160390
30	Urinary urgency (HP:0000012)	3.35587969
31	Retinal atrophy (HP:0001105)	3.31117966
32	Retinal dysplasia (HP:0007973)	3.03415763
33	Abnormality of the intrinsic pathway (HP:0010989)	3.02950046
34	Occipital encephalocele (HP:0002085)	2.94182552
35	Inflammation of the large intestine (HP:0002037)	2.90946894
36	Abnormality of the lumbar spine (HP:0100712)	2.90441863
37	Abnormality of the nasal mucosa (HP:0000433)	2.90333275
38	Sensory axonal neuropathy (HP:0003390)	2.89255009
39	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.85789511
40	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.85789511
41	Capillary hemangiomas (HP:0005306)	2.84218104
42	Atonic seizures (HP:0010819)	2.78024315
43	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.71733934
44	Gastrointestinal inflammation (HP:0004386)	2.68636871
45	Protruding tongue (HP:0010808)	2.56193096
46	Congenital sensorineural hearing impairment (HP:0008527)	2.54044446
47	Chronic bronchitis (HP:0004469)	2.52564805
48	Tubulointerstitial nephritis (HP:0001970)	2.49430842
49	Unsteady gait (HP:0002317)	2.44230348
50	Bronchiectasis (HP:0002110)	2.42434689
51	Absent thumb (HP:0009777)	2.41750102
52	Buphthalmos (HP:0000557)	2.38328800
53	Anterior segment dysgenesis (HP:0007700)	2.35878612
54	Abnormality of the thoracic spine (HP:0100711)	2.33670553
55	Abnormality of the frontal sinuses (HP:0002687)	2.30552637
56	Hypothermia (HP:0002045)	2.29194088
57	Abnormality of male internal genitalia (HP:0000022)	2.19190995
58	Inability to walk (HP:0002540)	2.17803362
59	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.15886792
60	Renal dysplasia (HP:0000110)	2.15566238
61	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.11928735
62	Abnormality of the ileum (HP:0001549)	2.08259794
63	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	2.01900576
64	Chronic hepatic failure (HP:0100626)	2.00745972
65	Syncope (HP:0001279)	1.97211443
66	Prolonged QT interval (HP:0001657)	1.93857857
67	Optic nerve hypoplasia (HP:0000609)	1.91550745
68	Median cleft lip (HP:0000161)	1.90440124
69	High anterior hairline (HP:0009890)	1.87670744
70	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.85444115
71	Spinal rigidity (HP:0003306)	1.84252108
72	Meckel diverticulum (HP:0002245)	1.83817870
73	Abnormality of macular pigmentation (HP:0008002)	1.83425049
74	Flattened epiphyses (HP:0003071)	1.78263528
75	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.76960797
76	Abnormal protein N-linked glycosylation (HP:0012347)	1.76960797
77	Abnormal protein glycosylation (HP:0012346)	1.76960797
78	Abnormal glycosylation (HP:0012345)	1.76960797
79	Abnormal rod and cone electroretinograms (HP:0008323)	1.76806298
80	Polyneuropathy (HP:0001271)	1.75015832
81	Recurrent corneal erosions (HP:0000495)	1.74488401
82	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.73098936
83	Bradykinesia (HP:0002067)	1.71608483
84	Chronic sinusitis (HP:0011109)	1.71305904
85	Facial diplegia (HP:0001349)	1.70015542
86	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.69871949
87	Abnormal drinking behavior (HP:0030082)	1.68138282
88	Polydipsia (HP:0001959)	1.68138282
89	Abnormality of the dental root (HP:0006486)	1.65118173
90	Taurodontia (HP:0000679)	1.65118173
91	Abnormality of permanent molar morphology (HP:0011071)	1.65118173
92	Male infertility (HP:0003251)	1.62467046
93	Esophageal atresia (HP:0002032)	1.60400274
94	Absent speech (HP:0001344)	1.58097003
95	Rhabdomyolysis (HP:0003201)	1.57915218
96	Hypoplasia of the brainstem (HP:0002365)	1.55291116
97	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.55291116
98	Bony spicule pigmentary retinopathy (HP:0007737)	1.54850102
99	Aplasia cutis congenita (HP:0001057)	1.53793523
100	Coxa valga (HP:0002673)	1.53498445

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK3	6.16742161
2	TLK1	4.35198279
3	ZAK	3.81497194
4	MYLK	3.21284627
5	RPS6KA5	2.82154753
6	NEK2	2.43264529
7	LATS1	2.07802408
8	PINK1	11.7668872
9	STK38	1.87994157
10	STK38L	1.58694683
11	MAP2K7	1.31157674
12	CDK3	1.25757767
13	MST1R	1.17551398
14	LATS2	1.16353815
15	PLK4	1.11357036
16	BMPR1B	1.11121623
17	MAPK15	1.07748089
18	MAP3K9	1.04297997
19	SGK494	1.00291297
20	SGK223	1.00291297
21	CSNK1A1L	0.99082485
22	FRK	0.96742026
23	ARAF	0.87997805
24	CSNK1G3	0.84236354
25	VRK1	0.81989798
26	DYRK3	0.80130951
27	CDK14	0.78350281
28	NME2	0.75770831
29	PRKCQ	0.75201227
30	CDC42BPA	0.72821671
31	FGFR2	0.72045290
32	MELK	0.66600493
33	CSNK1G1	0.66388672
34	OBSCN	0.66275669
35	MAP3K1	0.65933193
36	CSNK1G2	0.65445556
37	PRKD3	0.63279955
38	DYRK2	0.55104844
39	MUSK	0.54907784
40	PAK1	0.53473262
41	PRKG2	0.52634930
42	PDPK1	0.52135771
43	PKN1	0.49342434
44	FGR	0.47275800
45	DAPK3	0.45921860
46	ICK	0.44450067
47	PAK2	0.44181118
48	MAP3K13	0.41203736
49	CDK5	0.40150024
50	CAMK1	0.39485261
51	CDK8	0.39312512
52	PTK2B	0.38469770
53	PRKG1	0.37782050
54	ROCK1	0.36850571
55	ATM	0.36478508
56	MAP3K5	0.35986920
57	TIE1	0.35606302
58	EIF2AK3	0.35583737
59	PDK1	0.35345017
60	BRAF	0.35144946
61	PNCK	0.33364186
62	TGFBR1	0.33315445
63	RPS6KB1	0.32394244
64	RET	0.32079943
65	EGFR	0.30693065
66	PIK3CG	0.30021750
67	CDK12	0.26646754
68	ADRBK2	0.26594896
69	MAP3K10	0.25883015
70	MOS	0.25674940
71	ILK	0.25623033
72	AKT2	0.24773484
73	STK3	0.24543230
74	CSNK1A1	0.23581516
75	MTOR	0.22694596
76	RPS6KA1	0.22030975
77	INSRR	0.21791480
78	PBK	0.20871929
79	AKT3	0.19731659
80	CCNB1	0.18716006
81	PLK1	0.18698615
82	GRK1	0.18661789
83	PLK2	0.17689333
84	AURKB	0.16009958
85	KSR2	0.15575221
86	MAP3K2	0.15344788
87	RPS6KA3	0.15017238
88	IRAK2	0.14876525
89	CAMK1G	0.14521738
90	AURKA	0.14128418
91	SGK2	0.13673426
92	MAPK1	0.13597531
93	BRD4	0.13450659
94	MINK1	0.12115415
95	RPS6KA4	0.12105810
96	MET	0.11858308
97	STK16	0.11855353
98	WEE1	0.11124363
99	WNK3	0.10186369
100	EEF2K	0.09848024

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	7.79021436
2	Gap junction_Homo sapiens_hsa04540	5.30260438
3	Hedgehog signaling pathway_Homo sapiens_hsa04340	3.55933968
4	Nitrogen metabolism_Homo sapiens_hsa00910	3.47627329
5	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.22913085
6	Apoptosis_Homo sapiens_hsa04210	2.80516573
7	Phagosome_Homo sapiens_hsa04145	2.71621878
8	Arginine biosynthesis_Homo sapiens_hsa00220	2.62811789
9	Alcoholism_Homo sapiens_hsa05034	2.49301551
10	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.47116337
11	Olfactory transduction_Homo sapiens_hsa04740	2.42753936
12	Propanoate metabolism_Homo sapiens_hsa00640	2.21687018
13	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.11812801
14	Butanoate metabolism_Homo sapiens_hsa00650	1.94506406
15	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.75080793
16	Pyruvate metabolism_Homo sapiens_hsa00620	1.67433345
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.57649931
18	Glutathione metabolism_Homo sapiens_hsa00480	1.55869942
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.49710485
20	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.41496502
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.30161886
22	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.26510566
23	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.15081069
24	Phenylalanine metabolism_Homo sapiens_hsa00360	1.10225659
25	Oocyte meiosis_Homo sapiens_hsa04114	1.03226441
26	Glucagon signaling pathway_Homo sapiens_hsa04922	1.02784959
27	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.01667306
28	PPAR signaling pathway_Homo sapiens_hsa03320	1.01049985
29	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97186954
30	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.94358521
31	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.91308740
32	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.90998165
33	Pentose phosphate pathway_Homo sapiens_hsa00030	0.89256976
34	Taste transduction_Homo sapiens_hsa04742	0.87591624
35	Fatty acid degradation_Homo sapiens_hsa00071	0.87318754
36	Basal transcription factors_Homo sapiens_hsa03022	0.82895015
37	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.76566609
38	Renin secretion_Homo sapiens_hsa04924	0.76234413
39	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74695693
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.73662552
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71162453
42	Purine metabolism_Homo sapiens_hsa00230	0.66068764
43	mRNA surveillance pathway_Homo sapiens_hsa03015	0.65170739
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.64358367
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.63576639
46	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.62873034
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.61556286
48	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.60356685
49	RNA transport_Homo sapiens_hsa03013	0.57147727
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.55078276
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55039392
52	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.54532063
53	Fatty acid metabolism_Homo sapiens_hsa01212	0.51531518
54	Gastric acid secretion_Homo sapiens_hsa04971	0.50979748
55	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.50141831
56	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.48978926
57	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.48618260
58	Circadian rhythm_Homo sapiens_hsa04710	0.46554055
59	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45527518
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42615362
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41659461
62	Wnt signaling pathway_Homo sapiens_hsa04310	0.41494504
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.39389860
64	Metabolic pathways_Homo sapiens_hsa01100	0.39036203
65	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.38329030
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36622039
67	Carbon metabolism_Homo sapiens_hsa01200	0.33881821
68	Circadian entrainment_Homo sapiens_hsa04713	0.29649775
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.25463756
70	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.24286088
71	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.24116191
72	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.23930189
73	RNA degradation_Homo sapiens_hsa03018	0.22990801
74	Endometrial cancer_Homo sapiens_hsa05213	0.22983235
75	Estrogen signaling pathway_Homo sapiens_hsa04915	0.22949526
76	Regulation of autophagy_Homo sapiens_hsa04140	0.22890801
77	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.22589566
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.22573941
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.22451676
80	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.20839356
81	Retinol metabolism_Homo sapiens_hsa00830	0.20580748
82	Peroxisome_Homo sapiens_hsa04146	0.20235833
83	Pyrimidine metabolism_Homo sapiens_hsa00240	0.20228667
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.20156164
85	Prostate cancer_Homo sapiens_hsa05215	0.19105008
86	Amphetamine addiction_Homo sapiens_hsa05031	0.18018721
87	Long-term potentiation_Homo sapiens_hsa04720	0.17526193
88	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.15778935
89	Sulfur relay system_Homo sapiens_hsa04122	0.15638269
90	DNA replication_Homo sapiens_hsa03030	0.15583337
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.15478690
92	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.12962309
93	Choline metabolism in cancer_Homo sapiens_hsa05231	0.12360965
94	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.10922682
95	Viral carcinogenesis_Homo sapiens_hsa05203	0.10274686
96	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.10018502
97	Phototransduction_Homo sapiens_hsa04744	0.09549569
98	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.09534349
99	MAPK signaling pathway_Homo sapiens_hsa04010	0.09065391
100	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.08455748

CDIPT-AS1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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