CDK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.49676035
2DNA ligation (GO:0006266)5.46868607
3DNA topological change (GO:0006265)5.12904854
4* protein localization to kinetochore (GO:0034501)4.91753527
5kinetochore organization (GO:0051383)4.82609795
6mitotic sister chromatid segregation (GO:0000070)4.81609799
7metaphase plate congression (GO:0051310)4.81214242
8CENP-A containing nucleosome assembly (GO:0034080)4.77663555
9regulation of spindle organization (GO:0090224)4.75255537
10DNA strand elongation involved in DNA replication (GO:0006271)4.73763943
11chromatin remodeling at centromere (GO:0031055)4.65329095
12attachment of spindle microtubules to kinetochore (GO:0008608)4.53389753
13DNA replication initiation (GO:0006270)4.52758390
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.51112461
15telomere maintenance via semi-conservative replication (GO:0032201)4.50212178
16DNA strand elongation (GO:0022616)4.49685757
17sister chromatid segregation (GO:0000819)4.46473913
18mitotic chromosome condensation (GO:0007076)4.42801160
19DNA unwinding involved in DNA replication (GO:0006268)4.42133055
20establishment of chromosome localization (GO:0051303)4.38824285
21DNA replication checkpoint (GO:0000076)4.38164631
22kinetochore assembly (GO:0051382)4.37008946
23* protein localization to chromosome, centromeric region (GO:0071459)4.36849712
24DNA replication-independent nucleosome organization (GO:0034724)4.29509713
25DNA replication-independent nucleosome assembly (GO:0006336)4.29509713
26mitotic sister chromatid cohesion (GO:0007064)4.28422571
27DNA replication-dependent nucleosome assembly (GO:0006335)4.24515579
28DNA replication-dependent nucleosome organization (GO:0034723)4.24515579
29* chromosome condensation (GO:0030261)4.23608690
30regulation of DNA endoreduplication (GO:0032875)4.19492239
31telomere maintenance via recombination (GO:0000722)4.14168865
32mitotic recombination (GO:0006312)4.13435422
33* mitotic nuclear envelope disassembly (GO:0007077)4.06416576
34establishment of integrated proviral latency (GO:0075713)4.05097700
35regulation of mitotic spindle organization (GO:0060236)4.04182135
36regulation of centriole replication (GO:0046599)4.01521494
37nucleobase biosynthetic process (GO:0046112)4.01478329
38spindle checkpoint (GO:0031577)4.00738416
39histone exchange (GO:0043486)3.99762246
40maturation of SSU-rRNA (GO:0030490)3.95784605
41purine nucleobase biosynthetic process (GO:0009113)3.89967172
42nuclear pore organization (GO:0006999)3.85956811
43positive regulation of chromosome segregation (GO:0051984)3.81312592
44regulation of chromosome segregation (GO:0051983)3.78805337
45* DNA packaging (GO:0006323)3.77226009
46* membrane disassembly (GO:0030397)3.75917568
47* nuclear envelope disassembly (GO:0051081)3.75917568
48negative regulation of chromosome segregation (GO:0051985)3.74026922
49negative regulation of mitosis (GO:0045839)3.73639489
50spindle assembly checkpoint (GO:0071173)3.73114734
51ribosomal small subunit assembly (GO:0000028)3.72082439
52negative regulation of mitotic sister chromatid segregation (GO:0033048)3.71850045
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.71850045
54negative regulation of sister chromatid segregation (GO:0033046)3.71850045
55negative regulation of mitotic sister chromatid separation (GO:2000816)3.71850045
56formation of translation preinitiation complex (GO:0001731)3.71239999
57telomere maintenance via telomere lengthening (GO:0010833)3.68538195
58* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.67729726
59mitotic spindle assembly checkpoint (GO:0007094)3.65859302
60mitotic spindle checkpoint (GO:0071174)3.65580435
61DNA double-strand break processing (GO:0000729)3.64500796
62regulation of mitotic metaphase/anaphase transition (GO:0030071)3.63197504
63meiotic chromosome segregation (GO:0045132)3.61062902
64negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.60357699
65replication fork processing (GO:0031297)3.58922943
66nuclear pore complex assembly (GO:0051292)3.55225478
67chromosome segregation (GO:0007059)3.54546491
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.54513704
69viral transcription (GO:0019083)3.54251965
70microtubule polymerization or depolymerization (GO:0031109)3.53750956
71translational termination (GO:0006415)3.52584491
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.49036695
73ribosome assembly (GO:0042255)3.48384819
74regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.44819632
75regulation of mitotic sister chromatid separation (GO:0010965)3.43340568
76regulation of mitotic sister chromatid segregation (GO:0033047)3.43340568
77regulation of sister chromatid segregation (GO:0033045)3.43340568
78ribosomal large subunit biogenesis (GO:0042273)3.42815833
79resolution of meiotic recombination intermediates (GO:0000712)3.41313166
80maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.39404485
81ribosome biogenesis (GO:0042254)3.36621470
82pore complex assembly (GO:0046931)3.36134768
83spliceosomal snRNP assembly (GO:0000387)3.35361426
84mitotic spindle organization (GO:0007052)3.35292805
85ribonucleoprotein complex biogenesis (GO:0022613)3.33813637
86histone-serine phosphorylation (GO:0035404)3.33288173
87negative regulation of DNA-dependent DNA replication (GO:2000104)3.32772412
88chromatin assembly or disassembly (GO:0006333)3.32551074
89negative regulation of cell division (GO:0051782)3.32382247
90regulation of centrosome cycle (GO:0046605)3.31782764
91folic acid-containing compound biosynthetic process (GO:0009396)3.31597452
92IMP biosynthetic process (GO:0006188)3.30592087
93* protein localization to chromosome (GO:0034502)3.30468198
94double-strand break repair via nonhomologous end joining (GO:0006303)3.30387929
95non-recombinational repair (GO:0000726)3.30387929
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.30018835
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.30018835
98positive regulation of mitotic sister chromatid separation (GO:1901970)3.30018835
99ribosomal small subunit biogenesis (GO:0042274)3.29523459
100spindle assembly involved in mitosis (GO:0090307)3.27706015
101translational initiation (GO:0006413)3.27495726
102* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24230336
103centriole replication (GO:0007099)3.22856986
104regulation of double-strand break repair via homologous recombination (GO:0010569)3.22621540
105translational elongation (GO:0006414)3.20929091
106negative regulation of nuclear division (GO:0051784)3.20742901
107negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.19560970
108ATP-dependent chromatin remodeling (GO:0043044)3.16761995
109protein complex localization (GO:0031503)3.13405550
110regulation of centrosome duplication (GO:0010824)3.12570719
111deoxyribonucleotide biosynthetic process (GO:0009263)3.12495228
112rRNA processing (GO:0006364)3.11305716
113proteasome assembly (GO:0043248)3.11253798
114* mitotic cell cycle (GO:0000278)3.09381678
115protein K6-linked ubiquitination (GO:0085020)3.09360511
116nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.07195453
117regulation of sister chromatid cohesion (GO:0007063)3.06297476
118DNA deamination (GO:0045006)3.02667017
119spliceosomal complex assembly (GO:0000245)3.02372660
120transcription-coupled nucleotide-excision repair (GO:0006283)3.01828483
121* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01449151
122rRNA metabolic process (GO:0016072)3.00751538
123negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98231261
124* cell cycle G1/S phase transition (GO:0044843)2.96637669
125* G1/S transition of mitotic cell cycle (GO:0000082)2.96637669
126microtubule depolymerization (GO:0007019)2.96228662
127DNA duplex unwinding (GO:0032508)2.96005071
128DNA geometric change (GO:0032392)2.95991779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.95178324
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.94466838
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.31431763
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.17197661
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.91759962
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49247872
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20446949
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00788109
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.81168504
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76555779
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70307166
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70151446
13AR_21909140_ChIP-Seq_LNCAP_Human2.64144955
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.63280973
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.61222752
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51904000
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49739995
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41878410
19XRN2_22483619_ChIP-Seq_HELA_Human2.38440814
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34203306
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24166165
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.15132835
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.14180577
24VDR_23849224_ChIP-Seq_CD4+_Human2.07239096
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.98201623
26E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95466258
27* DCP1A_22483619_ChIP-Seq_HELA_Human1.90333103
28* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86408173
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84656677
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83878981
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83635676
32* FOXP3_21729870_ChIP-Seq_TREG_Human1.83071971
33TTF2_22483619_ChIP-Seq_HELA_Human1.80639589
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79031294
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78384850
36GABP_19822575_ChIP-Seq_HepG2_Human1.71712185
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66787858
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66342010
39ELK1_19687146_ChIP-ChIP_HELA_Human1.66169807
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65534244
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64532608
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63077474
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58195856
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50770926
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47379025
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46849073
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43531949
48CIITA_25753668_ChIP-Seq_RAJI_Human1.43179424
49KDM5A_27292631_Chip-Seq_BREAST_Human1.40595664
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39100877
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38850279
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38766142
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31482344
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30478494
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.29429125
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29236152
57MYC_22102868_ChIP-Seq_BL_Human1.27862324
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27489683
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27316371
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.25486145
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24578944
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22835982
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21575587
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21000532
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20894114
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20225615
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19209379
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17705177
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15084986
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.14125096
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13885387
72EWS_26573619_Chip-Seq_HEK293_Human1.13582323
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12071153
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08376871
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07103778
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03562375
77TFEB_21752829_ChIP-Seq_HELA_Human1.03125955
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02381462
79SOX2_16153702_ChIP-ChIP_HESCs_Human1.01504294
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00472675
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00001202
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97526742
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.97365705
84MYC_18940864_ChIP-ChIP_HL60_Human0.96370332
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94779232
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94018096
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91428064
88NANOG_21062744_ChIP-ChIP_HESCs_Human0.91184437
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89419143
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87828233
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87617233
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.86248262
93TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85676915
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85514256
95FUS_26573619_Chip-Seq_HEK293_Human0.84020034
96VDR_21846776_ChIP-Seq_THP-1_Human0.83334355
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83290797
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83050236
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.82446451
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81445878
101ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79861807
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79095546
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78633945
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78452303
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78190970
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77234535
107SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77150233
108SPI1_23547873_ChIP-Seq_NB4_Human0.76654836
109OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76274738
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.75261278
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.73029746
112TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70192491
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.65691334
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.65424766
115* CHD1_26751641_Chip-Seq_LNCaP_Human0.62664447
116FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.60538141
117IRF1_19129219_ChIP-ChIP_H3396_Human0.59164032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.92842666
2MP0003111_abnormal_nucleus_morphology5.03566382
3MP0010094_abnormal_chromosome_stability4.80173053
4MP0004957_abnormal_blastocyst_morpholog4.55966175
5MP0003077_abnormal_cell_cycle4.36937089
6MP0008057_abnormal_DNA_replication3.85878559
7MP0008007_abnormal_cellular_replicative3.18033014
8MP0008058_abnormal_DNA_repair3.06045410
9MP0008932_abnormal_embryonic_tissue2.88293292
10MP0003123_paternal_imprinting2.63449351
11MP0009697_abnormal_copulation2.63231902
12MP0001730_embryonic_growth_arrest2.48256954
13MP0000350_abnormal_cell_proliferation2.33228504
14MP0010307_abnormal_tumor_latency2.13515038
15MP0003786_premature_aging1.95324930
16MP0002396_abnormal_hematopoietic_system1.92225384
17MP0005380_embryogenesis_phenotype1.85482404
18MP0001672_abnormal_embryogenesis/_devel1.85482404
19MP0010352_gastrointestinal_tract_polyps1.83812774
20MP0001697_abnormal_embryo_size1.83013159
21MP0003718_maternal_effect1.76217659
22MP0010030_abnormal_orbit_morphology1.65938589
23* MP0002080_prenatal_lethality1.65751725
24MP0003984_embryonic_growth_retardation1.64361008
25MP0002085_abnormal_embryonic_tissue1.62649838
26MP0008877_abnormal_DNA_methylation1.61638945
27MP0002088_abnormal_embryonic_growth/wei1.60657959
28MP0000490_abnormal_crypts_of1.53009938
29MP0004808_abnormal_hematopoietic_stem1.48165006
30MP0003567_abnormal_fetal_cardiomyocyte1.46233577
31MP0002086_abnormal_extraembryonic_tissu1.46075366
32MP0002084_abnormal_developmental_patter1.42743274
33MP0005076_abnormal_cell_differentiation1.42321002
34MP0000313_abnormal_cell_death1.41479303
35MP0004197_abnormal_fetal_growth/weight/1.37676279
36MP0009053_abnormal_anal_canal1.34771375
37MP0002019_abnormal_tumor_incidence1.34729751
38MP0001346_abnormal_lacrimal_gland1.30910129
39MP0003315_abnormal_perineum_morphology1.30363016
40MP0003121_genomic_imprinting1.28008471
41MP0003136_yellow_coat_color1.25142274
42MP0001529_abnormal_vocalization1.23492076
43MP0000372_irregular_coat_pigmentation1.23239691
44MP0009333_abnormal_splenocyte_physiolog1.19434492
45MP0000537_abnormal_urethra_morphology1.16639314
46MP0001293_anophthalmia1.13151878
47* MP0002210_abnormal_sex_determination1.12898362
48MP0006054_spinal_hemorrhage1.10033077
49MP0003941_abnormal_skin_development1.07430516
50MP0005397_hematopoietic_system_phenotyp1.06027652
51MP0001545_abnormal_hematopoietic_system1.06027652
52MP0002234_abnormal_pharynx_morphology1.05711259
53MP0003705_abnormal_hypodermis_morpholog1.03011418
54MP0002233_abnormal_nose_morphology1.01689138
55* MP0001145_abnormal_male_reproductive1.01179474
56MP0005171_absent_coat_pigmentation1.00706628
57MP0003937_abnormal_limbs/digits/tail_de1.00239913
58MP0006072_abnormal_retinal_apoptosis0.97760890
59MP0006035_abnormal_mitochondrial_morpho0.95056741
60MP0005408_hypopigmentation0.94499933
61MP0003890_abnormal_embryonic-extraembry0.93401738
62MP0002009_preneoplasia0.91636899
63MP0002111_abnormal_tail_morphology0.90055471
64MP0009379_abnormal_foot_pigmentation0.89192697
65MP0008789_abnormal_olfactory_epithelium0.87204290
66MP0005248_abnormal_Harderian_gland0.86611417
67MP0003806_abnormal_nucleotide_metabolis0.86151633
68MP0000703_abnormal_thymus_morphology0.85336188
69MP0000647_abnormal_sebaceous_gland0.85298002
70* MP0001929_abnormal_gametogenesis0.84796153
71* MP0000653_abnormal_sex_gland0.84532058
72MP0003119_abnormal_digestive_system0.84383903
73MP0009672_abnormal_birth_weight0.83827461
74MP0000858_altered_metastatic_potential0.83364260
75MP0002160_abnormal_reproductive_system0.82350912
76MP0003385_abnormal_body_wall0.79995333
77MP0002877_abnormal_melanocyte_morpholog0.79548432
78MP0000428_abnormal_craniofacial_morphol0.78813805
79MP0003861_abnormal_nervous_system0.78707419
80MP0000358_abnormal_cell_content/0.77675170
81MP0005384_cellular_phenotype0.77476255
82MP0003566_abnormal_cell_adhesion0.77061702
83MP0005023_abnormal_wound_healing0.76990699
84MP0006292_abnormal_olfactory_placode0.76559501
85MP0006036_abnormal_mitochondrial_physio0.75772665
86MP0005621_abnormal_cell_physiology0.75736573
87MP0003221_abnormal_cardiomyocyte_apopto0.75335702
88MP0002722_abnormal_immune_system0.75099763
89MP0005391_vision/eye_phenotype0.74866119
90MP0002132_abnormal_respiratory_system0.72476117
91* MP0001119_abnormal_female_reproductive0.72316435
92MP0002398_abnormal_bone_marrow0.72309557
93MP0005395_other_phenotype0.71716167
94MP0005389_reproductive_system_phenotype0.71208678
95MP0002102_abnormal_ear_morphology0.70450194
96MP0001915_intracranial_hemorrhage0.69779803
97MP0000566_synostosis0.69606412
98MP0002092_abnormal_eye_morphology0.68690407
99MP0001286_abnormal_eye_development0.67001927
100MP0000689_abnormal_spleen_morphology0.66425479
101MP0003186_abnormal_redox_activity0.65468512
102MP0002938_white_spotting0.64730586
103MP0003943_abnormal_hepatobiliary_system0.64657600
104MP0000750_abnormal_muscle_regeneration0.64458498
105MP0009278_abnormal_bone_marrow0.64290319
106MP0003699_abnormal_female_reproductive0.63952132
107MP0002177_abnormal_outer_ear0.62827860
108MP0009703_decreased_birth_body0.61953744
109MP0009250_abnormal_appendicular_skeleto0.61352394
110MP0003115_abnormal_respiratory_system0.61326682
111MP0000733_abnormal_muscle_development0.61285257
112* MP0003698_abnormal_male_reproductive0.60218370
113MP0000432_abnormal_head_morphology0.58458755
114* MP0002161_abnormal_fertility/fecundity0.58291165
115MP0002429_abnormal_blood_cell0.57640150
116MP0002095_abnormal_skin_pigmentation0.57387361
117MP0004133_heterotaxia0.56721173
118MP0001727_abnormal_embryo_implantation0.55944415
119MP0005394_taste/olfaction_phenotype0.55030336
120MP0005499_abnormal_olfactory_system0.55030336
121MP0000477_abnormal_intestine_morphology0.53020695
122MP0003755_abnormal_palate_morphology0.52632269
123MP0003935_abnormal_craniofacial_develop0.52546779
124MP0003938_abnormal_ear_development0.51762117
125MP0001849_ear_inflammation0.51203327
126MP0002925_abnormal_cardiovascular_devel0.50832721
127MP0000049_abnormal_middle_ear0.50525168
128MP0002653_abnormal_ependyma_morphology0.50404331
129MP0003763_abnormal_thymus_physiology0.50132757
130MP0002697_abnormal_eye_size0.50105889
131MP0002932_abnormal_joint_morphology0.49865702

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.78985177
2Reticulocytopenia (HP:0001896)4.43475060
3Breast hypoplasia (HP:0003187)4.25664394
4Chromsome breakage (HP:0040012)4.14811454
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.07122903
6Cortical dysplasia (HP:0002539)3.99509622
7Patellar aplasia (HP:0006443)3.71959713
8Meckel diverticulum (HP:0002245)3.55039945
9Abnormality of cells of the erythroid lineage (HP:0012130)3.53618561
10Aplasia/Hypoplasia of the patella (HP:0006498)3.50859213
11Carpal bone hypoplasia (HP:0001498)3.48336650
12Selective tooth agenesis (HP:0001592)3.42679469
13Abnormality of chromosome stability (HP:0003220)3.39330397
14Abnormal number of erythroid precursors (HP:0012131)3.36951223
15Abnormality of the ileum (HP:0001549)3.34790485
16Colon cancer (HP:0003003)3.33425799
17Oral leukoplakia (HP:0002745)3.31947459
18Abnormality of the preputium (HP:0100587)3.26485753
19Impulsivity (HP:0100710)3.18469826
20Small intestinal stenosis (HP:0012848)3.13755783
21Duodenal stenosis (HP:0100867)3.13755783
22Aplasia/Hypoplasia of the uvula (HP:0010293)3.08395833
23Rough bone trabeculation (HP:0100670)3.08354538
24Degeneration of anterior horn cells (HP:0002398)3.01194428
25Abnormality of the anterior horn cell (HP:0006802)3.01194428
26Absent radius (HP:0003974)2.99276175
27Myelodysplasia (HP:0002863)2.78025907
28Absent forearm bone (HP:0003953)2.77756853
29Aplasia involving forearm bones (HP:0009822)2.77756853
30Abnormal lung lobation (HP:0002101)2.77290337
31Absent thumb (HP:0009777)2.75807855
32Medulloblastoma (HP:0002885)2.73555869
33Aplastic anemia (HP:0001915)2.71423043
34Abnormality of the fetal cardiovascular system (HP:0010948)2.69569187
35Abnormal umbilical cord blood vessels (HP:0011403)2.69569187
36Single umbilical artery (HP:0001195)2.69569187
37Macrocytic anemia (HP:0001972)2.68325046
38Abnormality of the labia minora (HP:0012880)2.61339550
39Ependymoma (HP:0002888)2.60332931
40Pallor (HP:0000980)2.58633389
41Abnormality of the duodenum (HP:0002246)2.53629355
42Neoplasm of the pancreas (HP:0002894)2.52753431
4311 pairs of ribs (HP:0000878)2.52638490
44Sloping forehead (HP:0000340)2.50213454
45Increased nuchal translucency (HP:0010880)2.49996980
46Embryonal neoplasm (HP:0002898)2.47538935
47Bone marrow hypocellularity (HP:0005528)2.46607152
48Multiple enchondromatosis (HP:0005701)2.42518964
49Hypoplasia of the capital femoral epiphysis (HP:0003090)2.40113269
50Abnormal number of incisors (HP:0011064)2.39731444
51Premature graying of hair (HP:0002216)2.39489563
52Horseshoe kidney (HP:0000085)2.38245407
53Trismus (HP:0000211)2.37591596
54Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.36978751
55Atresia of the external auditory canal (HP:0000413)2.36231228
56Tracheoesophageal fistula (HP:0002575)2.34634459
57Microretrognathia (HP:0000308)2.33652819
58Triphalangeal thumb (HP:0001199)2.32418901
59Hypoplastic pelvis (HP:0008839)2.32267956
60Ectopic kidney (HP:0000086)2.31999969
61Supernumerary spleens (HP:0009799)2.31545738
62Nephroblastoma (Wilms tumor) (HP:0002667)2.30559488
63Duplicated collecting system (HP:0000081)2.27404308
64Proximal placement of thumb (HP:0009623)2.27220410
65Cerebral hypomyelination (HP:0006808)2.26732177
66Rhabdomyosarcoma (HP:0002859)2.24413752
67Deviation of the thumb (HP:0009603)2.20965097
68Agnosia (HP:0010524)2.20758452
69Abnormal trabecular bone morphology (HP:0100671)2.19724967
70Arteriovenous malformation (HP:0100026)2.18816266
71Short thumb (HP:0009778)2.16514897
72Embryonal renal neoplasm (HP:0011794)2.16262728
73Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11221112
74Abnormality of the carotid arteries (HP:0005344)2.10862100
75Facial hemangioma (HP:0000329)2.10444922
76Cafe-au-lait spot (HP:0000957)2.09815617
77Ureteral duplication (HP:0000073)2.06999552
78Secondary amenorrhea (HP:0000869)2.04890031
79Slender long bone (HP:0003100)2.04741784
80Cleft eyelid (HP:0000625)2.01634736
81Abnormality of glycolysis (HP:0004366)2.00233954
82Cellular immunodeficiency (HP:0005374)1.97379640
83Squamous cell carcinoma (HP:0002860)1.95596827
84Neoplasm of the colon (HP:0100273)1.95453780
85Short 4th metacarpal (HP:0010044)1.95327268
86Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95327268
87Abnormality of the calcaneus (HP:0008364)1.95322982
88Pancreatic islet-cell hyperplasia (HP:0004510)1.95106214
89Aplasia/Hypoplasia of the sternum (HP:0006714)1.94900243
90Missing ribs (HP:0000921)1.94893038
91Abnormal auditory evoked potentials (HP:0006958)1.93970831
92Abnormality of the renal collecting system (HP:0004742)1.91622887
93Premature ovarian failure (HP:0008209)1.91047564
94High pitched voice (HP:0001620)1.91016259
95Abnormality of the umbilical cord (HP:0010881)1.90412490
96Oligodactyly (hands) (HP:0001180)1.90052076
97Glossoptosis (HP:0000162)1.89856104
98Glioma (HP:0009733)1.89406432
99Ovarian neoplasm (HP:0100615)1.89075377
100Ankle contracture (HP:0006466)1.88963087
101Increased serum pyruvate (HP:0003542)1.88606605
102Abnormality of chromosome segregation (HP:0002916)1.87410984
103Basal cell carcinoma (HP:0002671)1.86954149
104Duplication of thumb phalanx (HP:0009942)1.85713681
105Abnormality of reticulocytes (HP:0004312)1.85311844
106Clubbing of toes (HP:0100760)1.83480839
107Overlapping toe (HP:0001845)1.80969924
108Short middle phalanx of the 5th finger (HP:0004220)1.77451568
109Abnormality of abdominal situs (HP:0011620)1.75755016
110Abdominal situs inversus (HP:0003363)1.75755016
111Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75404439
112Absent epiphyses (HP:0010577)1.75404439
113Volvulus (HP:0002580)1.74866235
114Intestinal atresia (HP:0011100)1.73365939
115Prominent nose (HP:0000448)1.73106886
116Thrombocytosis (HP:0001894)1.72160841
117Deep philtrum (HP:0002002)1.71520500
118Choanal atresia (HP:0000453)1.71437986
119Aplasia/hypoplasia of the humerus (HP:0006507)1.71230826
120Long clavicles (HP:0000890)1.71110809
121Oligodactyly (HP:0012165)1.71063248
122Abnormality of methionine metabolism (HP:0010901)1.70116780
123Abnormality of the septum pellucidum (HP:0007375)1.69104006
124Absent septum pellucidum (HP:0001331)1.67546439
125Irregular epiphyses (HP:0010582)1.63111895
126Abnormalities of placenta or umbilical cord (HP:0001194)1.62441987
127Facial cleft (HP:0002006)1.61184323
128Abnormality of cochlea (HP:0000375)1.59816902
129Holoprosencephaly (HP:0001360)1.59581101
130Median cleft lip (HP:0000161)1.58915812
131Acute encephalopathy (HP:0006846)1.58107385
132Oligohydramnios (HP:0001562)1.56963407
133Septo-optic dysplasia (HP:0100842)1.56803755
134Aplasia/Hypoplasia of the earlobes (HP:0009906)1.55777146
135Hemivertebrae (HP:0002937)1.54950932
136Dandy-Walker malformation (HP:0001305)1.52513044
137Abnormality of the astrocytes (HP:0100707)1.52382773
138Astrocytoma (HP:0009592)1.52382773
139Renal agenesis (HP:0000104)1.52233857

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.15563247
2CDC73.90448144
3* WEE13.54681940
4NEK23.38459445
5EIF2AK13.21589291
6BRSK22.90429218
7NEK12.85282370
8TTK2.71043462
9SRPK12.53464792
10PLK12.35766948
11PLK42.27247472
12NME22.22092325
13TLK12.04585356
14BRSK12.04095319
15AURKB2.01872680
16VRK21.97571410
17TESK21.95689122
18ACVR1B1.94695200
19VRK11.85729589
20PLK31.83835578
21EIF2AK31.81201540
22MKNK11.79573655
23CCNB11.79311685
24TSSK61.77396050
25STK161.67983046
26DYRK31.51979600
27ATR1.51871161
28CHEK21.51251187
29TRIM281.50905310
30AURKA1.48469143
31RPS6KA41.47695857
32STK101.42285279
33MKNK21.40373445
34PASK1.38273276
35MST41.36539211
36TAF11.35872257
37STK41.34969318
38RPS6KB21.30912910
39CDK41.29641540
40ZAK1.26007032
41* CDK71.20768083
42PAK41.17138100
43* CHEK11.12171044
44* MAP3K81.08438964
45NUAK11.02258286
46EPHA21.01830178
47PBK0.96086800
48TNIK0.94741858
49TGFBR10.93548678
50ERBB30.90556061
51EEF2K0.90412643
52CDK120.90332077
53MELK0.89440314
54SCYL20.85531236
55TESK10.83046410
56ATM0.81602716
57STK30.81200261
58CDK20.79319460
59CDK60.78984089
60PAK10.78821338
61BCR0.74628563
62PLK20.74041440
63BRAF0.73912975
64PIM10.69541576
65LRRK20.67643577
66* CDK10.65601917
67LATS20.65303628
68NME10.64956981
69MAP3K100.64139560
70BMPR1B0.63546326
71CDK80.63405156
72PKN20.63188720
73WNK30.62394612
74ERBB40.60619978
75KDR0.59674892
76CLK10.59449665
77ALK0.58412364
78* CSNK2A10.57975493
79PIM20.57532021
80PDK20.56946637
81FLT30.53008144
82UHMK10.52251281
83* CSNK2A20.51048142
84STK38L0.50312017
85PNCK0.49128408
86MST1R0.48578627
87MAP3K110.48448167
88RPS6KA50.48287350
89* EIF2AK20.47983833
90PRKCI0.46717801
91MARK30.43913263
92MET0.42405074
93NEK90.40634766
94CDK30.39807428
95LIMK10.39143906
96ILK0.35503349
97AKT20.35254402
98SMG10.34324446
99FGFR10.31404006
100MAP2K30.30176519
101BRD40.29562193
102MINK10.29522451
103LATS10.28395844
104STK390.28156027
105PAK20.27658662
106PRKDC0.27269342
107PKN10.26941476
108CSNK1G10.25068839
109YES10.23952877
110TAOK20.23399696
111MAPK130.22202639
112ABL20.21971113
113MTOR0.21616489
114CSNK1E0.21562028
115RAF10.21299208
116DYRK20.21211729
117CDK11A0.20881931
118CSNK1G30.19911055
119CDK150.19108269
120MAPKAPK30.17790605
121KSR10.17087517
122CDK180.16876753
123MAPK140.16157220
124CDK140.15683606
125MAP3K30.15616482
126MAPKAPK20.14651326
127TTN0.14579116
128AKT10.13878655
129PDK30.13579835
130PDK40.13579835

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.05595312
2Mismatch repair_Homo sapiens_hsa034304.29931044
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56960181
4Ribosome_Homo sapiens_hsa030103.42503611
5Spliceosome_Homo sapiens_hsa030403.38866583
6RNA polymerase_Homo sapiens_hsa030203.24186014
7Homologous recombination_Homo sapiens_hsa034403.22340455
8RNA transport_Homo sapiens_hsa030133.21072334
9* Cell cycle_Homo sapiens_hsa041103.18788135
10Base excision repair_Homo sapiens_hsa034103.08431198
11Proteasome_Homo sapiens_hsa030503.06163235
12Nucleotide excision repair_Homo sapiens_hsa034202.96146439
13One carbon pool by folate_Homo sapiens_hsa006702.57554504
14Pyrimidine metabolism_Homo sapiens_hsa002402.48628158
15Fanconi anemia pathway_Homo sapiens_hsa034602.45616885
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13655015
17Basal transcription factors_Homo sapiens_hsa030221.90766830
18Non-homologous end-joining_Homo sapiens_hsa034501.88612556
19RNA degradation_Homo sapiens_hsa030181.80109168
20* p53 signaling pathway_Homo sapiens_hsa041151.78077086
21mRNA surveillance pathway_Homo sapiens_hsa030151.69659998
22Systemic lupus erythematosus_Homo sapiens_hsa053221.61071088
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39341760
24Pyruvate metabolism_Homo sapiens_hsa006201.32161161
25Purine metabolism_Homo sapiens_hsa002301.28945764
26* Oocyte meiosis_Homo sapiens_hsa041141.24674952
27Vitamin B6 metabolism_Homo sapiens_hsa007501.21204160
28Steroid biosynthesis_Homo sapiens_hsa001001.18196738
29Propanoate metabolism_Homo sapiens_hsa006401.17616738
30* Epstein-Barr virus infection_Homo sapiens_hsa051691.16950579
31* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10855307
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07234310
33* Viral carcinogenesis_Homo sapiens_hsa052031.03047298
34Fatty acid elongation_Homo sapiens_hsa000621.00602118
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99724159
36Oxidative phosphorylation_Homo sapiens_hsa001900.96250220
37Pentose phosphate pathway_Homo sapiens_hsa000300.90152342
38Biosynthesis of amino acids_Homo sapiens_hsa012300.83344731
39HTLV-I infection_Homo sapiens_hsa051660.81413078
40* Herpes simplex infection_Homo sapiens_hsa051680.80905243
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78477193
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78454366
43Antigen processing and presentation_Homo sapiens_hsa046120.78021196
44Small cell lung cancer_Homo sapiens_hsa052220.77324900
45MicroRNAs in cancer_Homo sapiens_hsa052060.76143522
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75826237
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.73953703
48Folate biosynthesis_Homo sapiens_hsa007900.73947062
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70030352
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.67299717
51Selenocompound metabolism_Homo sapiens_hsa004500.66107222
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63246945
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.61903063
54Alcoholism_Homo sapiens_hsa050340.59123292
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57777036
56Thyroid cancer_Homo sapiens_hsa052160.55818387
57Protein export_Homo sapiens_hsa030600.53338918
58Glutathione metabolism_Homo sapiens_hsa004800.52704459
59Alzheimers disease_Homo sapiens_hsa050100.51940937
60Hippo signaling pathway_Homo sapiens_hsa043900.50795514
61TGF-beta signaling pathway_Homo sapiens_hsa043500.50515270
62Legionellosis_Homo sapiens_hsa051340.50167300
63Apoptosis_Homo sapiens_hsa042100.47629795
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47078485
65Lysine degradation_Homo sapiens_hsa003100.46539970
66Basal cell carcinoma_Homo sapiens_hsa052170.45072126
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43926922
68Carbon metabolism_Homo sapiens_hsa012000.43537769
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43358284
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43172976
71Fatty acid metabolism_Homo sapiens_hsa012120.43010406
72Huntingtons disease_Homo sapiens_hsa050160.42757245
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42551646
74Wnt signaling pathway_Homo sapiens_hsa043100.41852822
75Bladder cancer_Homo sapiens_hsa052190.41033702
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40520572
77Sulfur relay system_Homo sapiens_hsa041220.39347270
78Colorectal cancer_Homo sapiens_hsa052100.37863999
79Hepatitis B_Homo sapiens_hsa051610.37618272
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35859393
81Shigellosis_Homo sapiens_hsa051310.33904533
82N-Glycan biosynthesis_Homo sapiens_hsa005100.31951744
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31006865
84HIF-1 signaling pathway_Homo sapiens_hsa040660.30188990
85Chronic myeloid leukemia_Homo sapiens_hsa052200.29729982
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29553855
87Hedgehog signaling pathway_Homo sapiens_hsa043400.29442323
88Pathways in cancer_Homo sapiens_hsa052000.27354415
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26715667
90Measles_Homo sapiens_hsa051620.25045024
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24903448
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23991707
93Fructose and mannose metabolism_Homo sapiens_hsa000510.23870210
94Adherens junction_Homo sapiens_hsa045200.23829315
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21348157
96Viral myocarditis_Homo sapiens_hsa054160.21010692
97Arginine and proline metabolism_Homo sapiens_hsa003300.20402133
98Renin-angiotensin system_Homo sapiens_hsa046140.20012282
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.19206910
100Notch signaling pathway_Homo sapiens_hsa043300.19091814
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19052704
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18886710
103Sulfur metabolism_Homo sapiens_hsa009200.18462937
104Influenza A_Homo sapiens_hsa051640.18302680
105Prostate cancer_Homo sapiens_hsa052150.18129883
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.17407891
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17038692
108Primary immunodeficiency_Homo sapiens_hsa053400.15523554
109Galactose metabolism_Homo sapiens_hsa000520.14798133
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14483511
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14091894
112Metabolic pathways_Homo sapiens_hsa011000.13818121
113Hematopoietic cell lineage_Homo sapiens_hsa046400.13577087
114Parkinsons disease_Homo sapiens_hsa050120.13170565
115FoxO signaling pathway_Homo sapiens_hsa040680.12475726
116Melanoma_Homo sapiens_hsa052180.11791180
117Vitamin digestion and absorption_Homo sapiens_hsa049770.11748360
118Tight junction_Homo sapiens_hsa045300.11583528
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11079798
120Proteoglycans in cancer_Homo sapiens_hsa052050.10973776
121Butanoate metabolism_Homo sapiens_hsa006500.10382266
122mTOR signaling pathway_Homo sapiens_hsa041500.10312947
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.09153235
124Fatty acid degradation_Homo sapiens_hsa000710.08695484
125Peroxisome_Homo sapiens_hsa041460.06883381
126Tyrosine metabolism_Homo sapiens_hsa003500.01654131

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