CDK11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)6.79668885
2acrosome reaction (GO:0007340)6.56027624
3fusion of sperm to egg plasma membrane (GO:0007342)6.26987388
4sperm capacitation (GO:0048240)5.70444463
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.53899241
6phosphatidylethanolamine biosynthetic process (GO:0006646)5.29510592
7phosphatidylethanolamine metabolic process (GO:0046337)4.82684224
8spermatid development (GO:0007286)4.70449373
9DNA packaging (GO:0006323)4.68508602
10protein targeting to Golgi (GO:0000042)4.62183542
11plasma membrane fusion (GO:0045026)4.55045028
12chromosome condensation (GO:0030261)4.51818530
13establishment of protein localization to Golgi (GO:0072600)4.45017067
14spermatid nucleus differentiation (GO:0007289)4.38641466
15positive regulation of gamma-delta T cell activation (GO:0046645)4.36326481
16retrograde transport, vesicle recycling within Golgi (GO:0000301)4.31536740
17single strand break repair (GO:0000012)4.25000254
18RNA destabilization (GO:0050779)4.06592819
19centriole replication (GO:0007099)4.02356357
20regulation of gamma-delta T cell activation (GO:0046643)4.00444146
21rRNA methylation (GO:0031167)4.00279882
22regulation of T-helper 2 cell differentiation (GO:0045628)3.98789954
23multicellular organism reproduction (GO:0032504)3.98640223
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.97166095
25negative regulation of cell killing (GO:0031342)3.97166095
26regulation of gamma-delta T cell differentiation (GO:0045586)3.96392268
27regulation of Rab GTPase activity (GO:0032313)3.95721841
28positive regulation of Rab GTPase activity (GO:0032851)3.95721841
29negative regulation of inclusion body assembly (GO:0090084)3.91728072
30sexual reproduction (GO:0019953)3.83132944
31reproduction (GO:0000003)3.80827835
32microtubule depolymerization (GO:0007019)3.75506180
33sperm-egg recognition (GO:0035036)3.72830045
34cell wall macromolecule catabolic process (GO:0016998)3.61620401
35centriole assembly (GO:0098534)3.53412136
36protein polyglutamylation (GO:0018095)3.46685900
37mast cell degranulation (GO:0043303)3.45803530
38mast cell activation involved in immune response (GO:0002279)3.45803530
39regulation of histone H3-K27 methylation (GO:0061085)3.43935793
40cell wall macromolecule metabolic process (GO:0044036)3.39877830
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.39205413
42cell-cell recognition (GO:0009988)3.37857168
43negative thymic T cell selection (GO:0045060)3.35070294
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.34699966
45mast cell activation (GO:0045576)3.34218194
46response to pheromone (GO:0019236)3.31562894
47regulation of B cell receptor signaling pathway (GO:0050855)3.31170305
48regulation of ARF GTPase activity (GO:0032312)3.28907755
49negative T cell selection (GO:0043383)3.27727484
50histone H3-K36 demethylation (GO:0070544)3.27120043
51tolerance induction (GO:0002507)3.26583571
52rRNA modification (GO:0000154)3.24874333
53antigen processing and presentation of endogenous antigen (GO:0019883)3.21676849
54positive regulation of type 2 immune response (GO:0002830)3.21660817
55microtubule severing (GO:0051013)3.20598406
56protein localization to Golgi apparatus (GO:0034067)3.19614466
57leukocyte aggregation (GO:0070486)3.18071020
58calcium ion-dependent exocytosis (GO:0017156)3.16625925
59histone H3-K9 demethylation (GO:0033169)3.16174259
60spermatogenesis (GO:0007283)3.14846314
61male gamete generation (GO:0048232)3.13757155
62chromatin silencing (GO:0006342)3.11621137
63antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.11203176
64cellular extravasation (GO:0045123)3.10504043
65negative regulation of histone methylation (GO:0031061)3.09271925
66positive thymic T cell selection (GO:0045059)3.08343488
67positive regulation of histone deacetylation (GO:0031065)3.05131655
68regulation of transcription involved in cell fate commitment (GO:0060850)3.02941479
69negative regulation of erythrocyte differentiation (GO:0045647)2.99605786
70leukocyte degranulation (GO:0043299)2.99218411
71regulation of granulocyte differentiation (GO:0030852)2.98710948
72cilium or flagellum-dependent cell motility (GO:0001539)2.98224512
73positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.96583143
74positive regulation of granulocyte differentiation (GO:0030854)2.93978839
75binding of sperm to zona pellucida (GO:0007339)2.93617263
76positive regulation of T cell mediated cytotoxicity (GO:0001916)2.93105113
77positive T cell selection (GO:0043368)2.93058147
78thymic T cell selection (GO:0045061)2.90555008
79microtubule polymerization or depolymerization (GO:0031109)2.88298321
80T cell selection (GO:0045058)2.87304960
81histone H4 deacetylation (GO:0070933)2.86621659
82NIK/NF-kappaB signaling (GO:0038061)2.86520264
83myeloid cell activation involved in immune response (GO:0002275)2.85394481
84defense response to protozoan (GO:0042832)2.84816018
85response to muramyl dipeptide (GO:0032495)2.83491604
86gamete generation (GO:0007276)2.83292338
87negative regulation of granulocyte differentiation (GO:0030853)2.83065091
88positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.82912711
89regulation of T cell mediated cytotoxicity (GO:0001914)2.82669409
90macrophage activation involved in immune response (GO:0002281)2.81330149
91regulation of cilium movement (GO:0003352)2.79950251
92response to type I interferon (GO:0034340)2.78726129
93immunoglobulin mediated immune response (GO:0016064)2.78513437
94type I interferon signaling pathway (GO:0060337)2.77804295
95cellular response to type I interferon (GO:0071357)2.77804295
96regulation of regulatory T cell differentiation (GO:0045589)2.73355544
97germinal center formation (GO:0002467)2.73276585
98T cell migration (GO:0072678)2.72855807
99modulation by symbiont of host immune response (GO:0052553)2.71371810
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71371810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.62429365
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.09927895
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.91997366
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.90119325
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58879193
6ELF1_20517297_ChIP-Seq_JURKAT_Human2.44884555
7RUNX_20019798_ChIP-Seq_JUKART_Human2.42272936
8VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.26581615
9BCL6_27268052_Chip-Seq_Bcells_Human2.25764173
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.22157499
11VDR_21846776_ChIP-Seq_THP-1_Human2.21404239
12* MAF_26560356_Chip-Seq_TH2_Human2.19074728
13E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.18649815
14* MAF_26560356_Chip-Seq_TH1_Human2.15552147
15LXR_22292898_ChIP-Seq_THP-1_Human2.11258302
16BCOR_27268052_Chip-Seq_Bcells_Human2.10875002
17MYB_26560356_Chip-Seq_TH2_Human2.10046001
18P68_20966046_ChIP-Seq_HELA_Human2.09513833
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07866752
20* UTX_26944678_Chip-Seq_JUKART_Human2.05369724
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.03500668
22MYC_22102868_ChIP-Seq_BL_Human2.02013838
23SPI1_23127762_ChIP-Seq_K562_Human2.01166592
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01024957
25* MYB_26560356_Chip-Seq_TH1_Human1.97377208
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95851328
27VDR_24763502_ChIP-Seq_THP-1_Human1.94745844
28TCF7_22412390_ChIP-Seq_EML_Mouse1.94324406
29SCL_19346495_ChIP-Seq_HPC-7_Human1.92011112
30EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.91528065
31E2F1_20622854_ChIP-Seq_HELA_Human1.84414296
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83779347
33* PHF8_20622854_ChIP-Seq_HELA_Human1.73964106
34KDM2B_26808549_Chip-Seq_DND41_Human1.73923980
35RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.69508360
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69341649
37SMC4_20622854_ChIP-Seq_HELA_Human1.69104532
38* P300_27268052_Chip-Seq_Bcells_Human1.66253088
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65173009
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64310085
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63846873
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62896467
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62888234
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62284231
45RAC3_21632823_ChIP-Seq_H3396_Human1.56711769
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.55909868
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55836530
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54374372
49GATA3_27048872_Chip-Seq_THYMUS_Human1.54220928
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.53430827
51SPI1_23547873_ChIP-Seq_NB4_Human1.53000089
52SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.51642653
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48667685
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.48040693
55GATA1_19941826_ChIP-Seq_K562_Human1.47484309
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46812701
57ERA_21632823_ChIP-Seq_H3396_Human1.46645716
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44703505
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41938598
60* SA1_27219007_Chip-Seq_ERYTHROID_Human1.41366263
61* SA1_27219007_Chip-Seq_Bcells_Human1.37536105
62P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.35604106
63* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33557260
64DROSHA_22980978_ChIP-Seq_HELA_Human1.33015448
65NCOR1_26117541_ChIP-Seq_K562_Human1.32592094
66CTCF_20526341_ChIP-Seq_ESCs_Human1.30992495
67VDR_24787735_ChIP-Seq_THP-1_Human1.30740921
68STAT1_20625510_ChIP-Seq_HELA_Human1.30545378
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29918456
70SPI1_20517297_ChIP-Seq_HL60_Human1.29003330
71NANOG_20526341_ChIP-Seq_ESCs_Human1.28243376
72STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26727773
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25828107
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25163314
75OCT4_19829295_ChIP-Seq_ESCs_Human1.21134699
76TP63_22573176_ChIP-Seq_HFKS_Human1.21088219
77TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20057304
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.19542812
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17747517
80* ELK3_25401928_ChIP-Seq_HUVEC_Human1.17340783
81* CTCF_27219007_Chip-Seq_Bcells_Human1.16682179
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15423325
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12885018
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10826757
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09518448
86CTCF_21964334_Chip-Seq_Bcells_Human1.09458562
87OCT4_20526341_ChIP-Seq_ESCs_Human1.07624198
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07619956
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07254938
90GATA3_26560356_Chip-Seq_TH2_Human1.06841544
91TAF2_19829295_ChIP-Seq_ESCs_Human1.04745774
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04658854
93FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04425971
94CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03593490
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03197526
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.03042544
97FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02995650
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.02963258
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02863737
100CEBPB_22108803_ChIP-Seq_LS180_Human1.02657392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.37362581
2MP0003436_decreased_susceptibility_to3.25569910
3MP0001835_abnormal_antigen_presentation3.22916337
4MP0005451_abnormal_body_composition2.89236188
5MP0005670_abnormal_white_adipose2.88030072
6MP0005671_abnormal_response_to2.67666531
7MP0001800_abnormal_humoral_immune2.61805511
8MP0003878_abnormal_ear_physiology2.46477032
9MP0005377_hearing/vestibular/ear_phenot2.46477032
10MP0003303_peritoneal_inflammation2.46130567
11MP0000685_abnormal_immune_system2.41661086
12MP0005387_immune_system_phenotype2.35990807
13MP0001790_abnormal_immune_system2.35990807
14MP0003698_abnormal_male_reproductive2.35166325
15MP0003763_abnormal_thymus_physiology2.31234322
16MP0003724_increased_susceptibility_to2.30988396
17MP0005025_abnormal_response_to2.30836155
18MP0005000_abnormal_immune_tolerance2.29213667
19MP0002723_abnormal_immune_serum2.28449354
20MP0009785_altered_susceptibility_to2.24129925
21MP0001929_abnormal_gametogenesis2.15938937
22MP0002419_abnormal_innate_immunity2.13770430
23MP0002452_abnormal_antigen_presenting2.13332244
24MP0001873_stomach_inflammation2.13071183
25MP0002420_abnormal_adaptive_immunity2.10224990
26MP0001819_abnormal_immune_cell2.08218939
27MP0005310_abnormal_salivary_gland2.02381897
28MP0003172_abnormal_lysosome_physiology2.01244351
29MP0002398_abnormal_bone_marrow1.87582537
30MP0001348_abnormal_lacrimal_gland1.86947402
31MP0002132_abnormal_respiratory_system1.82564787
32MP0000678_abnormal_parathyroid_gland1.82188474
33MP0009278_abnormal_bone_marrow1.77651839
34MP0009333_abnormal_splenocyte_physiolog1.77342343
35MP0000716_abnormal_immune_system1.72481247
36MP0006082_CNS_inflammation1.68421589
37MP0002148_abnormal_hypersensitivity_rea1.66839951
38MP0000703_abnormal_thymus_morphology1.62374102
39MP0002405_respiratory_system_inflammati1.60798437
40MP0002722_abnormal_immune_system1.56703526
41MP0005397_hematopoietic_system_phenotyp1.54148268
42MP0001545_abnormal_hematopoietic_system1.54148268
43MP0004947_skin_inflammation1.53311192
44MP0001533_abnormal_skeleton_physiology1.46249773
45MP0000689_abnormal_spleen_morphology1.43068828
46MP0008995_early_reproductive_senescence1.42148128
47MP0002429_abnormal_blood_cell1.41856228
48MP0010155_abnormal_intestine_physiology1.34956631
49MP0002822_catalepsy1.33468276
50MP0001845_abnormal_inflammatory_respons1.30300485
51MP0001853_heart_inflammation1.29357754
52MP0009764_decreased_sensitivity_to1.26618842
53MP0004510_myositis1.26121515
54MP0002161_abnormal_fertility/fecundity1.24730237
55MP0003300_gastrointestinal_ulcer1.23997504
56MP0008469_abnormal_protein_level1.20902227
57MP0002396_abnormal_hematopoietic_system1.20372267
58MP0002138_abnormal_hepatobiliary_system1.17869446
59MP0008260_abnormal_autophagy1.16830107
60MP0001986_abnormal_taste_sensitivity1.11667433
61MP0003866_abnormal_defecation1.11028106
62MP0002210_abnormal_sex_determination1.10431150
63MP0002933_joint_inflammation1.04604582
64MP0003646_muscle_fatigue1.03963897
65MP0005464_abnormal_platelet_physiology0.97555201
66MP0002166_altered_tumor_susceptibility0.95866478
67MP0001765_abnormal_ion_homeostasis0.94973673
68MP0008961_abnormal_basal_metabolism0.93534935
69MP0009115_abnormal_fat_cell0.91278551
70MP0005666_abnormal_adipose_tissue0.88729375
71MP0003656_abnormal_erythrocyte_physiolo0.87756491
72MP0002254_reproductive_system_inflammat0.84275850
73MP0008877_abnormal_DNA_methylation0.83075285
74MP0002998_abnormal_bone_remodeling0.82836073
75MP0001145_abnormal_male_reproductive0.81865932
76MP0005166_decreased_susceptibility_to0.75593748
77MP0004808_abnormal_hematopoietic_stem0.75044571
78MP0000249_abnormal_blood_vessel0.73946382
79MP0000653_abnormal_sex_gland0.73745032
80MP0004381_abnormal_hair_follicle0.71818603
81MP0005535_abnormal_body_temperature0.71690105
82MP0005058_abnormal_lysosome_morphology0.71159095
83MP0000313_abnormal_cell_death0.70140435
84MP0003786_premature_aging0.68267768
85MP0003693_abnormal_embryo_hatching0.66234461
86MP0000609_abnormal_liver_physiology0.66210158
87MP0002019_abnormal_tumor_incidence0.65821135
88MP0009765_abnormal_xenobiotic_induced0.64934080
89MP0003828_pulmonary_edema0.63774752
90MP0005083_abnormal_biliary_tract0.61565311
91MP0005375_adipose_tissue_phenotype0.61056423
92MP0002693_abnormal_pancreas_physiology0.60435728
93MP0003077_abnormal_cell_cycle0.56544785
94MP0001663_abnormal_digestive_system0.56269620
95MP0003448_altered_tumor_morphology0.55826603
96MP0010307_abnormal_tumor_latency0.55509356
97MP0004742_abnormal_vestibular_system0.54518614
98MP0005334_abnormal_fat_pad0.54167171
99MP0005164_abnormal_response_to0.53499044
100MP0001851_eye_inflammation0.53266571

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)6.13702353
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.10224063
3Eczematoid dermatitis (HP:0000976)4.12978377
4Gastrointestinal infarctions (HP:0005244)4.01558673
5Stomatitis (HP:0010280)3.82161490
6Recurrent bacterial skin infections (HP:0005406)3.65357933
7Abnormality of macrophages (HP:0004311)3.49534042
8Recurrent abscess formation (HP:0002722)3.48709071
9Myositis (HP:0100614)3.47665447
10Asymmetric septal hypertrophy (HP:0001670)3.45608711
11Obstructive lung disease (HP:0006536)3.45242249
12Chronic obstructive pulmonary disease (HP:0006510)3.45242249
13Recurrent fungal infections (HP:0002841)3.35116973
14Enlarged epiphyses (HP:0010580)3.33462688
15Impulsivity (HP:0100710)3.30835392
16Gingivitis (HP:0000230)3.19996643
17Elevated erythrocyte sedimentation rate (HP:0003565)3.18916281
18Retrobulbar optic neuritis (HP:0100654)3.13387747
19Optic neuritis (HP:0100653)3.13387747
20Hypoplasia of the thymus (HP:0000778)3.13096738
21Attenuation of retinal blood vessels (HP:0007843)3.08836661
22Meningitis (HP:0001287)3.03061187
23Nasal polyposis (HP:0100582)3.02834930
24Bony spicule pigmentary retinopathy (HP:0007737)3.01388389
25Orchitis (HP:0100796)3.00234474
26Hypochromic microcytic anemia (HP:0004840)2.94562033
27Pustule (HP:0200039)2.94297790
28Abnormal rod and cone electroretinograms (HP:0008323)2.93884129
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.92014869
30Resting tremor (HP:0002322)2.85649460
31Mediastinal lymphadenopathy (HP:0100721)2.76764535
32Abnormality of T cell physiology (HP:0011840)2.76583219
33Hyperkalemia (HP:0002153)2.73236701
34Panhypogammaglobulinemia (HP:0003139)2.72505474
35Aplasia/Hypoplasia of the earlobes (HP:0009906)2.72503877
36Abnormality of T cells (HP:0002843)2.71433447
37Colitis (HP:0002583)2.68024822
38Hypochromic anemia (HP:0001931)2.66718186
39Inflammation of the large intestine (HP:0002037)2.65072042
40Gastrointestinal inflammation (HP:0004386)2.63241198
41Recurrent cutaneous fungal infections (HP:0011370)2.63200726
42Chronic mucocutaneous candidiasis (HP:0002728)2.63200726
43Bell-shaped thorax (HP:0001591)2.63180791
44Recurrent skin infections (HP:0001581)2.61610369
45Vasculitis (HP:0002633)2.59715608
46Slow saccadic eye movements (HP:0000514)2.58407118
47Encephalitis (HP:0002383)2.56338183
48Abnormality of the nasal mucosa (HP:0000433)2.54145486
49Male infertility (HP:0003251)2.53491673
50Aplasia/Hypoplasia of the thymus (HP:0010515)2.51563217
51Chest pain (HP:0100749)2.48454740
52Hypoplastic ischia (HP:0003175)2.46278570
53Abnormality of the fingertips (HP:0001211)2.43531995
54Granulocytopenia (HP:0001913)2.42954007
55Pulmonary infiltrates (HP:0002113)2.42449045
56Prolonged bleeding time (HP:0003010)2.40847619
57Increased IgE level (HP:0003212)2.39552039
58Seborrheic dermatitis (HP:0001051)2.39469291
59Abnormal spermatogenesis (HP:0008669)2.39035350
60Recurrent gram-negative bacterial infections (HP:0005420)2.38929223
61Hemoptysis (HP:0002105)2.36335952
62Leukocytosis (HP:0001974)2.36303693
63Recurrent pneumonia (HP:0006532)2.33403627
64T lymphocytopenia (HP:0005403)2.30661456
65Tetany (HP:0001281)2.29973118
66Recurrent viral infections (HP:0004429)2.26137679
67Azoospermia (HP:0000027)2.24449378
68Abnormality of T cell number (HP:0011839)2.23236924
69Abnormality of macular pigmentation (HP:0008002)2.21772839
70Tubulointerstitial nephritis (HP:0001970)2.20363316
71Fatigue (HP:0012378)2.18932605
72Postural instability (HP:0002172)2.18324719
73Truncal obesity (HP:0001956)2.17222766
74Hypertensive crisis (HP:0100735)2.16748159
75Dynein arm defect of respiratory motile cilia (HP:0012255)2.16383011
76Absent/shortened dynein arms (HP:0200106)2.16383011
77Keratoconjunctivitis sicca (HP:0001097)2.11821591
78Hypertriglyceridemia (HP:0002155)2.10943895
79Cellulitis (HP:0100658)2.06159981
80Agammaglobulinemia (HP:0004432)2.04973208
81Keratoconjunctivitis (HP:0001096)2.03678525
82Infertility (HP:0000789)1.99347070
83Chronic hepatic failure (HP:0100626)1.98474599
84Widely patent fontanelles and sutures (HP:0004492)1.97784491
85Facial shape deformation (HP:0011334)1.97638834
86Potter facies (HP:0002009)1.97638834
87Malnutrition (HP:0004395)1.93818193
88Cone-rod dystrophy (HP:0000548)1.92885558
89Supernumerary ribs (HP:0005815)1.90280212
90Peritonitis (HP:0002586)1.89399836
91Supernumerary bones of the axial skeleton (HP:0009144)1.88644611
92Severe combined immunodeficiency (HP:0004430)1.87723263
93Abnormality of DNA repair (HP:0003254)1.87109297
94Autoimmune hemolytic anemia (HP:0001890)1.86504640
95Lymphopenia (HP:0001888)1.84480476
96Abnormality of the peritoneum (HP:0002585)1.83268743
97Chronic diarrhea (HP:0002028)1.81711269
98Epistaxis (HP:0000421)1.80834030
99Recurrent bronchitis (HP:0002837)1.80702134
100Abnormality of the costochondral junction (HP:0000919)1.79985561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.15053186
2PLK43.94404439
3RIPK43.67300259
4TESK13.04855294
5CDK122.39641957
6DDR22.33002796
7TXK2.09319923
8JAK32.07426485
9MAPK152.06130181
10TNK22.02499330
11BRD42.00996651
12TAOK31.99866944
13STK381.94572411
14ERN11.92943853
15BLK1.90159964
16TYK21.86842604
17SIK21.86768348
18MAP3K111.71094577
19ZAP701.66440382
20GRK61.63004949
21PNCK1.60775868
22IKBKE1.59679731
23CAMK1G1.57792522
24PRPF4B1.57225786
25IKBKB1.55731467
26CSK1.52567353
27FES1.48466410
28IRAK41.45976205
29MAP3K131.40204735
30ITK1.39702695
31MAP2K31.38334957
32MAP3K141.34576195
33PDK11.31744506
34BTK1.29588835
35MAP4K21.26275484
36TBK11.26270449
37PDPK11.25045790
38TESK21.17641581
39SYK1.16517411
40MAP3K11.16179294
41MARK31.15649835
42TAOK11.08641368
43CAMK1D1.06323101
44TEC0.97124869
45KIT0.96721529
46PIK3CG0.95394320
47HCK0.95005527
48PRKD30.93281434
49PTK2B0.93087864
50MST1R0.92630490
51LYN0.90658826
52CHUK0.89685987
53PASK0.89181556
54LCK0.88562164
55BMPR20.87146024
56SIK30.86677438
57MAP3K30.86324769
58MATK0.85601960
59CDK40.84132743
60JAK20.82863253
61MAP2K20.81145985
62CSF1R0.80993406
63MARK20.76472139
64CDK70.74084553
65DYRK1B0.74025786
66TRIB30.73147229
67CDC42BPA0.71239987
68WNK10.70844026
69JAK10.70792974
70RPS6KA10.65913489
71FGFR40.63190724
72RPS6KL10.62792275
73RPS6KC10.62792275
74MAPK110.62676792
75FGR0.59163395
76IRAK10.58658197
77PRKCQ0.56895734
78RPS6KA60.55658654
79IRAK20.55343254
80INSRR0.50986498
81PRKAA20.50797055
82KSR20.50682609
83HIPK20.50201437
84EPHB10.49791790
85WNK40.47894334
86MTOR0.47665021
87NEK60.47192783
88RPS6KA20.46935132
89SIK10.46121082
90MAPK80.45850018
91TAOK20.44377207
92NME10.43325453
93PIM10.42594420
94TYRO30.42501168
95MAPK10.42146935
96AKT30.42061189
97PTK60.40106920
98PRKG20.38271405
99MAP3K80.38078870
100MAP2K60.37730250

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.51435911
2Graft-versus-host disease_Homo sapiens_hsa053323.23476596
3Autoimmune thyroid disease_Homo sapiens_hsa053203.22943255
4Primary immunodeficiency_Homo sapiens_hsa053402.71740540
5Type I diabetes mellitus_Homo sapiens_hsa049402.63111249
6Fatty acid biosynthesis_Homo sapiens_hsa000612.40888138
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.36960910
8Leishmaniasis_Homo sapiens_hsa051402.36623770
9Asthma_Homo sapiens_hsa053102.25967581
10Osteoclast differentiation_Homo sapiens_hsa043802.19052596
11Antigen processing and presentation_Homo sapiens_hsa046122.14626249
12B cell receptor signaling pathway_Homo sapiens_hsa046622.10969090
13T cell receptor signaling pathway_Homo sapiens_hsa046602.06564401
14Acute myeloid leukemia_Homo sapiens_hsa052212.04933893
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04569389
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.91433550
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.84352671
18Staphylococcus aureus infection_Homo sapiens_hsa051501.79634935
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.73598873
20Influenza A_Homo sapiens_hsa051641.69428014
21Herpes simplex infection_Homo sapiens_hsa051681.65401521
22Measles_Homo sapiens_hsa051621.64952738
23Viral myocarditis_Homo sapiens_hsa054161.55735134
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55595329
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.53023748
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52030109
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49770667
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46770511
29Hematopoietic cell lineage_Homo sapiens_hsa046401.43412912
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42568168
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42113303
32Tuberculosis_Homo sapiens_hsa051521.41073238
33Toxoplasmosis_Homo sapiens_hsa051451.40701204
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.40020527
35Other glycan degradation_Homo sapiens_hsa005111.32359979
36Chemokine signaling pathway_Homo sapiens_hsa040621.27582510
37TNF signaling pathway_Homo sapiens_hsa046681.25948190
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23550393
39Legionellosis_Homo sapiens_hsa051341.05927445
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.05910256
41Dorso-ventral axis formation_Homo sapiens_hsa043201.04084803
42Malaria_Homo sapiens_hsa051441.03882625
43Epstein-Barr virus infection_Homo sapiens_hsa051691.01736387
44VEGF signaling pathway_Homo sapiens_hsa043700.95725023
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91389234
46Prolactin signaling pathway_Homo sapiens_hsa049170.90027274
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87713955
48African trypanosomiasis_Homo sapiens_hsa051430.87445568
49Olfactory transduction_Homo sapiens_hsa047400.87041691
50Hepatitis B_Homo sapiens_hsa051610.86558452
51Type II diabetes mellitus_Homo sapiens_hsa049300.86113370
52Rheumatoid arthritis_Homo sapiens_hsa053230.84591952
53Endocytosis_Homo sapiens_hsa041440.81264027
54Viral carcinogenesis_Homo sapiens_hsa052030.80299266
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78691380
56Non-small cell lung cancer_Homo sapiens_hsa052230.78665967
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76736736
58Inositol phosphate metabolism_Homo sapiens_hsa005620.75943213
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71100299
60Regulation of autophagy_Homo sapiens_hsa041400.70933509
61Apoptosis_Homo sapiens_hsa042100.66235817
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63004022
63Platelet activation_Homo sapiens_hsa046110.62872653
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62560133
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62116885
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61685536
67mTOR signaling pathway_Homo sapiens_hsa041500.59791865
68MAPK signaling pathway_Homo sapiens_hsa040100.57112867
69HTLV-I infection_Homo sapiens_hsa051660.56615816
70Notch signaling pathway_Homo sapiens_hsa043300.56290697
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55962821
72Hepatitis C_Homo sapiens_hsa051600.52180590
73Pertussis_Homo sapiens_hsa051330.51767720
74Choline metabolism in cancer_Homo sapiens_hsa052310.51184170
75Spliceosome_Homo sapiens_hsa030400.50906540
76Insulin resistance_Homo sapiens_hsa049310.50241926
77ABC transporters_Homo sapiens_hsa020100.47517240
78Basal transcription factors_Homo sapiens_hsa030220.46575603
79Chronic myeloid leukemia_Homo sapiens_hsa052200.46451988
80Homologous recombination_Homo sapiens_hsa034400.46161002
81mRNA surveillance pathway_Homo sapiens_hsa030150.44570769
82RNA transport_Homo sapiens_hsa030130.41298248
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.40583546
84Phagosome_Homo sapiens_hsa041450.40134767
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.39813735
86HIF-1 signaling pathway_Homo sapiens_hsa040660.39294608
87Renal cell carcinoma_Homo sapiens_hsa052110.38246986
88FoxO signaling pathway_Homo sapiens_hsa040680.38133457
89Estrogen signaling pathway_Homo sapiens_hsa049150.38085013
90Glycerolipid metabolism_Homo sapiens_hsa005610.37678740
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34764674
92Pancreatic cancer_Homo sapiens_hsa052120.33923866
93Shigellosis_Homo sapiens_hsa051310.33690297
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.30191878
95Prostate cancer_Homo sapiens_hsa052150.29673859
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.29234354
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28301448
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25861846
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.24906960
100Lysosome_Homo sapiens_hsa041420.22166838

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