CDK11B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.68243408
2positive thymic T cell selection (GO:0045059)4.47792189
3negative regulation of cell killing (GO:0031342)4.33634934
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.33634934
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.22232178
6histone H3-K4 trimethylation (GO:0080182)3.89137918
7chromosome condensation (GO:0030261)3.84631032
8positive regulation of gamma-delta T cell activation (GO:0046645)3.81454181
9histone H3-K9 demethylation (GO:0033169)3.81423735
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.75507962
11signal complex assembly (GO:0007172)3.73509578
12positive T cell selection (GO:0043368)3.69124592
13regulation of NFAT protein import into nucleus (GO:0051532)3.65793612
14regulation of gamma-delta T cell differentiation (GO:0045586)3.56422683
15positive regulation of histone deacetylation (GO:0031065)3.53720891
16histone H4 deacetylation (GO:0070933)3.53045723
17positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.45666095
18DNA packaging (GO:0006323)3.45493420
19regulation of ARF GTPase activity (GO:0032312)3.43674790
20regulation of histone H3-K27 methylation (GO:0061085)3.41237264
21poly(A)+ mRNA export from nucleus (GO:0016973)3.40588616
22positive regulation of Cdc42 GTPase activity (GO:0043089)3.39889806
23maturation of SSU-rRNA (GO:0030490)3.29493953
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.27970281
25regulation of gamma-delta T cell activation (GO:0046643)3.27712183
26mitotic chromosome condensation (GO:0007076)3.19345326
27thymic T cell selection (GO:0045061)3.16722268
28interferon-gamma production (GO:0032609)3.16237405
29intracellular estrogen receptor signaling pathway (GO:0030520)3.15219979
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13301757
31histone H3-K4 methylation (GO:0051568)3.08290531
32modulation by virus of host process (GO:0019054)3.07400656
33negative regulation of histone methylation (GO:0031061)3.06548560
34positive regulation of gene expression, epigenetic (GO:0045815)3.05538885
35apoptotic process involved in morphogenesis (GO:0060561)3.05474525
36regulation of type I interferon-mediated signaling pathway (GO:0060338)3.04781680
37regulation of nucleobase-containing compound transport (GO:0032239)3.03405918
38pre-miRNA processing (GO:0031054)3.03192035
39negative T cell selection (GO:0043383)3.02479124
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01696622
41positive regulation by organism of defense response of other organism involved in symbiotic interact3.01696622
42modulation by symbiont of host immune response (GO:0052553)3.01696622
43positive regulation by symbiont of host defense response (GO:0052509)3.01696622
44modulation by symbiont of host defense response (GO:0052031)3.01696622
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01696622
46mitotic sister chromatid cohesion (GO:0007064)2.99603010
47regulation of T-helper 2 cell differentiation (GO:0045628)2.99098702
48negative thymic T cell selection (GO:0045060)2.96311856
49positive regulation of protein deacetylation (GO:0090312)2.95872831
50histone lysine demethylation (GO:0070076)2.92973292
51mannose metabolic process (GO:0006013)2.92563233
52response to muramyl dipeptide (GO:0032495)2.91283565
53antigen processing and presentation of endogenous antigen (GO:0019883)2.89768484
54positive regulation of myotube differentiation (GO:0010831)2.89095669
55modulation by symbiont of host cellular process (GO:0044068)2.89056758
56kinetochore organization (GO:0051383)2.88938387
57negative regulation of cell size (GO:0045792)2.88664954
58histone demethylation (GO:0016577)2.87150526
59histone H3 deacetylation (GO:0070932)2.84767744
60spliceosomal tri-snRNP complex assembly (GO:0000244)2.84732424
61regulation of T cell tolerance induction (GO:0002664)2.82587734
62regulation of early endosome to late endosome transport (GO:2000641)2.81122113
63germinal center formation (GO:0002467)2.77661645
64negative regulation of inclusion body assembly (GO:0090084)2.76563486
65sexual reproduction (GO:0019953)2.76414806
66cellular response to virus (GO:0098586)2.75688750
67maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75349425
68T cell selection (GO:0045058)2.72740458
69kinetochore assembly (GO:0051382)2.70161913
70tolerance induction (GO:0002507)2.67735107
71positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.67417273
72nucleosome disassembly (GO:0006337)2.62971831
73protein-DNA complex disassembly (GO:0032986)2.62971831
74regulation of chromatin binding (GO:0035561)2.61984768
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.61491608
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.61491608
77positive regulation of mitotic sister chromatid separation (GO:1901970)2.61491608
78mature B cell differentiation (GO:0002335)2.61023346
79leukocyte aggregation (GO:0070486)2.60929310
80megakaryocyte development (GO:0035855)2.59639007
81response to peptidoglycan (GO:0032494)2.59470022
82regulation of defense response to virus by virus (GO:0050690)2.59205058
83peptidyl-lysine trimethylation (GO:0018023)2.58633429
84protein dealkylation (GO:0008214)2.58501450
85protein demethylation (GO:0006482)2.58501450
86antigen processing and presentation via MHC class Ib (GO:0002475)2.56288676
87replication fork processing (GO:0031297)2.55770217
88NIK/NF-kappaB signaling (GO:0038061)2.55491744
89activation of MAPKKK activity (GO:0000185)2.53481052
90regulation of B cell receptor signaling pathway (GO:0050855)2.53476736
91histone H3-K36 demethylation (GO:0070544)2.53450821
92activation of Rac GTPase activity (GO:0032863)2.52189357
93chromatin silencing (GO:0006342)2.50624688
94regulation of ARF protein signal transduction (GO:0032012)2.49702942
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.48676253
96sperm capacitation (GO:0048240)2.48528487
97inner cell mass cell proliferation (GO:0001833)2.48501852
98trophectodermal cell differentiation (GO:0001829)2.48495425
99regulation of leukocyte degranulation (GO:0043300)2.47208124
100protein localization to endosome (GO:0036010)2.46887624
101alternative mRNA splicing, via spliceosome (GO:0000380)2.45538918
102regulation of interferon-beta biosynthetic process (GO:0045357)2.45399294
103stress fiber assembly (GO:0043149)2.45359765
104histone H4-K12 acetylation (GO:0043983)2.44965864
105macrophage activation involved in immune response (GO:0002281)2.43068618
106negative regulation of granulocyte differentiation (GO:0030853)2.42779322
107regulation of histone H3-K4 methylation (GO:0051569)2.42240383
108negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.41611608
109regulation of RNA export from nucleus (GO:0046831)2.41576521
110regulation of necroptotic process (GO:0060544)2.41384905
111regulation of mast cell degranulation (GO:0043304)2.41323623
112negative regulation of toll-like receptor signaling pathway (GO:0034122)2.41204854
113lipopolysaccharide-mediated signaling pathway (GO:0031663)2.41079053
114barbed-end actin filament capping (GO:0051016)2.40815357
115negative regulation of necroptotic process (GO:0060546)2.39699545
116face development (GO:0060324)2.39501765
117negative regulation of mRNA processing (GO:0050686)2.39128644
118mature B cell differentiation involved in immune response (GO:0002313)2.38979467
119nuclear pore complex assembly (GO:0051292)2.37129641
1203-UTR-mediated mRNA stabilization (GO:0070935)2.35899525
121response to type I interferon (GO:0034340)2.35306859
122regulation of nuclear cell cycle DNA replication (GO:0033262)2.34525444
123RNA splicing, via transesterification reactions (GO:0000375)2.34134632
124regulation of tolerance induction (GO:0002643)2.33894867
125histone mRNA catabolic process (GO:0071044)2.32843768
126B cell receptor signaling pathway (GO:0050853)2.31892361
127focal adhesion assembly (GO:0048041)2.31573162
128cell-substrate adherens junction assembly (GO:0007045)2.31573162
129mRNA splicing, via spliceosome (GO:0000398)2.31503433
130RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.31503433
131positive regulation of chromosome segregation (GO:0051984)2.31009733
132mRNA export from nucleus (GO:0006406)2.30504147
133retinoic acid receptor signaling pathway (GO:0048384)2.30125037
134positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.29679270
135regulation of posttranscriptional gene silencing (GO:0060147)2.29526714
136regulation of gene silencing by miRNA (GO:0060964)2.29526714
137regulation of gene silencing by RNA (GO:0060966)2.29526714
138type I interferon signaling pathway (GO:0060337)2.29339721
139cellular response to type I interferon (GO:0071357)2.29339721
140positive regulation of DNA-templated transcription, elongation (GO:0032786)2.28927477
141metaphase plate congression (GO:0051310)2.27551286
142negative regulation of RNA splicing (GO:0033119)2.27321368
143histone lysine methylation (GO:0034968)2.26736410
144regulation of B cell differentiation (GO:0045577)2.26585888
145telomere maintenance via telomerase (GO:0007004)2.26406678
146mitotic metaphase plate congression (GO:0007080)2.26060298
147negative regulation by host of viral transcription (GO:0043922)2.24719078
148somatic hypermutation of immunoglobulin genes (GO:0016446)2.24350350
149somatic diversification of immune receptors via somatic mutation (GO:0002566)2.24350350
150DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.23185703
151cellular extravasation (GO:0045123)2.22248907
152histone H3-K9 methylation (GO:0051567)2.22076466
153negative regulation of DNA-dependent DNA replication (GO:2000104)2.21827163
154regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.20566106
155protein localization to chromosome, centromeric region (GO:0071459)2.20110290
156definitive hemopoiesis (GO:0060216)2.19858187
157telomere maintenance via recombination (GO:0000722)2.19804121
158T cell migration (GO:0072678)2.19728002
159protein localization to kinetochore (GO:0034501)2.18925189
160viral mRNA export from host cell nucleus (GO:0046784)2.18888257
161T cell receptor signaling pathway (GO:0050852)2.18800711
162mast cell degranulation (GO:0043303)2.18389603
163mast cell activation involved in immune response (GO:0002279)2.18389603
164intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.17793658
165regulation of T cell receptor signaling pathway (GO:0050856)2.17098935
166B cell mediated immunity (GO:0019724)2.16955107
167termination of RNA polymerase II transcription (GO:0006369)2.16920250
168intra-S DNA damage checkpoint (GO:0031573)2.16603519
169RNA export from nucleus (GO:0006405)2.16245539
170formation of translation preinitiation complex (GO:0001731)2.15960460
171regulation of sister chromatid cohesion (GO:0007063)2.15942737
172meiotic chromosome segregation (GO:0045132)2.15441898
173telomere maintenance via semi-conservative replication (GO:0032201)2.13681845
174nuclear pore organization (GO:0006999)2.13070995
175ribosomal small subunit biogenesis (GO:0042274)2.12955967
176telomere maintenance via telomere lengthening (GO:0010833)2.12849399
177ribosome biogenesis (GO:0042254)2.10882985
178immunoglobulin mediated immune response (GO:0016064)2.10836744
179mRNA stabilization (GO:0048255)2.10257639
180RNA stabilization (GO:0043489)2.10257639
181regulation of interleukin-12 biosynthetic process (GO:0045075)2.10122878
182negative regulation of T cell mediated immunity (GO:0002710)2.09611983
183antigen receptor-mediated signaling pathway (GO:0050851)2.08827608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.38691293
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.43758426
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.42120811
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21795158
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.19726497
6MYC_22102868_ChIP-Seq_BL_Human2.92317126
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.88423202
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.77594996
9LXR_22292898_ChIP-Seq_THP-1_Human2.70612954
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59789351
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.44322486
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.43997859
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.42491970
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37128929
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25947812
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22729451
17VDR_21846776_ChIP-Seq_THP-1_Human2.19234955
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13086241
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06740823
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.02813456
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98246748
22CIITA_25753668_ChIP-Seq_RAJI_Human1.96064942
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.93148654
24MYB_26560356_Chip-Seq_TH1_Human1.90919469
25* P68_20966046_ChIP-Seq_HELA_Human1.90742529
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89237923
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88699337
28MYB_26560356_Chip-Seq_TH2_Human1.88049871
29RACK7_27058665_Chip-Seq_MCF-7_Human1.87020046
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85226996
31MAF_26560356_Chip-Seq_TH1_Human1.82763033
32SCL_19346495_ChIP-Seq_HPC-7_Human1.82628161
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81374167
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78902676
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78902676
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78902676
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76284811
38* SPI1_23547873_ChIP-Seq_NB4_Human1.76175771
39TCF7_22412390_ChIP-Seq_EML_Mouse1.75514345
40UTX_26944678_Chip-Seq_JUKART_Human1.71910302
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67116673
42* ELF1_20517297_ChIP-Seq_JURKAT_Human1.66903386
43TET1_21451524_ChIP-Seq_MESCs_Mouse1.64446069
44SMC4_20622854_ChIP-Seq_HELA_Human1.63986325
45KDM2B_26808549_Chip-Seq_K562_Human1.63130074
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.62620658
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.61450346
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60893204
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58638384
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.54939286
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50903421
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50229269
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48852846
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48747705
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48184977
56BCOR_27268052_Chip-Seq_Bcells_Human1.46951473
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46948104
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.46821144
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.46632180
60BCL6_27268052_Chip-Seq_Bcells_Human1.44475615
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43797906
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40438258
63KDM2B_26808549_Chip-Seq_DND41_Human1.39204614
64VDR_23849224_ChIP-Seq_CD4+_Human1.38958654
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38295817
66* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37879955
67RUNX_20019798_ChIP-Seq_JUKART_Human1.37330885
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36476822
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34824226
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34470755
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.32863221
72MAF_26560356_Chip-Seq_TH2_Human1.31615591
73CREB1_26743006_Chip-Seq_LNCaP_Human1.30998273
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30245435
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29487496
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29150829
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.29145851
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28628228
79VDR_24763502_ChIP-Seq_THP-1_Human1.28530583
80FOXP3_21729870_ChIP-Seq_TREG_Human1.27153050
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26875387
82PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25730831
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25680551
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24656989
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24162739
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23849992
87GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23597267
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22907221
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21956586
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21569970
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21014175
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20491123
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20235197
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19295178
95* PHF8_20622854_ChIP-Seq_HELA_Human1.18787035
96E2F1_20622854_ChIP-Seq_HELA_Human1.18303084
97SA1_27219007_Chip-Seq_Bcells_Human1.18262675
98CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17970964
99CTCF_27219007_Chip-Seq_Bcells_Human1.17925506
100NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17129865
101NCOR1_26117541_ChIP-Seq_K562_Human1.16394741
102* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16166981
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15811141
104KDM5A_27292631_Chip-Seq_BREAST_Human1.15531117
105SALL1_21062744_ChIP-ChIP_HESCs_Human1.15512579
106ELK3_25401928_ChIP-Seq_HUVEC_Human1.15442565
107MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15029857
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14842030
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14626707
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13992004
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13567119
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13337148
113ATF3_27146783_Chip-Seq_COLON_Human1.12702194
114ELK1_19687146_ChIP-ChIP_HELA_Human1.12639635
115YY1_22570637_ChIP-Seq_MALME-3M_Human1.12208700
116CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12057400
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12001157
118XRN2_22483619_ChIP-Seq_HELA_Human1.11262662
119BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11260077
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10252682
121YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09657836
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08470317
123ETS1_20019798_ChIP-Seq_JURKAT_Human1.07892753
124SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07610794
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07550372
126IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06964790
127IRF8_27001747_Chip-Seq_BMDM_Mouse1.06513025
128ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04565076
129EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04424140
130ETS1_21867929_ChIP-Seq_TH2_Mouse1.04147946
131NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04088966
132* TTF2_22483619_ChIP-Seq_HELA_Human1.03454845
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03358616
134CTCF_21964334_Chip-Seq_Bcells_Human1.03086018
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02524515
136CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02139366
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01206250
138RUNX1_27514584_Chip-Seq_MCF-7_Human1.00762871
139* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00626270
140PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00441859
141MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00165979
142RARA_24833708_ChIP-Seq_LIVER_Mouse1.00162449
143CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99328607
144RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99227098
145TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98836979
146* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98666346
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97237908
148MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94783131
149TFEB_21752829_ChIP-Seq_HELA_Human0.94707555
150* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94431365
151KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94189388
152SMAD_19615063_ChIP-ChIP_OVARY_Human0.91715415
153SPI1_23127762_ChIP-Seq_K562_Human0.89372078
154KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88714530
155STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88701188
156SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88079269
157CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86095163
158KDM2B_26808549_Chip-Seq_JURKAT_Human0.83721460
159GATA3_27048872_Chip-Seq_THYMUS_Human0.83688092
160MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.81266369
161HIF1A_21447827_ChIP-Seq_MCF-7_Human0.81134613

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.98246321
2MP0008057_abnormal_DNA_replication3.33095109
3MP0003705_abnormal_hypodermis_morpholog3.14510274
4MP0000678_abnormal_parathyroid_gland2.94883906
5MP0002396_abnormal_hematopoietic_system2.84312760
6MP0003763_abnormal_thymus_physiology2.74433410
7* MP0003693_abnormal_embryo_hatching2.59223646
8MP0003111_abnormal_nucleus_morphology2.53720545
9MP0003077_abnormal_cell_cycle2.42908480
10MP0008058_abnormal_DNA_repair2.24429916
11MP0010094_abnormal_chromosome_stability2.16943809
12MP0004957_abnormal_blastocyst_morpholog2.10769652
13MP0004185_abnormal_adipocyte_glucose2.05332809
14MP0008260_abnormal_autophagy2.03728252
15MP0009278_abnormal_bone_marrow1.99912408
16MP0008877_abnormal_DNA_methylation1.98777045
17MP0008007_abnormal_cellular_replicative1.94905397
18MP0005058_abnormal_lysosome_morphology1.91907876
19MP0003172_abnormal_lysosome_physiology1.89720750
20MP0000703_abnormal_thymus_morphology1.88657215
21MP0001800_abnormal_humoral_immune1.87716489
22MP0005409_darkened_coat_color1.86904876
23MP0005671_abnormal_response_to1.85852370
24MP0003300_gastrointestinal_ulcer1.84115470
25MP0001348_abnormal_lacrimal_gland1.81676904
26MP0002405_respiratory_system_inflammati1.81175355
27MP0002398_abnormal_bone_marrow1.78339225
28MP0009333_abnormal_splenocyte_physiolog1.75607871
29MP0005666_abnormal_adipose_tissue1.75043038
30MP0003453_abnormal_keratinocyte_physiol1.73998965
31MP0004510_myositis1.71426727
32MP0000685_abnormal_immune_system1.70728272
33MP0005410_abnormal_fertilization1.68193219
34MP0004808_abnormal_hematopoietic_stem1.63605419
35MP0004858_abnormal_nervous_system1.63314095
36MP0010352_gastrointestinal_tract_polyps1.62553776
37MP0002420_abnormal_adaptive_immunity1.61978144
38MP0002009_preneoplasia1.61820078
39MP0005387_immune_system_phenotype1.60582433
40MP0001790_abnormal_immune_system1.60582433
41MP0001819_abnormal_immune_cell1.60516042
42MP0002452_abnormal_antigen_presenting1.57867080
43MP0003787_abnormal_imprinting1.56024232
44MP0002723_abnormal_immune_serum1.52362968
45MP0003828_pulmonary_edema1.48824714
46MP0001835_abnormal_antigen_presentation1.48738081
47MP0000716_abnormal_immune_system1.48584614
48MP0002877_abnormal_melanocyte_morpholog1.48192337
49MP0002722_abnormal_immune_system1.47813680
50MP0005000_abnormal_immune_tolerance1.47249781
51MP0000490_abnormal_crypts_of1.44257504
52MP0005375_adipose_tissue_phenotype1.44174707
53MP0001545_abnormal_hematopoietic_system1.42951496
54MP0005397_hematopoietic_system_phenotyp1.42951496
55MP0002249_abnormal_larynx_morphology1.42908093
56MP0003436_decreased_susceptibility_to1.42360513
57MP0009379_abnormal_foot_pigmentation1.41606205
58MP0005174_abnormal_tail_pigmentation1.40390656
59MP0004233_abnormal_muscle_weight1.39055553
60MP0005670_abnormal_white_adipose1.38536787
61MP0000689_abnormal_spleen_morphology1.35664921
62MP0006292_abnormal_olfactory_placode1.35170744
63MP0005380_embryogenesis_phenotype1.34684780
64MP0001672_abnormal_embryogenesis/_devel1.34684780
65MP0002166_altered_tumor_susceptibility1.32153896
66MP0009840_abnormal_foam_cell1.30627998
67* MP0001730_embryonic_growth_arrest1.30147719
68MP0003567_abnormal_fetal_cardiomyocyte1.29695822
69* MP0000350_abnormal_cell_proliferation1.29338714
70MP0002429_abnormal_blood_cell1.27349522
71MP0003984_embryonic_growth_retardation1.26381278
72MP0002006_tumorigenesis1.24631600
73MP0005025_abnormal_response_to1.23858281
74MP0002088_abnormal_embryonic_growth/wei1.23009577
75MP0002796_impaired_skin_barrier1.22638690
76MP0000858_altered_metastatic_potential1.21310885
77MP0001851_eye_inflammation1.21286039
78MP0004264_abnormal_extraembryonic_tissu1.19142010
79MP0001533_abnormal_skeleton_physiology1.19090575
80MP0002277_abnormal_respiratory_mucosa1.19049789
81MP0005076_abnormal_cell_differentiation1.17607017
82MP0003448_altered_tumor_morphology1.16754464
83MP0003866_abnormal_defecation1.15578123
84MP0001853_heart_inflammation1.14378247
85MP0010155_abnormal_intestine_physiology1.13267559
86MP0009785_altered_susceptibility_to1.12304460
87MP0003091_abnormal_cell_migration1.10578461
88MP0010307_abnormal_tumor_latency1.10431901
89MP0002084_abnormal_developmental_patter1.09883711
90MP0005501_abnormal_skin_physiology1.07773597
91MP0002086_abnormal_extraembryonic_tissu1.06996977
92* MP0002019_abnormal_tumor_incidence1.06815554
93MP0003136_yellow_coat_color1.06090212
94MP0000733_abnormal_muscle_development1.05579559
95MP0001697_abnormal_embryo_size1.05389081
96MP0002148_abnormal_hypersensitivity_rea1.04711544
97MP0008932_abnormal_embryonic_tissue1.04477542
98MP0000003_abnormal_adipose_tissue1.04293723
99MP0002089_abnormal_postnatal_growth/wei1.03827408
100MP0004947_skin_inflammation1.02716986
101MP0002419_abnormal_innate_immunity1.02117089
102MP0002132_abnormal_respiratory_system1.01681112
103MP0002085_abnormal_embryonic_tissue1.01454118
104MP0005310_abnormal_salivary_gland1.01358428
105MP0002998_abnormal_bone_remodeling1.00023031
106MP0003786_premature_aging0.99784751
107* MP0000313_abnormal_cell_death0.99672924
108MP0005075_abnormal_melanosome_morpholog0.96315419
109MP0008961_abnormal_basal_metabolism0.96034038
110MP0002933_joint_inflammation0.95219748
111MP0002925_abnormal_cardiovascular_devel0.93457512
112MP0003045_fibrosis0.93062139
113MP0003566_abnormal_cell_adhesion0.91770433
114MP0001873_stomach_inflammation0.91039599
115MP0008995_early_reproductive_senescence0.90957917
116MP0004197_abnormal_fetal_growth/weight/0.86224845
117MP0005464_abnormal_platelet_physiology0.85614635
118MP0002163_abnormal_gland_morphology0.85040282
119MP0003329_amyloid_beta_deposits0.85026243
120MP0000751_myopathy0.84540095
121MP0000747_muscle_weakness0.84019029
122* MP0002080_prenatal_lethality0.83403191
123MP0000015_abnormal_ear_pigmentation0.82754399
124MP0000465_gastrointestinal_hemorrhage0.82615375
125MP0001784_abnormal_fluid_regulation0.82108257
126MP0000759_abnormal_skeletal_muscle0.82054861
127MP0005621_abnormal_cell_physiology0.81977050
128MP0003941_abnormal_skin_development0.81273653
129MP0008469_abnormal_protein_level0.79678892
130MP0003698_abnormal_male_reproductive0.78609226
131MP0002970_abnormal_white_adipose0.77414778
132MP0001663_abnormal_digestive_system0.77025845
133MP0005166_decreased_susceptibility_to0.75746989
134MP0009931_abnormal_skin_appearance0.75225069
135MP0003303_peritoneal_inflammation0.75153363
136MP0001845_abnormal_inflammatory_respons0.75023149
137MP0004381_abnormal_hair_follicle0.72839382
138MP0001849_ear_inflammation0.71928220
139MP0003646_muscle_fatigue0.71466514
140MP0010234_abnormal_vibrissa_follicle0.71307450
141MP0001929_abnormal_gametogenesis0.70786100
142MP0004087_abnormal_muscle_fiber0.69846174
143MP0003890_abnormal_embryonic-extraembry0.69488807
144MP0005023_abnormal_wound_healing0.69373428
145MP0000432_abnormal_head_morphology0.69358205
146MP0010630_abnormal_cardiac_muscle0.69159106

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)3.56765478
2Chromsome breakage (HP:0040012)3.53497547
3Abnormality of the fingertips (HP:0001211)3.52856508
4Hyperacusis (HP:0010780)3.48168374
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.43401546
6Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.15913341
7Anal stenosis (HP:0002025)2.90641749
8T lymphocytopenia (HP:0005403)2.89174175
9Aplastic anemia (HP:0001915)2.89076175
10Abnormality of T cell number (HP:0011839)2.86378560
11Distal lower limb amyotrophy (HP:0008944)2.85291984
12Increased connective tissue (HP:0009025)2.80813989
13Rib fusion (HP:0000902)2.66525727
14Centrally nucleated skeletal muscle fibers (HP:0003687)2.58798596
15Thin bony cortex (HP:0002753)2.57248109
16Volvulus (HP:0002580)2.55092740
17Segmental peripheral demyelination/remyelination (HP:0003481)2.51743463
18Urethral obstruction (HP:0000796)2.50952098
19Myopathic facies (HP:0002058)2.50206415
20Abnormality of macrophages (HP:0004311)2.44235573
21Medulloblastoma (HP:0002885)2.41797195
22Severe combined immunodeficiency (HP:0004430)2.40440054
23Autoimmune hemolytic anemia (HP:0001890)2.35825776
24Intestinal atresia (HP:0011100)2.35673751
25Cerebral aneurysm (HP:0004944)2.35458714
26Metaphyseal cupping (HP:0003021)2.35100235
27Recurrent fungal infections (HP:0002841)2.34302488
28Lip pit (HP:0100267)2.33160172
29Increased IgE level (HP:0003212)2.32086217
30Slow saccadic eye movements (HP:0000514)2.31346424
31Aplasia cutis congenita (HP:0001057)2.29690948
32Deep palmar crease (HP:0006191)2.28882859
33Broad face (HP:0000283)2.28796412
34IgM deficiency (HP:0002850)2.28345333
35Abnormality of eosinophils (HP:0001879)2.28067002
36Recurrent bacterial skin infections (HP:0005406)2.26898977
37Disproportionate tall stature (HP:0001519)2.25518969
38Gastrointestinal inflammation (HP:0004386)2.23845886
39Long palpebral fissure (HP:0000637)2.23664485
40Myelodysplasia (HP:0002863)2.22773948
41Abnormality of the preputium (HP:0100587)2.22168799
42Abnormality of T cells (HP:0002843)2.21456500
43Gingivitis (HP:0000230)2.20837915
44Intestinal fistula (HP:0100819)2.20334337
45Hypertensive crisis (HP:0100735)2.20219639
46Asymmetric septal hypertrophy (HP:0001670)2.20016704
47Proximal placement of thumb (HP:0009623)2.19680109
48Polygenic inheritance (HP:0010982)2.19284074
49Deviation of the thumb (HP:0009603)2.17619439
50Insomnia (HP:0100785)2.16669530
51Lymphopenia (HP:0001888)2.16201425
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.14999188
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.14081688
54Prostate neoplasm (HP:0100787)2.13956409
55Supernumerary ribs (HP:0005815)2.13346298
56Acute myeloid leukemia (HP:0004808)2.11477244
57Esophageal atresia (HP:0002032)2.11446115
58Easy fatigability (HP:0003388)2.11402285
59Combined immunodeficiency (HP:0005387)2.11174287
60Natal tooth (HP:0000695)2.11045186
61Hemorrhage of the eye (HP:0011885)2.10111408
62Gastrointestinal infarctions (HP:0005244)2.08597239
63Achilles tendon contracture (HP:0001771)2.08441429
64Reticulocytosis (HP:0001923)2.08011832
65Ectopic kidney (HP:0000086)2.07473150
66Abnormal number of incisors (HP:0011064)2.07369354
67Sparse scalp hair (HP:0002209)2.07179579
68Autoimmune thrombocytopenia (HP:0001973)2.07126085
69Thyroiditis (HP:0100646)2.06590405
70Emphysema (HP:0002097)2.06397766
71Lymphoma (HP:0002665)2.04975570
72Recurrent viral infections (HP:0004429)2.04548715
73Lower limb amyotrophy (HP:0007210)2.04049361
74Ulnar bowing (HP:0003031)2.03419885
75Eczematoid dermatitis (HP:0000976)2.03176301
76Asplenia (HP:0001746)2.02751144
77Bowel incontinence (HP:0002607)2.00875407
78Distal upper limb amyotrophy (HP:0007149)2.00438709
79Upper limb amyotrophy (HP:0009129)2.00438709
80Seborrheic dermatitis (HP:0001051)2.00434319
81Atelectasis (HP:0100750)1.99699676
82Colitis (HP:0002583)1.99600321
83Eosinophilia (HP:0001880)1.99159668
84Peripheral hypomyelination (HP:0007182)1.98860759
85Reticulocytopenia (HP:0001896)1.97601872
86Flattened epiphyses (HP:0003071)1.97374409
87Hypertriglyceridemia (HP:0002155)1.97355615
88Chronic obstructive pulmonary disease (HP:0006510)1.97197647
89Obstructive lung disease (HP:0006536)1.97197647
90Supernumerary bones of the axial skeleton (HP:0009144)1.96682525
91Polycythemia (HP:0001901)1.96573019
92Abnormality of chromosome stability (HP:0003220)1.95847306
93Abnormality of skeletal muscle fiber size (HP:0012084)1.95396024
94Amaurosis fugax (HP:0100576)1.95111520
95Exercise-induced myalgia (HP:0003738)1.93917864
96Mediastinal lymphadenopathy (HP:0100721)1.93391299
97Fatigue (HP:0012378)1.93000255
98Nasal polyposis (HP:0100582)1.92511038
99Trismus (HP:0000211)1.91129451
100Long eyelashes (HP:0000527)1.90683624
101Gastrointestinal stroma tumor (HP:0100723)1.90463781
102Abnormality of the nasal mucosa (HP:0000433)1.89827692
103Abnormal large intestine physiology (HP:0012700)1.88474468
104Patellar dislocation (HP:0002999)1.88259203
105Patellar aplasia (HP:0006443)1.88106582
106Abnormality of the thoracic spine (HP:0100711)1.87526383
107Acute lymphatic leukemia (HP:0006721)1.87409683
108Birth length less than 3rd percentile (HP:0003561)1.87260432
109Increased variability in muscle fiber diameter (HP:0003557)1.87064415
110Difficulty climbing stairs (HP:0003551)1.86809828
111Recurrent bronchitis (HP:0002837)1.86368378
112Axonal loss (HP:0003447)1.85134726
113Stomatitis (HP:0010280)1.84134511
114Resting tremor (HP:0002322)1.84087535
115Leukocytosis (HP:0001974)1.83596689
116Short thumb (HP:0009778)1.83301505
117Thin ribs (HP:0000883)1.83058415
118Microtia (HP:0008551)1.82917548
119Bulbar palsy (HP:0001283)1.82273194
120Prominent nose (HP:0000448)1.81927782
121Deep philtrum (HP:0002002)1.81625608
122Rough bone trabeculation (HP:0100670)1.81153581
123IgG deficiency (HP:0004315)1.79940144
124Meningitis (HP:0001287)1.78981105
125Pustule (HP:0200039)1.78594995
126Meckel diverticulum (HP:0002245)1.78492382
127Nonimmune hydrops fetalis (HP:0001790)1.77432987
128Myositis (HP:0100614)1.76481843
129Colon cancer (HP:0003003)1.76459019
130Protrusio acetabuli (HP:0003179)1.76438321
131Truncus arteriosus (HP:0001660)1.76278401
132Vertebral compression fractures (HP:0002953)1.75926677
133Aplasia/Hypoplasia of the spleen (HP:0010451)1.75190568
134Impulsivity (HP:0100710)1.75111312
135Granulocytopenia (HP:0001913)1.74726540
136Recurrent abscess formation (HP:0002722)1.74491596
137Increased nuchal translucency (HP:0010880)1.74445333
138Gastrointestinal atresia (HP:0002589)1.73981619
139Malnutrition (HP:0004395)1.73928359
140Aplasia/Hypoplasia of the uvula (HP:0010293)1.73813072
141Upper motor neuron abnormality (HP:0002127)1.73110143
142Abnormality of the ileum (HP:0001549)1.72427586
143Shallow orbits (HP:0000586)1.72384880
144Onion bulb formation (HP:0003383)1.72253796
145Preauricular skin tag (HP:0000384)1.72218014
146Broad distal phalanx of finger (HP:0009836)1.72083162
147Ependymoma (HP:0002888)1.71796026
148Type 1 muscle fiber predominance (HP:0003803)1.71094591
149Stridor (HP:0010307)1.70654856
150IgA deficiency (HP:0002720)1.70645772
151Aplasia/Hypoplasia of the patella (HP:0006498)1.70613652
152Abnormality of the Achilles tendon (HP:0005109)1.70541119
153Overriding aorta (HP:0002623)1.69529216
154Cholecystitis (HP:0001082)1.69093534
155Abnormal gallbladder physiology (HP:0012438)1.69093534
156Absent radius (HP:0003974)1.68871831
157Optic neuritis (HP:0100653)1.68357078
158Retrobulbar optic neuritis (HP:0100654)1.68357078
159Supranuclear gaze palsy (HP:0000605)1.67220876
160Premature graying of hair (HP:0002216)1.66832108
161Pointed chin (HP:0000307)1.66781624
162Abnormality of the nasal septum (HP:0000419)1.66702413
163Fragile skin (HP:0001030)1.66448012
164Spontaneous hematomas (HP:0007420)1.66386673
165Dislocated radial head (HP:0003083)1.66298726
166Skin tags (HP:0010609)1.66093524
167Cellulitis (HP:0100658)1.65523388
168Aplasia/Hypoplasia of the thymus (HP:0010515)1.64562401
169Renovascular hypertension (HP:0100817)1.64345984
170Vertebral arch anomaly (HP:0008438)1.64203777
171Flared metaphyses (HP:0003015)1.63807472
172Decreased motor nerve conduction velocity (HP:0003431)1.62131742
173Distal lower limb muscle weakness (HP:0009053)1.61563515
174Thoracic kyphosis (HP:0002942)1.61311912
175Chronic mucocutaneous candidiasis (HP:0002728)1.61134553
176Recurrent cutaneous fungal infections (HP:0011370)1.61134553
177Cheilitis (HP:0100825)1.60668499
178Trigonocephaly (HP:0000243)1.58852680
179Panhypogammaglobulinemia (HP:0003139)1.58681264
180Inflammation of the large intestine (HP:0002037)1.55568965
181Selective tooth agenesis (HP:0001592)1.54987066
182Aplasia involving forearm bones (HP:0009822)1.54118077
183Absent forearm bone (HP:0003953)1.54118077
184Persistence of primary teeth (HP:0006335)1.53628445
185Abnormality of the columella (HP:0009929)1.53138378

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.21325761
2PRPF4B3.42909891
3CDK123.37335064
4ERN12.81379994
5MAP4K12.77266696
6SMG12.76833555
7STK102.47734280
8TXK2.40778309
9SIK12.35919348
10BRD42.27200003
11MAP3K142.24809824
12CDC72.13087942
13MAP3K101.98106638
14ICK1.97689869
15IRAK31.94210078
16MAP3K131.91441625
17TRPM71.88662459
18MKNK21.87082162
19ITK1.80546540
20TESK11.78128785
21TEC1.77868925
22CSK1.67728796
23SIK21.65600289
24PNCK1.61519710
25BTK1.59696542
26MAP3K111.53717484
27TGFBR21.51197194
28EEF2K1.50105033
29NEK21.48520740
30IRAK41.47836071
31MAPK151.46162806
32CHUK1.45193213
33DMPK1.43780577
34MST41.40037993
35BMX1.37727374
36MAP3K91.36489665
37NUAK11.33679507
38RPS6KB21.32418845
39ZAP701.31176205
40TTN1.30149413
41TAOK21.28467346
42IKBKB1.27223169
43KSR21.26439486
44MST1R1.26310546
45MKNK11.25000121
46FGFR41.23755790
47TSSK61.22905147
48DDR21.22736734
49CDK41.21146620
50CHEK11.20923161
51PTK61.20159366
52PLK41.19468516
53MARK21.17139772
54RPS6KA41.16815849
55JAK31.14336525
56MAP3K11.13264048
57BLK1.12239798
58NLK1.12053199
59LCK1.11535453
60PRKD21.10692549
61PIM11.10308455
62TAOK11.10214858
63ARAF1.10026864
64TTK1.07191293
65TYRO31.06564732
66* CDK71.06032505
67HCK1.05054321
68PDPK11.03388820
69CAMK1G1.02316181
70MARK31.01580229
71ATR1.01502353
72MAP2K31.00204000
73PRKD31.00089046
74TNK20.99955140
75AURKB0.99570959
76CDK60.99059920
77IKBKE0.98546997
78SRPK10.98497616
79CLK10.95773822
80WEE10.91437004
81MET0.89975677
82CDK90.88860471
83STK40.88751348
84CHEK20.86213861
85CDK30.86037380
86BRAF0.85418177
87EPHB10.84267683
88FGR0.84120530
89MTOR0.80821501
90MAPKAPK30.80644558
91GRK60.80317201
92KIT0.80064382
93PLK10.78776664
94CSF1R0.78674134
95ALK0.77815007
96RIPK10.77552471
97CDK20.76566124
98EPHA20.76531649
99TBK10.75346992
100JAK10.74366597
101ATM0.74207265
102PDK10.73744258
103PKN20.71619452
104PTK2B0.71512523
105RIPK40.70990864
106TGFBR10.70848580
107NME10.67119399
108MAP2K20.66711484
109TYK20.66092349
110RPS6KL10.65706089
111RPS6KC10.65706089
112MAPKAPK20.65250052
113LYN0.64718956
114CDC42BPA0.63595621
115MAP3K80.62153361
116TESK20.61390100
117PDGFRB0.60782965
118MAP3K30.60404168
119SYK0.59403384
120FES0.58151262
121PDGFRA0.57894296
122MAPK140.57606016
123MAPK110.57001546
124CSNK2A20.56680004
125NME20.54823076
126YES10.54619717
127CAMK1D0.54346221
128CSNK1E0.54264216
129MAPK70.54105304
130STK380.53807831
131MAP3K60.53769734
132MAP3K70.53313933
133RPS6KA20.53142456
134RPS6KA10.51954805
135LATS20.51722685
136MAPK10.51690099
137CDK10.51559338
138PLK30.51240746
139DYRK1B0.50757201
140LRRK20.50752236
141PTK20.50370563
142PIK3CG0.50320271
143MOS0.49393102
144SIK30.49052605
145CDK190.48908241
146WNK10.48394724
147PAK40.46637425
148RPS6KA60.46498951
149PIM20.46409305
150PRKG20.45970093
151CAMKK10.45235010
152MAPK120.44816623
153HIPK20.44646723
154RET0.43330191
155GSK3B0.43076432
156PASK0.42429640

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.60560138
2Spliceosome_Homo sapiens_hsa030402.52002277
3Mismatch repair_Homo sapiens_hsa034302.45160315
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10867192
5DNA replication_Homo sapiens_hsa030302.06595461
6Homologous recombination_Homo sapiens_hsa034401.91827337
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.91454882
8Fanconi anemia pathway_Homo sapiens_hsa034601.88121627
9RNA transport_Homo sapiens_hsa030131.86766108
10Base excision repair_Homo sapiens_hsa034101.86625359
11Other glycan degradation_Homo sapiens_hsa005111.84836918
12mRNA surveillance pathway_Homo sapiens_hsa030151.65448260
13T cell receptor signaling pathway_Homo sapiens_hsa046601.61397609
14Non-homologous end-joining_Homo sapiens_hsa034501.60991743
15RNA polymerase_Homo sapiens_hsa030201.58074935
16B cell receptor signaling pathway_Homo sapiens_hsa046621.55428482
17Hematopoietic cell lineage_Homo sapiens_hsa046401.53530826
18Antigen processing and presentation_Homo sapiens_hsa046121.53208167
19Graft-versus-host disease_Homo sapiens_hsa053321.48316847
20Measles_Homo sapiens_hsa051621.48061405
21Basal transcription factors_Homo sapiens_hsa030221.47933875
22Renal cell carcinoma_Homo sapiens_hsa052111.47103965
23RNA degradation_Homo sapiens_hsa030181.46801710
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45485159
25Prion diseases_Homo sapiens_hsa050201.43004666
26Cell cycle_Homo sapiens_hsa041101.42122707
27Osteoclast differentiation_Homo sapiens_hsa043801.40705335
28Herpes simplex infection_Homo sapiens_hsa051681.39471999
29Ribosome_Homo sapiens_hsa030101.39415412
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34976935
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34808779
32Nucleotide excision repair_Homo sapiens_hsa034201.29340355
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.29298965
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27880837
35p53 signaling pathway_Homo sapiens_hsa041151.27132529
36Notch signaling pathway_Homo sapiens_hsa043301.24031979
37Epstein-Barr virus infection_Homo sapiens_hsa051691.21446554
38Leishmaniasis_Homo sapiens_hsa051401.19901085
39Acute myeloid leukemia_Homo sapiens_hsa052211.17037703
40HTLV-I infection_Homo sapiens_hsa051661.16719995
41ErbB signaling pathway_Homo sapiens_hsa040121.16315010
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.13030922
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.10819858
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10811610
45Chronic myeloid leukemia_Homo sapiens_hsa052201.10568524
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.09424981
47Endometrial cancer_Homo sapiens_hsa052131.08754629
48Insulin signaling pathway_Homo sapiens_hsa049101.06499292
49Adherens junction_Homo sapiens_hsa045201.05682405
50mTOR signaling pathway_Homo sapiens_hsa041501.04872376
51MicroRNAs in cancer_Homo sapiens_hsa052061.03368719
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.01822767
53TNF signaling pathway_Homo sapiens_hsa046681.01066888
54Endocytosis_Homo sapiens_hsa041441.00480022
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00394836
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97950336
57Apoptosis_Homo sapiens_hsa042100.97946043
58Small cell lung cancer_Homo sapiens_hsa052220.96430542
59Hepatitis B_Homo sapiens_hsa051610.96410596
60Fructose and mannose metabolism_Homo sapiens_hsa000510.94653025
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.93045519
62Viral myocarditis_Homo sapiens_hsa054160.92388883
63GnRH signaling pathway_Homo sapiens_hsa049120.92219750
64Choline metabolism in cancer_Homo sapiens_hsa052310.91909281
65Lysine degradation_Homo sapiens_hsa003100.91455081
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91426714
67Shigellosis_Homo sapiens_hsa051310.89951925
68Glioma_Homo sapiens_hsa052140.89683574
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89431666
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88263315
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86805867
72Estrogen signaling pathway_Homo sapiens_hsa049150.86772378
73Influenza A_Homo sapiens_hsa051640.84806304
74Prostate cancer_Homo sapiens_hsa052150.81605040
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81533406
76Chemokine signaling pathway_Homo sapiens_hsa040620.79840247
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79537019
78Allograft rejection_Homo sapiens_hsa053300.78381389
79African trypanosomiasis_Homo sapiens_hsa051430.77972229
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77465893
81Pathways in cancer_Homo sapiens_hsa052000.77116039
82Long-term potentiation_Homo sapiens_hsa047200.76365415
83Insulin resistance_Homo sapiens_hsa049310.74752604
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74205119
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73627117
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73368346
87Pancreatic cancer_Homo sapiens_hsa052120.72991095
88Platelet activation_Homo sapiens_hsa046110.72615897
89Amoebiasis_Homo sapiens_hsa051460.72550663
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72298278
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.72156946
92TGF-beta signaling pathway_Homo sapiens_hsa043500.71600617
93Viral carcinogenesis_Homo sapiens_hsa052030.71517663
94Pyrimidine metabolism_Homo sapiens_hsa002400.70896664
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70882291
96Toxoplasmosis_Homo sapiens_hsa051450.69576457
97Autoimmune thyroid disease_Homo sapiens_hsa053200.69544657
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68646890
99Colorectal cancer_Homo sapiens_hsa052100.68171055
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67449923
101Malaria_Homo sapiens_hsa051440.66884465
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.66349472
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63862416
104Wnt signaling pathway_Homo sapiens_hsa043100.62349276
105Pentose phosphate pathway_Homo sapiens_hsa000300.61240864
106Sulfur relay system_Homo sapiens_hsa041220.60550052
107FoxO signaling pathway_Homo sapiens_hsa040680.59926141
108Thyroid cancer_Homo sapiens_hsa052160.59422658
109Legionellosis_Homo sapiens_hsa051340.58504549
110Prolactin signaling pathway_Homo sapiens_hsa049170.57334872
111Basal cell carcinoma_Homo sapiens_hsa052170.57079398
112Hippo signaling pathway_Homo sapiens_hsa043900.56250065
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55776341
114Type II diabetes mellitus_Homo sapiens_hsa049300.55747381
115MAPK signaling pathway_Homo sapiens_hsa040100.52866316
116Focal adhesion_Homo sapiens_hsa045100.52320936
117Non-small cell lung cancer_Homo sapiens_hsa052230.51818449
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51229469
119Proteoglycans in cancer_Homo sapiens_hsa052050.51084619
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50578961
121Hepatitis C_Homo sapiens_hsa051600.50119571
122Bladder cancer_Homo sapiens_hsa052190.49258500
123Salmonella infection_Homo sapiens_hsa051320.48542661
124HIF-1 signaling pathway_Homo sapiens_hsa040660.48222965
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45540739
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44812637
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43824249
128Melanoma_Homo sapiens_hsa052180.43168816
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.40929451
130Tuberculosis_Homo sapiens_hsa051520.40585418
131VEGF signaling pathway_Homo sapiens_hsa043700.40213266
132Rap1 signaling pathway_Homo sapiens_hsa040150.40126751
133Purine metabolism_Homo sapiens_hsa002300.38604536

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