CDK12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.56784761
2nuclear pore organization (GO:0006999)5.82994819
3positive regulation of transcription from RNA polymerase III promoter (GO:0045945)5.28203381
4protein localization to kinetochore (GO:0034501)4.97878855
5pore complex assembly (GO:0046931)4.97435485
6daunorubicin metabolic process (GO:0044597)4.80113138
7polyketide metabolic process (GO:0030638)4.80113138
8doxorubicin metabolic process (GO:0044598)4.80113138
9histone H4-K12 acetylation (GO:0043983)4.61436715
10pre-miRNA processing (GO:0031054)4.60673067
11regulation of nucleobase-containing compound transport (GO:0032239)4.52158469
12heterochromatin organization (GO:0070828)4.36510027
13regulation of nuclear cell cycle DNA replication (GO:0033262)4.35339415
14regulation of telomere maintenance via telomerase (GO:0032210)4.29622936
15mitotic sister chromatid segregation (GO:0000070)4.27722554
16negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.26687744
17chromatin assembly (GO:0031497)4.22684478
18protein localization to chromosome, centromeric region (GO:0071459)4.14836632
19sister chromatid segregation (GO:0000819)4.10393800
20histone H4-K5 acetylation (GO:0043981)4.08889886
21histone H4-K8 acetylation (GO:0043982)4.08889886
22DNA unwinding involved in DNA replication (GO:0006268)4.00600554
23regulation of histone H3-K27 methylation (GO:0061085)3.93392652
24histone H3-K4 methylation (GO:0051568)3.83719264
25maintenance of protein location in nucleus (GO:0051457)3.79818626
26negative regulation of cell cycle G2/M phase transition (GO:1902750)3.77499836
27mitotic chromosome condensation (GO:0007076)3.77108094
28mitotic sister chromatid cohesion (GO:0007064)3.75320287
29cytoplasmic mRNA processing body assembly (GO:0033962)3.66291138
30DNA replication-dependent nucleosome assembly (GO:0006335)3.64572058
31DNA replication-dependent nucleosome organization (GO:0034723)3.64572058
32positive regulation of protein import into nucleus, translocation (GO:0033160)3.61117896
33RNA stabilization (GO:0043489)3.59172729
34mRNA stabilization (GO:0048255)3.59172729
35histone H4-K16 acetylation (GO:0043984)3.58631919
36glucocorticoid receptor signaling pathway (GO:0042921)3.54185038
37positive regulation of DNA-dependent DNA replication (GO:2000105)3.50875679
38negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.50429303
39somite rostral/caudal axis specification (GO:0032525)3.49815435
40regulation of transcription from RNA polymerase I promoter (GO:0006356)3.48794023
41regulation of gene silencing by miRNA (GO:0060964)3.48491898
42regulation of gene silencing by RNA (GO:0060966)3.48491898
43regulation of posttranscriptional gene silencing (GO:0060147)3.48491898
44regulation of histone H3-K9 methylation (GO:0051570)3.41327079
45NLS-bearing protein import into nucleus (GO:0006607)3.40710444
46notochord development (GO:0030903)3.39055947
47regulation of MHC class I biosynthetic process (GO:0045343)3.37085200
48histone H3-K4 trimethylation (GO:0080182)3.35936939
49negative regulation of DNA repair (GO:0045738)3.35650789
50DNA duplex unwinding (GO:0032508)3.35208237
51DNA geometric change (GO:0032392)3.33997790
52negative regulation of histone methylation (GO:0031061)3.31834916
53positive regulation of chromosome segregation (GO:0051984)3.31829503
54DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.31394030
55negative regulation of epidermis development (GO:0045683)3.30643224
56monoubiquitinated protein deubiquitination (GO:0035520)3.30331899
57regulation of mammary gland epithelial cell proliferation (GO:0033599)3.26611971
58mitotic nuclear envelope disassembly (GO:0007077)3.24708414
59positive regulation of keratinocyte differentiation (GO:0045618)3.23961302
60RNA localization (GO:0006403)3.21191779
61histone lysine demethylation (GO:0070076)3.20689433
62regulation of histone methylation (GO:0031060)3.20436316
63DNA replication checkpoint (GO:0000076)3.16579137
64histone H3-K9 demethylation (GO:0033169)3.15020041
65spliceosomal tri-snRNP complex assembly (GO:0000244)3.14423594
66positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.12084714
67histone demethylation (GO:0016577)3.10483456
68regulation of NFAT protein import into nucleus (GO:0051532)3.09864423
69embryonic process involved in female pregnancy (GO:0060136)3.08882726
70regulation of telomere maintenance (GO:0032204)3.08852108
71muscle organ morphogenesis (GO:0048644)3.07269844
72corticosteroid receptor signaling pathway (GO:0031958)3.06953796
73regulation of RNA export from nucleus (GO:0046831)3.05686997
74DNA topological change (GO:0006265)3.04390581
75negative regulation of telomerase activity (GO:0051974)3.04109079
76interferon-gamma production (GO:0032609)3.03282757
77membrane disassembly (GO:0030397)3.03136519
78nuclear envelope disassembly (GO:0051081)3.03136519
79positive regulation by host of viral transcription (GO:0043923)2.97786258
80regulation of response to osmotic stress (GO:0047484)2.97606316
81regulation of double-strand break repair (GO:2000779)2.97578579
82intestinal epithelial cell development (GO:0060576)2.95825945
83negative regulation of keratinocyte proliferation (GO:0010839)2.95301339
84regulation of DNA-dependent DNA replication (GO:0090329)2.92536975
85regulation of gene silencing (GO:0060968)2.92453184
86regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.92275906
87negative regulation of translation, ncRNA-mediated (GO:0040033)2.88828533
88regulation of translation, ncRNA-mediated (GO:0045974)2.88828533
89negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.88828533
90response to epidermal growth factor (GO:0070849)2.88519405
91N-terminal protein amino acid acetylation (GO:0006474)2.88461111
92cellular response to epidermal growth factor stimulus (GO:0071364)2.87702618
93meiotic chromosome segregation (GO:0045132)2.87642003
94intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.87586117
95DNA damage response, signal transduction resulting in transcription (GO:0042772)2.86880048
96trophectodermal cell differentiation (GO:0001829)2.86571202
97positive regulation of DNA-templated transcription, initiation (GO:2000144)2.85612583
98rRNA transcription (GO:0009303)2.84477587
99spindle assembly (GO:0051225)2.83586621
100chromatin assembly or disassembly (GO:0006333)2.83491847
101negative regulation of histone modification (GO:0031057)2.83006461
102interkinetic nuclear migration (GO:0022027)2.80243980
103branching involved in mammary gland duct morphogenesis (GO:0060444)2.79923967
104definitive hemopoiesis (GO:0060216)2.78889437
105aminoglycoside antibiotic metabolic process (GO:0030647)2.77201951
106DNA conformation change (GO:0071103)2.76526024
107DNA packaging (GO:0006323)2.76422925
108positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76324975
109positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76324975
110positive regulation of mitotic sister chromatid separation (GO:1901970)2.76324975
111protein export from nucleus (GO:0006611)2.74086099
112peptidyl-lysine dimethylation (GO:0018027)2.73014018
113histone phosphorylation (GO:0016572)2.72030874
114paraxial mesoderm development (GO:0048339)2.71753074
115regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.71504223
116protein localization to chromosome (GO:0034502)2.67816745
117protein dealkylation (GO:0008214)2.67612207
118protein demethylation (GO:0006482)2.67612207
119sister chromatid cohesion (GO:0007062)2.67199347
120regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67175619
121regulation of chromatin silencing (GO:0031935)2.67169594
122response to UV-C (GO:0010225)2.66813257
123positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.66434538
124negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.65756327
125nuclear envelope organization (GO:0006998)2.64458073
126DNA replication initiation (GO:0006270)2.64327219
127mitotic metaphase plate congression (GO:0007080)2.64197428
128regulation of DNA damage checkpoint (GO:2000001)2.61804618
129histone H3 acetylation (GO:0043966)2.61793636
130DNA synthesis involved in DNA repair (GO:0000731)2.61391196
131mRNA transport (GO:0051028)2.61080392
132histone lysine methylation (GO:0034968)2.60875539
133peptidyl-lysine trimethylation (GO:0018023)2.60854476
134nucleus organization (GO:0006997)2.60344352
135positive regulation of gene expression, epigenetic (GO:0045815)2.59970025
136kinetochore organization (GO:0051383)2.59312296
137histone H3-K36 demethylation (GO:0070544)2.57445346
138intracellular estrogen receptor signaling pathway (GO:0030520)2.56773470
139positive regulation of cell cycle checkpoint (GO:1901978)2.56553613
140mammary gland epithelial cell proliferation (GO:0033598)2.55108202
141negative regulation of chromatin modification (GO:1903309)2.55103783
142megakaryocyte development (GO:0035855)2.54524853
143negative regulation of epidermal cell differentiation (GO:0045605)2.54360723
144nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.53792657
145regulation of translation in response to stress (GO:0043555)2.53695524
146regulation of histone H3-K4 methylation (GO:0051569)2.53592695
147primitive streak formation (GO:0090009)2.53513715
148regulation of protein polyubiquitination (GO:1902914)2.53039090
149chromosome condensation (GO:0030261)2.52517161
150positive regulation of histone deacetylation (GO:0031065)2.52184057
151histone methylation (GO:0016571)2.51534264
152regulation of sister chromatid cohesion (GO:0007063)2.51417147
153regulation of DNA endoreduplication (GO:0032875)2.51042517
154stress granule assembly (GO:0034063)2.51005161
155dosage compensation (GO:0007549)2.50935420
156protein K48-linked deubiquitination (GO:0071108)2.50730282
157peptidyl-lysine methylation (GO:0018022)2.49466748
158erythrocyte development (GO:0048821)2.48123183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.67236870
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.76727222
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.66196358
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.66196358
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.66196358
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95167578
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.94753013
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.60966999
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.15872609
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90821457
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.75780929
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.72778051
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.62773678
14TCF3_18692474_ChIP-Seq_MESCs_Mouse2.25814130
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.25451781
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.12439659
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.00497538
18MYC_22102868_ChIP-Seq_BL_Human1.94187800
19VDR_21846776_ChIP-Seq_THP-1_Human1.93050468
20GATA1_22025678_ChIP-Seq_K562_Human1.85422441
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80244907
22TCF3_18692474_ChIP-Seq_MEFs_Mouse1.79150467
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.78556328
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.74773790
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73342733
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.70400381
27NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.70324454
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.68373079
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.67469035
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66538279
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64187956
32ZNF263_19887448_ChIP-Seq_K562_Human1.63770872
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55481818
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54428240
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54056454
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52259664
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51655329
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49137505
39NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.48615310
40CHD1_26751641_Chip-Seq_LNCaP_Human1.45040506
41SCL_19346495_ChIP-Seq_HPC-7_Human1.44908871
42CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.44407324
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.44134763
44TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.42898777
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.42218188
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39949677
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39941870
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37320516
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37298512
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36769821
51TCF7_22412390_ChIP-Seq_EML_Mouse1.36725092
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36181997
53* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31659293
54POU5F1_16518401_ChIP-PET_MESCs_Mouse1.31658093
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31381857
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30053983
57AR_21909140_ChIP-Seq_LNCAP_Human1.29432137
58FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.29220510
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29079967
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.28545144
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27923297
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24966061
63* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24636131
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23746528
65VDR_24763502_ChIP-Seq_THP-1_Human1.21647688
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21354955
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21041452
68* MAF_26560356_Chip-Seq_TH1_Human1.20929177
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20878611
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19569772
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18698492
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18683566
73NANOG_18692474_ChIP-Seq_MESCs_Mouse1.17878444
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16520154
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16321103
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.15097442
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14118126
78MYB_26560356_Chip-Seq_TH1_Human1.12161563
79CIITA_25753668_ChIP-Seq_RAJI_Human1.11711501
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11202784
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11202784
82PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09863589
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.09674839
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09593035
85KDM2B_26808549_Chip-Seq_DND41_Human1.08449228
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08302465
87SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08205002
88FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07362457
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06318972
90STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06052265
91NANOG_21062744_ChIP-ChIP_HESCs_Human1.05946700
92* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05180862
93MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05136358
94POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05114425
95NCOR1_26117541_ChIP-Seq_K562_Human1.04889070
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04760666
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03696924
98SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02294168
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01734962
100ATF3_27146783_Chip-Seq_COLON_Human1.00344843
101FOXO3_23340844_ChIP-Seq_DLD1_Human1.00313121
102NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00264318
103ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99089208
104UTX_26944678_Chip-Seq_JUKART_Human0.98723376
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98534665
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97815434
107TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97584337
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97438207
109POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96057554
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96015054
111TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95282996
112STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94948278
113KDM5A_27292631_Chip-Seq_BREAST_Human0.94208864
114NANOG_16518401_ChIP-PET_MESCs_Mouse0.94099256
115KDM2B_26808549_Chip-Seq_JURKAT_Human0.93854793
116* RUNX1_22412390_ChIP-Seq_EML_Mouse0.93835872
117FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93810205
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93148234
119IRF1_19129219_ChIP-ChIP_H3396_Human0.92545071
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91882769
121ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91600978
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91596207
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91008813
124EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90630013
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90494956
126CLOCK_20551151_ChIP-Seq_293T_Human0.90178728
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90003974
128IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89942119
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89589764
130SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88174903
131POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.87726660
132KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87176411
133* UBF1/2_26484160_Chip-Seq_HMECs_Human0.86978607
134RACK7_27058665_Chip-Seq_MCF-7_Human0.86976114
135GATA6_25053715_ChIP-Seq_YYC3_Human0.86279899
136CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.86178438
137ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84920254
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82679622
139IRF8_22096565_ChIP-ChIP_GC-B_Human0.82526321
140CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82392881
141STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81530708
142NANOG_18692474_ChIP-Seq_MEFs_Mouse0.79638004
143NANOG_16153702_ChIP-ChIP_HESCs_Human0.78633930
144* MYB_26560356_Chip-Seq_TH2_Human0.77576706
145PADI4_21655091_ChIP-ChIP_MCF-7_Human0.77175174
146KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76885269
147BRD4_25478319_ChIP-Seq_HGPS_Human0.75850305
148TFEB_21752829_ChIP-Seq_HELA_Human0.73974066
149NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.72256180
150PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71516452
151BRD4_27068464_Chip-Seq_AML-cells_Mouse0.71333380

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.51156806
2MP0004264_abnormal_extraembryonic_tissu3.14389291
3MP0003890_abnormal_embryonic-extraembry2.86920954
4MP0002009_preneoplasia2.81618101
5MP0010352_gastrointestinal_tract_polyps2.71005036
6MP0002254_reproductive_system_inflammat2.56600314
7MP0010094_abnormal_chromosome_stability2.53470588
8MP0004957_abnormal_blastocyst_morpholog2.48012456
9MP0003111_abnormal_nucleus_morphology2.46615417
10MP0003077_abnormal_cell_cycle2.46381039
11MP0006292_abnormal_olfactory_placode2.31663367
12MP0003121_genomic_imprinting2.31316254
13MP0003705_abnormal_hypodermis_morpholog2.28533443
14MP0005451_abnormal_body_composition2.19826210
15MP0002396_abnormal_hematopoietic_system1.99547654
16MP0001672_abnormal_embryogenesis/_devel1.97472927
17MP0005380_embryogenesis_phenotype1.97472927
18MP0003787_abnormal_imprinting1.97466279
19MP0000569_abnormal_digit_pigmentation1.92087512
20MP0000350_abnormal_cell_proliferation1.90148851
21MP0004233_abnormal_muscle_weight1.87088495
22MP0003693_abnormal_embryo_hatching1.85700108
23MP0003984_embryonic_growth_retardation1.85364195
24MP0002088_abnormal_embryonic_growth/wei1.84498332
25MP0001293_anophthalmia1.79740478
26MP0002166_altered_tumor_susceptibility1.78214893
27MP0005409_darkened_coat_color1.76781200
28MP0005076_abnormal_cell_differentiation1.72805763
29MP0005257_abnormal_intraocular_pressure1.72130725
30MP0002086_abnormal_extraembryonic_tissu1.69077275
31MP0008007_abnormal_cellular_replicative1.66613838
32MP0010307_abnormal_tumor_latency1.66054549
33MP0008058_abnormal_DNA_repair1.63617638
34MP0003943_abnormal_hepatobiliary_system1.59388032
35MP0005075_abnormal_melanosome_morpholog1.57165076
36MP0002084_abnormal_developmental_patter1.56156721
37MP0003011_delayed_dark_adaptation1.55409301
38MP0002085_abnormal_embryonic_tissue1.50146694
39MP0004197_abnormal_fetal_growth/weight/1.49283716
40MP0003123_paternal_imprinting1.46425775
41MP0001849_ear_inflammation1.46072521
42MP0005394_taste/olfaction_phenotype1.44309838
43MP0005499_abnormal_olfactory_system1.44309838
44MP0001730_embryonic_growth_arrest1.44116932
45MP0003300_gastrointestinal_ulcer1.41359488
46MP0010234_abnormal_vibrissa_follicle1.39739851
47MP0002277_abnormal_respiratory_mucosa1.38111784
48MP0000490_abnormal_crypts_of1.37568707
49MP0003091_abnormal_cell_migration1.35553581
50MP0002092_abnormal_eye_morphology1.34506412
51MP0002006_tumorigenesis1.33398253
52MP0000432_abnormal_head_morphology1.32121496
53MP0001697_abnormal_embryo_size1.25345872
54MP0008877_abnormal_DNA_methylation1.22066612
55MP0004808_abnormal_hematopoietic_stem1.20626407
56MP0003937_abnormal_limbs/digits/tail_de1.20270126
57MP0002796_impaired_skin_barrier1.19320190
58MP0003935_abnormal_craniofacial_develop1.18422849
59MP0009697_abnormal_copulation1.17581770
60MP0009672_abnormal_birth_weight1.17120498
61MP0003656_abnormal_erythrocyte_physiolo1.15240556
62MP0009703_decreased_birth_body1.12279144
63MP0002925_abnormal_cardiovascular_devel1.09073443
64MP0002332_abnormal_exercise_endurance1.07995198
65MP0008932_abnormal_embryonic_tissue1.07645223
66MP0000313_abnormal_cell_death1.07278847
67MP0003122_maternal_imprinting1.06890093
68MP0002653_abnormal_ependyma_morphology1.05219129
69MP0000428_abnormal_craniofacial_morphol1.04687198
70MP0005248_abnormal_Harderian_gland1.03606379
71MP0010030_abnormal_orbit_morphology1.02711833
72MP0003718_maternal_effect1.02109040
73MP0002080_prenatal_lethality1.01423217
74MP0003566_abnormal_cell_adhesion1.00997578
75MP0008961_abnormal_basal_metabolism1.00726696
76MP0002098_abnormal_vibrissa_morphology0.99191704
77MP0002877_abnormal_melanocyte_morpholog0.98014971
78MP0003755_abnormal_palate_morphology0.97550704
79MP0000383_abnormal_hair_follicle0.95112140
80MP0010630_abnormal_cardiac_muscle0.94520682
81MP0001661_extended_life_span0.94269620
82MP0003786_premature_aging0.93775330
83MP0002233_abnormal_nose_morphology0.93527487
84MP0003115_abnormal_respiratory_system0.93256194
85MP0001216_abnormal_epidermal_layer0.92366794
86MP0003119_abnormal_digestive_system0.92158564
87MP0000703_abnormal_thymus_morphology0.91956058
88MP0009278_abnormal_bone_marrow0.91847344
89MP0004947_skin_inflammation0.91642087
90MP0003448_altered_tumor_morphology0.90561803
91MP0005023_abnormal_wound_healing0.90478346
92MP0002697_abnormal_eye_size0.90105799
93MP0000733_abnormal_muscle_development0.89534466
94MP0010678_abnormal_skin_adnexa0.88811581
95MP0003938_abnormal_ear_development0.88007220
96MP0009115_abnormal_fat_cell0.87899512
97MP0002932_abnormal_joint_morphology0.87684033
98MP0005384_cellular_phenotype0.87033728
99MP0002398_abnormal_bone_marrow0.87021237
100MP0002019_abnormal_tumor_incidence0.86642109
101MP0001286_abnormal_eye_development0.86537391
102MP0002132_abnormal_respiratory_system0.86405471
103MP0005501_abnormal_skin_physiology0.86069060
104MP0001873_stomach_inflammation0.84027108
105MP0003828_pulmonary_edema0.83092842
106MP0004185_abnormal_adipocyte_glucose0.82710902
107MP0001915_intracranial_hemorrhage0.82665686
108MP0002089_abnormal_postnatal_growth/wei0.82418838
109MP0003183_abnormal_peptide_metabolism0.81843484
110MP0001800_abnormal_humoral_immune0.80799896
111MP0000003_abnormal_adipose_tissue0.80361527
112MP0005310_abnormal_salivary_gland0.80230738
113MP0002127_abnormal_cardiovascular_syste0.79714303
114MP0002114_abnormal_axial_skeleton0.79342366
115MP0004381_abnormal_hair_follicle0.79281348
116MP0003453_abnormal_keratinocyte_physiol0.77533453
117MP0002722_abnormal_immune_system0.77264077
118MP0005367_renal/urinary_system_phenotyp0.77005414
119MP0000516_abnormal_urinary_system0.77005414
120MP0003699_abnormal_female_reproductive0.76715654
121MP0008770_decreased_survivor_rate0.75438658
122MP0001835_abnormal_antigen_presentation0.74256084
123MP0004858_abnormal_nervous_system0.73967079
124MP0003763_abnormal_thymus_physiology0.73857217
125MP0000627_abnormal_mammary_gland0.73809169
126MP0000377_abnormal_hair_follicle0.73404167
127MP0000689_abnormal_spleen_morphology0.72954460
128MP0003315_abnormal_perineum_morphology0.72464929
129MP0009333_abnormal_splenocyte_physiolog0.72442061
130MP0000049_abnormal_middle_ear0.72358051
131MP0003941_abnormal_skin_development0.72093343
132MP0005621_abnormal_cell_physiology0.72016110
133MP0001881_abnormal_mammary_gland0.71875384
134MP0000858_altered_metastatic_potential0.71583662
135MP0005397_hematopoietic_system_phenotyp0.71493200
136MP0001545_abnormal_hematopoietic_system0.71493200
137MP0005666_abnormal_adipose_tissue0.71362158
138MP0002116_abnormal_craniofacial_bone0.70648273
139MP0002429_abnormal_blood_cell0.69276877
140MP0005375_adipose_tissue_phenotype0.68518412
141MP0001270_distended_abdomen0.68464190
142MP0009931_abnormal_skin_appearance0.68257636
143MP0001851_eye_inflammation0.67910850
144MP0003868_abnormal_feces_composition0.65446343

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)4.67377060
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.56057627
3Chromsome breakage (HP:0040012)4.46541976
4Bilateral microphthalmos (HP:0007633)3.99581135
5Ependymoma (HP:0002888)3.67522122
6Rib fusion (HP:0000902)3.65686857
7Rhabdomyosarcoma (HP:0002859)3.25561495
8Volvulus (HP:0002580)3.18365796
9Flat acetabular roof (HP:0003180)3.16567007
10Acute myeloid leukemia (HP:0004808)3.15405080
11Deep philtrum (HP:0002002)3.12412157
12Sparse lateral eyebrow (HP:0005338)3.12084654
13Neoplasm of striated muscle (HP:0009728)3.10359971
14Hepatoblastoma (HP:0002884)3.04646296
15Birth length less than 3rd percentile (HP:0003561)3.00169284
16Dysmetric saccades (HP:0000641)2.98047699
17Astrocytoma (HP:0009592)2.97984013
18Abnormality of the astrocytes (HP:0100707)2.97984013
19Intestinal fistula (HP:0100819)2.95473013
20Abnormality of the fingertips (HP:0001211)2.86779140
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.86195037
22Impulsivity (HP:0100710)2.81101118
23Nephroblastoma (Wilms tumor) (HP:0002667)2.78489477
24Acute lymphatic leukemia (HP:0006721)2.77777544
25Meckel diverticulum (HP:0002245)2.72483756
26Ectopic kidney (HP:0000086)2.58833672
27Narrow palate (HP:0000189)2.56679263
28Embryonal renal neoplasm (HP:0011794)2.56035984
29Abnormality of the ileum (HP:0001549)2.55662968
30Medulloblastoma (HP:0002885)2.55219876
31Rectal fistula (HP:0100590)2.52309719
32Rectovaginal fistula (HP:0000143)2.52309719
33Hyperacusis (HP:0010780)2.47749711
34Short humerus (HP:0005792)2.46530186
35Abnormality of chromosome stability (HP:0003220)2.46437089
36Glioma (HP:0009733)2.45586956
37Abnormality of the lower motor neuron (HP:0002366)2.44258831
38Prominent nose (HP:0000448)2.41686642
39Absent frontal sinuses (HP:0002688)2.41252084
40Low anterior hairline (HP:0000294)2.38824649
41Aplasia/hypoplasia of the humerus (HP:0006507)2.38549579
42Supernumerary ribs (HP:0005815)2.37287843
43Broad face (HP:0000283)2.37051447
44Sandal gap (HP:0001852)2.33696304
45Lip pit (HP:0100267)2.32238320
46Neonatal hypoglycemia (HP:0001998)2.31636401
47Large earlobe (HP:0009748)2.30198915
48Long eyelashes (HP:0000527)2.28314942
49Shawl scrotum (HP:0000049)2.27489860
50Neoplasm of the oral cavity (HP:0100649)2.27208439
51Overlapping toe (HP:0001845)2.26805744
52Abnormality of the distal phalanx of the thumb (HP:0009617)2.25972500
53Fused cervical vertebrae (HP:0002949)2.24857897
54Abnormality of the phalanges of the hallux (HP:0010057)2.19599726
55Asymmetry of the thorax (HP:0001555)2.18907946
56Heterotopia (HP:0002282)2.18055344
57Skin tags (HP:0010609)2.17904904
58Preauricular skin tag (HP:0000384)2.17824443
59Ankyloglossia (HP:0010296)2.17529099
60Abnormality of the columella (HP:0009929)2.16798617
61Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.16096240
62Hypochromic anemia (HP:0001931)2.15531354
63Supernumerary spleens (HP:0009799)2.13887005
64Abnormal lung lobation (HP:0002101)2.13735212
65Abnormal foot bone ossification (HP:0010675)2.12617991
66Relative macrocephaly (HP:0004482)2.11650273
67Abnormality of the preputium (HP:0100587)2.10835995
68Small intestinal stenosis (HP:0012848)2.10540916
69Duodenal stenosis (HP:0100867)2.10540916
70Obsessive-compulsive behavior (HP:0000722)2.09994517
71Supernumerary bones of the axial skeleton (HP:0009144)2.09522775
72Subacute progressive viral hepatitis (HP:0006572)2.08888915
73Myelodysplasia (HP:0002863)2.08839944
74Septate vagina (HP:0001153)2.07584755
75Abnormality of chromosome segregation (HP:0002916)2.05762454
76Vaginal fistula (HP:0004320)2.04799221
77Capillary hemangiomas (HP:0005306)2.04228417
78Papillary thyroid carcinoma (HP:0002895)2.01937146
79Diastasis recti (HP:0001540)1.97341770
80Persistence of primary teeth (HP:0006335)1.97302074
81Broad thumb (HP:0011304)1.96913913
8211 pairs of ribs (HP:0000878)1.95818474
83Abnormality of the labia minora (HP:0012880)1.94861836
84Preauricular pit (HP:0004467)1.93933506
85Periauricular skin pits (HP:0100277)1.93933506
86Aplasia/Hypoplasia of the sternum (HP:0006714)1.92549332
87Abnormality of the salivary glands (HP:0010286)1.91935165
88Advanced eruption of teeth (HP:0006288)1.91666579
89Smooth philtrum (HP:0000319)1.90955238
90Short 5th finger (HP:0009237)1.89858800
91Increased nuchal translucency (HP:0010880)1.89824513
92Anal stenosis (HP:0002025)1.89745838
93Abnormality of the thoracic spine (HP:0100711)1.87634477
94Acanthocytosis (HP:0001927)1.86890822
95Deep palmar crease (HP:0006191)1.86358253
96Right ventricular cardiomyopathy (HP:0011663)1.86247219
97Dislocated radial head (HP:0003083)1.86193228
98Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.85506314
99Sloping forehead (HP:0000340)1.83934129
100Uterine leiomyosarcoma (HP:0002891)1.83800758
101Leiomyosarcoma (HP:0100243)1.83800758
102Malignant gastrointestinal tract tumors (HP:0006749)1.83693754
103Gastrointestinal carcinoma (HP:0002672)1.83693754
104Underdeveloped nasal alae (HP:0000430)1.82644788
105Abnormal tarsal ossification (HP:0008369)1.82625055
106Renovascular hypertension (HP:0100817)1.81579882
107Hypopigmentation of the fundus (HP:0007894)1.79503820
108Skin pits (HP:0100276)1.79241689
109Vertebral fusion (HP:0002948)1.79065207
110Macroorchidism (HP:0000053)1.78466589
111Self-mutilation (HP:0000742)1.76860556
112Bifid tongue (HP:0010297)1.75625450
113Clubbing of toes (HP:0100760)1.75388385
114Cutis marmorata (HP:0000965)1.75007477
115Abnormality of the duodenum (HP:0002246)1.74492925
116Multiple enchondromatosis (HP:0005701)1.74285058
117Somatic mutation (HP:0001428)1.74278150
118Thick eyebrow (HP:0000574)1.74267148
119Deviation of the thumb (HP:0009603)1.73723925
120Missing ribs (HP:0000921)1.73539277
121Pseudobulbar signs (HP:0002200)1.72635145
122Abnormality of the radial head (HP:0003995)1.72282913
123Urethral obstruction (HP:0000796)1.72175424
124Wide nose (HP:0000445)1.72119359
125Combined immunodeficiency (HP:0005387)1.71494818
126Deep venous thrombosis (HP:0002625)1.71126869
127Abnormality of oral frenula (HP:0000190)1.70959718
128Premature skin wrinkling (HP:0100678)1.69321717
129Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69156516
130Abnormality of the pubic bones (HP:0003172)1.68895220
131Transitional cell carcinoma of the bladder (HP:0006740)1.68866994
132Proximal placement of thumb (HP:0009623)1.68619690
133Spinal cord lesions (HP:0100561)1.68567307
134Syringomyelia (HP:0003396)1.68567307
135Broad palm (HP:0001169)1.68331057
136Ulnar bowing (HP:0003031)1.68186511
137Poikiloderma (HP:0001029)1.67677430
138Abnormality of the carotid arteries (HP:0005344)1.67507881
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66981145
140Limited elbow extension (HP:0001377)1.66636526
141Vertebral arch anomaly (HP:0008438)1.66549860
142Selective tooth agenesis (HP:0001592)1.66278643
143Hypoplastic scapulae (HP:0000882)1.65928720
144Aplasia/Hypoplasia of the scapulae (HP:0006713)1.65928720
145Abnormality of the nasal septum (HP:0000419)1.65828606
146Anomalous pulmonary venous return (HP:0010772)1.65772485
147Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.65566621
148Renal duplication (HP:0000075)1.65275090
149Cafe-au-lait spot (HP:0000957)1.64860382
150Truncal obesity (HP:0001956)1.64205006
151Short chin (HP:0000331)1.63755206
152Viral hepatitis (HP:0006562)1.62361068
153Facial hemangioma (HP:0000329)1.60295078
154Intestinal malrotation (HP:0002566)1.58976656
155Abnormality of homocysteine metabolism (HP:0010919)1.58935708
156Homocystinuria (HP:0002156)1.58935708
157Nasolacrimal duct obstruction (HP:0000579)1.58914926
158Thoracic kyphosis (HP:0002942)1.57194974
159Colitis (HP:0002583)1.55302051
160Abnormality of the lacrimal duct (HP:0011481)1.54319984
161Cubitus valgus (HP:0002967)1.53405293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* CDK124.81505416
2TRIB32.91420282
3CDC72.87919255
4TTK2.83821870
5LATS12.76400961
6STK102.75209950
7GRK62.64369292
8ERN12.61052648
9BRD42.58261704
10GRK52.32354948
11SMG12.20945310
12CSF1R2.09201129
13FGFR42.06705335
14CHEK22.02646163
15TGFBR21.94601442
16NEK21.92884898
17EPHA21.79331664
18GRK11.71519182
19MAP3K101.69307284
20CAMK1D1.65555040
21FGFR31.64081713
22MAPK71.63849662
23STK31.60890723
24TYRO31.58565124
25WNK11.57636859
26ADRBK21.55349380
27CHEK11.54345430
28PLK11.46040289
29MTOR1.35488899
30SRPK11.33624147
31CHUK1.30562984
32CDK41.29318759
33STK41.27808476
34ATM1.26801871
35ATR1.24790713
36* CDK71.21828676
37MATK1.17600038
38ZAK1.13516006
39GRK71.13218391
40MST1R1.13084860
41PNCK1.09859945
42MELK1.09792771
43CAMK41.08132095
44AKT31.07931556
45MAPK111.05839848
46PIM11.05790390
47AURKB1.04572952
48MKNK21.04275964
49NLK0.98709631
50CDK20.98213537
51IRAK30.98080386
52BRSK20.97501497
53MARK20.95653714
54CDK60.94558881
55EIF2AK20.93154540
56CSK0.92285601
57CAMK1G0.92247812
58ALK0.91121816
59IKBKB0.88773467
60CDK90.88684689
61TSSK60.87461822
62HIPK20.85171806
63JAK30.84820184
64MAP2K30.83972764
65KSR20.83340358
66RIPK40.83301472
67TRPM70.83240400
68MAP3K140.83084984
69MAP3K20.82769001
70CDC42BPA0.82418004
71NUAK10.80867593
72SGK30.79513948
73RPS6KB20.78859626
74PKN20.77501120
75PLK40.76282135
76STK38L0.75422153
77MAP3K130.74417082
78MOS0.72306167
79IRAK10.71957015
80CDK10.70161278
81AKT20.69103250
82NEK90.67794606
83MAPK140.67305680
84MARK30.67118321
85RPS6KA40.66353207
86BMX0.65595061
87RET0.64921901
88SGK20.64877163
89PAK40.64566940
90EEF2K0.61448126
91MAP3K80.60624788
92MET0.60561897
93LATS20.59443832
94MKNK10.58767140
95RAF10.58682603
96TLK10.57956733
97STK240.57667179
98CDK30.57293558
99ITK0.56675370
100MAPK100.55989799
101PDGFRB0.55762616
102MAPK10.55011325
103MAP4K10.53112411
104YES10.52130184
105IRAK40.51926130
106AKT10.51754032
107GSK3B0.51567871
108ICK0.50742828
109TYK20.49932995
110MAP3K70.48127027
111CSNK1D0.47962729
112HCK0.47586045
113PRKG20.47427679
114DMPK0.47243180
115SCYL20.47091952
116SIK20.46039367
117MAP3K10.45010560
118PDGFRA0.44667159
119TAF10.43079954
120DYRK30.42208788
121EIF2AK10.42078621
122CSNK1E0.41669819
123NEK60.41242711
124RIPK10.41187247
125WEE10.41064129
126PRKAA20.40940173
127JAK10.40298863
128CLK10.37976916
129PAK20.37937246
130SIK10.37885934
131PASK0.37879075
132PRKDC0.37855777
133IGF1R0.36820658
134RPS6KA50.36476311
135PRKAA10.36167506
136PRPF4B0.35312464
137CDK80.35021777

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.11611391
2Fanconi anemia pathway_Homo sapiens_hsa034602.38104783
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.16599993
4Cell cycle_Homo sapiens_hsa041102.12804818
5RNA transport_Homo sapiens_hsa030132.05455130
6mRNA surveillance pathway_Homo sapiens_hsa030152.02631686
7Non-homologous end-joining_Homo sapiens_hsa034501.80700340
8MicroRNAs in cancer_Homo sapiens_hsa052061.74497724
9Transcriptional misregulation in cancer_Homo sapiens_hsa052021.74019068
10Vitamin B6 metabolism_Homo sapiens_hsa007501.73791469
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.72795745
12Mismatch repair_Homo sapiens_hsa034301.72150034
13One carbon pool by folate_Homo sapiens_hsa006701.70432253
14Homologous recombination_Homo sapiens_hsa034401.62975711
15Herpes simplex infection_Homo sapiens_hsa051681.61599412
16p53 signaling pathway_Homo sapiens_hsa041151.55361170
17Systemic lupus erythematosus_Homo sapiens_hsa053221.50293892
18Renal cell carcinoma_Homo sapiens_hsa052111.48954354
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.47579710
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46414837
21Lysine degradation_Homo sapiens_hsa003101.45788539
22mTOR signaling pathway_Homo sapiens_hsa041501.42911550
23ErbB signaling pathway_Homo sapiens_hsa040121.39091315
24Basal transcription factors_Homo sapiens_hsa030221.38664960
25RNA degradation_Homo sapiens_hsa030181.37769649
26Adherens junction_Homo sapiens_hsa045201.36812038
27DNA replication_Homo sapiens_hsa030301.36097383
28Spliceosome_Homo sapiens_hsa030401.32694127
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.31920355
30Notch signaling pathway_Homo sapiens_hsa043301.27762016
31Viral carcinogenesis_Homo sapiens_hsa052031.27638008
32Small cell lung cancer_Homo sapiens_hsa052221.25210429
33Base excision repair_Homo sapiens_hsa034101.20765865
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19284785
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15238199
36HTLV-I infection_Homo sapiens_hsa051661.13766646
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13370939
38Basal cell carcinoma_Homo sapiens_hsa052171.11494710
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07093158
40Influenza A_Homo sapiens_hsa051641.06667679
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05950943
42Thyroid cancer_Homo sapiens_hsa052161.05922671
43Fatty acid biosynthesis_Homo sapiens_hsa000611.05498886
44Primary immunodeficiency_Homo sapiens_hsa053401.04908579
45Acute myeloid leukemia_Homo sapiens_hsa052211.04511871
46Measles_Homo sapiens_hsa051621.04225392
47Glioma_Homo sapiens_hsa052141.02705177
48Pancreatic cancer_Homo sapiens_hsa052120.99702352
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.97826036
50B cell receptor signaling pathway_Homo sapiens_hsa046620.97016455
51Insulin resistance_Homo sapiens_hsa049310.95771555
52Chronic myeloid leukemia_Homo sapiens_hsa052200.95555258
53Apoptosis_Homo sapiens_hsa042100.95458779
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.93387005
55Hematopoietic cell lineage_Homo sapiens_hsa046400.92328862
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92150543
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91310516
58Pathways in cancer_Homo sapiens_hsa052000.91160384
59Leishmaniasis_Homo sapiens_hsa051400.90315376
60TGF-beta signaling pathway_Homo sapiens_hsa043500.90083681
61T cell receptor signaling pathway_Homo sapiens_hsa046600.89519454
62VEGF signaling pathway_Homo sapiens_hsa043700.89459730
63HIF-1 signaling pathway_Homo sapiens_hsa040660.88822872
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86955191
65Prostate cancer_Homo sapiens_hsa052150.86180392
66Inositol phosphate metabolism_Homo sapiens_hsa005620.84904560
67Hippo signaling pathway_Homo sapiens_hsa043900.84442186
68Dorso-ventral axis formation_Homo sapiens_hsa043200.83899160
69Insulin signaling pathway_Homo sapiens_hsa049100.83869819
70Proteoglycans in cancer_Homo sapiens_hsa052050.83246487
71Colorectal cancer_Homo sapiens_hsa052100.82791663
72Toxoplasmosis_Homo sapiens_hsa051450.81740940
73Antigen processing and presentation_Homo sapiens_hsa046120.81473443
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81448914
75Non-small cell lung cancer_Homo sapiens_hsa052230.80005529
76Hepatitis B_Homo sapiens_hsa051610.79468516
77Fructose and mannose metabolism_Homo sapiens_hsa000510.79112579
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78473281
79TNF signaling pathway_Homo sapiens_hsa046680.77854541
80Nucleotide excision repair_Homo sapiens_hsa034200.76151084
81Type II diabetes mellitus_Homo sapiens_hsa049300.75385266
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74231625
83Viral myocarditis_Homo sapiens_hsa054160.73729409
84Selenocompound metabolism_Homo sapiens_hsa004500.72140963
85Wnt signaling pathway_Homo sapiens_hsa043100.71744881
86Epstein-Barr virus infection_Homo sapiens_hsa051690.68122795
87Osteoclast differentiation_Homo sapiens_hsa043800.68086205
88Estrogen signaling pathway_Homo sapiens_hsa049150.67953726
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.66558621
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65853098
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.65771644
92Circadian rhythm_Homo sapiens_hsa047100.65278283
93Arachidonic acid metabolism_Homo sapiens_hsa005900.64844772
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64135625
95Choline metabolism in cancer_Homo sapiens_hsa052310.63056021
96AMPK signaling pathway_Homo sapiens_hsa041520.61912917
97Endometrial cancer_Homo sapiens_hsa052130.61911597
98FoxO signaling pathway_Homo sapiens_hsa040680.60708746
99Platelet activation_Homo sapiens_hsa046110.60451808
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58130348
101Hedgehog signaling pathway_Homo sapiens_hsa043400.57473825
102Prolactin signaling pathway_Homo sapiens_hsa049170.53914068
103Melanoma_Homo sapiens_hsa052180.53654367
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53124732
105Graft-versus-host disease_Homo sapiens_hsa053320.52464705
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51542316
107Allograft rejection_Homo sapiens_hsa053300.50298815
108Rap1 signaling pathway_Homo sapiens_hsa040150.50126208
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49657428
110Focal adhesion_Homo sapiens_hsa045100.48774567
111Hepatitis C_Homo sapiens_hsa051600.48714630
112Legionellosis_Homo sapiens_hsa051340.48096555
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.47913027
114Bladder cancer_Homo sapiens_hsa052190.47911138
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.47468414
116Linoleic acid metabolism_Homo sapiens_hsa005910.47143987
117GnRH signaling pathway_Homo sapiens_hsa049120.47060781
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46260613
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.46076207
120Malaria_Homo sapiens_hsa051440.45418616
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45320044
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45065476
123Other glycan degradation_Homo sapiens_hsa005110.44931137
124Glucagon signaling pathway_Homo sapiens_hsa049220.43862819

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