CDK13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of memory T cell differentiation (GO:0043380)8.21109694
2regulation of establishment of cell polarity (GO:2000114)7.98327283
3negative regulation of type 2 immune response (GO:0002829)7.68450221
4regulation of MHC class I biosynthetic process (GO:0045343)7.63927286
5negative regulation of multicellular organism growth (GO:0040015)6.82374201
6regulation of establishment or maintenance of cell polarity (GO:0032878)6.47644304
7regulation of interleukin-13 production (GO:0032656)5.70586365
8sex differentiation (GO:0007548)5.68284183
9cerebellar Purkinje cell differentiation (GO:0021702)5.43386439
10centrosome duplication (GO:0051298)4.89933836
11nuclear pore complex assembly (GO:0051292)4.74481731
12regulation of interleukin-5 production (GO:0032674)4.59630646
13positive regulation of vasculogenesis (GO:2001214)4.59215855
14mitotic sister chromatid cohesion (GO:0007064)4.55183643
15cytoplasmic mRNA processing body assembly (GO:0033962)4.53002313
16sterol catabolic process (GO:0016127)4.52517453
17cholesterol catabolic process (GO:0006707)4.52517453
18phospholipid translocation (GO:0045332)4.49096753
19lipid translocation (GO:0034204)4.49096753
20negative regulation of cell killing (GO:0031342)4.06816875
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.06816875
22nuclear pore organization (GO:0006999)4.02323563
23regulation of RNA export from nucleus (GO:0046831)4.01842496
24nucleoside diphosphate catabolic process (GO:0009134)3.99282043
25pre-miRNA processing (GO:0031054)3.95810505
26positive regulation of histone deacetylation (GO:0031065)3.78346154
27phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.72720369
28negative regulation of receptor-mediated endocytosis (GO:0048261)3.66479172
29positive regulation of gamma-delta T cell activation (GO:0046645)3.65447612
30histone H3-K36 demethylation (GO:0070544)3.56456899
31pore complex assembly (GO:0046931)3.52908022
32regulation of transforming growth factor beta2 production (GO:0032909)3.51871238
33regulation of nucleobase-containing compound transport (GO:0032239)3.49950643
34acrosome assembly (GO:0001675)3.48643636
35positive regulation of fatty acid beta-oxidation (GO:0032000)3.47217653
36negative regulation of histone methylation (GO:0031061)3.47086019
37positive thymic T cell selection (GO:0045059)3.45700534
38interkinetic nuclear migration (GO:0022027)3.43967282
39regulation of fatty acid beta-oxidation (GO:0031998)3.41561123
40NLS-bearing protein import into nucleus (GO:0006607)3.40846375
41positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.35261315
42regulation of gamma-delta T cell differentiation (GO:0045586)3.35212088
43regulation of vasculogenesis (GO:2001212)3.23541936
44regulation of interleukin-12 biosynthetic process (GO:0045075)3.23269449
45regulation of metalloenzyme activity (GO:0048552)3.23268474
46growth hormone receptor signaling pathway (GO:0060396)3.22638281
47negative regulation of endothelial cell apoptotic process (GO:2000352)3.16117998
48negative T cell selection (GO:0043383)3.15479776
49negative thymic T cell selection (GO:0045060)3.11948086
50iron ion import (GO:0097286)3.08632133
51positive T cell selection (GO:0043368)3.05811767
52histone H3-K9 demethylation (GO:0033169)3.03913547
53regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.03896144
54regulation of gamma-delta T cell activation (GO:0046643)3.00055483
55glucocorticoid receptor signaling pathway (GO:0042921)2.98731975
56corticosteroid receptor signaling pathway (GO:0031958)2.96399422
57thymic T cell selection (GO:0045061)2.94625545
58regulation of protein polyubiquitination (GO:1902914)2.93777519
59histone lysine demethylation (GO:0070076)2.92750348
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.92037738
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.92037738
62negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.91958449
63negative regulation of translation, ncRNA-mediated (GO:0040033)2.91958449
64regulation of translation, ncRNA-mediated (GO:0045974)2.91958449
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.90738338
66peptidyl-lysine methylation (GO:0018022)2.89977343
67antigen processing and presentation of endogenous antigen (GO:0019883)2.89851206
68regulation of histone H3-K9 methylation (GO:0051570)2.89540300
69response to X-ray (GO:0010165)2.89288473
70ADP metabolic process (GO:0046031)2.88871180
71T cell selection (GO:0045058)2.88470672
72central nervous system projection neuron axonogenesis (GO:0021952)2.88171140
73histone H3-K4 trimethylation (GO:0080182)2.87325358
74lipid particle organization (GO:0034389)2.86213839
75heterochromatin organization (GO:0070828)2.85529204
76negative regulation of T cell differentiation (GO:0045581)2.83460148
77regulation of DNA endoreduplication (GO:0032875)2.82194779
78regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.81689845
79retrograde transport, vesicle recycling within Golgi (GO:0000301)2.79972086
80regulation of type 2 immune response (GO:0002828)2.78694533
81cellular response to growth hormone stimulus (GO:0071378)2.78068475
82histone deubiquitination (GO:0016578)2.78028631
83histone demethylation (GO:0016577)2.77955422
84actin cytoskeleton reorganization (GO:0031532)2.77256314
85import into cell (GO:0098657)2.74543813
86regulation of interferon-beta biosynthetic process (GO:0045357)2.74009513
87histone H3-K4 methylation (GO:0051568)2.72417684
88establishment of protein localization to Golgi (GO:0072600)2.68994743
89regulation of B cell receptor signaling pathway (GO:0050855)2.68539441
90protein K63-linked deubiquitination (GO:0070536)2.65174107
91protein targeting to Golgi (GO:0000042)2.64032128
92chromatin assembly (GO:0031497)2.62083002
93protein localization to endosome (GO:0036010)2.60691028
94mRNA stabilization (GO:0048255)2.58746924
95RNA stabilization (GO:0043489)2.58746924
96positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.58661209
97regulation of membrane lipid distribution (GO:0097035)2.58075213
98snRNA transcription (GO:0009301)2.55998690
99regulation of ARF GTPase activity (GO:0032312)2.55342169
100germ cell migration (GO:0008354)2.54464178
101regulation of T cell tolerance induction (GO:0002664)2.53595794
102embryonic process involved in female pregnancy (GO:0060136)2.53322542
103central nervous system neuron axonogenesis (GO:0021955)2.52405094
104negative regulation of organ growth (GO:0046621)2.51686331
105insulin-like growth factor receptor signaling pathway (GO:0048009)2.50818057
106regulation of protein deacetylation (GO:0090311)2.50076865
107regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.49713415
108positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.49713415
109negative regulation of keratinocyte proliferation (GO:0010839)2.49463245
110TOR signaling (GO:0031929)2.49114319
111peptidyl-threonine modification (GO:0018210)2.45763536
112regulation of sequestering of triglyceride (GO:0010889)2.45714840
113positive regulation of protein deacetylation (GO:0090312)2.45100042
114monoubiquitinated protein deubiquitination (GO:0035520)2.44560895
115positive regulation of mRNA catabolic process (GO:0061014)2.43335849
116cell differentiation in hindbrain (GO:0021533)2.42610005
117regulation of triglyceride catabolic process (GO:0010896)2.42364602
118peptidyl-threonine phosphorylation (GO:0018107)2.41593469
119positive regulation of mitotic sister chromatid separation (GO:1901970)2.41572593
120positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.41572593
121positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.41572593
122stress granule assembly (GO:0034063)2.40418399
123positive regulation of fatty acid oxidation (GO:0046321)2.39904684
124regulation of posttranscriptional gene silencing (GO:0060147)2.39735892
125regulation of gene silencing by miRNA (GO:0060964)2.39735892
126regulation of gene silencing by RNA (GO:0060966)2.39735892
127peptidyl-lysine trimethylation (GO:0018023)2.39644170
128regulation of mRNA catabolic process (GO:0061013)2.39551189
129positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.38759978
130regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.38759978
131regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.38650699
132histone mRNA catabolic process (GO:0071044)2.36823452
133protein demethylation (GO:0006482)2.36051563
134protein dealkylation (GO:0008214)2.36051563
135JAK-STAT cascade (GO:0007259)2.34873496
136peptidyl-lysine dimethylation (GO:0018027)2.33941010
137definitive hemopoiesis (GO:0060216)2.33496545
138negative regulation of endothelial cell proliferation (GO:0001937)2.33401240
139regulation of histone deacetylation (GO:0031063)2.31495246
140histone lysine methylation (GO:0034968)2.30897387
141protein K48-linked deubiquitination (GO:0071108)2.29997038
142B cell receptor signaling pathway (GO:0050853)2.29585444
143natural killer cell differentiation (GO:0001779)2.29184050
144neural tube formation (GO:0001841)2.28834582
145early endosome to late endosome transport (GO:0045022)2.28395506
146mitotic chromosome condensation (GO:0007076)2.28118088
147bile acid biosynthetic process (GO:0006699)2.27333060
148negative regulation of DNA repair (GO:0045738)2.27006376
149regulation of histone H3-K27 methylation (GO:0061085)2.26608278
150embryonic camera-type eye morphogenesis (GO:0048596)2.26458015
151Golgi to endosome transport (GO:0006895)2.24904425
152histone H3-K9 modification (GO:0061647)2.24801578
153regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.24449946
154indolalkylamine catabolic process (GO:0046218)2.24292115
155hepatocyte apoptotic process (GO:0097284)2.23918015
156JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.23128963
157histone H3-K9 methylation (GO:0051567)2.21835380
158NIK/NF-kappaB signaling (GO:0038061)2.20996595
159response to UV-C (GO:0010225)2.20954628
160negative regulation of B cell proliferation (GO:0030889)2.20927341
161response to interleukin-15 (GO:0070672)2.20779736
162embryonic hemopoiesis (GO:0035162)2.20573100
163protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.18877403
164negative regulation of histone modification (GO:0031057)2.18474162
165histone H4-K16 acetylation (GO:0043984)2.17458981
166regulation of B cell differentiation (GO:0045577)2.17390985
167trophectodermal cell differentiation (GO:0001829)2.17252269
168positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.15751727
169DNA topological change (GO:0006265)2.15433338
170hippo signaling (GO:0035329)2.14314969

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.87482615
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.30923844
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.27643721
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.21417644
5E2F7_22180533_ChIP-Seq_HELA_Human3.66646585
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.65582334
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.92345394
8MYC_22102868_ChIP-Seq_BL_Human2.89541286
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.80766861
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.58505240
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.49217142
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48833892
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.40149400
14* TCF7_22412390_ChIP-Seq_EML_Mouse2.36207667
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.34642838
16* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.27000284
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.24108315
18RUNX_20019798_ChIP-Seq_JUKART_Human2.14989127
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.12646200
20TAF15_26573619_Chip-Seq_HEK293_Human2.11513675
21* KDM2B_26808549_Chip-Seq_DND41_Human1.98259383
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88673053
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82751671
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.80812100
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76828303
26BCAT_22108803_ChIP-Seq_LS180_Human1.76120620
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75951375
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.74068230
29MAF_26560356_Chip-Seq_TH1_Human1.72399647
30MYB_26560356_Chip-Seq_TH2_Human1.72042992
31AHR_22903824_ChIP-Seq_MCF-7_Human1.70452846
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.70118825
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70082423
34MYB_26560356_Chip-Seq_TH1_Human1.66972496
35* VDR_21846776_ChIP-Seq_THP-1_Human1.66516042
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65252359
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63825472
38* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63059759
39ER_23166858_ChIP-Seq_MCF-7_Human1.60241013
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58285855
41* KDM2B_26808549_Chip-Seq_JURKAT_Human1.55723586
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.54761055
43UTX_26944678_Chip-Seq_JUKART_Human1.53916477
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.51539641
45* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51135034
46SCL_19346495_ChIP-Seq_HPC-7_Human1.49767937
47DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46559750
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45137523
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44257454
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43670890
51FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.43335606
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42945188
53TP53_16413492_ChIP-PET_HCT116_Human1.42929962
54STAT3_23295773_ChIP-Seq_U87_Human1.39739910
55FOXM1_26456572_ChIP-Seq_MCF-7_Human1.39631957
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39600772
57* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38444376
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38159179
59AR_21572438_ChIP-Seq_LNCaP_Human1.37201416
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.35743790
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33495076
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31709886
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31403759
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31089902
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30835245
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30265543
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29668783
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26958178
69KDM2B_26808549_Chip-Seq_REH_Human1.26836305
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26724249
71VDR_24763502_ChIP-Seq_THP-1_Human1.24197024
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23780649
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23486635
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22795675
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.22579671
76OCT1_27270436_Chip-Seq_PROSTATE_Human1.21986050
77SPI1_23127762_ChIP-Seq_K562_Human1.20964055
78* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19449373
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17629494
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.17332260
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16152099
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15921875
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15727546
84BRD4_25478319_ChIP-Seq_HGPS_Human1.14937512
85TCF4_23295773_ChIP-Seq_U87_Human1.14895337
86GATA1_22025678_ChIP-Seq_K562_Human1.14829396
87GATA3_27048872_Chip-Seq_THYMUS_Human1.14564555
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14469508
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13884609
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13493728
91IRF8_21731497_ChIP-ChIP_J774_Mouse1.13398512
92RXR_22108803_ChIP-Seq_LS180_Human1.12752555
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12637385
94FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12519764
95CLOCK_20551151_ChIP-Seq_293T_Human1.11888149
96* TP63_23658742_ChIP-Seq_EP156T_Human1.11684215
97VDR_24787735_ChIP-Seq_THP-1_Human1.11512595
98GBX2_23144817_ChIP-Seq_PC3_Human1.11417150
99DROSHA_22980978_ChIP-Seq_HELA_Human1.11327986
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10416389
101NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10228216
102FUS_26573619_Chip-Seq_HEK293_Human1.08910535
103VDR_22108803_ChIP-Seq_LS180_Human1.08458012
104CDX2_22108803_ChIP-Seq_LS180_Human1.06999005
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06679586
106KDM2B_26808549_Chip-Seq_K562_Human1.06444454
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05941167
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05863922
109* NCOR1_26117541_ChIP-Seq_K562_Human1.04865563
110RUNX1_22412390_ChIP-Seq_EML_Mouse1.03454908
111ELK3_25401928_ChIP-Seq_HUVEC_Human1.02596623
112NOTCH1_21737748_ChIP-Seq_TLL_Human1.02581061
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02494326
114FOXA2_19822575_ChIP-Seq_HepG2_Human1.02478727
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01802401
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01599414
117TP53_18474530_ChIP-ChIP_U2OS_Human1.01410021
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99496978
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99405749
120* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98983137
121PU_27001747_Chip-Seq_BMDM_Mouse0.98974816
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98071519
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98019647
124E2F1_21310950_ChIP-Seq_MCF-7_Human0.97369537
125TCF4_18268006_ChIP-ChIP_LS174T_Human0.97214333
126HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96956155
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96116723
128ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94998144
129IGF1R_20145208_ChIP-Seq_DFB_Human0.94753366
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94402752
131FLI1_27457419_Chip-Seq_LIVER_Mouse0.94399744
132* GATA6_25053715_ChIP-Seq_YYC3_Human0.93202726
133CDX2_20551321_ChIP-Seq_CACO-2_Human0.93130474
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92683356
135RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91496114
136RUNX1_27514584_Chip-Seq_MCF-7_Human0.91304376
137SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91267028
138SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91267028
139CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90770024
140ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90494760
141FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.90016948
142TP63_17297297_ChIP-ChIP_HaCaT_Human0.89463931
143GF1B_26923725_Chip-Seq_HPCs_Mouse0.89110085
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87804350
145POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87804350
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87572565
147* SMAD4_21799915_ChIP-Seq_A2780_Human0.87361405
148SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87007567
149CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86935653
150WT1_19549856_ChIP-ChIP_CCG9911_Human0.86796804
151EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86148174
152PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86100317
153STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85701236
154SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85410934
155* ISL1_27105846_Chip-Seq_CPCs_Mouse0.85022399

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.51842907
2MP0010352_gastrointestinal_tract_polyps3.50031267
3MP0000569_abnormal_digit_pigmentation3.26510068
4MP0005076_abnormal_cell_differentiation3.20600082
5MP0003705_abnormal_hypodermis_morpholog3.07528382
6MP0000371_diluted_coat_color2.73857989
7MP0002166_altered_tumor_susceptibility2.63510081
8MP0003303_peritoneal_inflammation2.48387761
9MP0010234_abnormal_vibrissa_follicle2.39652545
10MP0004130_abnormal_muscle_cell2.32449972
11MP0004381_abnormal_hair_follicle2.18867912
12MP0001986_abnormal_taste_sensitivity2.17735135
13MP0010307_abnormal_tumor_latency2.13007591
14MP0002006_tumorigenesis1.98616920
15MP0001800_abnormal_humoral_immune1.97733807
16MP0002009_preneoplasia1.95544001
17MP0004808_abnormal_hematopoietic_stem1.95027929
18MP0008057_abnormal_DNA_replication1.88626083
19MP0009278_abnormal_bone_marrow1.84932230
20MP0008961_abnormal_basal_metabolism1.83971300
21MP0005387_immune_system_phenotype1.82955423
22MP0001790_abnormal_immune_system1.82955423
23MP0003763_abnormal_thymus_physiology1.82665999
24MP0002396_abnormal_hematopoietic_system1.81364548
25MP0003172_abnormal_lysosome_physiology1.78803102
26MP0002877_abnormal_melanocyte_morpholog1.78776281
27MP0003091_abnormal_cell_migration1.75075367
28MP0004185_abnormal_adipocyte_glucose1.72190722
29MP0000685_abnormal_immune_system1.71878683
30MP0003566_abnormal_cell_adhesion1.71741485
31MP0003045_fibrosis1.71634249
32MP0001835_abnormal_antigen_presentation1.67350311
33MP0000427_abnormal_hair_cycle1.66704474
34MP0001873_stomach_inflammation1.63131371
35MP0000383_abnormal_hair_follicle1.60107658
36MP0000733_abnormal_muscle_development1.58387740
37MP0002254_reproductive_system_inflammat1.54832955
38MP0002452_abnormal_antigen_presenting1.53069817
39MP0005174_abnormal_tail_pigmentation1.52234803
40MP0002398_abnormal_bone_marrow1.51187670
41MP0003787_abnormal_imprinting1.48707977
42MP0003950_abnormal_plasma_membrane1.46764217
43MP0003943_abnormal_hepatobiliary_system1.45915289
44MP0004510_myositis1.45415376
45MP0000015_abnormal_ear_pigmentation1.44376661
46MP0000703_abnormal_thymus_morphology1.43974260
47MP0005275_abnormal_skin_tensile1.38285974
48MP0003011_delayed_dark_adaptation1.37742749
49MP0004197_abnormal_fetal_growth/weight/1.34955061
50MP0002420_abnormal_adaptive_immunity1.30347084
51MP0002138_abnormal_hepatobiliary_system1.29390855
52MP0002086_abnormal_extraembryonic_tissu1.29198373
53MP0001819_abnormal_immune_cell1.28828605
54MP0002723_abnormal_immune_serum1.27025316
55MP0004947_skin_inflammation1.26907746
56MP0003436_decreased_susceptibility_to1.24329284
57MP0005397_hematopoietic_system_phenotyp1.23146687
58MP0001545_abnormal_hematopoietic_system1.23146687
59MP0002088_abnormal_embryonic_growth/wei1.22485898
60MP0003984_embryonic_growth_retardation1.21565466
61MP0005647_abnormal_sex_gland1.19054247
62MP0000716_abnormal_immune_system1.19030098
63MP0003453_abnormal_keratinocyte_physiol1.18680688
64MP0005023_abnormal_wound_healing1.18235916
65MP0002075_abnormal_coat/hair_pigmentati1.17001515
66MP0001348_abnormal_lacrimal_gland1.14919480
67MP0002722_abnormal_immune_system1.14417703
68MP0002405_respiratory_system_inflammati1.14414888
69MP0005666_abnormal_adipose_tissue1.14354898
70MP0001661_extended_life_span1.13621269
71MP0000689_abnormal_spleen_morphology1.13317064
72MP0005671_abnormal_response_to1.12268386
73MP0009703_decreased_birth_body1.11747481
74MP0010155_abnormal_intestine_physiology1.11499086
75MP0001915_intracranial_hemorrhage1.11309907
76MP0005380_embryogenesis_phenotype1.10317488
77MP0001672_abnormal_embryogenesis/_devel1.10317488
78MP0005075_abnormal_melanosome_morpholog1.09925820
79MP0005000_abnormal_immune_tolerance1.09770617
80MP0005334_abnormal_fat_pad1.09340122
81MP0003828_pulmonary_edema1.09339420
82MP0002925_abnormal_cardiovascular_devel1.05863757
83MP0000767_abnormal_smooth_muscle1.05105100
84MP0010678_abnormal_skin_adnexa1.04833517
85MP0000350_abnormal_cell_proliferation1.04481552
86MP0009384_cardiac_valve_regurgitation1.03418673
87MP0000377_abnormal_hair_follicle1.03173897
88MP0002928_abnormal_bile_duct1.01472969
89MP0003252_abnormal_bile_duct1.01165703
90MP0003890_abnormal_embryonic-extraembry1.00072248
91MP0002108_abnormal_muscle_morphology0.99662702
92MP0002084_abnormal_developmental_patter0.99559595
93MP0001851_eye_inflammation0.98983060
94MP0000470_abnormal_stomach_morphology0.97814226
95MP0004264_abnormal_extraembryonic_tissu0.97566829
96MP0008877_abnormal_DNA_methylation0.96559235
97MP0002429_abnormal_blood_cell0.95879112
98MP0008438_abnormal_cutaneous_collagen0.95364232
99MP0000003_abnormal_adipose_tissue0.94951136
100MP0009053_abnormal_anal_canal0.94916906
101MP0009115_abnormal_fat_cell0.94743044
102MP0003868_abnormal_feces_composition0.94635526
103MP0003448_altered_tumor_morphology0.94189613
104MP0001730_embryonic_growth_arrest0.92732424
105MP0006054_spinal_hemorrhage0.90743111
106MP0003121_genomic_imprinting0.90530885
107MP0005375_adipose_tissue_phenotype0.89293767
108MP0000537_abnormal_urethra_morphology0.89205128
109MP0005623_abnormal_meninges_morphology0.87490176
110MP0003385_abnormal_body_wall0.86238530
111MP0002060_abnormal_skin_morphology0.85501585
112MP0010094_abnormal_chromosome_stability0.85161105
113MP0003077_abnormal_cell_cycle0.84169187
114MP0000428_abnormal_craniofacial_morphol0.83594921
115MP0002089_abnormal_postnatal_growth/wei0.83181711
116MP0000266_abnormal_heart_morphology0.82437566
117MP0003935_abnormal_craniofacial_develop0.82072970
118MP0002933_joint_inflammation0.81879234
119MP0009672_abnormal_birth_weight0.81427928
120MP0001186_pigmentation_phenotype0.81422496
121MP0001784_abnormal_fluid_regulation0.81354713
122MP0005248_abnormal_Harderian_gland0.80289310
123MP0005310_abnormal_salivary_gland0.79548524
124MP0009780_abnormal_chondrocyte_physiolo0.79203048
125MP0003115_abnormal_respiratory_system0.79056165
126MP0005083_abnormal_biliary_tract0.78961799
127MP0005409_darkened_coat_color0.78509440
128MP0010630_abnormal_cardiac_muscle0.76936686
129MP0002896_abnormal_bone_mineralization0.76865591
130MP0005621_abnormal_cell_physiology0.76446364
131MP0000432_abnormal_head_morphology0.76148362
132MP0002419_abnormal_innate_immunity0.75059696
133MP0002168_other_aberrant_phenotype0.74730989
134MP0001697_abnormal_embryo_size0.74619763
135MP0002085_abnormal_embryonic_tissue0.74578549
136MP0000465_gastrointestinal_hemorrhage0.72978308
137MP0005220_abnormal_exocrine_pancreas0.72125753
138MP0001191_abnormal_skin_condition0.70458684
139MP0003936_abnormal_reproductive_system0.70252673
140MP0003959_abnormal_lean_body0.70106442
141MP0005408_hypopigmentation0.69715561
142MP0002971_abnormal_brown_adipose0.68560492
143MP0001944_abnormal_pancreas_morphology0.64417990

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)8.39180224
2Action tremor (HP:0002345)6.20505785
3Progressive cerebellar ataxia (HP:0002073)5.38410743
4Prostate neoplasm (HP:0100787)5.28269360
5Slow saccadic eye movements (HP:0000514)4.98566007
6Abnormality of the fingertips (HP:0001211)4.21482063
7Gaze-evoked nystagmus (HP:0000640)4.14618067
8Urinary bladder sphincter dysfunction (HP:0002839)4.11788487
9Abnormality of the hepatic vasculature (HP:0006707)3.97924358
10Impaired vibratory sensation (HP:0002495)3.64004746
11Dysdiadochokinesis (HP:0002075)3.63875515
12Macroorchidism (HP:0000053)3.47960957
13Postural instability (HP:0002172)3.46399086
14Volvulus (HP:0002580)3.37291359
15Hypochromic microcytic anemia (HP:0004840)3.22027038
16Absence seizures (HP:0002121)3.04927591
17Heterotopia (HP:0002282)2.98132484
18Absent frontal sinuses (HP:0002688)2.81116243
19Postural tremor (HP:0002174)2.80299735
20Impaired smooth pursuit (HP:0007772)2.80178027
21Cerebral aneurysm (HP:0004944)2.77014213
22Limb ataxia (HP:0002070)2.65685800
23Hematochezia (HP:0002573)2.65540020
24Abnormality of the prostate (HP:0008775)2.60313361
25Long eyelashes (HP:0000527)2.56630830
26Recurrent viral infections (HP:0004429)2.47967532
27Mitral valve prolapse (HP:0001634)2.47680115
28T lymphocytopenia (HP:0005403)2.47249393
29Subacute progressive viral hepatitis (HP:0006572)2.47154145
30Short 4th metacarpal (HP:0010044)2.45006692
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.45006692
32Aortic aneurysm (HP:0004942)2.44236728
33Pendular nystagmus (HP:0012043)2.37425063
34Increased density of long bones (HP:0006392)2.34354194
35Abnormality of T cell number (HP:0011839)2.31979807
36Protruding tongue (HP:0010808)2.29565204
37Narrow palate (HP:0000189)2.28414574
38Relative macrocephaly (HP:0004482)2.28357879
39Abnormality of the nasal septum (HP:0000419)2.26202261
40Colitis (HP:0002583)2.25356272
41Impaired proprioception (HP:0010831)2.21539191
42Fair hair (HP:0002286)2.19789858
43Truncal obesity (HP:0001956)2.18066073
44Severe visual impairment (HP:0001141)2.15601867
45Abnormality of ocular smooth pursuit (HP:0000617)2.14822053
46Deviation of the thumb (HP:0009603)2.14041428
47Thyroiditis (HP:0100646)2.13764584
48Rectal prolapse (HP:0002035)2.10855727
49Spinal cord lesions (HP:0100561)2.09145859
50Syringomyelia (HP:0003396)2.09145859
51Dialeptic seizures (HP:0011146)2.07615303
52Shallow orbits (HP:0000586)2.06413188
53Hypoplastic ischia (HP:0003175)2.06190893
54Ulnar bowing (HP:0003031)2.04979604
55Recurrent fungal infections (HP:0002841)2.04315020
56Limited elbow extension (HP:0001377)2.01805412
57Hypochromic anemia (HP:0001931)2.00395831
58Proximal placement of thumb (HP:0009623)1.98906320
59Chromsome breakage (HP:0040012)1.98445617
60Hypoplastic iliac wings (HP:0002866)1.97859074
61Cutis marmorata (HP:0000965)1.96450238
62Abnormality of saccadic eye movements (HP:0000570)1.96379473
63Urethral obstruction (HP:0000796)1.96092520
64Dislocated radial head (HP:0003083)1.94458425
65Vitreoretinal degeneration (HP:0000655)1.93891939
66Ankyloglossia (HP:0010296)1.93387827
67Submucous cleft hard palate (HP:0000176)1.91969422
68Trigonocephaly (HP:0000243)1.89821961
69Myocardial infarction (HP:0001658)1.89613022
70Gingival bleeding (HP:0000225)1.89572393
71Biliary tract neoplasm (HP:0100574)1.88983025
72Inflammation of the large intestine (HP:0002037)1.87621831
73Deep philtrum (HP:0002002)1.87089985
74Curly hair (HP:0002212)1.86757993
75Viral hepatitis (HP:0006562)1.86272587
76Abnormality of vision evoked potentials (HP:0000649)1.86261068
77Overgrowth (HP:0001548)1.85148927
78Gastrointestinal carcinoma (HP:0002672)1.83254475
79Malignant gastrointestinal tract tumors (HP:0006749)1.83254475
80Increased nuchal translucency (HP:0010880)1.82770331
81Transitional cell carcinoma of the bladder (HP:0006740)1.82740276
82Vertebral arch anomaly (HP:0008438)1.82440562
83Abnormality of the radial head (HP:0003995)1.81119766
84Obsessive-compulsive behavior (HP:0000722)1.80953927
85Persistence of primary teeth (HP:0006335)1.80592184
86Papillary thyroid carcinoma (HP:0002895)1.80168154
87Prominent nose (HP:0000448)1.78823455
88Abnormal biliary tract morphology (HP:0012440)1.78781376
89Gastrointestinal inflammation (HP:0004386)1.78222243
90Disproportionate tall stature (HP:0001519)1.78177532
91Cellulitis (HP:0100658)1.77696989
92Enlarged penis (HP:0000040)1.77523726
93Increased mean platelet volume (HP:0011877)1.77418571
94Abnormality of the 4th metacarpal (HP:0010012)1.77408217
95Osteolytic defects of the phalanges of the hand (HP:0009771)1.76884173
96Osteolytic defects of the hand bones (HP:0009699)1.76884173
97Abnormal platelet volume (HP:0011876)1.76540128
98Papilloma (HP:0012740)1.76521132
99Verrucae (HP:0200043)1.76521132
100Aneurysm (HP:0002617)1.76060311
101Thickened helices (HP:0000391)1.75980702
102Areflexia of lower limbs (HP:0002522)1.73920171
103Facial hemangioma (HP:0000329)1.73793794
104Abnormality of the ischium (HP:0003174)1.73539372
105Agammaglobulinemia (HP:0004432)1.73369538
106Metaphyseal cupping (HP:0003021)1.73137197
107Hyperacusis (HP:0010780)1.73107872
108Thick eyebrow (HP:0000574)1.72535730
109Low anterior hairline (HP:0000294)1.72372564
110Genu recurvatum (HP:0002816)1.71996035
111Dilatation of the ascending aorta (HP:0005111)1.71608026
112Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71358737
113Broad thumb (HP:0011304)1.71028168
114Supernumerary ribs (HP:0005815)1.71018395
115Bladder carcinoma (HP:0002862)1.70179653
116Bladder neoplasm (HP:0009725)1.70179653
117Sandal gap (HP:0001852)1.69733717
118Spontaneous hematomas (HP:0007420)1.69329152
119Acute myeloid leukemia (HP:0004808)1.69002312
120Generalized hypopigmentation of hair (HP:0011358)1.67897087
121Micronodular cirrhosis (HP:0001413)1.67760381
122Recurrent bronchitis (HP:0002837)1.66303069
123Abnormality of male internal genitalia (HP:0000022)1.66137512
124IgA deficiency (HP:0002720)1.65686936
125Abnormal foot bone ossification (HP:0010675)1.65174594
126Broad palm (HP:0001169)1.64636964
127Periodontitis (HP:0000704)1.64192993
128Autoimmune thrombocytopenia (HP:0001973)1.64163813
129Tibial bowing (HP:0002982)1.63952907
130Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63487040
131Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63293491
132Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62469712
133Abnormality of the astrocytes (HP:0100707)1.62262046
134Astrocytoma (HP:0009592)1.62262046
135Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.61852886
136High pitched voice (HP:0001620)1.60598568
137Panhypogammaglobulinemia (HP:0003139)1.60077742
138Abnormality of DNA repair (HP:0003254)1.59976862
139Spondylolisthesis (HP:0003302)1.57364925
140Abnormality of the distal phalanx of the thumb (HP:0009617)1.57311663
141Amaurosis fugax (HP:0100576)1.56179588
142Abnormal delayed hypersensitivity skin test (HP:0002963)1.56000347
143Focal seizures (HP:0007359)1.54929371
144Broad ribs (HP:0000885)1.54666203
145Aortic dissection (HP:0002647)1.54614439
146Cutaneous melanoma (HP:0012056)1.54323290
147Skin tags (HP:0010609)1.53854026
148Dysmetric saccades (HP:0000641)1.53776141
149Severe Myopia (HP:0011003)1.53678642
150Arterial thrombosis (HP:0004420)1.52951963
151Basal cell carcinoma (HP:0002671)1.52919678
152Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.52452052
153Abnormality of the aortic arch (HP:0012303)1.52163650
154Portal hypertension (HP:0001409)1.51940573
155Hyperventilation (HP:0002883)1.51696344
156Abnormality of incisor morphology (HP:0011063)1.51598209
157Deep palmar crease (HP:0006191)1.50944330
158Hypoplastic ilia (HP:0000946)1.48123175
159Hip dysplasia (HP:0001385)1.47617762
160Deeply set eye (HP:0000490)1.46412133
161Ectopic kidney (HP:0000086)1.44858218
162Chest pain (HP:0100749)1.44226060
163Cubitus valgus (HP:0002967)1.43942116
164Flat acetabular roof (HP:0003180)1.43384818
165Pulmonic stenosis (HP:0001642)1.41638899
166Rhabdomyosarcoma (HP:0002859)1.40352941
167Abnormality of the epiphyses of the hand (HP:0005924)1.39282526
168Smooth philtrum (HP:0000319)1.35475182
169Abnormality of oral frenula (HP:0000190)1.34560120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK196.43165164
2CDK124.32001283
3OXSR13.62249634
4MAP3K102.78636334
5EEF2K2.47569824
6MAP4K12.38872594
7AKT32.37525145
8CAMK1D2.34720299
9CAMK1G2.20951850
10LATS11.92649603
11FGFR31.89470045
12STK101.80872039
13BRD41.80196753
14FRK1.78382088
15TNK21.75591772
16PKN21.73947625
17TRIB31.71944131
18JAK11.60528994
19RIPK11.60353217
20STK31.56238393
21DMPK1.52376133
22PTK61.51006860
23ACVR1B1.50940094
24MAP3K141.50297547
25SMG11.48689741
26TTN1.45471568
27GRK61.42106091
28MKNK21.40233420
29YES11.40169665
30CDK91.39135266
31CDK61.38308123
32ICK1.38196784
33MELK1.37578933
34SIK11.36830592
35SIK21.36692531
36FGFR21.35839466
37FGFR41.34522472
38PDGFRB1.32503140
39JAK31.29099721
40EPHB11.29094455
41CHUK1.25111139
42PRPF4B1.23962276
43CDC71.23670032
44MTOR1.21883695
45PDGFRA1.21713831
46CSK1.18815185
47NUAK11.18302422
48ITK1.17992372
49MAP3K21.17158527
50TYK21.15695713
51TAF11.08326236
52BMX1.05901790
53PIM11.04796539
54TGFBR21.01475192
55ALK1.01404138
56TBK11.01268981
57IRAK11.00498813
58SGK30.99613413
59NEK20.97777917
60CSF1R0.97770305
61STK40.97444837
62MAP3K130.96926646
63STK240.96683574
64IKBKE0.95771101
65IRAK20.95755605
66WNK10.92336727
67TXK0.91585327
68EPHA30.89255089
69CDK40.86386987
70MAP3K70.84496595
71TYRO30.83731159
72HCK0.83715748
73TAOK30.78047158
74STK380.76759936
75RPS6KA40.73792453
76IKBKB0.73190898
77BLK0.72326944
78RET0.72156715
79MAPK70.70865207
80MARK30.70845938
81HIPK20.70499495
82PRKCH0.69384576
83PRKAA20.68467001
84TGFBR10.67044963
85TRPM70.66582382
86SGK4940.65577180
87SGK2230.65577180
88PIK3CG0.64374391
89LRRK20.63235169
90RPS6KB10.63100547
91BTK0.61999224
92ATM0.61866308
93PDK10.61743824
94LCK0.61690710
95SCYL20.61217794
96RPS6KB20.61060598
97JAK20.61026155
98DDR20.60638516
99NEK60.59942968
100* CHEK10.59549122
101PDPK10.59512403
102MARK20.59324127
103STK110.58678338
104MKNK10.58631914
105DYRK1B0.57770851
106STK38L0.56366561
107MAP3K80.56326416
108CASK0.55863256
109TEC0.55823703
110ATR0.54893081
111RIPK40.54409705
112PRKCQ0.54376640
113PAK20.53910856
114SGK20.53360736
115NEK90.53244574
116FER0.52929316
117PRKD20.51948086
118MST1R0.50979848
119BMPR1B0.50879480
120FGFR10.50152238
121SGK10.50139545
122ZAP700.49830648
123CSNK1D0.49239866
124ERN10.48775647
125INSR0.48568589
126PRKD30.48177997
127MAP2K30.48123713
128MAPK110.47540311
129KSR20.47056463
130FLT30.45575919
131NLK0.44373955
132EIF2AK30.43292782
133CDK20.42969953
134FGR0.42070906
135PIK3CA0.41482808
136MAPK10.41257244
137PRKAA10.36920674
138CHEK20.36435577
139CDK30.35324642
140AKT10.35050001
141ERBB20.34327280
142ZAK0.34092748
143MET0.30637337

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.98158911
2B cell receptor signaling pathway_Homo sapiens_hsa046622.05843549
3Lysine degradation_Homo sapiens_hsa003101.74933319
4NF-kappa B signaling pathway_Homo sapiens_hsa040641.72110737
5Primary immunodeficiency_Homo sapiens_hsa053401.71469203
6Chronic myeloid leukemia_Homo sapiens_hsa052201.68131745
7T cell receptor signaling pathway_Homo sapiens_hsa046601.66276008
8Osteoclast differentiation_Homo sapiens_hsa043801.60936210
9Adherens junction_Homo sapiens_hsa045201.49221238
10mTOR signaling pathway_Homo sapiens_hsa041501.49074536
11Dorso-ventral axis formation_Homo sapiens_hsa043201.46203919
12Pancreatic cancer_Homo sapiens_hsa052121.45414790
13MicroRNAs in cancer_Homo sapiens_hsa052061.45158823
14Small cell lung cancer_Homo sapiens_hsa052221.38026085
15Measles_Homo sapiens_hsa051621.36521531
16Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30055646
17Toxoplasmosis_Homo sapiens_hsa051451.29509252
18Antigen processing and presentation_Homo sapiens_hsa046121.29357795
19Non-homologous end-joining_Homo sapiens_hsa034501.29356660
20Acute myeloid leukemia_Homo sapiens_hsa052211.27967778
21Fatty acid biosynthesis_Homo sapiens_hsa000611.22727233
22Viral myocarditis_Homo sapiens_hsa054161.22592849
23Viral carcinogenesis_Homo sapiens_hsa052031.21911756
24Proteoglycans in cancer_Homo sapiens_hsa052051.21803200
25Type II diabetes mellitus_Homo sapiens_hsa049301.19872770
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19393251
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17005158
28Leishmaniasis_Homo sapiens_hsa051401.16911357
29Hepatitis B_Homo sapiens_hsa051611.16862033
30Non-small cell lung cancer_Homo sapiens_hsa052231.16506638
31Systemic lupus erythematosus_Homo sapiens_hsa053221.15454980
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14911315
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14342701
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13264142
35Colorectal cancer_Homo sapiens_hsa052101.12910102
36Prostate cancer_Homo sapiens_hsa052151.11867201
37Endometrial cancer_Homo sapiens_hsa052131.11729414
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10377038
39Herpes simplex infection_Homo sapiens_hsa051681.08508988
40Focal adhesion_Homo sapiens_hsa045101.07889363
41Insulin resistance_Homo sapiens_hsa049311.07425658
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.07340566
43TNF signaling pathway_Homo sapiens_hsa046681.06475099
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05337405
45Melanoma_Homo sapiens_hsa052181.04984573
46Platelet activation_Homo sapiens_hsa046111.04045489
47HTLV-I infection_Homo sapiens_hsa051661.03895146
48Hematopoietic cell lineage_Homo sapiens_hsa046401.02345484
49Glioma_Homo sapiens_hsa052141.01521858
50Influenza A_Homo sapiens_hsa051641.01149879
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00940936
52FoxO signaling pathway_Homo sapiens_hsa040681.00340401
53Chemokine signaling pathway_Homo sapiens_hsa040621.00311795
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.00110284
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.99055939
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98159144
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97374837
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97244952
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.96513140
60Prolactin signaling pathway_Homo sapiens_hsa049170.95250425
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.95093307
62Circadian rhythm_Homo sapiens_hsa047100.91621899
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90378941
64Renal cell carcinoma_Homo sapiens_hsa052110.87897339
65Apoptosis_Homo sapiens_hsa042100.87033975
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86827822
67VEGF signaling pathway_Homo sapiens_hsa043700.86063223
68Notch signaling pathway_Homo sapiens_hsa043300.85224731
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85174024
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85076150
71Estrogen signaling pathway_Homo sapiens_hsa049150.84943884
72Inositol phosphate metabolism_Homo sapiens_hsa005620.82570124
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82509475
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80686934
75TGF-beta signaling pathway_Homo sapiens_hsa043500.80263651
76mRNA surveillance pathway_Homo sapiens_hsa030150.80098123
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79407257
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79307753
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79108749
80ECM-receptor interaction_Homo sapiens_hsa045120.76932457
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76310434
82MAPK signaling pathway_Homo sapiens_hsa040100.75212588
83Hepatitis C_Homo sapiens_hsa051600.75079923
84ErbB signaling pathway_Homo sapiens_hsa040120.74704689
85Pathways in cancer_Homo sapiens_hsa052000.74461132
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.74444862
87GnRH signaling pathway_Homo sapiens_hsa049120.74196956
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74090639
89Nitrogen metabolism_Homo sapiens_hsa009100.73756412
90AMPK signaling pathway_Homo sapiens_hsa041520.72303290
91Choline metabolism in cancer_Homo sapiens_hsa052310.72213745
92Amoebiasis_Homo sapiens_hsa051460.70554845
93Tuberculosis_Homo sapiens_hsa051520.68433752
94Rap1 signaling pathway_Homo sapiens_hsa040150.67841429
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65594767
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65114146
97Hippo signaling pathway_Homo sapiens_hsa043900.63968745
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.62813331
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.62606814
100Alcoholism_Homo sapiens_hsa050340.61935820
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61622009
102ABC transporters_Homo sapiens_hsa020100.61559375
103Ras signaling pathway_Homo sapiens_hsa040140.61315139
104HIF-1 signaling pathway_Homo sapiens_hsa040660.61245639
105Sphingolipid metabolism_Homo sapiens_hsa006000.60943747
106Ether lipid metabolism_Homo sapiens_hsa005650.60797169
107Long-term depression_Homo sapiens_hsa047300.60555603
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.59963692
109Cell cycle_Homo sapiens_hsa041100.59724186
110Shigellosis_Homo sapiens_hsa051310.57648256
111Salmonella infection_Homo sapiens_hsa051320.55321101
112Bladder cancer_Homo sapiens_hsa052190.54528879
113Insulin signaling pathway_Homo sapiens_hsa049100.54438789
114Hedgehog signaling pathway_Homo sapiens_hsa043400.53926489
115Wnt signaling pathway_Homo sapiens_hsa043100.53800802
116Renin secretion_Homo sapiens_hsa049240.53052079
117Basal cell carcinoma_Homo sapiens_hsa052170.52740558
118Thyroid cancer_Homo sapiens_hsa052160.52469318
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50992026
120Staphylococcus aureus infection_Homo sapiens_hsa051500.50631190
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.48229812
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47337429
123p53 signaling pathway_Homo sapiens_hsa041150.45297567

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