CDK14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.25815411
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.89309497
3neuron cell-cell adhesion (GO:0007158)4.88961942
4vocalization behavior (GO:0071625)4.86073970
5locomotory exploration behavior (GO:0035641)4.73283574
6synaptic vesicle exocytosis (GO:0016079)4.70518670
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.70319497
8synaptic vesicle maturation (GO:0016188)4.60722147
9regulation of glutamate receptor signaling pathway (GO:1900449)4.56403988
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.43912566
11glutamate secretion (GO:0014047)4.43770885
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.42029612
13sodium ion export (GO:0071436)4.36803427
14protein localization to synapse (GO:0035418)4.36102549
15regulation of synaptic vesicle exocytosis (GO:2000300)4.24687650
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.16173744
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.07401708
18cerebellar granule cell differentiation (GO:0021707)4.07399700
19neuronal action potential propagation (GO:0019227)4.01953151
20exploration behavior (GO:0035640)4.01813507
21glutamate receptor signaling pathway (GO:0007215)3.93615856
22regulation of synaptic vesicle transport (GO:1902803)3.81855564
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.75280916
24neuron recognition (GO:0008038)3.74812374
25presynaptic membrane assembly (GO:0097105)3.72071299
26regulation of neuronal synaptic plasticity (GO:0048168)3.70990231
27synaptic transmission, glutamatergic (GO:0035249)3.68885901
28positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.68272961
29synaptic vesicle endocytosis (GO:0048488)3.60645467
30postsynaptic membrane organization (GO:0001941)3.60092716
31neurotransmitter secretion (GO:0007269)3.59101263
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.58597826
33cell communication by electrical coupling (GO:0010644)3.57078269
34negative regulation of synaptic transmission, GABAergic (GO:0032229)3.56350443
35dendritic spine morphogenesis (GO:0060997)3.56051066
36neuron-neuron synaptic transmission (GO:0007270)3.51854488
37axonal fasciculation (GO:0007413)3.49419517
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.45899900
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38041911
40regulation of voltage-gated calcium channel activity (GO:1901385)3.37809682
41pyrimidine nucleobase catabolic process (GO:0006208)3.36736387
42L-amino acid import (GO:0043092)3.33225732
43regulation of postsynaptic membrane potential (GO:0060078)3.32653625
44presynaptic membrane organization (GO:0097090)3.32490548
45regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.30819944
46neurotransmitter-gated ion channel clustering (GO:0072578)3.24800038
47long-term memory (GO:0007616)3.23785192
48proline transport (GO:0015824)3.23650273
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.22702417
50long-term synaptic potentiation (GO:0060291)3.18553175
51startle response (GO:0001964)3.18281176
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.17715187
53transmission of nerve impulse (GO:0019226)3.16058240
54neurotransmitter transport (GO:0006836)3.13791902
55regulation of neurotransmitter secretion (GO:0046928)3.11924004
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.11906768
57short-term memory (GO:0007614)3.09433456
58layer formation in cerebral cortex (GO:0021819)3.09185439
59neuromuscular process controlling balance (GO:0050885)3.08459069
60dendrite morphogenesis (GO:0048813)3.06685208
61positive regulation of membrane potential (GO:0045838)3.06545545
62cellular sodium ion homeostasis (GO:0006883)3.06141188
63innervation (GO:0060384)3.05444584
64regulation of synaptic plasticity (GO:0048167)3.04957833
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.04011469
66regulation of vesicle fusion (GO:0031338)3.03244029
67regulation of synapse structural plasticity (GO:0051823)3.03217789
68cerebellar Purkinje cell differentiation (GO:0021702)3.03195274
69auditory behavior (GO:0031223)2.98028287
70membrane depolarization (GO:0051899)2.97107799
71establishment of mitochondrion localization (GO:0051654)2.96889595
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96680717
73positive regulation of dendritic spine morphogenesis (GO:0061003)2.93675448
74potassium ion homeostasis (GO:0055075)2.92989927
75behavioral response to cocaine (GO:0048148)2.90390213
76membrane depolarization during action potential (GO:0086010)2.90143078
77axon extension (GO:0048675)2.89173403
78chemosensory behavior (GO:0007635)2.88543328
79gamma-aminobutyric acid transport (GO:0015812)2.87597809
80positive regulation of synapse assembly (GO:0051965)2.87455052
81regulation of respiratory system process (GO:0044065)2.87196390
82synapse assembly (GO:0007416)2.86204214
83potassium ion import (GO:0010107)2.83168867
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81199067
85regulation of neurotransmitter transport (GO:0051588)2.80823989
86learning (GO:0007612)2.80030604
87regulation of dendritic spine morphogenesis (GO:0061001)2.79706612
88regulation of ARF protein signal transduction (GO:0032012)2.78776257
89regulation of neurotransmitter levels (GO:0001505)2.78496040
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.78381094
91righting reflex (GO:0060013)2.78213981
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.76808220
93behavioral fear response (GO:0001662)2.76323608
94behavioral defense response (GO:0002209)2.76323608
95neuronal ion channel clustering (GO:0045161)2.75711477
96positive regulation of neurotransmitter secretion (GO:0001956)2.75658440
97detection of calcium ion (GO:0005513)2.75497402
98mechanosensory behavior (GO:0007638)2.75382486
99regulation of respiratory gaseous exchange (GO:0043576)2.75174513
100regulation of synaptic transmission, GABAergic (GO:0032228)2.74830617
101dendritic spine organization (GO:0097061)2.73879925
102cellular potassium ion homeostasis (GO:0030007)2.73018526
103regulation of synapse assembly (GO:0051963)2.72956033
104negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72805505
105suckling behavior (GO:0001967)2.71937134
106response to auditory stimulus (GO:0010996)2.71025877
107negative regulation of dendrite development (GO:2000171)2.71009693
108central nervous system projection neuron axonogenesis (GO:0021952)2.70887785
109cell communication involved in cardiac conduction (GO:0086065)2.70219707
110amino acid import (GO:0043090)2.69289133
111positive regulation of synaptic transmission (GO:0050806)2.69077623
112mating behavior (GO:0007617)2.68871388
113regulation of synaptic transmission (GO:0050804)2.68110196
114establishment of nucleus localization (GO:0040023)2.68030130
115synaptic transmission (GO:0007268)2.66905761
116regulation of dendritic spine development (GO:0060998)2.65486909
117synaptic vesicle transport (GO:0048489)2.62541570
118establishment of synaptic vesicle localization (GO:0097480)2.62541570
119activation of protein kinase A activity (GO:0034199)2.61951399
120response to histamine (GO:0034776)2.61850531
121vesicle transport along microtubule (GO:0047496)2.61684674
122membrane hyperpolarization (GO:0060081)2.60044521
123adult walking behavior (GO:0007628)2.59346948
124positive regulation of neurotransmitter transport (GO:0051590)2.56154320
125cell migration in hindbrain (GO:0021535)2.55806982
126positive regulation of dendritic spine development (GO:0060999)2.55342968
127negative regulation of dendrite morphogenesis (GO:0050774)2.54249393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.43026135
2GBX2_23144817_ChIP-Seq_PC3_Human3.95397114
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96009489
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93466568
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87411007
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59359170
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56144291
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55224806
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55224806
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43533380
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.43113946
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.40980401
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37556179
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24112775
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22274857
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19353022
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14364202
18REST_21632747_ChIP-Seq_MESCs_Mouse2.14326473
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06190919
20DROSHA_22980978_ChIP-Seq_HELA_Human2.05566201
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.04636985
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00104260
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.99171691
24TAF15_26573619_Chip-Seq_HEK293_Human1.90086460
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85924959
26SMAD4_21799915_ChIP-Seq_A2780_Human1.79771208
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79181423
28AR_21572438_ChIP-Seq_LNCaP_Human1.78333770
29* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76361072
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74572401
31* P300_19829295_ChIP-Seq_ESCs_Human1.72138895
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69856793
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69569090
34IGF1R_20145208_ChIP-Seq_DFB_Human1.69048300
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67552023
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67155755
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.66053510
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64531431
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.63713837
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.62317042
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61606563
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59913354
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59043355
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.54333480
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.54320341
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.54052953
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53683410
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47433064
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.44683086
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.44590957
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43805026
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43227963
53* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41755936
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40792095
55* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39850538
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38096691
57STAT3_23295773_ChIP-Seq_U87_Human1.35454963
58* AR_25329375_ChIP-Seq_VCAP_Human1.34072325
59RNF2_27304074_Chip-Seq_NSC_Mouse1.33948891
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33588360
61* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32809932
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32806676
63FUS_26573619_Chip-Seq_HEK293_Human1.30290057
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30203974
65ZNF274_21170338_ChIP-Seq_K562_Hela1.30050884
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29697529
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27681033
68LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27581294
69* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27474107
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.27154661
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26805844
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26526483
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.24082368
74TP53_18474530_ChIP-ChIP_U2OS_Human1.20724100
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.20013519
76TCF4_23295773_ChIP-Seq_U87_Human1.19660544
77AHR_22903824_ChIP-Seq_MCF-7_Human1.19563526
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19393361
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17352236
80SOX9_26525672_Chip-Seq_HEART_Mouse1.16575557
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16319385
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16319385
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14799141
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14685102
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14484459
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.14401398
87* ER_23166858_ChIP-Seq_MCF-7_Human1.14400540
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13817947
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.13593377
90* RUNX2_22187159_ChIP-Seq_PCA_Human1.13523473
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13171664
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11159780
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11159780
94TP53_16413492_ChIP-PET_HCT116_Human1.10667351
95AR_19668381_ChIP-Seq_PC3_Human1.10010579
96P53_22387025_ChIP-Seq_ESCs_Mouse1.08704330
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08369422
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07921674
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07723050
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07446175
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07343464
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.07244534
103* KDM2B_26808549_Chip-Seq_REH_Human1.06992616
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.06696332
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06374898
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04259457
107FLI1_27457419_Chip-Seq_LIVER_Mouse1.03903364
108* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03092862
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03064232
110WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02819563
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02736677
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.01640495
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.01285088
114SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00057277
115P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99476392
116JUN_21703547_ChIP-Seq_K562_Human0.99128038
117VDR_22108803_ChIP-Seq_LS180_Human0.99012598
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98709101
119SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98273151
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96644765

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.58993399
2MP0003880_abnormal_central_pattern5.29803844
3MP0003635_abnormal_synaptic_transmissio3.66023101
4MP0004270_analgesia3.14376180
5MP0009745_abnormal_behavioral_response3.09682711
6MP0009046_muscle_twitch2.96880097
7MP0001968_abnormal_touch/_nociception2.92281522
8MP0002063_abnormal_learning/memory/cond2.91814662
9MP0002064_seizures2.89911525
10MP0000569_abnormal_digit_pigmentation2.73254806
11MP0002735_abnormal_chemical_nociception2.63174159
12MP0002572_abnormal_emotion/affect_behav2.62813076
13MP0005423_abnormal_somatic_nervous2.53547450
14MP0001486_abnormal_startle_reflex2.52256641
15MP0002734_abnormal_mechanical_nocicepti2.48863041
16MP0002272_abnormal_nervous_system2.41074427
17MP0006276_abnormal_autonomic_nervous2.39722933
18MP0001501_abnormal_sleep_pattern2.37106925
19MP0002736_abnormal_nociception_after2.34655100
20MP0001440_abnormal_grooming_behavior2.12977625
21MP0002067_abnormal_sensory_capabilities2.00537200
22MP0000778_abnormal_nervous_system1.95396506
23MP0003787_abnormal_imprinting1.92604427
24MP0001188_hyperpigmentation1.91526408
25MP0002733_abnormal_thermal_nociception1.89358395
26MP0001970_abnormal_pain_threshold1.86131556
27MP0002184_abnormal_innervation1.84540933
28MP0005646_abnormal_pituitary_gland1.75226201
29MP0002557_abnormal_social/conspecific_i1.74724399
30MP0005645_abnormal_hypothalamus_physiol1.70579586
31MP0010386_abnormal_urinary_bladder1.60795414
32MP0004858_abnormal_nervous_system1.56957278
33MP0003122_maternal_imprinting1.54189428
34MP0009780_abnormal_chondrocyte_physiolo1.52977808
35MP0008569_lethality_at_weaning1.51786759
36MP0004742_abnormal_vestibular_system1.50377000
37MP0001905_abnormal_dopamine_level1.47812373
38MP0000955_abnormal_spinal_cord1.47092958
39MP0004811_abnormal_neuron_physiology1.47082627
40MP0005386_behavior/neurological_phenoty1.46761947
41MP0004924_abnormal_behavior1.46761947
42MP0002882_abnormal_neuron_morphology1.39774327
43MP0005171_absent_coat_pigmentation1.39074745
44MP0001984_abnormal_olfaction1.33766630
45MP0001502_abnormal_circadian_rhythm1.33529518
46MP0003879_abnormal_hair_cell1.28789165
47MP0002066_abnormal_motor_capabilities/c1.27087893
48MP0008438_abnormal_cutaneous_collagen1.26283068
49MP0004142_abnormal_muscle_tone1.25143432
50MP0005409_darkened_coat_color1.23453822
51MP0002822_catalepsy1.19711189
52MP0001958_emphysema1.16175886
53MP0003123_paternal_imprinting1.15629803
54MP0000462_abnormal_digestive_system1.13652392
55MP0002909_abnormal_adrenal_gland1.12923747
56MP0005187_abnormal_penis_morphology1.10162632
57MP0001529_abnormal_vocalization1.07868832
58MP0003890_abnormal_embryonic-extraembry1.07314781
59MP0000566_synostosis1.06580856
60MP0003633_abnormal_nervous_system1.05864458
61MP0000015_abnormal_ear_pigmentation1.03295743
62MP0005503_abnormal_tendon_morphology1.00738020
63MP0005551_abnormal_eye_electrophysiolog1.00620493
64MP0005248_abnormal_Harderian_gland1.00404168
65MP0001963_abnormal_hearing_physiology1.00346090
66MP0003861_abnormal_nervous_system0.99690036
67MP0003329_amyloid_beta_deposits0.97108801
68MP0002152_abnormal_brain_morphology0.95995596
69MP0003631_nervous_system_phenotype0.95983878
70MP0001177_atelectasis0.95951225
71MP0003172_abnormal_lysosome_physiology0.94891878
72MP0004885_abnormal_endolymph0.94099448
73MP0002102_abnormal_ear_morphology0.94036030
74MP0000579_abnormal_nail_morphology0.92765501
75MP0000534_abnormal_ureter_morphology0.91852908
76MP0003283_abnormal_digestive_organ0.90096245
77MP0002752_abnormal_somatic_nervous0.88646809
78MP0003385_abnormal_body_wall0.88353600
79MP0002638_abnormal_pupillary_reflex0.88048571
80MP0002229_neurodegeneration0.87950701
81MP0003634_abnormal_glial_cell0.86539677
82MP0002233_abnormal_nose_morphology0.84715990
83MP0004510_myositis0.83922823
84MP0004145_abnormal_muscle_electrophysio0.83660247
85MP0003091_abnormal_cell_migration0.83569982
86MP0000631_abnormal_neuroendocrine_gland0.82226509
87MP0001299_abnormal_eye_distance/0.80178568
88MP0005275_abnormal_skin_tensile0.79482710
89MP0002876_abnormal_thyroid_physiology0.78768428
90MP0000026_abnormal_inner_ear0.78117924
91MP0000428_abnormal_craniofacial_morphol0.78064118
92MP0005623_abnormal_meninges_morphology0.77799718
93MP0003690_abnormal_glial_cell0.77679852
94MP0004484_altered_response_of0.76187854
95MP0000751_myopathy0.75531520
96MP0000920_abnormal_myelination0.75452258
97MP0003632_abnormal_nervous_system0.74416639
98MP0002069_abnormal_eating/drinking_beha0.74176660
99MP0002081_perinatal_lethality0.71809664
100MP0005394_taste/olfaction_phenotype0.71584394
101MP0005499_abnormal_olfactory_system0.71584394
102MP0002082_postnatal_lethality0.71153706
103MP0010770_preweaning_lethality0.71153706
104MP0010769_abnormal_survival0.69911815
105MP0003755_abnormal_palate_morphology0.69720749
106MP0003942_abnormal_urinary_system0.69707279
107MP0000537_abnormal_urethra_morphology0.67826718
108MP0002751_abnormal_autonomic_nervous0.67751603
109MP0003705_abnormal_hypodermis_morpholog0.67748013
110MP0006292_abnormal_olfactory_placode0.67562229
111MP0005535_abnormal_body_temperature0.67373714
112MP0010768_mortality/aging0.64499822
113MP0003935_abnormal_craniofacial_develop0.63976553
114MP0004085_abnormal_heartbeat0.63590588
115MP0009250_abnormal_appendicular_skeleto0.62183233
116MP0001485_abnormal_pinna_reflex0.61684278
117MP0005174_abnormal_tail_pigmentation0.60785095
118MP0003183_abnormal_peptide_metabolism0.59980359
119MP0002090_abnormal_vision0.59851188
120MP0001986_abnormal_taste_sensitivity0.59292319
121MP0001943_abnormal_respiration0.58618109
122MP0003136_yellow_coat_color0.58537046
123MP0003938_abnormal_ear_development0.58405662
124MP0005379_endocrine/exocrine_gland_phen0.58381614
125MP0008874_decreased_physiological_sensi0.57946292
126MP0003121_genomic_imprinting0.57318345
127MP0001664_abnormal_digestion0.56325273
128MP0005253_abnormal_eye_physiology0.51292581

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.32120703
2Febrile seizures (HP:0002373)5.31759905
3Focal seizures (HP:0007359)5.29408639
4Myokymia (HP:0002411)5.00616123
5Atonic seizures (HP:0010819)4.56622781
6Epileptic encephalopathy (HP:0200134)4.45292914
7Visual hallucinations (HP:0002367)4.21560527
8Progressive cerebellar ataxia (HP:0002073)4.14734126
9Absence seizures (HP:0002121)3.58429189
10Supranuclear gaze palsy (HP:0000605)3.54785430
11Generalized tonic-clonic seizures (HP:0002069)3.51212028
12Dialeptic seizures (HP:0011146)3.45747974
13Action tremor (HP:0002345)3.19665941
14Broad-based gait (HP:0002136)3.19193252
15Gaze-evoked nystagmus (HP:0000640)2.99567947
16Absent speech (HP:0001344)2.93408437
17Progressive inability to walk (HP:0002505)2.86913373
18Excessive salivation (HP:0003781)2.86513754
19Drooling (HP:0002307)2.86513754
20Amblyopia (HP:0000646)2.76165802
21Megalencephaly (HP:0001355)2.73451752
22Hyperventilation (HP:0002883)2.71652158
23Truncal ataxia (HP:0002078)2.60826357
24Mutism (HP:0002300)2.57712767
25Postural instability (HP:0002172)2.56710009
26Limb dystonia (HP:0002451)2.52344995
27Mild short stature (HP:0003502)2.51481603
28Dysdiadochokinesis (HP:0002075)2.49201873
29Hammertoe (HP:0001765)2.45504714
30Impaired vibration sensation in the lower limbs (HP:0002166)2.45311016
31Abnormal eating behavior (HP:0100738)2.45106275
32Dysmetria (HP:0001310)2.44924128
33Urinary bladder sphincter dysfunction (HP:0002839)2.44814573
34Overgrowth (HP:0001548)2.44225383
35Depression (HP:0000716)2.42939189
36Obstructive sleep apnea (HP:0002870)2.42346714
37Ankle clonus (HP:0011448)2.38558939
38Papilledema (HP:0001085)2.37356269
39Abnormality of the lower motor neuron (HP:0002366)2.35744577
40Protruding tongue (HP:0010808)2.30594420
41Fetal akinesia sequence (HP:0001989)2.29707647
42Anxiety (HP:0000739)2.28899290
43Hypsarrhythmia (HP:0002521)2.28816896
44Abnormal ciliary motility (HP:0012262)2.25077438
45Hemiparesis (HP:0001269)2.24031907
46Abnormality of salivation (HP:0100755)2.21935133
47Lower limb amyotrophy (HP:0007210)2.21233021
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.21145231
49Absent/shortened dynein arms (HP:0200106)2.21145231
50Blue irides (HP:0000635)2.20645130
51Neonatal short-limb short stature (HP:0008921)2.20024369
52Hypothermia (HP:0002045)2.19210497
53Thickened helices (HP:0000391)2.16058793
54Genetic anticipation (HP:0003743)2.14947781
55Cortical dysplasia (HP:0002539)2.14118751
56Agitation (HP:0000713)2.13763928
57Intention tremor (HP:0002080)2.13236002
58Hepatoblastoma (HP:0002884)2.11964810
59Sleep apnea (HP:0010535)2.11615789
60Turricephaly (HP:0000262)2.09466248
61Inability to walk (HP:0002540)2.09410704
62Exotropia (HP:0000577)2.09313937
63Abnormality of binocular vision (HP:0011514)2.02471446
64Diplopia (HP:0000651)2.02471446
65Aplasia of the phalanges of the hand (HP:0009802)1.99464903
66Aplasia involving bones of the extremities (HP:0009825)1.99464903
67Aplasia involving bones of the upper limbs (HP:0009823)1.99464903
68Apathy (HP:0000741)1.99257923
69Bradykinesia (HP:0002067)1.98357505
70Hypoventilation (HP:0002791)1.98339917
71Akinesia (HP:0002304)1.98143220
72Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.98081596
73Polyphagia (HP:0002591)1.97903419
74Vertebral arch anomaly (HP:0008438)1.97590532
75Scanning speech (HP:0002168)1.96318521
76Aqueductal stenosis (HP:0002410)1.95805382
77Atrophic scars (HP:0001075)1.92237033
78Dysmetric saccades (HP:0000641)1.92086088
79Poor eye contact (HP:0000817)1.91641072
80Neurofibrillary tangles (HP:0002185)1.91376652
81Gait imbalance (HP:0002141)1.90836326
82Stereotypic behavior (HP:0000733)1.90697071
83Status epilepticus (HP:0002133)1.89761658
84Epileptiform EEG discharges (HP:0011182)1.88848057
85Widely spaced teeth (HP:0000687)1.86805847
86Esotropia (HP:0000565)1.86520944
87Impaired smooth pursuit (HP:0007772)1.86305777
88Bradycardia (HP:0001662)1.85494678
89Shallow orbits (HP:0000586)1.84908766
90Retinal dysplasia (HP:0007973)1.84390414
91Broad metatarsal (HP:0001783)1.84332950
92Lower limb muscle weakness (HP:0007340)1.84190659
93Abnormal hair whorl (HP:0010721)1.84168168
94Arterial tortuosity (HP:0005116)1.83520207
95Abnormality of the corticospinal tract (HP:0002492)1.82208350
96Abnormal respiratory motile cilium physiology (HP:0012261)1.80635404
97Vascular tortuosity (HP:0004948)1.80326393
98Spastic gait (HP:0002064)1.78610773
99Cubitus valgus (HP:0002967)1.78162190
100Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77900302
101Inappropriate behavior (HP:0000719)1.77897723
102Cerebral inclusion bodies (HP:0100314)1.77170920
103Papillary thyroid carcinoma (HP:0002895)1.76350459
104Degeneration of the lateral corticospinal tracts (HP:0002314)1.74856442
105Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74856442
106Morphological abnormality of the pyramidal tract (HP:0002062)1.74799122
107Narrow nasal bridge (HP:0000446)1.74461183
108Specific learning disability (HP:0001328)1.73366216
109EEG with generalized epileptiform discharges (HP:0011198)1.72935767
110Torticollis (HP:0000473)1.72568293
111Diminished motivation (HP:0000745)1.71733056
112Termporal pattern (HP:0011008)1.71292784
113Insidious onset (HP:0003587)1.71292784
114Urinary urgency (HP:0000012)1.70824706
115Failure to thrive in infancy (HP:0001531)1.69173926
116Medial flaring of the eyebrow (HP:0010747)1.68741673
117Generalized hypopigmentation of hair (HP:0011358)1.68525155
118Deeply set eye (HP:0000490)1.68513745
119Incomplete penetrance (HP:0003829)1.67698324
120Abnormality of the ischium (HP:0003174)1.66841239
121Impaired vibratory sensation (HP:0002495)1.64672751
122Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.64567370
123Hemiplegia (HP:0002301)1.64526987
124Lower limb asymmetry (HP:0100559)1.64513154
125Ulnar claw (HP:0001178)1.64360451
126Hypoplasia of the corpus callosum (HP:0002079)1.63885495
127Peripheral hypomyelination (HP:0007182)1.63160236
128Heterochromia iridis (HP:0001100)1.63054655
129Abnormal social behavior (HP:0012433)1.62758724
130Impaired social interactions (HP:0000735)1.62758724
131Abnormality of calcium-phosphate metabolism (HP:0100530)1.62475617
132Pheochromocytoma (HP:0002666)1.62463532
133Abnormality of ocular smooth pursuit (HP:0000617)1.62115393
134Bowel diverticulosis (HP:0005222)1.61827677
135Bronchomalacia (HP:0002780)1.61750366
136Focal dystonia (HP:0004373)1.61374355
137Congenital primary aphakia (HP:0007707)1.60978685
138Round face (HP:0000311)1.60659378
139Amyotrophic lateral sclerosis (HP:0007354)1.59653718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.72402813
2CASK3.63157013
3EPHA43.29268789
4MAP2K72.83947279
5MAP3K42.81385954
6MAP3K92.71965591
7MARK12.49494590
8MINK12.42540527
9TNIK2.30564914
10MAP3K122.21302963
11DAPK22.15562028
12RIPK42.11867685
13PLK21.99021824
14PRPF4B1.91563600
15MAPK131.88736033
16NTRK21.82937904
17PAK61.78834418
18NTRK11.76138864
19MAP2K41.60960413
20FES1.58349968
21GRK51.52620060
22KSR11.45780800
23MAP3K131.42304614
24SIK21.40266239
25CDK51.38572910
26PRKD31.36689061
27PNCK1.31948506
28CAMKK11.30889144
29KSR21.25573545
30PDGFRA1.18732810
31PRKCG1.14649778
32CAMK2A1.13483239
33SIK31.11313497
34CAMKK21.10187403
35SGK21.09043383
36UHMK11.09016967
37STK381.07722156
38SGK4941.07482608
39SGK2231.07482608
40BMPR21.07452920
41DAPK11.06343263
42BMPR1B1.02290696
43CAMK1G1.02119181
44TAOK20.99264651
45CDK190.97875296
46MKNK20.95999522
47GRK70.92277235
48PTK2B0.89952858
49FGR0.89528355
50OXSR10.88967173
51CAMK2B0.88926661
52MAP3K20.86472066
53PRKCE0.84918868
54CAMK10.83774103
55ARAF0.81664145
56SGK10.81098169
57PRKCH0.76672324
58MOS0.75710288
59BCR0.75486716
60FGFR20.72871224
61STK110.71963233
62PAK30.71960223
63DYRK1A0.71941614
64SGK30.71406309
65TNK20.68327532
66TYRO30.66998067
67MUSK0.66858785
68CDK180.66400816
69NEK60.65742355
70WNK30.65738591
71RIPK10.65214913
72FER0.65091126
73CSNK1G20.64387695
74DYRK20.63781928
75LATS20.63695230
76INSRR0.62273667
77ADRBK20.61934095
78CDK140.61529998
79CAMK2D0.60911452
80CDK150.60557138
81RET0.58583682
82PKN10.57492439
83ALK0.56764308
84MAPKAPK50.55318565
85CAMK40.54616782
86STK38L0.54027442
87WNK10.53939100
88AKT30.53781910
89PHKG20.53503967
90PHKG10.53503967
91ERBB30.53139449
92DDR20.52931444
93MAP3K100.51460875
94PDGFRB0.50506557
95CCNB10.50260865
96CDC42BPA0.50063609
97MAPK120.50062606
98CDK11A0.48971513
99LMTK20.48785299
100ROCK10.47393099
101FYN0.47122708
102BRD40.46540639
103CDK30.45890168
104MARK20.45490395
105MAP3K10.43869360
106ADRBK10.43679887
107EPHB20.42122717
108CAMK2G0.41476906
109PDPK10.41271555
110ERBB20.41137639
111RAF10.41100446
112PDK10.41006176
113CSNK1A1L0.40486776
114MAPK100.40393745
115STK390.40305612
116PRKCZ0.40111250
117RPS6KA30.38569017
118ROCK20.38357744
119PINK10.37496520
120PRKG10.37131430
121NME10.36428245
122RPS6KA20.35825230
123CSNK1G10.35559226
124CAMK1D0.35522376
125DMPK0.35041796
126IRAK20.34876171

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.62168450
2Synaptic vesicle cycle_Homo sapiens_hsa047213.10636082
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51424295
4Olfactory transduction_Homo sapiens_hsa047402.44739533
5Circadian entrainment_Homo sapiens_hsa047132.40076290
6Glutamatergic synapse_Homo sapiens_hsa047242.38061420
7Morphine addiction_Homo sapiens_hsa050322.33197100
8GABAergic synapse_Homo sapiens_hsa047272.31034228
9Long-term potentiation_Homo sapiens_hsa047202.22415771
10Amphetamine addiction_Homo sapiens_hsa050312.20288392
11Salivary secretion_Homo sapiens_hsa049701.98902635
12Dopaminergic synapse_Homo sapiens_hsa047281.91226167
13Insulin secretion_Homo sapiens_hsa049111.90050966
14Collecting duct acid secretion_Homo sapiens_hsa049661.89852093
15Taste transduction_Homo sapiens_hsa047421.86283196
16Serotonergic synapse_Homo sapiens_hsa047261.85196289
17Cholinergic synapse_Homo sapiens_hsa047251.83748030
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69717051
19Gastric acid secretion_Homo sapiens_hsa049711.68502950
20Renin secretion_Homo sapiens_hsa049241.59068900
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58892529
22Long-term depression_Homo sapiens_hsa047301.58594289
23Calcium signaling pathway_Homo sapiens_hsa040201.54289936
24Cocaine addiction_Homo sapiens_hsa050301.50612911
25Oxytocin signaling pathway_Homo sapiens_hsa049211.49907164
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39510299
27GnRH signaling pathway_Homo sapiens_hsa049121.37115089
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37065505
29Axon guidance_Homo sapiens_hsa043601.35269693
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34095341
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31685743
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25706395
33Type II diabetes mellitus_Homo sapiens_hsa049301.23194012
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22385114
35cAMP signaling pathway_Homo sapiens_hsa040241.20790548
36Vibrio cholerae infection_Homo sapiens_hsa051101.20563040
37Phototransduction_Homo sapiens_hsa047441.19875770
38Gap junction_Homo sapiens_hsa045401.15221849
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13276810
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11841879
41Glioma_Homo sapiens_hsa052141.09645243
42ErbB signaling pathway_Homo sapiens_hsa040121.05725597
43Melanogenesis_Homo sapiens_hsa049161.04507090
44Hippo signaling pathway_Homo sapiens_hsa043901.00914546
45Estrogen signaling pathway_Homo sapiens_hsa049151.00544253
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96268420
47Hedgehog signaling pathway_Homo sapiens_hsa043400.92983813
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.91243437
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91183538
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.89855013
51Dorso-ventral axis formation_Homo sapiens_hsa043200.88660445
52ECM-receptor interaction_Homo sapiens_hsa045120.84183620
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83577273
54Bile secretion_Homo sapiens_hsa049760.79780629
55Choline metabolism in cancer_Homo sapiens_hsa052310.79555327
56Vitamin B6 metabolism_Homo sapiens_hsa007500.78599119
57Focal adhesion_Homo sapiens_hsa045100.78507829
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78327614
59Pancreatic secretion_Homo sapiens_hsa049720.77451594
60Rheumatoid arthritis_Homo sapiens_hsa053230.76937342
61Colorectal cancer_Homo sapiens_hsa052100.75701496
62Dilated cardiomyopathy_Homo sapiens_hsa054140.74907885
63Ras signaling pathway_Homo sapiens_hsa040140.74881320
64MAPK signaling pathway_Homo sapiens_hsa040100.74491833
65Cardiac muscle contraction_Homo sapiens_hsa042600.74435442
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70344324
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.65865351
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65529399
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64527038
70Adherens junction_Homo sapiens_hsa045200.64310573
71Type I diabetes mellitus_Homo sapiens_hsa049400.64073285
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63826194
73Basal cell carcinoma_Homo sapiens_hsa052170.63724609
74Inositol phosphate metabolism_Homo sapiens_hsa005620.62609109
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.62455634
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62205220
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62094688
78Thyroid hormone synthesis_Homo sapiens_hsa049180.62066338
79Rap1 signaling pathway_Homo sapiens_hsa040150.61041117
80Phagosome_Homo sapiens_hsa041450.60999174
81African trypanosomiasis_Homo sapiens_hsa051430.60731897
82Proteoglycans in cancer_Homo sapiens_hsa052050.60596625
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60563135
84mTOR signaling pathway_Homo sapiens_hsa041500.60383392
85MicroRNAs in cancer_Homo sapiens_hsa052060.59127441
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58381818
87Wnt signaling pathway_Homo sapiens_hsa043100.57362305
88Insulin signaling pathway_Homo sapiens_hsa049100.55864654
89Oocyte meiosis_Homo sapiens_hsa041140.55555447
90Fatty acid biosynthesis_Homo sapiens_hsa000610.55222292
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53035846
92AMPK signaling pathway_Homo sapiens_hsa041520.52963802
93Chemokine signaling pathway_Homo sapiens_hsa040620.52308804
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51792730
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50005324
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48897978
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48779227
98Ovarian steroidogenesis_Homo sapiens_hsa049130.47720997
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47518625
100Melanoma_Homo sapiens_hsa052180.47468673
101Protein digestion and absorption_Homo sapiens_hsa049740.47343599
102Tight junction_Homo sapiens_hsa045300.46737002
103TGF-beta signaling pathway_Homo sapiens_hsa043500.46473300
104VEGF signaling pathway_Homo sapiens_hsa043700.46229093
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45970671
106Amoebiasis_Homo sapiens_hsa051460.45669261
107Endocytosis_Homo sapiens_hsa041440.45256641
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44654666
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43352164
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42616019
111Alcoholism_Homo sapiens_hsa050340.42092476
112Circadian rhythm_Homo sapiens_hsa047100.41518033
113Alzheimers disease_Homo sapiens_hsa050100.41229963
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41014135
115Prion diseases_Homo sapiens_hsa050200.40583833
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40277155
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39471172
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38413956
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38209625
120Endometrial cancer_Homo sapiens_hsa052130.38128996
121Renal cell carcinoma_Homo sapiens_hsa052110.37444205
122Sphingolipid metabolism_Homo sapiens_hsa006000.37279031
123Glucagon signaling pathway_Homo sapiens_hsa049220.36552436
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36018911
125Prolactin signaling pathway_Homo sapiens_hsa049170.33600295

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