CDK18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.32086740
2central nervous system myelination (GO:0022010)6.32086740
3synaptic vesicle docking involved in exocytosis (GO:0016081)6.10190983
4sodium ion export (GO:0071436)5.68425383
5cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.49217892
6synaptic vesicle maturation (GO:0016188)5.47622266
7cellular potassium ion homeostasis (GO:0030007)5.27925980
8glutamate secretion (GO:0014047)5.21091187
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.15438103
10L-phenylalanine catabolic process (GO:0006559)5.15438103
11fatty acid elongation (GO:0030497)5.07974563
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.85447734
13synaptic vesicle exocytosis (GO:0016079)4.83047258
14cell communication by electrical coupling (GO:0010644)4.79607931
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.74609360
16L-phenylalanine metabolic process (GO:0006558)4.74609360
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.38755833
18regulation of synaptic vesicle exocytosis (GO:2000300)4.38358903
19amyloid precursor protein metabolic process (GO:0042982)4.34542278
20cell communication involved in cardiac conduction (GO:0086065)4.31940312
21neuronal ion channel clustering (GO:0045161)4.29858396
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.28488723
23intestinal cholesterol absorption (GO:0030299)4.19604662
24positive regulation of synapse maturation (GO:0090129)4.19245373
25response to methylmercury (GO:0051597)4.01751665
26neurotransmitter secretion (GO:0007269)3.92346960
27potassium ion homeostasis (GO:0055075)3.90635579
28cellular sodium ion homeostasis (GO:0006883)3.84712690
29regulation of neuronal synaptic plasticity (GO:0048168)3.83636660
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.78190902
31regulation of lipoprotein metabolic process (GO:0050746)3.77778953
32potassium ion import (GO:0010107)3.76568934
33locomotory exploration behavior (GO:0035641)3.73128121
34aromatic amino acid family catabolic process (GO:0009074)3.72140736
35cerebellar granule cell differentiation (GO:0021707)3.68290499
36regulation of synaptic vesicle transport (GO:1902803)3.66073642
37triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.65774067
38ensheathment of neurons (GO:0007272)3.65629152
39axon ensheathment (GO:0008366)3.65629152
40cholesterol biosynthetic process (GO:0006695)3.64556927
41myelination (GO:0042552)3.60365298
42amyloid precursor protein catabolic process (GO:0042987)3.57399107
43cytoskeletal anchoring at plasma membrane (GO:0007016)3.54388927
44L-amino acid import (GO:0043092)3.53846395
45cofactor catabolic process (GO:0051187)3.49019234
46coenzyme catabolic process (GO:0009109)3.48544705
47very long-chain fatty acid metabolic process (GO:0000038)3.48098629
48regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.46274559
49neuromuscular process controlling balance (GO:0050885)3.45990236
50regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.44897360
51creatine metabolic process (GO:0006600)3.43093136
52myelin maintenance (GO:0043217)3.42668467
53vocalization behavior (GO:0071625)3.42239047
54heme transport (GO:0015886)3.42047004
55plasma lipoprotein particle clearance (GO:0034381)3.41469697
56adhesion of symbiont to host cell (GO:0044650)3.40697261
57virion attachment to host cell (GO:0019062)3.40697261
58regulation of synapse maturation (GO:0090128)3.35928200
59cholesterol efflux (GO:0033344)3.35848290
60postsynaptic membrane organization (GO:0001941)3.34273395
61positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.33999140
62alpha-linolenic acid metabolic process (GO:0036109)3.32562818
63sterol biosynthetic process (GO:0016126)3.30256422
64regulation of long-term neuronal synaptic plasticity (GO:0048169)3.28889333
65very-low-density lipoprotein particle assembly (GO:0034379)3.25754023
66regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.24309363
67neurotransmitter transport (GO:0006836)3.23250773
68regulation of voltage-gated calcium channel activity (GO:1901385)3.22332198
69response to lipoprotein particle (GO:0055094)3.21975631
70bile acid biosynthetic process (GO:0006699)3.21652094
71regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.21383084
72neurotransmitter-gated ion channel clustering (GO:0072578)3.17141250
73long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.16969322
74glyoxylate metabolic process (GO:0046487)3.16675670
75regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.16029006
76long-chain fatty acid biosynthetic process (GO:0042759)3.15571573
77cardiac muscle contraction (GO:0060048)3.13583685
78activation of protein kinase A activity (GO:0034199)3.12600699
79regulation of glutamate receptor signaling pathway (GO:1900449)3.12369871
80neuronal action potential propagation (GO:0019227)3.10978884
81regulation of cell communication by electrical coupling (GO:0010649)3.08520217
82cysteine metabolic process (GO:0006534)3.08497032
83fatty-acyl-CoA biosynthetic process (GO:0046949)3.08444780
84aldehyde catabolic process (GO:0046185)3.03812870
85regulation of triglyceride catabolic process (GO:0010896)3.03806036
86protein carboxylation (GO:0018214)3.03586386
87peptidyl-glutamic acid carboxylation (GO:0017187)3.03586386
88positive regulation of lipoprotein lipase activity (GO:0051006)3.03181380
89positive regulation of triglyceride lipase activity (GO:0061365)3.03181380
90regulation of synapse structural plasticity (GO:0051823)3.00873846
91peptidyl-tyrosine autophosphorylation (GO:0038083)3.00838847
92positive regulation of dendritic spine development (GO:0060999)2.99698785
93detection of calcium ion (GO:0005513)2.99499143
94regulation of ARF protein signal transduction (GO:0032012)2.97614430
95adhesion of symbiont to host (GO:0044406)2.96780290
96tyrosine metabolic process (GO:0006570)2.96095167
97regulation of collateral sprouting (GO:0048670)2.95995665
98regulation of neurotransmitter levels (GO:0001505)2.95736905
99fatty-acyl-CoA metabolic process (GO:0035337)2.94675343
100regulation of synaptic plasticity (GO:0048167)2.93660586
101intestinal absorption (GO:0050892)2.93606033
102cholesterol metabolic process (GO:0008203)2.93033118
103cholesterol homeostasis (GO:0042632)2.92695180
104bile acid metabolic process (GO:0008206)2.92457263
105sterol homeostasis (GO:0055092)2.91573821
106fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.90001727
107sulfur amino acid catabolic process (GO:0000098)2.89077856
108ionotropic glutamate receptor signaling pathway (GO:0035235)2.88612250
109regulation of cholesterol esterification (GO:0010872)2.88439556
110neurotransmitter uptake (GO:0001504)2.87896400
111long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.87721276
112glycosylceramide metabolic process (GO:0006677)2.87209610
113positive regulation of membrane potential (GO:0045838)2.85671572
114protein-lipid complex assembly (GO:0065005)2.85575419
115exploration behavior (GO:0035640)2.84975862
116negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84260096
117acidic amino acid transport (GO:0015800)2.81969948
118glutathione derivative metabolic process (GO:1901685)2.81777110
119glutathione derivative biosynthetic process (GO:1901687)2.81777110
120regulation of actin filament-based movement (GO:1903115)2.81214199
121regulation of cardiac muscle cell contraction (GO:0086004)2.80271010
122iron coordination entity transport (GO:1901678)2.79666865
123cardiac conduction (GO:0061337)2.76794130
124import into cell (GO:0098657)2.74350095
125high-density lipoprotein particle remodeling (GO:0034375)2.74072622
126positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.72526829
127sterol metabolic process (GO:0016125)2.71026730
128neutrophil activation involved in immune response (GO:0002283)2.70972009
129plasma lipoprotein particle assembly (GO:0034377)2.70625536
130layer formation in cerebral cortex (GO:0021819)2.70264683
131positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70239088
132phosphate ion transmembrane transport (GO:0035435)2.69619939
133synaptic vesicle endocytosis (GO:0048488)2.67269537
134gamma-aminobutyric acid transport (GO:0015812)2.64956452
135regulation of dendritic spine morphogenesis (GO:0061001)2.64757349
136isoprenoid biosynthetic process (GO:0008299)2.63850670
137aromatic amino acid family metabolic process (GO:0009072)2.63353148
138protein localization to endosome (GO:0036010)2.62892850
139positive regulation of sodium ion transport (GO:0010765)2.61735721
140negative regulation of dendrite morphogenesis (GO:0050774)2.61625854
141positive regulation of dendrite development (GO:1900006)2.61392250
142low-density lipoprotein particle clearance (GO:0034383)2.60220886
143glutamate metabolic process (GO:0006536)2.60007896
144sterol transport (GO:0015918)2.59728216
145cholesterol transport (GO:0030301)2.59728216
146acyl-CoA biosynthetic process (GO:0071616)2.57959340
147thioester biosynthetic process (GO:0035384)2.57959340
148amino acid import (GO:0043090)2.57832667
149lipoprotein transport (GO:0042953)2.57138121
150macroautophagy (GO:0016236)2.56775273
151regulation of excitatory postsynaptic membrane potential (GO:0060079)2.56766380
152leukocyte migration involved in inflammatory response (GO:0002523)2.54770814
153drug transmembrane transport (GO:0006855)2.54443966
154regulation of sodium ion transmembrane transport (GO:1902305)2.53995060
155positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.52118606
156peripheral nervous system axon ensheathment (GO:0032292)2.52118389
157myelination in peripheral nervous system (GO:0022011)2.52118389
158L-glutamate transport (GO:0015813)2.51835807
159regulation of neurotransmitter secretion (GO:0046928)2.51762341
160dicarboxylic acid biosynthetic process (GO:0043650)2.51633258
161negative regulation of cholesterol transport (GO:0032375)2.51309162
162negative regulation of sterol transport (GO:0032372)2.51309162
163neuromuscular process controlling posture (GO:0050884)2.51286979
164regulation of cholesterol metabolic process (GO:0090181)2.51273464
165astrocyte development (GO:0014002)2.50855903
166negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.49970757
167long-term memory (GO:0007616)2.49718099
168regulation of cholesterol biosynthetic process (GO:0045540)2.49707668
169response to mercury ion (GO:0046689)2.49369095
170cell volume homeostasis (GO:0006884)2.48557375
171regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.48298127
172regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.48023439
173flavonoid metabolic process (GO:0009812)2.46909693
174ethanol metabolic process (GO:0006067)2.46566388
175urea cycle (GO:0000050)2.46383363
176urea metabolic process (GO:0019627)2.46383363
177protein-lipid complex remodeling (GO:0034368)2.45967881
178macromolecular complex remodeling (GO:0034367)2.45967881
179plasma lipoprotein particle remodeling (GO:0034369)2.45967881
180kynurenine metabolic process (GO:0070189)2.45959809
181regulation of dendritic spine development (GO:0060998)2.45360315
182substantia nigra development (GO:0021762)2.44868349
183ethanol oxidation (GO:0006069)2.44680019
184reverse cholesterol transport (GO:0043691)2.44448662
185dicarboxylic acid transport (GO:0006835)2.42999004
186negative regulation of lipase activity (GO:0060192)2.42456670
187dendritic spine organization (GO:0097061)2.41659034
188cellular modified amino acid catabolic process (GO:0042219)2.40552999
189cellular response to catecholamine stimulus (GO:0071870)2.40132020
190cellular response to monoamine stimulus (GO:0071868)2.40132020
191regulation of heart rate by cardiac conduction (GO:0086091)2.39756961
192sodium ion homeostasis (GO:0055078)2.38994414

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.18164452
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.13846208
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.68367400
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.34135331
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.20762187
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.99196959
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.91705880
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.85780673
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.84763121
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.62231999
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.44659170
12EZH2_22144423_ChIP-Seq_EOC_Human2.38913661
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18703143
14ZFP281_18757296_ChIP-ChIP_E14_Mouse2.14601321
15KDM2B_26808549_Chip-Seq_K562_Human2.12025045
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11721269
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.10197645
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08986270
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06800946
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06325128
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06325128
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03270185
23* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01924635
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98290848
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.98146099
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.95092564
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.92319606
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.90663061
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90004678
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.85669548
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.84118620
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.83257872
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82644379
34* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80056387
35REST_21632747_ChIP-Seq_MESCs_Mouse1.78784850
36EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.77317770
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72890132
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.71332915
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.70848138
40CTCF_27219007_Chip-Seq_Bcells_Human1.66127684
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.65922377
42* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.64271061
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62958237
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62655697
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62546176
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61532857
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60876208
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60876208
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60168102
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59171314
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57317270
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.56197728
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.52544347
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.52007198
55SMC4_20622854_ChIP-Seq_HELA_Human1.50804067
56* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50554460
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.49310367
58* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49270608
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46958949
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45789864
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40653921
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.40161820
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37916508
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37871683
65SOX2_20726797_ChIP-Seq_SW620_Human1.36489362
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36020512
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35517074
68TET1_21490601_ChIP-Seq_MESCs_Mouse1.34812707
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34051236
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33368870
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31481885
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29805507
73* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29234929
74KDM2B_26808549_Chip-Seq_DND41_Human1.28986767
75* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28570103
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28240438
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.27267804
78P68_20966046_ChIP-Seq_HELA_Human1.26849486
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25071468
80GATA1_19941826_ChIP-Seq_K562_Human1.24827007
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.24548479
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.24163034
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24041040
84CREB1_26743006_Chip-Seq_LNCaP_Human1.22929405
85GATA4_25053715_ChIP-Seq_YYC3_Human1.22612432
86OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22459138
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20684564
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20510986
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16310337
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12505075
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11250894
92OCT4_19829295_ChIP-Seq_ESCs_Human1.10497064
93* TBX20_22080862_ChIP-Seq_HEART_Mouse1.09381824
94* TBX20_22328084_ChIP-Seq_HEART_Mouse1.09381824
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08450300
96CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08201169
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07527452
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07438005
99CLOCK_20551151_ChIP-Seq_293T_Human1.06426312
100CDX2_20551321_ChIP-Seq_CACO-2_Human1.06376566
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04761296
102SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04595143
103TRIM28_21343339_ChIP-Seq_HEK293_Human1.04104838
104EOMES_21245162_ChIP-Seq_HESCs_Human1.03708080
105ESR1_21235772_ChIP-Seq_MCF-7_Human1.03438482
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03424280
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02838639
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02479297
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02356529
110RING1B_27294783_Chip-Seq_NPCs_Mouse1.02200177
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01729375
112TET1_21451524_ChIP-Seq_MESCs_Mouse1.00907526
113TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.00507750
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00416707
115VDR_24787735_ChIP-Seq_THP-1_Human1.00410509
116AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00005712
117TP53_23651856_ChIP-Seq_MEFs_Mouse0.99086322
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98781600
119HNF4A_19822575_ChIP-Seq_HepG2_Human0.98612093
120ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96662640
121* TCF7_22412390_ChIP-Seq_EML_Mouse0.96472539
122DROSHA_22980978_ChIP-Seq_HELA_Human0.96454423
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96258324
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95671028
125* TP63_22573176_ChIP-Seq_HFKS_Human0.94490901
126* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94354423
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94130515
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93769835
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93455860
130GATA2_19941826_ChIP-Seq_K562_Human0.91843195
131TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90202477
132* SA1_27219007_Chip-Seq_ERYTHROID_Human0.89761259
133* GATA6_25053715_ChIP-Seq_YYC3_Human0.89755311
134CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88892892
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88867007
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88777404
137P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88615773
138ZNF263_19887448_ChIP-Seq_K562_Human0.88560705
139RUNX1_27514584_Chip-Seq_MCF-7_Human0.87819647
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87296529
141PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87224454
142* RACK7_27058665_Chip-Seq_MCF-7_Human0.86534417
143AHR_22903824_ChIP-Seq_MCF-7_Human0.86493709
144JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86293343
145SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86080004
146CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84552290
147RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82959178
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.82320462
149SPI1_23127762_ChIP-Seq_K562_Human0.82022384
150* LXR_22292898_ChIP-Seq_THP-1_Human0.80582073
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80457143
152ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80250422
153MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80039017
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.79499226
155NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78995934
156TP63_23658742_ChIP-Seq_EP156T_Human0.78572729
157CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77320017
158FOXA1_25552417_ChIP-Seq_VCAP_Human0.76541080
159WT1_25993318_ChIP-Seq_PODOCYTE_Human0.76161423
160MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.74529301
161HTT_18923047_ChIP-ChIP_STHdh_Human0.74176639
162* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.74077710
163EP300_21415370_ChIP-Seq_HL-1_Mouse0.73843239
164* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72744272
165MYC_19915707_ChIP-ChIP_AK7_Human0.72374672
166CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72066816
167EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.71925805
168PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71591598
169SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.70735207
170CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70726285
171MITF_21258399_ChIP-Seq_MELANOMA_Human0.70612839
172KLF5_25053715_ChIP-Seq_YYC3_Human0.70045018
173MTF2_20144788_ChIP-Seq_MESCs_Mouse0.70014387
174ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.68549917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.46116530
2MP0004859_abnormal_synaptic_plasticity5.32723612
3MP0005360_urolithiasis5.25318814
4MP0009840_abnormal_foam_cell4.02885596
5MP0005058_abnormal_lysosome_morphology4.02768738
6MP0003880_abnormal_central_pattern3.66146325
7MP0005423_abnormal_somatic_nervous3.51810482
8MP0005085_abnormal_gallbladder_physiolo3.51101682
9MP0000920_abnormal_myelination3.48723396
10MP0003690_abnormal_glial_cell3.42144660
11MP0008875_abnormal_xenobiotic_pharmacok3.40330717
12MP0003195_calcinosis3.24069299
13MP0005365_abnormal_bile_salt3.19232193
14MP0003635_abnormal_synaptic_transmissio3.14782635
15MP0001666_abnormal_nutrient_absorption3.03121438
16MP0003172_abnormal_lysosome_physiology2.96899455
17MP0005083_abnormal_biliary_tract2.80959717
18MP0003806_abnormal_nucleotide_metabolis2.76666686
19MP0008569_lethality_at_weaning2.71915357
20MP0002063_abnormal_learning/memory/cond2.52595562
21MP0002272_abnormal_nervous_system2.42925690
22MP0003879_abnormal_hair_cell2.40280737
23MP0009745_abnormal_behavioral_response2.39712560
24MP0000604_amyloidosis2.35661332
25MP0006082_CNS_inflammation2.24138005
26MP0009780_abnormal_chondrocyte_physiolo2.23286290
27MP0002734_abnormal_mechanical_nocicepti2.21191420
28MP0010329_abnormal_lipoprotein_level2.20280222
29MP0003252_abnormal_bile_duct2.19998392
30MP0003191_abnormal_cellular_cholesterol2.18342052
31MP0000751_myopathy2.12670964
32MP0000566_synostosis2.10238132
33MP0005332_abnormal_amino_acid2.01548272
34MP0005670_abnormal_white_adipose1.99691572
35MP0002572_abnormal_emotion/affect_behav1.98712280
36MP0003329_amyloid_beta_deposits1.95154482
37MP0002118_abnormal_lipid_homeostasis1.86040225
38MP0000579_abnormal_nail_morphology1.77408325
39MP0009046_muscle_twitch1.72128663
40MP0003950_abnormal_plasma_membrane1.65573298
41MP0001501_abnormal_sleep_pattern1.64994514
42MP0001968_abnormal_touch/_nociception1.64671335
43MP0003123_paternal_imprinting1.64238071
44MP0004084_abnormal_cardiac_muscle1.62201363
45MP0001502_abnormal_circadian_rhythm1.59242399
46MP0003183_abnormal_peptide_metabolism1.54316400
47MP0004215_abnormal_myocardial_fiber1.52790151
48MP0003868_abnormal_feces_composition1.51074261
49MP0003656_abnormal_erythrocyte_physiolo1.50840916
50MP0003634_abnormal_glial_cell1.50117628
51MP0004043_abnormal_pH_regulation1.48954217
52MP0002735_abnormal_chemical_nociception1.43962128
53MP0005451_abnormal_body_composition1.42763822
54MP0005584_abnormal_enzyme/coenzyme_acti1.41131115
55MP0004019_abnormal_vitamin_homeostasis1.41059745
56MP0001970_abnormal_pain_threshold1.39552906
57MP0002066_abnormal_motor_capabilities/c1.29538051
58MP0003137_abnormal_impulse_conducting1.28556929
59MP0004510_myositis1.28267529
60MP0005646_abnormal_pituitary_gland1.25890989
61MP0003705_abnormal_hypodermis_morpholog1.22330402
62MP0002733_abnormal_thermal_nociception1.20017215
63MP0009643_abnormal_urine_homeostasis1.19324490
64MP0004742_abnormal_vestibular_system1.19073887
65MP0000609_abnormal_liver_physiology1.18289494
66MP0003632_abnormal_nervous_system1.18233802
67MP0003122_maternal_imprinting1.18164484
68MP0004811_abnormal_neuron_physiology1.17302668
69MP0004036_abnormal_muscle_relaxation1.16140748
70MP0005257_abnormal_intraocular_pressure1.15101537
71MP0002067_abnormal_sensory_capabilities1.13217054
72MP0002089_abnormal_postnatal_growth/wei1.12557696
73MP0002882_abnormal_neuron_morphology1.11884198
74MP0000778_abnormal_nervous_system1.11636626
75MP0002557_abnormal_social/conspecific_i1.10873170
76MP0003300_gastrointestinal_ulcer1.10764464
77MP0002736_abnormal_nociception_after1.09492302
78MP0005167_abnormal_blood-brain_barrier1.09084111
79MP0005319_abnormal_enzyme/_coenzyme1.09040832
80MP0002419_abnormal_innate_immunity1.08643259
81MP0005464_abnormal_platelet_physiology1.06967649
82MP0001984_abnormal_olfaction1.06890412
83MP0000747_muscle_weakness1.06481052
84MP0000955_abnormal_spinal_cord1.05192567
85MP0000569_abnormal_digit_pigmentation1.04967981
86MP0003436_decreased_susceptibility_to1.04567299
87MP0001905_abnormal_dopamine_level1.04264812
88MP0001177_atelectasis1.03905672
89MP0005330_cardiomyopathy1.03713965
90MP0003633_abnormal_nervous_system1.02372366
91MP0002138_abnormal_hepatobiliary_system1.02214552
92MP0001348_abnormal_lacrimal_gland1.00750126
93MP0002229_neurodegeneration0.99955099
94MP0003075_altered_response_to0.97450431
95MP0006138_congestive_heart_failure0.97300589
96MP0002090_abnormal_vision0.96907978
97MP0000462_abnormal_digestive_system0.96199631
98MP0003878_abnormal_ear_physiology0.96065661
99MP0005377_hearing/vestibular/ear_phenot0.96065661
100MP0003631_nervous_system_phenotype0.95306974
101MP0004858_abnormal_nervous_system0.95236092
102MP0004130_abnormal_muscle_cell0.95069361
103MP0004142_abnormal_muscle_tone0.93470391
104MP0001963_abnormal_hearing_physiology0.92861368
105MP0009765_abnormal_xenobiotic_induced0.92739326
106MP0004087_abnormal_muscle_fiber0.91638799
107MP0001533_abnormal_skeleton_physiology0.91250746
108MP0003303_peritoneal_inflammation0.90802099
109MP0008469_abnormal_protein_level0.89461140
110MP0004924_abnormal_behavior0.88758089
111MP0005386_behavior/neurological_phenoty0.88758089
112MP0010630_abnormal_cardiac_muscle0.88742649
113MP0002972_abnormal_cardiac_muscle0.88080176
114MP0005408_hypopigmentation0.87957299
115MP0002249_abnormal_larynx_morphology0.87851772
116MP0000678_abnormal_parathyroid_gland0.85151425
117MP0000749_muscle_degeneration0.85002518
118MP0010678_abnormal_skin_adnexa0.84559293
119MP0002064_seizures0.84293029
120MP0001485_abnormal_pinna_reflex0.83985732
121MP0004484_altered_response_of0.82544471
122MP0003787_abnormal_imprinting0.81212614
123MP0002837_dystrophic_cardiac_calcinosis0.80264594
124MP0003186_abnormal_redox_activity0.79957494
125MP0009763_increased_sensitivity_to0.79800470
126MP0004085_abnormal_heartbeat0.79084137
127MP0004885_abnormal_endolymph0.79044092
128MP0002152_abnormal_brain_morphology0.78476920
129MP0005171_absent_coat_pigmentation0.77791672
130MP0005174_abnormal_tail_pigmentation0.77534849
131MP0009764_decreased_sensitivity_to0.76609240
132MP0001346_abnormal_lacrimal_gland0.75404828
133MP0002822_catalepsy0.74384915
134MP0002269_muscular_atrophy0.73911245
135MP0005165_increased_susceptibility_to0.72414908
136MP0005409_darkened_coat_color0.71504258
137MP0001529_abnormal_vocalization0.71262828
138MP0005666_abnormal_adipose_tissue0.70626187
139MP0002295_abnormal_pulmonary_circulatio0.69490361
140MP0001849_ear_inflammation0.68951669
141MP0003011_delayed_dark_adaptation0.68677267
142MP0005310_abnormal_salivary_gland0.68645660
143MP0001958_emphysema0.67833413
144MP0005166_decreased_susceptibility_to0.67383700
145MP0000598_abnormal_liver_morphology0.65912255
146MP0002909_abnormal_adrenal_gland0.65773311
147MP0002998_abnormal_bone_remodeling0.64839990
148MP0004381_abnormal_hair_follicle0.64136036
149MP0001765_abnormal_ion_homeostasis0.63776408
150MP0002184_abnormal_innervation0.62430384
151MP0004134_abnormal_chest_morphology0.62062295
152MP0001851_eye_inflammation0.61551373
153MP0003453_abnormal_keratinocyte_physiol0.60931492
154MP0008873_increased_physiological_sensi0.60868880
155MP0001764_abnormal_homeostasis0.59623609
156MP0001756_abnormal_urination0.59199613
157MP0008874_decreased_physiological_sensi0.59018000
158MP0005636_abnormal_mineral_homeostasis0.58894639
159MP0004270_analgesia0.58645359
160MP0009642_abnormal_blood_homeostasis0.58227763
161MP0005025_abnormal_response_to0.57915653
162MP0000003_abnormal_adipose_tissue0.56798021
163MP0002168_other_aberrant_phenotype0.55623479
164MP0002136_abnormal_kidney_physiology0.55578107
165MP0004947_skin_inflammation0.55443754
166MP0003638_abnormal_response/metabolism_0.54122730
167MP0008260_abnormal_autophagy0.53472359
168MP0005164_abnormal_response_to0.53343982
169MP0000383_abnormal_hair_follicle0.53209526
170MP0001486_abnormal_startle_reflex0.53203123
171MP0001440_abnormal_grooming_behavior0.52973983
172MP0005448_abnormal_energy_balance0.52078592
173MP0005535_abnormal_body_temperature0.51724645

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.46772001
2Axonal loss (HP:0003447)4.78488506
3Neurofibrillary tangles (HP:0002185)4.59812116
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.45516123
5Intrahepatic cholestasis (HP:0001406)4.40956531
6Ankle clonus (HP:0011448)4.33406968
7Increased cerebral lipofuscin (HP:0011813)4.24870638
8Bundle branch block (HP:0011710)4.23015814
9Xanthomatosis (HP:0000991)4.18686676
10Action tremor (HP:0002345)4.18002013
11Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.06721445
12Vacuolated lymphocytes (HP:0001922)3.96327135
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.82783052
14Degeneration of the lateral corticospinal tracts (HP:0002314)3.82783052
15Hyperlipoproteinemia (HP:0010980)3.79016381
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.77621590
17Sudden death (HP:0001699)3.76489936
18Focal motor seizures (HP:0011153)3.68059076
19Cerebral inclusion bodies (HP:0100314)3.62631999
20Diplopia (HP:0000651)3.55485224
21Abnormality of binocular vision (HP:0011514)3.55485224
22Obstructive sleep apnea (HP:0002870)3.52183656
23Focal seizures (HP:0007359)3.35032649
24Hyporeflexia of lower limbs (HP:0002600)3.32573023
25Deep venous thrombosis (HP:0002625)3.29661135
26Dysostosis multiplex (HP:0000943)3.22212677
27Supranuclear gaze palsy (HP:0000605)3.19872129
28Heart block (HP:0012722)3.18270123
29Hypercholesterolemia (HP:0003124)3.11029586
30Abnormal atrioventricular conduction (HP:0005150)3.02750323
31Abnormality of the corticospinal tract (HP:0002492)3.02137440
32Peripheral demyelination (HP:0011096)3.01764898
33Scanning speech (HP:0002168)2.99519425
34Epileptic encephalopathy (HP:0200134)2.96049609
35Dysmetria (HP:0001310)2.95118143
36Syncope (HP:0001279)2.92501170
37Right ventricular cardiomyopathy (HP:0011663)2.89012933
38Abnormality of monocarboxylic acid metabolism (HP:0010996)2.87519836
39Atrioventricular block (HP:0001678)2.87515811
40Amyloidosis (HP:0011034)2.86138587
41Fat malabsorption (HP:0002630)2.83307717
42Loss of speech (HP:0002371)2.82740066
43Ventricular fibrillation (HP:0001663)2.80054172
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.79728475
45Abnormality of macrophages (HP:0004311)2.77829764
46Onion bulb formation (HP:0003383)2.77279267
47Febrile seizures (HP:0002373)2.73357233
48Slow saccadic eye movements (HP:0000514)2.71978883
49Visual hallucinations (HP:0002367)2.67726744
50Ileus (HP:0002595)2.65022647
51Hepatosplenomegaly (HP:0001433)2.63965147
52Muscle fiber splitting (HP:0003555)2.60532328
53Intention tremor (HP:0002080)2.60095231
54Atonic seizures (HP:0010819)2.56031291
55Hypobetalipoproteinemia (HP:0003563)2.55736793
56Abnormality of liposaccharide metabolism (HP:0010968)2.54433524
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.54433524
58Abnormality of glycolipid metabolism (HP:0010969)2.54433524
59Joint hemorrhage (HP:0005261)2.54212777
60Parakeratosis (HP:0001036)2.53414319
61Postural instability (HP:0002172)2.52556767
62Atrial fibrillation (HP:0005110)2.52053144
63Alacrima (HP:0000522)2.52013566
64Turricephaly (HP:0000262)2.49890939
65Systemic lupus erythematosus (HP:0002725)2.49881682
66Ventricular arrhythmia (HP:0004308)2.49454492
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.48673536
68Annular pancreas (HP:0001734)2.46771397
69Epidermoid cyst (HP:0200040)2.46429697
70Abnormality of sulfur amino acid metabolism (HP:0004339)2.46277390
71Bronchomalacia (HP:0002780)2.45708442
72Urinary glycosaminoglycan excretion (HP:0003541)2.42540313
73Mucopolysacchariduria (HP:0008155)2.42540313
74Foot dorsiflexor weakness (HP:0009027)2.41508239
75Paraparesis (HP:0002385)2.41371957
76Steatorrhea (HP:0002570)2.40915275
77Insomnia (HP:0100785)2.40478536
78Prolonged partial thromboplastin time (HP:0003645)2.40269297
79Complement deficiency (HP:0004431)2.39767055
80Distal lower limb muscle weakness (HP:0009053)2.39572847
81Aplasia involving bones of the extremities (HP:0009825)2.39035566
82Aplasia involving bones of the upper limbs (HP:0009823)2.39035566
83Aplasia of the phalanges of the hand (HP:0009802)2.39035566
84Neuronal loss in central nervous system (HP:0002529)2.38499970
85Abnormal gallbladder physiology (HP:0012438)2.36880246
86Cholecystitis (HP:0001082)2.36880246
87Protuberant abdomen (HP:0001538)2.36208387
88Vascular calcification (HP:0004934)2.36072291
89Abnormality of the foot musculature (HP:0001436)2.35297888
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34912135
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34912135
92Abnormality of polysaccharide metabolism (HP:0011012)2.34912135
93Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.33754664
94Primary atrial arrhythmia (HP:0001692)2.33098724
95Torticollis (HP:0000473)2.31425774
96Upper limb amyotrophy (HP:0009129)2.31424007
97Distal upper limb amyotrophy (HP:0007149)2.31424007
98Abnormality of methionine metabolism (HP:0010901)2.31323864
99Ventricular tachycardia (HP:0004756)2.28617176
100Spastic tetraparesis (HP:0001285)2.28398739
101Myocardial infarction (HP:0001658)2.27978386
102Urinary bladder sphincter dysfunction (HP:0002839)2.27142729
103Increased circulating renin level (HP:0000848)2.25223392
104Clumsiness (HP:0002312)2.24501156
105Clonus (HP:0002169)2.24263345
106Supraventricular tachycardia (HP:0004755)2.24138586
107Generalized tonic-clonic seizures (HP:0002069)2.23843226
108Abnormality of the common coagulation pathway (HP:0010990)2.23730428
109Peripheral hypomyelination (HP:0007182)2.22198655
110Tetraplegia (HP:0002445)2.22088833
111Recurrent gram-negative bacterial infections (HP:0005420)2.21232707
112Abnormality of the salivary glands (HP:0010286)2.20274177
113Depression (HP:0000716)2.19098781
114Abnormal eating behavior (HP:0100738)2.18997339
115Conjugated hyperbilirubinemia (HP:0002908)2.18821373
116Abnormality of the Achilles tendon (HP:0005109)2.18636103
117Abnormal gallbladder morphology (HP:0012437)2.17857135
118Supraventricular arrhythmia (HP:0005115)2.16763001
119Elevated alkaline phosphatase (HP:0003155)2.16352007
120Ketosis (HP:0001946)2.16206800
121Rapidly progressive (HP:0003678)2.15350569
122Abnormality of glycine metabolism (HP:0010895)2.15283726
123Abnormality of serine family amino acid metabolism (HP:0010894)2.15283726
124Lower limb amyotrophy (HP:0007210)2.15019639
125Abnormal enzyme/coenzyme activity (HP:0012379)2.14632980
126Truncal ataxia (HP:0002078)2.13092633
127Cerebral aneurysm (HP:0004944)2.11864484
128Lower limb muscle weakness (HP:0007340)2.11784359
129Hypophosphatemic rickets (HP:0004912)2.09650041
130Cerebral hemorrhage (HP:0001342)2.07926962
131Increased serum ferritin (HP:0003281)2.07557505
132Rigidity (HP:0002063)2.07251845
133Hydroxyprolinuria (HP:0003080)2.03583467
134Abnormality of proline metabolism (HP:0010907)2.03583467
135Abnormality of alkaline phosphatase activity (HP:0004379)2.03518548
136Recurrent bacterial skin infections (HP:0005406)2.03154870
137Skin nodule (HP:0200036)2.02953411
138Hyperammonemia (HP:0001987)2.02777766
139Abnormality of vision evoked potentials (HP:0000649)2.02301467
140Urinary urgency (HP:0000012)2.02145102
141Abnormal auditory evoked potentials (HP:0006958)2.01496499
142Cardiovascular calcification (HP:0011915)2.00118176
143Abnormality of the periventricular white matter (HP:0002518)1.99468671
144Abnormality of the intrinsic pathway (HP:0010989)1.99252091
145Spastic paraparesis (HP:0002313)1.98717451
146Segmental peripheral demyelination/remyelination (HP:0003481)1.98102558
147Cholelithiasis (HP:0001081)1.97909302
148Morphological abnormality of the inner ear (HP:0011390)1.97810431
149Pathologic fracture (HP:0002756)1.96110858
150Achilles tendon contracture (HP:0001771)1.95446349
151EMG: neuropathic changes (HP:0003445)1.93211813
152Hypolipoproteinemia (HP:0010981)1.91817730
153Sudden cardiac death (HP:0001645)1.91812725
154Dysdiadochokinesis (HP:0002075)1.91726829
155Status epilepticus (HP:0002133)1.90958570
156Dysmetric saccades (HP:0000641)1.90843348
157Cerebral hypomyelination (HP:0006808)1.90341854
158Sleep apnea (HP:0010535)1.90325280
159Sensory axonal neuropathy (HP:0003390)1.89913043
160Abnormality of the lower motor neuron (HP:0002366)1.88738180
161Anxiety (HP:0000739)1.88700686
162Termporal pattern (HP:0011008)1.87625781
163Insidious onset (HP:0003587)1.87625781
164Akinesia (HP:0002304)1.86841662
165Global brain atrophy (HP:0002283)1.86172477
166Spastic gait (HP:0002064)1.86141924
167Hemiplegia (HP:0002301)1.85948907
168Increased serum pyruvate (HP:0003542)1.84953294
169Abnormality of glycolysis (HP:0004366)1.84953294
170Distal sensory impairment (HP:0002936)1.84483906
171Progressive cerebellar ataxia (HP:0002073)1.84371446
172Stridor (HP:0010307)1.84160926
173Prolonged QT interval (HP:0001657)1.83635946
174Partial duplication of thumb phalanx (HP:0009944)1.82212284
175Hyperacusis (HP:0010780)1.81026091
176Mutism (HP:0002300)1.80064818
177Choreoathetosis (HP:0001266)1.79373676
178Shallow orbits (HP:0000586)1.79362126
179Hand muscle atrophy (HP:0009130)1.78895790
180Apathy (HP:0000741)1.77959674
181Abnormal EKG (HP:0003115)1.76409624
182Hammertoe (HP:0001765)1.76333377
183Centrally nucleated skeletal muscle fibers (HP:0003687)1.75832602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.68754385
2EPHB14.40495990
3EPHA43.76206128
4RIPK13.29545859
5NTRK33.27894016
6OXSR13.16816434
7MAPKAPK53.10061085
8PBK2.68503957
9PRKD32.66113192
10MARK12.62799737
11ERN12.54882651
12DAPK22.52561922
13BCKDK2.43314086
14WNK42.24211788
15NTRK22.22584404
16TAOK32.22147025
17PKN12.14635443
18MET2.05996448
19TRIB32.05143441
20PRPF4B1.80361890
21MAP3K91.73527986
22CAMKK11.70767844
23NTRK11.69991336
24FGFR41.58858166
25FGR1.55117736
26BMX1.54460094
27PTK61.46802071
28WNK11.44799081
29MINK11.42882170
30LATS21.37750759
31LMTK21.35754473
32KIT1.34489221
33TESK21.29851064
34GSK3A1.29600368
35TBK11.27367002
36SIK11.26173886
37NEK61.25072966
38MAP2K21.21977662
39ARAF1.21054314
40CAMK11.19470825
41DMPK1.14773167
42MST41.13850030
43ABL21.12120194
44PDPK11.12047492
45MAP3K21.11712222
46PHKG21.08979321
47PHKG11.08979321
48PTK21.08753774
49TTN1.08123758
50CAMK2D1.07453828
51IRAK41.06230281
52CSNK1G31.05961835
53SGK2231.05945783
54SGK4941.05945783
55FES1.04988556
56MST1R1.03609225
57CSF1R1.01416130
58PRKG21.01350489
59UHMK11.01335134
60GRK51.00326605
61PDGFRA1.00141509
62ICK0.98989622
63SMG10.98182213
64EEF2K0.97224297
65MOS0.95893012
66PRKD10.94653774
67STK380.94589542
68DAPK10.92891686
69EPHA20.92094929
70SGK30.91359778
71SIK20.91265376
72MAP3K110.89372098
73ERBB40.88984098
74MAP3K130.88404303
75ROCK20.87688069
76IRAK30.87645492
77BLK0.86736989
78MAPK100.86354179
79MYLK0.84635756
80IRAK20.83949212
81CSNK1A1L0.83373927
82CSNK1G20.82633641
83CSK0.82499283
84CAMK2B0.82016398
85TYRO30.81134513
86PRKCQ0.79865350
87CDK150.78773989
88PIK3CG0.78623506
89CSNK1G10.77989698
90SGK20.77725824
91CAMK1G0.76590176
92FGFR30.74391687
93CDK180.72364950
94MAP3K70.72317572
95CDK11A0.72191349
96CAMK2G0.71632994
97MUSK0.70457583
98SGK10.69546463
99RIPK40.68901204
100FYN0.65952955
101CAMK40.65844166
102STK110.65630454
103RET0.65525407
104GRK70.65420755
105PAK60.65261609
106CDC42BPA0.64738061
107MAP3K10.64298512
108HCK0.64097102
109DDR20.62908056
110PLK20.62864542
111ROCK10.62831199
112CAMK1D0.62012612
113PAK30.61739858
114PDK10.60448625
115PAK20.59301020
116TESK10.58843776
117EGFR0.58560971
118RPS6KA30.58109348
119CDK140.57066024
120PKN20.56828892
121DYRK1A0.56281512
122PRKCG0.54168347
123ABL10.52896840
124BCR0.51650016
125FGFR20.51521570
126TGFBR20.51450316
127PDGFRB0.51034487
128CAMK2A0.50288190
129KSR20.49594653
130DAPK30.49402949
131PIK3CA0.49365081
132MAP2K60.48674023
133TNK20.48349952
134TRPM70.47318587
135SRC0.46866969
136MTOR0.46089942
137LIMK10.45827078
138PRKCE0.45467295
139MARK20.44526615
140PRKCH0.42542325
141PRKG10.42472147
142CDK50.42266718
143ERBB20.42046107
144PRKCZ0.41893076
145MAPK120.41714597
146JAK20.40565700
147TYK20.40515735
148JAK10.40349627
149INSR0.40119913
150PRKACB0.39709597
151ALK0.38388856
152GRK60.37884691
153PINK10.37372124
154CSNK1A10.37248790

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.76712150
2Nitrogen metabolism_Homo sapiens_hsa009103.17582433
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.72741419
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.68643464
5Fatty acid elongation_Homo sapiens_hsa000622.67040850
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.63028079
7Histidine metabolism_Homo sapiens_hsa003402.61642099
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.44914144
9Nicotine addiction_Homo sapiens_hsa050332.21104581
10Long-term potentiation_Homo sapiens_hsa047202.19700199
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16599674
12Insulin secretion_Homo sapiens_hsa049112.03822276
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.00951286
14Sulfur metabolism_Homo sapiens_hsa009201.97345074
15GABAergic synapse_Homo sapiens_hsa047271.94784562
16Circadian entrainment_Homo sapiens_hsa047131.94613037
17Arginine biosynthesis_Homo sapiens_hsa002201.90924473
18Glutamatergic synapse_Homo sapiens_hsa047241.88935739
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87343721
20Gastric acid secretion_Homo sapiens_hsa049711.86905595
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86418484
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.81103199
23Amphetamine addiction_Homo sapiens_hsa050311.80884772
24Morphine addiction_Homo sapiens_hsa050321.77987097
25Lysosome_Homo sapiens_hsa041421.73358480
26Butanoate metabolism_Homo sapiens_hsa006501.72775215
27Fat digestion and absorption_Homo sapiens_hsa049751.71058433
28Vitamin B6 metabolism_Homo sapiens_hsa007501.70827465
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68571620
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65794628
31Tryptophan metabolism_Homo sapiens_hsa003801.61157674
32Caffeine metabolism_Homo sapiens_hsa002321.58274427
33Complement and coagulation cascades_Homo sapiens_hsa046101.57927289
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57141422
35Ether lipid metabolism_Homo sapiens_hsa005651.54739692
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53779843
37Peroxisome_Homo sapiens_hsa041461.49406167
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48610074
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46615719
40Staphylococcus aureus infection_Homo sapiens_hsa051501.46509779
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.43818654
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43459620
43Renin secretion_Homo sapiens_hsa049241.41488930
44Dilated cardiomyopathy_Homo sapiens_hsa054141.40689611
45Bile secretion_Homo sapiens_hsa049761.39819241
46Fatty acid degradation_Homo sapiens_hsa000711.39731520
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.38719183
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37764345
49Chemical carcinogenesis_Homo sapiens_hsa052041.37601719
50PPAR signaling pathway_Homo sapiens_hsa033201.35806991
51Dopaminergic synapse_Homo sapiens_hsa047281.35780479
52Vitamin digestion and absorption_Homo sapiens_hsa049771.35056449
53Fatty acid metabolism_Homo sapiens_hsa012121.33922653
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33671814
55Cocaine addiction_Homo sapiens_hsa050301.32273575
56Salivary secretion_Homo sapiens_hsa049701.31275370
57Folate biosynthesis_Homo sapiens_hsa007901.25960999
58Arginine and proline metabolism_Homo sapiens_hsa003301.25873574
59beta-Alanine metabolism_Homo sapiens_hsa004101.24403129
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.20957478
61Collecting duct acid secretion_Homo sapiens_hsa049661.18640314
62Cholinergic synapse_Homo sapiens_hsa047251.18287576
63Propanoate metabolism_Homo sapiens_hsa006401.17377713
64cAMP signaling pathway_Homo sapiens_hsa040241.16396807
65ABC transporters_Homo sapiens_hsa020101.14367257
66GnRH signaling pathway_Homo sapiens_hsa049121.13644834
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13353087
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11283997
69Thyroid hormone synthesis_Homo sapiens_hsa049181.10993790
70Oxytocin signaling pathway_Homo sapiens_hsa049211.10195786
71Estrogen signaling pathway_Homo sapiens_hsa049151.08845675
72Starch and sucrose metabolism_Homo sapiens_hsa005001.08720491
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06475425
74Calcium signaling pathway_Homo sapiens_hsa040201.06424302
75Glycosaminoglycan degradation_Homo sapiens_hsa005311.05751632
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01494916
77Mineral absorption_Homo sapiens_hsa049781.01188235
78Phospholipase D signaling pathway_Homo sapiens_hsa040721.00915099
79Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00643159
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97674204
81Linoleic acid metabolism_Homo sapiens_hsa005910.97398083
82Retinol metabolism_Homo sapiens_hsa008300.97221280
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95828335
84Other glycan degradation_Homo sapiens_hsa005110.95230060
85Sphingolipid metabolism_Homo sapiens_hsa006000.94137997
86Glutathione metabolism_Homo sapiens_hsa004800.90657753
87Glioma_Homo sapiens_hsa052140.90323999
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90067389
89Cardiac muscle contraction_Homo sapiens_hsa042600.89291308
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87849808
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86633799
92Melanogenesis_Homo sapiens_hsa049160.86058582
93Gap junction_Homo sapiens_hsa045400.85176269
94Taste transduction_Homo sapiens_hsa047420.84138068
95Glycerolipid metabolism_Homo sapiens_hsa005610.80586273
96Glucagon signaling pathway_Homo sapiens_hsa049220.79428971
97Tyrosine metabolism_Homo sapiens_hsa003500.79358970
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78048514
99Phenylalanine metabolism_Homo sapiens_hsa003600.77718596
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.76753746
101Inositol phosphate metabolism_Homo sapiens_hsa005620.75996424
102Phagosome_Homo sapiens_hsa041450.75653335
103Pyruvate metabolism_Homo sapiens_hsa006200.75499044
104ErbB signaling pathway_Homo sapiens_hsa040120.75269820
105VEGF signaling pathway_Homo sapiens_hsa043700.74264000
106Long-term depression_Homo sapiens_hsa047300.68710775
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68710284
108Serotonergic synapse_Homo sapiens_hsa047260.68352548
109Renin-angiotensin system_Homo sapiens_hsa046140.67065853
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66212412
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64480926
112Vibrio cholerae infection_Homo sapiens_hsa051100.63394274
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62111504
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62040413
115Rheumatoid arthritis_Homo sapiens_hsa053230.60793357
116Axon guidance_Homo sapiens_hsa043600.60670520
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.59939151
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.59889423
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59561783
120AMPK signaling pathway_Homo sapiens_hsa041520.59280786
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59224645
122Insulin signaling pathway_Homo sapiens_hsa049100.59101679
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.59043802
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57726233
125Tight junction_Homo sapiens_hsa045300.57650635
126Choline metabolism in cancer_Homo sapiens_hsa052310.56856375
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56396511
128Rap1 signaling pathway_Homo sapiens_hsa040150.56169961
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55176388
130Circadian rhythm_Homo sapiens_hsa047100.53191039
131Protein digestion and absorption_Homo sapiens_hsa049740.53061192
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.52228994
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51298075
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.50019989
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46112238
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45937209
137Prion diseases_Homo sapiens_hsa050200.44702024
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.43792115
139Ras signaling pathway_Homo sapiens_hsa040140.43728362
140Biosynthesis of amino acids_Homo sapiens_hsa012300.42786008
141ECM-receptor interaction_Homo sapiens_hsa045120.41950729
142Olfactory transduction_Homo sapiens_hsa047400.41610051
143Metabolic pathways_Homo sapiens_hsa011000.41073279
144Carbon metabolism_Homo sapiens_hsa012000.40684075
145MAPK signaling pathway_Homo sapiens_hsa040100.39642931
146mTOR signaling pathway_Homo sapiens_hsa041500.39605767
147Arachidonic acid metabolism_Homo sapiens_hsa005900.36677007
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.32623144
149Galactose metabolism_Homo sapiens_hsa000520.32077396
150Protein export_Homo sapiens_hsa030600.29639830
151Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29351667
152Pancreatic secretion_Homo sapiens_hsa049720.28010060
153Lysine degradation_Homo sapiens_hsa003100.26401107
154Selenocompound metabolism_Homo sapiens_hsa004500.26213601
155Fructose and mannose metabolism_Homo sapiens_hsa000510.25920635
156Synaptic vesicle cycle_Homo sapiens_hsa047210.25025605
157Hepatitis C_Homo sapiens_hsa051600.23798999
158Type II diabetes mellitus_Homo sapiens_hsa049300.22868004
159Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22735538
160Endocytosis_Homo sapiens_hsa041440.20938715
161Oxidative phosphorylation_Homo sapiens_hsa001900.19894642
162Malaria_Homo sapiens_hsa051440.19783953
163Ovarian steroidogenesis_Homo sapiens_hsa049130.19616784
164Fatty acid biosynthesis_Homo sapiens_hsa000610.19187174
165Toll-like receptor signaling pathway_Homo sapiens_hsa046200.19084900
166Amoebiasis_Homo sapiens_hsa051460.18694630
167Renal cell carcinoma_Homo sapiens_hsa052110.18289321

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »