CDK19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)4.86143620
2axon ensheathment in central nervous system (GO:0032291)4.86143620
3synaptic vesicle maturation (GO:0016188)4.06006077
4locomotory exploration behavior (GO:0035641)4.00284824
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.62502048
6nerve growth factor signaling pathway (GO:0038180)3.55418143
7myelination (GO:0042552)3.48494504
8axon ensheathment (GO:0008366)3.48021672
9ensheathment of neurons (GO:0007272)3.48021672
10cerebellar granule cell differentiation (GO:0021707)3.46007462
11L-amino acid import (GO:0043092)3.43780054
12import into cell (GO:0098657)3.39022632
13establishment of nucleus localization (GO:0040023)3.16835545
14regulation of ARF GTPase activity (GO:0032312)3.13100650
15regulation of ARF protein signal transduction (GO:0032012)3.13095821
16positive regulation of CREB transcription factor activity (GO:0032793)3.09905677
17axonal fasciculation (GO:0007413)3.09537574
18cerebellar Purkinje cell differentiation (GO:0021702)3.06361041
19phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.01516176
20myelin maintenance (GO:0043217)2.94988609
21Golgi to endosome transport (GO:0006895)2.90382558
22presynaptic membrane organization (GO:0097090)2.87993399
23regulation of short-term neuronal synaptic plasticity (GO:0048172)2.86980575
24cell differentiation in hindbrain (GO:0021533)2.85002135
25regulation of voltage-gated calcium channel activity (GO:1901385)2.82896687
26positive regulation of Rap GTPase activity (GO:0032854)2.82811951
27mast cell degranulation (GO:0043303)2.82040186
28mast cell activation involved in immune response (GO:0002279)2.82040186
29mast cell activation (GO:0045576)2.82020378
30embryonic retina morphogenesis in camera-type eye (GO:0060059)2.81479699
31detection of molecule of bacterial origin (GO:0032490)2.80336725
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.78292404
33cortical actin cytoskeleton organization (GO:0030866)2.77951611
34neuronal action potential propagation (GO:0019227)2.76245635
35negative regulation of neurotransmitter secretion (GO:0046929)2.75103932
36neuron recognition (GO:0008038)2.75102814
37ionotropic glutamate receptor signaling pathway (GO:0035235)2.74634003
38dendritic spine morphogenesis (GO:0060997)2.74208500
39iron ion import (GO:0097286)2.72378419
40cytoskeletal anchoring at plasma membrane (GO:0007016)2.71337063
41layer formation in cerebral cortex (GO:0021819)2.71227962
42pyrimidine nucleobase catabolic process (GO:0006208)2.71178224
43adult walking behavior (GO:0007628)2.71085879
44regulation of Rap GTPase activity (GO:0032317)2.70972801
45postsynaptic membrane organization (GO:0001941)2.70059729
46regulation of synaptic vesicle exocytosis (GO:2000300)2.69500063
47negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.68838449
48peptidyl-tyrosine autophosphorylation (GO:0038083)2.67716158
49activation of protein kinase A activity (GO:0034199)2.67461000
50regulation of macrophage cytokine production (GO:0010935)2.66045719
51presynaptic membrane assembly (GO:0097105)2.65408883
52positive regulation of gamma-delta T cell activation (GO:0046645)2.64590685
53regulation of clathrin-mediated endocytosis (GO:2000369)2.64488222
54regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.64218917
55negative regulation of dendrite morphogenesis (GO:0050774)2.63722812
56transmission of nerve impulse (GO:0019226)2.61564053
57positive regulation of macrophage cytokine production (GO:0060907)2.61219411
58sodium ion export (GO:0071436)2.59783592
59negative regulation of neurotransmitter transport (GO:0051589)2.59333435
60B cell receptor signaling pathway (GO:0050853)2.58588590
61clathrin coat assembly (GO:0048268)2.58200026
62cellular extravasation (GO:0045123)2.57758825
63peptidyl-threonine phosphorylation (GO:0018107)2.57205775
64dendrite morphogenesis (GO:0048813)2.56479541
65synaptic vesicle exocytosis (GO:0016079)2.56076035
66substrate-independent telencephalic tangential migration (GO:0021826)2.55133328
67substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.55133328
68neuromuscular process controlling balance (GO:0050885)2.54993720
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.54120661
70astrocyte development (GO:0014002)2.53703209
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.53702912
72potassium ion import (GO:0010107)2.53660591
73membrane tubulation (GO:0097320)2.53622216
74positive regulation by symbiont of host defense response (GO:0052509)2.53154559
75modulation by symbiont of host defense response (GO:0052031)2.53154559
76modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.53154559
77modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.53154559
78positive regulation by organism of defense response of other organism involved in symbiotic interact2.53154559
79modulation by symbiont of host immune response (GO:0052553)2.53154559
80neuronal ion channel clustering (GO:0045161)2.53004790
81negative regulation of inclusion body assembly (GO:0090084)2.52181562
82cellular potassium ion homeostasis (GO:0030007)2.51802924
83positive regulation of membrane potential (GO:0045838)2.51637291
84protein localization to endosome (GO:0036010)2.50824929
85glutamate secretion (GO:0014047)2.50259282
86positive regulation of dendritic spine morphogenesis (GO:0061003)2.50220553
87cortical cytoskeleton organization (GO:0030865)2.49704954
88positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.49497300
89negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.49014386
90histone H3-K4 trimethylation (GO:0080182)2.48879334
91phospholipid translocation (GO:0045332)2.48372999
92lipid translocation (GO:0034204)2.48372999
93cytoplasmic mRNA processing body assembly (GO:0033962)2.47815378
94histone H3-K9 demethylation (GO:0033169)2.47746022
95adenosine receptor signaling pathway (GO:0001973)2.43974428
96definitive hemopoiesis (GO:0060216)2.43364858
97regulation of somitogenesis (GO:0014807)2.43144798
98regulation of excitatory postsynaptic membrane potential (GO:0060079)2.42412529
99peptidyl-threonine modification (GO:0018210)2.42331514
100central nervous system projection neuron axonogenesis (GO:0021952)2.42001173
101synaptic vesicle docking involved in exocytosis (GO:0016081)2.41450172
102L-serine transport (GO:0015825)2.41445280
103microglial cell activation (GO:0001774)2.41348966
104long-term memory (GO:0007616)2.40480744
105angiogenesis involved in wound healing (GO:0060055)2.39476415
106regulation of synapse structural plasticity (GO:0051823)2.39432820
107regulation of dendritic spine morphogenesis (GO:0061001)2.38950957
108synaptic vesicle endocytosis (GO:0048488)2.38777488
109interkinetic nuclear migration (GO:0022027)2.38154448
110response to nerve growth factor (GO:1990089)2.38151327
111cellular response to nerve growth factor stimulus (GO:1990090)2.38151327
112insulin-like growth factor receptor signaling pathway (GO:0048009)2.36172938
113positive regulation of B cell differentiation (GO:0045579)2.35279060
114serine transport (GO:0032329)2.35075593
115cellular response to ethanol (GO:0071361)2.34759296
116megakaryocyte development (GO:0035855)2.34621446
117protein localization to synapse (GO:0035418)2.34595171
118photoreceptor cell differentiation (GO:0046530)2.34474892
119eye photoreceptor cell differentiation (GO:0001754)2.34474892
120mechanosensory behavior (GO:0007638)2.33847318
121regulation of long-term neuronal synaptic plasticity (GO:0048169)2.33204870
122histone lysine demethylation (GO:0070076)2.32959633
123prepulse inhibition (GO:0060134)2.31737003
124positive regulation of dendrite morphogenesis (GO:0050775)2.31491394
125cellular response to monoamine stimulus (GO:0071868)2.31421850
126cellular response to catecholamine stimulus (GO:0071870)2.31421850
127glutamate receptor signaling pathway (GO:0007215)2.30760280
128negative regulation of axonogenesis (GO:0050771)2.30744832
129auditory behavior (GO:0031223)2.30525016
130negative regulation of cell killing (GO:0031342)2.30026648
131negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.30026648
132leukocyte migration involved in inflammatory response (GO:0002523)2.29500013
133activated T cell proliferation (GO:0050798)2.27499161
134neuron cell-cell adhesion (GO:0007158)2.27194690
135regulation of dendrite morphogenesis (GO:0048814)2.25842392
136regulation of synaptic vesicle transport (GO:1902803)2.25559153
137long-term synaptic potentiation (GO:0060291)2.25541668
138asymmetric protein localization (GO:0008105)2.25176743
139vocalization behavior (GO:0071625)2.24162585
140regulation of dendritic spine development (GO:0060998)2.24097598
141amino acid import (GO:0043090)2.23842468
142positive regulation of dendritic spine development (GO:0060999)2.22790139
143regulation of neuronal synaptic plasticity (GO:0048168)2.22344802
144vesicle transport along microtubule (GO:0047496)2.22266657
145establishment of spindle orientation (GO:0051294)2.21964601
146synaptic transmission, glutamatergic (GO:0035249)2.21038773
147suckling behavior (GO:0001967)2.20242357
148macrophage activation involved in immune response (GO:0002281)2.20137931
149long-chain fatty acid biosynthetic process (GO:0042759)2.19621700
150G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.19605800
151cerebral cortex radially oriented cell migration (GO:0021799)2.19474576
152regulation of glutamate receptor signaling pathway (GO:1900449)2.19166654
153negative regulation of protein localization to cell surface (GO:2000009)2.18823308
154myeloid leukocyte mediated immunity (GO:0002444)2.18730864
155regulation of postsynaptic membrane potential (GO:0060078)2.18444401
156histone demethylation (GO:0016577)2.18350740
157exploration behavior (GO:0035640)2.18274093
158branching involved in prostate gland morphogenesis (GO:0060442)2.18053196
159regulation of NFAT protein import into nucleus (GO:0051532)2.17995380
160myelination in peripheral nervous system (GO:0022011)2.16174443
161peripheral nervous system axon ensheathment (GO:0032292)2.16174443
162positive regulation of mast cell activation (GO:0033005)2.15843378
163dendrite development (GO:0016358)2.12220022
164negative regulation of fatty acid transport (GO:2000192)2.12022813
165neurotransmitter-gated ion channel clustering (GO:0072578)2.11583493
166organelle transport along microtubule (GO:0072384)2.11373284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.71073951
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.89552095
3SCL_19346495_ChIP-Seq_HPC-7_Human2.47473976
4DROSHA_22980978_ChIP-Seq_HELA_Human2.43204035
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38949876
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.29180015
7RUNX_20019798_ChIP-Seq_JUKART_Human2.28180857
8AR_21572438_ChIP-Seq_LNCaP_Human2.18971405
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.17057791
10PIAS1_25552417_ChIP-Seq_VCAP_Human1.98873842
11GBX2_23144817_ChIP-Seq_PC3_Human1.89111160
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83329885
13EZH2_22144423_ChIP-Seq_EOC_Human1.81673249
14SMAD_19615063_ChIP-ChIP_OVARY_Human1.76087636
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74494922
16MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71121439
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70153822
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69490654
19* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65857461
20NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.60991996
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60038702
22* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59648000
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54443047
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54443047
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54251127
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53643180
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52998280
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49785259
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46371747
30KDM2B_26808549_Chip-Seq_DND41_Human1.46252986
31TCF7_22412390_ChIP-Seq_EML_Mouse1.45970423
32SPI1_23127762_ChIP-Seq_K562_Human1.45327464
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.44879840
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.43957395
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43626234
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.43543027
37SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43271721
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42784973
39* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42340442
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41341800
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.41042650
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40843401
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38470186
44* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36541017
45GATA1_22025678_ChIP-Seq_K562_Human1.36099518
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36018492
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35242811
48* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34637186
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34612180
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.34389557
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33926031
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33924143
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33669475
54TP53_16413492_ChIP-PET_HCT116_Human1.33038259
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30297480
56* VDR_24763502_ChIP-Seq_THP-1_Human1.29907083
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.28740119
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28274165
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28023152
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24077848
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24043206
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21100945
63AHR_22903824_ChIP-Seq_MCF-7_Human1.21008876
64TAF15_26573619_Chip-Seq_HEK293_Human1.20863307
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.19642819
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19626852
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19274775
68KDM2B_26808549_Chip-Seq_K562_Human1.18386620
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16318683
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15829988
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15588851
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14841204
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14285859
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14285859
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12851452
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12606473
77* VDR_21846776_ChIP-Seq_THP-1_Human1.12110341
78* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11948006
79* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10314068
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.09777963
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.09399460
82GATA1_19941826_ChIP-Seq_K562_Human1.09366020
83CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09228261
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.09002710
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.07652710
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06957686
87STAT3_23295773_ChIP-Seq_U87_Human1.06807393
88VDR_24787735_ChIP-Seq_THP-1_Human1.06784578
89REST_21632747_ChIP-Seq_MESCs_Mouse1.05799843
90FOXA2_19822575_ChIP-Seq_HepG2_Human1.05710283
91* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04105353
92* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03750730
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03104960
94EED_16625203_ChIP-ChIP_MESCs_Mouse1.02695582
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01954462
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01953901
97IGF1R_20145208_ChIP-Seq_DFB_Human1.01472918
98* MYB_26560356_Chip-Seq_TH2_Human1.00825050
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00816051
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00372580
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.00010417
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99786322
103NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99597889
104P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99170232
105* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98181556
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98179447
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97891139
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97342006
109AR_19668381_ChIP-Seq_PC3_Human0.97185955
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.97119910
111MAF_26560356_Chip-Seq_TH1_Human0.96204768
112CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95945958
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95797851
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95797851
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95558169
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95459781
117EZH2_27304074_Chip-Seq_ESCs_Mouse0.95104860
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94147229
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94049888
120GATA1_19941827_ChIP-Seq_MEL_Mouse0.94025364
121* GF1_26923725_Chip-Seq_HPCs_Mouse0.93966637
122* SMAD3_21741376_ChIP-Seq_EPCs_Human0.93963207
123TCF4_23295773_ChIP-Seq_U87_Human0.93821722
124ESR2_21235772_ChIP-Seq_MCF-7_Human0.93666836
125SMAD4_21799915_ChIP-Seq_A2780_Human0.93526178
126GATA3_27048872_Chip-Seq_THYMUS_Human0.92267529
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.92193645
128* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91599872
129SOX2_21211035_ChIP-Seq_LN229_Gbm0.90745130
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89223278
131* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89050231
132* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87808474
133YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87016782
134GATA2_19941826_ChIP-Seq_K562_Human0.86847380
135RXR_22108803_ChIP-Seq_LS180_Human0.86670634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.61258763
2MP0000920_abnormal_myelination3.43576176
3MP0005409_darkened_coat_color2.60164332
4MP0008569_lethality_at_weaning2.58867156
5MP0003635_abnormal_synaptic_transmissio2.57547447
6MP0004885_abnormal_endolymph2.55864842
7MP0003880_abnormal_central_pattern2.51446789
8MP0004270_analgesia2.40114908
9MP0003690_abnormal_glial_cell2.36654190
10MP0002064_seizures2.22356223
11MP0002735_abnormal_chemical_nociception2.19621167
12MP0009046_muscle_twitch2.14808154
13MP0001486_abnormal_startle_reflex2.11494646
14MP0009745_abnormal_behavioral_response2.07806946
15MP0002272_abnormal_nervous_system1.98541936
16MP0005423_abnormal_somatic_nervous1.89686484
17MP0004130_abnormal_muscle_cell1.87404346
18MP0002396_abnormal_hematopoietic_system1.85485632
19MP0003950_abnormal_plasma_membrane1.85211737
20MP0003183_abnormal_peptide_metabolism1.84251541
21MP0003705_abnormal_hypodermis_morpholog1.81612009
22MP0010678_abnormal_skin_adnexa1.81243983
23MP0002063_abnormal_learning/memory/cond1.80660027
24MP0004858_abnormal_nervous_system1.72283878
25MP0003300_gastrointestinal_ulcer1.67299231
26MP0000465_gastrointestinal_hemorrhage1.66881775
27MP0005671_abnormal_response_to1.64923075
28MP0000566_synostosis1.64634659
29MP0000569_abnormal_digit_pigmentation1.62018582
30MP0003122_maternal_imprinting1.59791723
31MP0005248_abnormal_Harderian_gland1.59676214
32MP0005551_abnormal_eye_electrophysiolog1.54939478
33MP0003303_peritoneal_inflammation1.50944135
34MP0003633_abnormal_nervous_system1.50252592
35MP0002572_abnormal_emotion/affect_behav1.49372969
36MP0003045_fibrosis1.48427627
37MP0000383_abnormal_hair_follicle1.45482317
38MP0005076_abnormal_cell_differentiation1.44210825
39MP0004742_abnormal_vestibular_system1.40368927
40MP0003634_abnormal_glial_cell1.39072583
41MP0003890_abnormal_embryonic-extraembry1.37583199
42MP0004147_increased_porphyrin_level1.37400929
43MP0000534_abnormal_ureter_morphology1.36729595
44MP0001873_stomach_inflammation1.35271675
45MP0001835_abnormal_antigen_presentation1.34698186
46MP0003724_increased_susceptibility_to1.34677554
47MP0002733_abnormal_thermal_nociception1.34397667
48MP0009780_abnormal_chondrocyte_physiolo1.29136056
49MP0005310_abnormal_salivary_gland1.28991037
50MP0002166_altered_tumor_susceptibility1.28421063
51MP0000778_abnormal_nervous_system1.27493245
52MP0003631_nervous_system_phenotype1.27143296
53MP0001851_eye_inflammation1.27001596
54MP0004811_abnormal_neuron_physiology1.24019288
55MP0003329_amyloid_beta_deposits1.19774846
56MP0002229_neurodegeneration1.19679991
57MP0002067_abnormal_sensory_capabilities1.19529896
58MP0000685_abnormal_immune_system1.19492168
59MP0004808_abnormal_hematopoietic_stem1.19457605
60MP0002734_abnormal_mechanical_nocicepti1.18861604
61MP0001800_abnormal_humoral_immune1.18167668
62MP0000015_abnormal_ear_pigmentation1.18130930
63MP0001968_abnormal_touch/_nociception1.16641359
64MP0003632_abnormal_nervous_system1.16456373
65MP0002420_abnormal_adaptive_immunity1.16444196
66MP0001485_abnormal_pinna_reflex1.16275142
67MP0004924_abnormal_behavior1.15740386
68MP0005386_behavior/neurological_phenoty1.15740386
69MP0003075_altered_response_to1.14464383
70MP0002882_abnormal_neuron_morphology1.14291332
71MP0001819_abnormal_immune_cell1.13169628
72MP0010234_abnormal_vibrissa_follicle1.11704336
73MP0004185_abnormal_adipocyte_glucose1.11143380
74MP0002822_catalepsy1.10292598
75MP0003121_genomic_imprinting1.10186453
76MP0002398_abnormal_bone_marrow1.10060144
77MP0005623_abnormal_meninges_morphology1.08787693
78MP0002452_abnormal_antigen_presenting1.07966696
79MP0005000_abnormal_immune_tolerance1.07542218
80MP0009278_abnormal_bone_marrow1.06876029
81MP0005167_abnormal_blood-brain_barrier1.06349513
82MP0002723_abnormal_immune_serum1.06139649
83MP0005174_abnormal_tail_pigmentation1.05677588
84MP0001790_abnormal_immune_system1.04276720
85MP0005387_immune_system_phenotype1.04276720
86MP0003091_abnormal_cell_migration1.04254426
87MP0005646_abnormal_pituitary_gland1.01935315
88MP0000716_abnormal_immune_system1.00437837
89MP0002184_abnormal_innervation0.99893276
90MP0005410_abnormal_fertilization0.98716487
91MP0000955_abnormal_spinal_cord0.96893216
92MP0003866_abnormal_defecation0.96152889
93MP0001502_abnormal_circadian_rhythm0.95196587
94MP0003861_abnormal_nervous_system0.94937134
95MP0001905_abnormal_dopamine_level0.94827367
96MP0008874_decreased_physiological_sensi0.94565558
97MP0003787_abnormal_imprinting0.92701977
98MP0002066_abnormal_motor_capabilities/c0.91874256
99MP0002736_abnormal_nociception_after0.91732944
100MP0005464_abnormal_platelet_physiology0.90441527
101MP0003828_pulmonary_edema0.90121160
102MP0005187_abnormal_penis_morphology0.88526777
103MP0003172_abnormal_lysosome_physiology0.85667871
104MP0001970_abnormal_pain_threshold0.84370094
105MP0002095_abnormal_skin_pigmentation0.84083989
106MP0000747_muscle_weakness0.84068383
107MP0003938_abnormal_ear_development0.83811443
108MP0004883_abnormal_blood_vessel0.83721680
109MP0002006_tumorigenesis0.83369785
110MP0004134_abnormal_chest_morphology0.82419060
111MP0002090_abnormal_vision0.82194059
112MP0000537_abnormal_urethra_morphology0.81756087
113MP0000703_abnormal_thymus_morphology0.81620638
114MP0002557_abnormal_social/conspecific_i0.81489397
115MP0002419_abnormal_innate_immunity0.81182270
116MP0001501_abnormal_sleep_pattern0.81034849
117MP0003942_abnormal_urinary_system0.80144245
118MP0004381_abnormal_hair_follicle0.79982186
119MP0001958_emphysema0.79980610
120MP0000371_diluted_coat_color0.79654981
121MP0005666_abnormal_adipose_tissue0.79070077
122MP0003763_abnormal_thymus_physiology0.78051450
123MP0005025_abnormal_response_to0.78026001
124MP0002152_abnormal_brain_morphology0.77289138
125MP0003115_abnormal_respiratory_system0.76787966
126MP0008961_abnormal_basal_metabolism0.76637267
127MP0003879_abnormal_hair_cell0.76422968
128MP0001177_atelectasis0.74532420
129MP0000604_amyloidosis0.74336789
130MP0005397_hematopoietic_system_phenotyp0.74242512
131MP0001545_abnormal_hematopoietic_system0.74242512
132MP0002249_abnormal_larynx_morphology0.73641263
133MP0001440_abnormal_grooming_behavior0.73331249
134MP0000689_abnormal_spleen_morphology0.73043342
135MP0003123_paternal_imprinting0.72870543
136MP0002009_preneoplasia0.72782163
137MP0002075_abnormal_coat/hair_pigmentati0.70714108
138MP0002971_abnormal_brown_adipose0.68945357
139MP0008260_abnormal_autophagy0.68350882
140MP0002909_abnormal_adrenal_gland0.64135565
141MP0005451_abnormal_body_composition0.61798329

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)4.43336797
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.43336797
3Chronic otitis media (HP:0000389)3.76938428
4Abnormality of the corticospinal tract (HP:0002492)3.63819024
5Intention tremor (HP:0002080)3.39584532
6Obstructive sleep apnea (HP:0002870)3.27426943
7Termporal pattern (HP:0011008)3.19948901
8Insidious onset (HP:0003587)3.19948901
9Supranuclear gaze palsy (HP:0000605)3.04778620
10Gaze-evoked nystagmus (HP:0000640)3.00971251
11Genetic anticipation (HP:0003743)2.95328292
12Myokymia (HP:0002411)2.94053088
13Action tremor (HP:0002345)2.88637707
14Short 4th metacarpal (HP:0010044)2.86171828
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.86171828
16Neurofibrillary tangles (HP:0002185)2.77700256
17Hyperventilation (HP:0002883)2.75816935
18Spastic gait (HP:0002064)2.74977399
19Inappropriate behavior (HP:0000719)2.74249646
20Scanning speech (HP:0002168)2.71083972
21Dysmetria (HP:0001310)2.68955001
22Disinhibition (HP:0000734)2.65991605
23Focal motor seizures (HP:0011153)2.64838595
24Papillary thyroid carcinoma (HP:0002895)2.63463968
25Urinary urgency (HP:0000012)2.62417667
26Urinary bladder sphincter dysfunction (HP:0002839)2.61791135
27Neoplasm of the heart (HP:0100544)2.59771400
28Broad-based gait (HP:0002136)2.59272375
29Peripheral hypomyelination (HP:0007182)2.58729433
30Truncal ataxia (HP:0002078)2.54669484
31Papilledema (HP:0001085)2.49706979
32Overriding aorta (HP:0002623)2.46734745
33Onion bulb formation (HP:0003383)2.43944432
34Abnormal respiratory motile cilium physiology (HP:0012261)2.43530624
35Spontaneous hematomas (HP:0007420)2.41425331
36Macroorchidism (HP:0000053)2.41124529
37Drooling (HP:0002307)2.40597629
38Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.39665039
39Excessive salivation (HP:0003781)2.38835111
40Absent/shortened dynein arms (HP:0200106)2.36885035
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.36885035
42Neonatal hypoglycemia (HP:0001998)2.36496065
43Ankle clonus (HP:0011448)2.34324247
44Focal seizures (HP:0007359)2.31368916
45Aqueductal stenosis (HP:0002410)2.29363813
46Apathy (HP:0000741)2.29345492
47Vertebral arch anomaly (HP:0008438)2.25672241
48Heterotopia (HP:0002282)2.24971445
49Cellulitis (HP:0100658)2.24430422
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.23094796
51Abnormal ciliary motility (HP:0012262)2.22985188
52Abnormality of the distal phalanx of the thumb (HP:0009617)2.21139254
53Hyperacusis (HP:0010780)2.19410343
54Overgrowth (HP:0001548)2.18479962
55Mutism (HP:0002300)2.17873141
56Febrile seizures (HP:0002373)2.17643113
57Progressive cerebellar ataxia (HP:0002073)2.15900923
58Sensory axonal neuropathy (HP:0003390)2.14084362
59Tented upper lip vermilion (HP:0010804)2.13990012
60Thyroiditis (HP:0100646)2.13636155
61Truncal obesity (HP:0001956)2.13395736
62Male infertility (HP:0003251)2.12609562
63Prolonged bleeding time (HP:0003010)2.12344927
64Widely spaced teeth (HP:0000687)2.12176113
65Depression (HP:0000716)2.11573992
66Increased cerebral lipofuscin (HP:0011813)2.10964116
67Abnormality of the parietal bone (HP:0002696)2.10940901
68Agammaglobulinemia (HP:0004432)2.10514246
69Epileptic encephalopathy (HP:0200134)2.10422517
70Visual hallucinations (HP:0002367)2.09183780
71Dysmetric saccades (HP:0000641)2.08971619
72Arterial tortuosity (HP:0005116)2.07939363
73Abnormality of saccadic eye movements (HP:0000570)2.07748609
74Postural instability (HP:0002172)2.07247711
75Stereotypic behavior (HP:0000733)2.06873585
76Impaired vibration sensation in the lower limbs (HP:0002166)2.05678217
77Megalencephaly (HP:0001355)2.03595355
78Dysdiadochokinesis (HP:0002075)2.02197393
79Nasal polyposis (HP:0100582)2.02100303
80Abnormality of the 4th metacarpal (HP:0010012)2.01995216
81Rhinitis (HP:0012384)2.01683091
82Hemiplegia (HP:0002301)2.01534881
83Chronic sinusitis (HP:0011109)2.01514196
84Insomnia (HP:0100785)2.01514094
85Diminished motivation (HP:0000745)2.01461560
86Gingival bleeding (HP:0000225)1.99918641
87Cerebral inclusion bodies (HP:0100314)1.99413547
88Narrow palate (HP:0000189)1.97371935
89Slow saccadic eye movements (HP:0000514)1.96345708
90Abnormality of the axillary hair (HP:0100134)1.95293298
91Abnormality of secondary sexual hair (HP:0009888)1.95293298
92Gastrointestinal stroma tumor (HP:0100723)1.95248573
93Supernumerary ribs (HP:0005815)1.94604694
94Peritonitis (HP:0002586)1.94180844
95Abnormality of the ischium (HP:0003174)1.94145384
96Impaired smooth pursuit (HP:0007772)1.93795139
97Recurrent bronchitis (HP:0002837)1.93302792
98Poor eye contact (HP:0000817)1.92801340
99Abnormality of the nasal mucosa (HP:0000433)1.91310416
100Premature skin wrinkling (HP:0100678)1.89395973
101Increased neuronal autofluorescent lipopigment (HP:0002074)1.88594170
102Broad face (HP:0000283)1.86697225
103Bladder carcinoma (HP:0002862)1.85129542
104Bladder neoplasm (HP:0009725)1.85129542
105Tapered finger (HP:0001182)1.83787996
106Absent frontal sinuses (HP:0002688)1.83003177
107Germ cell neoplasia (HP:0100728)1.82718515
108Flat acetabular roof (HP:0003180)1.81543944
109Clumsiness (HP:0002312)1.79733147
110Abnormal auditory evoked potentials (HP:0006958)1.78278803
111Sleep apnea (HP:0010535)1.77877146
112Vascular tortuosity (HP:0004948)1.77695391
113Abnormality of ocular smooth pursuit (HP:0000617)1.76977461
114Diplopia (HP:0000651)1.76847957
115Abnormality of binocular vision (HP:0011514)1.76847957
116Relative macrocephaly (HP:0004482)1.76828170
117Asplenia (HP:0001746)1.76548392
118Lower limb muscle weakness (HP:0007340)1.76455838
119Abnormality of the fingertips (HP:0001211)1.76187169
120Exotropia (HP:0000577)1.75808514
121Abnormal respiratory epithelium morphology (HP:0012253)1.75214749
122Abnormal respiratory motile cilium morphology (HP:0005938)1.75214749
123Cystic hygroma (HP:0000476)1.74362105
124Sporadic (HP:0003745)1.74108118
125Transitional cell carcinoma of the bladder (HP:0006740)1.73561038
126Eczematoid dermatitis (HP:0000976)1.73268463
127Abnormal platelet volume (HP:0011876)1.73063175
128Recurrent viral infections (HP:0004429)1.71882573
129Impaired social interactions (HP:0000735)1.70382058
130Abnormal social behavior (HP:0012433)1.70382058
131Loss of speech (HP:0002371)1.70348906
13211 pairs of ribs (HP:0000878)1.70343387
133Obsessive-compulsive behavior (HP:0000722)1.69853026
134Congenital stationary night blindness (HP:0007642)1.68400184
135Neuronal loss in central nervous system (HP:0002529)1.67336530
136Hypoplastic ischia (HP:0003175)1.66646661
137Hamartoma (HP:0010566)1.66343260
138Curly hair (HP:0002212)1.66198127
139Pointed chin (HP:0000307)1.66108600
140Abnormality of chromosome segregation (HP:0002916)1.65827390
141Abolished electroretinogram (ERG) (HP:0000550)1.65783931
142Exostoses (HP:0100777)1.65450939
143Panhypogammaglobulinemia (HP:0003139)1.65284123
144Thickened calvaria (HP:0002684)1.65269335
145Tracheomalacia (HP:0002779)1.64991881
146Absent speech (HP:0001344)1.63986989
147Subacute progressive viral hepatitis (HP:0006572)1.63223784
148Testicular neoplasm (HP:0010788)1.61001389
149Hematochezia (HP:0002573)1.60233735
150Elfin facies (HP:0004428)1.60107785
151Akinesia (HP:0002304)1.59990126
152Broad distal phalanx of finger (HP:0009836)1.59790853
153Spastic tetraparesis (HP:0001285)1.59337305
154Uterine leiomyosarcoma (HP:0002891)1.58971096
155Leiomyosarcoma (HP:0100243)1.58971096
156Abnormality of salivation (HP:0100755)1.58756496
157Supernumerary bones of the axial skeleton (HP:0009144)1.57902690
158Increased mean platelet volume (HP:0011877)1.57125670
159Lower limb asymmetry (HP:0100559)1.55648928
160Volvulus (HP:0002580)1.55531984
161Sparse lateral eyebrow (HP:0005338)1.55369040
162Morphological abnormality of the pyramidal tract (HP:0002062)1.55017461
163Thickened helices (HP:0000391)1.53810623
164Shawl scrotum (HP:0000049)1.53339439
165Cubitus valgus (HP:0002967)1.52178852
166Abnormality of the phalanges of the hallux (HP:0010057)1.50851472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.77843344
2STK393.57453188
3EEF2K3.13890077
4CDK193.03140562
5CAMK1D2.93059333
6OXSR12.86417562
7FGFR22.84655158
8TRIB32.52639495
9SGK22.48778565
10EPHB12.45475083
11MAP4K12.38523634
12MAPKAPK52.15115462
13KIT2.01623967
14FES1.94976100
15CLK11.91182236
16RIPK41.87919403
17TYRO31.80441230
18TNIK1.78734876
19EPHA41.76808068
20CASK1.74316986
21CSF1R1.72845474
22WNK11.71283098
23ICK1.60458843
24CAMKK11.56576686
25MAP2K41.55395283
26MAP3K131.52318876
27MAP3K91.51292976
28YES11.43097475
29PAK61.36243761
30UHMK11.32578787
31TRPM71.29595753
32PRPF4B1.26361311
33PDK11.20737665
34PKN11.19637559
35PKN21.18900162
36IRAK21.18127440
37ITK1.18014734
38CAMKK21.16234335
39KSR11.14458139
40SIK21.14241553
41MARK21.11428270
42CAMK1G1.11334622
43PRKCH1.10943252
44CDK121.10031649
45PDPK11.05559264
46NTRK21.05310340
47CSNK1A1L1.03945054
48MARK11.03432105
49CDK50.99721248
50RET0.97291704
51DMPK0.97263434
52STK110.96803710
53HCK0.96070490
54STK380.93294508
55SGK2230.92165430
56SGK4940.92165430
57SYK0.91398339
58BTK0.89783213
59TAOK10.89003347
60TAOK30.88015981
61FYN0.87936363
62DAPK20.86334673
63HIPK20.84915797
64NEK90.82482120
65DYRK1B0.80915106
66ROCK20.79919925
67CSNK1G20.78928393
68PDGFRB0.78132603
69MAP2K30.77997738
70KSR20.77713242
71MAP3K100.77386971
72MAP3K40.77340890
73CAMK40.76948979
74PRKD10.76663685
75MAP3K60.76582366
76JAK20.76071627
77ALK0.75947005
78GRK10.75395438
79BRD40.74299323
80LCK0.74002815
81IRAK40.73702929
82MAP3K70.73562324
83TNK20.72277706
84PRKD20.72268573
85CAMK10.71280945
86FGFR30.71208773
87CSNK1G30.70279526
88EPHA30.68501430
89NTRK10.68500226
90MAP3K20.68443643
91NEK60.68131626
92PRKCQ0.67679571
93TGFBR20.67477193
94PAK30.67337790
95BLK0.66328611
96CAMK2B0.65584182
97MATK0.65481483
98SGK30.64031437
99NTRK30.60986244
100MAPK120.60621248
101IKBKE0.58357282
102PTK60.58300063
103PNCK0.58115940
104DYRK1A0.57503501
105LRRK20.57466699
106CSK0.57234198
107ERBB20.55772983
108BRSK20.55298765
109CSNK1G10.54513796
110PRKCZ0.54150081
111STK100.54111402
112INSRR0.53958753
113IRAK10.53608610
114MAPK130.52850639
115PIK3CA0.52776814
116MAPK100.52714128
117PTK2B0.51820847
118FGR0.51740571
119MELK0.51066491
120CDK150.50840409
121MINK10.50060113
122JAK10.49450031
123CCNB10.48657214
124PRKD30.47804102
125RPS6KA20.47397708
126SCYL20.46526093
127CDK180.44510558
128CDK11A0.43921737
129SGK10.42839199
130LYN0.42677455
131SIK10.42234865
132PHKG20.41913157
133PHKG10.41913157
134TYK20.41570793
135CDK140.40987508
136RIPK10.40671964
137TAF10.39914820
138PDGFRA0.39728212
139RAF10.37788273
140FER0.37527286
141DDR20.34147422
142NLK0.34013900

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.00066040
2B cell receptor signaling pathway_Homo sapiens_hsa046621.81406425
3Glutamatergic synapse_Homo sapiens_hsa047241.78987505
4Circadian entrainment_Homo sapiens_hsa047131.64449780
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63691081
6Olfactory transduction_Homo sapiens_hsa047401.62645161
7Long-term potentiation_Homo sapiens_hsa047201.61839119
8Morphine addiction_Homo sapiens_hsa050321.54959696
9Gastric acid secretion_Homo sapiens_hsa049711.54438721
10Salivary secretion_Homo sapiens_hsa049701.50371329
11Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46892931
12Fatty acid biosynthesis_Homo sapiens_hsa000611.32966600
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32809235
14Cholinergic synapse_Homo sapiens_hsa047251.31385245
15Long-term depression_Homo sapiens_hsa047301.31078664
16Axon guidance_Homo sapiens_hsa043601.26398788
17Platelet activation_Homo sapiens_hsa046111.26167129
18GABAergic synapse_Homo sapiens_hsa047271.25170022
19Prostate cancer_Homo sapiens_hsa052151.25128831
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25001133
21Osteoclast differentiation_Homo sapiens_hsa043801.24647165
22Renin secretion_Homo sapiens_hsa049241.23295883
23Oxytocin signaling pathway_Homo sapiens_hsa049211.22672673
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22310587
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22167853
26T cell receptor signaling pathway_Homo sapiens_hsa046601.21032161
27Chemokine signaling pathway_Homo sapiens_hsa040621.20654691
28Phospholipase D signaling pathway_Homo sapiens_hsa040721.20593406
29Dopaminergic synapse_Homo sapiens_hsa047281.20328359
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19012694
31Primary immunodeficiency_Homo sapiens_hsa053401.17987169
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15933103
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15901331
34ErbB signaling pathway_Homo sapiens_hsa040121.14415163
35Dorso-ventral axis formation_Homo sapiens_hsa043201.14387044
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12362927
37Renal cell carcinoma_Homo sapiens_hsa052111.12104427
38Endocytosis_Homo sapiens_hsa041441.12028929
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.11498304
40Amphetamine addiction_Homo sapiens_hsa050311.11194834
41FoxO signaling pathway_Homo sapiens_hsa040681.11151068
42cAMP signaling pathway_Homo sapiens_hsa040241.07064354
43Nicotine addiction_Homo sapiens_hsa050331.06783918
44GnRH signaling pathway_Homo sapiens_hsa049121.06632622
45Notch signaling pathway_Homo sapiens_hsa043301.05228545
46Sphingolipid signaling pathway_Homo sapiens_hsa040711.05056889
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.04942353
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04501471
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04360244
50Glioma_Homo sapiens_hsa052141.04210504
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04026096
52VEGF signaling pathway_Homo sapiens_hsa043701.03509331
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03499438
54Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03136157
55Non-small cell lung cancer_Homo sapiens_hsa052231.02105740
56Chronic myeloid leukemia_Homo sapiens_hsa052200.97984772
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.97064037
58Synaptic vesicle cycle_Homo sapiens_hsa047210.96338564
59MAPK signaling pathway_Homo sapiens_hsa040100.93441603
60Cocaine addiction_Homo sapiens_hsa050300.93362446
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93143939
62Inositol phosphate metabolism_Homo sapiens_hsa005620.92211120
63Gap junction_Homo sapiens_hsa045400.91808477
64Estrogen signaling pathway_Homo sapiens_hsa049150.89849526
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89708317
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89222310
67Calcium signaling pathway_Homo sapiens_hsa040200.88410104
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87987455
69Choline metabolism in cancer_Homo sapiens_hsa052310.86276473
70Pancreatic cancer_Homo sapiens_hsa052120.82807314
71Melanogenesis_Homo sapiens_hsa049160.82246472
72Leishmaniasis_Homo sapiens_hsa051400.80607791
73Rap1 signaling pathway_Homo sapiens_hsa040150.80177025
74Salmonella infection_Homo sapiens_hsa051320.79145693
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78878410
76Serotonergic synapse_Homo sapiens_hsa047260.78845622
77Insulin signaling pathway_Homo sapiens_hsa049100.78539327
78Toxoplasmosis_Homo sapiens_hsa051450.77350254
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77273306
80Ras signaling pathway_Homo sapiens_hsa040140.77149044
81Colorectal cancer_Homo sapiens_hsa052100.75519678
82Hematopoietic cell lineage_Homo sapiens_hsa046400.75072484
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74455129
84Pancreatic secretion_Homo sapiens_hsa049720.73787136
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.72669545
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72566357
87Tuberculosis_Homo sapiens_hsa051520.72182474
88Acute myeloid leukemia_Homo sapiens_hsa052210.71839166
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71561558
90MicroRNAs in cancer_Homo sapiens_hsa052060.70372613
91Type II diabetes mellitus_Homo sapiens_hsa049300.69741633
92Thyroid hormone synthesis_Homo sapiens_hsa049180.68814488
93Endometrial cancer_Homo sapiens_hsa052130.67735982
94Ether lipid metabolism_Homo sapiens_hsa005650.67503270
95Thyroid cancer_Homo sapiens_hsa052160.66980378
96Melanoma_Homo sapiens_hsa052180.66144432
97Shigellosis_Homo sapiens_hsa051310.64895930
98Proteoglycans in cancer_Homo sapiens_hsa052050.64598821
99Taste transduction_Homo sapiens_hsa047420.63158607
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63083570
101AMPK signaling pathway_Homo sapiens_hsa041520.63001621
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62552538
103Bile secretion_Homo sapiens_hsa049760.61900086
104Focal adhesion_Homo sapiens_hsa045100.61685316
105Alcoholism_Homo sapiens_hsa050340.60546592
106Hedgehog signaling pathway_Homo sapiens_hsa043400.60031401
107mTOR signaling pathway_Homo sapiens_hsa041500.59895464
108Adherens junction_Homo sapiens_hsa045200.59502333
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.59014383
110African trypanosomiasis_Homo sapiens_hsa051430.58590152
111Insulin secretion_Homo sapiens_hsa049110.58541319
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58389599
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58295106
114HIF-1 signaling pathway_Homo sapiens_hsa040660.58282866
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57910883
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57467549
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.57375652
118Prolactin signaling pathway_Homo sapiens_hsa049170.56513332
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56277818
120Hepatitis B_Homo sapiens_hsa051610.56056347
121Insulin resistance_Homo sapiens_hsa049310.55273745
122Measles_Homo sapiens_hsa051620.54419389
123Pathways in cancer_Homo sapiens_hsa052000.53425545
124Hepatitis C_Homo sapiens_hsa051600.52690883

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