CDK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.31687281
2DNA unwinding involved in DNA replication (GO:0006268)5.21919005
3DNA strand elongation (GO:0022616)5.05477500
4telomere maintenance via semi-conservative replication (GO:0032201)5.00771874
5DNA replication initiation (GO:0006270)5.00155145
6ribosomal small subunit assembly (GO:0000028)4.54183132
7pore complex assembly (GO:0046931)4.52124646
8protein localization to kinetochore (GO:0034501)4.50342488
9telomere maintenance via recombination (GO:0000722)4.46342863
10mitotic recombination (GO:0006312)4.26657192
11regulation of sister chromatid cohesion (GO:0007063)4.19792018
12mitotic sister chromatid cohesion (GO:0007064)4.19427645
13chromosome condensation (GO:0030261)4.17413013
14DNA topological change (GO:0006265)4.11828972
15DNA replication checkpoint (GO:0000076)4.02648621
16nucleobase biosynthetic process (GO:0046112)4.02294599
17protein localization to chromosome, centromeric region (GO:0071459)3.85479790
18telomere maintenance via telomere lengthening (GO:0010833)3.84307194
19formation of translation preinitiation complex (GO:0001731)3.83530256
20maturation of SSU-rRNA (GO:0030490)3.83418495
21DNA replication-dependent nucleosome assembly (GO:0006335)3.83212917
22DNA replication-dependent nucleosome organization (GO:0034723)3.83212917
23regulation of translational fidelity (GO:0006450)3.78423435
24purine nucleobase biosynthetic process (GO:0009113)3.77391527
25regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76752963
26COPI coating of Golgi vesicle (GO:0048205)3.76612933
27Golgi transport vesicle coating (GO:0048200)3.76612933
28viral transcription (GO:0019083)3.75473800
29DNA deamination (GO:0045006)3.75275640
30nucleotide-excision repair, DNA gap filling (GO:0006297)3.72699021
31regulation of mitotic spindle organization (GO:0060236)3.70660399
32translational termination (GO:0006415)3.67183757
33mitotic nuclear envelope disassembly (GO:0007077)3.66562823
34IMP biosynthetic process (GO:0006188)3.61405821
35establishment of integrated proviral latency (GO:0075713)3.60579403
36mitotic metaphase plate congression (GO:0007080)3.57056192
37folic acid-containing compound biosynthetic process (GO:0009396)3.56453244
38DNA packaging (GO:0006323)3.55838324
39melanin biosynthetic process (GO:0042438)3.54114690
40CENP-A containing nucleosome assembly (GO:0034080)3.51522466
41chromosome segregation (GO:0007059)3.49406762
42chromatin remodeling at centromere (GO:0031055)3.46595930
43translational elongation (GO:0006414)3.40719339
44pigment biosynthetic process (GO:0046148)3.37416697
45mitotic chromosome condensation (GO:0007076)3.37137138
46DNA replication-independent nucleosome organization (GO:0034724)3.36114747
47DNA replication-independent nucleosome assembly (GO:0006336)3.36114747
48melanin metabolic process (GO:0006582)3.35988111
49membrane disassembly (GO:0030397)3.35971644
50nuclear envelope disassembly (GO:0051081)3.35971644
51nucleobase-containing small molecule interconversion (GO:0015949)3.33441816
52DNA duplex unwinding (GO:0032508)3.32007202
53protein complex localization (GO:0031503)3.31792518
54IMP metabolic process (GO:0046040)3.30731274
55DNA geometric change (GO:0032392)3.30006256
56ribosomal small subunit biogenesis (GO:0042274)3.29906667
57translational initiation (GO:0006413)3.28314869
58nuclear pore organization (GO:0006999)3.25494889
59translesion synthesis (GO:0019985)3.25144785
60mitotic sister chromatid segregation (GO:0000070)3.21487072
61heterochromatin organization (GO:0070828)3.21353004
62kinetochore organization (GO:0051383)3.19391371
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18583387
64metaphase plate congression (GO:0051310)3.18367777
65negative regulation of mRNA processing (GO:0050686)3.16245482
66non-recombinational repair (GO:0000726)3.12618502
67double-strand break repair via nonhomologous end joining (GO:0006303)3.12618502
68attachment of spindle microtubules to kinetochore (GO:0008608)3.12548305
69regulation of spindle organization (GO:0090224)3.10794232
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10302138
71DNA ligation (GO:0006266)3.09945239
72spliceosomal tri-snRNP complex assembly (GO:0000244)3.08346864
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.07675289
74ribonucleoprotein complex biogenesis (GO:0022613)3.06459713
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05423153
76telomere maintenance (GO:0000723)3.05067505
77nuclear pore complex assembly (GO:0051292)3.04787338
78ribosome biogenesis (GO:0042254)3.04704790
79telomere organization (GO:0032200)3.03869388
80negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03270051
81cellular protein complex localization (GO:0034629)3.02716949
82ribosomal large subunit biogenesis (GO:0042273)3.02090722
83ribosome assembly (GO:0042255)3.00842247
84sister chromatid segregation (GO:0000819)3.00533346
85cotranslational protein targeting to membrane (GO:0006613)2.97423416
86DNA synthesis involved in DNA repair (GO:0000731)2.97017520
87protein targeting to ER (GO:0045047)2.96938648
88somatic hypermutation of immunoglobulin genes (GO:0016446)2.95567746
89somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95567746
90regulation of translational termination (GO:0006449)2.95494428
91postreplication repair (GO:0006301)2.94552593
92regulation of histone H3-K9 methylation (GO:0051570)2.93781388
93dosage compensation (GO:0007549)2.92645354
94histone exchange (GO:0043486)2.92600855
95establishment of chromosome localization (GO:0051303)2.91962595
96negative regulation of RNA splicing (GO:0033119)2.91791162
97deoxyribonucleotide biosynthetic process (GO:0009263)2.90588865
98chromatin assembly or disassembly (GO:0006333)2.88960791
99viral life cycle (GO:0019058)2.86465279
100regulation of double-strand break repair via homologous recombination (GO:0010569)2.84705409
101secondary metabolite biosynthetic process (GO:0044550)2.84195122
102mismatch repair (GO:0006298)2.83858877
103DNA conformation change (GO:0071103)2.83791922
104negative regulation of mRNA metabolic process (GO:1903312)2.83511803
105cellular protein complex disassembly (GO:0043624)2.82433128
106establishment of protein localization to endoplasmic reticulum (GO:0072599)2.82352735
107rRNA processing (GO:0006364)2.81751969
108positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.81272849
109positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.81272849
110positive regulation of mitotic sister chromatid separation (GO:1901970)2.81272849
111kinetochore assembly (GO:0051382)2.80535761
112meiotic chromosome segregation (GO:0045132)2.79233137
113regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.78706929
114protein localization to endoplasmic reticulum (GO:0070972)2.77934732
115* mitotic cell cycle (GO:0000278)2.77380717
116spindle checkpoint (GO:0031577)2.77231215
117regulation of mammary gland epithelial cell proliferation (GO:0033599)2.77089001
118establishment of viral latency (GO:0019043)2.76501879
119tyrosine metabolic process (GO:0006570)2.76430857
120protein export from nucleus (GO:0006611)2.76266551
121regulation of RNA export from nucleus (GO:0046831)2.75680682
122proline biosynthetic process (GO:0006561)2.75350727
123positive regulation of chromosome segregation (GO:0051984)2.74897813
124base-excision repair (GO:0006284)2.73992347
125transcription-coupled nucleotide-excision repair (GO:0006283)2.73551365
126regulation of DNA endoreduplication (GO:0032875)2.73198772
127protein K6-linked ubiquitination (GO:0085020)2.72719676
128regulation of chromosome segregation (GO:0051983)2.71787351
129* cell cycle G1/S phase transition (GO:0044843)2.71674067
130* G1/S transition of mitotic cell cycle (GO:0000082)2.71674067
131folic acid metabolic process (GO:0046655)2.71488231
132rRNA metabolic process (GO:0016072)2.71440842
133nuclear envelope organization (GO:0006998)2.70975916
134spliceosomal snRNP assembly (GO:0000387)2.69849884
135regulation of centriole replication (GO:0046599)2.69294808
136protein localization to chromosome (GO:0034502)2.69031866
137viral mRNA export from host cell nucleus (GO:0046784)2.68555054
138maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66787081
139nuclear-transcribed mRNA catabolic process (GO:0000956)2.66316867
140protein complex disassembly (GO:0043241)2.66293494
141negative regulation of chromosome segregation (GO:0051985)2.65188811
142melanocyte differentiation (GO:0030318)2.62578305
143regulation of centrosome cycle (GO:0046605)2.60989246
144mitotic spindle checkpoint (GO:0071174)2.60909393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.43339823
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.96196520
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.76826174
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56785772
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56215633
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01046453
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62817234
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49886550
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49017725
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.37619614
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.33549533
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29368400
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.21551841
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.16081890
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15281802
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14425550
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13037347
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12372214
19XRN2_22483619_ChIP-Seq_HELA_Human2.07967780
20MYC_22102868_ChIP-Seq_BL_Human2.04057301
21* AR_21909140_ChIP-Seq_LNCAP_Human2.03475691
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03103785
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.02318537
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99486628
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94421380
26VDR_23849224_ChIP-Seq_CD4+_Human1.92535850
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91014782
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81947955
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80225690
30ZNF263_19887448_ChIP-Seq_K562_Human1.79960501
31FOXP3_21729870_ChIP-Seq_TREG_Human1.77057498
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76503364
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74924938
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73192200
35CIITA_25753668_ChIP-Seq_RAJI_Human1.66450271
36DCP1A_22483619_ChIP-Seq_HELA_Human1.64851439
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62808170
38GABP_19822575_ChIP-Seq_HepG2_Human1.60392248
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57513355
40VDR_21846776_ChIP-Seq_THP-1_Human1.56182362
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54193101
42TTF2_22483619_ChIP-Seq_HELA_Human1.53381048
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49628764
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45853672
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45150505
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43335748
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42848061
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42381230
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39479792
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38441199
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38066377
52ELK1_19687146_ChIP-ChIP_HELA_Human1.37785121
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37209325
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37187170
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36680421
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36458334
57CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35902550
58KDM5A_27292631_Chip-Seq_BREAST_Human1.33031916
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.32086431
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27424760
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26759590
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25446294
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.22191911
64SPI1_23547873_ChIP-Seq_NB4_Human1.21906050
65TFEB_21752829_ChIP-Seq_HELA_Human1.21428481
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20912979
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.20894054
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20678957
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19097357
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18530407
71* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16748445
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16372071
73SCL_19346495_ChIP-Seq_HPC-7_Human1.14980438
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12303488
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11804140
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.11772419
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11130624
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.09621468
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09368013
80CLOCK_20551151_ChIP-Seq_293T_Human1.09331514
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09244652
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.08738132
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.08473179
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08414018
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06297311
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04789094
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02285528
88CHD1_26751641_Chip-Seq_LNCaP_Human0.98813559
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.98700071
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98423153
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98260166
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97135103
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96473089
94* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95520217
95HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95000414
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94910386
97RACK7_27058665_Chip-Seq_MCF-7_Human0.94002460
98* SOX17_20123909_ChIP-Seq_XEN_Mouse0.93770849
99NANOG_21062744_ChIP-ChIP_HESCs_Human0.93504466
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93410072
101SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93383914
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92682556
103PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92266013
104MAF_26560356_Chip-Seq_TH1_Human0.91640307
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91227911
106UTX_26944678_Chip-Seq_JUKART_Human0.90804630
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90365300
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89805703
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89176866
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88671204
111MYB_26560356_Chip-Seq_TH1_Human0.88141749
112* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86748500
113PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86596233
114NCOR1_26117541_ChIP-Seq_K562_Human0.86566246
115MYB_26560356_Chip-Seq_TH2_Human0.86562389
116RUNX1_22412390_ChIP-Seq_EML_Mouse0.85864937
117* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84684367
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84654932
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84107323
120BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83996620
121* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83603242
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83535042
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82995248
124RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82890386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.28086741
2MP0003693_abnormal_embryo_hatching4.25865222
3MP0003111_abnormal_nucleus_morphology3.76200780
4MP0004957_abnormal_blastocyst_morpholog3.42909358
5MP0008057_abnormal_DNA_replication3.42563046
6* MP0003077_abnormal_cell_cycle3.28190114
7MP0000372_irregular_coat_pigmentation3.08656401
8MP0002396_abnormal_hematopoietic_system2.78567721
9MP0008058_abnormal_DNA_repair2.54649164
10MP0008007_abnormal_cellular_replicative2.51717896
11MP0010352_gastrointestinal_tract_polyps2.26343476
12MP0010234_abnormal_vibrissa_follicle1.93254281
13MP0008932_abnormal_embryonic_tissue1.90344979
14MP0010307_abnormal_tumor_latency1.89910202
15MP0000490_abnormal_crypts_of1.87965171
16MP0001730_embryonic_growth_arrest1.86965841
17MP0005075_abnormal_melanosome_morpholog1.86220543
18* MP0000350_abnormal_cell_proliferation1.81291674
19* MP0004808_abnormal_hematopoietic_stem1.76818049
20MP0005171_absent_coat_pigmentation1.73611994
21MP0002095_abnormal_skin_pigmentation1.72388000
22MP0000371_diluted_coat_color1.71317028
23MP0001545_abnormal_hematopoietic_system1.68876148
24MP0005397_hematopoietic_system_phenotyp1.68876148
25MP0005174_abnormal_tail_pigmentation1.65761526
26MP0003786_premature_aging1.59658140
27MP0005408_hypopigmentation1.57913429
28MP0006054_spinal_hemorrhage1.46971960
29MP0003123_paternal_imprinting1.43127095
30MP0004233_abnormal_muscle_weight1.41092667
31* MP0002019_abnormal_tumor_incidence1.39435129
32MP0002877_abnormal_melanocyte_morpholog1.38775837
33MP0003763_abnormal_thymus_physiology1.38770655
34MP0010030_abnormal_orbit_morphology1.37825751
35* MP0005380_embryogenesis_phenotype1.36805677
36* MP0001672_abnormal_embryogenesis/_devel1.36805677
37MP0008438_abnormal_cutaneous_collagen1.36237455
38* MP0001697_abnormal_embryo_size1.35728547
39* MP0002080_prenatal_lethality1.33854288
40* MP0002398_abnormal_bone_marrow1.33749352
41MP0008877_abnormal_DNA_methylation1.33603573
42MP0000313_abnormal_cell_death1.33281583
43MP0009333_abnormal_splenocyte_physiolog1.32451916
44MP0000015_abnormal_ear_pigmentation1.32377177
45MP0005409_darkened_coat_color1.31586336
46MP0000537_abnormal_urethra_morphology1.31305600
47MP0002075_abnormal_coat/hair_pigmentati1.31237822
48MP0009278_abnormal_bone_marrow1.29597911
49MP0003984_embryonic_growth_retardation1.28970091
50MP0002722_abnormal_immune_system1.26797789
51MP0002088_abnormal_embryonic_growth/wei1.26121744
52MP0000689_abnormal_spleen_morphology1.24384360
53MP0004381_abnormal_hair_follicle1.22698283
54MP0005377_hearing/vestibular/ear_phenot1.22185810
55MP0003878_abnormal_ear_physiology1.22185810
56MP0002086_abnormal_extraembryonic_tissu1.21782949
57MP0009697_abnormal_copulation1.21530801
58MP0004197_abnormal_fetal_growth/weight/1.21485160
59MP0000703_abnormal_thymus_morphology1.20230332
60MP0001324_abnormal_eye_pigmentation1.19832295
61MP0003136_yellow_coat_color1.17470118
62MP0001293_anophthalmia1.16480961
63MP0002085_abnormal_embryonic_tissue1.13832788
64MP0005248_abnormal_Harderian_gland1.13295527
65MP0005197_abnormal_uvea_morphology1.12540130
66MP0001849_ear_inflammation1.10949413
67MP0000685_abnormal_immune_system1.10221805
68MP0002084_abnormal_developmental_patter1.09336439
69MP0005451_abnormal_body_composition1.07668496
70MP0001835_abnormal_antigen_presentation1.07035837
71* MP0002429_abnormal_blood_cell1.05301056
72MP0005023_abnormal_wound_healing0.97812450
73MP0005076_abnormal_cell_differentiation0.97551830
74MP0000716_abnormal_immune_system0.96194203
75MP0009672_abnormal_birth_weight0.95432519
76* MP0003567_abnormal_fetal_cardiomyocyte0.94711539
77MP0000465_gastrointestinal_hemorrhage0.93684956
78MP0001186_pigmentation_phenotype0.93558334
79MP0005058_abnormal_lysosome_morphology0.93002447
80MP0002166_altered_tumor_susceptibility0.92787442
81MP0003705_abnormal_hypodermis_morpholog0.92270150
82MP0002938_white_spotting0.92070747
83MP0001800_abnormal_humoral_immune0.91858149
84MP0002697_abnormal_eye_size0.90886051
85MP0000858_altered_metastatic_potential0.90503807
86* MP0002210_abnormal_sex_determination0.89837953
87MP0002009_preneoplasia0.89470899
88MP0001853_heart_inflammation0.88645372
89MP0002452_abnormal_antigen_presenting0.87663538
90MP0002420_abnormal_adaptive_immunity0.86642783
91MP0001819_abnormal_immune_cell0.85235443
92MP0003566_abnormal_cell_adhesion0.84342684
93MP0002102_abnormal_ear_morphology0.83198520
94MP0004272_abnormal_basement_membrane0.82987210
95MP0000358_abnormal_cell_content/0.82591066
96MP0003718_maternal_effect0.82562101
97* MP0001145_abnormal_male_reproductive0.81145776
98MP0002060_abnormal_skin_morphology0.80517375
99MP0002089_abnormal_postnatal_growth/wei0.79651334
100MP0004185_abnormal_adipocyte_glucose0.78914765
101MP0002405_respiratory_system_inflammati0.78077816
102MP0008260_abnormal_autophagy0.77965130
103MP0005623_abnormal_meninges_morphology0.77303407
104MP0002177_abnormal_outer_ear0.76412943
105MP0005501_abnormal_skin_physiology0.75679395
106MP0005464_abnormal_platelet_physiology0.75413231
107MP0009053_abnormal_anal_canal0.75369910
108MP0005257_abnormal_intraocular_pressure0.73194260
109MP0002006_tumorigenesis0.72865920
110MP0001915_intracranial_hemorrhage0.72226629
111MP0005671_abnormal_response_to0.72089488
112* MP0001929_abnormal_gametogenesis0.72035432
113MP0003385_abnormal_body_wall0.71823369
114MP0005025_abnormal_response_to0.71135762
115MP0003943_abnormal_hepatobiliary_system0.69975095
116MP0003806_abnormal_nucleotide_metabolis0.69702520
117MP0002723_abnormal_immune_serum0.69499588
118MP0002132_abnormal_respiratory_system0.68841492
119MP0001873_stomach_inflammation0.68766016
120MP0003315_abnormal_perineum_morphology0.68537714
121MP0000377_abnormal_hair_follicle0.68514371
122MP0001346_abnormal_lacrimal_gland0.67868829
123MP0000733_abnormal_muscle_development0.67672371
124MP0009785_altered_susceptibility_to0.67637080
125MP0005384_cellular_phenotype0.67265448
126MP0001661_extended_life_span0.67246869
127MP0000477_abnormal_intestine_morphology0.66897868
128MP0005621_abnormal_cell_physiology0.66814625
129MP0003436_decreased_susceptibility_to0.66342550
130* MP0002092_abnormal_eye_morphology0.65794544
131MP0003453_abnormal_keratinocyte_physiol0.65104627
132MP0001348_abnormal_lacrimal_gland0.57292083
133MP0002090_abnormal_vision0.55786423
134MP0003937_abnormal_limbs/digits/tail_de0.55660482
135MP0000428_abnormal_craniofacial_morphol0.53038853
136MP0000003_abnormal_adipose_tissue0.52655633
137MP0002098_abnormal_vibrissa_morphology0.52220797
138MP0005193_abnormal_anterior_eye0.51226924
139MP0004264_abnormal_extraembryonic_tissu0.50386871
140MP0002796_impaired_skin_barrier0.49290391
141MP0000627_abnormal_mammary_gland0.49235264
142MP0003221_abnormal_cardiomyocyte_apopto0.48081524

Predicted human phenotypes

RankGene SetZ-score
1White forelock (HP:0002211)5.17857545
2Patchy hypopigmentation of hair (HP:0011365)4.75303123
3Reticulocytopenia (HP:0001896)4.34847394
4Birth length less than 3rd percentile (HP:0003561)4.11086586
5Abnormality of cells of the erythroid lineage (HP:0012130)3.89356587
6Abnormal number of erythroid precursors (HP:0012131)3.78624504
7Blue irides (HP:0000635)3.44491134
8Selective tooth agenesis (HP:0001592)3.42807895
9Chromsome breakage (HP:0040012)3.40325725
10Abnormality of the fovea (HP:0000493)3.37723109
11Aplastic anemia (HP:0001915)3.35661561
12Cholecystitis (HP:0001082)3.34841695
13Abnormal gallbladder physiology (HP:0012438)3.34841695
14Iris hypopigmentation (HP:0007730)3.33834665
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.21701139
16Colon cancer (HP:0003003)3.21679419
17Thrombocytosis (HP:0001894)3.02231131
18Breast hypoplasia (HP:0003187)3.00689181
19Abnormal auditory evoked potentials (HP:0006958)2.94755904
20Oral leukoplakia (HP:0002745)2.93253007
21Abnormality of chromosome stability (HP:0003220)2.86078133
22Ependymoma (HP:0002888)2.84925661
23Heterochromia iridis (HP:0001100)2.83851034
24Premature graying of hair (HP:0002216)2.80080013
25Myelodysplasia (HP:0002863)2.78924208
26Patellar aplasia (HP:0006443)2.74193776
27IgM deficiency (HP:0002850)2.72084238
28Meckel diverticulum (HP:0002245)2.69593617
29Agnosia (HP:0010524)2.67685655
30Medulloblastoma (HP:0002885)2.64029560
31Hyperacusis (HP:0010780)2.63014754
32Pallor (HP:0000980)2.62561445
3311 pairs of ribs (HP:0000878)2.61436636
34Abnormality of the ileum (HP:0001549)2.58911943
35Aplasia/Hypoplasia of the patella (HP:0006498)2.56219781
36Abnormality of the preputium (HP:0100587)2.56072235
37Rhabdomyosarcoma (HP:0002859)2.55825891
38Degeneration of anterior horn cells (HP:0002398)2.52663359
39Abnormality of the anterior horn cell (HP:0006802)2.52663359
40Cutaneous melanoma (HP:0012056)2.51680364
41Macrocytic anemia (HP:0001972)2.47794149
42Basal cell carcinoma (HP:0002671)2.44628429
43Carpal bone hypoplasia (HP:0001498)2.41782908
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.41109294
45Absent thumb (HP:0009777)2.38504266
46Bone marrow hypocellularity (HP:0005528)2.33100740
47Aplasia/Hypoplasia of the macula (HP:0008059)2.30914580
48Deep philtrum (HP:0002002)2.30617919
49Neoplasm of the pancreas (HP:0002894)2.26025781
50Freckling (HP:0001480)2.25283191
51Premature rupture of membranes (HP:0001788)2.24811925
52Microretrognathia (HP:0000308)2.22850412
53Duodenal stenosis (HP:0100867)2.21182866
54Small intestinal stenosis (HP:0012848)2.21182866
55Hypoplasia of the iris (HP:0007676)2.20837876
56Nephroblastoma (Wilms tumor) (HP:0002667)2.19729680
57Multiple enchondromatosis (HP:0005701)2.18076311
58Amaurosis fugax (HP:0100576)2.16518476
59Impulsivity (HP:0100710)2.15974805
60Lymphoma (HP:0002665)2.15503562
61Abnormality of glycolysis (HP:0004366)2.15267128
62High pitched voice (HP:0001620)2.12114642
63Asymmetry of the thorax (HP:0001555)2.09442182
64Microvesicular hepatic steatosis (HP:0001414)2.08678791
65Rough bone trabeculation (HP:0100670)2.08075285
66Ulnar bowing (HP:0003031)2.07112328
67Orthostatic hypotension (HP:0001278)2.04958125
68Ectopic kidney (HP:0000086)2.04060953
69Sloping forehead (HP:0000340)2.03628551
70Morphological abnormality of the inner ear (HP:0011390)2.03274117
71Vertebral compression fractures (HP:0002953)2.02593840
72Slender long bone (HP:0003100)2.02523532
73Type I transferrin isoform profile (HP:0003642)2.02110904
74Embryonal renal neoplasm (HP:0011794)2.02081329
75Prominent nose (HP:0000448)2.01982325
76Tracheoesophageal fistula (HP:0002575)2.01300061
77Aplasia/Hypoplasia affecting the retina (HP:0008061)1.99491435
78Petechiae (HP:0000967)1.99055451
79Squamous cell carcinoma (HP:0002860)1.98894996
80Generalized hypopigmentation (HP:0007513)1.97743816
81Ankyloglossia (HP:0010296)1.97389221
82Increased nuchal translucency (HP:0010880)1.97201916
83Abnormality of T cell physiology (HP:0011840)1.97198220
84Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.96149580
85Absent epiphyses (HP:0010577)1.96149580
86Abnormality of the carotid arteries (HP:0005344)1.94079150
87Abnormality of reticulocytes (HP:0004312)1.93081904
88Insomnia (HP:0100785)1.92484597
89Hypoplasia of the fovea (HP:0007750)1.92060699
90Aplasia/Hypoplasia of the fovea (HP:0008060)1.92060699
91Facial cleft (HP:0002006)1.90702292
92Achilles tendon contracture (HP:0001771)1.89923506
93Abnormal number of incisors (HP:0011064)1.89882229
94Poor head control (HP:0002421)1.88696262
95Ocular albinism (HP:0001107)1.88244613
96Progressive muscle weakness (HP:0003323)1.87940110
97Atresia of the external auditory canal (HP:0000413)1.87877457
98Poikiloderma (HP:0001029)1.87072307
99Proximal placement of thumb (HP:0009623)1.86988706
100Reduced antithrombin III activity (HP:0001976)1.86393013
101Abnormality of the umbilical cord (HP:0010881)1.86199484
102Absent radius (HP:0003974)1.85788789
103Pancytopenia (HP:0001876)1.85456755
104Clubbing of toes (HP:0100760)1.85429666
105Neoplasm of striated muscle (HP:0009728)1.85248729
106Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83597191
107Cortical dysplasia (HP:0002539)1.82847583
108Trismus (HP:0000211)1.82404215
109Flared metaphyses (HP:0003015)1.80802024
110Uterine leiomyosarcoma (HP:0002891)1.80583137
111Leiomyosarcoma (HP:0100243)1.80583137
112Hypopigmentation of the fundus (HP:0007894)1.79741629
113Abnormality of oral frenula (HP:0000190)1.79628491
114Abnormality of the duodenum (HP:0002246)1.79583117
115Cafe-au-lait spot (HP:0000957)1.79508966
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78997086
117Acute myeloid leukemia (HP:0004808)1.78851183
118Recurrent viral infections (HP:0004429)1.78176964
119Melanoma (HP:0002861)1.78129670
120Spastic paraparesis (HP:0002313)1.77632507
121Cellular immunodeficiency (HP:0005374)1.77520707
122Abnormality of DNA repair (HP:0003254)1.76672805
123Deviation of the thumb (HP:0009603)1.76483467
124Abnormal umbilical cord blood vessels (HP:0011403)1.76268357
125Single umbilical artery (HP:0001195)1.76268357
126Abnormality of the fetal cardiovascular system (HP:0010948)1.76268357
127Abnormal lung lobation (HP:0002101)1.76251032
128Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75781315
129Short 4th metacarpal (HP:0010044)1.75781315
130Protrusio acetabuli (HP:0003179)1.75496179
131Albinism (HP:0001022)1.73426431
132Upper limb muscle weakness (HP:0003484)1.73012815
133Overlapping toe (HP:0001845)1.72649409
134Chronic otitis media (HP:0000389)1.72567868
135Abnormality of T cells (HP:0002843)1.72425845
136Missing ribs (HP:0000921)1.71850779
137Triphalangeal thumb (HP:0001199)1.70877313
138Abnormality of chromosome segregation (HP:0002916)1.70353495
139High anterior hairline (HP:0009890)1.69842142
140Entropion (HP:0000621)1.69789724
141Aplasia involving forearm bones (HP:0009822)1.68297594
142Absent forearm bone (HP:0003953)1.68297594
143B lymphocytopenia (HP:0010976)1.68179880
144Abnormality of B cell number (HP:0010975)1.68179880
145Neoplasm of the oral cavity (HP:0100649)1.68065048
146Cellulitis (HP:0100658)1.68050527
147Abnormality of the distal phalanges of the toes (HP:0010182)1.67883356
148Termporal pattern (HP:0011008)1.65972924
149Insidious onset (HP:0003587)1.65972924
150Progressive external ophthalmoplegia (HP:0000590)1.65759623
151Embryonal neoplasm (HP:0002898)1.63813422
152Reticulocytosis (HP:0001923)1.63537483
153Elbow flexion contracture (HP:0002987)1.63501476
154Bilateral sensorineural hearing impairment (HP:0008619)1.60678972
155Septate vagina (HP:0001153)1.59648123
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.59247676
157Osteolytic defects of the hand bones (HP:0009699)1.59247676
158Abnormality of the Achilles tendon (HP:0005109)1.57584507
159Abnormality of the calcaneus (HP:0008364)1.54614381
160Choanal atresia (HP:0000453)1.54212972
161Abnormal autonomic nervous system physiology (HP:0012332)1.54108888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.90446025
2BUB13.78893374
3* WEE13.59503470
4NEK22.90164086
5SMG12.80177646
6ICK2.29851787
7BRSK22.23822799
8EEF2K2.18920293
9ACVR1B2.18355136
10NME22.15647787
11EIF2AK12.12623827
12RPS6KB22.05415626
13PBK1.99632644
14NEK11.95811861
15PKN21.91943428
16VRK21.90656951
17TTK1.82244826
18SRPK11.81578005
19EIF2AK31.81446196
20MAP4K11.73711620
21FLT31.64700010
22ATR1.62973496
23PLK11.61454108
24CDK41.61121549
25TESK21.57070879
26MAP3K101.54096821
27PDK21.51807508
28MST1R1.51546585
29TGFBR11.51214381
30DYRK31.50748789
31* CDK71.50630091
32MKNK11.47054414
33STK101.47011097
34PLK41.46541984
35AURKB1.45267045
36CDK121.45238135
37PASK1.44228080
38VRK11.43678984
39RPS6KA41.41687410
40STK161.40262577
41TLK11.38333472
42SCYL21.37275518
43EPHA21.37059150
44TSSK61.36932563
45PAK41.36360157
46STK41.33944570
47MAP3K81.31643201
48BRSK11.28194258
49KDR1.27278886
50CHEK21.26947133
51IRAK31.26594005
52LATS21.20225063
53KIT1.20024048
54PIM11.17069908
55LATS11.14570234
56LRRK21.11930887
57PRPF4B1.11663820
58CCNB11.10892921
59MAP2K31.07337514
60TAF11.05574665
61BTK1.03046910
62MARK30.98113887
63CHEK10.97631113
64PIM20.91790380
65MKNK20.91412973
66TRIB30.89040576
67AURKA0.88472448
68PLK30.88192957
69MAPKAPK30.85981915
70CSF1R0.85037868
71CDK60.83831787
72PDGFRA0.81414279
73FGFR40.81001161
74ERBB40.80830934
75ZAK0.76473858
76BRAF0.75415337
77ZAP700.74436724
78ATM0.69287145
79SIK10.68248825
80MAP3K110.67176514
81CLK10.66951245
82KSR20.66037042
83GRK60.65901960
84TYK20.65770804
85JAK30.65522286
86* CDK20.65323911
87STK30.64971371
88BLK0.64185786
89SIK30.63628866
90CDK80.61636630
91CDK180.60514926
92TEC0.59832327
93CDK150.59463645
94PTK60.59332219
95CDK11A0.58128760
96MATK0.56494732
97TTN0.56041510
98BRD40.55629009
99EIF2AK20.54729526
100PAK10.54677891
101CSNK1A1L0.53453608
102CDK140.51999028
103BCKDK0.50745685
104MET0.49666656
105CSNK2A10.49385116
106TESK10.49259494
107RAF10.48767612
108CSNK1G30.48734005
109CDK90.48129284
110IRAK40.46839693
111CDK30.46561747
112CSNK2A20.46468417
113PTK20.45394030
114MAPK110.41872115
115MAP3K20.41755917
116MAP3K30.41572211
117TAOK20.41345756
118CDK10.41143908
119RPS6KA50.40596483
120AKT20.40481675
121LYN0.39920778
122MAPKAPK50.39563575
123BMX0.38460680
124TGFBR20.37955048
125ARAF0.37501347
126MELK0.37252704
127MTOR0.36563211
128ALK0.36524250
129PRKD30.34634765
130ERN10.34425513
131NEK90.33112328
132PAK20.31813124
133SYK0.30687946
134MAPKAPK20.29268543
135ILK0.29091520

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.50595485
2Mismatch repair_Homo sapiens_hsa034304.37197454
3Base excision repair_Homo sapiens_hsa034103.22506289
4Ribosome_Homo sapiens_hsa030103.14004442
5Homologous recombination_Homo sapiens_hsa034403.02594855
6Spliceosome_Homo sapiens_hsa030402.95220182
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93602309
8Nucleotide excision repair_Homo sapiens_hsa034202.77003985
9* Cell cycle_Homo sapiens_hsa041102.66852646
10RNA transport_Homo sapiens_hsa030132.65328383
11One carbon pool by folate_Homo sapiens_hsa006702.55548593
12Proteasome_Homo sapiens_hsa030502.38287742
13RNA polymerase_Homo sapiens_hsa030202.35434121
14Pyrimidine metabolism_Homo sapiens_hsa002402.24438148
15Fanconi anemia pathway_Homo sapiens_hsa034602.18064423
16Non-homologous end-joining_Homo sapiens_hsa034502.08473525
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03894427
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.01172326
19RNA degradation_Homo sapiens_hsa030181.61562433
20* p53 signaling pathway_Homo sapiens_hsa041151.59779006
21Basal transcription factors_Homo sapiens_hsa030221.48368217
22mRNA surveillance pathway_Homo sapiens_hsa030151.39312402
23Pentose phosphate pathway_Homo sapiens_hsa000301.27338781
24Systemic lupus erythematosus_Homo sapiens_hsa053221.25110106
25* Herpes simplex infection_Homo sapiens_hsa051681.12092044
26Antigen processing and presentation_Homo sapiens_hsa046121.10665047
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09060606
28* Epstein-Barr virus infection_Homo sapiens_hsa051691.07574997
29Purine metabolism_Homo sapiens_hsa002301.07548340
30* Viral carcinogenesis_Homo sapiens_hsa052031.01312173
31Primary immunodeficiency_Homo sapiens_hsa053400.99083908
32Folate biosynthesis_Homo sapiens_hsa007900.97508648
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96876440
34* Prostate cancer_Homo sapiens_hsa052150.94399635
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94068059
36Adherens junction_Homo sapiens_hsa045200.93719060
37Pyruvate metabolism_Homo sapiens_hsa006200.90400944
38Biosynthesis of amino acids_Homo sapiens_hsa012300.88410180
39Selenocompound metabolism_Homo sapiens_hsa004500.86517946
40Endometrial cancer_Homo sapiens_hsa052130.85512590
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83152986
42Tyrosine metabolism_Homo sapiens_hsa003500.83048505
43Sulfur relay system_Homo sapiens_hsa041220.82996216
44HTLV-I infection_Homo sapiens_hsa051660.81809245
45Glioma_Homo sapiens_hsa052140.78455752
46* Small cell lung cancer_Homo sapiens_hsa052220.75017268
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.74956787
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.74462142
49Legionellosis_Homo sapiens_hsa051340.74410353
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72672773
51MicroRNAs in cancer_Homo sapiens_hsa052060.72042228
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71751516
53N-Glycan biosynthesis_Homo sapiens_hsa005100.71441950
54Melanoma_Homo sapiens_hsa052180.70880865
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69672788
56Thyroid cancer_Homo sapiens_hsa052160.69490557
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.69382295
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67504050
59Melanogenesis_Homo sapiens_hsa049160.66638678
60Fatty acid elongation_Homo sapiens_hsa000620.65795012
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65023290
62* Measles_Homo sapiens_hsa051620.63499382
63Shigellosis_Homo sapiens_hsa051310.62510244
64Apoptosis_Homo sapiens_hsa042100.61075255
65* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60227697
66Vitamin B6 metabolism_Homo sapiens_hsa007500.58887810
67Galactose metabolism_Homo sapiens_hsa000520.57893455
68Hippo signaling pathway_Homo sapiens_hsa043900.57324295
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.56677458
70* Oocyte meiosis_Homo sapiens_hsa041140.56068733
71Chronic myeloid leukemia_Homo sapiens_hsa052200.55456237
72Carbon metabolism_Homo sapiens_hsa012000.51935070
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51655303
74Proteoglycans in cancer_Homo sapiens_hsa052050.50769977
75* Hepatitis B_Homo sapiens_hsa051610.50570206
76Leishmaniasis_Homo sapiens_hsa051400.50438829
77Acute myeloid leukemia_Homo sapiens_hsa052210.48899591
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48320671
79Glutathione metabolism_Homo sapiens_hsa004800.47371798
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.47366684
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47052951
82Basal cell carcinoma_Homo sapiens_hsa052170.46035888
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45868691
84Fructose and mannose metabolism_Homo sapiens_hsa000510.45809673
85Hematopoietic cell lineage_Homo sapiens_hsa046400.45706374
86Notch signaling pathway_Homo sapiens_hsa043300.45558685
87B cell receptor signaling pathway_Homo sapiens_hsa046620.44980998
88Prion diseases_Homo sapiens_hsa050200.44674998
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43299700
90Influenza A_Homo sapiens_hsa051640.43297227
91Inositol phosphate metabolism_Homo sapiens_hsa005620.43240878
92Renal cell carcinoma_Homo sapiens_hsa052110.43042517
93Colorectal cancer_Homo sapiens_hsa052100.40626969
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40159541
95HIF-1 signaling pathway_Homo sapiens_hsa040660.39790532
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.37901593
97mTOR signaling pathway_Homo sapiens_hsa041500.37685233
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36610409
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35885762
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.35755466
101Insulin signaling pathway_Homo sapiens_hsa049100.35434423
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35312362
103Vibrio cholerae infection_Homo sapiens_hsa051100.35214008
104Other glycan degradation_Homo sapiens_hsa005110.33851332
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.33481023
106Protein export_Homo sapiens_hsa030600.33401153
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32411393
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.31133747
109ErbB signaling pathway_Homo sapiens_hsa040120.30548089
110Viral myocarditis_Homo sapiens_hsa054160.29933937
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29400428
112Alcoholism_Homo sapiens_hsa050340.29356598
113Bladder cancer_Homo sapiens_hsa052190.29141773
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28711739
115Focal adhesion_Homo sapiens_hsa045100.28401426
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28108874
117* Pathways in cancer_Homo sapiens_hsa052000.27344595
118Wnt signaling pathway_Homo sapiens_hsa043100.27208728
119Toxoplasmosis_Homo sapiens_hsa051450.27128635
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26847060
121Non-small cell lung cancer_Homo sapiens_hsa052230.26422340
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24860006
123Lysine degradation_Homo sapiens_hsa003100.24150857
124TGF-beta signaling pathway_Homo sapiens_hsa043500.22912516
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22496107
126Renin-angiotensin system_Homo sapiens_hsa046140.22424165
127Pancreatic cancer_Homo sapiens_hsa052120.21962207
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21956843
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21158462
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21109147
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20910853

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