CDK20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)6.99620986
2multicellular organism reproduction (GO:0032504)6.71763205
3DNA methylation involved in gamete generation (GO:0043046)6.65089714
4male meiosis (GO:0007140)6.20633531
5microtubule severing (GO:0051013)5.63385833
6pyrimidine nucleobase catabolic process (GO:0006208)5.45063975
7axonemal dynein complex assembly (GO:0070286)5.28042507
8reproduction (GO:0000003)5.18942007
9regulation of acrosome reaction (GO:0060046)5.08834856
10epithelial cilium movement (GO:0003351)5.05385295
11female gamete generation (GO:0007292)5.00979000
12regulation of meiosis (GO:0040020)4.99741836
13cilium movement (GO:0003341)4.94974378
14chaperone-mediated protein transport (GO:0072321)4.92595051
15meiotic cell cycle (GO:0051321)4.91235786
16base-excision repair, AP site formation (GO:0006285)4.85167092
17postsynaptic membrane organization (GO:0001941)4.85025884
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.83676577
19binding of sperm to zona pellucida (GO:0007339)4.81470494
20single fertilization (GO:0007338)4.65536751
21sperm-egg recognition (GO:0035036)4.62133372
22regulation of meiosis I (GO:0060631)4.49287626
23protein polyglutamylation (GO:0018095)4.48216381
24fat-soluble vitamin biosynthetic process (GO:0042362)4.46065659
25fertilization (GO:0009566)4.41514715
26nucleobase catabolic process (GO:0046113)4.40408453
27negative regulation of meiosis (GO:0045835)4.40315273
28fusion of sperm to egg plasma membrane (GO:0007342)4.37513617
29cilium or flagellum-dependent cell motility (GO:0001539)4.36269802
30axonal fasciculation (GO:0007413)4.30311294
31regulation of exit from mitosis (GO:0007096)4.23192715
32regulation of cilium movement (GO:0003352)4.17839499
33synaptonemal complex organization (GO:0070193)4.11508767
34protein K6-linked ubiquitination (GO:0085020)4.09884268
35regulation of meiotic cell cycle (GO:0051445)4.08396479
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.07312401
37motile cilium assembly (GO:0044458)4.05419822
38glycerophospholipid catabolic process (GO:0046475)4.04804814
39behavioral response to nicotine (GO:0035095)4.04436632
40citrulline biosynthetic process (GO:0019240)4.03400413
41synaptic vesicle maturation (GO:0016188)4.02104921
42phosphatidylglycerol biosynthetic process (GO:0006655)4.00675192
43neuron cell-cell adhesion (GO:0007158)3.99225789
44synaptonemal complex assembly (GO:0007130)3.96866238
45intraciliary transport (GO:0042073)3.96839654
46presynaptic membrane assembly (GO:0097105)3.93376550
47cell-cell recognition (GO:0009988)3.92778349
48protein deneddylation (GO:0000338)3.91437323
49histone H2A ubiquitination (GO:0033522)3.88616427
50pyrimidine nucleotide catabolic process (GO:0006244)3.86789772
51neuron recognition (GO:0008038)3.86501915
52establishment of mitochondrion localization (GO:0051654)3.84492894
53acrosome reaction (GO:0007340)3.82873561
54mitotic metaphase plate congression (GO:0007080)3.80617179
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.77316109
56regulation of short-term neuronal synaptic plasticity (GO:0048172)3.77100260
57dendritic spine morphogenesis (GO:0060997)3.76618784
58vocalization behavior (GO:0071625)3.74574563
59protein localization to synapse (GO:0035418)3.71089434
60presynaptic membrane organization (GO:0097090)3.71075708
61left/right pattern formation (GO:0060972)3.66266586
62attachment of spindle microtubules to kinetochore (GO:0008608)3.65667591
63histone H2A monoubiquitination (GO:0035518)3.64684479
64nonmotile primary cilium assembly (GO:0035058)3.62599635
65regulation of microtubule-based movement (GO:0060632)3.57157222
66meiotic nuclear division (GO:0007126)3.56930473
67regulation of hypersensitivity (GO:0002883)3.53860394
68oocyte maturation (GO:0001556)3.49654010
69maturation of 5.8S rRNA (GO:0000460)3.49622660
70sperm motility (GO:0030317)3.48823177
71glutamate secretion (GO:0014047)3.46677444
72synaptic vesicle exocytosis (GO:0016079)3.45671120
73positive regulation of meiosis (GO:0045836)3.44844245
74axoneme assembly (GO:0035082)3.44085635
75regulation of synaptic vesicle exocytosis (GO:2000300)3.44082329
76regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.42226244
77protein localization to cilium (GO:0061512)3.40805701
78negative regulation of meiotic cell cycle (GO:0051447)3.40124018
79plasma membrane fusion (GO:0045026)3.38944570
80male meiosis I (GO:0007141)3.37432571
81gamete generation (GO:0007276)3.33339827
82synapse assembly (GO:0007416)3.32628492
83positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.31080046
84transmission of nerve impulse (GO:0019226)3.29758729
85negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.28734017
86negative regulation of DNA-templated transcription, elongation (GO:0032785)3.28734017
87positive regulation of meiotic cell cycle (GO:0051446)3.28635209
88neurotransmitter-gated ion channel clustering (GO:0072578)3.27848131
89retinal ganglion cell axon guidance (GO:0031290)3.25143453
90spermatid development (GO:0007286)3.24869515
91auditory behavior (GO:0031223)3.21939070
92response to misfolded protein (GO:0051788)3.21830447
93cell migration in hindbrain (GO:0021535)3.19498824
94neurofilament cytoskeleton organization (GO:0060052)3.19150252
95female gonad development (GO:0008585)3.18919003
96axon extension (GO:0048675)3.18493524
97positive regulation of T cell apoptotic process (GO:0070234)3.16460858
98oogenesis (GO:0048477)3.16435377
99spermatogenesis (GO:0007283)3.13244382
100eye photoreceptor cell differentiation (GO:0001754)3.12370070
101photoreceptor cell differentiation (GO:0046530)3.12370070
102male gamete generation (GO:0048232)3.12151915
103calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.11791514
104axon extension involved in axon guidance (GO:0048846)3.11634727
105neuron projection extension involved in neuron projection guidance (GO:1902284)3.11634727
106layer formation in cerebral cortex (GO:0021819)3.07386064
107establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.02510144
108mitochondrion transport along microtubule (GO:0047497)3.02510144
109gene silencing by RNA (GO:0031047)3.02015886
110olfactory bulb development (GO:0021772)3.01639001
111positive regulation of synapse assembly (GO:0051965)3.01210319
112meiotic cell cycle process (GO:1903046)3.00360240
113meiosis I (GO:0007127)2.99927782
114metaphase plate congression (GO:0051310)2.98858756
115negative regulation of smooth muscle cell differentiation (GO:0051151)2.98019602
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97833006
117regulation of phospholipid biosynthetic process (GO:0071071)2.96809532
118regulation of synaptic vesicle transport (GO:1902803)2.95832942
119synaptic transmission, glutamatergic (GO:0035249)2.94597945
120regulation of mononuclear cell migration (GO:0071675)2.94492325
121DNA alkylation (GO:0006305)2.94256451
122DNA methylation (GO:0006306)2.94256451
123response to pheromone (GO:0019236)2.94066364
124neurotransmitter secretion (GO:0007269)2.91982869
125cilium morphogenesis (GO:0060271)2.91692402
126negative regulation of execution phase of apoptosis (GO:1900118)2.91642403
127regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.91614828
128regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.91590029
129negative regulation of reproductive process (GO:2000242)2.90256566
130negative regulation of homotypic cell-cell adhesion (GO:0034111)2.87983998
131regulation of synapse structural plasticity (GO:0051823)2.87628438
132protein autoubiquitination (GO:0051865)2.87400788
133regulation of spindle checkpoint (GO:0090231)2.87337992
134ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.86433677
135dendritic spine organization (GO:0097061)2.83779578
136positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.83459218
137mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.83459218
138establishment of chromosome localization (GO:0051303)2.82315560
139immunoglobulin mediated immune response (GO:0016064)2.81391298
140neuromuscular synaptic transmission (GO:0007274)2.79321848
141synaptic vesicle endocytosis (GO:0048488)2.77527201
142locomotory exploration behavior (GO:0035641)2.77444993
143negative regulation of axon guidance (GO:1902668)2.77391888
144peptidyl-arginine modification (GO:0018195)2.77202859
145gamma-aminobutyric acid transport (GO:0015812)2.76240731
146positive regulation of mitochondrial fission (GO:0090141)2.76030014
147neuron projection extension (GO:1990138)2.75582934
148response to auditory stimulus (GO:0010996)2.74837337
149G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73897390
150ganglion development (GO:0061548)2.73480080
151negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.73276569
152positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73102743
153neuronal ion channel clustering (GO:0045161)2.72939147
154microtubule depolymerization (GO:0007019)2.72168193
155pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.71097837
156cell wall macromolecule metabolic process (GO:0044036)2.71092938
157cell wall macromolecule catabolic process (GO:0016998)2.71092938
158cerebral cortex neuron differentiation (GO:0021895)2.69880543
159sphingosine metabolic process (GO:0006670)2.69841831
160ionotropic glutamate receptor signaling pathway (GO:0035235)2.69047936
161microtubule bundle formation (GO:0001578)2.68990250
162positive regulation of Cdc42 GTPase activity (GO:0043089)2.68873198
163cell-cell junction maintenance (GO:0045217)2.67704072
164adult walking behavior (GO:0007628)2.67584612
165mechanosensory behavior (GO:0007638)2.66582606
166exploration behavior (GO:0035640)2.66489035
167hippocampus development (GO:0021766)2.64018544
168cytoskeleton-dependent intracellular transport (GO:0030705)2.63636625
169cilium assembly (GO:0042384)2.63353874
170synapse organization (GO:0050808)2.62972541
171cilium organization (GO:0044782)2.62279217
172establishment of melanosome localization (GO:0032401)2.61905543
173regulation of respiratory system process (GO:0044065)2.61237538
174synaptic vesicle docking involved in exocytosis (GO:0016081)2.60723760
175synaptic transmission, cholinergic (GO:0007271)2.60710272
176negative regulation of axon extension (GO:0030517)2.57624304
177spinal cord association neuron differentiation (GO:0021527)2.56765977
178microtubule-based transport (GO:0010970)2.56515833
179growth hormone secretion (GO:0030252)2.55069795
180glutamate receptor signaling pathway (GO:0007215)2.54765357
181protein insertion into membrane (GO:0051205)2.54462615
182neuron-neuron synaptic transmission (GO:0007270)2.53525738
183cerebellar Purkinje cell differentiation (GO:0021702)2.52645399
184negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.52143408
185camera-type eye morphogenesis (GO:0048593)2.52054347
186regulation of glutamate receptor signaling pathway (GO:1900449)2.51891286
187substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.51825807
188substrate-independent telencephalic tangential migration (GO:0021826)2.51825807
189positive regulation of membrane potential (GO:0045838)2.50245503
190piRNA metabolic process (GO:0034587)10.7313953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.90088407
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.64553194
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.53995100
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.36997833
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.94912214
6KAP1_22055183_ChIP-Seq_ESCs_Mouse2.79449791
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.60376149
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.59996371
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58995948
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.55798677
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.54692831
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50588006
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.25787315
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.19466177
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15561574
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15349777
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14623070
18RNF2_27304074_Chip-Seq_NSC_Mouse2.12088770
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.11570553
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06294014
21MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.05061609
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00452071
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94087719
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.85841486
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80399033
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80399033
27ZNF274_21170338_ChIP-Seq_K562_Hela1.79084487
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78121904
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70691827
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69984545
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.65969312
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65704302
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.56709929
34VDR_22108803_ChIP-Seq_LS180_Human1.55814370
35STAT1_17558387_ChIP-Seq_HELA_Human1.55508583
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.52506987
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52177779
38* GATA3_21867929_ChIP-Seq_TH1_Mouse1.51939403
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49404207
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48045910
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46013574
42CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43800750
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43237219
44* RARB_27405468_Chip-Seq_BRAIN_Mouse1.42588299
45AR_21909140_ChIP-Seq_LNCAP_Human1.40998277
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40046613
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39372709
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39214029
49IGF1R_20145208_ChIP-Seq_DFB_Human1.38314354
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.37385650
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37135755
52DROSHA_22980978_ChIP-Seq_HELA_Human1.35821721
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.34150931
54GBX2_23144817_ChIP-Seq_PC3_Human1.34149038
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33705462
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33408940
57REST_21632747_ChIP-Seq_MESCs_Mouse1.31411310
58OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29567233
59CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.29132170
60KDM2B_26808549_Chip-Seq_REH_Human1.28197595
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27220625
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25272887
63SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25145189
64* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.24431120
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22944448
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21821346
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16172796
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15946975
69SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15425742
70TAL1_26923725_Chip-Seq_HPCs_Mouse1.15117266
71* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13288376
72LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12283810
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11505407
74CTCF_27219007_Chip-Seq_Bcells_Human1.11106941
75LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10574456
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.09491404
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.09289412
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09004508
79* NANOG_20526341_ChIP-Seq_ESCs_Human1.08991587
80TBL1_22424771_ChIP-Seq_293T_Human1.08706542
81ETV1_20927104_ChIP-Seq_GIST48_Human1.08591956
82NFYA_21822215_ChIP-Seq_K562_Human1.08012092
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07463447
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.06698224
85* TET1_21490601_ChIP-Seq_MESCs_Mouse1.06509757
86PHF8_20622853_ChIP-Seq_HELA_Human1.06385446
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05962810
88* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05799905
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.05539898
90AR_21572438_ChIP-Seq_LNCaP_Human1.05508011
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05472120
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05255245
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04280221
94CBX2_22325352_ChIP-Seq_293T-Rex_Human1.04065155
95OCT4_20526341_ChIP-Seq_ESCs_Human1.03974532
96BP1_19119308_ChIP-ChIP_Hs578T_Human1.03829032
97FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03691966
98AR_25329375_ChIP-Seq_VCAP_Human1.03105965
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.02551517
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02261282
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01806635
102* FLI1_21867929_ChIP-Seq_TH2_Mouse1.00429343
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99696442
104GATA3_21867929_ChIP-Seq_CD8_Mouse0.99596564
105* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.98910917
106FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98626023
107REST_18959480_ChIP-ChIP_MESCs_Mouse0.97950852
108ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97113168
109ESET_19884257_ChIP-Seq_ESCs_Mouse0.96909267
110TAF15_26573619_Chip-Seq_HEK293_Human0.96804139
111SMAD4_21799915_ChIP-Seq_A2780_Human0.96735033
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96430577
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96226910
114STAT3_18555785_Chip-Seq_ESCs_Mouse0.95296093
115STAT1_20625510_ChIP-Seq_HELA_Human0.94826913
116NANOG_19829295_ChIP-Seq_ESCs_Human0.94682512
117SOX2_19829295_ChIP-Seq_ESCs_Human0.94682512
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94482158
119RBPJ_21746931_ChIP-Seq_IB4_Human0.94093652
120RUNX1_26923725_Chip-Seq_HPCs_Mouse0.94062198
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94036890
122FUS_26573619_Chip-Seq_HEK293_Human0.93672904
123NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93481421
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93336384
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93131813
126ERG_20517297_ChIP-Seq_VCAP_Human0.92510277
127IRF1_19129219_ChIP-ChIP_H3396_Human0.92420867
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91280029
129NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90743612
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90495963
131P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90448495
132GABP_17652178_ChIP-ChIP_JURKAT_Human0.89662134
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89524194
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89441604
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89300941
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88367121
137KLF4_18555785_Chip-Seq_ESCs_Mouse0.88268935
138HNFA_21074721_ChIP-Seq_CACO-2_Human0.88006222
139SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87422091
140GF1B_26923725_Chip-Seq_HPCs_Mouse0.87371780
141P300_19829295_ChIP-Seq_ESCs_Human0.87213976
142* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87212527
143CTCF_18555785_Chip-Seq_ESCs_Mouse0.87046210
144GF1_26923725_Chip-Seq_HPCs_Mouse0.85909542
145STAT3_23295773_ChIP-Seq_U87_Human0.85834698
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85765801
147POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85765801
148GATA6_21074721_ChIP-Seq_CACO-2_Human0.85636487
149FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85341052
150RING1B_27294783_Chip-Seq_NPCs_Mouse0.84695707
151AR_19668381_ChIP-Seq_PC3_Human0.82321738
152SOX2_21211035_ChIP-Seq_LN229_Gbm0.82163362
153PIAS1_25552417_ChIP-Seq_VCAP_Human0.81377154
154TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80808032
155DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79737520
156* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.79163511
157POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79077063
158YY1_21170310_ChIP-Seq_MESCs_Mouse0.78489233
159NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78175209
160IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.77852904
161CBP_20019798_ChIP-Seq_JUKART_Human0.77852904
162SOX3_22085726_ChIP-Seq_NPCs_Mouse0.77291473
163TP53_22573176_ChIP-Seq_HFKS_Human0.77193990
164ZFP281_18757296_ChIP-ChIP_E14_Mouse0.76752354
165* RUNX2_22187159_ChIP-Seq_PCA_Human0.76513130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.73830484
2MP0002653_abnormal_ependyma_morphology4.42520572
3MP0005410_abnormal_fertilization4.17499468
4MP0003718_maternal_effect4.15758923
5MP0003646_muscle_fatigue4.02819648
6MP0005451_abnormal_body_composition4.00094976
7MP0001929_abnormal_gametogenesis3.13620880
8MP0008260_abnormal_autophagy2.91329362
9MP0003122_maternal_imprinting2.86314791
10MP0001529_abnormal_vocalization2.67492493
11MP0005646_abnormal_pituitary_gland2.59515947
12MP0005394_taste/olfaction_phenotype2.54080356
13MP0005499_abnormal_olfactory_system2.54080356
14MP0006276_abnormal_autonomic_nervous2.44245851
15MP0002102_abnormal_ear_morphology2.43878729
16MP0002210_abnormal_sex_determination2.40369513
17MP0008789_abnormal_olfactory_epithelium2.33648925
18MP0009840_abnormal_foam_cell2.28442608
19MP0003698_abnormal_male_reproductive2.28417989
20MP0003699_abnormal_female_reproductive2.24293268
21MP0000653_abnormal_sex_gland2.23985581
22MP0001905_abnormal_dopamine_level2.22775337
23MP0003329_amyloid_beta_deposits2.19680704
24MP0001119_abnormal_female_reproductive2.10358681
25MP0002822_catalepsy2.09097716
26MP0002161_abnormal_fertility/fecundity2.07349354
27MP0010094_abnormal_chromosome_stability2.00354065
28MP0000604_amyloidosis1.86992763
29MP0009745_abnormal_behavioral_response1.85162458
30MP0002064_seizures1.80085100
31MP0001486_abnormal_startle_reflex1.78824699
32MP0004133_heterotaxia1.76016783
33MP0005257_abnormal_intraocular_pressure1.74711427
34MP0002736_abnormal_nociception_after1.73165649
35MP0001145_abnormal_male_reproductive1.72628474
36MP0004270_analgesia1.71015207
37MP0000955_abnormal_spinal_cord1.70844707
38MP0002557_abnormal_social/conspecific_i1.70216087
39MP0006292_abnormal_olfactory_placode1.68790506
40MP0002734_abnormal_mechanical_nocicepti1.68499245
41MP0005423_abnormal_somatic_nervous1.68117791
42MP0000566_synostosis1.67401090
43MP0005395_other_phenotype1.66284461
44MP0006072_abnormal_retinal_apoptosis1.63714451
45MP0002735_abnormal_chemical_nociception1.63582001
46MP0002249_abnormal_larynx_morphology1.62440568
47MP0003123_paternal_imprinting1.61947261
48MP0003656_abnormal_erythrocyte_physiolo1.55868714
49MP0004811_abnormal_neuron_physiology1.52799336
50MP0003950_abnormal_plasma_membrane1.50771135
51MP0005551_abnormal_eye_electrophysiolog1.48463102
52MP0002184_abnormal_innervation1.46432416
53MP0003787_abnormal_imprinting1.43727204
54MP0005408_hypopigmentation1.42492947
55MP0010386_abnormal_urinary_bladder1.41486991
56MP0001984_abnormal_olfaction1.40917918
57MP0001502_abnormal_circadian_rhythm1.40809426
58MP0002638_abnormal_pupillary_reflex1.36245012
59MP0000579_abnormal_nail_morphology1.30535453
60MP0009379_abnormal_foot_pigmentation1.28417723
61MP0004859_abnormal_synaptic_plasticity1.24232728
62MP0005645_abnormal_hypothalamus_physiol1.22640904
63MP0002152_abnormal_brain_morphology1.22540764
64MP0001968_abnormal_touch/_nociception1.21824785
65MP0005058_abnormal_lysosome_morphology1.17858042
66MP0000049_abnormal_middle_ear1.17762892
67MP0003111_abnormal_nucleus_morphology1.17632599
68MP0001188_hyperpigmentation1.17353884
69MP0000465_gastrointestinal_hemorrhage1.16555921
70MP0001919_abnormal_reproductive_system1.14359078
71MP0003011_delayed_dark_adaptation1.14342118
72MP0003690_abnormal_glial_cell1.10658124
73MP0003136_yellow_coat_color1.10517448
74MP0003861_abnormal_nervous_system1.10495376
75MP0003879_abnormal_hair_cell1.09999548
76MP0005389_reproductive_system_phenotype1.04193477
77MP0002909_abnormal_adrenal_gland1.03184168
78MP0010030_abnormal_orbit_morphology1.02895587
79MP0003632_abnormal_nervous_system1.02566648
80MP0002066_abnormal_motor_capabilities/c1.01889576
81MP0005377_hearing/vestibular/ear_phenot1.01727769
82MP0003878_abnormal_ear_physiology1.01727769
83MP0001963_abnormal_hearing_physiology1.00711730
84MP0001501_abnormal_sleep_pattern1.00636851
85MP0003942_abnormal_urinary_system0.97927222
86MP0002295_abnormal_pulmonary_circulatio0.97735159
87MP0003693_abnormal_embryo_hatching0.97405557
88MP0003077_abnormal_cell_cycle0.96166705
89MP0003315_abnormal_perineum_morphology0.94821842
90MP0001970_abnormal_pain_threshold0.93603085
91MP0003938_abnormal_ear_development0.93480654
92MP0001986_abnormal_taste_sensitivity0.91319881
93MP0002229_neurodegeneration0.89763813
94MP0002733_abnormal_thermal_nociception0.89155289
95MP0002572_abnormal_emotion/affect_behav0.89031425
96MP0000639_abnormal_adrenal_gland0.88997420
97MP0005253_abnormal_eye_physiology0.88123669
98MP0005248_abnormal_Harderian_gland0.87880488
99MP0005310_abnormal_salivary_gland0.86719096
100MP0002751_abnormal_autonomic_nervous0.86346938
101MP0002234_abnormal_pharynx_morphology0.85915874
102MP0001293_anophthalmia0.85508410
103MP0003119_abnormal_digestive_system0.85254775
104MP0008569_lethality_at_weaning0.84338236
105MP0003121_genomic_imprinting0.82741096
106MP0002752_abnormal_somatic_nervous0.82697278
107MP0005195_abnormal_posterior_eye0.82647162
108MP0004142_abnormal_muscle_tone0.82451860
109MP0001346_abnormal_lacrimal_gland0.81809327
110MP0006035_abnormal_mitochondrial_morpho0.80761713
111MP0002938_white_spotting0.80013408
112MP0002233_abnormal_nose_morphology0.79664079
113MP0000534_abnormal_ureter_morphology0.79313874
114MP0002069_abnormal_eating/drinking_beha0.78688564
115MP0008995_early_reproductive_senescence0.78202173
116MP0000462_abnormal_digestive_system0.77684786
117MP0004043_abnormal_pH_regulation0.76757264
118MP0003880_abnormal_central_pattern0.76665921
119MP0003634_abnormal_glial_cell0.76405775
120MP0001324_abnormal_eye_pigmentation0.75518547
121MP0005391_vision/eye_phenotype0.75354244
122MP0001440_abnormal_grooming_behavior0.74676066
123MP0002160_abnormal_reproductive_system0.74431747
124MP0009046_muscle_twitch0.73944478
125MP0004885_abnormal_endolymph0.72469277
126MP0003633_abnormal_nervous_system0.71521402
127MP0003635_abnormal_synaptic_transmissio0.70879728
128MP0000343_altered_response_to0.70268760
129MP0002063_abnormal_learning/memory/cond0.69997708
130MP0001299_abnormal_eye_distance/0.69907612
131MP0002272_abnormal_nervous_system0.69793898
132MP0004742_abnormal_vestibular_system0.69559600
133MP0000778_abnormal_nervous_system0.69175656
134MP0002067_abnormal_sensory_capabilities0.68367327
135MP0000631_abnormal_neuroendocrine_gland0.68250438
136MP0003937_abnormal_limbs/digits/tail_de0.67203851
137MP0003172_abnormal_lysosome_physiology0.67086477
138MP0005171_absent_coat_pigmentation0.66644995
139MP0002882_abnormal_neuron_morphology0.66263457
140MP0008058_abnormal_DNA_repair0.66003240
141MP0002177_abnormal_outer_ear0.63943564
142MP0001485_abnormal_pinna_reflex0.63231728
143MP0005197_abnormal_uvea_morphology0.62812578
144MP0004924_abnormal_behavior0.62717697
145MP0005386_behavior/neurological_phenoty0.62717697
146MP0000026_abnormal_inner_ear0.61930328
147MP0000358_abnormal_cell_content/0.60579140
148MP0001851_eye_inflammation0.59852217

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.84716253
2Abnormal respiratory motile cilium physiology (HP:0012261)6.04191603
3Male infertility (HP:0003251)5.47687052
4Infertility (HP:0000789)5.29993219
5Abnormal ciliary motility (HP:0012262)4.92571405
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.83421914
7Absent/shortened dynein arms (HP:0200106)4.83421914
8Chronic bronchitis (HP:0004469)4.48142758
9Rhinitis (HP:0012384)4.47000875
10Abnormal respiratory epithelium morphology (HP:0012253)4.11842868
11Abnormal respiratory motile cilium morphology (HP:0005938)4.11842868
12Neurofibrillary tangles (HP:0002185)4.05591254
13Gait imbalance (HP:0002141)3.37078810
14Premature ovarian failure (HP:0008209)3.32957175
15Mutism (HP:0002300)3.29036396
16Medial flaring of the eyebrow (HP:0010747)3.24757859
17Bronchiectasis (HP:0002110)3.24524745
18Congenital primary aphakia (HP:0007707)3.17663290
19Supernumerary spleens (HP:0009799)2.95844050
20Pancreatic fibrosis (HP:0100732)2.95058984
21Type II lissencephaly (HP:0007260)2.93004392
22Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.89985966
23Flat capital femoral epiphysis (HP:0003370)2.83501901
24Nephrogenic diabetes insipidus (HP:0009806)2.82713222
25Occipital encephalocele (HP:0002085)2.81296397
26Breast hypoplasia (HP:0003187)2.80564937
27Poor coordination (HP:0002370)2.75078192
28Molar tooth sign on MRI (HP:0002419)2.68826134
29Abnormality of midbrain morphology (HP:0002418)2.68826134
30Cerebral inclusion bodies (HP:0100314)2.63764076
31Polyphagia (HP:0002591)2.63480844
32Nephronophthisis (HP:0000090)2.60437711
33Genital tract atresia (HP:0001827)2.59974467
34Epileptic encephalopathy (HP:0200134)2.57348258
35Personality changes (HP:0000751)2.55643661
36Retinal dysplasia (HP:0007973)2.55490844
37Lissencephaly (HP:0001339)2.55440343
38Secondary amenorrhea (HP:0000869)2.54093801
39Limb dystonia (HP:0002451)2.53928488
40Adrenal hypoplasia (HP:0000835)2.53467087
41Abnormality of the fovea (HP:0000493)2.52050390
42Abnormal eating behavior (HP:0100738)2.51529768
43Vaginal atresia (HP:0000148)2.49927983
44Impaired vibration sensation in the lower limbs (HP:0002166)2.48989891
45Aplasia/Hypoplasia of the brainstem (HP:0007362)2.48168415
46Hypoplasia of the brainstem (HP:0002365)2.48168415
47Anterior segment dysgenesis (HP:0007700)2.44808494
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.44521601
49Disinhibition (HP:0000734)2.42617371
50Hypoplastic pelvis (HP:0008839)2.41765493
51Tubulointerstitial nephritis (HP:0001970)2.40498791
52Focal motor seizures (HP:0011153)2.40365806
53Aplasia/Hypoplasia of the lens (HP:0008063)2.40319094
54Cortical dysplasia (HP:0002539)2.37228388
55Abnormality of lateral ventricle (HP:0030047)2.36000404
56Abnormality of the corticospinal tract (HP:0002492)2.33405145
57Specific learning disability (HP:0001328)2.32918633
58Ankle clonus (HP:0011448)2.32282774
59Oligodactyly (hands) (HP:0001180)2.32258678
60Nasal polyposis (HP:0100582)2.31230218
61Birth length less than 3rd percentile (HP:0003561)2.26316740
62Delusions (HP:0000746)2.25299746
63Neuronal loss in central nervous system (HP:0002529)2.25080185
64Cerebellar dysplasia (HP:0007033)2.24520177
65Hypoplasia of the fovea (HP:0007750)2.24010167
66Aplasia/Hypoplasia of the fovea (HP:0008060)2.24010167
67Pancreatic cysts (HP:0001737)2.23537149
68True hermaphroditism (HP:0010459)2.22725921
69Pachygyria (HP:0001302)2.22508245
70Degeneration of the lateral corticospinal tracts (HP:0002314)2.22345919
71Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.22345919
72Sleep apnea (HP:0010535)2.21849628
73Bifid tongue (HP:0010297)2.21397125
74Postaxial foot polydactyly (HP:0001830)2.20735430
75Drooling (HP:0002307)2.19907367
76Agitation (HP:0000713)2.19124220
77Facial hemangioma (HP:0000329)2.18748775
78Tubular atrophy (HP:0000092)2.18529235
79Spastic gait (HP:0002064)2.17468391
80Hypsarrhythmia (HP:0002521)2.17463964
81Progressive cerebellar ataxia (HP:0002073)2.17255247
82Postaxial hand polydactyly (HP:0001162)2.17250593
83Abnormality of liposaccharide metabolism (HP:0010968)2.16876565
84Abnormality of glycosphingolipid metabolism (HP:0004343)2.16876565
85Abnormality of glycolipid metabolism (HP:0010969)2.16876565
86Failure to thrive in infancy (HP:0001531)2.14691909
87Epileptiform EEG discharges (HP:0011182)2.14103827
88EEG with generalized epileptiform discharges (HP:0011198)2.13614383
89Focal seizures (HP:0007359)2.13284988
90Prostate neoplasm (HP:0100787)2.11987644
91Double outlet right ventricle (HP:0001719)2.11926842
92Congenital malformation of the right heart (HP:0011723)2.11926842
93Chronic hepatic failure (HP:0100626)2.11390653
94Aplasia/Hypoplasia of the breasts (HP:0010311)2.08342839
95Broad foot (HP:0001769)2.06704196
96Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.05633473
97Anencephaly (HP:0002323)2.05323793
98Cystic liver disease (HP:0006706)2.04637017
99Oligodactyly (HP:0012165)2.04205301
100Spastic tetraplegia (HP:0002510)2.03095892
101Supranuclear gaze palsy (HP:0000605)2.02266485
102Hepatoblastoma (HP:0002884)2.01866082
103Patellar aplasia (HP:0006443)2.01508733
104Severe visual impairment (HP:0001141)1.99979119
105Abolished electroretinogram (ERG) (HP:0000550)1.99194299
106Abnormality of the renal medulla (HP:0100957)1.97719525
107Decreased testicular size (HP:0008734)1.96851180
108Type 2 muscle fiber atrophy (HP:0003554)1.96566464
109Abnormality of macular pigmentation (HP:0008002)1.96563324
110Urinary urgency (HP:0000012)1.96108990
111Excessive salivation (HP:0003781)1.96075002
112Atelectasis (HP:0100750)1.95354290
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.94624077
114Absent epiphyses (HP:0010577)1.94624077
115Abnormal gallbladder physiology (HP:0012438)1.93792294
116Cholecystitis (HP:0001082)1.93792294
117Abnormality of the aortic arch (HP:0012303)1.93397086
118Hand muscle atrophy (HP:0009130)1.92565919
119Abnormality of the lower motor neuron (HP:0002366)1.90991090
120Abnormality of the labia minora (HP:0012880)1.89917234
121Tubulointerstitial fibrosis (HP:0005576)1.89605128
122Increased serum pyruvate (HP:0003542)1.89275797
123Abnormality of glycolysis (HP:0004366)1.89275797
124Breast aplasia (HP:0100783)1.88298851
125Left ventricular hypertrophy (HP:0001712)1.88264290
126Hypergonadotropic hypogonadism (HP:0000815)1.87975398
127Amniotic constriction ring (HP:0009775)1.87359082
128Abnormality of placental membranes (HP:0011409)1.87359082
129Impulsivity (HP:0100710)1.86584846
130Absent speech (HP:0001344)1.85930232
131Arterial tortuosity (HP:0005116)1.85206422
132Myokymia (HP:0002411)1.83425069
133Amblyopia (HP:0000646)1.82892217
134Labial hypoplasia (HP:0000066)1.79893108
135Urinary bladder sphincter dysfunction (HP:0002839)1.79569455
136Intestinal atresia (HP:0011100)1.79409419
137Hypoplasia of the corpus callosum (HP:0002079)1.78927667
138Vacuolated lymphocytes (HP:0001922)1.78492850
139Anomalous pulmonary venous return (HP:0010772)1.78380776
140Abnormality of the femoral head (HP:0003368)1.77790545
141Cerebral hypomyelination (HP:0006808)1.77540284
142Aplasia/Hypoplasia of the patella (HP:0006498)1.76598554
143Bony spicule pigmentary retinopathy (HP:0007737)1.76456993
144Bronchitis (HP:0012387)1.76194677
145Acute necrotizing encephalopathy (HP:0006965)1.76100671
146Hyperventilation (HP:0002883)1.75904894
147Abnormal spermatogenesis (HP:0008669)1.75744809
148Chorioretinal atrophy (HP:0000533)1.75652605
149Renal dysplasia (HP:0000110)1.75286356
150Micropenis (HP:0000054)1.74748046
151Abnormality of the axillary hair (HP:0100134)1.74476723
152Abnormality of secondary sexual hair (HP:0009888)1.74476723
153Narrow forehead (HP:0000341)1.73688418
154Sclerocornea (HP:0000647)1.73258907
155Esotropia (HP:0000565)1.72947037
156Irregular epiphyses (HP:0010582)1.72571587
157Retinitis pigmentosa (HP:0000510)1.72425986
158Abnormality of the epiphysis of the femoral head (HP:0010574)1.71947241
159Morphological abnormality of the pyramidal tract (HP:0002062)1.70925634
160Aplasia/Hypoplasia affecting the retina (HP:0008061)1.70925454
161Short femoral neck (HP:0100864)1.70218581
162Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70214021
163Atonic seizures (HP:0010819)1.69311051
164Buphthalmos (HP:0000557)1.68680038
165Aplasia/Hypoplasia of the macula (HP:0008059)1.68016700
166Long foot (HP:0001833)1.67716803
167Broad-based gait (HP:0002136)1.64851004
168Poor suck (HP:0002033)1.64186993
169Preaxial hand polydactyly (HP:0001177)1.63599428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.10109650
2ARAF3.72524401
3BRAF3.57944313
4MUSK3.01218192
5ERBB42.99894248
6MAP3K92.96593110
7KSR22.68274438
8DYRK22.64470794
9SIK22.61924680
10WNK32.57161871
11PRKD32.52215336
12MAPKAPK52.42138978
13TTK2.40670674
14NTRK32.32023330
15MOS2.22700456
16LATS22.17875279
17TAOK32.16618081
18EPHA32.16314551
19ACVR1B2.15177066
20MAP4K22.13214822
21BCR2.03574255
22EEF2K2.00094145
23CDK81.95022693
24MAPK131.94345383
25BMPR1B1.85217103
26LATS11.78739619
27PLK41.74457609
28MAP3K131.73770530
29STK161.72862642
30EPHB21.71210991
31BCKDK1.69614300
32MAPK151.65929503
33RAF11.60514499
34BUB11.53227202
35NTRK21.52515528
36CASK1.49595105
37DAPK21.48561108
38CAMKK11.43027314
39STK38L1.42425162
40PRKCG1.40902234
41MAPKAPK31.40423101
42BMPR21.29975408
43CHEK21.29680853
44PAK31.28191682
45CAMKK21.24736663
46PAK61.24656405
47AURKA1.23162369
48UHMK11.20843684
49TAOK11.20540956
50PDK31.19799545
51PDK41.19799545
52PNCK1.16206604
53DYRK31.15226703
54CSNK1G31.12790082
55MAP2K41.11478615
56CSNK1G21.09547381
57CDK51.07637883
58MAP3K111.06940701
59LIMK11.01304827
60MELK0.98287977
61ABL20.97755210
62DYRK1B0.94658187
63KSR10.93689015
64FGR0.92480560
65PLK10.89975124
66MARK10.88843773
67PHKG20.86638084
68PHKG10.86638084
69CSNK1G10.85515162
70GRK70.85270223
71STK30.84033813
72MAP3K40.82726644
73PDK20.82567445
74CDC70.82556974
75TRPM70.82389291
76PRKCZ0.82105329
77NME10.81996777
78TRIM280.80414311
79MAP2K70.79636037
80KIT0.79628906
81CSNK1A1L0.77409995
82PINK10.75301302
83SRPK10.75222433
84WNK40.72947112
85ADRBK20.72520316
86CAMK10.70559783
87EPHA40.69531342
88PLK20.69424682
89VRK10.69176978
90PRKCE0.68801355
91ERBB30.68573695
92STK110.67956568
93BRSK10.67198755
94TNIK0.66490714
95SGK2230.65193801
96SGK4940.65193801
97FGFR20.64685527
98TYRO30.64285914
99NEK20.59406371
100GRK10.56180121
101CAMK2A0.56174149
102MARK20.55878636
103CAMK40.55600170
104INSRR0.54932515
105CDK180.53755100
106CAMK2B0.53464072
107FES0.52582514
108CDK150.52110543
109STK100.50589677
110PRKACA0.49073248
111EIF2AK10.48778575
112ERBB20.48671828
113ICK0.47812456
114CAMK1G0.47228686
115PIM20.46762024
116STK380.45292989
117CSNK1A10.45194015
118TESK10.43025053
119MAP3K80.42534982
120RPS6KA40.41588698
121IRAK20.40641446
122CDK11A0.39453378
123CSNK1E0.39239209
124CDK90.38165188
125CDK140.36879407
126PAK10.35889881
127PRKD20.35375416
128ADRBK10.35332352
129PKN10.34775731
130CAMK2G0.34245806
131OXSR10.33522718
132AKT30.33248112
133PLK30.32627922
134RPS6KA50.32061242
135STK390.31322098
136CDK190.31320616
137RPS6KA20.30595221
138CDK30.30177172
139PRKG10.30012053
140MINK10.28517156
141MAPK120.28078784
142NTRK10.27322472
143PBK0.27163750
144WEE10.27068951
145SIK30.26799435
146PRKAA10.26597159
147EPHB10.25818680
148SGK20.25379873
149STK240.25364374
150DYRK1A0.25321564
151CCNB10.24609065

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.15394496
2Basal transcription factors_Homo sapiens_hsa030223.16463774
3Ether lipid metabolism_Homo sapiens_hsa005653.04515043
4Steroid biosynthesis_Homo sapiens_hsa001003.03443692
5Other glycan degradation_Homo sapiens_hsa005113.03113295
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.62849331
7Linoleic acid metabolism_Homo sapiens_hsa005912.62101754
8Ovarian steroidogenesis_Homo sapiens_hsa049132.52775272
9Circadian rhythm_Homo sapiens_hsa047102.51437265
10Cell cycle_Homo sapiens_hsa041102.46192751
11RNA degradation_Homo sapiens_hsa030182.36253020
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.26197452
13Oxidative phosphorylation_Homo sapiens_hsa001902.26057822
14Sphingolipid metabolism_Homo sapiens_hsa006002.20905195
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.10207202
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.07452927
17Oocyte meiosis_Homo sapiens_hsa041142.03039516
18Morphine addiction_Homo sapiens_hsa050321.97887412
19Homologous recombination_Homo sapiens_hsa034401.94727455
20Parkinsons disease_Homo sapiens_hsa050121.92224698
21DNA replication_Homo sapiens_hsa030301.87524341
22Dopaminergic synapse_Homo sapiens_hsa047281.75436060
23Mismatch repair_Homo sapiens_hsa034301.73537985
24Protein export_Homo sapiens_hsa030601.70861302
25Circadian entrainment_Homo sapiens_hsa047131.70205617
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.68154535
27Axon guidance_Homo sapiens_hsa043601.66777568
28Base excision repair_Homo sapiens_hsa034101.62809030
29Cardiac muscle contraction_Homo sapiens_hsa042601.58082093
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56811539
31RNA polymerase_Homo sapiens_hsa030201.56769514
32Amphetamine addiction_Homo sapiens_hsa050311.55808187
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53091066
34Fanconi anemia pathway_Homo sapiens_hsa034601.47623451
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44826046
36Butanoate metabolism_Homo sapiens_hsa006501.44256335
37Non-homologous end-joining_Homo sapiens_hsa034501.42276525
38Alzheimers disease_Homo sapiens_hsa050101.40156888
39Lysosome_Homo sapiens_hsa041421.38007829
40Cholinergic synapse_Homo sapiens_hsa047251.37454721
41Taste transduction_Homo sapiens_hsa047421.33909104
42Phototransduction_Homo sapiens_hsa047441.26073278
43Fatty acid biosynthesis_Homo sapiens_hsa000611.24425134
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.19988038
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19147222
46Purine metabolism_Homo sapiens_hsa002301.07028260
47Nucleotide excision repair_Homo sapiens_hsa034201.06497267
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00554295
49Pyruvate metabolism_Homo sapiens_hsa006200.98482317
50GnRH signaling pathway_Homo sapiens_hsa049120.96641699
51Dorso-ventral axis formation_Homo sapiens_hsa043200.95585740
52Gap junction_Homo sapiens_hsa045400.94761391
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94525933
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93277874
55Folate biosynthesis_Homo sapiens_hsa007900.92701988
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92473901
57Nicotine addiction_Homo sapiens_hsa050330.91568780
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90631972
59Basal cell carcinoma_Homo sapiens_hsa052170.89814695
60Phagosome_Homo sapiens_hsa041450.89587105
61Synaptic vesicle cycle_Homo sapiens_hsa047210.89453282
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88609900
63Arachidonic acid metabolism_Homo sapiens_hsa005900.88105287
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87990722
65Sulfur relay system_Homo sapiens_hsa041220.87141633
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85697634
67Serotonergic synapse_Homo sapiens_hsa047260.84931219
68Regulation of autophagy_Homo sapiens_hsa041400.84828823
69Collecting duct acid secretion_Homo sapiens_hsa049660.84295595
70Glutamatergic synapse_Homo sapiens_hsa047240.82568528
71Pyrimidine metabolism_Homo sapiens_hsa002400.82212573
72Melanogenesis_Homo sapiens_hsa049160.81897329
73RNA transport_Homo sapiens_hsa030130.81243507
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80902963
75beta-Alanine metabolism_Homo sapiens_hsa004100.79655279
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78677838
77Pancreatic cancer_Homo sapiens_hsa052120.78510070
78Salivary secretion_Homo sapiens_hsa049700.77532656
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77076457
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76633868
81Fatty acid elongation_Homo sapiens_hsa000620.75912723
82Olfactory transduction_Homo sapiens_hsa047400.73840544
83Gastric acid secretion_Homo sapiens_hsa049710.71166358
84Arginine and proline metabolism_Homo sapiens_hsa003300.67400524
85Rheumatoid arthritis_Homo sapiens_hsa053230.66993419
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66849995
87Hippo signaling pathway_Homo sapiens_hsa043900.66026406
88Oxytocin signaling pathway_Homo sapiens_hsa049210.65625381
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65599156
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64359977
91cAMP signaling pathway_Homo sapiens_hsa040240.64231894
92Insulin secretion_Homo sapiens_hsa049110.63739225
93Long-term depression_Homo sapiens_hsa047300.62480300
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61710603
95Notch signaling pathway_Homo sapiens_hsa043300.61180354
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60370029
97Ribosome_Homo sapiens_hsa030100.60088986
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59391729
99Huntingtons disease_Homo sapiens_hsa050160.55796645
100Glycerolipid metabolism_Homo sapiens_hsa005610.55327097
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54196717
102Long-term potentiation_Homo sapiens_hsa047200.54098285
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.53201609
104Calcium signaling pathway_Homo sapiens_hsa040200.51135543
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49912790
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49230439
107Phenylalanine metabolism_Homo sapiens_hsa003600.49092994
108Choline metabolism in cancer_Homo sapiens_hsa052310.48722399
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48700685
110Propanoate metabolism_Homo sapiens_hsa006400.48661965
111Alcoholism_Homo sapiens_hsa050340.48437783
112Fructose and mannose metabolism_Homo sapiens_hsa000510.47854713
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47677372
114Biosynthesis of amino acids_Homo sapiens_hsa012300.47372952
115Cocaine addiction_Homo sapiens_hsa050300.45445295
116Metabolic pathways_Homo sapiens_hsa011000.45061517
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43546214
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.42987346
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42891606
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40478804
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40013763
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38968751
123GABAergic synapse_Homo sapiens_hsa047270.38831683
124Colorectal cancer_Homo sapiens_hsa052100.38805794
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38555802
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38525596
127Pentose phosphate pathway_Homo sapiens_hsa000300.38458684
128Complement and coagulation cascades_Homo sapiens_hsa046100.37614490
129Hedgehog signaling pathway_Homo sapiens_hsa043400.37532297
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37075630
131Thyroid hormone synthesis_Homo sapiens_hsa049180.36014418
132TGF-beta signaling pathway_Homo sapiens_hsa043500.35830509
133Wnt signaling pathway_Homo sapiens_hsa043100.35806400
134Fatty acid metabolism_Homo sapiens_hsa012120.35303788
135Chemical carcinogenesis_Homo sapiens_hsa052040.33965071
136Ras signaling pathway_Homo sapiens_hsa040140.33302224
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33252918
138Bile secretion_Homo sapiens_hsa049760.33073730
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32768378
140Malaria_Homo sapiens_hsa051440.32210334
141Glucagon signaling pathway_Homo sapiens_hsa049220.32170947
142Histidine metabolism_Homo sapiens_hsa003400.30480189
143Vibrio cholerae infection_Homo sapiens_hsa051100.30177483
144Inositol phosphate metabolism_Homo sapiens_hsa005620.30138902
145Shigellosis_Homo sapiens_hsa051310.29817710
146Glutathione metabolism_Homo sapiens_hsa004800.29172358
147p53 signaling pathway_Homo sapiens_hsa041150.29033552
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25990283
149Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25673300
150Peroxisome_Homo sapiens_hsa041460.22365077
151Staphylococcus aureus infection_Homo sapiens_hsa051500.21837157
152mRNA surveillance pathway_Homo sapiens_hsa030150.21567478
153Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20893161

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