CDK2AP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)5.05152230
2cytidine catabolic process (GO:0006216)5.05152230
3cytidine deamination (GO:0009972)5.05152230
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.02348481
5DNA deamination (GO:0045006)4.93669255
6regulation of cellular amino acid metabolic process (GO:0006521)4.72616645
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.62525319
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.62525319
9pyrimidine ribonucleoside catabolic process (GO:0046133)4.32034351
10DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.28879521
11antigen processing and presentation of endogenous antigen (GO:0019883)4.27660077
12positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.19591346
13negative regulation of ligase activity (GO:0051352)4.16440861
14negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.16440861
15intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.14781737
16signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.14781737
17protein maturation by protein folding (GO:0022417)4.13522151
18signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.08330158
19signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.08330158
20signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.08330158
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.01489150
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.96579037
23leukocyte aggregation (GO:0070486)3.95870833
24signal transduction involved in DNA damage checkpoint (GO:0072422)3.92808904
25signal transduction involved in DNA integrity checkpoint (GO:0072401)3.92808904
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.87256982
27signal transduction involved in cell cycle checkpoint (GO:0072395)3.82681296
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72992625
29positive regulation of gamma-delta T cell activation (GO:0046645)3.67386133
30positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.56063871
31regulation of cellular amine metabolic process (GO:0033238)3.54785930
32positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.54774091
33deoxyribose phosphate biosynthetic process (GO:0046385)3.52670034
342-deoxyribonucleotide biosynthetic process (GO:0009265)3.52670034
35Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52625695
36sequestering of actin monomers (GO:0042989)3.48515709
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.42494462
38deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.39603049
39ribosomal small subunit assembly (GO:0000028)3.38036416
40positive regulation of ligase activity (GO:0051351)3.37756056
41positive regulation of cell cycle arrest (GO:0071158)3.36094541
42antigen processing and presentation via MHC class Ib (GO:0002475)3.35756886
43immunoglobulin mediated immune response (GO:0016064)3.28447842
44respiratory burst (GO:0045730)3.26250824
45DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.20971886
46autophagic vacuole fusion (GO:0000046)3.19273056
47regulation of B cell receptor signaling pathway (GO:0050855)3.14663984
48signal peptide processing (GO:0006465)3.11303716
49negative regulation of T cell apoptotic process (GO:0070233)3.09751196
50organelle membrane fusion (GO:0090174)3.09735867
51regulation of ubiquitin-protein transferase activity (GO:0051438)3.05089680
52respiratory electron transport chain (GO:0022904)3.04450143
53negative regulation of B cell apoptotic process (GO:0002903)3.04087621
54cellular response to interferon-beta (GO:0035458)3.03954769
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.01818252
56establishment of viral latency (GO:0019043)3.00116885
57energy coupled proton transport, down electrochemical gradient (GO:0015985)2.98746278
58ATP synthesis coupled proton transport (GO:0015986)2.98746278
59electron transport chain (GO:0022900)2.98200450
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.97704772
61regulation of type I interferon-mediated signaling pathway (GO:0060338)2.95662925
62negative regulation of lymphocyte apoptotic process (GO:0070229)2.94655734
63regulation of ligase activity (GO:0051340)2.92938098
64chaperone-mediated protein transport (GO:0072321)2.92873185
65cellular response to type I interferon (GO:0071357)2.91343020
66type I interferon signaling pathway (GO:0060337)2.91343020
67regulation of chronic inflammatory response (GO:0002676)2.91015486
68response to type I interferon (GO:0034340)2.89953758
69pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.89494950
70regulation of response to interferon-gamma (GO:0060330)2.87333579
71negative regulation of protein ubiquitination (GO:0031397)2.87318839
72regulation of cell cycle arrest (GO:0071156)2.86368866
73chaperone mediated protein folding requiring cofactor (GO:0051085)2.85854773
74regulation of gamma-delta T cell differentiation (GO:0045586)2.85122184
75T cell migration (GO:0072678)2.85063600
76regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.83461697
77positive thymic T cell selection (GO:0045059)2.82554632
78B cell mediated immunity (GO:0019724)2.82472545
79purine deoxyribonucleotide catabolic process (GO:0009155)2.82076295
80response to interferon-beta (GO:0035456)2.80960146
81signal transduction in response to DNA damage (GO:0042770)2.79027650
82negative regulation of stress fiber assembly (GO:0051497)2.77737892
83cellular response to zinc ion (GO:0071294)2.77293876
84negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.75800400
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.75771108
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.75245195
87regulation of RIG-I signaling pathway (GO:0039535)2.74700652
88neutrophil activation involved in immune response (GO:0002283)2.73410195
89positive regulation of interleukin-8 secretion (GO:2000484)2.71154143
90NIK/NF-kappaB signaling (GO:0038061)2.70607387
91negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.70365536
92deoxyribonucleotide catabolic process (GO:0009264)2.69347579
93positive regulation of prostaglandin secretion (GO:0032308)2.69092669
94COPI coating of Golgi vesicle (GO:0048205)2.68537825
95Golgi transport vesicle coating (GO:0048200)2.68537825
96negative thymic T cell selection (GO:0045060)2.68258343
97tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68149829
98RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68149829
99response to peptidoglycan (GO:0032494)2.67899264
100regulation of gamma-delta T cell activation (GO:0046643)2.67697517
101negative regulation of viral genome replication (GO:0045071)2.65998083
102SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65660199
103negative regulation of leukocyte apoptotic process (GO:2000107)2.65461416
104positive regulation of T cell mediated cytotoxicity (GO:0001916)2.63692388
105negative T cell selection (GO:0043383)2.61643508
1062-deoxyribonucleotide metabolic process (GO:0009394)2.60423309
107negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.59821355
108negative regulation of phagocytosis (GO:0050765)2.59607088
109interferon-gamma production (GO:0032609)2.59265804
110deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.59004670
111positive regulation of lamellipodium assembly (GO:0010592)2.57046105
112deoxyribose phosphate catabolic process (GO:0046386)2.56426996
113telomere maintenance via semi-conservative replication (GO:0032201)2.56187855
114base-excision repair, AP site formation (GO:0006285)2.55729424
115iron-sulfur cluster assembly (GO:0016226)2.55178846
116metallo-sulfur cluster assembly (GO:0031163)2.55178846
117cotranslational protein targeting to membrane (GO:0006613)2.55152693
118protein targeting to ER (GO:0045047)2.55110493
119negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.54394092
120negative regulation of cell cycle G1/S phase transition (GO:1902807)2.54394092
121cytolysis (GO:0019835)2.53762788
122cellular extravasation (GO:0045123)2.53718651
123deoxyribose phosphate metabolic process (GO:0019692)2.53586594
124pyrimidine nucleoside catabolic process (GO:0046135)2.53147462
125pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.53064723
126regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.51927398
127positive regulation of monocyte chemotaxis (GO:0090026)2.49676859
128purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.49390478
129cellular response to interleukin-15 (GO:0071350)2.49375853
130actin nucleation (GO:0045010)2.49273562
131viral transcription (GO:0019083)2.49091885
132protein localization to endoplasmic reticulum (GO:0070972)2.48211545
133positive regulation of interferon-alpha production (GO:0032727)2.43207304
134proteasome assembly (GO:0043248)2.42284279
135regulation of B cell differentiation (GO:0045577)2.40721945
136cellular response to virus (GO:0098586)2.40496163
137interferon-gamma-mediated signaling pathway (GO:0060333)2.40062103
138translational termination (GO:0006415)2.39306970
139response to interleukin-15 (GO:0070672)2.38180529
140establishment of protein localization to endoplasmic reticulum (GO:0072599)2.37962402
141regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.36874112
142regulation of necroptotic process (GO:0060544)2.34778237
143antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.34012023
144telomere maintenance via recombination (GO:0000722)2.33587001
145regulation of T cell receptor signaling pathway (GO:0050856)2.32343990
146barbed-end actin filament capping (GO:0051016)2.32152486
147thymic T cell selection (GO:0045061)2.31476015
148DNA strand elongation involved in DNA replication (GO:0006271)2.31163002
149regulation of interferon-alpha production (GO:0032647)2.30289427
150negative regulation of myeloid cell apoptotic process (GO:0033033)2.30113523
151positive regulation of macrophage differentiation (GO:0045651)2.29167332
152mast cell activation (GO:0045576)2.28077141
153positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.25028837
154GDP-mannose metabolic process (GO:0019673)2.23116130
155T cell apoptotic process (GO:0070231)2.22876996
156translational elongation (GO:0006414)2.22131119
157positive regulation of lamellipodium organization (GO:1902745)2.21840103
158disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.19620261
159killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.19620261
160cellular response to exogenous dsRNA (GO:0071360)2.19508743
161DNA strand elongation (GO:0022616)2.18464932
162negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.17997555
163positive regulation of isotype switching (GO:0045830)2.17504052
164T cell costimulation (GO:0031295)2.16910916
165ribosomal small subunit biogenesis (GO:0042274)2.16694394
166natural killer cell activation (GO:0030101)2.15326755
167regulation of necrotic cell death (GO:0010939)2.14563074
168pentose-phosphate shunt (GO:0006098)2.14478941
169lymphocyte costimulation (GO:0031294)2.14417050
170mitochondrial calcium ion transport (GO:0006851)2.14157044
171L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.13424589
172DNA replication checkpoint (GO:0000076)2.12697581
173positive regulation of B cell differentiation (GO:0045579)2.12422134
174myeloid dendritic cell activation (GO:0001773)2.12274498
175positive regulation of alpha-beta T cell proliferation (GO:0046641)2.11614785
176leukocyte cell-cell adhesion (GO:0007159)2.11593043
177antigen receptor-mediated signaling pathway (GO:0050851)2.10142340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.67580113
2E2F7_22180533_ChIP-Seq_HELA_Human3.38673226
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.96520037
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.90205849
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.83343480
6SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.59589547
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38960230
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38264816
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38188278
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38054935
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.33923521
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33885665
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24820319
14FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.24375626
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16455738
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16393214
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.14028365
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07317601
19MYC_22102868_ChIP-Seq_BL_Human2.03924374
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03535175
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.03288533
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03249550
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99349296
24STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99303080
25SPI1_23547873_ChIP-Seq_NB4_Human1.93960786
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.90508874
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.86721510
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84920261
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.83365126
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.83218271
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80281102
32* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80207184
33SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77851286
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77612444
35* VDR_21846776_ChIP-Seq_THP-1_Human1.77129078
36MYB_26560356_Chip-Seq_TH2_Human1.74829365
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.74571994
38VDR_23849224_ChIP-Seq_CD4+_Human1.73702742
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71627213
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64641305
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60345040
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59608135
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.59472309
44BCL6_27268052_Chip-Seq_Bcells_Human1.58980313
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58338858
46* MAF_26560356_Chip-Seq_TH1_Human1.57994362
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57210334
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55153600
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.52353153
50* UTX_26944678_Chip-Seq_JUKART_Human1.51864320
51FOXP3_21729870_ChIP-Seq_TREG_Human1.50224055
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49885955
53* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48153861
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.47933770
55* MYB_26560356_Chip-Seq_TH1_Human1.47650520
56* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47104805
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47040889
58GABP_19822575_ChIP-Seq_HepG2_Human1.45991451
59DCP1A_22483619_ChIP-Seq_HELA_Human1.45680979
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.44938603
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43342565
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41388059
63* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41324250
64* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39135906
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.37791805
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.36823879
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.36409474
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35791974
69* XRN2_22483619_ChIP-Seq_HELA_Human1.33712767
70SCL_19346495_ChIP-Seq_HPC-7_Human1.32801489
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32782048
72BCOR_27268052_Chip-Seq_Bcells_Human1.32683846
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31677032
74* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31271671
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29568026
76* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29147609
77MAF_26560356_Chip-Seq_TH2_Human1.28907829
78* TET1_21451524_ChIP-Seq_MESCs_Mouse1.28548570
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28536137
80* VDR_24763502_ChIP-Seq_THP-1_Human1.26791322
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26750967
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26735330
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25517371
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25014703
85HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24685349
86* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21451173
87MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21084539
88P68_20966046_ChIP-Seq_HELA_Human1.20479015
89PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19031507
90* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18735249
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17894277
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17044414
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16839231
94LXR_22292898_ChIP-Seq_THP-1_Human1.16456099
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16036556
96CTCF_26484167_Chip-Seq_Bcells_Mouse1.15815765
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15779375
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15661774
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13571749
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12769299
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12501044
102PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12450634
103* ELK3_25401928_ChIP-Seq_HUVEC_Human1.11394152
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10194217
105ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10033561
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09928065
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09675306
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09651310
109EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09570638
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09424379
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08837738
112CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08621680
113* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08526620
114CIITA_25753668_ChIP-Seq_RAJI_Human1.08202005
115RUNX_20019798_ChIP-Seq_JUKART_Human1.08157321
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07689075
117RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07007050
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06863802
119CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05536446
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05209032
121EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04435279
122YY1_21170310_ChIP-Seq_MESCs_Mouse1.04114433
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03151441
124* KDM5A_27292631_Chip-Seq_BREAST_Human1.02771281
125P300_27268052_Chip-Seq_Bcells_Human0.99618826
126CTCF_20526341_ChIP-Seq_ESCs_Human0.98229123
127RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98018233
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97681881
129PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97248551
130ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95517075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.67118951
2MP0009785_altered_susceptibility_to3.08378742
3MP0005671_abnormal_response_to3.02063511
4MP0003763_abnormal_thymus_physiology2.98465612
5MP0003436_decreased_susceptibility_to2.93609113
6MP0000685_abnormal_immune_system2.84211168
7MP0003724_increased_susceptibility_to2.58216025
8MP0005025_abnormal_response_to2.52651451
9MP0005000_abnormal_immune_tolerance2.46902895
10MP0001800_abnormal_humoral_immune2.45434836
11MP0003693_abnormal_embryo_hatching2.44954665
12MP0009333_abnormal_splenocyte_physiolog2.28627434
13MP0002723_abnormal_immune_serum2.27736224
14MP0005387_immune_system_phenotype2.24500153
15MP0001790_abnormal_immune_system2.24500153
16MP0002452_abnormal_antigen_presenting2.23505227
17MP0002420_abnormal_adaptive_immunity2.21790715
18MP0001819_abnormal_immune_cell2.20958006
19MP0002419_abnormal_innate_immunity2.17109193
20MP0002148_abnormal_hypersensitivity_rea2.16127731
21MP0002166_altered_tumor_susceptibility2.08849087
22MP0006082_CNS_inflammation2.08029149
23MP0002398_abnormal_bone_marrow2.04260907
24MP0002405_respiratory_system_inflammati2.03641850
25MP0002006_tumorigenesis1.87532518
26MP0000716_abnormal_immune_system1.87220903
27MP0010155_abnormal_intestine_physiology1.85388023
28MP0002396_abnormal_hematopoietic_system1.84929227
29MP0001853_heart_inflammation1.81771535
30MP0001845_abnormal_inflammatory_respons1.78512449
31MP0000689_abnormal_spleen_morphology1.77718710
32MP0002722_abnormal_immune_system1.76020464
33MP0000490_abnormal_crypts_of1.75235063
34MP0005464_abnormal_platelet_physiology1.75032868
35MP0003186_abnormal_redox_activity1.67578341
36MP0000858_altered_metastatic_potential1.66826409
37MP0002429_abnormal_blood_cell1.64498541
38MP0008875_abnormal_xenobiotic_pharmacok1.64373057
39MP0003806_abnormal_nucleotide_metabolis1.60290474
40MP0001873_stomach_inflammation1.56142087
41MP0001905_abnormal_dopamine_level1.53131526
42MP0008469_abnormal_protein_level1.52544501
43MP0004947_skin_inflammation1.51699176
44MP0009840_abnormal_foam_cell1.50686677
45MP0005451_abnormal_body_composition1.48091817
46MP0004510_myositis1.47365873
47MP0008260_abnormal_autophagy1.46808272
48MP0005166_decreased_susceptibility_to1.43979315
49MP0003303_peritoneal_inflammation1.42642910
50MP0004957_abnormal_blastocyst_morpholog1.41066332
51MP0003191_abnormal_cellular_cholesterol1.40417314
52MP0002132_abnormal_respiratory_system1.40095553
53MP0001533_abnormal_skeleton_physiology1.39558282
54MP0001545_abnormal_hematopoietic_system1.39183563
55MP0005397_hematopoietic_system_phenotyp1.39183563
56MP0003075_altered_response_to1.39128329
57MP0005310_abnormal_salivary_gland1.39117845
58MP0000703_abnormal_thymus_morphology1.36977754
59MP0002138_abnormal_hepatobiliary_system1.36246892
60MP0003866_abnormal_defecation1.34144550
61MP0003077_abnormal_cell_cycle1.33265520
62MP0002933_joint_inflammation1.31047022
63MP0002019_abnormal_tumor_incidence1.25629517
64MP0009764_decreased_sensitivity_to1.25598423
65MP0000343_altered_response_to1.20692362
66MP0003111_abnormal_nucleus_morphology1.17745482
67MP0010094_abnormal_chromosome_stability1.14224611
68MP0000465_gastrointestinal_hemorrhage1.08632365
69MP0002139_abnormal_hepatobiliary_system1.06935626
70MP0001764_abnormal_homeostasis1.05065013
71MP0001881_abnormal_mammary_gland1.04333336
72MP0004782_abnormal_surfactant_physiolog1.03901117
73MP0005058_abnormal_lysosome_morphology1.03602991
74MP0003656_abnormal_erythrocyte_physiolo1.03553018
75MP0004808_abnormal_hematopoietic_stem1.02816738
76MP0000372_irregular_coat_pigmentation1.01700803
77MP0005165_increased_susceptibility_to1.00537658
78MP0005360_urolithiasis0.98116732
79MP0003448_altered_tumor_morphology0.95819807
80MP0005075_abnormal_melanosome_morpholog0.95294136
81MP0000609_abnormal_liver_physiology0.93770629
82MP0008872_abnormal_physiological_respon0.93271919
83MP0009763_increased_sensitivity_to0.93243781
84MP0001727_abnormal_embryo_implantation0.92125168
85MP0003300_gastrointestinal_ulcer0.91392790
86MP0008873_increased_physiological_sensi0.91108678
87MP0005023_abnormal_wound_healing0.90747357
88MP0004381_abnormal_hair_follicle0.88243737
89MP0005365_abnormal_bile_salt0.87558371
90MP0008007_abnormal_cellular_replicative0.84813507
91MP0005584_abnormal_enzyme/coenzyme_acti0.84514383
92MP0010352_gastrointestinal_tract_polyps0.83235923
93MP0006035_abnormal_mitochondrial_morpho0.82453649
94MP0009643_abnormal_urine_homeostasis0.82350560
95MP0002693_abnormal_pancreas_physiology0.82213051
96MP0002277_abnormal_respiratory_mucosa0.81917874
97MP0008058_abnormal_DNA_repair0.81478313
98MP0009278_abnormal_bone_marrow0.78676897
99MP0001851_eye_inflammation0.78347428
100MP0005319_abnormal_enzyme/_coenzyme0.77408250
101MP0006036_abnormal_mitochondrial_physio0.76970919
102MP0000598_abnormal_liver_morphology0.74698450
103MP0002653_abnormal_ependyma_morphology0.73691932
104MP0002876_abnormal_thyroid_physiology0.72653227
105MP0005220_abnormal_exocrine_pancreas0.72571023
106MP0000313_abnormal_cell_death0.72210455
107MP0005410_abnormal_fertilization0.72078552
108MP0006054_spinal_hemorrhage0.70932438
109MP0008932_abnormal_embryonic_tissue0.70683871
110MP0005501_abnormal_skin_physiology0.69049522
111MP0000477_abnormal_intestine_morphology0.68813254
112MP0005084_abnormal_gallbladder_morpholo0.67589231
113MP0002877_abnormal_melanocyte_morpholog0.67392018
114MP0005083_abnormal_biliary_tract0.66623162
115MP0005395_other_phenotype0.66411835
116MP0003786_premature_aging0.65192639
117MP0005636_abnormal_mineral_homeostasis0.65086340
118MP0001663_abnormal_digestive_system0.64877194
119MP0003718_maternal_effect0.64012000
120MP0002163_abnormal_gland_morphology0.63260286
121MP0001666_abnormal_nutrient_absorption0.63082374
122MP0002136_abnormal_kidney_physiology0.62321253
123MP0000358_abnormal_cell_content/0.61241373

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.75574131
2Eczematoid dermatitis (HP:0000976)4.50085111
3Recurrent abscess formation (HP:0002722)4.29473682
4Mitochondrial inheritance (HP:0001427)3.87826515
5Abnormal mitochondria in muscle tissue (HP:0008316)3.78522036
6Myositis (HP:0100614)3.78161714
7Recurrent bacterial skin infections (HP:0005406)3.74661912
8Hepatocellular necrosis (HP:0001404)3.73442399
9IgM deficiency (HP:0002850)3.65881898
10Acute necrotizing encephalopathy (HP:0006965)3.64538892
11Recurrent bronchitis (HP:0002837)3.50633958
12Recurrent gram-negative bacterial infections (HP:0005420)3.47054049
13Hepatic necrosis (HP:0002605)3.41614784
14Recurrent fungal infections (HP:0002841)3.33531733
15Combined immunodeficiency (HP:0005387)3.29929010
16Increased intramyocellular lipid droplets (HP:0012240)3.25454243
17Abnormality of T cells (HP:0002843)3.24444812
18Increased CSF lactate (HP:0002490)3.15941974
19Abnormality of T cell physiology (HP:0011840)3.15622519
20Thrombocytosis (HP:0001894)3.14371800
21Abnormality of T cell number (HP:0011839)3.11892855
22Severe combined immunodeficiency (HP:0004430)3.10399788
23Acute encephalopathy (HP:0006846)3.09992883
24T lymphocytopenia (HP:0005403)3.08926557
25Cerebral palsy (HP:0100021)3.07646649
26Chronic mucocutaneous candidiasis (HP:0002728)3.07132715
27Recurrent cutaneous fungal infections (HP:0011370)3.07132715
28Pustule (HP:0200039)3.04932599
29Recurrent skin infections (HP:0001581)3.03172283
30Increased muscle lipid content (HP:0009058)2.99720821
31Petechiae (HP:0000967)2.94148846
32Reduced antithrombin III activity (HP:0001976)2.90594791
33Cholecystitis (HP:0001082)2.88200965
34Abnormal gallbladder physiology (HP:0012438)2.88200965
35Recurrent viral infections (HP:0004429)2.85793058
36Progressive macrocephaly (HP:0004481)2.83500352
37Vacuolated lymphocytes (HP:0001922)2.82513411
38Abnormality of macrophages (HP:0004311)2.82417596
39IgG deficiency (HP:0004315)2.80643603
40Chronic otitis media (HP:0000389)2.78915564
41Hypokinesia (HP:0002375)2.78061898
42Cerebral edema (HP:0002181)2.72882636
43Increased IgM level (HP:0003496)2.70922350
44Orchitis (HP:0100796)2.69201956
45Mediastinal lymphadenopathy (HP:0100721)2.68960985
46Meningitis (HP:0001287)2.68689662
47Abnormality of B cell number (HP:0010975)2.64547164
48B lymphocytopenia (HP:0010976)2.64547164
49Aplastic anemia (HP:0001915)2.63366895
50Pancytopenia (HP:0001876)2.61971396
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.61879789
52Nasal polyposis (HP:0100582)2.59867003
53Autoimmune thrombocytopenia (HP:0001973)2.59499998
54Obstructive lung disease (HP:0006536)2.58592128
55Chronic obstructive pulmonary disease (HP:0006510)2.58592128
56Lymphopenia (HP:0001888)2.57781267
57Renal Fanconi syndrome (HP:0001994)2.57206327
58Abnormality of cells of the lymphoid lineage (HP:0012140)2.55283974
59Interstitial pulmonary disease (HP:0006530)2.55143299
60Hypoproteinemia (HP:0003075)2.54779167
61Abnormality of cells of the erythroid lineage (HP:0012130)2.49903843
62Dicarboxylic aciduria (HP:0003215)2.49428157
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49428157
64Abnormality of the nasal mucosa (HP:0000433)2.48620313
65Increased hepatocellular lipid droplets (HP:0006565)2.47515347
663-Methylglutaconic aciduria (HP:0003535)2.47332535
67Rough bone trabeculation (HP:0100670)2.46543101
68Type I transferrin isoform profile (HP:0003642)2.45178830
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.45042656
70Stomatitis (HP:0010280)2.44922949
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43319885
72Lactic acidosis (HP:0003128)2.42087555
73Vasculitis (HP:0002633)2.41583677
74Exercise intolerance (HP:0003546)2.40773518
75Panhypogammaglobulinemia (HP:0003139)2.39161364
76Poor head control (HP:0002421)2.39019117
77Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37802631
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37802631
79Agammaglobulinemia (HP:0004432)2.35115627
80Abnormal number of erythroid precursors (HP:0012131)2.34091751
81Urticaria (HP:0001025)2.31750737
82Hypergammaglobulinemia (HP:0010702)2.31632301
83Increased serum lactate (HP:0002151)2.31175905
84Progressive neurologic deterioration (HP:0002344)2.30976060
85Hepatosplenomegaly (HP:0001433)2.30860204
86Gingivitis (HP:0000230)2.30198021
87Microcytic anemia (HP:0001935)2.29713474
88Lipid accumulation in hepatocytes (HP:0006561)2.28507334
89Leukocytosis (HP:0001974)2.26518808
90Autoimmune hemolytic anemia (HP:0001890)2.24655174
91Bronchitis (HP:0012387)2.22514095
92Retrobulbar optic neuritis (HP:0100654)2.22422638
93Optic neuritis (HP:0100653)2.22422638
94Abnormality of glycolipid metabolism (HP:0010969)2.22224789
95Abnormality of liposaccharide metabolism (HP:0010968)2.22224789
96Abnormality of glycosphingolipid metabolism (HP:0004343)2.22224789
97Cellulitis (HP:0100658)2.20501977
98Abnormality of eosinophils (HP:0001879)2.20203882
99Testicular atrophy (HP:0000029)2.20146358
100Abnormal protein glycosylation (HP:0012346)2.18596276
101Abnormal glycosylation (HP:0012345)2.18596276
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18596276
103Abnormal protein N-linked glycosylation (HP:0012347)2.18596276
104Hypertensive crisis (HP:0100735)2.14847882
105Hemoptysis (HP:0002105)2.14557425
106Epistaxis (HP:0000421)2.14398442
107Thyroiditis (HP:0100646)2.14300859
108Granulocytopenia (HP:0001913)2.14267427
109Acute hepatic failure (HP:0006554)2.13649264
110Reticulocytopenia (HP:0001896)2.13120484
111Respiratory failure (HP:0002878)2.11090813
112Hypoplasia of the thymus (HP:0000778)2.10508329
113Microvesicular hepatic steatosis (HP:0001414)2.05653468
114Recurrent sinusitis (HP:0011108)2.05295220
115Chronic diarrhea (HP:0002028)2.02596106
116Abnormality of the prostate (HP:0008775)2.02583821
117Generalized aminoaciduria (HP:0002909)2.01398930
118Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.01173810
119Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99936086
120Encephalitis (HP:0002383)1.99410293
121Exertional dyspnea (HP:0002875)1.98311775
122Eosinophilia (HP:0001880)1.98009631
123Poikiloderma (HP:0001029)1.97349602
124Pulmonary infiltrates (HP:0002113)1.97325012
125Lymphoma (HP:0002665)1.97254470
126Neutropenia (HP:0001875)1.96301626
127Joint swelling (HP:0001386)1.96031390
128Multiple enchondromatosis (HP:0005701)1.95848218
129Skin rash (HP:0000988)1.95615384
130Microretrognathia (HP:0000308)1.94398485
131Emotional lability (HP:0000712)1.93919043
132Oral leukoplakia (HP:0002745)1.93845750
133Seborrheic dermatitis (HP:0001051)1.92383488
134Cheilitis (HP:0100825)1.91681469
135Gastrointestinal inflammation (HP:0004386)1.90324668
136Gingival bleeding (HP:0000225)1.90229940
137Recurrent pneumonia (HP:0006532)1.89685441
138Growth hormone excess (HP:0000845)1.89027691
139Gastrointestinal infarctions (HP:0005244)1.88673815
140Purpura (HP:0000979)1.88435950
141Spontaneous hematomas (HP:0007420)1.88219292
142Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86854165
143Sparse eyelashes (HP:0000653)1.85856271
144Inflammation of the large intestine (HP:0002037)1.85345565
145Reduced subcutaneous adipose tissue (HP:0003758)1.85066366
146Skin ulcer (HP:0200042)1.84339992
147Periodontitis (HP:0000704)1.83031662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.21450292
2MAP4K13.84946438
3ERN13.23199655
4NME22.73585327
5BLK2.68802824
6TXK2.66798881
7ZAP702.64762100
8LIMK12.41600087
9BUB12.39329439
10KDR2.38616580
11TYK22.33536926
12TESK22.30983890
13TBK12.30457830
14IKBKE2.27707889
15JAK32.21401879
16EIF2AK12.16902986
17IRAK42.10792694
18EIF2AK31.89671459
19TAOK31.88165614
20KIT1.86370119
21TEC1.78378079
22PIM21.73730319
23EPHA21.69573635
24BTK1.63981281
25STK101.62956026
26FGFR41.59301443
27STK161.54787167
28NLK1.52878277
29IRAK31.45902360
30RPS6KA41.45589321
31ACVR1B1.37556200
32FLT31.33433970
33MAP2K31.32667902
34MAP3K141.32148424
35MAP3K121.30659698
36DAPK11.28121789
37NME11.27824365
38BCKDK1.26284797
39ARAF1.26116400
40MAP3K111.23737143
41MOS1.21276591
42GRK61.20587983
43PLK41.19346148
44SYK1.19000023
45ITK1.16043632
46TAOK21.15159873
47MAPKAPK31.13063242
48IKBKB1.10970832
49JAK11.09815857
50MAP3K101.06751033
51FES1.03785289
52MAP3K131.02841796
53CSK1.00840309
54TNK20.97829880
55PIM10.97582070
56LRRK20.94581554
57AURKA0.94421506
58LCK0.94054675
59NEK20.90576317
60ABL20.87343095
61TESK10.87326108
62CSF1R0.85988487
63LYN0.85846479
64MAPK110.82894422
65RAF10.81770820
66CSNK1G30.79809164
67VRK10.76114924
68PRKCI0.75706489
69PKN20.74695403
70TGFBR20.74422824
71TAOK10.74067307
72RIPK40.72753656
73PAK10.72431215
74NEK90.71434324
75MAP3K30.70780978
76HCK0.70379315
77TRIB30.68403096
78SCYL20.68222167
79CDK80.66327323
80MST40.66073395
81PAK40.65726321
82TLK10.65203449
83RPS6KB20.64939311
84PRKCQ0.64676234
85GRK70.64180932
86WEE10.63996179
87JAK20.63985929
88LMTK20.63899959
89PBK0.62824143
90MAP4K20.62026443
91SRPK10.60900986
92BRAF0.60458540
93MAP3K80.60265575
94EEF2K0.60250576
95CHUK0.58194272
96MUSK0.57984241
97STK40.57526504
98AURKB0.56382095
99CDK40.55672621
100BRSK20.55197580
101MST1R0.55128926
102PRKG20.53848959
103CDC70.52853469
104ILK0.52101962
105SMG10.51546863
106ZAK0.51254681
107DYRK30.50888020
108NEK10.46840885
109MAP2K20.46542749
110GRK50.46310123
111BRSK10.46033710
112CDK70.45988194
113BMPR20.44621873
114MARK30.44616764
115CLK10.44542406
116PLK10.43418034
117CSNK1G10.42119666
118HIPK20.41842977
119MAP3K60.41002673
120MYLK0.40871313
121EIF2AK20.39025846
122MAP3K90.39010445
123CSNK1A1L0.37495892
124RPS6KA50.37389999
125FGFR30.36139433
126MAPKAPK20.34961098
127CDK90.33788567
128PRKCD0.32302232
129MAP2K60.31217395
130SIK30.31154029
131CSNK1G20.30442213
132CAMK2G0.30089838
133DAPK30.29479914
134ADRBK20.28557797
135NUAK10.28276921
136CSNK2A10.27549909
137PRKD10.25717953

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.12246854
2Oxidative phosphorylation_Homo sapiens_hsa001902.86926597
3DNA replication_Homo sapiens_hsa030302.74385105
4Ribosome_Homo sapiens_hsa030102.58025711
5Parkinsons disease_Homo sapiens_hsa050122.55647191
6Proteasome_Homo sapiens_hsa030502.52263613
7Protein export_Homo sapiens_hsa030602.41406522
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.33910666
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.03087615
10Mismatch repair_Homo sapiens_hsa034301.96288074
11Base excision repair_Homo sapiens_hsa034101.93393080
12Leishmaniasis_Homo sapiens_hsa051401.90868971
13Folate biosynthesis_Homo sapiens_hsa007901.79331534
14Antigen processing and presentation_Homo sapiens_hsa046121.78291273
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.76311357
16RNA polymerase_Homo sapiens_hsa030201.75718135
17Measles_Homo sapiens_hsa051621.75032601
18Pyrimidine metabolism_Homo sapiens_hsa002401.67618510
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64048964
20Other glycan degradation_Homo sapiens_hsa005111.63730811
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63013544
22Huntingtons disease_Homo sapiens_hsa050161.61211270
23Type I diabetes mellitus_Homo sapiens_hsa049401.57492090
24Homologous recombination_Homo sapiens_hsa034401.56438173
25Alzheimers disease_Homo sapiens_hsa050101.55527518
26Herpes simplex infection_Homo sapiens_hsa051681.53088154
27Hematopoietic cell lineage_Homo sapiens_hsa046401.50954856
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48346439
29Nucleotide excision repair_Homo sapiens_hsa034201.47463160
30Staphylococcus aureus infection_Homo sapiens_hsa051501.46027562
31Sulfur relay system_Homo sapiens_hsa041221.44318887
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43080586
33Sulfur metabolism_Homo sapiens_hsa009201.40966820
34Legionellosis_Homo sapiens_hsa051341.36370715
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33834161
36Fatty acid elongation_Homo sapiens_hsa000621.32855708
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32389756
38Pentose phosphate pathway_Homo sapiens_hsa000301.28480430
39Graft-versus-host disease_Homo sapiens_hsa053321.28200959
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26803776
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26222901
42Rheumatoid arthritis_Homo sapiens_hsa053231.24611778
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21121466
44Allograft rejection_Homo sapiens_hsa053301.20115015
45Cell cycle_Homo sapiens_hsa041101.14266327
46Shigellosis_Homo sapiens_hsa051311.11727900
47p53 signaling pathway_Homo sapiens_hsa041151.10240165
48Osteoclast differentiation_Homo sapiens_hsa043801.09463489
49Spliceosome_Homo sapiens_hsa030401.08854899
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05031493
51T cell receptor signaling pathway_Homo sapiens_hsa046601.04063729
52RNA degradation_Homo sapiens_hsa030181.02619012
53One carbon pool by folate_Homo sapiens_hsa006701.02249969
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.01010737
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98648738
56Non-homologous end-joining_Homo sapiens_hsa034500.98601174
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.97686052
58Caffeine metabolism_Homo sapiens_hsa002320.96782534
59Apoptosis_Homo sapiens_hsa042100.96771339
60Influenza A_Homo sapiens_hsa051640.95781681
61Vibrio cholerae infection_Homo sapiens_hsa051100.93740249
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93131662
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93107372
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92574783
65B cell receptor signaling pathway_Homo sapiens_hsa046620.92222860
66Asthma_Homo sapiens_hsa053100.90168035
67Pertussis_Homo sapiens_hsa051330.88658861
68Tuberculosis_Homo sapiens_hsa051520.87698044
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86182233
70Malaria_Homo sapiens_hsa051440.85611870
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.82781414
72Basal transcription factors_Homo sapiens_hsa030220.80592292
73Hepatitis B_Homo sapiens_hsa051610.79743565
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78915674
75Lysosome_Homo sapiens_hsa041420.78134410
76Selenocompound metabolism_Homo sapiens_hsa004500.77487298
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76401651
78Acute myeloid leukemia_Homo sapiens_hsa052210.73588773
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73035901
80Epstein-Barr virus infection_Homo sapiens_hsa051690.72907422
81Toxoplasmosis_Homo sapiens_hsa051450.72212169
82Phenylalanine metabolism_Homo sapiens_hsa003600.70761327
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.69573686
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68702258
85RNA transport_Homo sapiens_hsa030130.68047030
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67652441
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66211817
88Collecting duct acid secretion_Homo sapiens_hsa049660.65719671
89TNF signaling pathway_Homo sapiens_hsa046680.64715681
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64633591
91Regulation of autophagy_Homo sapiens_hsa041400.64564680
92N-Glycan biosynthesis_Homo sapiens_hsa005100.63966597
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.62116977
94Viral myocarditis_Homo sapiens_hsa054160.62067853
95Glutathione metabolism_Homo sapiens_hsa004800.59669136
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59416175
97Purine metabolism_Homo sapiens_hsa002300.58863513
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58108094
99Fanconi anemia pathway_Homo sapiens_hsa034600.56110634
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55289555
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54418371
102Salmonella infection_Homo sapiens_hsa051320.53953539
103Autoimmune thyroid disease_Homo sapiens_hsa053200.53316920
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.52616459
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52118168
106Galactose metabolism_Homo sapiens_hsa000520.51806604
107Peroxisome_Homo sapiens_hsa041460.50869494
108Complement and coagulation cascades_Homo sapiens_hsa046100.50566425
109Metabolic pathways_Homo sapiens_hsa011000.49368041
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48828686
111Tyrosine metabolism_Homo sapiens_hsa003500.48576292
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48538100
113Pancreatic cancer_Homo sapiens_hsa052120.48090893
114Hepatitis C_Homo sapiens_hsa051600.47846885
115Carbon metabolism_Homo sapiens_hsa012000.47681317
116Biosynthesis of amino acids_Homo sapiens_hsa012300.46955110
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.46855354
118HTLV-I infection_Homo sapiens_hsa051660.46597056
119Histidine metabolism_Homo sapiens_hsa003400.46583815
120Cardiac muscle contraction_Homo sapiens_hsa042600.44472036
121Fructose and mannose metabolism_Homo sapiens_hsa000510.43517525
122Thyroid cancer_Homo sapiens_hsa052160.43241617
123Chemokine signaling pathway_Homo sapiens_hsa040620.42315235
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39927361
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39530836
126Phagosome_Homo sapiens_hsa041450.39362226
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38693051
128Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37353944
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34216413
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32411378
131Chemical carcinogenesis_Homo sapiens_hsa052040.30311488

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »