CDK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.76944964
2mannose metabolic process (GO:0006013)4.61267909
3response to peptidoglycan (GO:0032494)4.09532445
4cellular extravasation (GO:0045123)3.93462136
5positive regulation of gamma-delta T cell activation (GO:0046645)3.85786394
6neutrophil activation involved in immune response (GO:0002283)3.82642709
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.67781942
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49357665
9antigen processing and presentation of endogenous antigen (GO:0019883)3.48259556
10positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.47190780
11germinal center formation (GO:0002467)3.46978741
12negative regulation of cell killing (GO:0031342)3.44489562
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.44489562
14positive regulation by symbiont of host defense response (GO:0052509)3.43270231
15modulation by symbiont of host defense response (GO:0052031)3.43270231
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.43270231
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.43270231
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.43270231
19modulation by symbiont of host immune response (GO:0052553)3.43270231
20regulation of ARF GTPase activity (GO:0032312)3.38659112
21detection of other organism (GO:0098543)3.36004863
22histone H3-K36 demethylation (GO:0070544)3.33306492
23detection of bacterium (GO:0016045)3.31499025
24macrophage activation involved in immune response (GO:0002281)3.31482616
25response to muramyl dipeptide (GO:0032495)3.17226581
26NIK/NF-kappaB signaling (GO:0038061)3.06366257
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.05313687
28regulation of type I interferon-mediated signaling pathway (GO:0060338)3.02289091
29positive regulation of Cdc42 GTPase activity (GO:0043089)3.00536540
30regulation of gamma-delta T cell activation (GO:0046643)2.98751628
31detection of external biotic stimulus (GO:0098581)2.96463548
32regulation of T-helper 2 cell differentiation (GO:0045628)2.91289321
33positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.90168490
34lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87084969
35regulation of leukocyte degranulation (GO:0043300)2.86870403
36regulation of mast cell degranulation (GO:0043304)2.86653623
37negative regulation of granulocyte differentiation (GO:0030853)2.86345530
38detection of molecule of bacterial origin (GO:0032490)2.85441403
39regulation of myeloid leukocyte mediated immunity (GO:0002886)2.84743355
40barbed-end actin filament capping (GO:0051016)2.84017395
413-UTR-mediated mRNA stabilization (GO:0070935)2.83364971
42regulation of chemokine biosynthetic process (GO:0045073)2.82029897
43negative regulation of interleukin-12 production (GO:0032695)2.81892585
44regulation of interferon-beta biosynthetic process (GO:0045357)2.81579763
45positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.80968527
46regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.75216534
47epithelial cell differentiation involved in prostate gland development (GO:0060742)2.73803240
48detection of biotic stimulus (GO:0009595)2.71386788
49regulation of monocyte differentiation (GO:0045655)2.69157721
50immunoglobulin mediated immune response (GO:0016064)2.67764933
51response to type I interferon (GO:0034340)2.64160540
52regulation of gamma-delta T cell differentiation (GO:0045586)2.61335374
53negative regulation of interleukin-8 production (GO:0032717)2.59595657
54type I interferon signaling pathway (GO:0060337)2.59219509
55cellular response to type I interferon (GO:0071357)2.59219509
56negative regulation of phagocytosis (GO:0050765)2.59029090
57leukocyte aggregation (GO:0070486)2.56532259
58diacylglycerol metabolic process (GO:0046339)2.56062913
59negative regulation of toll-like receptor signaling pathway (GO:0034122)2.55510445
60apoptotic process involved in morphogenesis (GO:0060561)2.53608475
61negative regulation of cytokine production involved in immune response (GO:0002719)2.53270914
62response to laminar fluid shear stress (GO:0034616)2.51176063
63positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.50986017
64regulation of mast cell activation involved in immune response (GO:0033006)2.44541998
65regulation of necroptotic process (GO:0060544)2.44085490
66pinocytosis (GO:0006907)2.43498809
67positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.42947783
68macrophage activation (GO:0042116)2.41462145
69negative regulation of cell size (GO:0045792)2.40193327
70positive regulation of tumor necrosis factor production (GO:0032760)2.39824740
71thymic T cell selection (GO:0045061)2.38314445
72positive regulation of extracellular matrix organization (GO:1903055)2.37442512
73positive regulation of chemokine biosynthetic process (GO:0045080)2.36932747
74histone lysine demethylation (GO:0070076)2.35900159
75B cell receptor signaling pathway (GO:0050853)2.35695652
76histone H3-K9 demethylation (GO:0033169)2.34712163
77myeloid cell activation involved in immune response (GO:0002275)2.34581970
78regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.34265918
79positive regulation of cellular amide metabolic process (GO:0034250)2.31273223
80positive regulation of B cell differentiation (GO:0045579)2.30643795
81histone H4 deacetylation (GO:0070933)2.30118930
82protein localization to endosome (GO:0036010)2.30081460
83modulation by symbiont of host cellular process (GO:0044068)2.29138163
84granulocyte activation (GO:0036230)2.29027051
85low-density lipoprotein particle clearance (GO:0034383)2.28723125
86stress fiber assembly (GO:0043149)2.28671572
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.27902791
88regulation of histone H3-K27 methylation (GO:0061085)2.27735335
89regulation of tumor necrosis factor production (GO:0032680)2.27453757
90regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.27234644
91neutrophil activation (GO:0042119)2.26833510
92embryonic process involved in female pregnancy (GO:0060136)2.26498680
93regulation of extracellular matrix disassembly (GO:0010715)2.25329413
94regulation of regulated secretory pathway (GO:1903305)2.25168122
95retrograde transport, endosome to Golgi (GO:0042147)2.24637074
96histone demethylation (GO:0016577)2.23829791
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.23164152
98regulation of phagocytosis (GO:0050764)2.22839124
99T cell selection (GO:0045058)2.22284854
100semaphorin-plexin signaling pathway (GO:0071526)2.21516616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.31101240
2MYC_22102868_ChIP-Seq_BL_Human2.96712488
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.73145564
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.66026909
5* LXR_22292898_ChIP-Seq_THP-1_Human2.61207080
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.55414060
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.54856108
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.54114876
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.46800215
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.44194775
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33718406
12KDM2B_26808549_Chip-Seq_DND41_Human2.30244212
13TCF7_22412390_ChIP-Seq_EML_Mouse2.28256782
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.20135713
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19197820
16VDR_24763502_ChIP-Seq_THP-1_Human2.16008461
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.07439851
18RACK7_27058665_Chip-Seq_MCF-7_Human2.04733527
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.02384316
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94318624
21MAF_26560356_Chip-Seq_TH1_Human1.89965278
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85564397
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84037434
24MAF_26560356_Chip-Seq_TH2_Human1.80412348
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79613876
26UTX_26944678_Chip-Seq_JUKART_Human1.78648281
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75825263
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.72143883
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69521892
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62331056
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.61371201
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61353584
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58983308
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.56317163
35SPI1_23127762_ChIP-Seq_K562_Human1.52836177
36P68_20966046_ChIP-Seq_HELA_Human1.51708310
37* KDM2B_26808549_Chip-Seq_K562_Human1.51373702
38* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47135460
39SA1_27219007_Chip-Seq_ERYTHROID_Human1.46872159
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44734594
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.42953672
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41977462
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.40817257
44SPI1_23547873_ChIP-Seq_NB4_Human1.40475577
45KDM2B_26808549_Chip-Seq_JURKAT_Human1.39967006
46* SMC4_20622854_ChIP-Seq_HELA_Human1.39074224
47* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36043826
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.35230984
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33973845
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33717506
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.32377763
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32222431
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31792881
54NCOR1_26117541_ChIP-Seq_K562_Human1.31401696
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30749029
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30284907
57* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29563344
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29453391
59CREB1_26743006_Chip-Seq_LNCaP_Human1.28163770
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27574521
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27120858
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26922746
63SCL_19346495_ChIP-Seq_HPC-7_Human1.26777974
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26705530
65BCOR_27268052_Chip-Seq_Bcells_Human1.26186177
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25468738
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.25077565
68* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21924463
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.21620028
70* RXR_22158963_ChIP-Seq_LIVER_Mouse1.21436949
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21412559
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21290718
73CLOCK_20551151_ChIP-Seq_293T_Human1.21228593
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20224329
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.20044114
76* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20030391
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19511818
78MYB_26560356_Chip-Seq_TH1_Human1.19089723
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17977712
80SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16818048
81BCL6_27268052_Chip-Seq_Bcells_Human1.16568538
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.15944196
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12629013
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10237708
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10040626
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08999667
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08501055
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07318820
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06837482
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06778197
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06612123
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05606672
93ZNF263_19887448_ChIP-Seq_K562_Human1.05463623
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04401882
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03881857
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03215525
97FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01611168
98ATF3_27146783_Chip-Seq_COLON_Human1.01114097
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99654677
100GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99376614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.83339776
2MP0003436_decreased_susceptibility_to3.52267924
3MP0003303_peritoneal_inflammation3.50999450
4MP0003172_abnormal_lysosome_physiology3.00063624
5MP0003705_abnormal_hypodermis_morpholog2.83683342
6MP0005451_abnormal_body_composition2.83664816
7MP0003724_increased_susceptibility_to2.35581420
8MP0009278_abnormal_bone_marrow2.34712657
9MP0001835_abnormal_antigen_presentation2.28579701
10MP0002419_abnormal_innate_immunity2.26187990
11MP0001849_ear_inflammation2.24610014
12MP0009840_abnormal_foam_cell2.14934546
13MP0005025_abnormal_response_to2.09152743
14MP0005076_abnormal_cell_differentiation2.08249898
15MP0002132_abnormal_respiratory_system1.98985919
16MP0009785_altered_susceptibility_to1.97420328
17MP0008260_abnormal_autophagy1.97133418
18MP0005000_abnormal_immune_tolerance1.95055062
19MP0000685_abnormal_immune_system1.91705345
20MP0000858_altered_metastatic_potential1.90065661
21MP0003300_gastrointestinal_ulcer1.89157066
22MP0010234_abnormal_vibrissa_follicle1.86247149
23MP0004947_skin_inflammation1.85644237
24MP0001790_abnormal_immune_system1.83435472
25MP0005387_immune_system_phenotype1.83435472
26MP0001800_abnormal_humoral_immune1.81148172
27MP0003763_abnormal_thymus_physiology1.80490206
28MP0001533_abnormal_skeleton_physiology1.67344900
29MP0002452_abnormal_antigen_presenting1.67253811
30MP0001819_abnormal_immune_cell1.65607044
31MP0002420_abnormal_adaptive_immunity1.65311552
32MP0002396_abnormal_hematopoietic_system1.64834476
33MP0002723_abnormal_immune_serum1.64716768
34MP0002148_abnormal_hypersensitivity_rea1.59759145
35MP0004510_myositis1.59105316
36MP0006082_CNS_inflammation1.56115449
37MP0003191_abnormal_cellular_cholesterol1.55153309
38MP0010155_abnormal_intestine_physiology1.54055756
39MP0009333_abnormal_splenocyte_physiolog1.52835590
40MP0003453_abnormal_keratinocyte_physiol1.52811307
41MP0005464_abnormal_platelet_physiology1.51680097
42MP0002405_respiratory_system_inflammati1.45965458
43MP0002998_abnormal_bone_remodeling1.42873492
44MP0008004_abnormal_stomach_pH1.41446153
45MP0001545_abnormal_hematopoietic_system1.40255053
46MP0005397_hematopoietic_system_phenotyp1.40255053
47MP0005671_abnormal_response_to1.35405680
48MP0004185_abnormal_adipocyte_glucose1.35391756
49MP0002398_abnormal_bone_marrow1.32219802
50MP0001845_abnormal_inflammatory_respons1.25368740
51MP0000716_abnormal_immune_system1.25059505
52MP0001853_heart_inflammation1.22506493
53MP0005666_abnormal_adipose_tissue1.19906976
54MP0003091_abnormal_cell_migration1.18520298
55MP0002139_abnormal_hepatobiliary_system1.15026338
56MP0003828_pulmonary_edema1.13408810
57MP0008469_abnormal_protein_level1.13188209
58MP0001873_stomach_inflammation1.12149470
59MP0003566_abnormal_cell_adhesion1.11873664
60MP0000678_abnormal_parathyroid_gland1.11370128
61MP0003075_altered_response_to1.10754520
62MP0002722_abnormal_immune_system1.09681664
63MP0002429_abnormal_blood_cell1.08044252
64MP0002254_reproductive_system_inflammat1.06599375
65MP0000537_abnormal_urethra_morphology1.05077647
66MP0003656_abnormal_erythrocyte_physiolo1.04324124
67MP0004381_abnormal_hair_follicle1.03769567
68MP0002933_joint_inflammation1.01160234
69MP0003183_abnormal_peptide_metabolism1.00156544
70MP0000703_abnormal_thymus_morphology0.99001679
71MP0003806_abnormal_nucleotide_metabolis0.98250517
72MP0005409_darkened_coat_color0.97299843
73MP0004808_abnormal_hematopoietic_stem0.95888997
74MP0004858_abnormal_nervous_system0.94332675
75MP0000689_abnormal_spleen_morphology0.92052862
76MP0004264_abnormal_extraembryonic_tissu0.91501871
77MP0002796_impaired_skin_barrier0.90932793
78MP0002166_altered_tumor_susceptibility0.90064913
79MP0005360_urolithiasis0.89460939
80MP0000490_abnormal_crypts_of0.88442835
81MP0005375_adipose_tissue_phenotype0.87000038
82MP0005166_decreased_susceptibility_to0.86484668
83MP0005390_skeleton_phenotype0.84740028
84MP0000465_gastrointestinal_hemorrhage0.83720056
85MP0003448_altered_tumor_morphology0.83716559
86MP0005365_abnormal_bile_salt0.83455524
87MP0009764_decreased_sensitivity_to0.76874042
88MP0003795_abnormal_bone_structure0.76505259
89MP0001851_eye_inflammation0.75951724
90MP0000747_muscle_weakness0.75468749
91MP0000767_abnormal_smooth_muscle0.73233305
92MP0008438_abnormal_cutaneous_collagen0.73073231
93MP0005023_abnormal_wound_healing0.71730118
94MP0003690_abnormal_glial_cell0.71363590
95MP0000609_abnormal_liver_physiology0.71157853
96MP0005621_abnormal_cell_physiology0.70126184
97MP0009931_abnormal_skin_appearance0.69928733
98MP0002138_abnormal_hepatobiliary_system0.69621330
99MP0000343_altered_response_to0.68612739
100MP0000604_amyloidosis0.66912776

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.72150912
2Dysostosis multiplex (HP:0000943)3.20137404
3Colitis (HP:0002583)3.14147130
4Abnormality of macrophages (HP:0004311)3.13780909
5Recurrent abscess formation (HP:0002722)2.98301393
6Myositis (HP:0100614)2.94064187
7Deep venous thrombosis (HP:0002625)2.90513229
8Recurrent gram-negative bacterial infections (HP:0005420)2.82613773
9Recurrent bacterial skin infections (HP:0005406)2.80016143
10Thoracic kyphosis (HP:0002942)2.78029478
11Thin bony cortex (HP:0002753)2.75423396
12Increased IgE level (HP:0003212)2.75415073
13Urinary glycosaminoglycan excretion (HP:0003541)2.74986460
14Mucopolysacchariduria (HP:0008155)2.74986460
15Hemorrhage of the eye (HP:0011885)2.73824046
16Abnormality of polysaccharide metabolism (HP:0011012)2.68878693
17Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68878693
18Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68878693
19Gastrointestinal inflammation (HP:0004386)2.61492987
20Gastrointestinal infarctions (HP:0005244)2.59112752
21Orchitis (HP:0100796)2.58960558
22Abnormality of liposaccharide metabolism (HP:0010968)2.56526210
23Abnormality of glycosphingolipid metabolism (HP:0004343)2.56526210
24Abnormality of glycolipid metabolism (HP:0010969)2.56526210
25Nuclear cataract (HP:0100018)2.56434466
26Loss of speech (HP:0002371)2.55984803
27Chronic obstructive pulmonary disease (HP:0006510)2.55746750
28Obstructive lung disease (HP:0006536)2.55746750
29Abnormality of the thoracic spine (HP:0100711)2.54065814
30Systemic lupus erythematosus (HP:0002725)2.48512932
31Mediastinal lymphadenopathy (HP:0100721)2.46597324
32Inflammation of the large intestine (HP:0002037)2.41888124
33Cellulitis (HP:0100658)2.35885953
34Cervical subluxation (HP:0003308)2.35851087
35Metaphyseal cupping (HP:0003021)2.32937276
36Cerebral aneurysm (HP:0004944)2.31043859
37Broad face (HP:0000283)2.30678403
38Granulocytopenia (HP:0001913)2.30562101
39Polygenic inheritance (HP:0010982)2.29345584
40Gingivitis (HP:0000230)2.21137487
41Recurrent viral infections (HP:0004429)2.20745428
42Meningitis (HP:0001287)2.20079052
43Increased cerebral lipofuscin (HP:0011813)2.19175223
44J-shaped sella turcica (HP:0002680)2.19068519
45Optic neuritis (HP:0100653)2.18558486
46Retrobulbar optic neuritis (HP:0100654)2.18558486
47Flat acetabular roof (HP:0003180)2.15081008
48Hypertriglyceridemia (HP:0002155)2.13491775
49Asymmetry of the thorax (HP:0001555)2.11715567
50Increased serum ferritin (HP:0003281)2.11223687
51Recurrent fungal infections (HP:0002841)2.09209270
52Centrally nucleated skeletal muscle fibers (HP:0003687)2.01564370
53Prolonged bleeding time (HP:0003010)2.00651606
54Protrusio acetabuli (HP:0003179)1.97535832
55Abnormality of complement system (HP:0005339)1.97369026
56Abnormality of the columella (HP:0009929)1.97145071
57Obstructive sleep apnea (HP:0002870)1.96379385
58Glomerulonephritis (HP:0000099)1.95779871
59Pustule (HP:0200039)1.95296048
60Abnormality of the lumbar spine (HP:0100712)1.93467324
61Segmental peripheral demyelination/remyelination (HP:0003481)1.92248446
62Vasculitis (HP:0002633)1.91248584
63Purpura (HP:0000979)1.91222418
64Amyloidosis (HP:0011034)1.90419842
65Spontaneous hematomas (HP:0007420)1.90266443
66Biconcave vertebral bodies (HP:0004586)1.87554039
67Spinal cord lesions (HP:0100561)1.86518100
68Syringomyelia (HP:0003396)1.86518100
69Peritonitis (HP:0002586)1.84690380
70Hepatosplenomegaly (HP:0001433)1.83726347
71Axonal loss (HP:0003447)1.83349384
72Slow saccadic eye movements (HP:0000514)1.83105681
73Easy fatigability (HP:0003388)1.83059030
74Thrombocytosis (HP:0001894)1.82665860
75Epistaxis (HP:0000421)1.81330481
76Hyperacusis (HP:0010780)1.80850009
77Abnormality of the fingertips (HP:0001211)1.80633195
78Interstitial pulmonary disease (HP:0006530)1.80197702
79Vertebral compression fractures (HP:0002953)1.79629584
80Elevated alkaline phosphatase (HP:0003155)1.78260921
81Increased neuronal autofluorescent lipopigment (HP:0002074)1.78199252
82Joint stiffness (HP:0001387)1.76933441
83Restrictive lung disease (HP:0002091)1.76871357
84Asymmetric septal hypertrophy (HP:0001670)1.75590394
85Emphysema (HP:0002097)1.75008644
86Elevated erythrocyte sedimentation rate (HP:0003565)1.74827288
87Arterial thrombosis (HP:0004420)1.73863383
88Premature rupture of membranes (HP:0001788)1.73442859
89Viral hepatitis (HP:0006562)1.72394823
90Complement deficiency (HP:0004431)1.72229857
91Recurrent skin infections (HP:0001581)1.71802464
92Aneurysm (HP:0002617)1.71333084
93Chest pain (HP:0100749)1.70712335
94Malnutrition (HP:0004395)1.70006366
95Abnormality of the peritoneum (HP:0002585)1.68683403
96Dilatation of the ascending aorta (HP:0005111)1.67026576
97Blue sclerae (HP:0000592)1.66734610
98Pulmonary embolism (HP:0002204)1.66650950
99Hemoptysis (HP:0002105)1.65959453
100Stridor (HP:0010307)1.65776993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.48761483
2ERN13.63970827
3PRPF4B2.69331114
4RIPK42.66829763
5SIK12.54344798
6NME22.52049886
7SMG12.49706220
8MAP4K12.35592706
9IRAK32.21885251
10FGFR42.16254455
11MAP2K32.13942851
12ICK2.02887397
13TYK22.00128099
14EEF2K1.98586649
15PKN21.89602740
16MAP3K141.88075844
17TNK21.82340684
18MAP3K131.79314832
19RIPK11.70629268
20IRAK41.64308053
21MARK31.60725466
22MAP3K101.59542658
23CDK121.58786095
24BLK1.55580354
25TAOK11.55375401
26TBK11.50601666
27ZAP701.49280466
28CDC42BPA1.47918118
29MATK1.44360643
30MAP3K31.35140020
31CSK1.33622525
32FGR1.28978033
33SIK21.23334384
34GRK61.23026154
35SIK31.21997827
36MAP3K11.19946266
37IRAK21.19817416
38MARK21.19150813
39PTK61.18558347
40BTK1.09138881
41PDGFRA1.09122505
42TAOK21.08042273
43EPHB11.03960481
44JAK31.00875297
45DDR20.93697100
46FES0.91287104
47PDPK10.90184809
48HCK0.87542993
49PRKD20.86732429
50MST1R0.85466083
51MAP3K60.84911345
52MTOR0.84637190
53PAK40.83911020
54KSR20.83451158
55MAP3K110.80075532
56NEK20.77284368
57CSF1R0.74929755
58FGFR30.74426134
59RET0.71261149
60IKBKE0.70991333
61RPS6KL10.70722120
62RPS6KC10.70722120
63BMX0.70392053
64JAK10.68417952
65CDK40.67916169
66MAP3K70.65755976
67PRKG20.63011881
68TESK10.62972532
69RPS6KA20.62634619
70HIPK20.61125949
71TYRO30.59904543
72PDK10.59865767
73JAK20.58482352
74MAP2K60.57652217
75LRRK20.54591526
76MAPK120.54483179
77LYN0.52078789
78MAPK110.51972846
79SYK0.49946044
80TTN0.49633438
81KIT0.46899309
82LCK0.46544214
83RPS6KA60.45894132
84MOS0.45857730
85PDGFRB0.43338827
86MAP3K80.43303864
87STK380.41763772
88LATS20.41019433
89IKBKB0.40981847
90TESK20.39823082
91MELK0.39360308
92CDK60.39019531
93RPS6KA10.35927547
94MAPKAPK20.34909015
95ITK0.34556032
96MAP2K20.33752483
97CDK70.32212955
98MAPK70.31714802
99PTK20.30629931
100IRAK10.29744241

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.97488745
2Osteoclast differentiation_Homo sapiens_hsa043802.30195167
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.28703405
4B cell receptor signaling pathway_Homo sapiens_hsa046622.16088802
5Acute myeloid leukemia_Homo sapiens_hsa052212.13978660
6Leishmaniasis_Homo sapiens_hsa051401.92286957
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89212254
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86205785
9Staphylococcus aureus infection_Homo sapiens_hsa051501.80709582
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.66790569
11Chronic myeloid leukemia_Homo sapiens_hsa052201.59157171
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58969379
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57311769
14Notch signaling pathway_Homo sapiens_hsa043301.57153691
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.53579246
16TNF signaling pathway_Homo sapiens_hsa046681.47971984
17Non-small cell lung cancer_Homo sapiens_hsa052231.46492433
18Tuberculosis_Homo sapiens_hsa051521.45728069
19VEGF signaling pathway_Homo sapiens_hsa043701.44997625
20Influenza A_Homo sapiens_hsa051641.34424458
21Hepatitis C_Homo sapiens_hsa051601.32010593
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30536678
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28889433
24Toxoplasmosis_Homo sapiens_hsa051451.28606074
25T cell receptor signaling pathway_Homo sapiens_hsa046601.27515523
26Lysosome_Homo sapiens_hsa041421.26299874
27Hepatitis B_Homo sapiens_hsa051611.23484316
28Herpes simplex infection_Homo sapiens_hsa051681.23135068
29Bladder cancer_Homo sapiens_hsa052191.22952224
30Malaria_Homo sapiens_hsa051441.20749939
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19998838
32Pertussis_Homo sapiens_hsa051331.19939183
33Apoptosis_Homo sapiens_hsa042101.18428256
34Pancreatic cancer_Homo sapiens_hsa052121.18005757
35Endometrial cancer_Homo sapiens_hsa052131.16819244
36Measles_Homo sapiens_hsa051621.12990833
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10422131
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.03909503
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03891126
40Leukocyte transendothelial migration_Homo sapiens_hsa046700.98308841
41mTOR signaling pathway_Homo sapiens_hsa041500.98176583
42Allograft rejection_Homo sapiens_hsa053300.97563780
43Amoebiasis_Homo sapiens_hsa051460.96298597
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.94585525
45Adipocytokine signaling pathway_Homo sapiens_hsa049200.93808339
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93787503
47Choline metabolism in cancer_Homo sapiens_hsa052310.92828180
48Legionellosis_Homo sapiens_hsa051340.92194046
49Complement and coagulation cascades_Homo sapiens_hsa046100.91881127
50Chemokine signaling pathway_Homo sapiens_hsa040620.91408777
51Insulin signaling pathway_Homo sapiens_hsa049100.90415906
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89758262
53Graft-versus-host disease_Homo sapiens_hsa053320.89016482
54Prostate cancer_Homo sapiens_hsa052150.87506349
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.86725432
56Prion diseases_Homo sapiens_hsa050200.85830695
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.85808926
58GnRH signaling pathway_Homo sapiens_hsa049120.84969894
59Prolactin signaling pathway_Homo sapiens_hsa049170.84663559
60Phagosome_Homo sapiens_hsa041450.84555763
61Fructose and mannose metabolism_Homo sapiens_hsa000510.83747641
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.83225471
63Insulin resistance_Homo sapiens_hsa049310.82698706
64Platelet activation_Homo sapiens_hsa046110.82397648
65African trypanosomiasis_Homo sapiens_hsa051430.79993443
66Shigellosis_Homo sapiens_hsa051310.79631741
67Salmonella infection_Homo sapiens_hsa051320.79087185
68Autoimmune thyroid disease_Homo sapiens_hsa053200.78868725
69Hematopoietic cell lineage_Homo sapiens_hsa046400.78672815
70Primary immunodeficiency_Homo sapiens_hsa053400.77646716
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74086681
72Pentose phosphate pathway_Homo sapiens_hsa000300.72654714
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72457735
74HTLV-I infection_Homo sapiens_hsa051660.71470274
75Estrogen signaling pathway_Homo sapiens_hsa049150.70859032
76Antigen processing and presentation_Homo sapiens_hsa046120.69832325
77Glioma_Homo sapiens_hsa052140.68434521
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67641622
79Renal cell carcinoma_Homo sapiens_hsa052110.66711072
80Thyroid cancer_Homo sapiens_hsa052160.65181700
81Viral myocarditis_Homo sapiens_hsa054160.65110077
82Small cell lung cancer_Homo sapiens_hsa052220.63538350
83Viral carcinogenesis_Homo sapiens_hsa052030.62879699
84ErbB signaling pathway_Homo sapiens_hsa040120.62077089
85Galactose metabolism_Homo sapiens_hsa000520.58007798
86Endocytosis_Homo sapiens_hsa041440.57125914
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.55985675
88FoxO signaling pathway_Homo sapiens_hsa040680.55108176
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54151351
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53867605
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.53788479
92Colorectal cancer_Homo sapiens_hsa052100.53517177
93AMPK signaling pathway_Homo sapiens_hsa041520.53502611
94Proteoglycans in cancer_Homo sapiens_hsa052050.53165640
95HIF-1 signaling pathway_Homo sapiens_hsa040660.52702642
96PPAR signaling pathway_Homo sapiens_hsa033200.52615319
97Focal adhesion_Homo sapiens_hsa045100.50834666
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50505674
99Epstein-Barr virus infection_Homo sapiens_hsa051690.49858406
100Inositol phosphate metabolism_Homo sapiens_hsa005620.46496819

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