CDK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein retention in ER lumen (GO:0006621)5.76325041
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.60207554
3DNA unwinding involved in DNA replication (GO:0006268)5.55467936
4DNA strand elongation involved in DNA replication (GO:0006271)5.26716953
5DNA strand elongation (GO:0022616)5.00756377
6Golgi transport vesicle coating (GO:0048200)4.93971639
7COPI coating of Golgi vesicle (GO:0048205)4.93971639
8telomere maintenance via semi-conservative replication (GO:0032201)4.83868252
9DNA replication initiation (GO:0006270)4.73746512
10ribosomal small subunit assembly (GO:0000028)4.68074663
11nuclear pore complex assembly (GO:0051292)4.27076934
12viral transcription (GO:0019083)4.24271919
13telomere maintenance via recombination (GO:0000722)4.24196579
14translational termination (GO:0006415)4.15425063
15protein localization to kinetochore (GO:0034501)4.14588262
16formation of translation preinitiation complex (GO:0001731)4.13894467
17mitotic recombination (GO:0006312)4.12307446
18protein maturation by protein folding (GO:0022417)3.98725512
19maturation of SSU-rRNA (GO:0030490)3.97396873
20DNA replication-dependent nucleosome assembly (GO:0006335)3.94009981
21DNA replication-dependent nucleosome organization (GO:0034723)3.94009981
22L-serine metabolic process (GO:0006563)3.94008328
23nucleobase biosynthetic process (GO:0046112)3.91792580
24DNA replication checkpoint (GO:0000076)3.86964702
25translational elongation (GO:0006414)3.84467328
26regulation of translational fidelity (GO:0006450)3.83375618
27telomere maintenance via telomere lengthening (GO:0010833)3.83222654
28DNA deamination (GO:0045006)3.79978263
29nucleotide-excision repair, DNA gap filling (GO:0006297)3.76260998
30IMP biosynthetic process (GO:0006188)3.74625680
31proline biosynthetic process (GO:0006561)3.73280687
32negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.69725634
33establishment of viral latency (GO:0019043)3.67914150
34peptidyl-arginine omega-N-methylation (GO:0035247)3.67010056
35translational initiation (GO:0006413)3.66637655
36folic acid-containing compound biosynthetic process (GO:0009396)3.64314535
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.60496800
38mitotic nuclear envelope disassembly (GO:0007077)3.59750733
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.58217582
40CENP-A containing nucleosome assembly (GO:0034080)3.56783745
41ribosomal small subunit biogenesis (GO:0042274)3.56758776
42purine nucleobase biosynthetic process (GO:0009113)3.52499131
43negative regulation of RNA splicing (GO:0033119)3.52202616
44nucleobase-containing small molecule interconversion (GO:0015949)3.51300911
45chromatin remodeling at centromere (GO:0031055)3.49928814
46cotranslational protein targeting to membrane (GO:0006613)3.49394554
47protein targeting to ER (GO:0045047)3.48793342
48ribosomal large subunit biogenesis (GO:0042273)3.47427559
49protein localization to chromosome, centromeric region (GO:0071459)3.46791077
50tRNA methylation (GO:0030488)3.45005915
51mitotic metaphase plate congression (GO:0007080)3.44677900
52heterochromatin organization (GO:0070828)3.43593943
53DNA replication-independent nucleosome assembly (GO:0006336)3.43440401
54DNA replication-independent nucleosome organization (GO:0034724)3.43440401
55deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.39558264
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.38470046
57spliceosomal snRNP assembly (GO:0000387)3.37330523
58pore complex assembly (GO:0046931)3.35947863
59establishment of integrated proviral latency (GO:0075713)3.34937171
60membrane disassembly (GO:0030397)3.30430463
61nuclear envelope disassembly (GO:0051081)3.30430463
62viral life cycle (GO:0019058)3.29908154
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29344521
64cellular protein complex disassembly (GO:0043624)3.27776918
65kinetochore organization (GO:0051383)3.26291929
66ribonucleoprotein complex biogenesis (GO:0022613)3.26159660
67regulation of mitochondrial translation (GO:0070129)3.25588070
68IMP metabolic process (GO:0046040)3.24324200
69protein localization to endoplasmic reticulum (GO:0070972)3.23621271
70DNA duplex unwinding (GO:0032508)3.21377833
71regulation of mammary gland epithelial cell proliferation (GO:0033599)3.20667754
72DNA geometric change (GO:0032392)3.19476806
73negative regulation of mRNA processing (GO:0050686)3.12077777
74ribosome biogenesis (GO:0042254)3.11468904
75protein complex disassembly (GO:0043241)3.10263557
76nuclear pore organization (GO:0006999)3.09893544
77RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.09185433
78mRNA splicing, via spliceosome (GO:0000398)3.09185433
79pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.08576244
80viral mRNA export from host cell nucleus (GO:0046784)3.08447979
81metaphase plate congression (GO:0051310)3.07726368
82histone arginine methylation (GO:0034969)3.07189454
83translesion synthesis (GO:0019985)3.07104992
84RNA splicing, via transesterification reactions (GO:0000375)3.06967265
85DNA topological change (GO:0006265)3.03325189
86spliceosomal complex assembly (GO:0000245)3.02993500
87pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.01334028
88mitotic chromosome condensation (GO:0007076)3.00443134
89peptidyl-arginine N-methylation (GO:0035246)2.99104304
90peptidyl-arginine methylation (GO:0018216)2.99104304
91mitotic sister chromatid segregation (GO:0000070)2.96746769
92nuclear-transcribed mRNA catabolic process (GO:0000956)2.96126423
93transcription-coupled nucleotide-excision repair (GO:0006283)2.95658425
94rRNA processing (GO:0006364)2.94039994
95termination of RNA polymerase II transcription (GO:0006369)2.93006928
96macromolecular complex disassembly (GO:0032984)2.92909011
97regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.92894772
98regulation of translational termination (GO:0006449)2.92737840
99postreplication repair (GO:0006301)2.92320940
100tRNA aminoacylation for protein translation (GO:0006418)2.91670640
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.91624847
102negative regulation of ligase activity (GO:0051352)2.91624847
103sister chromatid segregation (GO:0000819)2.91042493
104paraxial mesoderm development (GO:0048339)2.90997602
105kinetochore assembly (GO:0051382)2.90683669
106histone exchange (GO:0043486)2.90479751
107muscle cell fate commitment (GO:0042693)2.90344839
108base-excision repair (GO:0006284)2.90166373
109regulation of spindle organization (GO:0090224)2.89334346
110ribosome assembly (GO:0042255)2.88417794
111negative regulation of chromosome segregation (GO:0051985)2.88413574
112histone H2A acetylation (GO:0043968)2.88284373
113protein complex localization (GO:0031503)2.88228869
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.87906656
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87906656
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87906656
117negative regulation of sister chromatid segregation (GO:0033046)2.87906656
118negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86634896
119telomere organization (GO:0032200)2.86164668
120telomere maintenance (GO:0000723)2.86065688
121anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84886451
122spindle assembly checkpoint (GO:0071173)2.84027507
123translation (GO:0006412)2.83856447
124mismatch repair (GO:0006298)2.83717343
125chromatin assembly or disassembly (GO:0006333)2.83415312
126mitotic spindle assembly checkpoint (GO:0007094)2.83307272
127somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83296414
128somatic hypermutation of immunoglobulin genes (GO:0016446)2.83296414
129rRNA metabolic process (GO:0016072)2.83143875
130regulation of mitotic spindle organization (GO:0060236)2.82996110
131regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82977745
132amino acid activation (GO:0043038)2.82135041
133tRNA aminoacylation (GO:0043039)2.82135041
134nuclear envelope reassembly (GO:0031468)2.81684413
135mitotic nuclear envelope reassembly (GO:0007084)2.81684413
136pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.81229019
137rRNA transcription (GO:0009303)2.80943143
138spliceosomal tri-snRNP complex assembly (GO:0000244)2.80660833
139chromosome condensation (GO:0030261)2.77460716
140deoxyribonucleotide biosynthetic process (GO:0009263)2.74097662
141proteasome assembly (GO:0043248)2.74025135
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69842775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.09838591
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.45678969
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.95130914
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.91542647
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62680040
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15849516
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03145811
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85079036
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85059314
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84056811
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.76990452
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.59197272
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.59190661
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56408014
15* XRN2_22483619_ChIP-Seq_HELA_Human2.53213269
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52160740
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42327536
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42018653
19AR_21909140_ChIP-Seq_LNCAP_Human2.14268300
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12473752
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10143856
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05351366
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04372427
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04133901
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.98473398
26VDR_23849224_ChIP-Seq_CD4+_Human1.97949270
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96988577
28DCP1A_22483619_ChIP-Seq_HELA_Human1.95437972
29TTF2_22483619_ChIP-Seq_HELA_Human1.93952730
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88366150
31FOXP3_21729870_ChIP-Seq_TREG_Human1.86407245
32ZNF263_19887448_ChIP-Seq_K562_Human1.84894028
33GABP_19822575_ChIP-Seq_HepG2_Human1.82876674
34MYC_22102868_ChIP-Seq_BL_Human1.82269839
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79059721
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78819767
37CIITA_25753668_ChIP-Seq_RAJI_Human1.78097529
38* EGR1_19374776_ChIP-ChIP_THP-1_Human1.72992851
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72770207
40* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71558535
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69489304
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67114086
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65851784
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62654092
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62287294
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.60504297
47* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59409561
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57399261
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54315738
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50564904
51ELK1_19687146_ChIP-ChIP_HELA_Human1.49486862
52* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49080347
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45413000
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44699325
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40040069
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39621270
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.38096278
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37998162
59* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36809156
60* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34322530
61KDM5A_27292631_Chip-Seq_BREAST_Human1.32530411
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32090046
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27957400
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26649136
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25882966
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25828103
67* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25662989
68VDR_21846776_ChIP-Seq_THP-1_Human1.23279369
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.21447178
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17972029
71* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17300235
72* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16556716
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16417236
74* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13829175
75* TFEB_21752829_ChIP-Seq_HELA_Human1.13733543
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12144964
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.10866105
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09434483
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09095072
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06681444
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06380402
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06201298
83* TET1_21451524_ChIP-Seq_MESCs_Mouse1.04917570
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04797231
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04731166
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04408921
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03240661
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01642653
89RACK7_27058665_Chip-Seq_MCF-7_Human1.00980622
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00920679
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00588708
92CLOCK_20551151_ChIP-Seq_293T_Human1.00304931
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00101942
94* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00071079
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99770113
96CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98522913
97TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98340174
98TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96853082
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96553762
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.95348831
101TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94942051
102* ATF3_27146783_Chip-Seq_COLON_Human0.91940894
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91429098
104SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91122480
105MYC_18940864_ChIP-ChIP_HL60_Human0.90530307
106NANOG_21062744_ChIP-ChIP_HESCs_Human0.90432173
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90273366
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90220233
109* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89671959
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89224980
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88780106
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88767998
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88540479
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.87933330
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87592132
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87248482
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86317220
118ELK1_22589737_ChIP-Seq_MCF10A_Human0.85782916
119OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85714922
120SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84422930

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.34524984
2MP0002877_abnormal_melanocyte_morpholog4.07778735
3MP0010094_abnormal_chromosome_stability3.98597536
4MP0004957_abnormal_blastocyst_morpholog3.88960643
5MP0003111_abnormal_nucleus_morphology3.70898525
6* MP0003077_abnormal_cell_cycle3.46324849
7MP0008057_abnormal_DNA_replication3.09537863
8MP0010030_abnormal_orbit_morphology2.87814970
9MP0008058_abnormal_DNA_repair2.72884414
10MP0008932_abnormal_embryonic_tissue2.64413478
11MP0004858_abnormal_nervous_system2.61869328
12MP0003123_paternal_imprinting2.52261254
13* MP0008007_abnormal_cellular_replicative2.48654728
14MP0001346_abnormal_lacrimal_gland2.23078310
15MP0005257_abnormal_intraocular_pressure2.20551704
16MP0001730_embryonic_growth_arrest2.17778827
17MP0010352_gastrointestinal_tract_polyps2.15955423
18MP0002396_abnormal_hematopoietic_system2.08850533
19* MP0000350_abnormal_cell_proliferation2.05222901
20MP0000537_abnormal_urethra_morphology1.97865923
21MP0005623_abnormal_meninges_morphology1.96555692
22MP0006054_spinal_hemorrhage1.84363257
23MP0009053_abnormal_anal_canal1.75892814
24MP0004233_abnormal_muscle_weight1.70185032
25MP0000490_abnormal_crypts_of1.67803770
26* MP0001697_abnormal_embryo_size1.67285692
27MP0002085_abnormal_embryonic_tissue1.67015366
28MP0005380_embryogenesis_phenotype1.64687504
29MP0001672_abnormal_embryogenesis/_devel1.64687504
30MP0001293_anophthalmia1.60795765
31MP0000750_abnormal_muscle_regeneration1.58366675
32MP0002084_abnormal_developmental_patter1.56075274
33MP0003121_genomic_imprinting1.55760655
34* MP0002080_prenatal_lethality1.54366272
35MP0004197_abnormal_fetal_growth/weight/1.54131376
36MP0003984_embryonic_growth_retardation1.52106054
37MP0002088_abnormal_embryonic_growth/wei1.49343112
38MP0002653_abnormal_ependyma_morphology1.46784611
39MP0003567_abnormal_fetal_cardiomyocyte1.46709918
40MP0003786_premature_aging1.44646801
41MP0009697_abnormal_copulation1.44620564
42MP0010307_abnormal_tumor_latency1.42632228
43MP0003315_abnormal_perineum_morphology1.42303973
44MP0002938_white_spotting1.42141350
45MP0000049_abnormal_middle_ear1.38110872
46MP0005501_abnormal_skin_physiology1.36966801
47MP0003806_abnormal_nucleotide_metabolis1.34082931
48MP0000313_abnormal_cell_death1.33495151
49MP0005451_abnormal_body_composition1.33354455
50MP0003119_abnormal_digestive_system1.33133842
51MP0005058_abnormal_lysosome_morphology1.33106412
52MP0004133_heterotaxia1.32303869
53MP0002086_abnormal_extraembryonic_tissu1.30526177
54MP0005171_absent_coat_pigmentation1.28881677
55MP0003186_abnormal_redox_activity1.26580246
56* MP0004808_abnormal_hematopoietic_stem1.26032318
57MP0003890_abnormal_embryonic-extraembry1.25742949
58MP0000462_abnormal_digestive_system1.20684070
59MP0003705_abnormal_hypodermis_morpholog1.19934040
60MP0005076_abnormal_cell_differentiation1.19501436
61* MP0002019_abnormal_tumor_incidence1.16156229
62MP0002111_abnormal_tail_morphology1.15904486
63MP0001188_hyperpigmentation1.15231047
64MP0000566_synostosis1.14877847
65MP0009379_abnormal_foot_pigmentation1.14084600
66MP0003942_abnormal_urinary_system1.13935093
67MP0004272_abnormal_basement_membrane1.13223416
68MP0000428_abnormal_craniofacial_morphol1.11539737
69MP0005197_abnormal_uvea_morphology1.10681501
70MP0003937_abnormal_limbs/digits/tail_de1.10395713
71MP0002932_abnormal_joint_morphology1.08890809
72MP0002282_abnormal_trachea_morphology1.07466885
73MP0002060_abnormal_skin_morphology1.07095504
74MP0000762_abnormal_tongue_morphology1.03338029
75MP0003115_abnormal_respiratory_system1.03198212
76MP0009333_abnormal_splenocyte_physiolog1.01645304
77MP0003122_maternal_imprinting1.00348728
78MP0004185_abnormal_adipocyte_glucose0.98363750
79MP0001545_abnormal_hematopoietic_system0.98150517
80MP0005397_hematopoietic_system_phenotyp0.98150517
81MP0006292_abnormal_olfactory_placode0.97421594
82MP0002092_abnormal_eye_morphology0.96037294
83MP0002249_abnormal_larynx_morphology0.96025921
84MP0003385_abnormal_body_wall0.95067346
85MP0008438_abnormal_cutaneous_collagen0.94770081
86MP0009278_abnormal_bone_marrow0.94429630
87MP0008877_abnormal_DNA_methylation0.94428765
88MP0003283_abnormal_digestive_organ0.92868324
89MP0005408_hypopigmentation0.92624361
90MP0003566_abnormal_cell_adhesion0.92585129
91MP0003941_abnormal_skin_development0.92291360
92MP0000703_abnormal_thymus_morphology0.92112274
93MP0001286_abnormal_eye_development0.91076117
94MP0001661_extended_life_span0.89492992
95MP0000858_altered_metastatic_potential0.88785042
96MP0000534_abnormal_ureter_morphology0.88234822
97MP0001186_pigmentation_phenotype0.87645250
98MP0000733_abnormal_muscle_development0.87608093
99MP0005384_cellular_phenotype0.87326976
100MP0005023_abnormal_wound_healing0.86861694
101MP0001849_ear_inflammation0.86599683
102MP0003935_abnormal_craniofacial_develop0.85596522
103MP0009672_abnormal_birth_weight0.84923602
104MP0008789_abnormal_olfactory_epithelium0.83961704
105MP0005621_abnormal_cell_physiology0.83351876
106MP0002697_abnormal_eye_size0.83065659
107MP0001915_intracranial_hemorrhage0.82653954
108MP0000678_abnormal_parathyroid_gland0.82515632
109MP0002751_abnormal_autonomic_nervous0.81508939
110MP0006035_abnormal_mitochondrial_morpho0.81069009
111MP0001299_abnormal_eye_distance/0.81039133
112MP0002108_abnormal_muscle_morphology0.80614095
113MP0001727_abnormal_embryo_implantation0.78526252
114MP0002075_abnormal_coat/hair_pigmentati0.77340162
115* MP0002210_abnormal_sex_determination0.77226192
116MP0003718_maternal_effect0.76946139
117MP0002796_impaired_skin_barrier0.76494482
118MP0005503_abnormal_tendon_morphology0.76385594
119MP0003763_abnormal_thymus_physiology0.75996704
120MP0008260_abnormal_autophagy0.75644341
121MP0002160_abnormal_reproductive_system0.74389922
122MP0000432_abnormal_head_morphology0.73756956
123MP0002114_abnormal_axial_skeleton0.73541176
124MP0009250_abnormal_appendicular_skeleto0.73333747
125MP0002116_abnormal_craniofacial_bone0.73151478
126MP0000358_abnormal_cell_content/0.72694946
127MP0003755_abnormal_palate_morphology0.72685022
128* MP0001145_abnormal_male_reproductive0.71044806
129MP0001881_abnormal_mammary_gland0.70234540
130MP0002102_abnormal_ear_morphology0.70013952
131MP0000759_abnormal_skeletal_muscle0.69964959
132MP0000477_abnormal_intestine_morphology0.69806205
133MP0002089_abnormal_postnatal_growth/wei0.68375975
134MP0005508_abnormal_skeleton_morphology0.68016898
135MP0002722_abnormal_immune_system0.67051684
136MP0002398_abnormal_bone_marrow0.66975255
137MP0003861_abnormal_nervous_system0.66468532
138MP0002925_abnormal_cardiovascular_devel0.65312402

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.31353752
2Premature rupture of membranes (HP:0001788)4.15962484
3Colon cancer (HP:0003003)3.92274336
4Abnormality of cells of the erythroid lineage (HP:0012130)3.79336044
5Birth length less than 3rd percentile (HP:0003561)3.75979429
6Selective tooth agenesis (HP:0001592)3.72958106
7Abnormal number of erythroid precursors (HP:0012131)3.66749535
8Vertebral compression fractures (HP:0002953)3.32815038
9Progressive muscle weakness (HP:0003323)3.17752385
10Patent foramen ovale (HP:0001655)3.17246944
11Oral leukoplakia (HP:0002745)3.13053869
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.12517568
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.12517568
14Patellar aplasia (HP:0006443)3.10268201
15Medulloblastoma (HP:0002885)3.10147981
16Aplastic anemia (HP:0001915)3.07977640
17Abnormality of the umbilical cord (HP:0010881)3.04803531
18Microvesicular hepatic steatosis (HP:0001414)3.01756694
19Degeneration of anterior horn cells (HP:0002398)2.94882648
20Abnormality of the anterior horn cell (HP:0006802)2.94882648
21Abnormal number of incisors (HP:0011064)2.94635269
22Aplasia/Hypoplasia of the patella (HP:0006498)2.92907069
23Breast hypoplasia (HP:0003187)2.90542397
24Ependymoma (HP:0002888)2.88925530
2511 pairs of ribs (HP:0000878)2.77575953
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.74508572
27Short 4th metacarpal (HP:0010044)2.74508572
28Abnormal umbilical cord blood vessels (HP:0011403)2.69876049
29Single umbilical artery (HP:0001195)2.69876049
30Abnormality of the fetal cardiovascular system (HP:0010948)2.69876049
31Microretrognathia (HP:0000308)2.59467657
32Chromsome breakage (HP:0040012)2.59196586
33Meckel diverticulum (HP:0002245)2.55812828
34Renal duplication (HP:0000075)2.53036434
35Pallor (HP:0000980)2.52385796
36Abnormality of the ileum (HP:0001549)2.48936306
37Trismus (HP:0000211)2.48754815
38Macrocytic anemia (HP:0001972)2.48409194
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47356240
40Atresia of the external auditory canal (HP:0000413)2.46065274
41Insomnia (HP:0100785)2.44043661
42Increased nuchal translucency (HP:0010880)2.42908873
43Abnormal lung lobation (HP:0002101)2.37430617
44Abnormality of glycolysis (HP:0004366)2.37003341
45Broad distal phalanx of finger (HP:0009836)2.35903571
46Rough bone trabeculation (HP:0100670)2.33105330
47Abnormalities of placenta or umbilical cord (HP:0001194)2.32150738
48Proximal placement of thumb (HP:0009623)2.31636828
49Protrusio acetabuli (HP:0003179)2.26327327
50Missing ribs (HP:0000921)2.25417296
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.24731154
52Deviation of the thumb (HP:0009603)2.24609883
53Small intestinal stenosis (HP:0012848)2.20932331
54Duodenal stenosis (HP:0100867)2.20932331
55Overriding aorta (HP:0002623)2.19784729
56Increased serum pyruvate (HP:0003542)2.19547455
57Abnormality of chromosome stability (HP:0003220)2.19281229
58Slender long bone (HP:0003100)2.19107242
59Premature graying of hair (HP:0002216)2.18614560
60* Neoplasm of the pancreas (HP:0002894)2.17270362
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17058652
62Agnosia (HP:0010524)2.14945518
63Absent thumb (HP:0009777)2.13886475
64Abnormality of the preputium (HP:0100587)2.13823339
65Abnormality of dentin (HP:0010299)2.13633072
66Rhabdomyosarcoma (HP:0002859)2.11700022
67Tracheoesophageal fistula (HP:0002575)2.07785512
68Absent radius (HP:0003974)2.07226794
69Optic nerve coloboma (HP:0000588)2.06416006
70Myelodysplasia (HP:0002863)2.05402513
71Microglossia (HP:0000171)2.05014064
72Multiple enchondromatosis (HP:0005701)2.04921840
73Triphalangeal thumb (HP:0001199)2.04891464
74Glossoptosis (HP:0000162)2.02253880
75Bladder diverticulum (HP:0000015)2.02092550
76Thrombocytosis (HP:0001894)2.00397637
77Generalized amyotrophy (HP:0003700)1.99471435
78Ragged-red muscle fibers (HP:0003200)1.98845180
79Carpal bone hypoplasia (HP:0001498)1.98809156
80Aplasia/Hypoplasia of the sternum (HP:0006714)1.98392112
81Elfin facies (HP:0004428)1.97306389
82Abnormality of the 4th metacarpal (HP:0010012)1.96987333
83Abnormality of the calcaneus (HP:0008364)1.96587273
84Abnormality of the duodenum (HP:0002246)1.95904086
85Achilles tendon contracture (HP:0001771)1.95177078
86Short middle phalanx of the 5th finger (HP:0004220)1.94007292
87Ectopic kidney (HP:0000086)1.93845230
88Aplasia involving forearm bones (HP:0009822)1.93776044
89Absent forearm bone (HP:0003953)1.93776044
90Ulnar bowing (HP:0003031)1.92673255
91Basal cell carcinoma (HP:0002671)1.91050552
92Hypoplasia of the capital femoral epiphysis (HP:0003090)1.89282434
93Biconcave vertebral bodies (HP:0004586)1.88637305
94Rhabdomyolysis (HP:0003201)1.87269082
95Preauricular skin tag (HP:0000384)1.84927405
96Breech presentation (HP:0001623)1.84131438
97Short 5th finger (HP:0009237)1.82899939
98Supernumerary spleens (HP:0009799)1.81646462
99Abnormality of the astrocytes (HP:0100707)1.80729701
100Astrocytoma (HP:0009592)1.80729701
101Nephroblastoma (Wilms tumor) (HP:0002667)1.80488284
102Sloping forehead (HP:0000340)1.80473891
103Cutaneous melanoma (HP:0012056)1.80207911
104Delayed cranial suture closure (HP:0000270)1.78912493
105Horseshoe kidney (HP:0000085)1.78793735
106Neoplasm of the colon (HP:0100273)1.78653526
107Bone marrow hypocellularity (HP:0005528)1.78091177
108Abnormal trabecular bone morphology (HP:0100671)1.77237931
109Type I transferrin isoform profile (HP:0003642)1.77170232
110Testicular atrophy (HP:0000029)1.76508191
111Abnormality of abdominal situs (HP:0011620)1.74195126
112Abdominal situs inversus (HP:0003363)1.74195126
113Orthostatic hypotension (HP:0001278)1.74130286
114Abnormality of the carotid arteries (HP:0005344)1.73936344
115Neoplasm of head and neck (HP:0012288)1.73372838
116Esophageal neoplasm (HP:0100751)1.73372838
117Neoplasm of striated muscle (HP:0009728)1.73247357
118Embryonal renal neoplasm (HP:0011794)1.73159454
119Abnormality of reticulocytes (HP:0004312)1.73138658
120Fragile skin (HP:0001030)1.72367347
121Squamous cell carcinoma (HP:0002860)1.72313993
122Hypokinesia (HP:0002375)1.72198785
123High pitched voice (HP:0001620)1.71851805
124Cellular immunodeficiency (HP:0005374)1.71433485
125Rib fusion (HP:0000902)1.71359555
126Abnormality of the distal phalanges of the toes (HP:0010182)1.71023914
127Asymmetry of the thorax (HP:0001555)1.71008236
128Facial cleft (HP:0002006)1.70422943
129Calcaneovalgus deformity (HP:0001848)1.70157904
130Long palpebral fissure (HP:0000637)1.70133931
131Cleft eyelid (HP:0000625)1.69841700
132Glioma (HP:0009733)1.69063871
133High anterior hairline (HP:0009890)1.69055767
134Myopathic facies (HP:0002058)1.68732735
135Secondary amenorrhea (HP:0000869)1.68416391
136Skin tags (HP:0010609)1.68177428
137Increased serum lactate (HP:0002151)1.68025890
138Ovarian neoplasm (HP:0100615)1.67951689
139Overlapping toe (HP:0001845)1.67715645
140Pterygium (HP:0001059)1.67708107
141Elbow flexion contracture (HP:0002987)1.67371200
142Cholecystitis (HP:0001082)1.67128778
143Abnormal gallbladder physiology (HP:0012438)1.67128778
144Ankle contracture (HP:0006466)1.66310175
145Patellar dislocation (HP:0002999)1.66250504
146Hyperacusis (HP:0010780)1.65936644
147Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.64793963
148Atrophy/Degeneration involving motor neurons (HP:0007373)1.64637930
149Amaurosis fugax (HP:0100576)1.64549049
150Cerebral hypomyelination (HP:0006808)1.64499048
151Spinal cord lesions (HP:0100561)1.63779014
152Syringomyelia (HP:0003396)1.63779014
153Short thumb (HP:0009778)1.63565760
154Short palpebral fissure (HP:0012745)1.62963017
155Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.60281455
156Absent epiphyses (HP:0010577)1.60281455
157Hypoplasia of the radius (HP:0002984)1.59678001
158Spastic diplegia (HP:0001264)1.56380725
159Spastic paraparesis (HP:0002313)1.56380094
160Abnormality of the Achilles tendon (HP:0005109)1.55159644
161Spinal rigidity (HP:0003306)1.54303951
162Premature skin wrinkling (HP:0100678)1.53311267
163Short nail (HP:0001799)1.52851132
164Unilateral renal agenesis (HP:0000122)1.52799084
165Bowel diverticulosis (HP:0005222)1.52708876
166Amniotic constriction ring (HP:0009775)1.52575219
167Abnormality of placental membranes (HP:0011409)1.52575219
168Death in childhood (HP:0003819)1.50575904

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.22184086
2CDC74.01150411
3VRK24.00223071
4WEE13.78509280
5MOS3.26942431
6SMG13.05846492
7EIF2AK12.83589500
8PASK2.68821808
9IRAK32.61160613
10SRPK12.39949710
11NEK22.38905823
12TESK22.36491512
13TGFBR12.07737124
14ACVR1B2.07309427
15NME22.07013120
16MKNK12.05056758
17TSSK61.97895619
18DYRK31.97055077
19MAP3K101.89833711
20STK161.86384926
21NEK11.84079047
22EEF2K1.83329939
23TTK1.82410409
24PAK41.81813930
25BRSK21.78908571
26RPS6KA41.77642014
27ATR1.72006001
28PLK11.71687640
29TLK11.70281224
30VRK11.68922863
31RPS6KB21.62919441
32AURKB1.60389254
33ICK1.51504405
34TAF11.50555736
35EIF2AK31.46426421
36* CDK71.46021890
37SCYL21.44114893
38PKN21.42710587
39CCNB11.42623253
40MST1R1.41328868
41TESK11.35352558
42PLK41.34549161
43MAP3K81.33264337
44BRSK11.32420179
45FLT31.20744891
46CDK41.20435956
47PLK31.19109508
48CDK121.19047393
49AURKA1.18420714
50CHEK21.16623398
51MKNK21.14122795
52LRRK21.10965463
53CDK81.10419953
54CHEK11.05949528
55KDR1.03281500
56TRIB31.01552789
57STK100.96846036
58LMTK20.96502337
59ARAF0.95399155
60PIM20.90450043
61MET0.89416221
62STK40.88714956
63CDK11A0.88023794
64LIMK10.88008525
65CDK150.85325913
66ERBB40.85014747
67TAOK20.84701768
68FGFR40.83563621
69CDK180.82845001
70ILK0.80976314
71EPHA20.79868423
72BRD40.79518791
73PTK20.77243346
74CSNK1G30.77051148
75CDK140.74734358
76DAPK10.74006871
77ERN10.73940658
78CDK20.73858053
79ATM0.70918399
80PAK10.69715634
81NME10.66936621
82CDK60.66294578
83ABL20.64110950
84CSNK2A10.60769143
85CSNK2A20.60411696
86MAPKAPK30.59847473
87EPHB20.59614766
88MELK0.59506961
89PIM10.59443891
90CSNK1A1L0.57531071
91MAP3K110.57167061
92SIK10.55778989
93CDK10.54970151
94FGFR10.54500019
95CDK90.54486133
96DYRK20.54284953
97AKT20.54054481
98PAK20.53502719
99CLK10.53221360
100DYRK1B0.52706523
101EIF2AK20.50905207
102DAPK30.49739722
103BCKDK0.49441500
104MAP2K30.49274505
105PRPF4B0.49234067
106BTK0.48691584
107PDGFRA0.48622402
108NTRK10.48318167
109CSNK1G10.48111176
110PBK0.46437640
111PDK20.46191685
112ERBB30.45523775
113MAPK110.45523029
114IRAK20.45413128
115MAP2K10.44985492
116MTOR0.43993196
117NEK90.38005013
118PRKCI0.36878809
119RPS6KA50.36399936
120BRAF0.35285199
121MAP4K10.34806093
122ERBB20.33659315
123ZAK0.33619144
124BLK0.30215578
125ALK0.30087442
126TTN0.28368890
127STK30.27482333
128UHMK10.27035938
129PRKDC0.26915756
130LATS20.26678010
131PTK60.25483572
132CSF1R0.23984292
133ZAP700.23894087

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.45019442
2Mismatch repair_Homo sapiens_hsa034304.44740541
3Ribosome_Homo sapiens_hsa030103.68855838
4Spliceosome_Homo sapiens_hsa030403.57050187
5Base excision repair_Homo sapiens_hsa034103.31665106
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97109362
7Homologous recombination_Homo sapiens_hsa034402.95669385
8RNA transport_Homo sapiens_hsa030132.90037268
9Proteasome_Homo sapiens_hsa030502.89218190
10Nucleotide excision repair_Homo sapiens_hsa034202.88861564
11* Cell cycle_Homo sapiens_hsa041102.79471224
12RNA polymerase_Homo sapiens_hsa030202.65996077
13One carbon pool by folate_Homo sapiens_hsa006702.65835904
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40601010
15Pyrimidine metabolism_Homo sapiens_hsa002402.39893128
16Fanconi anemia pathway_Homo sapiens_hsa034601.96154315
17Non-homologous end-joining_Homo sapiens_hsa034501.85796405
18RNA degradation_Homo sapiens_hsa030181.74485066
19mRNA surveillance pathway_Homo sapiens_hsa030151.70752585
20Basal transcription factors_Homo sapiens_hsa030221.53584157
21* p53 signaling pathway_Homo sapiens_hsa041151.45661506
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30423644
23Systemic lupus erythematosus_Homo sapiens_hsa053221.18629688
24Vitamin B6 metabolism_Homo sapiens_hsa007501.18576144
25Fatty acid elongation_Homo sapiens_hsa000621.18096364
26Purine metabolism_Homo sapiens_hsa002301.16030510
27Epstein-Barr virus infection_Homo sapiens_hsa051691.13286193
28Basal cell carcinoma_Homo sapiens_hsa052171.07811896
29Pyruvate metabolism_Homo sapiens_hsa006201.04672927
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95696493
31* Viral carcinogenesis_Homo sapiens_hsa052030.93684305
32Notch signaling pathway_Homo sapiens_hsa043300.93496540
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92558956
34Herpes simplex infection_Homo sapiens_hsa051680.92285027
35Protein export_Homo sapiens_hsa030600.90609092
36* HTLV-I infection_Homo sapiens_hsa051660.89390438
37Oxidative phosphorylation_Homo sapiens_hsa001900.88013390
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87106007
39MicroRNAs in cancer_Homo sapiens_hsa052060.85557838
40Biosynthesis of amino acids_Homo sapiens_hsa012300.85465835
41Thyroid cancer_Homo sapiens_hsa052160.84597295
42Selenocompound metabolism_Homo sapiens_hsa004500.83940229
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82416635
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81371288
45Oocyte meiosis_Homo sapiens_hsa041140.80025275
46Hippo signaling pathway_Homo sapiens_hsa043900.78677694
47Antigen processing and presentation_Homo sapiens_hsa046120.78639864
48N-Glycan biosynthesis_Homo sapiens_hsa005100.75629899
49Sulfur relay system_Homo sapiens_hsa041220.74170480
50Hedgehog signaling pathway_Homo sapiens_hsa043400.72497308
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72285498
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.72243546
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70362497
54Legionellosis_Homo sapiens_hsa051340.70158784
55Vibrio cholerae infection_Homo sapiens_hsa051100.67918334
56* Small cell lung cancer_Homo sapiens_hsa052220.67665442
57Steroid biosynthesis_Homo sapiens_hsa001000.65342102
58TGF-beta signaling pathway_Homo sapiens_hsa043500.65181789
59Folate biosynthesis_Homo sapiens_hsa007900.63504029
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62512862
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62319979
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.61856218
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.61750232
64Pentose phosphate pathway_Homo sapiens_hsa000300.61276196
65Colorectal cancer_Homo sapiens_hsa052100.60988204
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60614813
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60454230
68Arginine and proline metabolism_Homo sapiens_hsa003300.58610870
69* Pancreatic cancer_Homo sapiens_hsa052120.53979906
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52984557
71Shigellosis_Homo sapiens_hsa051310.52317873
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51642713
73Sulfur metabolism_Homo sapiens_hsa009200.50543737
74Alzheimers disease_Homo sapiens_hsa050100.50279538
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49191700
76Apoptosis_Homo sapiens_hsa042100.48945922
77Alcoholism_Homo sapiens_hsa050340.47590260
78Glutathione metabolism_Homo sapiens_hsa004800.47064399
79* Chronic myeloid leukemia_Homo sapiens_hsa052200.46772909
80Carbon metabolism_Homo sapiens_hsa012000.45662539
81* Non-small cell lung cancer_Homo sapiens_hsa052230.45556092
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44473507
83* Melanoma_Homo sapiens_hsa052180.43442005
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.43043563
85Other glycan degradation_Homo sapiens_hsa005110.42452976
86Viral myocarditis_Homo sapiens_hsa054160.42446727
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41615169
88* Pathways in cancer_Homo sapiens_hsa052000.40422014
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40373641
90* Bladder cancer_Homo sapiens_hsa052190.40168147
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39161164
92Adherens junction_Homo sapiens_hsa045200.38150107
93Prion diseases_Homo sapiens_hsa050200.38066778
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35772969
95Wnt signaling pathway_Homo sapiens_hsa043100.33626378
96* Hepatitis B_Homo sapiens_hsa051610.33243874
97Arginine biosynthesis_Homo sapiens_hsa002200.33184459
98Huntingtons disease_Homo sapiens_hsa050160.32640559
99Proteoglycans in cancer_Homo sapiens_hsa052050.31926872
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.31098777
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30854877
102Galactose metabolism_Homo sapiens_hsa000520.30778194
103HIF-1 signaling pathway_Homo sapiens_hsa040660.28740361
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25420216
105* Glioma_Homo sapiens_hsa052140.23911923
106Acute myeloid leukemia_Homo sapiens_hsa052210.23850701
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22804101
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22748060
109* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21313741
110Prostate cancer_Homo sapiens_hsa052150.21223307
111Primary immunodeficiency_Homo sapiens_hsa053400.21054102
112* Measles_Homo sapiens_hsa051620.20905683
113Lysine degradation_Homo sapiens_hsa003100.20291022
114Parkinsons disease_Homo sapiens_hsa050120.20192316
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.17537700
116Renin-angiotensin system_Homo sapiens_hsa046140.16884359
117Influenza A_Homo sapiens_hsa051640.15676978
118Endometrial cancer_Homo sapiens_hsa052130.15006449
119Fructose and mannose metabolism_Homo sapiens_hsa000510.13006513
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.12090233
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.10167960
122Focal adhesion_Homo sapiens_hsa045100.08934396
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.08791865
124Metabolic pathways_Homo sapiens_hsa011000.08615055
125Hematopoietic cell lineage_Homo sapiens_hsa046400.08227775

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