ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.88977474
2	indolalkylamine metabolic process (GO:0006586)	4.77311455
3	photoreceptor cell maintenance (GO:0045494)	4.46221791
4	tachykinin receptor signaling pathway (GO:0007217)	4.42559170
5	behavioral response to ethanol (GO:0048149)	4.21213548
6	response to pheromone (GO:0019236)	4.15300720
7	tryptophan catabolic process (GO:0006569)	4.06993635
8	indole-containing compound catabolic process (GO:0042436)	4.06993635
9	indolalkylamine catabolic process (GO:0046218)	4.06993635
10	righting reflex (GO:0060013)	4.00823166
11	kynurenine metabolic process (GO:0070189)	4.00337896
12	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.98613023
13	tryptophan metabolic process (GO:0006568)	3.97002588
14	proline transport (GO:0015824)	3.94255063
15	signal peptide processing (GO:0006465)	3.92706758
16	cilium or flagellum-dependent cell motility (GO:0001539)	3.84993091
17	reflex (GO:0060004)	3.78964703
18	protein-chromophore linkage (GO:0018298)	3.67237578
19	protein K11-linked deubiquitination (GO:0035871)	3.65494755
20	adaptation of signaling pathway (GO:0023058)	3.62726213
21	detection of light stimulus involved in sensory perception (GO:0050962)	3.52712145
22	detection of light stimulus involved in visual perception (GO:0050908)	3.52712145
23	fucose catabolic process (GO:0019317)	3.47713692
24	L-fucose metabolic process (GO:0042354)	3.47713692
25	L-fucose catabolic process (GO:0042355)	3.47713692
26	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.43272248
27	cellular ketone body metabolic process (GO:0046950)	3.43164777
28	axoneme assembly (GO:0035082)	3.42711453
29	neural tube formation (GO:0001841)	3.38135473
30	glycosphingolipid biosynthetic process (GO:0006688)	3.36971416
31	retinal cone cell development (GO:0046549)	3.34231047
32	neuronal action potential (GO:0019228)	3.34128895
33	behavioral response to nicotine (GO:0035095)	3.31250209
34	indole-containing compound metabolic process (GO:0042430)	3.30290559
35	inositol phosphate catabolic process (GO:0071545)	3.28909313
36	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.24377388
37	piRNA metabolic process (GO:0034587)	3.16915161
38	DNA double-strand break processing (GO:0000729)	3.11323951
39	epithelial cilium movement (GO:0003351)	3.09824565
40	ketone body metabolic process (GO:1902224)	3.09767680
41	protein localization to cilium (GO:0061512)	3.08234017
42	DNA deamination (GO:0045006)	3.07391904
43	positive regulation of developmental pigmentation (GO:0048087)	3.05976042
44	establishment of protein localization to Golgi (GO:0072600)	3.05087410
45	amine catabolic process (GO:0009310)	3.04591616
46	cellular biogenic amine catabolic process (GO:0042402)	3.04591616
47	prenylation (GO:0097354)	3.03934242
48	protein prenylation (GO:0018342)	3.03934242
49	auditory receptor cell stereocilium organization (GO:0060088)	3.01428623
50	mannosylation (GO:0097502)	3.00290568
51	regulation of meiosis I (GO:0060631)	2.93860009
52	startle response (GO:0001964)	2.93600136
53	sphingoid metabolic process (GO:0046519)	2.93134496
54	inner ear receptor stereocilium organization (GO:0060122)	2.90164425
55	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.89460230
56	inositol phosphate dephosphorylation (GO:0046855)	2.89460230
57	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.86866824
58	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.86241353
59	cellular response to sterol (GO:0036315)	2.85957984
60	negative regulation of cAMP-mediated signaling (GO:0043951)	2.85321305
61	cilium movement (GO:0003341)	2.84029553
62	platelet dense granule organization (GO:0060155)	2.83370660
63	dopamine transport (GO:0015872)	2.82576463
64	regulation of sarcomere organization (GO:0060297)	2.81293766
65	regulation of pigment cell differentiation (GO:0050932)	2.79285644
66	cellular response to ATP (GO:0071318)	2.77848550
67	polyol catabolic process (GO:0046174)	2.76310879
68	glycerophospholipid catabolic process (GO:0046475)	2.75351157
69	pyrimidine dimer repair (GO:0006290)	2.74419362
70	positive regulation of glycolytic process (GO:0045821)	2.73122801
71	tyrosine phosphorylation of STAT protein (GO:0007260)	2.72740647
72	benzene-containing compound metabolic process (GO:0042537)	2.71538383
73	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.71355762
74	adenosine metabolic process (GO:0046085)	2.71036632
75	opioid receptor signaling pathway (GO:0038003)	2.69371129
76	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.67073377
77	intraciliary transport (GO:0042073)	2.64721110
78	protein localization to Golgi apparatus (GO:0034067)	2.64357675
79	presynaptic membrane assembly (GO:0097105)	2.60154133
80	cilium morphogenesis (GO:0060271)	2.60108080
81	aromatic amino acid family catabolic process (GO:0009074)	2.58591655
82	cilium organization (GO:0044782)	2.58515618
83	response to nitrosative stress (GO:0051409)	2.56331907
84	thyroid hormone metabolic process (GO:0042403)	2.55112056
85	aromatic amino acid family metabolic process (GO:0009072)	2.54645188
86	phasic smooth muscle contraction (GO:0014821)	2.53382136
87	regulation of hippo signaling (GO:0035330)	2.52046872
88	cilium assembly (GO:0042384)	2.50765630
89	positive regulation of cAMP-mediated signaling (GO:0043950)	2.49538454
90	photoreceptor cell development (GO:0042461)	2.46354683
91	cornea development in camera-type eye (GO:0061303)	2.45479478
92	protein targeting to Golgi (GO:0000042)	2.45190828
93	early endosome to late endosome transport (GO:0045022)	2.42235340
94	DNA methylation involved in gamete generation (GO:0043046)	2.41168402
95	kidney morphogenesis (GO:0060993)	2.40489153
96	preassembly of GPI anchor in ER membrane (GO:0016254)	2.39481843
97	multicellular organism reproduction (GO:0032504)	2.38439425
98	visual perception (GO:0007601)	2.38314576
99	regulation of protein glycosylation (GO:0060049)	2.37285137
100	sensory perception of light stimulus (GO:0050953)	2.36186812

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.83866669
2	VDR_22108803_ChIP-Seq_LS180_Human	3.12376978
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.99600785
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.98787456
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.94312042
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.91250908
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.79758456
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.76625845
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.63107214
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.45379156
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.45280258
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.36833990
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.31072569
14	P300_19829295_ChIP-Seq_ESCs_Human	2.28169066
15	FUS_26573619_Chip-Seq_HEK293_Human	2.17512809
16	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.14524847
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.09016616
18	EZH2_22144423_ChIP-Seq_EOC_Human	2.02261140
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.97506930
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.96721011
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.95541279
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.94486646
23	EWS_26573619_Chip-Seq_HEK293_Human	1.92122334
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.89815308
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87736597
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.80717792
27	STAT3_23295773_ChIP-Seq_U87_Human	1.79585907
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.71573969
29	TCF4_23295773_ChIP-Seq_U87_Human	1.67176676
30	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.67122645
31	AR_25329375_ChIP-Seq_VCAP_Human	1.65041271
32	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.61127398
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.60500311
34	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.59901261
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.59536592
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.59135384
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.59135384
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.58981811
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.58613745
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.58420001
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.56461969
42	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.55703697
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.55143761
44	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.51671527
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.49750442
46	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.49473642
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.45333486
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.42507828
49	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.42386428
50	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40798579
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.40225000
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38752658
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38752658
54	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.34181181
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34181181
56	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.33341481
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31946223
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.31488286
59	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.31285394
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30126328
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.29415845
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27691813
63	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.25091087
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.24515054
65	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.24389847
66	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.23725929
67	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23460091
68	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.23413699
69	AR_21572438_ChIP-Seq_LNCaP_Human	1.21081604
70	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.20138713
71	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.19905309
72	CDX2_22108803_ChIP-Seq_LS180_Human	1.18595382
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17572135
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17371255
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16206728
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15293249
77	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.14835500
78	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.13465086
79	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.12343876
80	KDM2B_26808549_Chip-Seq_REH_Human	1.12321488
81	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.11368452
82	IRF1_19129219_ChIP-ChIP_H3396_Human	1.10785332
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09925676
84	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.09345495
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08418511
86	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.07392914
87	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06310179
88	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.05561576
89	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.04733743
90	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04637119
91	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.02263571
92	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.01658627
93	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01524263
94	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01524263
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01381669
96	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.01027592
97	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.99814317
98	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.99648535
99	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.99371315
100	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.99371315

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.88745941
2	MP0001968_abnormal_touch/_nociception	3.35415381
3	MP0002736_abnormal_nociception_after	3.23910714
4	MP0003880_abnormal_central_pattern	3.03442078
5	MP0008877_abnormal_DNA_methylation	2.99261793
6	MP0003195_calcinosis	2.66812120
7	MP0005551_abnormal_eye_electrophysiolog	2.63466414
8	MP0002837_dystrophic_cardiac_calcinosis	2.57383285
9	MP0002638_abnormal_pupillary_reflex	2.54081271
10	MP0005253_abnormal_eye_physiology	2.50651293
11	MP0006072_abnormal_retinal_apoptosis	2.40188262
12	MP0002876_abnormal_thyroid_physiology	2.35425399
13	MP0008995_early_reproductive_senescence	2.20862552
14	MP0000372_irregular_coat_pigmentation	2.13349567
15	MP0001501_abnormal_sleep_pattern	2.03348543
16	MP0009046_muscle_twitch	1.94621894
17	MP0000569_abnormal_digit_pigmentation	1.94323475
18	MP0002138_abnormal_hepatobiliary_system	1.88656277
19	MP0003646_muscle_fatigue	1.87328603
20	MP0005085_abnormal_gallbladder_physiolo	1.86317828
21	MP0001486_abnormal_startle_reflex	1.86125167
22	MP0003011_delayed_dark_adaptation	1.82370067
23	MP0002254_reproductive_system_inflammat	1.76839731
24	MP0003787_abnormal_imprinting	1.76652455
25	MP0001984_abnormal_olfaction	1.73253466
26	MP0001986_abnormal_taste_sensitivity	1.65230917
27	MP0005310_abnormal_salivary_gland	1.64707164
28	MP0006054_spinal_hemorrhage	1.64134223
29	MP0001529_abnormal_vocalization	1.63862012
30	MP0009745_abnormal_behavioral_response	1.62134229
31	MP0005646_abnormal_pituitary_gland	1.51072873
32	MP0008872_abnormal_physiological_respon	1.49351292
33	MP0003136_yellow_coat_color	1.48894181
34	MP0008057_abnormal_DNA_replication	1.47778056
35	MP0005084_abnormal_gallbladder_morpholo	1.47607316
36	MP0002272_abnormal_nervous_system	1.45641174
37	MP0003950_abnormal_plasma_membrane	1.45371624
38	MP0006276_abnormal_autonomic_nervous	1.42513817
39	MP0004043_abnormal_pH_regulation	1.38231592
40	MP0005410_abnormal_fertilization	1.34303864
41	MP0004147_increased_porphyrin_level	1.33299299
42	MP0001764_abnormal_homeostasis	1.32366554
43	MP0003943_abnormal_hepatobiliary_system	1.29737826
44	MP0005365_abnormal_bile_salt	1.28321816
45	MP0005645_abnormal_hypothalamus_physiol	1.27499718
46	MP0000427_abnormal_hair_cycle	1.23522613
47	MP0002735_abnormal_chemical_nociception	1.23357839
48	MP0004142_abnormal_muscle_tone	1.19695951
49	MP0002733_abnormal_thermal_nociception	1.19146025
50	MP0004215_abnormal_myocardial_fiber	1.18455993
51	MP0001970_abnormal_pain_threshold	1.17988940
52	MP0002067_abnormal_sensory_capabilities	1.15478798
53	MP0008775_abnormal_heart_ventricle	1.10841747
54	MP0002572_abnormal_emotion/affect_behav	1.10208599
55	MP0001502_abnormal_circadian_rhythm	1.08683772
56	MP0005171_absent_coat_pigmentation	1.04584933
57	MP0003890_abnormal_embryonic-extraembry	1.04317313
58	MP0002938_white_spotting	1.04303508
59	MP0003635_abnormal_synaptic_transmissio	1.03457194
60	MP0002064_seizures	1.00672437
61	MP0010386_abnormal_urinary_bladder	0.99547301
62	MP0001919_abnormal_reproductive_system	0.94374242
63	MP0004742_abnormal_vestibular_system	0.93457596
64	MP0009780_abnormal_chondrocyte_physiolo	0.92337774
65	MP0000383_abnormal_hair_follicle	0.90729427
66	MP0004145_abnormal_muscle_electrophysio	0.90680512
67	MP0002234_abnormal_pharynx_morphology	0.90539219
68	MP0006035_abnormal_mitochondrial_morpho	0.88111424
69	MP0003122_maternal_imprinting	0.88069230
70	MP0002751_abnormal_autonomic_nervous	0.87687837
71	MP0005391_vision/eye_phenotype	0.86399173
72	MP0002332_abnormal_exercise_endurance	0.85415039
73	MP0002928_abnormal_bile_duct	0.84714082
74	MP0002229_neurodegeneration	0.84040518
75	MP0003698_abnormal_male_reproductive	0.83723918
76	MP0004085_abnormal_heartbeat	0.82984720
77	MP0005266_abnormal_metabolism	0.82733189
78	MP0003633_abnormal_nervous_system	0.82427554
79	MP0003183_abnormal_peptide_metabolism	0.82235127
80	MP0002557_abnormal_social/conspecific_i	0.81864544
81	MP0003121_genomic_imprinting	0.81834744
82	MP0005195_abnormal_posterior_eye	0.81818422
83	MP0009697_abnormal_copulation	0.80716792
84	MP0005386_behavior/neurological_phenoty	0.80505976
85	MP0004924_abnormal_behavior	0.80505976
86	MP0003252_abnormal_bile_duct	0.79079296
87	MP0001929_abnormal_gametogenesis	0.77831542
88	MP0004133_heterotaxia	0.77565915
89	MP0005389_reproductive_system_phenotype	0.77541228
90	MP0005075_abnormal_melanosome_morpholog	0.77181426
91	MP0000631_abnormal_neuroendocrine_gland	0.77137068
92	MP0001664_abnormal_digestion	0.77107621
93	MP0000230_abnormal_systemic_arterial	0.74548783
94	MP0003045_fibrosis	0.74473027
95	MP0005647_abnormal_sex_gland	0.72820399
96	MP0005360_urolithiasis	0.72585344
97	MP0005220_abnormal_exocrine_pancreas	0.71746922
98	MP0005670_abnormal_white_adipose	0.71506749
99	MP0008058_abnormal_DNA_repair	0.71141033
100	MP0002752_abnormal_somatic_nervous	0.70150840

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.57534933
2	Pancreatic fibrosis (HP:0100732)	4.10776092
3	Pancreatic cysts (HP:0001737)	4.02303870
4	Pancreatic islet-cell hyperplasia (HP:0004510)	3.36451728
5	Intestinal atresia (HP:0011100)	3.31866906
6	Absent speech (HP:0001344)	3.27497461
7	Attenuation of retinal blood vessels (HP:0007843)	3.23456715
8	Medial flaring of the eyebrow (HP:0010747)	3.18812785
9	Focal motor seizures (HP:0011153)	3.15139580
10	Gaze-evoked nystagmus (HP:0000640)	3.13460099
11	True hermaphroditism (HP:0010459)	3.13227423
12	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.09333146
13	Abnormality of midbrain morphology (HP:0002418)	3.07150659
14	Molar tooth sign on MRI (HP:0002419)	3.07150659
15	Abnormality of the renal cortex (HP:0011035)	3.04637998
16	Chronic hepatic failure (HP:0100626)	3.01047710
17	Febrile seizures (HP:0002373)	2.97630165
18	Congenital sensorineural hearing impairment (HP:0008527)	2.88248637
19	Tubulointerstitial nephritis (HP:0001970)	2.87904763
20	Abolished electroretinogram (ERG) (HP:0000550)	2.81052815
21	Bony spicule pigmentary retinopathy (HP:0007737)	2.77765827
22	Progressive inability to walk (HP:0002505)	2.72940512
23	Ketoacidosis (HP:0001993)	2.71434891
24	Nephronophthisis (HP:0000090)	2.66403811
25	Volvulus (HP:0002580)	2.62298588
26	Congenital stationary night blindness (HP:0007642)	2.60089698
27	Cerebellar dysplasia (HP:0007033)	2.56668272
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.55484274
29	Absent/shortened dynein arms (HP:0200106)	2.55484274
30	Renal cortical cysts (HP:0000803)	2.54430036
31	Abnormality of the renal medulla (HP:0100957)	2.51879616
32	Focal seizures (HP:0007359)	2.50158330
33	Cystic liver disease (HP:0006706)	2.49548971
34	Abnormal drinking behavior (HP:0030082)	2.46504886
35	Polydipsia (HP:0001959)	2.46504886
36	Hypothermia (HP:0002045)	2.46231612
37	Central scotoma (HP:0000603)	2.39288002
38	Abnormality of endocrine pancreas physiology (HP:0012093)	2.39200083
39	Abnormality of the pancreatic islet cells (HP:0006476)	2.39200083
40	Stomach cancer (HP:0012126)	2.39057929
41	Genital tract atresia (HP:0001827)	2.38902598
42	Hemiparesis (HP:0001269)	2.38690494
43	Polyphagia (HP:0002591)	2.38301481
44	Facial diplegia (HP:0001349)	2.37960946
45	Gait imbalance (HP:0002141)	2.37942038
46	Congenital primary aphakia (HP:0007707)	2.36788141
47	Inability to walk (HP:0002540)	2.36668603
48	Abnormal ciliary motility (HP:0012262)	2.34703888
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.34131825
50	Constricted visual fields (HP:0001133)	2.33575705
51	Thyroid-stimulating hormone excess (HP:0002925)	2.30458717
52	Nephrogenic diabetes insipidus (HP:0009806)	2.30047205
53	Short foot (HP:0001773)	2.26337946
54	Type II lissencephaly (HP:0007260)	2.26155679
55	Dialeptic seizures (HP:0011146)	2.24869566
56	Tented upper lip vermilion (HP:0010804)	2.23644104
57	Abnormal biliary tract physiology (HP:0012439)	2.23097833
58	Bile duct proliferation (HP:0001408)	2.23097833
59	Postaxial foot polydactyly (HP:0001830)	2.15614354
60	Small hand (HP:0200055)	2.14915384
61	Methylmalonic aciduria (HP:0012120)	2.14170032
62	Gonadotropin excess (HP:0000837)	2.11627497
63	Ketosis (HP:0001946)	2.10611874
64	Hypoglycemic coma (HP:0001325)	2.09303493
65	Short tibia (HP:0005736)	2.07810666
66	Tubular atrophy (HP:0000092)	2.06491900
67	Methylmalonic acidemia (HP:0002912)	2.06287072
68	Congenital hepatic fibrosis (HP:0002612)	2.05465437
69	Vaginal atresia (HP:0000148)	2.05163136
70	Atonic seizures (HP:0010819)	2.03629274
71	Decreased central vision (HP:0007663)	2.02498430
72	Hyperglycinuria (HP:0003108)	2.00596714
73	Abnormal respiratory motile cilium morphology (HP:0005938)	1.99276706
74	Abnormal respiratory epithelium morphology (HP:0012253)	1.99276706
75	Postaxial hand polydactyly (HP:0001162)	1.96336530
76	Increased corneal curvature (HP:0100692)	1.92962149
77	Keratoconus (HP:0000563)	1.92962149
78	Abnormality of macular pigmentation (HP:0008002)	1.92179764
79	Disproportionate short-trunk short stature (HP:0003521)	1.90893692
80	Large for gestational age (HP:0001520)	1.90304990
81	Metaphyseal dysplasia (HP:0100255)	1.88275564
82	Barrel-shaped chest (HP:0001552)	1.84801049
83	Gastrointestinal atresia (HP:0002589)	1.82378037
84	Cone-rod dystrophy (HP:0000548)	1.82037922
85	Tubulointerstitial abnormality (HP:0001969)	1.81202775
86	Sclerocornea (HP:0000647)	1.81036980
87	Hypoglycemic seizures (HP:0002173)	1.80135421
88	Astrocytoma (HP:0009592)	1.79576571
89	Abnormality of the astrocytes (HP:0100707)	1.79576571
90	Optic nerve hypoplasia (HP:0000609)	1.79336983
91	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.79224958
92	Lissencephaly (HP:0001339)	1.78018703
93	Enlarged kidneys (HP:0000105)	1.74003711
94	Abnormal rod and cone electroretinograms (HP:0008323)	1.72858685
95	Oculomotor apraxia (HP:0000657)	1.72805389
96	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.71605021
97	Type II diabetes mellitus (HP:0005978)	1.70528302
98	Abnormal respiratory motile cilium physiology (HP:0012261)	1.70239996
99	Scotoma (HP:0000575)	1.70238957
100	Furrowed tongue (HP:0000221)	1.70206717

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.55570451
2	INSRR	4.74555413
3	ACVR1B	3.87398323
4	BMPR1B	2.88544491
5	MAP4K2	2.79764120
6	ADRBK2	2.66294979
7	NUAK1	2.55871172
8	PINK1	2.47834543
9	WNK3	2.40423636
10	LATS1	2.15855515
11	EIF2AK3	2.11626793
12	MAPK13	2.04503710
13	STK39	1.91598640
14	CASK	1.75639970
15	MAP3K4	1.72430664
16	OXSR1	1.57861739
17	TAOK3	1.54169680
18	AKT3	1.47776083
19	STK38L	1.46588109
20	PBK	1.41833178
21	NTRK3	1.41663465
22	ZAK	1.37974133
23	GRK1	1.34924107
24	PLK4	1.34436002
25	TNIK	1.30775390
26	MKNK2	1.29140949
27	PLK2	1.26371807
28	PRKCE	1.26029474
29	ERBB3	1.25101659
30	TXK	1.21923389
31	PIK3CG	1.19341335
32	WNK4	1.12819352
33	TGFBR1	1.07159264
34	PTK2B	1.00956266
35	FER	1.00091830
36	PAK3	1.00029024
37	PRKD3	0.97489567
38	TEC	0.92791060
39	MARK1	0.91156460
40	DAPK2	0.90479537
41	ADRBK1	0.89527762
42	STK3	0.86027198
43	MAP2K7	0.84062610
44	SGK2	0.76879127
45	NLK	0.75701725
46	FLT3	0.73903029
47	CSNK1G1	0.72565860
48	PDK2	0.71545887
49	PRKCG	0.69920132
50	TRIM28	0.64607130
51	BCR	0.63234914
52	CAMKK2	0.62660701
53	EPHA4	0.61707756
54	TNK2	0.60824165
55	FGFR2	0.60060454
56	OBSCN	0.56341692
57	CAMK2A	0.55979985
58	MAP2K1	0.54001990
59	MKNK1	0.51704779
60	BRSK2	0.51091318
61	DYRK1A	0.49992342
62	CSNK1G2	0.49038922
63	MUSK	0.48906037
64	PRKCQ	0.47466854
65	CSNK1A1L	0.46470324
66	DYRK3	0.44892061
67	PRKAA2	0.43885888
68	PRKG1	0.43410479
69	MAP3K2	0.41870019
70	PLK3	0.40235468
71	CSNK1G3	0.37788893
72	PRKACB	0.37439665
73	VRK1	0.36559453
74	PRKACA	0.36368729
75	PHKG2	0.35569594
76	PHKG1	0.35569594
77	CDK8	0.35096325
78	MST4	0.34010934
79	CSNK1A1	0.33446552
80	ITK	0.32534536
81	NME1	0.32178814
82	MAP2K6	0.31449905
83	SGK1	0.30947812
84	BRD4	0.30756044
85	CAMK4	0.30430606
86	MAP2K4	0.30364244
87	BMPR2	0.30280439
88	CSNK1D	0.29923943
89	ABL1	0.29635792
90	ATM	0.29616312
91	SGK494	0.29247059
92	SGK223	0.29247059
93	TIE1	0.28296827
94	IKBKB	0.28219927
95	IGF1R	0.28059495
96	MELK	0.27034626
97	PRKCB	0.26985113
98	GRK7	0.26335429
99	PRKCA	0.24327430
100	MAP3K12	0.24204064

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	2.86121329
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.67270055
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.58272816
4	Tryptophan metabolism_Homo sapiens_hsa00380	2.55455980
5	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.42103880
6	Phototransduction_Homo sapiens_hsa04744	2.41711959
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.35585379
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.24619186
9	Nicotine addiction_Homo sapiens_hsa05033	2.14883467
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.05236065
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.04120569
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.01947409
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.01558900
14	Linoleic acid metabolism_Homo sapiens_hsa00591	2.00837828
15	Taste transduction_Homo sapiens_hsa04742	1.94960938
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.91843078
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.85566368
18	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.74617153
19	Propanoate metabolism_Homo sapiens_hsa00640	1.73531175
20	ABC transporters_Homo sapiens_hsa02010	1.68421917
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.62632885
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.60317578
23	Basal transcription factors_Homo sapiens_hsa03022	1.58988413
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.58743828
25	Olfactory transduction_Homo sapiens_hsa04740	1.56495378
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.55568078
27	Fatty acid degradation_Homo sapiens_hsa00071	1.54737552
28	Protein export_Homo sapiens_hsa03060	1.51922466
29	Sphingolipid metabolism_Homo sapiens_hsa00600	1.46020320
30	Homologous recombination_Homo sapiens_hsa03440	1.45425466
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.37360436
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.37303694
33	Retinol metabolism_Homo sapiens_hsa00830	1.36384813
34	Serotonergic synapse_Homo sapiens_hsa04726	1.34088121
35	Morphine addiction_Homo sapiens_hsa05032	1.33838210
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.30019719
37	Circadian entrainment_Homo sapiens_hsa04713	1.24031782
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.21530965
39	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.20746399
40	Circadian rhythm_Homo sapiens_hsa04710	1.19642684
41	Fatty acid metabolism_Homo sapiens_hsa01212	1.18698734
42	Non-homologous end-joining_Homo sapiens_hsa03450	1.18044294
43	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.17074998
44	Glutamatergic synapse_Homo sapiens_hsa04724	1.10741350
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.09710637
46	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.04361458
47	beta-Alanine metabolism_Homo sapiens_hsa00410	1.02262568
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.00410876
49	Fatty acid elongation_Homo sapiens_hsa00062	0.97337836
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.93968784
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.93744840
52	GABAergic synapse_Homo sapiens_hsa04727	0.93338099
53	Salivary secretion_Homo sapiens_hsa04970	0.89620415
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.87465744
55	Caffeine metabolism_Homo sapiens_hsa00232	0.84819624
56	Peroxisome_Homo sapiens_hsa04146	0.83848926
57	Calcium signaling pathway_Homo sapiens_hsa04020	0.82555413
58	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.79598057
59	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.78721047
60	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.75707178
61	Insulin secretion_Homo sapiens_hsa04911	0.75503354
62	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.72575953
63	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.70923592
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69805585
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.69614246
66	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.68533454
67	Sulfur metabolism_Homo sapiens_hsa00920	0.67127125
68	Glutathione metabolism_Homo sapiens_hsa00480	0.66884935
69	Lysine degradation_Homo sapiens_hsa00310	0.63807401
70	Long-term depression_Homo sapiens_hsa04730	0.63026809
71	Steroid biosynthesis_Homo sapiens_hsa00100	0.62267663
72	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.60846715
73	Renin secretion_Homo sapiens_hsa04924	0.58201753
74	Regulation of autophagy_Homo sapiens_hsa04140	0.57796617
75	Histidine metabolism_Homo sapiens_hsa00340	0.56807993
76	RNA degradation_Homo sapiens_hsa03018	0.55997102
77	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.53870725
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53408689
79	Metabolic pathways_Homo sapiens_hsa01100	0.53215744
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.51307313
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47686153
82	RNA polymerase_Homo sapiens_hsa03020	0.46100869
83	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.42303226
84	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39821897
85	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36265658
86	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.34673337
87	PPAR signaling pathway_Homo sapiens_hsa03320	0.34511434
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.34385884
89	Mineral absorption_Homo sapiens_hsa04978	0.33948211
90	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.33364988
91	Purine metabolism_Homo sapiens_hsa00230	0.32048682
92	Cocaine addiction_Homo sapiens_hsa05030	0.31956090
93	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.30890041
94	Cholinergic synapse_Homo sapiens_hsa04725	0.30767592
95	Amphetamine addiction_Homo sapiens_hsa05031	0.29954540
96	Asthma_Homo sapiens_hsa05310	0.28115540
97	Type II diabetes mellitus_Homo sapiens_hsa04930	0.26837885
98	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.25055221
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.24253186
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.22729717

CDK4PS

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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