CDK5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.39999112
2central nervous system myelination (GO:0022010)6.39999112
3protein maturation by protein folding (GO:0022417)4.87094031
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.68282809
5neuronal action potential propagation (GO:0019227)4.59270075
6neuron cell-cell adhesion (GO:0007158)4.58194507
7presynaptic membrane organization (GO:0097090)4.45990446
8synaptic vesicle maturation (GO:0016188)4.39228265
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.35397363
10* synaptic vesicle exocytosis (GO:0016079)4.29522229
11presynaptic membrane assembly (GO:0097105)4.21162823
12glutamate secretion (GO:0014047)4.19117539
13regulation of mitochondrial translation (GO:0070129)4.01967355
14energy coupled proton transport, down electrochemical gradient (GO:0015985)3.99033245
15ATP synthesis coupled proton transport (GO:0015986)3.99033245
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.97965506
17regulation of synaptic vesicle exocytosis (GO:2000300)3.97250214
18long-chain fatty acid biosynthetic process (GO:0042759)3.92932992
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.91142774
20cullin deneddylation (GO:0010388)3.89451198
21fatty acid elongation (GO:0030497)3.85199119
22myelination (GO:0042552)3.77498790
23vocalization behavior (GO:0071625)3.76410043
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.75406818
25respiratory electron transport chain (GO:0022904)3.75038185
26ensheathment of neurons (GO:0007272)3.73657139
27axon ensheathment (GO:0008366)3.73657139
28* positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.72398920
29protein deneddylation (GO:0000338)3.67373804
30protein targeting to mitochondrion (GO:0006626)3.66900232
31electron transport chain (GO:0022900)3.64475963
32* protein localization to synapse (GO:0035418)3.60199623
33proteasome assembly (GO:0043248)3.59006100
34transmission of nerve impulse (GO:0019226)3.57003194
35establishment of protein localization to mitochondrion (GO:0072655)3.51029554
36adult walking behavior (GO:0007628)3.48493126
37protein complex biogenesis (GO:0070271)3.45142077
38regulation of synaptic vesicle transport (GO:1902803)3.39842511
39oxidative phosphorylation (GO:0006119)3.37732320
40protein localization to mitochondrion (GO:0070585)3.37561495
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.37119505
42negative regulation of neurotransmitter transport (GO:0051589)3.36965072
43positive regulation of membrane potential (GO:0045838)3.36527543
44cerebellar Purkinje cell layer development (GO:0021680)3.35054061
45mitochondrial respiratory chain complex assembly (GO:0033108)3.35020577
46regulation of neuronal synaptic plasticity (GO:0048168)3.34846913
47neuron recognition (GO:0008038)3.33208060
48establishment of mitochondrion localization (GO:0051654)3.32842326
49ionotropic glutamate receptor signaling pathway (GO:0035235)3.26583607
50regulation of glutamate receptor signaling pathway (GO:1900449)3.24341650
51neuronal ion channel clustering (GO:0045161)3.23637245
52locomotory exploration behavior (GO:0035641)3.16519362
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15779701
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.15779701
55NADH dehydrogenase complex assembly (GO:0010257)3.15779701
56* neuron-neuron synaptic transmission (GO:0007270)3.15140826
57neurotransmitter secretion (GO:0007269)3.13456069
58substantia nigra development (GO:0021762)3.11673226
59peptidyl-arginine omega-N-methylation (GO:0035247)3.10513742
60* synaptic transmission, glutamatergic (GO:0035249)3.09879074
61gamma-aminobutyric acid signaling pathway (GO:0007214)3.09858070
62regulation of long-term neuronal synaptic plasticity (GO:0048169)3.07972440
63establishment of protein localization to mitochondrial membrane (GO:0090151)3.07802795
64gamma-aminobutyric acid transport (GO:0015812)3.07028226
65synaptic vesicle docking involved in exocytosis (GO:0016081)3.06463717
66guanosine-containing compound biosynthetic process (GO:1901070)3.05587093
67negative regulation of neurotransmitter secretion (GO:0046929)3.05253310
68mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.03372395
69transcription elongation from RNA polymerase III promoter (GO:0006385)3.02507358
70termination of RNA polymerase III transcription (GO:0006386)3.02507358
71glutamate receptor signaling pathway (GO:0007215)3.02251343
72detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.01277317
73detection of temperature stimulus involved in sensory perception (GO:0050961)3.01277317
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00312435
75dendritic spine morphogenesis (GO:0060997)2.99894782
76de novo posttranslational protein folding (GO:0051084)2.99228229
77regulation of voltage-gated calcium channel activity (GO:1901385)2.97841217
78cell migration in hindbrain (GO:0021535)2.97446262
79de novo protein folding (GO:0006458)2.97209829
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96612164
81transferrin transport (GO:0033572)2.94469239
82deoxyribose phosphate biosynthetic process (GO:0046385)2.94134700
832-deoxyribonucleotide biosynthetic process (GO:0009265)2.94134700
84nuclear envelope reassembly (GO:0031468)2.93560446
85mitotic nuclear envelope reassembly (GO:0007084)2.93560446
86chaperone-mediated protein transport (GO:0072321)2.93421187
87positive regulation of mitochondrial fission (GO:0090141)2.91596780
88protein insertion into membrane (GO:0051205)2.91261241
89axonal fasciculation (GO:0007413)2.90251464
90membrane hyperpolarization (GO:0060081)2.89261456
91respiratory chain complex IV assembly (GO:0008535)2.87785667
92negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.86330299
93pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.85909505
94regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.85653767
95regulation of glutamate secretion (GO:0014048)2.85559897
96neurotransmitter-gated ion channel clustering (GO:0072578)2.85331367
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85024590
98positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84387814
99neurotransmitter transport (GO:0006836)2.83464801
100mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.83347941
101calcium-mediated signaling using intracellular calcium source (GO:0035584)2.83251249
102regulation of neurotransmitter secretion (GO:0046928)2.83179784
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82923285
104glycerophospholipid catabolic process (GO:0046475)2.82629528
105negative regulation of ligase activity (GO:0051352)2.81488797
106negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81488797
107apical protein localization (GO:0045176)2.81196139
108regulation of dopamine metabolic process (GO:0042053)2.80734481
109regulation of catecholamine metabolic process (GO:0042069)2.80734481
110positive regulation of action potential (GO:0045760)2.80149943
111regulation of collateral sprouting (GO:0048670)2.79820446
112regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79812457
113regulation of vesicle fusion (GO:0031338)2.79573705
114regulation of cellular amino acid metabolic process (GO:0006521)2.78852073
115mating behavior (GO:0007617)2.78599864
116postsynaptic membrane organization (GO:0001941)2.78438624
117GTP biosynthetic process (GO:0006183)2.78184235
118neuromuscular process controlling posture (GO:0050884)2.77870642
119positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77384564
120* regulation of excitatory postsynaptic membrane potential (GO:0060079)2.76621300
121nucleobase-containing small molecule interconversion (GO:0015949)2.76620841
122* negative regulation of axonogenesis (GO:0050771)2.74432258
123neurofilament cytoskeleton organization (GO:0060052)2.74376068
124positive regulation of synaptic transmission, GABAergic (GO:0032230)2.73976567
125regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.73635804
126regulation of synapse structural plasticity (GO:0051823)2.72343428
127iron-sulfur cluster assembly (GO:0016226)2.71992275
128metallo-sulfur cluster assembly (GO:0031163)2.71992275
129histone arginine methylation (GO:0034969)2.71653253
130* regulation of synaptic plasticity (GO:0048167)2.71443978
131negative regulation of microtubule polymerization (GO:0031115)2.71143111
132hydrogen ion transmembrane transport (GO:1902600)2.71047321
133glycine transport (GO:0015816)2.70669564
134cerebellar granule cell differentiation (GO:0021707)2.70508083
135peptidyl-tyrosine autophosphorylation (GO:0038083)2.70424000
136long-term memory (GO:0007616)2.70378651
137exploration behavior (GO:0035640)2.70326536
138purine nucleoside triphosphate biosynthetic process (GO:0009145)2.70228801
139establishment of integrated proviral latency (GO:0075713)2.69951893
140purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.69826579
141regulation of amyloid precursor protein catabolic process (GO:1902991)2.69075956
142neurotransmitter uptake (GO:0001504)2.69038122
143positive regulation of dendritic spine morphogenesis (GO:0061003)2.68437108
144long-term synaptic potentiation (GO:0060291)2.68292263
145positive regulation of synapse assembly (GO:0051965)2.68281699
146establishment of viral latency (GO:0019043)2.67983046
147mitochondrial transport (GO:0006839)2.67456077
148* oligodendrocyte differentiation (GO:0048709)2.67270568
149ATP biosynthetic process (GO:0006754)2.67187319
150mitochondrion transport along microtubule (GO:0047497)2.66661259
151establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.66661259
152* regulation of postsynaptic membrane potential (GO:0060078)2.66084741
153regulation of neurotransmitter transport (GO:0051588)2.65632806
154regulation of synaptic transmission, GABAergic (GO:0032228)2.65462392
155energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.64831626
156ATP hydrolysis coupled proton transport (GO:0015991)2.64831626
157GDP-mannose metabolic process (GO:0019673)2.64692597
158ferric iron transport (GO:0015682)2.64223860
159trivalent inorganic cation transport (GO:0072512)2.64223860
160L-amino acid import (GO:0043092)2.64163354
161peptidyl-arginine methylation (GO:0018216)2.63513642
162peptidyl-arginine N-methylation (GO:0035246)2.63513642
163gluconeogenesis (GO:0006094)2.63040719
164adult locomotory behavior (GO:0008344)2.62568430
165UTP biosynthetic process (GO:0006228)2.62502403
166positive regulation of synapse maturation (GO:0090129)2.60697474
167organelle transport along microtubule (GO:0072384)2.60655071
168Golgi transport vesicle coating (GO:0048200)2.60096553
169COPI coating of Golgi vesicle (GO:0048205)2.60096553
170regulation of neurotransmitter levels (GO:0001505)2.58874667
171cytochrome complex assembly (GO:0017004)2.58791376
172regulation of synaptic transmission, glutamatergic (GO:0051966)2.57530410
173ribonucleoside triphosphate biosynthetic process (GO:0009201)2.55728849
174positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.55495154
175dendritic spine organization (GO:0097061)2.54941869
176cellular potassium ion homeostasis (GO:0030007)2.54172354
177DNA damage response, detection of DNA damage (GO:0042769)2.50809048
178tricarboxylic acid cycle (GO:0006099)2.50571000
179L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.49007586
180pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.48777107
181positive regulation of TOR signaling (GO:0032008)2.47035114
182hexose biosynthetic process (GO:0019319)2.45266954

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.85924701
2* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.12106677
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.78401413
4GBX2_23144817_ChIP-Seq_PC3_Human3.77816239
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70012622
6* HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.57617350
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.44788093
8* THAP11_20581084_ChIP-Seq_MESCs_Mouse3.32681209
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17482770
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.11774746
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08074231
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.06902357
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95774184
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.90151836
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.88151987
16* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.77367997
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73057618
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70475673
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70475673
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63043205
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61194404
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.58476526
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57352447
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55168690
25* EST1_17652178_ChIP-ChIP_JURKAT_Human2.53949768
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52108012
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49483054
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49358303
29* REST_21632747_ChIP-Seq_MESCs_Mouse2.37762067
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.36680085
31SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36557675
32XRN2_22483619_ChIP-Seq_HELA_Human2.34863904
33EZH2_27294783_Chip-Seq_ESCs_Mouse2.33809069
34YY1_21170310_ChIP-Seq_MESCs_Mouse2.31618100
35TAF15_26573619_Chip-Seq_HEK293_Human2.25609612
36* GABP_19822575_ChIP-Seq_HepG2_Human2.24814557
37RARB_27405468_Chip-Seq_BRAIN_Mouse2.21634175
38DCP1A_22483619_ChIP-Seq_HELA_Human2.20940367
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19439793
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.16115076
41* CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.14831855
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11498599
43RNF2_27304074_Chip-Seq_ESCs_Mouse2.09433745
44MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08295047
45E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06709860
46REST_18959480_ChIP-ChIP_MESCs_Mouse2.05408091
47SIN3A_21632747_ChIP-Seq_MESCs_Mouse2.01972416
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.96057736
49DROSHA_22980978_ChIP-Seq_HELA_Human1.94975291
50* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91197656
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90924234
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.87306006
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83937978
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82355056
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80550286
56ZNF263_19887448_ChIP-Seq_K562_Human1.78636468
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78428026
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73044324
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72437078
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72199178
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71108965
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.70039760
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69146655
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68926683
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66068584
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65750841
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.65347776
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64981081
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64944449
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.64126672
71AR_21572438_ChIP-Seq_LNCaP_Human1.62522626
72* TTF2_22483619_ChIP-Seq_HELA_Human1.58370686
73* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54824717
74CTCF_18555785_ChIP-Seq_MESCs_Mouse1.51461261
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49713882
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49301623
77* TET1_21451524_ChIP-Seq_MESCs_Mouse1.47033970
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.47029436
79FOXP3_21729870_ChIP-Seq_TREG_Human1.45136775
80* VDR_23849224_ChIP-Seq_CD4+_Human1.44376396
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44281018
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42599187
83* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.40951936
84SMAD4_21799915_ChIP-Seq_A2780_Human1.40869095
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40343494
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38816209
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.37971162
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37242153
89* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.37149944
90P300_19829295_ChIP-Seq_ESCs_Human1.37114154
91RNF2_27304074_Chip-Seq_NSC_Mouse1.36407805
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.36071601
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33673829
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28256924
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28054050
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27870057
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27411309
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26195021
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24777867
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24702659
101VDR_22108803_ChIP-Seq_LS180_Human1.24264122
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.24180774
103FOXP1_21924763_ChIP-Seq_HESCs_Human1.23681137
104ER_23166858_ChIP-Seq_MCF-7_Human1.22418643
105* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22170210
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21935395
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21164030
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21152334
109E2F7_22180533_ChIP-Seq_HELA_Human1.20594456
110RING1B_27294783_Chip-Seq_ESCs_Mouse1.19547811
111TBX5_21415370_ChIP-Seq_HL-1_Mouse1.19546185
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19191691
113SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17179014
114POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15909418
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15133416
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14716781
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14688478
118* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.14383263
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14377406
120HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13238308
121* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13114135
122ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12556185
123CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12430712
124KDM5A_27292631_Chip-Seq_BREAST_Human1.11980432
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11816283
126FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11258128
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10890838
128DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10846331
129SOX2_21211035_ChIP-Seq_LN229_Gbm1.10680143
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10571012
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08224106
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08129938
133ZNF274_21170338_ChIP-Seq_K562_Hela1.08058797
134* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08008960
135ELF1_20517297_ChIP-Seq_JURKAT_Human1.07962033
136* STAT3_23295773_ChIP-Seq_U87_Human1.07220088
137* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06695448
138ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04915560
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04674216
140* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03879878
141PRDM14_20953172_ChIP-Seq_ESCs_Human1.03206762
142PIAS1_25552417_ChIP-Seq_VCAP_Human1.02768436
143SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02390852
144MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02331474
145RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01336912
146AR_25329375_ChIP-Seq_VCAP_Human1.01125806
147NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00600493
148EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99460450
149UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99182968
150RING1B_27294783_Chip-Seq_NPCs_Mouse0.97673243
151* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97502288
152JUN_21703547_ChIP-Seq_K562_Human0.97051995
153P68_20966046_ChIP-Seq_HELA_Human0.97039466
154FUS_26573619_Chip-Seq_HEK293_Human0.96875199
155WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96285532
156E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95976739
157OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95711746
158IGF1R_20145208_ChIP-Seq_DFB_Human0.95447923
159TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95322465
160E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95183245
161TCF4_23295773_ChIP-Seq_U87_Human0.94999888
162TFEB_21752829_ChIP-Seq_HELA_Human0.94410653
163GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94146703
164LXR_22292898_ChIP-Seq_THP-1_Human0.93461449
165AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93084084
166CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92679994
167TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.92381191
168OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92028136
169RUNX2_22187159_ChIP-Seq_PCA_Human0.91807833
170MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91522303
171* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91521602
172ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91402290
173MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91382756
174CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89684212
175AHR_22903824_ChIP-Seq_MCF-7_Human0.87137002
176EOMES_21245162_ChIP-Seq_HESCs_Human0.87032077
177TET1_21490601_ChIP-Seq_MESCs_Mouse0.86987632
178ARNT_22903824_ChIP-Seq_MCF-7_Human0.85766528
179CTCF_27219007_Chip-Seq_Bcells_Human0.85332453
180STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82468789
181PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82445369
182NANOG_18555785_Chip-Seq_ESCs_Mouse0.80843080
183AR_19668381_ChIP-Seq_PC3_Human0.80813914
184SOX9_26525672_Chip-Seq_HEART_Mouse0.80381598
185NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79819296
186KDM2B_26808549_Chip-Seq_REH_Human0.79223014
187LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79145941
188NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78578897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.15771694
2* MP0004859_abnormal_synaptic_plasticity4.62672736
3* MP0004270_analgesia3.51067019
4* MP0003635_abnormal_synaptic_transmissio3.37623042
5MP0002064_seizures3.10334549
6MP0009745_abnormal_behavioral_response3.01159762
7MP0002272_abnormal_nervous_system2.88226526
8MP0001968_abnormal_touch/_nociception2.76873912
9MP0009046_muscle_twitch2.74271241
10MP0000920_abnormal_myelination2.69129353
11MP0002063_abnormal_learning/memory/cond2.66955622
12* MP0002734_abnormal_mechanical_nocicepti2.66044046
13MP0001486_abnormal_startle_reflex2.59495343
14MP0006035_abnormal_mitochondrial_morpho2.52704848
15MP0005423_abnormal_somatic_nervous2.46807779
16MP0002735_abnormal_chemical_nociception2.45038139
17MP0002572_abnormal_emotion/affect_behav2.43810022
18MP0003329_amyloid_beta_deposits2.43112739
19MP0001529_abnormal_vocalization2.40792961
20MP0002736_abnormal_nociception_after2.30080185
21MP0001905_abnormal_dopamine_level2.24248764
22MP0000778_abnormal_nervous_system2.24006456
23MP0001970_abnormal_pain_threshold2.16360823
24MP0002733_abnormal_thermal_nociception2.11178058
25MP0001440_abnormal_grooming_behavior2.10215193
26MP0004142_abnormal_muscle_tone2.09084772
27MP0006276_abnormal_autonomic_nervous2.02633910
28MP0006036_abnormal_mitochondrial_physio1.99345077
29MP0002067_abnormal_sensory_capabilities1.96071955
30MP0003123_paternal_imprinting1.82098516
31MP0002822_catalepsy1.75712893
32MP0002184_abnormal_innervation1.72339760
33MP0005386_behavior/neurological_phenoty1.72222123
34MP0004924_abnormal_behavior1.72222123
35* MP0000955_abnormal_spinal_cord1.70683090
36MP0004742_abnormal_vestibular_system1.67000995
37MP0008569_lethality_at_weaning1.66250799
38MP0004885_abnormal_endolymph1.63518063
39MP0003634_abnormal_glial_cell1.61136787
40MP0001501_abnormal_sleep_pattern1.60565923
41* MP0002882_abnormal_neuron_morphology1.59701992
42MP0001984_abnormal_olfaction1.57542451
43MP0008058_abnormal_DNA_repair1.57501247
44MP0004811_abnormal_neuron_physiology1.54387515
45MP0002229_neurodegeneration1.53131177
46MP0002557_abnormal_social/conspecific_i1.51636268
47MP0005171_absent_coat_pigmentation1.50167695
48* MP0002066_abnormal_motor_capabilities/c1.48608993
49MP0003690_abnormal_glial_cell1.46144905
50MP0000358_abnormal_cell_content/1.44417797
51MP0005646_abnormal_pituitary_gland1.43055294
52MP0003693_abnormal_embryo_hatching1.39976735
53MP0003806_abnormal_nucleotide_metabolis1.38822846
54MP0001485_abnormal_pinna_reflex1.37789987
55MP0003111_abnormal_nucleus_morphology1.34404193
56MP0002102_abnormal_ear_morphology1.32162676
57MP0003186_abnormal_redox_activity1.30425629
58MP0001986_abnormal_taste_sensitivity1.30295377
59MP0008932_abnormal_embryonic_tissue1.28097495
60MP0005645_abnormal_hypothalamus_physiol1.27147722
61MP0004858_abnormal_nervous_system1.25297166
62MP0003122_maternal_imprinting1.22672914
63MP0003631_nervous_system_phenotype1.19101438
64MP0003879_abnormal_hair_cell1.18849766
65MP0003632_abnormal_nervous_system1.18717469
66MP0003786_premature_aging1.18559731
67MP0003633_abnormal_nervous_system1.18390416
68MP0003121_genomic_imprinting1.16089299
69MP0001188_hyperpigmentation1.15559059
70MP0001963_abnormal_hearing_physiology1.14622066
71MP0005551_abnormal_eye_electrophysiolog1.14292155
72MP0003787_abnormal_imprinting1.13466745
73MP0000604_amyloidosis1.11263582
74MP0001502_abnormal_circadian_rhythm1.10446576
75* MP0002752_abnormal_somatic_nervous1.09669638
76MP0003718_maternal_effect1.09386159
77MP0003077_abnormal_cell_cycle1.08535653
78MP0005058_abnormal_lysosome_morphology1.07485627
79MP0004043_abnormal_pH_regulation1.07483663
80MP0009780_abnormal_chondrocyte_physiolo1.05165227
81MP0002152_abnormal_brain_morphology1.03856921
82MP0004957_abnormal_blastocyst_morpholog1.03026463
83MP0010386_abnormal_urinary_bladder1.02374569
84MP0008789_abnormal_olfactory_epithelium1.02363026
85MP0010094_abnormal_chromosome_stability0.98523427
86MP0005409_darkened_coat_color0.96614002
87MP0005499_abnormal_olfactory_system0.90722353
88MP0005394_taste/olfaction_phenotype0.90722353
89MP0000751_myopathy0.87662645
90MP0000372_irregular_coat_pigmentation0.86987266
91MP0000631_abnormal_neuroendocrine_gland0.86879276
92MP0002751_abnormal_autonomic_nervous0.85989550
93MP0005410_abnormal_fertilization0.84913310
94MP0008260_abnormal_autophagy0.84145324
95* MP0002069_abnormal_eating/drinking_beha0.82336465
96MP0002234_abnormal_pharynx_morphology0.81680860
97MP0000639_abnormal_adrenal_gland0.81655256
98MP0004145_abnormal_muscle_electrophysio0.80058357
99MP0001727_abnormal_embryo_implantation0.79913695
100MP0005451_abnormal_body_composition0.79540025
101MP0008007_abnormal_cellular_replicative0.77397367
102MP0001177_atelectasis0.76673405
103MP0002638_abnormal_pupillary_reflex0.76654349
104MP0002909_abnormal_adrenal_gland0.76403786
105MP0000015_abnormal_ear_pigmentation0.76368986
106MP0000026_abnormal_inner_ear0.75397448
107MP0000749_muscle_degeneration0.73961510
108MP0000049_abnormal_middle_ear0.72732680
109MP0001664_abnormal_digestion0.71952039
110MP0002837_dystrophic_cardiac_calcinosis0.69296600
111MP0008872_abnormal_physiological_respon0.68195722
112MP0008874_decreased_physiological_sensi0.68039261
113MP0002090_abnormal_vision0.67692428
114MP0000013_abnormal_adipose_tissue0.67509358
115MP0001299_abnormal_eye_distance/0.67119923
116MP0004085_abnormal_heartbeat0.66217155
117MP0005623_abnormal_meninges_morphology0.66022090
118MP0005535_abnormal_body_temperature0.64247432
119MP0004147_increased_porphyrin_level0.64112014
120MP0002160_abnormal_reproductive_system0.63443039
121MP0001348_abnormal_lacrimal_gland0.61936683
122MP0003956_abnormal_body_size0.60858331
123MP0006072_abnormal_retinal_apoptosis0.60513816
124MP0001764_abnormal_homeostasis0.60486078
125MP0005187_abnormal_penis_morphology0.60315670
126MP0003137_abnormal_impulse_conducting0.59042340
127MP0005253_abnormal_eye_physiology0.58806783
128MP0003183_abnormal_peptide_metabolism0.58561698
129* MP0001943_abnormal_respiration0.55417343
130MP0003195_calcinosis0.54604109
131MP0002876_abnormal_thyroid_physiology0.54118999
132MP0000747_muscle_weakness0.53923633
133MP0003136_yellow_coat_color0.53607210

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.30049352
2Focal motor seizures (HP:0011153)5.50311748
3Neurofibrillary tangles (HP:0002185)4.10728704
4Supranuclear gaze palsy (HP:0000605)3.94611141
5Atonic seizures (HP:0010819)3.91168613
6Focal seizures (HP:0007359)3.90919590
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.88980162
8Degeneration of the lateral corticospinal tracts (HP:0002314)3.88980162
9Epileptic encephalopathy (HP:0200134)3.65678844
10Hepatic necrosis (HP:0002605)3.64589339
11Sensory axonal neuropathy (HP:0003390)3.56621717
12Visual hallucinations (HP:0002367)3.44840312
13Abnormal gallbladder physiology (HP:0012438)3.39608601
14Cholecystitis (HP:0001082)3.39608601
15Abnormality of the corticospinal tract (HP:0002492)3.39605038
16Ankle clonus (HP:0011448)3.38383667
17Cerebral hypomyelination (HP:0006808)3.33422229
18Pheochromocytoma (HP:0002666)3.23551057
19Cerebral inclusion bodies (HP:0100314)3.21083476
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10731152
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10731152
22Spastic gait (HP:0002064)3.09113263
23Absence seizures (HP:0002121)3.07355491
24Peripheral hypomyelination (HP:0007182)3.04384139
25Gait imbalance (HP:0002141)3.01899945
26Dysmetria (HP:0001310)3.01190317
27Neuroendocrine neoplasm (HP:0100634)3.01136878
28Dialeptic seizures (HP:0011146)3.00925674
29Progressive cerebellar ataxia (HP:0002073)2.99925451
30Cerebral edema (HP:0002181)2.89135725
31Emotional lability (HP:0000712)2.87636588
32Scanning speech (HP:0002168)2.85618823
33Limb dystonia (HP:0002451)2.85601441
34Lactic acidosis (HP:0003128)2.76813367
35Acute necrotizing encephalopathy (HP:0006965)2.75971773
36Vaginal atresia (HP:0000148)2.71089262
37Action tremor (HP:0002345)2.68446707
38Leukodystrophy (HP:0002415)2.68116374
39Abnormality of the anterior horn cell (HP:0006802)2.67700812
40Degeneration of anterior horn cells (HP:0002398)2.67700812
41Intention tremor (HP:0002080)2.66918488
42Akinesia (HP:0002304)2.66817380
43Febrile seizures (HP:0002373)2.66628636
44Increased serum lactate (HP:0002151)2.65676206
45Congenital primary aphakia (HP:0007707)2.64723764
46Generalized tonic-clonic seizures (HP:0002069)2.63960708
47Genital tract atresia (HP:0001827)2.62223778
48Mitochondrial inheritance (HP:0001427)2.61460295
49Increased intramyocellular lipid droplets (HP:0012240)2.61137201
50Hyperventilation (HP:0002883)2.59937311
51Insidious onset (HP:0003587)2.57077201
52Termporal pattern (HP:0011008)2.57077201
53Megalencephaly (HP:0001355)2.56296359
54Respiratory failure (HP:0002878)2.54735977
55Medial flaring of the eyebrow (HP:0010747)2.53442403
56Renal Fanconi syndrome (HP:0001994)2.51094221
57Abnormality of glycolysis (HP:0004366)2.50764024
58Increased serum pyruvate (HP:0003542)2.50764024
59Anxiety (HP:0000739)2.46756861
60Abnormal eating behavior (HP:0100738)2.46578915
61Exercise intolerance (HP:0003546)2.46215144
62Broad-based gait (HP:0002136)2.45741859
63Progressive inability to walk (HP:0002505)2.44336140
64Microvesicular hepatic steatosis (HP:0001414)2.44212341
65Retinal dysplasia (HP:0007973)2.44211848
66Abnormal mitochondria in muscle tissue (HP:0008316)2.43964468
67Nephrogenic diabetes insipidus (HP:0009806)2.43899931
68Onion bulb formation (HP:0003383)2.41014846
69Progressive macrocephaly (HP:0004481)2.40465873
70Hypokinesia (HP:0002375)2.40087084
71CNS demyelination (HP:0007305)2.33181290
72Lower limb muscle weakness (HP:0007340)2.29257472
73Poor suck (HP:0002033)2.28497245
74Increased hepatocellular lipid droplets (HP:0006565)2.24183514
75Abnormal hair whorl (HP:0010721)2.23697248
76Gaze-evoked nystagmus (HP:0000640)2.21659944
77CNS hypomyelination (HP:0003429)2.19772888
78Specific learning disability (HP:0001328)2.18944966
79Truncal ataxia (HP:0002078)2.18697819
80Progressive microcephaly (HP:0000253)2.18506486
81Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.17715768
82Hepatocellular necrosis (HP:0001404)2.16030825
83X-linked dominant inheritance (HP:0001423)2.15162832
84Abnormality of aromatic amino acid family metabolism (HP:0004338)2.14518362
85Increased muscle lipid content (HP:0009058)2.14398973
86Acute encephalopathy (HP:0006846)2.11100328
87Delusions (HP:0000746)2.10411169
88Depression (HP:0000716)2.08662026
89Polyphagia (HP:0002591)2.08463213
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07351544
91Parakeratosis (HP:0001036)2.06597778
92Poor speech (HP:0002465)2.06581941
93Generalized myoclonic seizures (HP:0002123)2.06254360
94Increased CSF lactate (HP:0002490)2.05952774
95Muscular hypotonia of the trunk (HP:0008936)2.05562860
96Mutism (HP:0002300)2.05250466
97Insomnia (HP:0100785)2.04495198
98Torticollis (HP:0000473)2.03623371
99Poor eye contact (HP:0000817)2.02890512
100Epileptiform EEG discharges (HP:0011182)2.01713473
101Abnormality of the motor neurons (HP:0002450)2.00644397
102Abnormal neuron morphology (HP:0012757)2.00644397
103Urinary urgency (HP:0000012)1.99635200
104Abnormal auditory evoked potentials (HP:0006958)1.98106474
105Cerebellar atrophy (HP:0001272)1.95936427
106EEG with generalized epileptiform discharges (HP:0011198)1.95656372
107Upper limb muscle weakness (HP:0003484)1.95439657
108Amblyopia (HP:0000646)1.95120387
109Rough bone trabeculation (HP:0100670)1.93893148
110Thickened helices (HP:0000391)1.92762590
111Diminished movement (HP:0002374)1.92181717
112Urinary bladder sphincter dysfunction (HP:0002839)1.91326128
113Atrophy/Degeneration involving motor neurons (HP:0007373)1.91297219
114Slow saccadic eye movements (HP:0000514)1.90916546
115Hypsarrhythmia (HP:0002521)1.90877591
116Testicular atrophy (HP:0000029)1.90052132
117Gliosis (HP:0002171)1.89012405
118Focal dystonia (HP:0004373)1.88641527
119Methylmalonic aciduria (HP:0012120)1.87797746
120Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86453021
121Alacrima (HP:0000522)1.86425739
122Foot dorsiflexor weakness (HP:0009027)1.86276956
1233-Methylglutaconic aciduria (HP:0003535)1.85025444
124Failure to thrive in infancy (HP:0001531)1.84901930
125Dysdiadochokinesis (HP:0002075)1.84513107
126Neuronal loss in central nervous system (HP:0002529)1.82898838
127Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.82863718
128Inability to walk (HP:0002540)1.82676301
129Cholelithiasis (HP:0001081)1.82466670
130Craniofacial dystonia (HP:0012179)1.82269948
131Hand muscle atrophy (HP:0009130)1.81909014
132Unsteady gait (HP:0002317)1.81884520
133Horizontal nystagmus (HP:0000666)1.80255763
134Clonus (HP:0002169)1.80034788
135Impaired vibration sensation in the lower limbs (HP:0002166)1.79489673
136Psychosis (HP:0000709)1.79449996
137Sensorimotor neuropathy (HP:0007141)1.79222888
138Split foot (HP:0001839)1.78939414
139Limb ataxia (HP:0002070)1.78821763
140Opisthotonus (HP:0002179)1.78403333
141Lipid accumulation in hepatocytes (HP:0006561)1.78360980
142Postnatal microcephaly (HP:0005484)1.78190660
143Poor coordination (HP:0002370)1.77757699
144Rigidity (HP:0002063)1.76443011
145Cortical dysplasia (HP:0002539)1.76424655
146Agitation (HP:0000713)1.74802863
147Optic disc pallor (HP:0000543)1.72402393
148Abnormality of the foot musculature (HP:0001436)1.68935637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.43936442
2NME23.35429102
3TESK13.16619667
4EPHA43.05508403
5CDK193.01684502
6OXSR12.97828581
7CASK2.82671114
8NTRK32.68162223
9VRK22.59982063
10BUB12.59117273
11STK162.57099821
12PRPF4B2.42451177
13MARK12.41608923
14BCR2.40981055
15MAP3K92.19875281
16ARAF2.14692527
17LIMK12.08458316
18PAK62.08257883
19TRIM282.01270494
20MINK11.99808044
21MAP2K71.97689453
22PDK21.97169721
23BCKDK1.92940725
24MAP3K41.90493511
25NTRK11.87840660
26UHMK11.87088255
27MAP3K121.80201674
28NEK11.75470083
29WNK41.70199330
30DAPK21.69618869
31TNIK1.66929890
32PIM21.64484499
33NTRK21.57922062
34PKN11.57380480
35PNCK1.53833528
36CAMK2B1.49077568
37BRSK11.47733410
38MAP3K111.47210627
39EIF2AK11.43804305
40KSR21.42542452
41* CDK51.36191739
42AURKA1.32103049
43MAPKAPK51.31897345
44SGK2231.29752704
45SGK4941.29752704
46WNK11.29732187
47IRAK31.24925360
48GRK51.23180649
49PLK21.22662746
50CCNB11.21936630
51CDK141.21498633
52MAPK131.20165047
53FGFR21.19790640
54PHKG11.17144029
55PHKG21.17144029
56CDK181.15481050
57CDK151.11772071
58SRPK11.08568867
59CAMK2D1.08376895
60CAMK2A1.08359130
61ROCK21.07384277
62NEK61.06416227
63MAP2K41.02405531
64PAK31.02285183
65ABL21.01952555
66TYRO31.01626443
67RIPK41.01180704
68CDK11A1.01006757
69CAMK2G1.00530775
70SCYL20.97792489
71BMPR20.97419159
72TSSK60.89352687
73PRKD30.88797329
74KSR10.88717409
75PRKCG0.87916417
76PINK10.87670240
77NME10.84786435
78WNK30.82712596
79* CSNK1G10.82513217
80CAMKK10.81166659
81VRK10.80105544
82IRAK20.78195840
83FGR0.76627064
84ILK0.76546020
85DAPK30.75944379
86SIK20.75776079
87TTK0.75608330
88PAK40.75482923
89PRKCE0.75222470
90FES0.74032375
91* CSNK1G30.73264958
92* CSNK1G20.72622514
93DYRK20.72175494
94TAOK20.70964145
95MET0.70820359
96PTK2B0.69795868
97BRAF0.69711841
98PRKCI0.68810875
99PRKCH0.68173780
100PLK30.66735284
101MAP3K20.66313412
102EPHB10.66072521
103TESK20.66018509
104MARK20.65224868
105BMPR1B0.63838355
106PAK10.63831719
107DAPK10.61913912
108MAP3K130.61619983
109PLK10.61486713
110SIK30.60934122
111PDPK10.57488418
112CAMKK20.54640574
113CDC70.53745699
114MUSK0.52957628
115RET0.51206079
116DYRK1A0.51108388
117* CSNK1A1L0.48498812
118GRK70.47680670
119LMTK20.47612790
120ICK0.45517612
121TLK10.44029229
122STK110.43793495
123MAPKAPK30.43496474
124PRKCQ0.42075011
125ADRBK20.42005022
126PRKCZ0.41380410
127CHEK20.41217137
128MAP4K20.38590429
129CAMK10.37503508
130* FYN0.37445714
131RAF10.37333825
132SGK10.37259839
133PBK0.37067420
134PRKACA0.36499139
135CDK70.36002499
136STK380.35947123
137ZAK0.35834284
138ATR0.34954902
139PRKD10.34644624
140PDK10.34465446
141FER0.33427998
142CSNK2A20.33297682
143CSNK2A10.30416233
144AKT20.29409238
145AURKB0.28750611

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.48099843
2Proteasome_Homo sapiens_hsa030503.01629124
3Nicotine addiction_Homo sapiens_hsa050332.90917053
4Oxidative phosphorylation_Homo sapiens_hsa001902.87697869
5Collecting duct acid secretion_Homo sapiens_hsa049662.58168975
6GABAergic synapse_Homo sapiens_hsa047272.53510046
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.45724775
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.45680564
9Olfactory transduction_Homo sapiens_hsa047402.38007792
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36430695
11Parkinsons disease_Homo sapiens_hsa050122.29393232
12Morphine addiction_Homo sapiens_hsa050322.27201621
13Glutamatergic synapse_Homo sapiens_hsa047242.23455944
14Circadian entrainment_Homo sapiens_hsa047132.20545074
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.16328363
16Sulfur relay system_Homo sapiens_hsa041222.09493433
17Alzheimers disease_Homo sapiens_hsa050101.96281788
18Vibrio cholerae infection_Homo sapiens_hsa051101.96096229
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94215999
20Serotonergic synapse_Homo sapiens_hsa047261.86416819
21Dopaminergic synapse_Homo sapiens_hsa047281.86117200
22Amphetamine addiction_Homo sapiens_hsa050311.85170179
23RNA polymerase_Homo sapiens_hsa030201.79257699
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77105195
25Long-term potentiation_Homo sapiens_hsa047201.74656131
26Base excision repair_Homo sapiens_hsa034101.74173214
27Biosynthesis of amino acids_Homo sapiens_hsa012301.74113168
28Fatty acid elongation_Homo sapiens_hsa000621.71871548
29DNA replication_Homo sapiens_hsa030301.70121821
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69871146
31Cardiac muscle contraction_Homo sapiens_hsa042601.62103126
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62063761
33Folate biosynthesis_Homo sapiens_hsa007901.61282048
34Salivary secretion_Homo sapiens_hsa049701.59526717
35* Axon guidance_Homo sapiens_hsa043601.57675071
36Taste transduction_Homo sapiens_hsa047421.56969868
37Cholinergic synapse_Homo sapiens_hsa047251.55869402
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54639469
39Insulin secretion_Homo sapiens_hsa049111.53485539
40Long-term depression_Homo sapiens_hsa047301.52460003
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45774694
42Carbon metabolism_Homo sapiens_hsa012001.43081115
43Gastric acid secretion_Homo sapiens_hsa049711.42719958
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39876829
45Huntingtons disease_Homo sapiens_hsa050161.38467638
46* Cocaine addiction_Homo sapiens_hsa050301.34201795
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34178056
48Ribosome_Homo sapiens_hsa030101.31124952
49Pyrimidine metabolism_Homo sapiens_hsa002401.30980084
50Pentose phosphate pathway_Homo sapiens_hsa000301.29781982
51Mismatch repair_Homo sapiens_hsa034301.26686105
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23495226
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21782384
54Fructose and mannose metabolism_Homo sapiens_hsa000511.20324626
55Phototransduction_Homo sapiens_hsa047441.18434550
56Steroid biosynthesis_Homo sapiens_hsa001001.17779522
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14093468
58Renin secretion_Homo sapiens_hsa049241.12114332
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11671643
60Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11588890
61Oxytocin signaling pathway_Homo sapiens_hsa049211.09812635
62Ether lipid metabolism_Homo sapiens_hsa005651.09678378
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09639016
64Gap junction_Homo sapiens_hsa045401.08946877
65Calcium signaling pathway_Homo sapiens_hsa040201.06002803
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05716764
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03218599
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01763972
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.99174745
70Rheumatoid arthritis_Homo sapiens_hsa053230.98069428
71ErbB signaling pathway_Homo sapiens_hsa040120.94503189
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93636357
73GnRH signaling pathway_Homo sapiens_hsa049120.92583290
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89198382
75Galactose metabolism_Homo sapiens_hsa000520.88194287
76cAMP signaling pathway_Homo sapiens_hsa040240.88179466
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85464896
78Spliceosome_Homo sapiens_hsa030400.82489352
79Arginine and proline metabolism_Homo sapiens_hsa003300.81932748
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81904842
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.79889325
82Glutathione metabolism_Homo sapiens_hsa004800.79413761
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77624462
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77458134
85Nucleotide excision repair_Homo sapiens_hsa034200.77259381
86Protein export_Homo sapiens_hsa030600.77025561
87Purine metabolism_Homo sapiens_hsa002300.75498360
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74862994
89Sulfur metabolism_Homo sapiens_hsa009200.73866832
90Phagosome_Homo sapiens_hsa041450.71922794
91Melanogenesis_Homo sapiens_hsa049160.71890462
92Metabolic pathways_Homo sapiens_hsa011000.70964920
93Sphingolipid metabolism_Homo sapiens_hsa006000.70850419
94RNA transport_Homo sapiens_hsa030130.69965124
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69200797
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.69029701
97Butanoate metabolism_Homo sapiens_hsa006500.67857610
98Pancreatic secretion_Homo sapiens_hsa049720.65983541
99N-Glycan biosynthesis_Homo sapiens_hsa005100.65381374
100Ras signaling pathway_Homo sapiens_hsa040140.65064813
101Endocytosis_Homo sapiens_hsa041440.64063791
102Basal transcription factors_Homo sapiens_hsa030220.63889636
103Homologous recombination_Homo sapiens_hsa034400.61239369
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.61142260
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60376103
106Estrogen signaling pathway_Homo sapiens_hsa049150.59869990
107Fatty acid metabolism_Homo sapiens_hsa012120.56013357
108MAPK signaling pathway_Homo sapiens_hsa040100.55257270
109Renal cell carcinoma_Homo sapiens_hsa052110.55073916
110Alcoholism_Homo sapiens_hsa050340.52783907
111Peroxisome_Homo sapiens_hsa041460.51672416
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51303792
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51178195
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50101370
115Propanoate metabolism_Homo sapiens_hsa006400.49835353
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49763312
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49417097
118Ovarian steroidogenesis_Homo sapiens_hsa049130.48562147
119Dorso-ventral axis formation_Homo sapiens_hsa043200.48335075
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.48194004
121Regulation of autophagy_Homo sapiens_hsa041400.47789096
122Oocyte meiosis_Homo sapiens_hsa041140.46636874
123Cell cycle_Homo sapiens_hsa041100.46361342
124Type II diabetes mellitus_Homo sapiens_hsa049300.46176158
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45981176
126Choline metabolism in cancer_Homo sapiens_hsa052310.45020239
127Glioma_Homo sapiens_hsa052140.43083702
128Non-homologous end-joining_Homo sapiens_hsa034500.42138228
129Fanconi anemia pathway_Homo sapiens_hsa034600.41284454
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38121735
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36448363
132Dilated cardiomyopathy_Homo sapiens_hsa054140.35641305
133Thyroid hormone synthesis_Homo sapiens_hsa049180.34916540
134Prion diseases_Homo sapiens_hsa050200.34880578
135Vitamin B6 metabolism_Homo sapiens_hsa007500.34214113
136Arginine biosynthesis_Homo sapiens_hsa002200.33804209
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33407806
138Tight junction_Homo sapiens_hsa045300.33306003
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.31948185
140Pyruvate metabolism_Homo sapiens_hsa006200.31351761
141Lysosome_Homo sapiens_hsa041420.30494923
142Phenylalanine metabolism_Homo sapiens_hsa003600.30302385
143VEGF signaling pathway_Homo sapiens_hsa043700.28965547
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27223563
145Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27053444
146beta-Alanine metabolism_Homo sapiens_hsa004100.26893059
147Rap1 signaling pathway_Homo sapiens_hsa040150.26019014
148Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24684754
149Type I diabetes mellitus_Homo sapiens_hsa049400.24338388
150Inositol phosphate metabolism_Homo sapiens_hsa005620.23960896
151Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21531847

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