CDK5R2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.92455676
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.64449101
3locomotory exploration behavior (GO:0035641)6.28255627
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.08207119
5vocalization behavior (GO:0071625)5.84192455
6synaptic vesicle exocytosis (GO:0016079)5.64085308
7glutamate secretion (GO:0014047)5.64022837
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.54154436
9* positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.41520999
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.36213331
11regulation of synaptic vesicle exocytosis (GO:2000300)5.35886718
12regulation of glutamate receptor signaling pathway (GO:1900449)5.15876831
13protein localization to synapse (GO:0035418)5.06899358
14exploration behavior (GO:0035640)4.85041490
15regulation of long-term neuronal synaptic plasticity (GO:0048169)4.81864203
16regulation of neuronal synaptic plasticity (GO:0048168)4.78078863
17dendritic spine morphogenesis (GO:0060997)4.78001796
18regulation of synaptic vesicle transport (GO:1902803)4.73726745
19regulation of synapse structural plasticity (GO:0051823)4.71143105
20neurotransmitter secretion (GO:0007269)4.63223404
21neuron cell-cell adhesion (GO:0007158)4.48508293
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.46198872
23cerebellar granule cell differentiation (GO:0021707)4.45399220
24neuronal action potential propagation (GO:0019227)4.35272372
25regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.28623547
26neurotransmitter-gated ion channel clustering (GO:0072578)4.18537405
27proline transport (GO:0015824)4.15797157
28synaptic transmission, glutamatergic (GO:0035249)4.09743217
29positive regulation of membrane potential (GO:0045838)4.08814595
30gamma-aminobutyric acid transport (GO:0015812)3.99018184
31* layer formation in cerebral cortex (GO:0021819)3.96578084
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.95168401
33L-amino acid import (GO:0043092)3.94637973
34long-term memory (GO:0007616)3.90678976
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.90438891
36glutamate receptor signaling pathway (GO:0007215)3.84911676
37regulation of dendritic spine morphogenesis (GO:0061001)3.84897861
38regulation of synapse maturation (GO:0090128)3.84843411
39cellular potassium ion homeostasis (GO:0030007)3.82624692
40potassium ion homeostasis (GO:0055075)3.81485109
41neuron-neuron synaptic transmission (GO:0007270)3.81394901
42activation of protein kinase A activity (GO:0034199)3.77864946
43auditory behavior (GO:0031223)3.71696612
44neuromuscular process controlling balance (GO:0050885)3.71338620
45regulation of postsynaptic membrane potential (GO:0060078)3.70256572
46regulation of synaptic plasticity (GO:0048167)3.69910197
47neurotransmitter transport (GO:0006836)3.69029178
48sodium ion export (GO:0071436)3.66987786
49negative regulation of dendrite morphogenesis (GO:0050774)3.65650445
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65043929
51regulation of neurotransmitter secretion (GO:0046928)3.60159320
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.56781664
53amino acid import (GO:0043090)3.56398239
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.56265372
55G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.53796362
56potassium ion import (GO:0010107)3.50518669
57positive regulation of neurotransmitter transport (GO:0051590)3.49570594
58positive regulation of neurotransmitter secretion (GO:0001956)3.49350339
59neuron recognition (GO:0008038)3.47623240
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.47053884
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.45216013
62regulation of neurotransmitter levels (GO:0001505)3.44132918
63response to auditory stimulus (GO:0010996)3.43924831
64positive regulation of synapse maturation (GO:0090129)3.43651551
65neuromuscular synaptic transmission (GO:0007274)3.42967017
66postsynaptic membrane organization (GO:0001941)3.42466355
67prepulse inhibition (GO:0060134)3.41791872
68dendritic spine organization (GO:0097061)3.38509107
69regulation of vesicle fusion (GO:0031338)3.38455087
70glycine transport (GO:0015816)3.36094494
71dendrite morphogenesis (GO:0048813)3.35528887
72synaptic vesicle endocytosis (GO:0048488)3.33933761
73transmission of nerve impulse (GO:0019226)3.33876736
74regulation of neurotransmitter transport (GO:0051588)3.31757119
75positive regulation of dendritic spine development (GO:0060999)3.29459653
76regulation of dendritic spine development (GO:0060998)3.27630987
77cellular sodium ion homeostasis (GO:0006883)3.25784506
78long-term synaptic potentiation (GO:0060291)3.25259244
79cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25195286
80regulation of synaptic transmission, glutamatergic (GO:0051966)3.22565080
81regulation of ARF protein signal transduction (GO:0032012)3.20980931
82establishment of mitochondrion localization (GO:0051654)3.19665067
83intraspecies interaction between organisms (GO:0051703)3.18707424
84social behavior (GO:0035176)3.18707424
85cell communication by electrical coupling (GO:0010644)3.16401219
86axonal fasciculation (GO:0007413)3.15239572
87membrane hyperpolarization (GO:0060081)3.14433198
88membrane depolarization (GO:0051899)3.12224442
89neuromuscular process controlling posture (GO:0050884)3.09877333
90chemosensory behavior (GO:0007635)3.09863133
91neuronal ion channel clustering (GO:0045161)3.09380339
92learning (GO:0007612)3.09374615
93vesicle transport along microtubule (GO:0047496)3.07595333
94cerebellar Purkinje cell differentiation (GO:0021702)3.06784108
95detection of calcium ion (GO:0005513)3.05582667
96presynaptic membrane organization (GO:0097090)3.04884388
97regulation of voltage-gated calcium channel activity (GO:1901385)3.03901613
98positive regulation of synaptic transmission (GO:0050806)3.02490919
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02194592
100negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02133691
101cell migration in hindbrain (GO:0021535)3.01678237
102neuromuscular process (GO:0050905)3.01557829
103regulation of synaptic transmission (GO:0050804)3.01264247
104cell differentiation in hindbrain (GO:0021533)3.00908631
105establishment of synaptic vesicle localization (GO:0097480)3.00755850
106synaptic vesicle transport (GO:0048489)3.00755850
107vesicle docking involved in exocytosis (GO:0006904)3.00682640
108serotonin metabolic process (GO:0042428)3.00459499
109innervation (GO:0060384)3.00444219
110synapse assembly (GO:0007416)2.98826600
111presynaptic membrane assembly (GO:0097105)2.98739478
112positive regulation of dendritic spine morphogenesis (GO:0061003)2.98506640
113positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.98224411
114behavioral fear response (GO:0001662)2.97754205
115behavioral defense response (GO:0002209)2.97754205
116signal release (GO:0023061)2.97704850
117dopamine receptor signaling pathway (GO:0007212)2.95102946
118membrane depolarization during action potential (GO:0086010)2.94362155
119synaptic transmission (GO:0007268)2.91972543
120gamma-aminobutyric acid signaling pathway (GO:0007214)2.90677497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.97748291
2* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17314173
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14851865
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04332122
5* RARB_27405468_Chip-Seq_BRAIN_Mouse2.98040440
6GBX2_23144817_ChIP-Seq_PC3_Human2.94853969
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.90431334
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82840497
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82840497
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75417760
11DROSHA_22980978_ChIP-Seq_HELA_Human2.71774191
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.65972419
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63380742
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59853040
15* EZH2_27304074_Chip-Seq_ESCs_Mouse2.53430332
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48755305
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48232201
18* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.43461665
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.39895416
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.38603793
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.34093759
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.28578365
23* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26923459
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22961436
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15603417
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14347072
27* EED_16625203_ChIP-ChIP_MESCs_Mouse2.12278443
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09786891
29AR_21572438_ChIP-Seq_LNCaP_Human1.92181432
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.87366524
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83704039
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69128962
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52089771
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48390644
35* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48072757
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42888426
37* RING1B_27294783_Chip-Seq_ESCs_Mouse1.42816002
38KDM2B_26808549_Chip-Seq_K562_Human1.42732641
39SMAD4_21799915_ChIP-Seq_A2780_Human1.40635823
40* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37200175
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36014624
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28532595
43EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28244761
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.25669084
45ZNF274_21170338_ChIP-Seq_K562_Hela1.25413534
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24730294
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23292977
48* RING1B_27294783_Chip-Seq_NPCs_Mouse1.22739835
49* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22449951
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21680312
51TAF15_26573619_Chip-Seq_HEK293_Human1.21289550
52AR_19668381_ChIP-Seq_PC3_Human1.20652556
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19360684
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16143284
55* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16124192
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13982424
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12409670
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10304534
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.10135908
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08272560
61* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07690511
62AR_25329375_ChIP-Seq_VCAP_Human1.06959851
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05726517
64* STAT3_23295773_ChIP-Seq_U87_Human1.05223867
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04825703
66RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04819896
67* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04404718
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.03573196
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.02985873
70P300_19829295_ChIP-Seq_ESCs_Human1.02927721
71* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01206579
72CTCF_27219007_Chip-Seq_Bcells_Human1.01146264
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00455880
74ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99843157
75* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99769686
76YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98679614
77* TP53_20018659_ChIP-ChIP_R1E_Mouse0.97246506
78* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96350294
79* TET1_21490601_ChIP-Seq_MESCs_Mouse0.96111778
80OCT4_19829295_ChIP-Seq_ESCs_Human0.95653597
81SMAD3_21741376_ChIP-Seq_ESCs_Human0.95352449
82CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94764253
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93913604
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93777173
85* CBX2_27304074_Chip-Seq_ESCs_Mouse0.93605795
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.92740221
87SMAD3_21741376_ChIP-Seq_HESCs_Human0.92393739
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92225227
89TCF4_23295773_ChIP-Seq_U87_Human0.91847098
90LXR_22292898_ChIP-Seq_THP-1_Human0.91712889
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.90707501
92RNF2_27304074_Chip-Seq_NSC_Mouse0.90368816
93AHR_22903824_ChIP-Seq_MCF-7_Human0.90189208
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89549955
95KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88728691
96* DPY_21335234_ChIP-Seq_ESCs_Mouse0.88615948
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87125399
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86976535
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86478828
100SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86414859
101PRDM14_20953172_ChIP-Seq_ESCs_Human0.84758544
102PIAS1_25552417_ChIP-Seq_VCAP_Human0.84368362
103* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84105765
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83246986
105RXR_22108803_ChIP-Seq_LS180_Human0.83241018
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82889351
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81464771
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81308118
109* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81154111
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80454606
111RUNX2_22187159_ChIP-Seq_PCA_Human0.80217016
112SMC4_20622854_ChIP-Seq_HELA_Human0.80067121
113IGF1R_20145208_ChIP-Seq_DFB_Human0.79069038
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78534087
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78391605
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.78391605
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78156482
118SMAD4_21741376_ChIP-Seq_ESCs_Human0.76816887
119* KLF4_19829295_ChIP-Seq_ESCs_Human0.76548167
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74141303
121CREB1_26743006_Chip-Seq_LNCaP_Human0.73399141
122* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.70952778
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70616720
124RUNX1_26923725_Chip-Seq_HPCs_Mouse0.69852603
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.69843604
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.69128524

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.15302805
2MP0003880_abnormal_central_pattern4.47273005
3MP0003635_abnormal_synaptic_transmissio4.34078184
4MP0004270_analgesia4.12029290
5MP0002063_abnormal_learning/memory/cond3.48651022
6MP0009745_abnormal_behavioral_response3.44190213
7MP0002822_catalepsy3.28154509
8MP0002064_seizures3.14038064
9MP0005423_abnormal_somatic_nervous3.03415710
10MP0001968_abnormal_touch/_nociception3.02377220
11MP0009046_muscle_twitch2.85794825
12MP0002572_abnormal_emotion/affect_behav2.81949935
13MP0002734_abnormal_mechanical_nocicepti2.80145119
14MP0001486_abnormal_startle_reflex2.61922889
15MP0002272_abnormal_nervous_system2.51152637
16MP0001501_abnormal_sleep_pattern2.21209954
17MP0002736_abnormal_nociception_after2.17399956
18MP0002733_abnormal_thermal_nociception2.16893943
19MP0009780_abnormal_chondrocyte_physiolo2.16070590
20MP0002735_abnormal_chemical_nociception2.08142977
21MP0001970_abnormal_pain_threshold2.05804253
22MP0001440_abnormal_grooming_behavior2.05096583
23MP0004858_abnormal_nervous_system2.03043503
24MP0003329_amyloid_beta_deposits1.95544519
25MP0002909_abnormal_adrenal_gland1.95091257
26MP0004811_abnormal_neuron_physiology1.92776784
27MP0008569_lethality_at_weaning1.86675384
28MP0003123_paternal_imprinting1.85584461
29MP0000778_abnormal_nervous_system1.81537483
30MP0002067_abnormal_sensory_capabilities1.79415282
31MP0002557_abnormal_social/conspecific_i1.77968153
32MP0004924_abnormal_behavior1.76613888
33MP0005386_behavior/neurological_phenoty1.76613888
34MP0002184_abnormal_innervation1.75184182
35MP0003879_abnormal_hair_cell1.60202769
36MP0000955_abnormal_spinal_cord1.60144289
37MP0004885_abnormal_endolymph1.53006330
38MP0001984_abnormal_olfaction1.48636728
39MP0002882_abnormal_neuron_morphology1.48390935
40MP0006276_abnormal_autonomic_nervous1.48031163
41MP0005646_abnormal_pituitary_gland1.47356081
42MP0002066_abnormal_motor_capabilities/c1.43338088
43MP0003633_abnormal_nervous_system1.39759200
44MP0001529_abnormal_vocalization1.25510331
45MP0001905_abnormal_dopamine_level1.25259676
46MP0005645_abnormal_hypothalamus_physiol1.23196350
47MP0001502_abnormal_circadian_rhythm1.18746295
48MP0003631_nervous_system_phenotype1.15531981
49MP0000569_abnormal_digit_pigmentation1.14763908
50MP0003787_abnormal_imprinting1.14628244
51MP0002152_abnormal_brain_morphology1.13116263
52MP0003121_genomic_imprinting1.11992306
53MP0003075_altered_response_to1.11967317
54MP0005551_abnormal_eye_electrophysiolog1.10411931
55MP0003283_abnormal_digestive_organ1.05876371
56MP0008961_abnormal_basal_metabolism1.05838800
57MP0008872_abnormal_physiological_respon1.05797071
58MP0004142_abnormal_muscle_tone1.05650523
59MP0008877_abnormal_DNA_methylation1.02168642
60MP0002229_neurodegeneration1.01221376
61MP0008874_decreased_physiological_sensi0.98025114
62MP0002069_abnormal_eating/drinking_beha0.97078157
63MP0003122_maternal_imprinting0.95277044
64MP0000751_myopathy0.92898953
65MP0001177_atelectasis0.90173934
66MP0002090_abnormal_vision0.89337632
67MP0005535_abnormal_body_temperature0.89092724
68MP0003634_abnormal_glial_cell0.88120926
69MP0000604_amyloidosis0.87629320
70MP0001986_abnormal_taste_sensitivity0.86322450
71MP0000013_abnormal_adipose_tissue0.83826865
72MP0005394_taste/olfaction_phenotype0.83278384
73MP0005499_abnormal_olfactory_system0.83278384
74MP0003690_abnormal_glial_cell0.83145745
75MP0001188_hyperpigmentation0.81882464
76MP0004085_abnormal_heartbeat0.81572685
77MP0000920_abnormal_myelination0.80626585
78MP0010386_abnormal_urinary_bladder0.80218286
79MP0001485_abnormal_pinna_reflex0.79745793
80MP0004145_abnormal_muscle_electrophysio0.79646070
81MP0004147_increased_porphyrin_level0.77604934
82MP0003632_abnormal_nervous_system0.77562974
83MP0005167_abnormal_blood-brain_barrier0.76177503
84MP0002752_abnormal_somatic_nervous0.75827156
85MP0004742_abnormal_vestibular_system0.75016379
86MP0000631_abnormal_neuroendocrine_gland0.73162746
87MP0002638_abnormal_pupillary_reflex0.70448795
88MP0001963_abnormal_hearing_physiology0.70397713
89MP0001346_abnormal_lacrimal_gland0.70154080
90MP0003172_abnormal_lysosome_physiology0.65888501
91MP0005409_darkened_coat_color0.65839488
92MP0004510_myositis0.65675745
93MP0002876_abnormal_thyroid_physiology0.63567122
94MP0004233_abnormal_muscle_weight0.63306090
95MP0010234_abnormal_vibrissa_follicle0.62418917
96MP0001664_abnormal_digestion0.61670704
97MP0003137_abnormal_impulse_conducting0.61100219
98MP0005623_abnormal_meninges_morphology0.60901394
99MP0003861_abnormal_nervous_system0.57106028
100MP0005187_abnormal_penis_morphology0.56725814
101MP0002082_postnatal_lethality0.55795641
102MP0010770_preweaning_lethality0.55795641
103MP0001348_abnormal_lacrimal_gland0.55614255
104MP0010768_mortality/aging0.54578765
105MP0004484_altered_response_of0.54034809
106MP0006072_abnormal_retinal_apoptosis0.52977909
107MP0001943_abnormal_respiration0.52573926
108MP0010769_abnormal_survival0.51824586
109MP0004130_abnormal_muscle_cell0.51476011
110MP0003956_abnormal_body_size0.50641700
111MP0001299_abnormal_eye_distance/0.50129989
112MP0000026_abnormal_inner_ear0.49041764
113MP0000579_abnormal_nail_morphology0.47888091
114MP0003938_abnormal_ear_development0.41220880
115MP0003183_abnormal_peptide_metabolism0.41137616

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.69864507
2Focal motor seizures (HP:0011153)6.95114961
3Visual hallucinations (HP:0002367)5.72350293
4Focal seizures (HP:0007359)5.61138069
5Epileptic encephalopathy (HP:0200134)4.57473956
6Progressive cerebellar ataxia (HP:0002073)4.08100615
7Action tremor (HP:0002345)4.02745860
8Atonic seizures (HP:0010819)3.94483903
9Supranuclear gaze palsy (HP:0000605)3.93005197
10Ankle clonus (HP:0011448)3.86000542
11Febrile seizures (HP:0002373)3.85240586
12Papilledema (HP:0001085)3.84134789
13Absence seizures (HP:0002121)3.77967702
14Generalized tonic-clonic seizures (HP:0002069)3.74128617
15Mutism (HP:0002300)3.65022410
16Poor eye contact (HP:0000817)3.60888568
17Broad-based gait (HP:0002136)3.49639747
18Depression (HP:0000716)3.47766620
19Impaired vibration sensation in the lower limbs (HP:0002166)3.46924898
20Dialeptic seizures (HP:0011146)3.42341193
21Urinary bladder sphincter dysfunction (HP:0002839)3.33674596
22Impaired social interactions (HP:0000735)3.21665747
23Abnormal social behavior (HP:0012433)3.21665747
24Anxiety (HP:0000739)3.19920334
25Torticollis (HP:0000473)3.12302687
26Postural instability (HP:0002172)3.11821505
27Dysdiadochokinesis (HP:0002075)3.05602508
28Gaze-evoked nystagmus (HP:0000640)3.02487399
29Dysmetria (HP:0001310)2.98754952
30Amblyopia (HP:0000646)2.98475155
31Abnormal eating behavior (HP:0100738)2.94875983
32Cerebral hypomyelination (HP:0006808)2.93566458
33Urinary urgency (HP:0000012)2.91453245
34Abnormality of the lower motor neuron (HP:0002366)2.90726858
35Genetic anticipation (HP:0003743)2.88062884
36Focal dystonia (HP:0004373)2.86458726
37Sleep apnea (HP:0010535)2.85043036
38Tetraplegia (HP:0002445)2.81192937
39Neurofibrillary tangles (HP:0002185)2.80222760
40Megalencephaly (HP:0001355)2.78834664
41Truncal ataxia (HP:0002078)2.77882502
42Cerebral inclusion bodies (HP:0100314)2.75414544
43Spastic gait (HP:0002064)2.70649523
44Limb dystonia (HP:0002451)2.65165282
45Impaired smooth pursuit (HP:0007772)2.61151899
46Stereotypic behavior (HP:0000733)2.61100962
47Craniofacial dystonia (HP:0012179)2.59750539
48Bradykinesia (HP:0002067)2.58348077
49Drooling (HP:0002307)2.55758306
50Excessive salivation (HP:0003781)2.55758306
51Termporal pattern (HP:0011008)2.55741585
52Insidious onset (HP:0003587)2.55741585
53Hyperventilation (HP:0002883)2.55227676
54Intention tremor (HP:0002080)2.53832688
55Ventricular fibrillation (HP:0001663)2.53370079
56Annular pancreas (HP:0001734)2.52716566
57Hemiparesis (HP:0001269)2.48716657
58Diplopia (HP:0000651)2.46570676
59Abnormality of binocular vision (HP:0011514)2.46570676
60Obstructive sleep apnea (HP:0002870)2.45247930
61Progressive inability to walk (HP:0002505)2.45052037
62Hemiplegia (HP:0002301)2.42470961
63Abnormality of the corticospinal tract (HP:0002492)2.42124335
64Insomnia (HP:0100785)2.38356341
65Amyotrophic lateral sclerosis (HP:0007354)2.37876953
66Epileptiform EEG discharges (HP:0011182)2.36715973
67EEG with generalized epileptiform discharges (HP:0011198)2.33355262
68Impaired vibratory sensation (HP:0002495)2.32818759
69Pointed chin (HP:0000307)2.29960450
70Hypsarrhythmia (HP:0002521)2.27281309
71Spastic tetraparesis (HP:0001285)2.27123060
72Lower limb muscle weakness (HP:0007340)2.26833185
73Abnormality of ocular smooth pursuit (HP:0000617)2.26284168
74Morphological abnormality of the pyramidal tract (HP:0002062)2.23597256
75Agitation (HP:0000713)2.21503323
76Scanning speech (HP:0002168)2.19506827
77Pheochromocytoma (HP:0002666)2.13324945
78Generalized myoclonic seizures (HP:0002123)2.12185669
79Absent speech (HP:0001344)2.11107501
80Status epilepticus (HP:0002133)2.10671899
81Peripheral hypomyelination (HP:0007182)2.09758151
82Polyphagia (HP:0002591)2.09127427
83Clonus (HP:0002169)2.07850460
84Fetal akinesia sequence (HP:0001989)2.07688411
85Apathy (HP:0000741)2.06921235
86Dysmetric saccades (HP:0000641)2.05600878
87Bundle branch block (HP:0011710)2.05406104
88Inability to walk (HP:0002540)2.00140591
89Ankyloglossia (HP:0010296)1.99009854
90Delusions (HP:0000746)1.98921487
91Inappropriate behavior (HP:0000719)1.98507505
92Resting tremor (HP:0002322)1.98490564
93Lower limb amyotrophy (HP:0007210)1.97712244
94Neuronal loss in central nervous system (HP:0002529)1.96101967
95Choreoathetosis (HP:0001266)1.92375730
96Incomplete penetrance (HP:0003829)1.91726762
97Rapidly progressive (HP:0003678)1.90136852
98Rigidity (HP:0002063)1.86967500
99Gait ataxia (HP:0002066)1.85749354
100Spastic tetraplegia (HP:0002510)1.84694694
101Akinesia (HP:0002304)1.84589593
102Abnormal EKG (HP:0003115)1.83503161
103CNS hypomyelination (HP:0003429)1.82910541
104Degeneration of the lateral corticospinal tracts (HP:0002314)1.82904613
105Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82904613
106Lower limb asymmetry (HP:0100559)1.81307376
107Diminished motivation (HP:0000745)1.81036576
108Neoplasm of the peripheral nervous system (HP:0100007)1.78330906
109Neuroendocrine neoplasm (HP:0100634)1.77490972
110Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75487717
111Hypoventilation (HP:0002791)1.73877445
112Hyperthyroidism (HP:0000836)1.71368141
113Increased circulating renin level (HP:0000848)1.69541496
114Failure to thrive in infancy (HP:0001531)1.69463409
115Diminished movement (HP:0002374)1.67032860
116Spinal canal stenosis (HP:0003416)1.66480326
117Unsteady gait (HP:0002317)1.62887538
118Hypoplasia of the corpus callosum (HP:0002079)1.62797826

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.51386028
2MAP3K94.24442900
3NTRK33.99091413
4MARK13.57971160
5DAPK22.95533644
6MINK12.84972700
7MAP3K42.71794938
8PAK62.59427771
9PRKD32.54912309
10KSR22.41488833
11MAP2K72.17251778
12CAMKK12.15719748
13NTRK12.10094661
14NTRK22.04002067
15MAP2K41.72431307
16DAPK11.68359715
17KSR11.61578841
18RIPK41.59830866
19* CDK51.58621242
20MAP3K121.56741332
21GRK51.53918600
22SIK21.47097357
23TAOK11.41631710
24MAP3K21.38823650
25PLK21.37486967
26LATS21.36892486
27STK381.33452720
28ARAF1.30525411
29TYRO31.28031373
30UHMK11.27889172
31CDK191.26852607
32PRKCG1.20244904
33MAPK131.18581881
34FES1.18237952
35PHKG11.16145289
36PHKG21.16145289
37PNCK1.15755290
38PRPF4B1.15271890
39TNIK1.07934578
40STK111.03158013
41CAMKK21.00239927
42CDK150.98863948
43ALK0.98823884
44CDK180.98784699
45MAP3K130.97745107
46CAMK10.97023005
47RET0.96993121
48CDK140.96426722
49CASK0.94407395
50PRKCH0.91527987
51CDK11A0.87325256
52CAMK2A0.86516246
53PAK30.83939935
54PINK10.82852989
55RAF10.81646911
56MARK20.80953065
57PKN10.79668762
58MAP3K110.76454368
59CSNK1G20.73714403
60SGK4940.72550420
61SGK2230.72550420
62LMTK20.70038282
63PDK10.68155325
64DYRK1A0.64860800
65RIPK10.64558790
66MAP3K10.63521048
67PDPK10.63499920
68BRAF0.62468607
69SGK10.61825317
70PTK2B0.61581627
71NEK10.59799579
72CAMK2B0.59787587
73PRKCZ0.59054299
74BRSK10.58977866
75DYRK20.58361421
76DAPK30.57153529
77SCYL20.56243922
78SGK30.54277612
79OXSR10.52306774
80CAMK1G0.48893779
81RPS6KA30.48875960
82FYN0.48711292
83SGK20.48282465
84TESK10.47504314
85BMPR20.46858358
86CDC42BPA0.43884310
87CAMK40.43633803
88MAP2K10.42774366
89CAMK1D0.42680163
90MAPK100.42138599
91TNK20.41034640
92RPS6KA20.40349601
93MAP3K70.37286714
94PRKCA0.37260059
95PRKCE0.37161607
96NEK60.37137773
97MAPK120.36110639
98CCNB10.35667276
99MAP3K60.34001541
100ROCK20.33799771
101DMPK0.33218337
102CAMK2G0.33172367
103MAP2K60.31867644
104CAMK2D0.31554403
105CSNK1E0.31214240
106WNK40.30849945
107PRKCB0.30584720
108MAPK80.29235937
109LIMK10.28530284
110FGR0.28203795
111PRKACA0.27454513
112ERBB20.26468945
113ICK0.25929154
114WNK10.25611968

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.34709597
2Nicotine addiction_Homo sapiens_hsa050333.21210973
3Olfactory transduction_Homo sapiens_hsa047402.99896365
4Circadian entrainment_Homo sapiens_hsa047132.64694205
5Long-term potentiation_Homo sapiens_hsa047202.61031625
6GABAergic synapse_Homo sapiens_hsa047272.59281877
7Glutamatergic synapse_Homo sapiens_hsa047242.53344197
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45642727
9Amphetamine addiction_Homo sapiens_hsa050312.43372746
10Morphine addiction_Homo sapiens_hsa050322.41276961
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.37121794
12Dopaminergic synapse_Homo sapiens_hsa047282.21375983
13Salivary secretion_Homo sapiens_hsa049702.15324801
14Insulin secretion_Homo sapiens_hsa049112.06663626
15Cholinergic synapse_Homo sapiens_hsa047252.05008787
16Gastric acid secretion_Homo sapiens_hsa049711.95552574
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88965464
18Cocaine addiction_Homo sapiens_hsa050301.78584804
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76432515
20Oxytocin signaling pathway_Homo sapiens_hsa049211.68826346
21Renin secretion_Homo sapiens_hsa049241.64648249
22Long-term depression_Homo sapiens_hsa047301.59262491
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57243756
24Serotonergic synapse_Homo sapiens_hsa047261.56648834
25Taste transduction_Homo sapiens_hsa047421.51650358
26GnRH signaling pathway_Homo sapiens_hsa049121.50425621
27Vitamin B6 metabolism_Homo sapiens_hsa007501.48975872
28Calcium signaling pathway_Homo sapiens_hsa040201.48151765
29Phototransduction_Homo sapiens_hsa047441.41675995
30Gap junction_Homo sapiens_hsa045401.41258952
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41070664
32Nitrogen metabolism_Homo sapiens_hsa009101.35245188
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33638189
34Glioma_Homo sapiens_hsa052141.28495731
35cAMP signaling pathway_Homo sapiens_hsa040241.24831306
36Type II diabetes mellitus_Homo sapiens_hsa049301.24393583
37Estrogen signaling pathway_Homo sapiens_hsa049151.22011617
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14748460
39Axon guidance_Homo sapiens_hsa043601.14709352
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13269173
41Melanogenesis_Homo sapiens_hsa049161.09906178
42Collecting duct acid secretion_Homo sapiens_hsa049661.09847416
43ErbB signaling pathway_Homo sapiens_hsa040121.08301479
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07348540
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04193173
46Oocyte meiosis_Homo sapiens_hsa041140.94046938
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.90441326
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89778474
49Dorso-ventral axis formation_Homo sapiens_hsa043200.89526076
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.89064531
51Cardiac muscle contraction_Homo sapiens_hsa042600.88890522
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81570303
53Pancreatic secretion_Homo sapiens_hsa049720.81154875
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79143831
55Thyroid hormone synthesis_Homo sapiens_hsa049180.78670517
56VEGF signaling pathway_Homo sapiens_hsa043700.76475009
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75757702
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.75648599
59Vibrio cholerae infection_Homo sapiens_hsa051100.74340363
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73204508
61Choline metabolism in cancer_Homo sapiens_hsa052310.71267599
62MAPK signaling pathway_Homo sapiens_hsa040100.69568179
63Dilated cardiomyopathy_Homo sapiens_hsa054140.69163775
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68722791
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63293145
66mTOR signaling pathway_Homo sapiens_hsa041500.63227345
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.62917810
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60633157
69Ras signaling pathway_Homo sapiens_hsa040140.59959745
70Endocytosis_Homo sapiens_hsa041440.58581512
71Rap1 signaling pathway_Homo sapiens_hsa040150.58533343
72Alcoholism_Homo sapiens_hsa050340.57998317
73Endometrial cancer_Homo sapiens_hsa052130.57994981
74Glucagon signaling pathway_Homo sapiens_hsa049220.57856869
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56065012
76Non-small cell lung cancer_Homo sapiens_hsa052230.55040110
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54919671
78Bile secretion_Homo sapiens_hsa049760.54843578
79Renal cell carcinoma_Homo sapiens_hsa052110.51453367
80Type I diabetes mellitus_Homo sapiens_hsa049400.50814134
81Prion diseases_Homo sapiens_hsa050200.49496729
82Insulin signaling pathway_Homo sapiens_hsa049100.47574993
83Alzheimers disease_Homo sapiens_hsa050100.47471569
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47034540
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45422968
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44473760
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43939551
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43694354
89Chemokine signaling pathway_Homo sapiens_hsa040620.40789825
90Inositol phosphate metabolism_Homo sapiens_hsa005620.40725080
91Wnt signaling pathway_Homo sapiens_hsa043100.40661346
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38453705
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37591684
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37513581
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35697379
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35266281
97Circadian rhythm_Homo sapiens_hsa047100.34994771
98Ovarian steroidogenesis_Homo sapiens_hsa049130.32125298
99African trypanosomiasis_Homo sapiens_hsa051430.31025140
100Colorectal cancer_Homo sapiens_hsa052100.29457331
101Prolactin signaling pathway_Homo sapiens_hsa049170.28770466
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28736287
103Arginine biosynthesis_Homo sapiens_hsa002200.28096364
104Mineral absorption_Homo sapiens_hsa049780.27848331
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.27644914
106Platelet activation_Homo sapiens_hsa046110.25891873
107Arginine and proline metabolism_Homo sapiens_hsa003300.25442654
108AMPK signaling pathway_Homo sapiens_hsa041520.23737116
109Tight junction_Homo sapiens_hsa045300.20898734
110Hippo signaling pathway_Homo sapiens_hsa043900.19971198
111Regulation of autophagy_Homo sapiens_hsa041400.17751031
112Fatty acid biosynthesis_Homo sapiens_hsa000610.15647057

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