CDK5RAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)4.53566927
2viral mRNA export from host cell nucleus (GO:0046784)4.26543267
3ribosomal small subunit assembly (GO:0000028)4.20202206
4synapsis (GO:0007129)4.17606189
5DNA deamination (GO:0045006)4.05667226
6mitochondrial RNA metabolic process (GO:0000959)4.04266150
7purine nucleobase biosynthetic process (GO:0009113)4.04064948
8telomere maintenance via semi-conservative replication (GO:0032201)4.02946376
9nucleobase biosynthetic process (GO:0046112)4.00827149
10DNA strand elongation involved in DNA replication (GO:0006271)3.98896954
11ncRNA 3-end processing (GO:0043628)3.96563151
12ribosome biogenesis (GO:0042254)3.87497290
13DNA replication initiation (GO:0006270)3.86370966
14DNA strand elongation (GO:0022616)3.81812980
15telomere maintenance via recombination (GO:0000722)3.67549450
16ribosome assembly (GO:0042255)3.66083445
17L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.65530998
18somatic hypermutation of immunoglobulin genes (GO:0016446)3.59333977
19somatic diversification of immune receptors via somatic mutation (GO:0002566)3.59333977
20regulation of mitochondrial translation (GO:0070129)3.56961735
21mitotic metaphase plate congression (GO:0007080)3.53132767
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51501935
23transcription from mitochondrial promoter (GO:0006390)3.48824277
24CENP-A containing nucleosome assembly (GO:0034080)3.47388300
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.47363706
26meiotic chromosome segregation (GO:0045132)3.45506745
27ribonucleoprotein complex biogenesis (GO:0022613)3.43133710
28chromatin remodeling at centromere (GO:0031055)3.40764266
29anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39905269
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37772851
31DNA damage response, detection of DNA damage (GO:0042769)3.35449698
32mitotic recombination (GO:0006312)3.35298331
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.34787510
34rRNA modification (GO:0000154)3.33452948
35non-recombinational repair (GO:0000726)3.32489734
36double-strand break repair via nonhomologous end joining (GO:0006303)3.32489734
37mitotic sister chromatid segregation (GO:0000070)3.32351147
38proteasome assembly (GO:0043248)3.32265309
39L-methionine salvage (GO:0071267)3.28780740
40L-methionine biosynthetic process (GO:0071265)3.28780740
41amino acid salvage (GO:0043102)3.28780740
42piRNA metabolic process (GO:0034587)3.28605908
43nucleobase-containing small molecule interconversion (GO:0015949)3.25218798
44maturation of SSU-rRNA (GO:0030490)3.24229552
45rRNA processing (GO:0006364)3.23604846
46DNA ligation (GO:0006266)3.21544000
47protein deneddylation (GO:0000338)3.19174339
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.18691086
49termination of RNA polymerase III transcription (GO:0006386)3.18691086
50mitotic spindle checkpoint (GO:0071174)3.18224670
51negative regulation of chromosome segregation (GO:0051985)3.18005022
52nucleotide-excision repair, DNA gap filling (GO:0006297)3.17503948
53maturation of 5.8S rRNA (GO:0000460)3.15845409
54IMP biosynthetic process (GO:0006188)3.15394154
55nucleotide transmembrane transport (GO:1901679)3.14005675
56regulation of cellular amino acid metabolic process (GO:0006521)3.13289438
57negative regulation of ligase activity (GO:0051352)3.13239853
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13239853
59chromosome organization involved in meiosis (GO:0070192)3.12548219
60inner mitochondrial membrane organization (GO:0007007)3.12514962
61negative regulation of mitotic sister chromatid separation (GO:2000816)3.11664062
62negative regulation of sister chromatid segregation (GO:0033046)3.11664062
63negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.11664062
64negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11664062
65negative regulation of mitotic sister chromatid segregation (GO:0033048)3.11664062
66metaphase plate congression (GO:0051310)3.11606870
67DNA replication checkpoint (GO:0000076)3.10101765
68spindle checkpoint (GO:0031577)3.09661962
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09517207
70signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.09455473
71signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.09455473
72signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.09455473
73folic acid-containing compound biosynthetic process (GO:0009396)3.09426398
74tRNA aminoacylation for protein translation (GO:0006418)3.08621084
75rRNA metabolic process (GO:0016072)3.08401420
767-methylguanosine mRNA capping (GO:0006370)3.08214641
77deoxyribonucleotide biosynthetic process (GO:0009263)3.07968890
78DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07550037
79mitotic spindle assembly checkpoint (GO:0007094)3.07477254
80histone exchange (GO:0043486)3.06574461
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06385557
82signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06385557
83mitotic chromosome condensation (GO:0007076)3.06108548
84mitochondrial respiratory chain complex assembly (GO:0033108)3.05001640
85replication fork processing (GO:0031297)3.04865781
86chaperone-mediated protein transport (GO:0072321)3.03992854
87sister chromatid segregation (GO:0000819)3.03814196
88spindle assembly checkpoint (GO:0071173)3.02645375
89male meiosis I (GO:0007141)3.02548671
90mitotic nuclear envelope disassembly (GO:0007077)3.02072258
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.01766754
92RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.00914836
93pseudouridine synthesis (GO:0001522)3.00858725
94signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00591014
95signal transduction involved in DNA damage checkpoint (GO:0072422)3.00591014
96cellular component biogenesis (GO:0044085)3.00393138
97amino acid activation (GO:0043038)3.00328848
98tRNA aminoacylation (GO:0043039)3.00328848
99ribosomal small subunit biogenesis (GO:0042274)2.99882074
1007-methylguanosine RNA capping (GO:0009452)2.99420867
101RNA capping (GO:0036260)2.99420867
102telomere maintenance via telomere lengthening (GO:0010833)2.99370864
103nuclear pore complex assembly (GO:0051292)2.98887203
104spliceosomal snRNP assembly (GO:0000387)2.98001387
105ribosomal large subunit biogenesis (GO:0042273)2.97425954
106positive regulation of ligase activity (GO:0051351)2.97230221
107kinetochore organization (GO:0051383)2.96595056
108mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95206847
109signal transduction involved in cell cycle checkpoint (GO:0072395)2.95154852
110kinetochore assembly (GO:0051382)2.94364402
111resolution of meiotic recombination intermediates (GO:0000712)2.94193201
112cytochrome complex assembly (GO:0017004)2.94171053
113GMP metabolic process (GO:0046037)2.94160817
114DNA unwinding involved in DNA replication (GO:0006268)2.91621415
115mitochondrial DNA replication (GO:0006264)2.91223462
116nuclear pore organization (GO:0006999)2.91168405
117protein localization to kinetochore (GO:0034501)2.90798410
118rRNA methylation (GO:0031167)2.90770241
119respiratory chain complex IV assembly (GO:0008535)2.90566491
120meiosis I (GO:0007127)2.90264991
121protein-cofactor linkage (GO:0018065)2.89775060
122oxidative phosphorylation (GO:0006119)2.89725519
123cell cycle G1/S phase transition (GO:0044843)2.88191967
124G1/S transition of mitotic cell cycle (GO:0000082)2.88191967
125antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.87225160
126tRNA methylation (GO:0030488)2.86370572
127protein complex biogenesis (GO:0070271)2.85877957
128cullin deneddylation (GO:0010388)2.85669460
129establishment of viral latency (GO:0019043)2.85650535
130deoxyribose phosphate biosynthetic process (GO:0046385)2.85408791
1312-deoxyribonucleotide biosynthetic process (GO:0009265)2.85408791
132peptidyl-histidine modification (GO:0018202)2.85103327
133methionine biosynthetic process (GO:0009086)2.85100261
134mismatch repair (GO:0006298)2.84882169
135base-excision repair (GO:0006284)2.84668308
136transcription-coupled nucleotide-excision repair (GO:0006283)2.83524905
137DNA replication-independent nucleosome organization (GO:0034724)2.81848036
138DNA replication-independent nucleosome assembly (GO:0006336)2.81848036
139GDP-mannose metabolic process (GO:0019673)2.81131369
140translation (GO:0006412)2.80901892
141folic acid metabolic process (GO:0046655)2.80617866
142establishment of protein localization to mitochondrial membrane (GO:0090151)2.78854819
143mitochondrial respiratory chain complex I assembly (GO:0032981)2.78783124
144NADH dehydrogenase complex assembly (GO:0010257)2.78783124
145mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78783124
146* ncRNA processing (GO:0034470)2.78698046
147IMP metabolic process (GO:0046040)2.78545539
148establishment of integrated proviral latency (GO:0075713)2.77974804
149viral transcription (GO:0019083)2.77652347
150translational initiation (GO:0006413)2.77168929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.83194651
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.97505237
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.95065724
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57586186
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.57155830
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.52943568
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.52872578
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.45942706
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.17806177
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.92060965
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80994629
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79309327
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68925572
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66395895
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62187128
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56622879
17* VDR_23849224_ChIP-Seq_CD4+_Human2.52610010
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49994474
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46836552
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.44311874
21FOXP3_21729870_ChIP-Seq_TREG_Human2.37734731
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33193172
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28904904
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.27049926
25* SRF_21415370_ChIP-Seq_HL-1_Mouse2.25927878
26DCP1A_22483619_ChIP-Seq_HELA_Human2.23271212
27* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17147504
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14574047
29YY1_21170310_ChIP-Seq_MESCs_Mouse2.12667758
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.10098377
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04066865
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02984516
33AR_21909140_ChIP-Seq_LNCAP_Human2.00479819
34XRN2_22483619_ChIP-Seq_HELA_Human1.97856925
35ELK1_19687146_ChIP-ChIP_HELA_Human1.96659017
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95480173
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88778642
38* GABP_19822575_ChIP-Seq_HepG2_Human1.88067226
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82604492
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81831072
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79273807
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77573119
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74563403
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68472708
45TTF2_22483619_ChIP-Seq_HELA_Human1.67494511
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67073937
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64462720
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.60990818
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59987576
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59891630
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56979443
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56907826
53CIITA_25753668_ChIP-Seq_RAJI_Human1.56841176
54KDM5A_27292631_Chip-Seq_BREAST_Human1.55215744
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55072605
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54788371
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.48599926
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47582428
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44875433
60GATA1_22025678_ChIP-Seq_K562_Human1.37075353
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36865368
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34167494
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33802628
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31388150
65ZNF274_21170338_ChIP-Seq_K562_Hela1.29604332
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28316235
67* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24973433
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24847180
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23554077
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18928383
71TFEB_21752829_ChIP-Seq_HELA_Human1.17797876
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14999235
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14643961
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13361202
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13279592
76MYC_18940864_ChIP-ChIP_HL60_Human1.13159828
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06072310
78* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03751962
79SPI1_23547873_ChIP-Seq_NB4_Human1.03498284
80* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02198042
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01842194
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00578077
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00022783
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.99413922
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97908262
86EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97424841
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97099420
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96956260
89IRF8_22096565_ChIP-ChIP_GC-B_Human0.96283427
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92267543
91ZNF263_19887448_ChIP-Seq_K562_Human0.91708648
92* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89126028
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.88997622
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87843950
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86680905
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84256213
97EGR1_19374776_ChIP-ChIP_THP-1_Human0.83907023
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.81248005
99SOX17_20123909_ChIP-Seq_XEN_Mouse0.80255827
100SALL1_21062744_ChIP-ChIP_HESCs_Human0.77817698
101* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77278639
102* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76701887
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75301595
104TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73435702
105CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72332326
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71118505
107SOX2_16153702_ChIP-ChIP_HESCs_Human0.68309966
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.67603362
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.66859746
110IRF1_19129219_ChIP-ChIP_H3396_Human0.65830744
111IGF1R_20145208_ChIP-Seq_DFB_Human0.65403071
112MYC_22102868_ChIP-Seq_BL_Human0.64940108
113FOXP1_21924763_ChIP-Seq_HESCs_Human0.64330694
114* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.63634949
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.63137625
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62090424
117SOX2_18555785_ChIP-Seq_MESCs_Mouse0.61987650
118PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.61096522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.66349355
2MP0003693_abnormal_embryo_hatching4.19466237
3MP0010094_abnormal_chromosome_stability3.82104135
4MP0008057_abnormal_DNA_replication3.69355634
5MP0008058_abnormal_DNA_repair3.33835934
6MP0003111_abnormal_nucleus_morphology3.17056351
7MP0004957_abnormal_blastocyst_morpholog3.15304104
8MP0003077_abnormal_cell_cycle3.08153936
9MP0004147_increased_porphyrin_level2.25165392
10MP0008007_abnormal_cellular_replicative2.14386832
11MP0006036_abnormal_mitochondrial_physio2.10842514
12MP0002396_abnormal_hematopoietic_system2.05274953
13MP0003186_abnormal_redox_activity2.04916517
14MP0003121_genomic_imprinting2.02948355
15MP0003567_abnormal_fetal_cardiomyocyte1.85028402
16MP0008877_abnormal_DNA_methylation1.84220589
17MP0009697_abnormal_copulation1.76500541
18MP0005670_abnormal_white_adipose1.72181064
19MP0003646_muscle_fatigue1.71354818
20MP0001764_abnormal_homeostasis1.69134969
21MP0001529_abnormal_vocalization1.68429016
22MP0005266_abnormal_metabolism1.63156364
23MP0005365_abnormal_bile_salt1.63049028
24MP0003718_maternal_effect1.58210783
25MP0005408_hypopigmentation1.55655628
26MP0001730_embryonic_growth_arrest1.55650034
27MP0004264_abnormal_extraembryonic_tissu1.55386082
28MP0003786_premature_aging1.53742303
29MP0003763_abnormal_thymus_physiology1.52887523
30MP0008875_abnormal_xenobiotic_pharmacok1.52699347
31MP0006035_abnormal_mitochondrial_morpho1.51831176
32MP0006292_abnormal_olfactory_placode1.46989613
33MP0000350_abnormal_cell_proliferation1.44247364
34MP0003195_calcinosis1.41695465
35MP0008932_abnormal_embryonic_tissue1.41655389
36MP0003122_maternal_imprinting1.40319627
37MP0002132_abnormal_respiratory_system1.34225585
38MP0001835_abnormal_antigen_presentation1.32580119
39MP0002837_dystrophic_cardiac_calcinosis1.31113854
40MP0002938_white_spotting1.30960859
41MP0008995_early_reproductive_senescence1.30567455
42MP0001346_abnormal_lacrimal_gland1.29893130
43MP0001293_anophthalmia1.28997206
44MP0003698_abnormal_male_reproductive1.28120079
45MP0009333_abnormal_splenocyte_physiolog1.26920567
46MP0000313_abnormal_cell_death1.26843652
47MP0003183_abnormal_peptide_metabolism1.25664924
48MP0002876_abnormal_thyroid_physiology1.25434398
49MP0000015_abnormal_ear_pigmentation1.23429810
50MP0002019_abnormal_tumor_incidence1.23034968
51MP0005499_abnormal_olfactory_system1.18704364
52MP0005394_taste/olfaction_phenotype1.18704364
53MP0001853_heart_inflammation1.18460926
54MP0008260_abnormal_autophagy1.18149233
55MP0002398_abnormal_bone_marrow1.17325360
56MP0003136_yellow_coat_color1.15070992
57MP0000566_synostosis1.14283571
58MP0004233_abnormal_muscle_weight1.14273684
59MP0005397_hematopoietic_system_phenotyp1.14041014
60MP0001545_abnormal_hematopoietic_system1.14041014
61MP0003787_abnormal_imprinting1.13113085
62MP0002822_catalepsy1.12542372
63MP0000358_abnormal_cell_content/1.12426264
64MP0002160_abnormal_reproductive_system1.09500676
65MP0002139_abnormal_hepatobiliary_system1.09055509
66MP0010030_abnormal_orbit_morphology1.08316124
67MP0003123_paternal_imprinting1.07209629
68MP0000490_abnormal_crypts_of1.05600563
69MP0001661_extended_life_span1.05272107
70MP0000685_abnormal_immune_system1.04506184
71MP0002722_abnormal_immune_system1.04241020
72MP0000689_abnormal_spleen_morphology1.04218874
73MP0005085_abnormal_gallbladder_physiolo1.02117379
74MP0002163_abnormal_gland_morphology1.00542409
75MP0010352_gastrointestinal_tract_polyps1.00537206
76MP0002429_abnormal_blood_cell1.00412075
77MP0003984_embryonic_growth_retardation1.00129237
78MP0002084_abnormal_developmental_patter0.98433709
79MP0000703_abnormal_thymus_morphology0.98208828
80MP0003221_abnormal_cardiomyocyte_apopto0.97957439
81MP0002088_abnormal_embryonic_growth/wei0.97057649
82MP0005376_homeostasis/metabolism_phenot0.96800390
83MP0002210_abnormal_sex_determination0.95127954
84MP0002080_prenatal_lethality0.93979199
85MP0000716_abnormal_immune_system0.93387010
86MP0001929_abnormal_gametogenesis0.91963437
87MP0002161_abnormal_fertility/fecundity0.91413878
88MP0005075_abnormal_melanosome_morpholog0.90657572
89MP0002085_abnormal_embryonic_tissue0.89235060
90MP0005379_endocrine/exocrine_gland_phen0.88648458
91MP0003656_abnormal_erythrocyte_physiolo0.88566465
92MP0002234_abnormal_pharynx_morphology0.88125931
93MP0008789_abnormal_olfactory_epithelium0.87923401
94MP0001986_abnormal_taste_sensitivity0.87487190
95MP0009379_abnormal_foot_pigmentation0.87445493
96MP0001800_abnormal_humoral_immune0.87128136
97MP0006072_abnormal_retinal_apoptosis0.87020133
98MP0005084_abnormal_gallbladder_morpholo0.86920901
99MP0001145_abnormal_male_reproductive0.86799947
100MP0002148_abnormal_hypersensitivity_rea0.85942373
101MP0005410_abnormal_fertilization0.85020511
102MP0001873_stomach_inflammation0.84932495
103MP0005451_abnormal_body_composition0.84751881
104MP0002127_abnormal_cardiovascular_syste0.84341024
105MP0005319_abnormal_enzyme/_coenzyme0.84267118
106MP0002095_abnormal_skin_pigmentation0.84257977
107MP0009785_altered_susceptibility_to0.84233720
108MP0003950_abnormal_plasma_membrane0.83590092
109MP0001697_abnormal_embryo_size0.82710605
110MP0001119_abnormal_female_reproductive0.82441430
111MP0005389_reproductive_system_phenotype0.82113703
112MP0005395_other_phenotype0.81763272
113MP0010307_abnormal_tumor_latency0.81664062
114MP0002102_abnormal_ear_morphology0.81446301
115MP0005083_abnormal_biliary_tract0.80337141
116MP0001984_abnormal_olfaction0.79873112
117MP0002420_abnormal_adaptive_immunity0.79595652
118MP0003699_abnormal_female_reproductive0.79502144
119MP0000647_abnormal_sebaceous_gland0.79499800
120MP0000653_abnormal_sex_gland0.79167466
121MP0005384_cellular_phenotype0.78423391
122MP0005671_abnormal_response_to0.78360223
123MP0005621_abnormal_cell_physiology0.78128296
124MP0003943_abnormal_hepatobiliary_system0.77810022
125MP0002269_muscular_atrophy0.77546581
126MP0005360_urolithiasis0.77500559
127MP0003878_abnormal_ear_physiology0.76750687
128MP0005377_hearing/vestibular/ear_phenot0.76750687
129MP0001819_abnormal_immune_cell0.76708104
130MP0005636_abnormal_mineral_homeostasis0.76573949
131MP0001672_abnormal_embryogenesis/_devel0.76410619
132MP0005380_embryogenesis_phenotype0.76410619
133MP0004808_abnormal_hematopoietic_stem0.75941279
134MP0008469_abnormal_protein_level0.74904599
135MP0002736_abnormal_nociception_after0.74464988
136MP0005332_abnormal_amino_acid0.74073306
137MP0000749_muscle_degeneration0.73698732
138MP0000372_irregular_coat_pigmentation0.73552810
139MP0000598_abnormal_liver_morphology0.73317690
140MP0009672_abnormal_birth_weight0.72767809
141MP0000427_abnormal_hair_cycle0.69303355
142MP0003937_abnormal_limbs/digits/tail_de0.63415763
143MP0005253_abnormal_eye_physiology0.63149545
144MP0001324_abnormal_eye_pigmentation0.63066093
145MP0004197_abnormal_fetal_growth/weight/0.61483095
146MP0002075_abnormal_coat/hair_pigmentati0.60951661
147MP0000631_abnormal_neuroendocrine_gland0.57361391
148MP0002254_reproductive_system_inflammat0.57310021
149MP0005174_abnormal_tail_pigmentation0.57064217
150MP0000371_diluted_coat_color0.56334338

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.82494125
2Nausea (HP:0002018)3.66660073
3Degeneration of anterior horn cells (HP:0002398)3.57899144
4Abnormality of the anterior horn cell (HP:0006802)3.57899144
5Renal cortical cysts (HP:0000803)3.40291908
6Hepatic necrosis (HP:0002605)3.36514747
7Increased serum pyruvate (HP:0003542)3.24186493
8Abnormality of glycolysis (HP:0004366)3.24186493
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.20018235
10Abnormality of alanine metabolism (HP:0010916)3.20018235
11Hyperalaninemia (HP:0003348)3.20018235
12Increased hepatocellular lipid droplets (HP:0006565)3.19768772
13Lipid accumulation in hepatocytes (HP:0006561)3.18606963
14Bile duct proliferation (HP:0001408)3.18085151
15Abnormal biliary tract physiology (HP:0012439)3.18085151
16Increased CSF lactate (HP:0002490)3.14195213
17Reticulocytopenia (HP:0001896)3.12358980
18Acute necrotizing encephalopathy (HP:0006965)3.05156576
19Mitochondrial inheritance (HP:0001427)3.00848334
20Increased serum lactate (HP:0002151)2.99103881
21Generalized aminoaciduria (HP:0002909)2.97266352
22Oral leukoplakia (HP:0002745)2.96556100
23Abnormality of the heme biosynthetic pathway (HP:0010472)2.92109646
24Abnormal mitochondria in muscle tissue (HP:0008316)2.89480305
25Acute encephalopathy (HP:0006846)2.89382739
26Meckel diverticulum (HP:0002245)2.85872890
27Lactic acidosis (HP:0003128)2.84069718
28Hypoglycemic coma (HP:0001325)2.82403962
29Hepatocellular necrosis (HP:0001404)2.82046702
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.79558338
31Abnormal number of erythroid precursors (HP:0012131)2.77381983
32Abnormality of the ileum (HP:0001549)2.74184557
33Exertional dyspnea (HP:0002875)2.72525411
34Thrombocytosis (HP:0001894)2.70906727
35Breast hypoplasia (HP:0003187)2.70137908
36Abnormality of cells of the erythroid lineage (HP:0012130)2.69971252
37Rough bone trabeculation (HP:0100670)2.66968910
38Abnormality of the labia minora (HP:0012880)2.63605643
39Colon cancer (HP:0003003)2.60485733
40Pancreatic cysts (HP:0001737)2.60429708
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59777099
42Volvulus (HP:0002580)2.58796066
43Abnormality of pyrimidine metabolism (HP:0004353)2.58260715
44Aplastic anemia (HP:0001915)2.54347882
45Chromsome breakage (HP:0040012)2.54074060
46Increased intramyocellular lipid droplets (HP:0012240)2.54030069
47Pancreatic fibrosis (HP:0100732)2.53030101
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.50539694
49Hypoplastic pelvis (HP:0008839)2.49841421
50Abnormality of lateral ventricle (HP:0030047)2.49494085
5111 pairs of ribs (HP:0000878)2.48034851
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.45387113
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.45387113
543-Methylglutaconic aciduria (HP:0003535)2.42755753
55Type I transferrin isoform profile (HP:0003642)2.42429151
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41092458
57Increased muscle lipid content (HP:0009058)2.40642548
58Spinal muscular atrophy (HP:0007269)2.40295566
59Abnormality of fatty-acid metabolism (HP:0004359)2.39747567
60Ependymoma (HP:0002888)2.38405675
61Exercise intolerance (HP:0003546)2.38370246
62Cerebral edema (HP:0002181)2.38302208
63Abnormal protein glycosylation (HP:0012346)2.35512320
64Abnormal glycosylation (HP:0012345)2.35512320
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35512320
66Abnormal protein N-linked glycosylation (HP:0012347)2.35512320
67Progressive macrocephaly (HP:0004481)2.34647015
68Pancytopenia (HP:0001876)2.33272391
69Progressive muscle weakness (HP:0003323)2.28287282
70Abnormality of the renal cortex (HP:0011035)2.26558565
71Cerebral hypomyelination (HP:0006808)2.25379729
72Dicarboxylic aciduria (HP:0003215)2.22957150
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22957150
74Microvesicular hepatic steatosis (HP:0001414)2.21974543
75Tongue fasciculations (HP:0001308)2.21680378
76Respiratory difficulties (HP:0002880)2.20922071
77Agnosia (HP:0010524)2.20556268
78Methylmalonic aciduria (HP:0012120)2.20480845
79Abnormality of serum amino acid levels (HP:0003112)2.20263726
80Palpitations (HP:0001962)2.19689993
81IgM deficiency (HP:0002850)2.19388021
82Renal Fanconi syndrome (HP:0001994)2.18894998
83Progressive external ophthalmoplegia (HP:0000590)2.18891563
84Hyperglycinemia (HP:0002154)2.18457462
85Tubulointerstitial nephritis (HP:0001970)2.17568851
86Methylmalonic acidemia (HP:0002912)2.16117550
87Sloping forehead (HP:0000340)2.15764181
88Abnormality of methionine metabolism (HP:0010901)2.14630049
89Small intestinal stenosis (HP:0012848)2.12270231
90Duodenal stenosis (HP:0100867)2.12270231
91Abnormal trabecular bone morphology (HP:0100671)2.11629847
92CNS hypomyelination (HP:0003429)2.10830290
93Ectopic kidney (HP:0000086)2.08839897
94Premature graying of hair (HP:0002216)2.08506072
95Pallor (HP:0000980)2.07846783
96Abnormality of midbrain morphology (HP:0002418)2.06117815
97Molar tooth sign on MRI (HP:0002419)2.06117815
98Macrocytic anemia (HP:0001972)2.04203712
99Bone marrow hypocellularity (HP:0005528)2.03325483
100Type 2 muscle fiber atrophy (HP:0003554)2.02727252
101True hermaphroditism (HP:0010459)2.02256870
102Hypobetalipoproteinemia (HP:0003563)2.01817439
103Testicular atrophy (HP:0000029)1.99219159
104Leukodystrophy (HP:0002415)1.98049600
105Abnormality of urine glucose concentration (HP:0011016)1.97543626
106Glycosuria (HP:0003076)1.97543626
107Retinal dysplasia (HP:0007973)1.97531393
108Myelodysplasia (HP:0002863)1.97461657
109Muscle fibrillation (HP:0010546)1.97176302
110Unsteady gait (HP:0002317)1.96550281
111Brushfield spots (HP:0001088)1.94812671
112Hyperglycinuria (HP:0003108)1.94555526
113Abnormal spermatogenesis (HP:0008669)1.93511939
114Lethargy (HP:0001254)1.93433479
115Respiratory failure (HP:0002878)1.92554873
116Supernumerary spleens (HP:0009799)1.91235138
117Nephronophthisis (HP:0000090)1.90766076
118Absent radius (HP:0003974)1.89311407
119Abnormality of glycine metabolism (HP:0010895)1.88773033
120Abnormality of serine family amino acid metabolism (HP:0010894)1.88773033
121Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.88697356
122Preaxial hand polydactyly (HP:0001177)1.87645411
123Abnormality of the preputium (HP:0100587)1.87163459
124Increased nuchal translucency (HP:0010880)1.86128435
125Cellular immunodeficiency (HP:0005374)1.85937361
126Muscle fiber atrophy (HP:0100295)1.85865421
127Microretrognathia (HP:0000308)1.84952504
128Absent thumb (HP:0009777)1.84253566
129Aplasia involving forearm bones (HP:0009822)1.83552638
130Absent forearm bone (HP:0003953)1.83552638
131Ragged-red muscle fibers (HP:0003200)1.82351613
132Abnormal lung lobation (HP:0002101)1.81817266
133Hypothermia (HP:0002045)1.80667093
134Abnormality of the renal medulla (HP:0100957)1.80486205
135Adrenal hypoplasia (HP:0000835)1.80140355
136CNS demyelination (HP:0007305)1.80080430
137Optic disc pallor (HP:0000543)1.79651080
138Impulsivity (HP:0100710)1.79164983
139Duplicated collecting system (HP:0000081)1.78020486
140Ileus (HP:0002595)1.77819528
141Horseshoe kidney (HP:0000085)1.77506627
142Premature ovarian failure (HP:0008209)1.77435135
143Female pseudohermaphroditism (HP:0010458)1.77428498
144Abnormality of chromosome stability (HP:0003220)1.76843036
145Proximal tubulopathy (HP:0000114)1.76603218
146Abnormality of the duodenum (HP:0002246)1.76540357
147Pancreatic islet-cell hyperplasia (HP:0004510)1.76450505
148Secondary amenorrhea (HP:0000869)1.76163372
149Abnormality of sulfur amino acid metabolism (HP:0004339)1.74641331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.41608558
2STK164.09375226
3EIF2AK13.75181271
4IRAK43.64954035
5BUB13.33809806
6TSSK63.19529954
7WEE13.08758317
8VRK12.85595216
9NME22.80179544
10VRK22.70831340
11PBK2.65007789
12SRPK12.42646475
13EIF2AK32.29116999
14ZAK2.21144106
15TIE12.11270137
16TTK1.84815277
17MAP2K31.79192563
18PDK21.78689429
19PASK1.78345864
20TRIM281.75633443
21BRSK21.74564630
22CDC71.70206350
23PLK31.69761709
24PIM21.64052497
25PLK11.63114037
26CDK191.48604479
27PLK41.46776882
28MAP4K11.44028210
29TEC1.43317008
30CCNB11.42336960
31PNCK1.42311729
32FLT31.36932129
33NEK11.32310003
34MKNK21.32163485
35ATR1.32063933
36MAP3K31.27511480
37MAP2K61.26102120
38MAP3K61.23639193
39BMPR21.23509423
40IRAK31.16717662
41AURKB1.16599321
42MKNK11.16263457
43NUAK11.15404225
44RPS6KB21.14975493
45DYRK31.13754153
46BCKDK1.12475962
47CSNK1G31.09355038
48CHEK21.06460459
49AURKA1.04832695
50CSNK1G10.99324717
51CSNK1A1L0.98709463
52PRKCI0.96768616
53TAOK20.94882619
54NEK20.94690344
55MST40.93775610
56EIF2AK20.92097049
57BMPR1B0.91793568
58PIM10.91590210
59ZAP700.90367025
60TXK0.88707734
61STK100.86712085
62CDK40.86242927
63ACVR1B0.86175990
64NME10.82997193
65AKT30.82690087
66PLK20.77587990
67CDK70.76513664
68TGFBR10.74876643
69EPHA20.74452098
70MARK30.74143043
71CSNK1G20.73985256
72CDK80.72674669
73STK40.71616377
74PINK10.71473401
75JAK30.70077343
76NLK0.68639647
77CLK10.67574132
78BRSK10.67267801
79CHEK10.67208329
80CSNK2A10.66944437
81TESK20.66316867
82CSNK2A20.65423446
83BRAF0.64150632
84WNK40.61705524
85ATM0.58293413
86PDK40.57123908
87PDK30.57123908
88IKBKB0.56843550
89MAPKAPK30.55738044
90DAPK10.54873745
91MAP3K50.54816701
92MAP3K40.54760839
93BTK0.53645589
94OXSR10.53614123
95TYK20.52837254
96TLK10.51826426
97KDR0.51709511
98MAP3K140.51151926
99SCYL20.51106033
100WNK30.51094025
101DYRK20.51045552
102RPS6KA40.50595229
103OBSCN0.48043963
104KIT0.47340230
105FRK0.47188846
106CSNK1E0.47128120
107MAP3K80.47113505
108BRD40.46111439
109MAP3K120.44485443
110MYLK0.43834976
111ALK0.43655011
112RPS6KC10.43043130
113RPS6KL10.43043130
114PIK3CG0.42879536
115PRKDC0.42051033
116MAPK130.41520594
117STK38L0.40622668
118CDK20.39512201
119GRK60.39454185
120ERBB40.39336598
121TAOK30.38515414
122INSRR0.36849292
123RPS6KA60.36566679
124PAK10.35811768
125MELK0.35790114
126GRK70.35193306
127CDK30.32770793
128ADRBK20.32595149
129MAPK110.31957065
130MUSK0.31768581
131SYK0.31424269
132CDK10.31226677
133BMX0.29919175
134TNIK0.28442887
135RPS6KA50.27081069
136FGFR10.25528053
137MST1R0.25482980
138PRKCD0.24949618
139AKT20.24332007
140EEF2K0.22817443
141CSNK1A10.22083935
142LRRK20.22038605
143CDK90.20590678

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.94856870
2DNA replication_Homo sapiens_hsa030303.93490256
3Mismatch repair_Homo sapiens_hsa034303.65643495
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.21668074
5Ribosome_Homo sapiens_hsa030103.09689778
6RNA polymerase_Homo sapiens_hsa030203.07052864
7RNA transport_Homo sapiens_hsa030132.59495148
8Homologous recombination_Homo sapiens_hsa034402.55330639
9Base excision repair_Homo sapiens_hsa034102.47982123
10Pyrimidine metabolism_Homo sapiens_hsa002402.39916498
11Spliceosome_Homo sapiens_hsa030402.20622207
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16147486
13One carbon pool by folate_Homo sapiens_hsa006702.13989423
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06607159
15Nucleotide excision repair_Homo sapiens_hsa034202.06189324
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95228695
17Fanconi anemia pathway_Homo sapiens_hsa034601.92126615
18Non-homologous end-joining_Homo sapiens_hsa034501.86597273
19Caffeine metabolism_Homo sapiens_hsa002321.83490299
20Cell cycle_Homo sapiens_hsa041101.80762720
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.71838239
22Protein export_Homo sapiens_hsa030601.67801951
23Oxidative phosphorylation_Homo sapiens_hsa001901.63970418
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.63261105
25RNA degradation_Homo sapiens_hsa030181.62710804
26Steroid biosynthesis_Homo sapiens_hsa001001.61398355
27Parkinsons disease_Homo sapiens_hsa050121.57725156
28Basal transcription factors_Homo sapiens_hsa030221.49196415
29Purine metabolism_Homo sapiens_hsa002301.47992016
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.46831565
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42524666
32Fatty acid elongation_Homo sapiens_hsa000621.35576206
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28904939
34Folate biosynthesis_Homo sapiens_hsa007901.25768389
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24918541
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21181907
37Pentose phosphate pathway_Homo sapiens_hsa000301.20082539
38Huntingtons disease_Homo sapiens_hsa050161.19083771
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16628799
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14698136
41Biosynthesis of amino acids_Homo sapiens_hsa012301.14687752
42Sulfur relay system_Homo sapiens_hsa041221.13850663
43Carbon metabolism_Homo sapiens_hsa012001.10815819
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10636352
45Selenocompound metabolism_Homo sapiens_hsa004501.07710823
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99273428
47p53 signaling pathway_Homo sapiens_hsa041150.96208896
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95003543
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93157965
50Epstein-Barr virus infection_Homo sapiens_hsa051690.91582363
51Butanoate metabolism_Homo sapiens_hsa006500.86657805
52Glutathione metabolism_Homo sapiens_hsa004800.84388216
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83706605
54Pyruvate metabolism_Homo sapiens_hsa006200.82723852
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.80951691
56Propanoate metabolism_Homo sapiens_hsa006400.80524841
57Oocyte meiosis_Homo sapiens_hsa041140.80273016
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80190186
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78808201
60Vitamin B6 metabolism_Homo sapiens_hsa007500.78261172
61Alzheimers disease_Homo sapiens_hsa050100.78142927
62Fructose and mannose metabolism_Homo sapiens_hsa000510.77459477
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76303798
64Fatty acid metabolism_Homo sapiens_hsa012120.74355614
65Peroxisome_Homo sapiens_hsa041460.73944578
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73330267
67Antigen processing and presentation_Homo sapiens_hsa046120.72049483
68Chemical carcinogenesis_Homo sapiens_hsa052040.69900779
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68559484
70Metabolic pathways_Homo sapiens_hsa011000.65782230
71Sulfur metabolism_Homo sapiens_hsa009200.64068775
72Galactose metabolism_Homo sapiens_hsa000520.63690723
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62783405
74Tryptophan metabolism_Homo sapiens_hsa003800.61422305
75Regulation of autophagy_Homo sapiens_hsa041400.60652943
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60516316
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.60211951
78Fatty acid degradation_Homo sapiens_hsa000710.59755575
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59527594
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.55854897
81Cardiac muscle contraction_Homo sapiens_hsa042600.53800823
82mRNA surveillance pathway_Homo sapiens_hsa030150.53294894
83Herpes simplex infection_Homo sapiens_hsa051680.52777582
84Retinol metabolism_Homo sapiens_hsa008300.52708051
85Primary immunodeficiency_Homo sapiens_hsa053400.52574933
86Other glycan degradation_Homo sapiens_hsa005110.51572600
87Systemic lupus erythematosus_Homo sapiens_hsa053220.49807199
88Lysine degradation_Homo sapiens_hsa003100.49186826
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47237195
90Tyrosine metabolism_Homo sapiens_hsa003500.44263086
91Phenylalanine metabolism_Homo sapiens_hsa003600.43507798
92Legionellosis_Homo sapiens_hsa051340.39192854
93Measles_Homo sapiens_hsa051620.37408102
94Arginine and proline metabolism_Homo sapiens_hsa003300.36206130
95Starch and sucrose metabolism_Homo sapiens_hsa005000.34775181
96beta-Alanine metabolism_Homo sapiens_hsa004100.29866608
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.29583030
98Viral carcinogenesis_Homo sapiens_hsa052030.28293445
99N-Glycan biosynthesis_Homo sapiens_hsa005100.28024937
100Renin-angiotensin system_Homo sapiens_hsa046140.27869156
101Arginine biosynthesis_Homo sapiens_hsa002200.25786545
102Collecting duct acid secretion_Homo sapiens_hsa049660.24929433
103Histidine metabolism_Homo sapiens_hsa003400.24905528
104Ether lipid metabolism_Homo sapiens_hsa005650.23818781
105Fat digestion and absorption_Homo sapiens_hsa049750.22734152
106Allograft rejection_Homo sapiens_hsa053300.20749392
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20162502
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.19514126
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17526952
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17403272
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.16740985
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15944826
113Phototransduction_Homo sapiens_hsa047440.14846312
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14419760
115Leishmaniasis_Homo sapiens_hsa051400.14042587
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.13773984
117HTLV-I infection_Homo sapiens_hsa051660.13561979
118Vitamin digestion and absorption_Homo sapiens_hsa049770.13073314
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11658935
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11261025
121Nitrogen metabolism_Homo sapiens_hsa009100.08427264
122Alcoholism_Homo sapiens_hsa050340.03782570
123Linoleic acid metabolism_Homo sapiens_hsa005910.01737260

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