CDK5RAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.44471750
2nuclear pore complex assembly (GO:0051292)4.84330765
3mitotic sister chromatid cohesion (GO:0007064)4.75055960
4nuclear pore organization (GO:0006999)4.48674849
5sister chromatid segregation (GO:0000819)4.15659268
6protein localization to kinetochore (GO:0034501)4.03871986
7mitotic chromosome condensation (GO:0007076)4.02737087
8regulation of nucleobase-containing compound transport (GO:0032239)3.98738239
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.98682489
10mitotic sister chromatid segregation (GO:0000070)3.97228894
11protein localization to chromosome, centromeric region (GO:0071459)3.94373529
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.91402500
13DNA unwinding involved in DNA replication (GO:0006268)3.84764159
14regulation of histone H3-K27 methylation (GO:0061085)3.82467160
15microtubule depolymerization (GO:0007019)3.80679016
16regulation of histone H3-K9 methylation (GO:0051570)3.79268963
17DNA replication-dependent nucleosome organization (GO:0034723)3.79211513
18DNA replication-dependent nucleosome assembly (GO:0006335)3.79211513
19regulation of sister chromatid cohesion (GO:0007063)3.73639712
20kinetochore organization (GO:0051383)3.73585110
21pore complex assembly (GO:0046931)3.72030875
22chromosome condensation (GO:0030261)3.70755353
23DNA strand elongation involved in DNA replication (GO:0006271)3.64528972
24DNA synthesis involved in DNA repair (GO:0000731)3.53257815
25piRNA metabolic process (GO:0034587)3.53221679
26DNA strand elongation (GO:0022616)3.53152897
27DNA packaging (GO:0006323)3.49257470
28pre-miRNA processing (GO:0031054)3.47332280
29axonemal dynein complex assembly (GO:0070286)3.46895275
30chromatin assembly (GO:0031497)3.42578817
31meiotic chromosome segregation (GO:0045132)3.41511334
32heterochromatin organization (GO:0070828)3.38528087
33* regulation of centriole replication (GO:0046599)3.37257206
34sperm-egg recognition (GO:0035036)3.35292751
35synaptonemal complex assembly (GO:0007130)3.34679075
36mitotic nuclear envelope disassembly (GO:0007077)3.34143182
37regulation of RNA export from nucleus (GO:0046831)3.33823548
38acrosome assembly (GO:0001675)3.31322697
39translesion synthesis (GO:0019985)3.27868771
40glucocorticoid receptor signaling pathway (GO:0042921)3.27079684
41fusion of sperm to egg plasma membrane (GO:0007342)3.26662583
42paraxial mesoderm development (GO:0048339)3.26597326
43binding of sperm to zona pellucida (GO:0007339)3.25619534
44negative regulation of histone methylation (GO:0031061)3.23767737
45synaptonemal complex organization (GO:0070193)3.23138113
46regulation of translational fidelity (GO:0006450)3.22859782
47regulation of DNA endoreduplication (GO:0032875)3.21364403
48DNA duplex unwinding (GO:0032508)3.20307619
49DNA geometric change (GO:0032392)3.19507379
50protein export from nucleus (GO:0006611)3.18913913
51sperm motility (GO:0030317)3.16997701
52nucleosome disassembly (GO:0006337)3.15755198
53protein-DNA complex disassembly (GO:0032986)3.15755198
54male meiosis (GO:0007140)3.14512687
55nuclear envelope disassembly (GO:0051081)3.13460701
56membrane disassembly (GO:0030397)3.13460701
57regulation of chromosome segregation (GO:0051983)3.13256736
58peptidyl-lysine dimethylation (GO:0018027)3.11043027
59telomere maintenance via semi-conservative replication (GO:0032201)3.11028665
60gene silencing by RNA (GO:0031047)3.09292498
61DNA conformation change (GO:0071103)3.08168949
62spindle organization (GO:0007051)3.04660756
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04509734
64chromatin assembly or disassembly (GO:0006333)3.02154858
65histone H3-K36 demethylation (GO:0070544)3.01033446
66cell-cell recognition (GO:0009988)3.00506642
67protein localization to chromosome (GO:0034502)3.00194169
68positive regulation of mitotic sister chromatid separation (GO:1901970)2.97631524
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.97631524
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.97631524
71histone H3-K9 methylation (GO:0051567)2.96729463
72centrosome duplication (GO:0051298)2.94562771
73spermatid development (GO:0007286)2.94145431
74NLS-bearing protein import into nucleus (GO:0006607)2.92561034
75kinetochore assembly (GO:0051382)2.92441154
76positive regulation of chromosome segregation (GO:0051984)2.92132780
77histone H3-K9 demethylation (GO:0033169)2.89841435
78centriole replication (GO:0007099)2.89279525
79negative regulation of DNA repair (GO:0045738)2.88891006
80histone exchange (GO:0043486)2.87563331
81microtubule polymerization or depolymerization (GO:0031109)2.87308622
82epithelial cilium movement (GO:0003351)2.87301868
83mitotic recombination (GO:0006312)2.87202276
84* regulation of centrosome cycle (GO:0046605)2.86871027
85embryonic retina morphogenesis in camera-type eye (GO:0060059)2.85389763
86regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.84831710
87regulation of histone methylation (GO:0031060)2.84715529
88negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84202657
89motile cilium assembly (GO:0044458)2.84002450
90mitotic cytokinesis (GO:0000281)2.82356680
91mRNA stabilization (GO:0048255)2.82297589
92RNA stabilization (GO:0043489)2.82297589
93chromosome organization involved in meiosis (GO:0070192)2.81750395
94ATP-dependent chromatin remodeling (GO:0043044)2.81532301
95regulation of spindle organization (GO:0090224)2.80822680
96mitotic metaphase plate congression (GO:0007080)2.79309674
97regulation of mitotic spindle organization (GO:0060236)2.79163560
98gene silencing (GO:0016458)2.78892613
99nuclear envelope organization (GO:0006998)2.77674667
100* establishment of spindle localization (GO:0051293)2.77448316
101telomere maintenance via recombination (GO:0000722)2.76761933
102metaphase plate congression (GO:0051310)2.76550511
103corticosteroid receptor signaling pathway (GO:0031958)2.75238321
104DNA replication initiation (GO:0006270)2.73306606
105establishment of chromosome localization (GO:0051303)2.73211275
106double-strand break repair via nonhomologous end joining (GO:0006303)2.73180785
107non-recombinational repair (GO:0000726)2.73180785
108positive regulation of cell cycle checkpoint (GO:1901978)2.71999020
109regulation of mitotic metaphase/anaphase transition (GO:0030071)2.70437879
110interkinetic nuclear migration (GO:0022027)2.70428511
111negative regulation of chromosome segregation (GO:0051985)2.70120273
112V(D)J recombination (GO:0033151)2.69570760
113multicellular organism reproduction (GO:0032504)2.68979739
114spindle assembly (GO:0051225)2.68715195
115DNA topological change (GO:0006265)2.68561434
116DNA replication-independent nucleosome organization (GO:0034724)2.68518417
117DNA replication-independent nucleosome assembly (GO:0006336)2.68518417
118monoubiquitinated protein deubiquitination (GO:0035520)2.68438320
119* establishment of mitotic spindle localization (GO:0040001)2.67475259
120DNA ligation (GO:0006266)2.67144579
121regulation of DNA damage checkpoint (GO:2000001)2.66876416
122histone lysine demethylation (GO:0070076)2.66865669
123* chromosome segregation (GO:0007059)2.66368598
124* establishment of spindle orientation (GO:0051294)2.65094893
125positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.65093697
126sister chromatid cohesion (GO:0007062)2.64819108
127dosage compensation (GO:0007549)2.64327517
128regulation of NFAT protein import into nucleus (GO:0051532)2.64106879
129spliceosomal tri-snRNP complex assembly (GO:0000244)2.63731595
130regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.63381501
131meiotic nuclear division (GO:0007126)2.62913599
132negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.62845164
133negative regulation of sister chromatid segregation (GO:0033046)2.62845164
134negative regulation of mitotic sister chromatid separation (GO:2000816)2.62845164
135negative regulation of mitotic sister chromatid segregation (GO:0033048)2.62845164
136embryonic viscerocranium morphogenesis (GO:0048703)2.62238538
137histone H2B ubiquitination (GO:0033523)2.61892049
138histone H3-K9 modification (GO:0061647)2.61685179
139nucleus organization (GO:0006997)2.59306348
140positive regulation of DNA-dependent DNA replication (GO:2000105)2.57194413
141negative regulation of cell cycle G2/M phase transition (GO:1902750)2.54695777
142* regulation of centrosome duplication (GO:0010824)2.50739330
143regulation of histone H3-K4 methylation (GO:0051569)2.49792964

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.69255324
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.72854003
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.59502945
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.69227155
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.17526250
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.95493276
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.69496710
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.51254115
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.41308776
10AR_21909140_ChIP-Seq_LNCAP_Human2.36499494
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.25604707
12E2F7_22180533_ChIP-Seq_HELA_Human10.5223091
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97488725
14MYC_18555785_ChIP-Seq_MESCs_Mouse1.92533684
15* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88580304
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84104036
17SOX2_18555785_ChIP-Seq_MESCs_Mouse1.79092161
18* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.78942304
19CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.75363717
20* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73988013
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73764800
22MYC_22102868_ChIP-Seq_BL_Human1.71267346
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.70714133
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69287648
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68543393
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67248980
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54315576
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49988313
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49113802
30ZNF263_19887448_ChIP-Seq_K562_Human1.48786134
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47660855
32* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42604418
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41159743
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36167609
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36167609
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36167609
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35223891
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35142045
39* CIITA_25753668_ChIP-Seq_RAJI_Human1.33637943
40NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.32974591
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32314983
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31398713
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.30490387
44NCOR1_26117541_ChIP-Seq_K562_Human1.29930948
45PKCTHETA_26484144_Chip-Seq_BREAST_Human1.29594864
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28894174
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28366418
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26618168
49CLOCK_20551151_ChIP-Seq_293T_Human1.25760220
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23641485
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22905837
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22326384
53* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21811254
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21555765
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21200842
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.21046443
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17117332
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16525812
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.15547076
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13530015
61* NANOG_21062744_ChIP-ChIP_HESCs_Human1.13494995
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13350227
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.13287084
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12505229
65GATA1_19941826_ChIP-Seq_K562_Human1.10620368
66KDM2B_26808549_Chip-Seq_K562_Human1.10383866
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09817668
68* FOXA2_19822575_ChIP-Seq_HepG2_Human1.09796158
69XRN2_22483619_ChIP-Seq_HELA_Human1.09252702
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08731541
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.08636475
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08594700
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08123884
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08029261
75TCF7_22412390_ChIP-Seq_EML_Mouse1.06385202
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06231549
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05987073
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04168681
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03338198
80KDM5A_27292631_Chip-Seq_BREAST_Human1.03101455
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.02450121
82TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00244388
83CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97912296
84POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97727893
85VDR_21846776_ChIP-Seq_THP-1_Human0.97701190
86THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97630694
87* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97583118
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96857354
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95350968
90POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94969631
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94392205
92TP53_22127205_ChIP-Seq_IMR90_Human0.92757616
93EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91843278
94GATA1_22025678_ChIP-Seq_K562_Human0.91665416
95NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91459852
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91404452
97* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90942073
98SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90803803
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90509771
100RACK7_27058665_Chip-Seq_MCF-7_Human0.88622654
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88040796
102* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86849570
103LXR_22292898_ChIP-Seq_THP-1_Human0.85645543
104GATA2_19941826_ChIP-Seq_K562_Human0.85506746
105EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84941225
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84832436
107UBF1/2_26484160_Chip-Seq_HMECs_Human0.84716240
108* TTF2_22483619_ChIP-Seq_HELA_Human0.83706232
109* SMC4_20622854_ChIP-Seq_HELA_Human0.83676618
110ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83420853
111* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.83229299
112GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82890464
113TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.82847859
114POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81441869
115KDM2B_26808549_Chip-Seq_DND41_Human0.81234312
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79923176
117ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79458298
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78773446
119* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.78732145
120KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78546350
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78242528
122RUNX1_27514584_Chip-Seq_MCF-7_Human0.77601356
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77213225
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76900862
125* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.76885510
126SOX2_18692474_ChIP-Seq_MESCs_Mouse0.76276162
127ZFX_18555785_ChIP-Seq_MESCs_Mouse0.74721164
128ISL1_27105846_Chip-Seq_CPCs_Mouse0.74381215
129POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.74020154
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74018762
131NANOG_16153702_ChIP-ChIP_HESCs_Human0.73408797
132* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.72334792
133* SOX9_26525672_Chip-Seq_HEART_Mouse0.70503376
134CHD1_26751641_Chip-Seq_LNCaP_Human0.69935547
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69134702
136CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.68433182
137* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.68239225
138RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.67511574
139UTX_26944678_Chip-Seq_JUKART_Human0.67338188
140ELK4_26923725_Chip-Seq_MESODERM_Mouse0.67257892
141BRD4_25478319_ChIP-Seq_HGPS_Human0.66723742
142FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.66681281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.41238694
2MP0010094_abnormal_chromosome_stability3.25568738
3MP0005410_abnormal_fertilization3.13746810
4* MP0003111_abnormal_nucleus_morphology2.84481040
5MP0008057_abnormal_DNA_replication2.52759258
6* MP0003077_abnormal_cell_cycle2.46338685
7MP0008877_abnormal_DNA_methylation2.42745842
8MP0002653_abnormal_ependyma_morphology2.17678375
9MP0010030_abnormal_orbit_morphology2.13213047
10MP0003121_genomic_imprinting2.03930706
11MP0002009_preneoplasia1.98038198
12MP0005623_abnormal_meninges_morphology1.95999682
13MP0001293_anophthalmia1.95739445
14MP0010307_abnormal_tumor_latency1.92601442
15MP0004957_abnormal_blastocyst_morpholog1.92136898
16MP0005076_abnormal_cell_differentiation1.90356196
17MP0003693_abnormal_embryo_hatching1.89967392
18MP0003656_abnormal_erythrocyte_physiolo1.86125209
19MP0008058_abnormal_DNA_repair1.81839308
20MP0002877_abnormal_melanocyte_morpholog1.80924665
21* MP0001929_abnormal_gametogenesis1.80440584
22MP0000733_abnormal_muscle_development1.77993275
23MP0003123_paternal_imprinting1.74484904
24MP0005451_abnormal_body_composition1.73651409
25MP0003937_abnormal_limbs/digits/tail_de1.72884014
26* MP0003698_abnormal_male_reproductive1.72754706
27MP0005409_darkened_coat_color1.71169506
28MP0004185_abnormal_adipocyte_glucose1.69046301
29MP0001730_embryonic_growth_arrest1.68765342
30MP0002084_abnormal_developmental_patter1.67621456
31MP0008932_abnormal_embryonic_tissue1.67085321
32MP0004197_abnormal_fetal_growth/weight/1.63681828
33MP0002210_abnormal_sex_determination1.62032163
34MP0000537_abnormal_urethra_morphology1.61584857
35MP0000350_abnormal_cell_proliferation1.60186564
36MP0002085_abnormal_embryonic_tissue1.57236601
37MP0010352_gastrointestinal_tract_polyps1.55719844
38MP0002938_white_spotting1.51150066
39MP0003566_abnormal_cell_adhesion1.50292109
40MP0001849_ear_inflammation1.49887654
41MP0005171_absent_coat_pigmentation1.49695121
42MP0009697_abnormal_copulation1.49423840
43MP0005083_abnormal_biliary_tract1.49008335
44MP0003705_abnormal_hypodermis_morpholog1.47449664
45* MP0008007_abnormal_cellular_replicative1.46614436
46MP0003787_abnormal_imprinting1.46364954
47MP0001915_intracranial_hemorrhage1.44470689
48MP0001672_abnormal_embryogenesis/_devel1.43705933
49MP0005380_embryogenesis_phenotype1.43705933
50MP0003942_abnormal_urinary_system1.41300234
51MP0001697_abnormal_embryo_size1.39597805
52MP0000428_abnormal_craniofacial_morphol1.39066567
53MP0000049_abnormal_middle_ear1.38890885
54MP0009278_abnormal_bone_marrow1.37842865
55MP0001145_abnormal_male_reproductive1.37310522
56MP0009053_abnormal_anal_canal1.35018178
57MP0002697_abnormal_eye_size1.34789217
58MP0003115_abnormal_respiratory_system1.33945999
59MP0002396_abnormal_hematopoietic_system1.33058095
60MP0003385_abnormal_body_wall1.32886620
61MP0000747_muscle_weakness1.31272708
62MP0010630_abnormal_cardiac_muscle1.30932691
63MP0003935_abnormal_craniofacial_develop1.30028354
64MP0004087_abnormal_muscle_fiber1.29056381
65MP0005408_hypopigmentation1.27724076
66MP0000432_abnormal_head_morphology1.27236285
67MP0003890_abnormal_embryonic-extraembry1.26370490
68MP0009250_abnormal_appendicular_skeleto1.25592962
69MP0003984_embryonic_growth_retardation1.25188446
70MP0002282_abnormal_trachea_morphology1.24685075
71MP0003941_abnormal_skin_development1.23968931
72MP0002088_abnormal_embryonic_growth/wei1.22964249
73MP0000566_synostosis1.22599897
74MP0004808_abnormal_hematopoietic_stem1.21625886
75MP0000534_abnormal_ureter_morphology1.21477677
76MP0001661_extended_life_span1.20771761
77MP0003755_abnormal_palate_morphology1.20767787
78* MP0002092_abnormal_eye_morphology1.19788786
79MP0004134_abnormal_chest_morphology1.18911498
80MP0002080_prenatal_lethality1.18102275
81MP0002269_muscular_atrophy1.17678496
82MP0002086_abnormal_extraembryonic_tissu1.17141282
83* MP0003861_abnormal_nervous_system1.16332394
84MP0000653_abnormal_sex_gland1.15976527
85MP0000759_abnormal_skeletal_muscle1.15013763
86MP0004133_heterotaxia1.13045181
87MP0002116_abnormal_craniofacial_bone1.12832878
88MP0002932_abnormal_joint_morphology1.11996705
89MP0005257_abnormal_intraocular_pressure1.08470214
90MP0009703_decreased_birth_body1.07788324
91MP0001299_abnormal_eye_distance/1.07316326
92MP0003878_abnormal_ear_physiology1.06258536
93MP0005377_hearing/vestibular/ear_phenot1.06258536
94MP0000751_myopathy1.05939859
95* MP0002161_abnormal_fertility/fecundity1.04373817
96MP0002233_abnormal_nose_morphology1.03355980
97MP0002249_abnormal_larynx_morphology1.02914087
98MP0003283_abnormal_digestive_organ1.02895245
99MP0005666_abnormal_adipose_tissue1.00532851
100MP0005503_abnormal_tendon_morphology1.00388129
101MP0005621_abnormal_cell_physiology1.00106818
102MP0003119_abnormal_digestive_system0.96672111
103MP0003122_maternal_imprinting0.95519793
104MP0004233_abnormal_muscle_weight0.95183823
105MP0002111_abnormal_tail_morphology0.93902839
106MP0000371_diluted_coat_color0.93180810
107MP0005174_abnormal_tail_pigmentation0.91394701
108MP0002109_abnormal_limb_morphology0.90619947
109MP0002925_abnormal_cardiovascular_devel0.90030695
110MP0003938_abnormal_ear_development0.89737049
111* MP0002114_abnormal_axial_skeleton0.89681549
112* MP0005391_vision/eye_phenotype0.89664948
113MP0002089_abnormal_postnatal_growth/wei0.89482750
114MP0005187_abnormal_penis_morphology0.89123286
115MP0000313_abnormal_cell_death0.88310471
116MP0001346_abnormal_lacrimal_gland0.88279400
117MP0000749_muscle_degeneration0.88238245
118MP0005384_cellular_phenotype0.88125959
119MP0004272_abnormal_basement_membrane0.87640772
120MP0002095_abnormal_skin_pigmentation0.87446757
121MP0006138_congestive_heart_failure0.86558702
122MP0009672_abnormal_birth_weight0.86291129
123MP0003646_muscle_fatigue0.85905005
124MP0004264_abnormal_extraembryonic_tissu0.85649757
125MP0003091_abnormal_cell_migration0.85476299
126MP0002075_abnormal_coat/hair_pigmentati0.84833213
127MP0003786_premature_aging0.82996848
128MP0001286_abnormal_eye_development0.82883127
129MP0000015_abnormal_ear_pigmentation0.82706136
130MP0002177_abnormal_outer_ear0.82366032
131MP0003943_abnormal_hepatobiliary_system0.81421798
132MP0005397_hematopoietic_system_phenotyp0.81030381
133MP0001545_abnormal_hematopoietic_system0.81030381
134MP0000003_abnormal_adipose_tissue0.80836082
135MP0002108_abnormal_muscle_morphology0.80829765
136MP0001348_abnormal_lacrimal_gland0.80587261
137MP0005023_abnormal_wound_healing0.80157873
138MP0000266_abnormal_heart_morphology0.78026574
139MP0002081_perinatal_lethality0.76649207
140MP0008260_abnormal_autophagy0.75007424
141MP0003453_abnormal_keratinocyte_physiol0.74907893
142MP0003221_abnormal_cardiomyocyte_apopto0.72202234

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.06870525
2Absent/shortened dynein arms (HP:0200106)3.44536665
3Dynein arm defect of respiratory motile cilia (HP:0012255)3.44536665
4Short 4th metacarpal (HP:0010044)3.34614731
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.34614731
6Increased nuchal translucency (HP:0010880)2.96595619
7Volvulus (HP:0002580)2.75839438
8Vertebral arch anomaly (HP:0008438)2.71816735
9Abnormal respiratory motile cilium physiology (HP:0012261)2.70099407
10Abnormality of the calcaneus (HP:0008364)2.62368300
11Abnormal respiratory motile cilium morphology (HP:0005938)2.59535736
12Abnormal respiratory epithelium morphology (HP:0012253)2.59535736
13Flat acetabular roof (HP:0003180)2.57817945
14Renal duplication (HP:0000075)2.51214898
15Deep philtrum (HP:0002002)2.48670876
16Selective tooth agenesis (HP:0001592)2.47699249
17Cortical dysplasia (HP:0002539)2.47172826
18Abnormality of the 4th metacarpal (HP:0010012)2.45568082
19Broad palm (HP:0001169)2.41066455
20Hyperacusis (HP:0010780)2.34834510
21Ectopic kidney (HP:0000086)2.33792788
22Renovascular hypertension (HP:0100817)2.33435357
23Aplasia/Hypoplasia of the sternum (HP:0006714)2.29647787
24Trigonocephaly (HP:0000243)2.27430716
25Metaphyseal cupping (HP:0003021)2.25124557
26Supernumerary spleens (HP:0009799)2.22991621
27Chromsome breakage (HP:0040012)2.22557937
28Rhinitis (HP:0012384)2.22517620
29Shallow orbits (HP:0000586)2.22309720
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21015211
31Overlapping toe (HP:0001845)2.18499818
32Reticulocytosis (HP:0001923)2.16989881
33Absent frontal sinuses (HP:0002688)2.14263413
34Supernumerary ribs (HP:0005815)2.11020192
35Sandal gap (HP:0001852)2.10819581
36Astrocytoma (HP:0009592)2.10247242
37Abnormality of the astrocytes (HP:0100707)2.10247242
38Bell-shaped thorax (HP:0001591)2.09214403
39Deep venous thrombosis (HP:0002625)2.07576677
40Heterotopia (HP:0002282)2.06030568
41Proximal placement of thumb (HP:0009623)2.05613392
42Impulsivity (HP:0100710)2.05308136
43Macroorchidism (HP:0000053)2.02853506
44Nephronophthisis (HP:0000090)2.02385869
45Neoplasm of the oral cavity (HP:0100649)2.01952108
46Abnormality of the fingertips (HP:0001211)2.01941738
47Deviation of the thumb (HP:0009603)2.01357643
48Overriding aorta (HP:0002623)2.00627175
49Abnormality of reticulocytes (HP:0004312)2.00137567
50Poikilocytosis (HP:0004447)1.99352941
51Supernumerary bones of the axial skeleton (HP:0009144)1.97221205
52Abnormal ciliary motility (HP:0012262)1.96857750
53Fibular hypoplasia (HP:0003038)1.96291910
54Medulloblastoma (HP:0002885)1.95731409
55High anterior hairline (HP:0009890)1.95438833
56Hypopigmentation of the fundus (HP:0007894)1.95404775
57Ependymoma (HP:0002888)1.94296122
58Calcaneovalgus deformity (HP:0001848)1.94196992
59Centrally nucleated skeletal muscle fibers (HP:0003687)1.94055505
60Long eyelashes (HP:0000527)1.92810491
61Bowel incontinence (HP:0002607)1.92264884
62Elfin facies (HP:0004428)1.92194536
63Flared metaphyses (HP:0003015)1.90993529
64Missing ribs (HP:0000921)1.90946009
65Midline defect of the nose (HP:0004122)1.90720940
66Flat cornea (HP:0007720)1.90417921
67Ankyloglossia (HP:0010296)1.90394808
68Skull defect (HP:0001362)1.90370300
69Truncal obesity (HP:0001956)1.90073552
70Abnormality of the lower motor neuron (HP:0002366)1.89882356
71Pseudobulbar signs (HP:0002200)1.89062224
72Pointed chin (HP:0000307)1.89033202
73Atresia of the external auditory canal (HP:0000413)1.88123109
74Increased connective tissue (HP:0009025)1.86018184
75High pitched voice (HP:0001620)1.84202325
76Broad phalanges of the hand (HP:0009768)1.84014202
77Nephroblastoma (Wilms tumor) (HP:0002667)1.84006114
78Broad thumb (HP:0011304)1.83539455
79Attention deficit hyperactivity disorder (HP:0007018)1.82700710
80Dysmetric saccades (HP:0000641)1.82357117
81Short ribs (HP:0000773)1.82175415
82Acanthocytosis (HP:0001927)1.82108531
83Patellar dislocation (HP:0002999)1.80943852
84Cafe-au-lait spot (HP:0000957)1.80742202
85Abnormal large intestine physiology (HP:0012700)1.79576975
86Broad distal phalanx of finger (HP:0009836)1.78623477
87Abnormality of the thoracic spine (HP:0100711)1.78448480
88Exercise-induced myalgia (HP:0003738)1.78241775
89Deep palmar crease (HP:0006191)1.77841204
90Abnormality of the carotid arteries (HP:0005344)1.77838906
91Abnormality of chromosome segregation (HP:0002916)1.76813261
92Abnormal number of incisors (HP:0011064)1.76659668
93Facial cleft (HP:0002006)1.76494683
94Abnormality of abdominal situs (HP:0011620)1.75523840
95Abdominal situs inversus (HP:0003363)1.75523840
96Asymmetry of the thorax (HP:0001555)1.75335994
97Glioma (HP:0009733)1.74989470
98Meckel diverticulum (HP:0002245)1.73498113
99Limited elbow extension (HP:0001377)1.72863037
100Disproportionate tall stature (HP:0001519)1.72619282
101Esophageal atresia (HP:0002032)1.72259092
102Thin ribs (HP:0000883)1.71532538
103Abnormal foot bone ossification (HP:0010675)1.71343778
104Leiomyosarcoma (HP:0100243)1.71040124
105Uterine leiomyosarcoma (HP:0002891)1.71040124
106Embryonal renal neoplasm (HP:0011794)1.69816633
107Aplasia/Hypoplasia of the uvula (HP:0010293)1.69687318
108Abnormality of the acetabulum (HP:0003170)1.69580753
109Insidious onset (HP:0003587)1.69564493
110Termporal pattern (HP:0011008)1.69564493
111Obsessive-compulsive behavior (HP:0000722)1.67730688
112Chronic bronchitis (HP:0004469)1.67593056
113Abnormality of the renal collecting system (HP:0004742)1.67147351
114Abnormality of the left ventricular outflow tract (HP:0011103)1.67010901
115Subaortic stenosis (HP:0001682)1.67010901
116Broad finger (HP:0001500)1.66901005
117Diastasis recti (HP:0001540)1.66315362
118Abnormality of the ileum (HP:0001549)1.65147007
119Reticulocytopenia (HP:0001896)1.64560459
120Megalocornea (HP:0000485)1.64541779
121Papillary thyroid carcinoma (HP:0002895)1.64459251
122Broad phalanx (HP:0006009)1.64250736
123Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.63732728
124Abnormality of chromosome stability (HP:0003220)1.63671855
125Abnormality of the diencephalon (HP:0010662)1.63535927
126Protrusio acetabuli (HP:0003179)1.63271539
127Aplasia/Hypoplasia of the earlobes (HP:0009906)1.63001962
128Short phalanx of the thumb (HP:0009660)1.62902737
129Skin tags (HP:0010609)1.61856187
13011 pairs of ribs (HP:0000878)1.61761894
131Short 1st metacarpal (HP:0010034)1.61469005
132Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.61469005
133Abnormality of the distal phalanx of the thumb (HP:0009617)1.61305076
134Small epiphyses (HP:0010585)1.61122271
135Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.61059879
136Ulnar bowing (HP:0003031)1.60852227
137Long clavicles (HP:0000890)1.60549625
138Broad face (HP:0000283)1.59871232
139Deformed tarsal bones (HP:0008119)1.59816670
140Neoplasm of striated muscle (HP:0009728)1.59595665
141Hepatoblastoma (HP:0002884)1.59541667
142Abnormality of the epiphyses of the hand (HP:0005924)1.58624035
143Narrow palate (HP:0000189)1.58611294
144Chin dimple (HP:0010751)1.58457847
145Absent epiphyses (HP:0010577)1.58087505
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.58087505
147Abnormal lung lobation (HP:0002101)1.57709316
148Abnormality of the phalanges of the hallux (HP:0010057)1.56798800
149Dislocated radial head (HP:0003083)1.56635027
150Broad long bones (HP:0005622)1.56321419
151Bowel diverticulosis (HP:0005222)1.56146002
152Prominent nose (HP:0000448)1.54772085
153Abnormality of the renal medulla (HP:0100957)1.54603994
154Abnormality of the labia minora (HP:0012880)1.54265295
155Duplication of thumb phalanx (HP:0009942)1.54156297
156* Sloping forehead (HP:0000340)1.53433630
157Narrow face (HP:0000275)1.53269401
158Abnormality of the radial head (HP:0003995)1.53193072
159Insomnia (HP:0100785)1.53150984
160Abnormality of DNA repair (HP:0003254)1.52961190
161Rhizomelia (HP:0008905)1.52556960
162Nasal polyposis (HP:0100582)1.52161949
163Duodenal stenosis (HP:0100867)1.52037833
164Small intestinal stenosis (HP:0012848)1.52037833
165Colon cancer (HP:0003003)1.51887980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.42556252
2CDK124.09388551
3NEK23.38359784
4ICK2.63858922
5EEF2K2.62788081
6MAP3K102.39271138
7PNCK2.30538069
8BUB12.26143805
9SMG12.25980297
10TTK2.10345644
11BRD42.06053823
12PDK42.05562715
13PDK32.05562715
14WEE11.96657494
15EIF2AK11.91072603
16FGFR41.85152987
17MKNK11.80250870
18ATR1.79198751
19PRKD31.74322969
20TESK11.70519037
21LATS11.66164873
22PASK1.56306375
23CHEK11.56179429
24CHEK21.53114447
25TLK11.48823468
26PLK11.46684537
27CAMK1G1.42375387
28PRPF4B1.37448241
29AURKB1.34676133
30MTOR1.32698245
31SRPK11.31327849
32MKNK21.31004171
33CDK71.25357933
34TYRO31.25038369
35STK31.24427349
36ATM1.23782763
37TTN1.23016901
38PKN21.16310521
39BRSK11.16079686
40CDK41.15045460
41PAK41.14832785
42CDK61.14610336
43RPS6KB21.13818571
44FGFR31.13737010
45DYRK31.13501539
46PTK61.12154466
47TESK21.11640919
48PDGFRA1.11069583
49DDR21.10596230
50STK101.09804300
51STK41.07257076
52KSR21.05555301
53MAP3K81.02709928
54BMX1.00818745
55PLK31.00521632
56CDK21.00207679
57NEK90.99304903
58PLK40.97504602
59DYRK1B0.96035773
60RPS6KA40.95424591
61PAK20.89932399
62CDK10.89826595
63FGFR10.89206758
64TRIB30.88044230
65SCYL20.86110675
66PDK20.84311248
67PDGFRB0.83875081
68MST1R0.82952671
69CAMK1D0.81363008
70FGFR20.79593271
71BRAF0.79188011
72MAPK110.79089535
73RET0.78141439
74MAP3K70.77097877
75ALK0.77000159
76CSNK1D0.75244800
77CDK80.74716339
78OBSCN0.72199942
79PRKDC0.70106133
80MARK20.69973230
81ERBB20.69530411
82WNK10.68951095
83LATS20.68896451
84CDC42BPA0.68159517
85SGK30.67890630
86MAP2K30.67144343
87SIK10.66497585
88MET0.64648650
89TRPM70.63725998
90VRK10.62147632
91RPS6KA50.61975255
92MAP3K60.61842519
93CLK10.60133621
94KSR10.59521393
95CCNB10.58627314
96PBK0.57874564
97AURKA0.56342514
98MARK30.55525782
99MAPK140.55157728
100CSNK1E0.54264565
101SIK20.53892836
102NEK10.53436692
103CDK90.53071407
104RAF10.52658179
105GSK3B0.52370146
106MELK0.51552916
107ZAK0.50899761
108TSSK60.50580797
109UHMK10.50491744
110BRSK20.50323412
111BCR0.49988486
112CSNK1A1L0.49802997
113AKT30.49298016
114PIM10.47356964
115MAP3K20.46876504
116AKT10.46673800
117PRKAA20.46630031
118MAPK10.45343815
119STK380.45211719
120CDK30.44686419
121ERBB30.43935707
122AKT20.43617658
123PAK10.42318242
124DMPK0.42114991
125MAPK100.41476817
126PTK2B0.41298530
127RIPK10.41139997
128RPS6KA10.40908713
129SGK10.39224158
130MAPK80.38864711
131PRKAA10.38694157
132PTK20.36032365
133SGK20.35928785

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.39061723
2Mismatch repair_Homo sapiens_hsa034302.97636557
3Cell cycle_Homo sapiens_hsa041102.81980262
4Fanconi anemia pathway_Homo sapiens_hsa034602.66290897
5RNA transport_Homo sapiens_hsa030132.52898312
6Spliceosome_Homo sapiens_hsa030402.52165102
7mRNA surveillance pathway_Homo sapiens_hsa030152.35816248
8Base excision repair_Homo sapiens_hsa034102.20063583
9Homologous recombination_Homo sapiens_hsa034402.09910017
10One carbon pool by folate_Homo sapiens_hsa006702.07368021
11Nucleotide excision repair_Homo sapiens_hsa034202.05293787
12Basal cell carcinoma_Homo sapiens_hsa052172.00244185
13Non-homologous end-joining_Homo sapiens_hsa034501.92726023
14Systemic lupus erythematosus_Homo sapiens_hsa053221.90398195
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78111184
16MicroRNAs in cancer_Homo sapiens_hsa052061.74259716
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.70549524
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67377152
19Basal transcription factors_Homo sapiens_hsa030221.61481469
20Hedgehog signaling pathway_Homo sapiens_hsa043401.60572353
21Oocyte meiosis_Homo sapiens_hsa041141.53944771
22Small cell lung cancer_Homo sapiens_hsa052221.46126776
23Viral carcinogenesis_Homo sapiens_hsa052031.45328236
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.44538956
25RNA degradation_Homo sapiens_hsa030181.43187236
26Hippo signaling pathway_Homo sapiens_hsa043901.43109227
27Lysine degradation_Homo sapiens_hsa003101.43063077
28Notch signaling pathway_Homo sapiens_hsa043301.39264102
29p53 signaling pathway_Homo sapiens_hsa041151.35215769
30HTLV-I infection_Homo sapiens_hsa051661.33798839
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.32620039
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31870818
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31434779
34Biosynthesis of amino acids_Homo sapiens_hsa012301.25304022
35Adherens junction_Homo sapiens_hsa045201.20987115
36Chronic myeloid leukemia_Homo sapiens_hsa052201.18126735
37Dorso-ventral axis formation_Homo sapiens_hsa043201.17872186
38Alcoholism_Homo sapiens_hsa050341.16239216
39Wnt signaling pathway_Homo sapiens_hsa043101.10847196
40Colorectal cancer_Homo sapiens_hsa052101.09593656
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08739366
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07915188
43Proteoglycans in cancer_Homo sapiens_hsa052051.06491217
44ErbB signaling pathway_Homo sapiens_hsa040121.05593001
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03602571
46Insulin signaling pathway_Homo sapiens_hsa049101.03469402
47Choline metabolism in cancer_Homo sapiens_hsa052311.00986578
48ECM-receptor interaction_Homo sapiens_hsa045120.95763787
49Prostate cancer_Homo sapiens_hsa052150.95295790
50Pathways in cancer_Homo sapiens_hsa052000.92107153
51Antigen processing and presentation_Homo sapiens_hsa046120.90980791
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.90733296
53Epstein-Barr virus infection_Homo sapiens_hsa051690.89462324
54Viral myocarditis_Homo sapiens_hsa054160.88836065
55Focal adhesion_Homo sapiens_hsa045100.88106229
56TGF-beta signaling pathway_Homo sapiens_hsa043500.86711519
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83522703
58Pentose phosphate pathway_Homo sapiens_hsa000300.82628503
59Carbon metabolism_Homo sapiens_hsa012000.82368819
60Tight junction_Homo sapiens_hsa045300.82058772
61Non-small cell lung cancer_Homo sapiens_hsa052230.81939786
62Endometrial cancer_Homo sapiens_hsa052130.79559254
63mTOR signaling pathway_Homo sapiens_hsa041500.79228771
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75784894
65Pyrimidine metabolism_Homo sapiens_hsa002400.75227859
66Herpes simplex infection_Homo sapiens_hsa051680.73486759
67Melanoma_Homo sapiens_hsa052180.72094779
68Axon guidance_Homo sapiens_hsa043600.71374716
69Arginine biosynthesis_Homo sapiens_hsa002200.70832478
70Complement and coagulation cascades_Homo sapiens_hsa046100.69858926
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68667879
72Prolactin signaling pathway_Homo sapiens_hsa049170.67942263
73Pancreatic cancer_Homo sapiens_hsa052120.67937039
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66471831
75Glioma_Homo sapiens_hsa052140.66109806
76Platelet activation_Homo sapiens_hsa046110.65394037
77Renal cell carcinoma_Homo sapiens_hsa052110.65252304
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64866456
79Dilated cardiomyopathy_Homo sapiens_hsa054140.64004622
80Fatty acid metabolism_Homo sapiens_hsa012120.63953467
81Melanogenesis_Homo sapiens_hsa049160.63562863
82Insulin resistance_Homo sapiens_hsa049310.62917105
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61929694
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.61669587
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61070735
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60802681
87Estrogen signaling pathway_Homo sapiens_hsa049150.59404236
88Prion diseases_Homo sapiens_hsa050200.59279645
89Glucagon signaling pathway_Homo sapiens_hsa049220.58723950
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.56983556
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56309173
92Bladder cancer_Homo sapiens_hsa052190.55249630
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55090469
94Hepatitis B_Homo sapiens_hsa051610.54766245
95Selenocompound metabolism_Homo sapiens_hsa004500.54048211
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53850949
97Fatty acid biosynthesis_Homo sapiens_hsa000610.52946231
98Rap1 signaling pathway_Homo sapiens_hsa040150.49881150
99B cell receptor signaling pathway_Homo sapiens_hsa046620.49344947
100Type II diabetes mellitus_Homo sapiens_hsa049300.49265625
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.48987314
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48436755
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48200032
104T cell receptor signaling pathway_Homo sapiens_hsa046600.47031043
105Thyroid cancer_Homo sapiens_hsa052160.46623344
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45540822
107Gap junction_Homo sapiens_hsa045400.45455421
108RNA polymerase_Homo sapiens_hsa030200.45081005
109VEGF signaling pathway_Homo sapiens_hsa043700.44757853
110Apoptosis_Homo sapiens_hsa042100.44464446
111Toxoplasmosis_Homo sapiens_hsa051450.44032430
112FoxO signaling pathway_Homo sapiens_hsa040680.43678296
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42504092
114AMPK signaling pathway_Homo sapiens_hsa041520.41969398
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41900851
116Inositol phosphate metabolism_Homo sapiens_hsa005620.41666110
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41332651
118HIF-1 signaling pathway_Homo sapiens_hsa040660.41277833
119MAPK signaling pathway_Homo sapiens_hsa040100.41142197
120Purine metabolism_Homo sapiens_hsa002300.40524319
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39818540
122Vitamin B6 metabolism_Homo sapiens_hsa007500.36346323
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.35621368
124Measles_Homo sapiens_hsa051620.35575910
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34026566
126Acute myeloid leukemia_Homo sapiens_hsa052210.33158548

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