CDK5RAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)9.08436655
2doxorubicin metabolic process (GO:0044598)9.08436655
3daunorubicin metabolic process (GO:0044597)9.08436655
4aminoglycoside antibiotic metabolic process (GO:0030647)5.95213215
5mannose metabolic process (GO:0006013)5.84242451
6positive regulation of gamma-delta T cell activation (GO:0046645)5.37177183
7protein localization to kinetochore (GO:0034501)5.29710218
8negative regulation of erythrocyte differentiation (GO:0045647)5.25250419
9maintenance of protein location in nucleus (GO:0051457)5.16466250
10regulation of mammary gland epithelial cell proliferation (GO:0033599)5.07714936
11antigen processing and presentation of endogenous antigen (GO:0019883)5.05551618
12coenzyme catabolic process (GO:0009109)4.95076016
13regulation of telomere maintenance via telomerase (GO:0032210)4.85619220
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.84238615
15somite rostral/caudal axis specification (GO:0032525)4.84222628
16negative regulation of epidermis development (GO:0045683)4.78627731
17regulation of nuclear cell cycle DNA replication (GO:0033262)4.75958455
18negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.73522894
19rRNA transcription (GO:0009303)4.71274087
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.62805175
21cellular modified amino acid catabolic process (GO:0042219)4.53001497
22negative regulation of telomerase activity (GO:0051974)4.51947468
23hormone catabolic process (GO:0042447)4.50774079
24negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.48833155
25regulation of response to osmotic stress (GO:0047484)4.45127611
26muscle organ morphogenesis (GO:0048644)4.42916462
27negative regulation of cell cycle G2/M phase transition (GO:1902750)4.42323652
28positive thymic T cell selection (GO:0045059)4.40260577
29rRNA methylation (GO:0031167)4.29066278
30sulfur amino acid catabolic process (GO:0000098)4.25173925
31DNA replication-dependent nucleosome organization (GO:0034723)4.12282879
32DNA replication-dependent nucleosome assembly (GO:0006335)4.12282879
33regulation of translation in response to stress (GO:0043555)4.09636673
34histone H4-K5 acetylation (GO:0043981)4.09489755
35histone H4-K8 acetylation (GO:0043982)4.09489755
36histone H4-K12 acetylation (GO:0043983)4.09111291
37rRNA modification (GO:0000154)4.08807996
38GDP-mannose metabolic process (GO:0019673)4.04788127
39negative regulation of cell killing (GO:0031342)4.00230101
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.00230101
41positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.99131912
42protein localization to chromosome, centromeric region (GO:0071459)3.98078671
43mitotic sister chromatid segregation (GO:0000070)3.97078152
44thymic T cell selection (GO:0045061)3.92525005
45detection of bacterium (GO:0016045)3.92403470
46regulation of gamma-delta T cell activation (GO:0046643)3.90608006
47response to muramyl dipeptide (GO:0032495)3.89422009
48negative thymic T cell selection (GO:0045060)3.88921334
49histone H4 deacetylation (GO:0070933)3.85423914
50quinone metabolic process (GO:1901661)3.85000494
51negative regulation of epidermal cell differentiation (GO:0045605)3.82931411
52heterochromatin organization (GO:0070828)3.82438427
53pteridine-containing compound biosynthetic process (GO:0042559)3.81103018
54regulation of gamma-delta T cell differentiation (GO:0045586)3.75346193
55positive regulation of B cell differentiation (GO:0045579)3.74690595
56nucleoside transmembrane transport (GO:1901642)3.73533249
57DNA replication checkpoint (GO:0000076)3.71585791
58primitive streak formation (GO:0090009)3.67462472
59regulation of MHC class I biosynthetic process (GO:0045343)3.66766455
60detection of other organism (GO:0098543)3.66471611
61immunoglobulin mediated immune response (GO:0016064)3.66012413
62regulation of apoptotic process involved in morphogenesis (GO:1902337)3.65003747
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.64962787
64B cell receptor signaling pathway (GO:0050853)3.63852277
65maintenance of protein localization in organelle (GO:0072595)3.61910025
66response to dietary excess (GO:0002021)3.61697217
67poly(A)+ mRNA export from nucleus (GO:0016973)3.61372100
68cullin deneddylation (GO:0010388)3.61037545
69cytidine metabolic process (GO:0046087)3.58088810
70cytidine catabolic process (GO:0006216)3.58088810
71cytidine deamination (GO:0009972)3.58088810
72primary alcohol catabolic process (GO:0034310)3.56517973
73epoxygenase P450 pathway (GO:0019373)3.56236958
74regulation of cilium movement (GO:0003352)3.55913462
75negative regulation of telomere maintenance (GO:0032205)3.55613558
76regulation of ARF GTPase activity (GO:0032312)3.54821480
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.54498065
78positive regulation of DNA-dependent DNA replication (GO:2000105)3.53821184
79Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52125839
80negative T cell selection (GO:0043383)3.51982617
81T cell selection (GO:0045058)3.50797798
82formation of translation preinitiation complex (GO:0001731)3.47732340
83phenol-containing compound catabolic process (GO:0019336)3.45754952
84histone H3 deacetylation (GO:0070932)3.44980538
85maternal placenta development (GO:0001893)3.42953234
86notochord development (GO:0030903)3.41667492
87regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.38488425
88positive regulation of granulocyte differentiation (GO:0030854)3.36793832
89chromatin assembly (GO:0031497)3.35518105
90protein deneddylation (GO:0000338)3.33195749
91positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.27702411
92sister chromatid segregation (GO:0000819)3.25849577
93ribosome biogenesis (GO:0042254)3.22940768
94positive T cell selection (GO:0043368)3.22147772
95regulation of B cell receptor signaling pathway (GO:0050855)3.19481432
96interferon-gamma production (GO:0032609)3.18518937
97mucosal-associated lymphoid tissue development (GO:0048537)3.16713298
98Peyers patch development (GO:0048541)3.16713298
99transcription from mitochondrial promoter (GO:0006390)3.15373991
100cofactor transport (GO:0051181)3.14225393
101modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.13669750
102positive regulation by organism of defense response of other organism involved in symbiotic interact3.13669750
103modulation by symbiont of host immune response (GO:0052553)3.13669750
104positive regulation by symbiont of host defense response (GO:0052509)3.13669750
105modulation by symbiont of host defense response (GO:0052031)3.13669750
106modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.13669750
107ribosomal small subunit biogenesis (GO:0042274)3.11731647
108folic acid-containing compound biosynthetic process (GO:0009396)3.09914775
109biotin metabolic process (GO:0006768)3.09573299
110heme transport (GO:0015886)3.07741618
111intestinal epithelial cell development (GO:0060576)3.06445462
112response to peptidoglycan (GO:0032494)3.06300878
113branching involved in mammary gland duct morphogenesis (GO:0060444)3.05440312
114regulation of B cell differentiation (GO:0045577)3.05218838
115cofactor catabolic process (GO:0051187)3.04240158
116valine metabolic process (GO:0006573)3.03043932
117histone H3-K9 demethylation (GO:0033169)3.02405140
118regulation of antigen processing and presentation (GO:0002577)3.01310627
119pseudouridine synthesis (GO:0001522)3.01228963
120regulation of granulocyte differentiation (GO:0030852)3.00026220
121nuclear pore complex assembly (GO:0051292)2.99358086
122positive regulation of antigen processing and presentation (GO:0002579)2.99245972
123L-ascorbic acid metabolic process (GO:0019852)2.95734332
124positive regulation of protein deacetylation (GO:0090312)2.95413827
125response to type I interferon (GO:0034340)2.92880514
126DNA damage response, detection of DNA damage (GO:0042769)2.92064621
127regulation of posttranscriptional gene silencing (GO:0060147)2.91528790
128regulation of gene silencing by miRNA (GO:0060964)2.91528790
129regulation of gene silencing by RNA (GO:0060966)2.91528790
130germinal center formation (GO:0002467)2.90456529
131type I interferon signaling pathway (GO:0060337)2.89885640
132cellular response to type I interferon (GO:0071357)2.89885640
133regulation of telomerase activity (GO:0051972)2.88258418
134erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.87245043
135L-phenylalanine metabolic process (GO:0006558)2.87245043
136antigen processing and presentation via MHC class Ib (GO:0002475)2.86667003
137DNA unwinding involved in DNA replication (GO:0006268)2.86564161
138DNA duplex unwinding (GO:0032508)2.86410042
139regulation of type I interferon-mediated signaling pathway (GO:0060338)2.86082545
140regulation of interferon-beta biosynthetic process (GO:0045357)2.85804774
141regulation of histone H3-K27 methylation (GO:0061085)2.85058205
142nuclear pore organization (GO:0006999)2.84948369
143regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83908213
144glycine metabolic process (GO:0006544)2.82697673
145DNA geometric change (GO:0032392)2.82539049
146retinoic acid receptor signaling pathway (GO:0048384)2.82438202
147histone H4-K16 acetylation (GO:0043984)2.81307782
148negative regulation of glycoprotein biosynthetic process (GO:0010561)2.81287773
149intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.80505438
150mitochondrial DNA replication (GO:0006264)2.79278199
151intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.78846906
152branched-chain amino acid catabolic process (GO:0009083)2.78272161
153detection of external biotic stimulus (GO:0098581)2.77963823
154positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.76565941
155drug metabolic process (GO:0017144)2.74925171
156regulation of mast cell degranulation (GO:0043304)2.74709294
157cardiovascular system development (GO:0072358)2.73707478
158leukocyte aggregation (GO:0070486)2.73528684
159NIK/NF-kappaB signaling (GO:0038061)2.73469454
160negative regulation of leukocyte mediated immunity (GO:0002704)2.72301211
161regulation of dendritic cell antigen processing and presentation (GO:0002604)2.72168489
162histone H3-K36 demethylation (GO:0070544)2.71770762
163negative regulation of DNA-templated transcription, elongation (GO:0032785)2.71678422
164cell fate commitment involved in formation of primary germ layer (GO:0060795)2.71539651
165actin nucleation (GO:0045010)2.69699940
166negative regulation of lymphocyte mediated immunity (GO:0002707)2.67385418
167negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.67146102
168positive regulation of histone deacetylation (GO:0031065)2.66176540
169ribonucleoprotein complex biogenesis (GO:0022613)2.64485936
170mitochondrial DNA metabolic process (GO:0032042)2.63706978
171mitotic chromosome condensation (GO:0007076)2.62533992
172retrograde transport, endosome to Golgi (GO:0042147)2.62430472
173histone H3-K9 modification (GO:0061647)2.62392629
174negative regulation of innate immune response (GO:0045824)2.61435454
175interferon-gamma-mediated signaling pathway (GO:0060333)2.60922377
176T cell migration (GO:0072678)2.59736453
177phosphatidylglycerol biosynthetic process (GO:0006655)2.59500693
178CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.59115939
179regulation of amyloid precursor protein catabolic process (GO:1902991)2.58680594
180macrophage activation involved in immune response (GO:0002281)2.58287714
181stress granule assembly (GO:0034063)2.56778727
182regulation of leukocyte degranulation (GO:0043300)2.56083982
183antigen receptor-mediated signaling pathway (GO:0050851)2.54860426
184negative regulation of granulocyte differentiation (GO:0030853)2.52710797
185interferon-gamma secretion (GO:0072643)2.52346221
186positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.51822269
187detection of biotic stimulus (GO:0009595)2.51620655
188positive regulation of Cdc42 GTPase activity (GO:0043089)2.49984324
189defense response to protozoan (GO:0042832)2.48372333
190negative regulation of cell size (GO:0045792)2.47815068
191regulation of ARF protein signal transduction (GO:0032012)2.45409346
192spliceosomal tri-snRNP complex assembly (GO:0000244)2.44696389
193regulation of monocyte differentiation (GO:0045655)2.44614541
194regulation of beta-amyloid formation (GO:1902003)2.43220510
195regulation of hydrogen peroxide metabolic process (GO:0010310)2.42918810
196regulation of superoxide anion generation (GO:0032928)2.42570892
197B cell mediated immunity (GO:0019724)2.42442200
198negative regulation of myotube differentiation (GO:0010832)2.42285666
1993-UTR-mediated mRNA stabilization (GO:0070935)2.42162335
200negative regulation of bone resorption (GO:0045779)2.41288841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.64074766
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.64074766
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.64074766
4E2F7_22180533_ChIP-Seq_HELA_Human4.56128123
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.31960422
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.73353841
7VDR_21846776_ChIP-Seq_THP-1_Human3.34757501
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.12380682
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.02211858
10LXR_22292898_ChIP-Seq_THP-1_Human2.70099340
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.59738826
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55048234
13* MYC_18555785_ChIP-Seq_MESCs_Mouse2.53707816
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.42182377
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.36027006
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.31127402
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.25162682
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14207931
19KDM2B_26808549_Chip-Seq_DND41_Human2.13985663
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.12415945
21TCF7_22412390_ChIP-Seq_EML_Mouse2.10089381
22* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09340544
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07711494
24TP63_19390658_ChIP-ChIP_HaCaT_Human2.06776707
25SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.05614629
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.02418870
27UTX_26944678_Chip-Seq_JUKART_Human1.98920569
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.98442136
29P68_20966046_ChIP-Seq_HELA_Human1.97759337
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97440322
31MAF_26560356_Chip-Seq_TH1_Human1.96808995
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96768111
33* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96697221
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95731492
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.95297406
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.95175767
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93531616
38MAF_26560356_Chip-Seq_TH2_Human1.92429742
39* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92353838
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.92074770
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.91385023
42VDR_24763502_ChIP-Seq_THP-1_Human1.91060064
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88212252
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82936357
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81939780
46TCF3_18692474_ChIP-Seq_MESCs_Mouse1.81090402
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.80910547
48BCL6_27268052_Chip-Seq_Bcells_Human1.78941303
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.78490048
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.76057254
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75274258
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74762159
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74549821
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73148023
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.72649785
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71423770
57RACK7_27058665_Chip-Seq_MCF-7_Human1.67896200
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67453087
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.67020350
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66116159
61BCOR_27268052_Chip-Seq_Bcells_Human1.64954979
62* SMC4_20622854_ChIP-Seq_HELA_Human1.64575300
63NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.63143353
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.62470922
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.61755371
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59049334
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.58782367
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58244033
69IRF1_19129219_ChIP-ChIP_H3396_Human1.55531349
70* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52214593
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51680650
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51652271
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51334652
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.50455792
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.50115061
76PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48919804
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47957265
78* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46210704
79EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44903322
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43918829
81MYC_22102868_ChIP-Seq_BL_Human1.43809516
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43275583
83RXR_22158963_ChIP-Seq_LIVER_Mouse1.43006260
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41670363
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.40299667
86* SPI1_23127762_ChIP-Seq_K562_Human1.40004141
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.39013465
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39004938
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38311125
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38169973
91SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36733126
92* KDM2B_26808549_Chip-Seq_JURKAT_Human1.35689609
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.34782021
94* SPI1_23547873_ChIP-Seq_NB4_Human1.34061475
95CREB1_26743006_Chip-Seq_LNCaP_Human1.32809384
96PHF8_20622854_ChIP-Seq_HELA_Human1.32505407
97E2F1_20622854_ChIP-Seq_HELA_Human1.32490358
98* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32215348
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31505231
100OCT4_18692474_ChIP-Seq_MEFs_Mouse1.31093401
101* FOXP3_21729870_ChIP-Seq_TREG_Human1.30882963
102XRN2_22483619_ChIP-Seq_HELA_Human1.29548806
103RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29283312
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28275452
105STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28122408
106KDM2B_26808549_Chip-Seq_K562_Human1.27735189
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26800701
108POU5F1_16518401_ChIP-PET_MESCs_Mouse1.26710577
109SCL_19346495_ChIP-Seq_HPC-7_Human1.25808496
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24786041
111IRF8_21731497_ChIP-ChIP_J774_Mouse1.24660808
112* CTCF_26484167_Chip-Seq_Bcells_Mouse1.24590630
113* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24199312
114BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23883294
115NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.23864495
116MYB_26560356_Chip-Seq_TH1_Human1.23507180
117POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.22888446
118SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21709703
119SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20685455
120ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20088680
121GABP_19822575_ChIP-Seq_HepG2_Human1.19336935
122CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19016368
123NANOG_18692474_ChIP-Seq_MEFs_Mouse1.18522636
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17898546
125ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17795445
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17610663
127CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17531715
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17440440
129NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17256493
130* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16835772
131NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16536847
132* MYB_26560356_Chip-Seq_TH2_Human1.16381813
133STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16332648
134* RARB_24833708_ChIP-Seq_LIVER_Mouse1.16228759
135FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15859041
136GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15609164
137ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13849921
138SA1_27219007_Chip-Seq_Bcells_Human1.13462159
139IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13238267
140HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13173269
141PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12962872
142CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12899475
143PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12807427
144* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.12640342
145* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12406907
146CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11448310
147TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10813594
148SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09458491
149SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08880767
150RUNX1_27514584_Chip-Seq_MCF-7_Human1.08507781
151ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06318325
152TP63_17297297_ChIP-ChIP_HaCaT_Human1.06192023
153FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05952640
154ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05612030
155TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.05152811
156KDM5A_27292631_Chip-Seq_BREAST_Human1.04943129
157TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03320493
158ETS1_21867929_ChIP-Seq_TH2_Mouse1.02752032
159KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02052634
160NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01479281
161NANOG_21062744_ChIP-ChIP_HESCs_Human0.99976224
162* VDR_23849224_ChIP-Seq_CD4+_Human0.99669005
163NOTCH1_21737748_ChIP-Seq_TLL_Human0.98144542
164MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98050920
165* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97632007
166PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96040338
167YY1_22570637_ChIP-Seq_MALME-3M_Human0.95759602
168E2F1_17053090_ChIP-ChIP_MCF-7_Human0.95165318
169CIITA_25753668_ChIP-Seq_RAJI_Human0.93764868
170FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93151674
171TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.92742958
172TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91935750
173* DCP1A_22483619_ChIP-Seq_HELA_Human0.90921269
174THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89986624
175NCOR1_26117541_ChIP-Seq_K562_Human0.88040036
176KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87291480
177LXR_22158963_ChIP-Seq_LIVER_Mouse0.86571093
178EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86451192
179TTF2_22483619_ChIP-Seq_HELA_Human0.85711853
180AR_21909140_ChIP-Seq_LNCAP_Human0.85525979
181HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.84765622
182STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84453249
183NANOG_16518401_ChIP-PET_MESCs_Mouse0.83548884
184SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83542884
185NANOG_16153702_ChIP-ChIP_HESCs_Human0.83181208
186E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82962400
187ELF1_20517297_ChIP-Seq_JURKAT_Human0.82706376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.33055962
2MP0004264_abnormal_extraembryonic_tissu4.30032571
3MP0003436_decreased_susceptibility_to4.01868586
4MP0005058_abnormal_lysosome_morphology3.97524025
5MP0003172_abnormal_lysosome_physiology3.86131580
6MP0002254_reproductive_system_inflammat3.67736454
7MP0006292_abnormal_olfactory_placode3.50827070
8MP0001835_abnormal_antigen_presentation3.06730432
9MP0004957_abnormal_blastocyst_morpholog2.99716413
10MP0005075_abnormal_melanosome_morpholog2.96603342
11MP0003890_abnormal_embryonic-extraembry2.95549717
12MP0003806_abnormal_nucleotide_metabolis2.83011458
13MP0009278_abnormal_bone_marrow2.76423610
14MP0001800_abnormal_humoral_immune2.73468012
15MP0000685_abnormal_immune_system2.56502525
16MP0008057_abnormal_DNA_replication2.55509127
17MP0005387_immune_system_phenotype2.46759416
18MP0001790_abnormal_immune_system2.46759416
19MP0005025_abnormal_response_to2.44889288
20MP0003763_abnormal_thymus_physiology2.38140419
21MP0003705_abnormal_hypodermis_morpholog2.34931376
22MP0005000_abnormal_immune_tolerance2.33402048
23MP0002139_abnormal_hepatobiliary_system2.29817990
24MP0006035_abnormal_mitochondrial_morpho2.29679872
25MP0003303_peritoneal_inflammation2.28530855
26MP0008260_abnormal_autophagy2.28429141
27MP0002419_abnormal_innate_immunity2.27939928
28MP0005671_abnormal_response_to2.26476304
29MP0002723_abnormal_immune_serum2.26409911
30MP0005394_taste/olfaction_phenotype2.23005186
31MP0005499_abnormal_olfactory_system2.23005186
32MP0005365_abnormal_bile_salt2.22816981
33MP0002420_abnormal_adaptive_immunity2.17077287
34MP0001819_abnormal_immune_cell2.15657751
35MP0010352_gastrointestinal_tract_polyps2.13775190
36MP0000678_abnormal_parathyroid_gland2.12445165
37MP0002452_abnormal_antigen_presenting2.11597968
38MP0005360_urolithiasis2.06690374
39MP0004858_abnormal_nervous_system2.00380513
40MP0002653_abnormal_ependyma_morphology1.94016068
41MP0010155_abnormal_intestine_physiology1.92048986
42MP0002398_abnormal_bone_marrow1.88609298
43MP0003724_increased_susceptibility_to1.88519887
44MP0003183_abnormal_peptide_metabolism1.85442475
45MP0000716_abnormal_immune_system1.83434483
46MP0005085_abnormal_gallbladder_physiolo1.82891215
47MP0002332_abnormal_exercise_endurance1.80115613
48MP0005257_abnormal_intraocular_pressure1.79393965
49MP0003122_maternal_imprinting1.78411003
50MP0009785_altered_susceptibility_to1.76851726
51MP0002405_respiratory_system_inflammati1.72077148
52MP0008875_abnormal_xenobiotic_pharmacok1.69133381
53MP0004947_skin_inflammation1.67896895
54MP0009333_abnormal_splenocyte_physiolog1.65623994
55MP0005380_embryogenesis_phenotype1.61820538
56MP0001672_abnormal_embryogenesis/_devel1.61820538
57MP0003077_abnormal_cell_cycle1.59685561
58MP0005464_abnormal_platelet_physiology1.56517926
59MP0000703_abnormal_thymus_morphology1.53984136
60MP0002429_abnormal_blood_cell1.52815242
61MP0002722_abnormal_immune_system1.52764457
62MP0003693_abnormal_embryo_hatching1.52085639
63MP0001533_abnormal_skeleton_physiology1.52073965
64MP0005451_abnormal_body_composition1.51685367
65MP0002088_abnormal_embryonic_growth/wei1.51411496
66MP0003866_abnormal_defecation1.50554268
67MP0000689_abnormal_spleen_morphology1.50043629
68MP0003984_embryonic_growth_retardation1.49834891
69MP0002148_abnormal_hypersensitivity_rea1.48913855
70MP0001873_stomach_inflammation1.43536291
71MP0004043_abnormal_pH_regulation1.42688423
72MP0005266_abnormal_metabolism1.40793811
73MP0005397_hematopoietic_system_phenotyp1.40316199
74MP0001545_abnormal_hematopoietic_system1.40316199
75MP0001845_abnormal_inflammatory_respons1.38285884
76MP0003111_abnormal_nucleus_morphology1.38181076
77MP0008961_abnormal_basal_metabolism1.38179814
78MP0005319_abnormal_enzyme/_coenzyme1.35987607
79MP0003690_abnormal_glial_cell1.35913764
80MP0010030_abnormal_orbit_morphology1.35786860
81MP0003121_genomic_imprinting1.35768822
82MP0001853_heart_inflammation1.33075256
83MP0001849_ear_inflammation1.32568871
84MP0001293_anophthalmia1.32245474
85MP0000350_abnormal_cell_proliferation1.31925199
86MP0003186_abnormal_redox_activity1.29926520
87MP0008469_abnormal_protein_level1.27433044
88MP0002933_joint_inflammation1.24945807
89MP0006036_abnormal_mitochondrial_physio1.22599324
90MP0002092_abnormal_eye_morphology1.22151312
91MP0002396_abnormal_hematopoietic_system1.20104761
92MP0002970_abnormal_white_adipose1.19296206
93MP0002932_abnormal_joint_morphology1.18814921
94MP0010094_abnormal_chromosome_stability1.18644334
95MP0001986_abnormal_taste_sensitivity1.18037519
96MP0000609_abnormal_liver_physiology1.17181010
97MP0002086_abnormal_extraembryonic_tissu1.16538377
98MP0003252_abnormal_bile_duct1.16440866
99MP0006082_CNS_inflammation1.15431085
100MP0005076_abnormal_cell_differentiation1.13885894
101MP0003329_amyloid_beta_deposits1.13691476
102MP0002127_abnormal_cardiovascular_syste1.13079619
103MP0004133_heterotaxia1.12045963
104MP0009840_abnormal_foam_cell1.10749248
105MP0002132_abnormal_respiratory_system1.10482280
106MP0001730_embryonic_growth_arrest1.08387113
107MP0002085_abnormal_embryonic_tissue1.07465050
108MP0005666_abnormal_adipose_tissue1.05695016
109MP0003300_gastrointestinal_ulcer1.05575168
110MP0003938_abnormal_ear_development1.05159438
111MP0000490_abnormal_crypts_of1.03211845
112MP0005083_abnormal_biliary_tract1.01418511
113MP0004185_abnormal_adipocyte_glucose1.00332084
114MP0008007_abnormal_cellular_replicative1.00297800
115MP0003123_paternal_imprinting0.99817525
116MP0000604_amyloidosis0.98776839
117MP0000762_abnormal_tongue_morphology0.97708634
118MP0002277_abnormal_respiratory_mucosa0.97283564
119MP0003283_abnormal_digestive_organ0.95695845
120MP0004808_abnormal_hematopoietic_stem0.95005397
121MP0008932_abnormal_embryonic_tissue0.94698399
122MP0010329_abnormal_lipoprotein_level0.94472952
123MP0004197_abnormal_fetal_growth/weight/0.93934122
124MP0005332_abnormal_amino_acid0.93398181
125MP0002084_abnormal_developmental_patter0.92500931
126MP0000313_abnormal_cell_death0.91942072
127MP0002080_prenatal_lethality0.91925049
128MP0000358_abnormal_cell_content/0.91895272
129MP0000049_abnormal_middle_ear0.91478073
130MP0005310_abnormal_salivary_gland0.90652154
131MP0001663_abnormal_digestive_system0.90378622
132MP0002998_abnormal_bone_remodeling0.89664494
133MP0003119_abnormal_digestive_system0.89181228
134MP0000598_abnormal_liver_morphology0.89063637
135MP0009764_decreased_sensitivity_to0.87864611
136MP0001697_abnormal_embryo_size0.87831590
137MP0005023_abnormal_wound_healing0.87439439
138MP0008789_abnormal_olfactory_epithelium0.84845604
139MP0003656_abnormal_erythrocyte_physiolo0.84678675
140MP0001666_abnormal_nutrient_absorption0.84053184
141MP0002877_abnormal_melanocyte_morpholog0.84034353
142MP0004381_abnormal_hair_follicle0.83920171
143MP0002138_abnormal_hepatobiliary_system0.83179089
144MP0009379_abnormal_foot_pigmentation0.82378647
145MP0002233_abnormal_nose_morphology0.81691949
146MP0002269_muscular_atrophy0.76790972
147MP0002249_abnormal_larynx_morphology0.75537060
148MP0005376_homeostasis/metabolism_phenot0.74605183
149MP0002019_abnormal_tumor_incidence0.74165413
150MP0001348_abnormal_lacrimal_gland0.73917855
151MP0002114_abnormal_axial_skeleton0.73065438
152MP0005375_adipose_tissue_phenotype0.71958009
153MP0000003_abnormal_adipose_tissue0.71336039
154MP0002166_altered_tumor_susceptibility0.69897337
155MP0009115_abnormal_fat_cell0.69462556
156MP0000428_abnormal_craniofacial_morphol0.69368108
157MP0005248_abnormal_Harderian_gland0.69306407
158MP0005535_abnormal_body_temperature0.68947666
159MP0008058_abnormal_DNA_repair0.68685820
160MP0008995_early_reproductive_senescence0.68351931
161MP0001764_abnormal_homeostasis0.67884808
162MP0009643_abnormal_urine_homeostasis0.67752900
163MP0005391_vision/eye_phenotype0.65750527
164MP0003191_abnormal_cellular_cholesterol0.65733340
165MP0001243_abnormal_dermal_layer0.64901461
166MP0000858_altered_metastatic_potential0.64837738
167MP0003315_abnormal_perineum_morphology0.64698110
168MP0003786_premature_aging0.64330200
169MP0000681_abnormal_thyroid_gland0.63027848
170MP0000477_abnormal_intestine_morphology0.61709254
171MP0002089_abnormal_postnatal_growth/wei0.60780958
172MP0005390_skeleton_phenotype0.60753360
173MP0002136_abnormal_kidney_physiology0.60231606
174MP0002822_catalepsy0.59737254

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.27501570
2Hypochromic microcytic anemia (HP:0004840)5.99642682
3Multiple enchondromatosis (HP:0005701)5.79244789
4Hepatoblastoma (HP:0002884)4.98376548
5Abnormality of the lower motor neuron (HP:0002366)4.44917487
6Ependymoma (HP:0002888)4.34924232
7Hyperinsulinemic hypoglycemia (HP:0000825)4.19201836
8Colitis (HP:0002583)4.09137635
9Rib fusion (HP:0000902)3.97002040
10Eczematoid dermatitis (HP:0000976)3.90856824
11Panhypogammaglobulinemia (HP:0003139)3.84908260
12Agammaglobulinemia (HP:0004432)3.82195096
13J-shaped sella turcica (HP:0002680)3.77057211
14Ragged-red muscle fibers (HP:0003200)3.70595497
15Dysostosis multiplex (HP:0000943)3.61759345
16Abnormality of the intrinsic pathway (HP:0010989)3.61676173
17Abnormal cartilage morphology (HP:0002763)3.58560066
18Rhabdomyosarcoma (HP:0002859)3.52989410
19Reduced antithrombin III activity (HP:0001976)3.52509978
20Neoplasm of striated muscle (HP:0009728)3.45799410
21Elevated erythrocyte sedimentation rate (HP:0003565)3.27972696
22Recurrent abscess formation (HP:0002722)3.26453355
23Increased IgE level (HP:0003212)3.22750196
24Myositis (HP:0100614)3.20867255
25Recurrent fungal infections (HP:0002841)3.18439833
26Testicular atrophy (HP:0000029)3.16458574
27Chronic obstructive pulmonary disease (HP:0006510)3.13461374
28Obstructive lung disease (HP:0006536)3.13461374
29Gastrointestinal inflammation (HP:0004386)3.12849700
30Meningitis (HP:0001287)3.09579838
31Nephroblastoma (Wilms tumor) (HP:0002667)3.08350505
32Recurrent gram-negative bacterial infections (HP:0005420)3.07787063
33Chromosomal breakage induced by crosslinking agents (HP:0003221)3.07451817
34Mediastinal lymphadenopathy (HP:0100721)3.06799012
35Recurrent bacterial skin infections (HP:0005406)3.03203438
36Trismus (HP:0000211)2.97999274
37Urinary glycosaminoglycan excretion (HP:0003541)2.97519069
38Mucopolysacchariduria (HP:0008155)2.97519069
39Abnormality of macrophages (HP:0004311)2.96862315
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.92662872
41Hypoplasia of the fovea (HP:0007750)2.92662872
42Abnormality of polysaccharide metabolism (HP:0011012)2.91947448
43Abnormality of glycosaminoglycan metabolism (HP:0004371)2.91947448
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.91947448
45Metaphyseal cupping (HP:0003021)2.91944200
46Recurrent viral infections (HP:0004429)2.91245516
47Systemic lupus erythematosus (HP:0002725)2.90999511
48Broad face (HP:0000283)2.90789610
49Abnormality of the salivary glands (HP:0010286)2.89727387
50Partial duplication of thumb phalanx (HP:0009944)2.87723478
51Inflammation of the large intestine (HP:0002037)2.87158508
52Embryonal renal neoplasm (HP:0011794)2.83184140
53Aplastic anemia (HP:0001915)2.81894426
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.80793668
55Progressive muscle weakness (HP:0003323)2.80772054
56Hypochromic anemia (HP:0001931)2.78075481
57Chronic mucocutaneous candidiasis (HP:0002728)2.75849252
58Recurrent cutaneous fungal infections (HP:0011370)2.75849252
59Hyperglycinuria (HP:0003108)2.73580690
60Cellulitis (HP:0100658)2.72102526
61Abnormality of the astrocytes (HP:0100707)2.70104917
62Astrocytoma (HP:0009592)2.70104917
63Fused cervical vertebrae (HP:0002949)2.66944984
64Increased cerebral lipofuscin (HP:0011813)2.66388256
65Abnormality of lateral ventricle (HP:0030047)2.66076263
66Papilledema (HP:0001085)2.65029949
67Abnormal lung lobation (HP:0002101)2.63757444
68Chromsome breakage (HP:0040012)2.63077575
69Type I transferrin isoform profile (HP:0003642)2.61183260
70Bifid tongue (HP:0010297)2.58566753
71Cervical subluxation (HP:0003308)2.58535357
72Malnutrition (HP:0004395)2.56380070
73Rectal fistula (HP:0100590)2.56126603
74Rectovaginal fistula (HP:0000143)2.56126603
75Obstructive sleep apnea (HP:0002870)2.55281032
76Seborrheic dermatitis (HP:0001051)2.54468624
77Microretrognathia (HP:0000308)2.54002701
78Gastrointestinal infarctions (HP:0005244)2.51879961
79Partial duplication of the phalanx of hand (HP:0009999)2.50650050
80Biconcave vertebral bodies (HP:0004586)2.50645232
81Amyotrophic lateral sclerosis (HP:0007354)2.50473358
82Abnormality of aromatic amino acid family metabolism (HP:0004338)2.49472727
83Encephalitis (HP:0002383)2.49218319
84Hemorrhage of the eye (HP:0011885)2.48787441
85Abnormality of the thoracic spine (HP:0100711)2.48511847
86Aplasia/hypoplasia of the humerus (HP:0006507)2.47594504
87Broad distal phalanx of finger (HP:0009836)2.45968306
88Thoracic kyphosis (HP:0002942)2.45547168
89Vasculitis (HP:0002633)2.44808676
90Increased neuronal autofluorescent lipopigment (HP:0002074)2.44635028
91Orchitis (HP:0100796)2.43536653
92Vaginal fistula (HP:0004320)2.43377402
93Pustule (HP:0200039)2.42910780
94Impulsivity (HP:0100710)2.42075499
95Microvesicular hepatic steatosis (HP:0001414)2.40151794
963-Methylglutaconic aciduria (HP:0003535)2.39092864
97Abnormality of the fingertips (HP:0001211)2.35906329
98Recurrent skin infections (HP:0001581)2.35771603
99Neurodegeneration (HP:0002180)2.35735722
100Gout (HP:0001997)2.34591839
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.34574662
102Short humerus (HP:0005792)2.34168482
103Deep venous thrombosis (HP:0002625)2.31218525
104Granulocytopenia (HP:0001913)2.29771209
105Hypertensive crisis (HP:0100735)2.29234463
106Abnormality of glycolysis (HP:0004366)2.29148799
107Increased serum pyruvate (HP:0003542)2.29148799
108Preauricular skin tag (HP:0000384)2.29109334
10911 pairs of ribs (HP:0000878)2.28577523
110Glomerulonephritis (HP:0000099)2.28224195
111Tetraplegia (HP:0002445)2.28126353
112Gastrointestinal stroma tumor (HP:0100723)2.28025916
113Anomalous pulmonary venous return (HP:0010772)2.25425665
114Thin bony cortex (HP:0002753)2.23933287
115Abnormality of small intestinal villus morphology (HP:0011472)2.23270758
116Villous atrophy (HP:0011473)2.23270758
117Intrahepatic cholestasis (HP:0001406)2.22978224
118Abnormality of serine family amino acid metabolism (HP:0010894)2.20721780
119Abnormality of glycine metabolism (HP:0010895)2.20721780
120Loss of speech (HP:0002371)2.19189263
121Abnormality of monocarboxylic acid metabolism (HP:0010996)2.18589206
122Hepatosplenomegaly (HP:0001433)2.18296983
123Intestinal fistula (HP:0100819)2.17637473
124Skin nodule (HP:0200036)2.17106739
125Nasal polyposis (HP:0100582)2.16383755
126Hyperacusis (HP:0010780)2.15600627
127Gingivitis (HP:0000230)2.14947427
128Pancreatic islet-cell hyperplasia (HP:0004510)2.14938929
129Premature ovarian failure (HP:0008209)2.14523801
130Optic neuritis (HP:0100653)2.14286321
131Retrobulbar optic neuritis (HP:0100654)2.14286321
132Recurrent sinusitis (HP:0011108)2.13419155
133Abnormality of the peritoneum (HP:0002585)2.11488702
134Polygenic inheritance (HP:0010982)2.11083225
135Abnormality of the fovea (HP:0000493)2.10617770
136Meckel diverticulum (HP:0002245)2.09906732
137Pseudobulbar signs (HP:0002200)2.08268331
138Hand muscle atrophy (HP:0009130)2.08225939
139Abnormality of complement system (HP:0005339)2.05887904
140Combined immunodeficiency (HP:0005387)2.04894109
141Glossoptosis (HP:0000162)2.04628533
142Complement deficiency (HP:0004431)2.04456350
143Aplasia/Hypoplasia of the macula (HP:0008059)2.04260389
144Flattened epiphyses (HP:0003071)2.01875083
145Shawl scrotum (HP:0000049)2.01342265
146Pulmonary infiltrates (HP:0002113)2.01092609
147Upper motor neuron abnormality (HP:0002127)2.01000495
148Lymphopenia (HP:0001888)2.00366362
149Short 5th finger (HP:0009237)1.99901708
150Neuronal loss in central nervous system (HP:0002529)1.99327917
151Supernumerary ribs (HP:0005815)1.99280131
152Interstitial pulmonary disease (HP:0006530)1.98084899
153Missing ribs (HP:0000921)1.98069487
154Aplasia/Hypoplasia of the uvula (HP:0010293)1.97118846
155Deformed sella turcica (HP:0002681)1.96995420
156Horizontal nystagmus (HP:0000666)1.96509844
157Skin tags (HP:0010609)1.95842110
158Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95578216
159Abnormal gallbladder physiology (HP:0012438)1.95400638
160Cholecystitis (HP:0001082)1.95400638
161Increased serum ferritin (HP:0003281)1.95190786
162Flat acetabular roof (HP:0003180)1.95156169
163Glioma (HP:0009733)1.95038477
164Abnormality of the ileum (HP:0001549)1.94767263
165Medulloblastoma (HP:0002885)1.94245391
166Secondary amenorrhea (HP:0000869)1.94209468
167Angiofibromas (HP:0010615)1.94125326
168Adenoma sebaceum (HP:0009720)1.94125326
169Cerebral aneurysm (HP:0004944)1.93652505
170Emphysema (HP:0002097)1.93154206
171Tongue fasciculations (HP:0001308)1.89804995
172Generalized hypotonia (HP:0001290)1.89426207
173Prolonged bleeding time (HP:0003010)1.88934220
174Hyperammonemia (HP:0001987)1.88504058
175Cerebral palsy (HP:0100021)1.88104754
176Joint stiffness (HP:0001387)1.87735446
177Aplasia/Hypoplasia affecting the retina (HP:0008061)1.87217369
178Stridor (HP:0010307)1.85741419
179Abnormality of the pulmonary veins (HP:0011718)1.85457080
180Supernumerary spleens (HP:0009799)1.85365201
181Abnormality of the pleura (HP:0002103)1.85082530
182Hypergammaglobulinemia (HP:0010702)1.84380669
183Supernumerary bones of the axial skeleton (HP:0009144)1.84175559
184Atelectasis (HP:0100750)1.84001562
185Atrophy/Degeneration involving motor neurons (HP:0007373)1.82410563
186Purpura (HP:0000979)1.81695586
187Abnormality of the pancreatic islet cells (HP:0006476)1.81665517
188Abnormality of endocrine pancreas physiology (HP:0012093)1.81665517
189Abnormality of the nasal mucosa (HP:0000433)1.81232426
190Abnormality of cells of the lymphoid lineage (HP:0012140)1.80730624
191Abnormality of the musculature of the hand (HP:0001421)1.79971005
192Ketoacidosis (HP:0001993)1.79655721
193Hypopigmentation of the fundus (HP:0007894)1.78852643
194Hyperventilation (HP:0002883)1.76995029
195Ketosis (HP:0001946)1.76736121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.16270279
2ERN15.99078414
3GRK54.34401060
4GRK64.25121000
5MAP4K13.36279171
6RIPK42.97319300
7GRK12.78792305
8CSF1R2.70556326
9ADRBK22.68055866
10TGFBR22.49933890
11TTK2.49650644
12TYK22.38880208
13SIK22.37724513
14MAP2K32.18828764
15TNK22.15584684
16STK102.15212179
17BCKDK2.11885290
18PRPF4B2.10016878
19TYRO32.01824564
20MAPK72.00023961
21MATK1.92701122
22MAP3K131.91473305
23EPHA21.80468093
24SMG11.77606309
25GRK71.77343437
26CDK71.72381418
27BUB11.62075524
28FES1.56785011
29BTK1.56222164
30MOS1.54919144
31MAP3K141.54878611
32TBK11.54177251
33JAK31.49116790
34PAK41.44622939
35TAOK31.41955699
36PRKG21.38867230
37TESK21.36657336
38MAP3K101.35293670
39PTK61.29478596
40AKT31.28201468
41MAP3K61.27076674
42WNK11.25784617
43KIT1.23515909
44IKBKE1.23163968
45MAPK151.22702244
46CDC42BPA1.21796171
47FLT31.21335109
48CAMK41.21167359
49SYK1.19430602
50PLK11.18259731
51IRAK41.17491926
52PRKD21.16989229
53MAP2K21.16927838
54CHEK21.11732895
55NTRK11.11681058
56SIK31.11002968
57MAP3K111.07970876
58WEE11.07940123
59HIPK21.04595701
60NEK21.01737507
61CAMKK10.98113936
62RPS6KB20.96630011
63MARK20.94311024
64MAPK110.90698819
65LYN0.90436134
66PDPK10.90215990
67PDK10.89422927
68LCK0.88285318
69RIPK10.87317802
70MAP2K60.84478604
71HCK0.83848900
72ADRBK10.83410581
73SIK10.81576793
74RET0.79715460
75PRKCI0.79135883
76CSK0.78329428
77CDC70.77773466
78JAK20.77606067
79CHEK10.77021335
80MAPKAPK30.75052654
81PASK0.71905748
82RPS6KC10.71826949
83RPS6KL10.71826949
84JAK10.70786812
85FGFR30.70326041
86CDK40.69915597
87AKT20.68237787
88NME10.67414271
89AURKA0.67202461
90MAP2K40.65735982
91DYRK30.63717726
92MTOR0.63055700
93EPHB10.62204790
94FGR0.61507282
95MAP3K70.61049986
96NTRK20.60059347
97MARK30.59939513
98RPS6KA60.59320377
99MST1R0.58185760
100BMX0.57841789
101AURKB0.56738117
102RPS6KA20.56141494
103NME20.55773329
104EIF2AK30.53534354
105ITK0.51213360
106FYN0.50831147
107DYRK1A0.50721051
108TRIB30.50588867
109NEK10.49126496
110ALK0.48554616
111PDK20.48313647
112PRKD30.48157191
113EIF2AK20.48140674
114TAOK10.47253027
115CHUK0.46350219
116CDK20.46076164
117MAPK30.45869367
118PDGFRA0.43903193
119TLK10.43834450
120FGFR20.43365229
121MAP3K10.42784056
122PTK20.42728320
123STK160.42528813
124PAK10.40231535
125PDK40.39734677
126PDK30.39734677
127MAPKAPK20.39557214
128PRKCQ0.38680260
129TXK0.38247371
130DYRK1B0.37827624
131IGF1R0.37538293
132MAPK120.36443690
133SRPK10.36390302
134FGFR40.34011884
135ZAP700.33753821
136PIM20.33632682
137KDR0.32995919
138EEF2K0.31915239
139ERBB20.31801630
140ATM0.31135915
141ATR0.29016882
142PRKCD0.28394424
143PKN20.25250309
144DYRK20.25191946
145CSNK1E0.25103223
146BLK0.24786392
147MET0.23730988
148BRSK20.23499061
149MAP3K80.22016204
150CDK10.20689473
151ICK0.20655959
152LRRK20.20348383
153MAP3K30.19675351
154MAPK40.19427471
155GSK3A0.18470922
156TESK10.18152800
157EIF2AK10.17739438
158MAPK10.17686398
159PIM10.17620615
160CDK80.17473746
161IKBKB0.16399241

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.44915078
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.07116390
3Fructose and mannose metabolism_Homo sapiens_hsa000512.96355462
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81882077
5Staphylococcus aureus infection_Homo sapiens_hsa051502.60274546
6Primary immunodeficiency_Homo sapiens_hsa053402.59548100
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46300733
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.42195861
9Leishmaniasis_Homo sapiens_hsa051402.35337381
10Allograft rejection_Homo sapiens_hsa053302.30332977
11B cell receptor signaling pathway_Homo sapiens_hsa046622.24355536
12Galactose metabolism_Homo sapiens_hsa000522.23574745
13Autoimmune thyroid disease_Homo sapiens_hsa053202.19879024
14Graft-versus-host disease_Homo sapiens_hsa053322.15049150
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14531158
16One carbon pool by folate_Homo sapiens_hsa006702.09680792
17Notch signaling pathway_Homo sapiens_hsa043302.04755220
18Asthma_Homo sapiens_hsa053102.04183047
19Folate biosynthesis_Homo sapiens_hsa007902.01086992
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98760755
21Tryptophan metabolism_Homo sapiens_hsa003801.96115613
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.95558297
23Acute myeloid leukemia_Homo sapiens_hsa052211.91732996
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.89591391
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.87019097
26Ribosome_Homo sapiens_hsa030101.86951227
27Osteoclast differentiation_Homo sapiens_hsa043801.82689358
28DNA replication_Homo sapiens_hsa030301.81176835
29Selenocompound metabolism_Homo sapiens_hsa004501.80551786
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79890537
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72183018
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68358409
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66775429
34Chemical carcinogenesis_Homo sapiens_hsa052041.63856738
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63000127
36Arachidonic acid metabolism_Homo sapiens_hsa005901.60456088
37Mismatch repair_Homo sapiens_hsa034301.60008992
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.56280637
39Non-small cell lung cancer_Homo sapiens_hsa052231.54618268
40Antigen processing and presentation_Homo sapiens_hsa046121.50600172
41Pentose phosphate pathway_Homo sapiens_hsa000301.49146054
42Linoleic acid metabolism_Homo sapiens_hsa005911.48999082
43Type I diabetes mellitus_Homo sapiens_hsa049401.48850625
44Biosynthesis of amino acids_Homo sapiens_hsa012301.44847790
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43382769
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43256956
47VEGF signaling pathway_Homo sapiens_hsa043701.43253863
48RNA transport_Homo sapiens_hsa030131.41316173
49Sulfur relay system_Homo sapiens_hsa041221.40989858
50Herpes simplex infection_Homo sapiens_hsa051681.39930176
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.39501540
52Carbon metabolism_Homo sapiens_hsa012001.39039774
53Influenza A_Homo sapiens_hsa051641.37770161
54Tuberculosis_Homo sapiens_hsa051521.36554323
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35261937
56Complement and coagulation cascades_Homo sapiens_hsa046101.35160032
57Drug metabolism - other enzymes_Homo sapiens_hsa009831.32602344
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32535171
59Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32458486
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31886772
61T cell receptor signaling pathway_Homo sapiens_hsa046601.26080006
62Chronic myeloid leukemia_Homo sapiens_hsa052201.22743618
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22676088
64Lysosome_Homo sapiens_hsa041421.21914274
65Fatty acid degradation_Homo sapiens_hsa000711.20968691
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.20650130
67Toxoplasmosis_Homo sapiens_hsa051451.19275509
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19235180
69Cyanoamino acid metabolism_Homo sapiens_hsa004601.17760521
70Hepatitis C_Homo sapiens_hsa051601.12918121
71Choline metabolism in cancer_Homo sapiens_hsa052311.12913248
72Hematopoietic cell lineage_Homo sapiens_hsa046401.11763849
73NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10774497
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10766854
75Arginine biosynthesis_Homo sapiens_hsa002201.10318506
76Homologous recombination_Homo sapiens_hsa034401.09629266
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09071835
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04770538
79Base excision repair_Homo sapiens_hsa034101.04554042
80Other glycan degradation_Homo sapiens_hsa005111.04390669
81Measles_Homo sapiens_hsa051621.03855401
82Spliceosome_Homo sapiens_hsa030401.01629724
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99683736
84Peroxisome_Homo sapiens_hsa041460.95847891
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95111111
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.94925131
87Viral myocarditis_Homo sapiens_hsa054160.94482311
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.93468955
89Protein export_Homo sapiens_hsa030600.91924646
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91360685
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91161991
92Hepatitis B_Homo sapiens_hsa051610.90995099
93TNF signaling pathway_Homo sapiens_hsa046680.90599688
94Prolactin signaling pathway_Homo sapiens_hsa049170.89636480
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87583615
96Pyrimidine metabolism_Homo sapiens_hsa002400.87305991
97Sulfur metabolism_Homo sapiens_hsa009200.87175446
98Retinol metabolism_Homo sapiens_hsa008300.86970647
99Pyruvate metabolism_Homo sapiens_hsa006200.85792222
100Pancreatic cancer_Homo sapiens_hsa052120.85231106
101Fanconi anemia pathway_Homo sapiens_hsa034600.83738966
102Pertussis_Homo sapiens_hsa051330.83134699
103Chemokine signaling pathway_Homo sapiens_hsa040620.81987356
104Thyroid cancer_Homo sapiens_hsa052160.80789459
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.79966603
106Fat digestion and absorption_Homo sapiens_hsa049750.79949334
107Propanoate metabolism_Homo sapiens_hsa006400.79417721
108Nitrogen metabolism_Homo sapiens_hsa009100.79093178
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77552092
110RNA polymerase_Homo sapiens_hsa030200.77419543
111Proteasome_Homo sapiens_hsa030500.76276187
112Glutathione metabolism_Homo sapiens_hsa004800.75432689
113Histidine metabolism_Homo sapiens_hsa003400.74612466
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74191448
115Epstein-Barr virus infection_Homo sapiens_hsa051690.74130789
116PPAR signaling pathway_Homo sapiens_hsa033200.73885230
117Starch and sucrose metabolism_Homo sapiens_hsa005000.72421359
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.71809224
119Cell cycle_Homo sapiens_hsa041100.71372171
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71279524
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.70802084
122GnRH signaling pathway_Homo sapiens_hsa049120.70536472
123Apoptosis_Homo sapiens_hsa042100.69346659
124RNA degradation_Homo sapiens_hsa030180.69242360
125Prion diseases_Homo sapiens_hsa050200.68222440
126Butanoate metabolism_Homo sapiens_hsa006500.66954512
127Tyrosine metabolism_Homo sapiens_hsa003500.66809693
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.66663804
129beta-Alanine metabolism_Homo sapiens_hsa004100.65516981
130Metabolic pathways_Homo sapiens_hsa011000.64727341
131mRNA surveillance pathway_Homo sapiens_hsa030150.64157278
132HTLV-I infection_Homo sapiens_hsa051660.61267118
133Arginine and proline metabolism_Homo sapiens_hsa003300.61084178
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60309912
135Nucleotide excision repair_Homo sapiens_hsa034200.60221127
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58587934
137Fatty acid metabolism_Homo sapiens_hsa012120.58537588
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.57534987
139Insulin resistance_Homo sapiens_hsa049310.56313299
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54400707
141ABC transporters_Homo sapiens_hsa020100.54250446
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53690118
143Rheumatoid arthritis_Homo sapiens_hsa053230.53684918
144Lysine degradation_Homo sapiens_hsa003100.53288741
145Endometrial cancer_Homo sapiens_hsa052130.52665326
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51992873
147Phenylalanine metabolism_Homo sapiens_hsa003600.51382946
148Inositol phosphate metabolism_Homo sapiens_hsa005620.51180209
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50685496
150HIF-1 signaling pathway_Homo sapiens_hsa040660.49772924
151Platelet activation_Homo sapiens_hsa046110.49201457
152Phagosome_Homo sapiens_hsa041450.48885193
153Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47610128
154Glycerolipid metabolism_Homo sapiens_hsa005610.47058785
155p53 signaling pathway_Homo sapiens_hsa041150.46833639
156ErbB signaling pathway_Homo sapiens_hsa040120.45889106
157Sphingolipid signaling pathway_Homo sapiens_hsa040710.45476794
158Endocytosis_Homo sapiens_hsa041440.44431967
159Basal transcription factors_Homo sapiens_hsa030220.43518524
160SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43393357
161mTOR signaling pathway_Homo sapiens_hsa041500.42104869
162Caffeine metabolism_Homo sapiens_hsa002320.41874185
163Malaria_Homo sapiens_hsa051440.41586689
164Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40948617
165Non-homologous end-joining_Homo sapiens_hsa034500.40848043
166Insulin signaling pathway_Homo sapiens_hsa049100.40760316
167Regulation of autophagy_Homo sapiens_hsa041400.40263208
168Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39707190
169Bile secretion_Homo sapiens_hsa049760.36514702
170Central carbon metabolism in cancer_Homo sapiens_hsa052300.35897485
171Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35692456
172Glioma_Homo sapiens_hsa052140.34101141
173Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33480652
174RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33159379
175Bladder cancer_Homo sapiens_hsa052190.32605792
176African trypanosomiasis_Homo sapiens_hsa051430.32230389
177Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31499990
178Estrogen signaling pathway_Homo sapiens_hsa049150.31039987
179Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28548982
180Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28394586
181Shigellosis_Homo sapiens_hsa051310.27879757
182Glycerophospholipid metabolism_Homo sapiens_hsa005640.26151406

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