CDK6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.26581698
2V(D)J recombination (GO:0033151)6.17366292
3ribosomal small subunit assembly (GO:0000028)6.12834780
4nuclear pore organization (GO:0006999)5.94329486
5negative regulation of thymocyte apoptotic process (GO:0070244)4.86061349
6DNA strand elongation involved in DNA replication (GO:0006271)4.82901341
7telomere maintenance via semi-conservative replication (GO:0032201)4.76423676
8DNA strand elongation (GO:0022616)4.67230852
9Peyers patch development (GO:0048541)4.63028451
10mucosal-associated lymphoid tissue development (GO:0048537)4.63028451
11pore complex assembly (GO:0046931)4.59587149
12negative regulation of phagocytosis (GO:0050765)4.56001604
13regulation of histone H3-K9 methylation (GO:0051570)4.38859351
14DNA unwinding involved in DNA replication (GO:0006268)4.35020237
15telomere maintenance via recombination (GO:0000722)4.25091819
16DNA replication initiation (GO:0006270)4.13629649
17regulation of RNA export from nucleus (GO:0046831)4.12522795
18DNA deamination (GO:0045006)4.11222718
19mitotic recombination (GO:0006312)3.97180733
20definitive hemopoiesis (GO:0060216)3.96475787
21sister chromatid segregation (GO:0000819)3.82560602
22mitotic chromosome condensation (GO:0007076)3.80335628
23somatic cell DNA recombination (GO:0016444)3.78982243
24somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.78982243
25dosage compensation (GO:0007549)3.78913085
26negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.78832325
27telomere maintenance via telomere lengthening (GO:0010833)3.74653667
28CENP-A containing nucleosome assembly (GO:0034080)3.69855169
29regulation of granulocyte differentiation (GO:0030852)3.68660425
30monoubiquitinated protein deubiquitination (GO:0035520)3.67800078
31granulocyte differentiation (GO:0030851)3.66656930
32DNA topological change (GO:0006265)3.61266642
33nucleotide-excision repair, DNA gap filling (GO:0006297)3.59689162
34positive regulation of mitotic sister chromatid separation (GO:1901970)3.54477816
35positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.54477816
36positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.54477816
37regulation of sister chromatid cohesion (GO:0007063)3.53062195
38somatic diversification of immune receptors (GO:0002200)3.52743698
39protein localization to kinetochore (GO:0034501)3.51055451
40chromatin remodeling at centromere (GO:0031055)3.49835377
41non-recombinational repair (GO:0000726)3.47145323
42double-strand break repair via nonhomologous end joining (GO:0006303)3.47145323
43viral transcription (GO:0019083)3.44477310
44IMP biosynthetic process (GO:0006188)3.43611131
45positive regulation of B cell differentiation (GO:0045579)3.41398230
46kinetochore organization (GO:0051383)3.40437656
47translational termination (GO:0006415)3.34838570
48nuclear envelope disassembly (GO:0051081)3.30243869
49membrane disassembly (GO:0030397)3.30243869
50IMP metabolic process (GO:0046040)3.24755180
51mast cell activation (GO:0045576)3.22454106
52negative regulation of DNA repair (GO:0045738)3.22267580
53rRNA methylation (GO:0031167)3.21946674
54regulation of nucleobase-containing compound transport (GO:0032239)3.20384355
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19907667
56antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.19414518
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.19414518
58regulation of histone H3-K4 methylation (GO:0051569)3.16768620
59mature B cell differentiation involved in immune response (GO:0002313)3.16335741
60DNA replication-independent nucleosome organization (GO:0034724)3.15482163
61DNA replication-independent nucleosome assembly (GO:0006336)3.15482163
62interkinetic nuclear migration (GO:0022027)3.13078859
63megakaryocyte development (GO:0035855)3.13036475
64ribosomal small subunit biogenesis (GO:0042274)3.13034639
65telomere maintenance (GO:0000723)3.12953565
66cotranslational protein targeting to membrane (GO:0006613)3.11701621
67DNA replication checkpoint (GO:0000076)3.09124918
68regulation of DNA damage checkpoint (GO:2000001)3.09115663
69telomere organization (GO:0032200)3.08658462
70protein targeting to ER (GO:0045047)3.07982451
71deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.07534855
72glucocorticoid receptor signaling pathway (GO:0042921)3.07071728
73regulation of nuclear cell cycle DNA replication (GO:0033262)3.05677933
74formation of translation preinitiation complex (GO:0001731)3.04896689
75nucleobase biosynthetic process (GO:0046112)2.99397479
76maturation of SSU-rRNA (GO:0030490)2.99204170
77translational elongation (GO:0006414)2.98436592
78mitotic sister chromatid segregation (GO:0000070)2.97277097
79DNA ligation (GO:0006266)2.97173538
80positive regulation of histone methylation (GO:0031062)2.97156828
81neutrophil mediated immunity (GO:0002446)2.97019298
82protein localization to chromosome, centromeric region (GO:0071459)2.95716165
83negative regulation of erythrocyte differentiation (GO:0045647)2.93738235
84poly(A)+ mRNA export from nucleus (GO:0016973)2.92944404
85mitotic sister chromatid cohesion (GO:0007064)2.92852955
86protein localization to endoplasmic reticulum (GO:0070972)2.91441411
87establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90726459
88DNA synthesis involved in DNA repair (GO:0000731)2.90492640
89hepatocyte differentiation (GO:0070365)2.89772955
90negative regulation of granulocyte differentiation (GO:0030853)2.89453868
91B cell differentiation (GO:0030183)2.89111403
92sister chromatid cohesion (GO:0007062)2.88409733
93translesion synthesis (GO:0019985)2.87943633
94Arp2/3 complex-mediated actin nucleation (GO:0034314)2.84868155
95platelet dense granule organization (GO:0060155)2.83408993
96rRNA modification (GO:0000154)2.83039356
97kinetochore assembly (GO:0051382)2.82390462
98negative regulation of growth of symbiont in host (GO:0044130)2.81944346
99negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.81944346
100modulation of growth of symbiont involved in interaction with host (GO:0044144)2.81944346
101regulation of growth of symbiont in host (GO:0044126)2.81944346
102alternative mRNA splicing, via spliceosome (GO:0000380)2.81864047
103positive regulation of vasculogenesis (GO:2001214)2.81474501
104folic acid-containing compound biosynthetic process (GO:0009396)2.80947609
105negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.80489131
106nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.78626874
107pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.78284448
108regulation of DNA endoreduplication (GO:0032875)2.78254787
109maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.77718658
110RNA-dependent DNA replication (GO:0006278)2.77517077
111centrosome duplication (GO:0051298)2.76864749
112meiotic chromosome segregation (GO:0045132)2.75623704
113positive regulation of chromosome segregation (GO:0051984)2.74089590
114mitotic G2/M transition checkpoint (GO:0044818)2.73738955
115regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.72514904
116DNA duplex unwinding (GO:0032508)2.72334884
117positive regulation by host of viral transcription (GO:0043923)2.70025904
118DNA geometric change (GO:0032392)2.69855755
119mitotic G2 DNA damage checkpoint (GO:0007095)2.68435373
120regulation of thymocyte apoptotic process (GO:0070243)2.68345665
121DNA replication-dependent nucleosome assembly (GO:0006335)2.68017153
122DNA replication-dependent nucleosome organization (GO:0034723)2.68017153
123mitotic nuclear envelope disassembly (GO:0007077)2.67857430
124antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67560690
125histone exchange (GO:0043486)2.67247481
126angiogenesis involved in wound healing (GO:0060055)2.66684944
127positive regulation of gamma-delta T cell activation (GO:0046645)2.65139231
128necroptotic process (GO:0070266)2.64707261
129histamine transport (GO:0051608)2.64628685
130intra-S DNA damage checkpoint (GO:0031573)2.64344428
131viral mRNA export from host cell nucleus (GO:0046784)2.64030238
132antigen processing and presentation of endogenous antigen (GO:0019883)2.62654877
133positive regulation of histone H3-K4 methylation (GO:0051571)2.62621988
134T cell lineage commitment (GO:0002360)2.62151925
135mast cell activation involved in immune response (GO:0002279)2.61748769
136mast cell degranulation (GO:0043303)2.61748769
137replication fork processing (GO:0031297)2.61607594
138telomere maintenance via telomerase (GO:0007004)2.61383651
139translational initiation (GO:0006413)2.59923265
140lymphoid progenitor cell differentiation (GO:0002320)2.59711984
141pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.59068204
142negative regulation of mRNA metabolic process (GO:1903312)2.58865043
143regulation of centriole replication (GO:0046599)2.58743715
144T cell homeostasis (GO:0043029)2.57959425
145negative regulation of cell cycle G2/M phase transition (GO:1902750)2.57729636
146ribosome assembly (GO:0042255)2.57458800
147regulation of establishment of cell polarity (GO:2000114)2.57425363
148negative regulation of RNA splicing (GO:0033119)2.57023322
149cellular protein complex disassembly (GO:0043624)2.56948490
150attachment of spindle microtubules to kinetochore (GO:0008608)2.56460536
151regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.56290475
152purine nucleobase biosynthetic process (GO:0009113)2.55501627
153nuclear-transcribed mRNA catabolic process (GO:0000956)2.54473584
154mismatch repair (GO:0006298)2.52513118
155protein-DNA complex disassembly (GO:0032986)2.52207978
156nucleosome disassembly (GO:0006337)2.52207978
157ribosomal large subunit biogenesis (GO:0042273)2.51628709
158viral life cycle (GO:0019058)2.51017422
159daunorubicin metabolic process (GO:0044597)2.50970779
160polyketide metabolic process (GO:0030638)2.50970779
161doxorubicin metabolic process (GO:0044598)2.50970779
162DNA conformation change (GO:0071103)2.49159801
163cellular response to zinc ion (GO:0071294)2.48646388
164positive regulation of granulocyte differentiation (GO:0030854)2.48589790
165pseudouridine synthesis (GO:0001522)2.46422476
166embryonic hemopoiesis (GO:0035162)2.46159445
167DNA replication (GO:0006260)2.46034872
168establishment of chromosome localization (GO:0051303)2.44827180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.78927378
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59418685
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.38721912
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.04182512
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98899388
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.96033103
7SCL_19346495_ChIP-Seq_HPC-7_Human2.89937306
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80572423
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.66777722
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.59383664
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.53877280
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.52572009
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.50719837
14* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40256254
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.40066902
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37869163
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.27201618
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.25678295
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.24292618
20* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.19696380
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11267550
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.05500292
23HOXB4_20404135_ChIP-ChIP_EML_Mouse2.03724533
24* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03375101
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.02782902
26* EGR1_19374776_ChIP-ChIP_THP-1_Human2.02375887
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.01619347
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00254648
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99598256
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98414512
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95923384
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.92981525
33GATA1_22025678_ChIP-Seq_K562_Human1.92681444
34SPI1_23547873_ChIP-Seq_NB4_Human1.90686407
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90428056
36VDR_23849224_ChIP-Seq_CD4+_Human1.90248039
37FOXP3_21729870_ChIP-Seq_TREG_Human1.88957867
38MYC_22102868_ChIP-Seq_BL_Human1.87007540
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86556622
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.86202192
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.82704664
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81689020
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80850843
44* VDR_21846776_ChIP-Seq_THP-1_Human1.80741134
45* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77363332
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75099838
47CIITA_25753668_ChIP-Seq_RAJI_Human1.74108466
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.73857166
49* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72513304
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.70038357
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67337518
52ELK1_19687146_ChIP-ChIP_HELA_Human1.62801754
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62056330
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61799440
55AR_21909140_ChIP-Seq_LNCAP_Human1.61356025
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58711885
57XRN2_22483619_ChIP-Seq_HELA_Human1.58651101
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56876142
59* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55261533
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51000133
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.48841502
62MYB_26560356_Chip-Seq_TH2_Human1.48455211
63RUNX_20019798_ChIP-Seq_JUKART_Human1.48166831
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.46695150
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.46325105
66* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.46138716
67* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44467679
68* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41169624
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40510976
70MYB_26560356_Chip-Seq_TH1_Human1.39501165
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39182696
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38940084
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38931671
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37622842
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.37133129
76DCP1A_22483619_ChIP-Seq_HELA_Human1.36868254
77EWS_26573619_Chip-Seq_HEK293_Human1.35378437
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34850169
79* VDR_24763502_ChIP-Seq_THP-1_Human1.34834348
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33698929
81TTF2_22483619_ChIP-Seq_HELA_Human1.33017128
82* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31003760
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29690594
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26548860
85* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23529933
86GABP_19822575_ChIP-Seq_HepG2_Human1.23079360
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22335652
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22171676
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21047772
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20864213
91WT1_19549856_ChIP-ChIP_CCG9911_Human1.20263098
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17549753
93MAF_26560356_Chip-Seq_TH1_Human1.17203415
94IRF8_27001747_Chip-Seq_BMDM_Mouse1.15400800
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14474105
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13336102
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11892798
98* UTX_26944678_Chip-Seq_JUKART_Human1.09168475
99* BRD4_25478319_ChIP-Seq_HGPS_Human1.08618040
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.07580588
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07566945
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07485153
103THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06554667
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04597816
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01428146
106FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01160330
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00849428
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98987205
109GATA3_27048872_Chip-Seq_THYMUS_Human0.98651005
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97928702
111KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97123863
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95636279
113PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95402745
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95190005
115POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94906027
116KDM5A_27292631_Chip-Seq_BREAST_Human0.93741768
117TCF7_22412390_ChIP-Seq_EML_Mouse0.93683422
118PU_27001747_Chip-Seq_BMDM_Mouse0.92220926
119* FUS_26573619_Chip-Seq_HEK293_Human0.91933663
120* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91120401
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88185198
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86930748
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86837871
124KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86188804
125IGF1R_20145208_ChIP-Seq_DFB_Human0.82424719
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82370070
127ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81594106
128MYC_18940864_ChIP-ChIP_HL60_Human0.80276064
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77074999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002396_abnormal_hematopoietic_system4.11674337
2MP0008057_abnormal_DNA_replication3.72343153
3MP0010094_abnormal_chromosome_stability3.62370025
4MP0003693_abnormal_embryo_hatching3.13289475
5MP0005397_hematopoietic_system_phenotyp2.92162234
6MP0001545_abnormal_hematopoietic_system2.92162234
7MP0004808_abnormal_hematopoietic_stem2.88343587
8MP0001835_abnormal_antigen_presentation2.80737933
9MP0003111_abnormal_nucleus_morphology2.65137356
10MP0002166_altered_tumor_susceptibility2.58941469
11MP0003077_abnormal_cell_cycle2.48040627
12MP0005174_abnormal_tail_pigmentation2.46361238
13MP0003724_increased_susceptibility_to2.32468202
14MP0008007_abnormal_cellular_replicative2.27702798
15MP0008058_abnormal_DNA_repair2.27229612
16MP0000490_abnormal_crypts_of2.27089681
17MP0002006_tumorigenesis2.22984126
18MP0005464_abnormal_platelet_physiology2.21588827
19MP0005075_abnormal_melanosome_morpholog2.19768408
20* MP0002398_abnormal_bone_marrow2.10701490
21MP0009785_altered_susceptibility_to2.06738629
22MP0000465_gastrointestinal_hemorrhage2.06425776
23MP0005671_abnormal_response_to2.00295929
24MP0003436_decreased_susceptibility_to2.00282561
25MP0004957_abnormal_blastocyst_morpholog1.96636512
26MP0002419_abnormal_innate_immunity1.93967491
27* MP0003763_abnormal_thymus_physiology1.92471054
28MP0002148_abnormal_hypersensitivity_rea1.90242969
29MP0005025_abnormal_response_to1.88940892
30MP0006054_spinal_hemorrhage1.81025730
31* MP0002420_abnormal_adaptive_immunity1.80400724
32MP0001853_heart_inflammation1.77833227
33MP0005000_abnormal_immune_tolerance1.77705987
34* MP0001819_abnormal_immune_cell1.77326633
35MP0001800_abnormal_humoral_immune1.76615903
36MP0002452_abnormal_antigen_presenting1.74589602
37* MP0000716_abnormal_immune_system1.69323980
38* MP0000689_abnormal_spleen_morphology1.68978410
39* MP0002722_abnormal_immune_system1.68235934
40MP0002723_abnormal_immune_serum1.66179358
41MP0002009_preneoplasia1.65260190
42* MP0002429_abnormal_blood_cell1.63561956
43MP0002095_abnormal_skin_pigmentation1.59766953
44MP0010155_abnormal_intestine_physiology1.59055038
45MP0009333_abnormal_splenocyte_physiolog1.55041361
46MP0010352_gastrointestinal_tract_polyps1.51990696
47MP0005076_abnormal_cell_differentiation1.51087653
48MP0004185_abnormal_adipocyte_glucose1.48445915
49MP0002405_respiratory_system_inflammati1.47834235
50MP0010307_abnormal_tumor_latency1.47468630
51* MP0002019_abnormal_tumor_incidence1.44913802
52MP0000685_abnormal_immune_system1.44656796
53MP0003300_gastrointestinal_ulcer1.44264551
54* MP0000703_abnormal_thymus_morphology1.42123312
55MP0004147_increased_porphyrin_level1.41945873
56MP0000858_altered_metastatic_potential1.41738532
57MP0002088_abnormal_embryonic_growth/wei1.40639811
58MP0000015_abnormal_ear_pigmentation1.35500586
59MP0004084_abnormal_cardiac_muscle1.35329849
60MP0009278_abnormal_bone_marrow1.34026773
61MP0005380_embryogenesis_phenotype1.33974223
62MP0001672_abnormal_embryogenesis/_devel1.33974223
63MP0001873_stomach_inflammation1.33366890
64MP0001697_abnormal_embryo_size1.31956962
65MP0005220_abnormal_exocrine_pancreas1.28852862
66MP0003186_abnormal_redox_activity1.27860911
67MP0004134_abnormal_chest_morphology1.26245174
68MP0003786_premature_aging1.23533755
69MP0000313_abnormal_cell_death1.16545428
70MP0001845_abnormal_inflammatory_respons1.15965107
71MP0004381_abnormal_hair_follicle1.15398499
72MP0005409_darkened_coat_color1.14295677
73MP0005387_immune_system_phenotype1.13897732
74MP0001790_abnormal_immune_system1.13897732
75MP0008932_abnormal_embryonic_tissue1.12952254
76MP0000350_abnormal_cell_proliferation1.11368491
77MP0003656_abnormal_erythrocyte_physiolo1.10937191
78MP0002132_abnormal_respiratory_system1.09334419
79MP0003866_abnormal_defecation1.09200925
80MP0003943_abnormal_hepatobiliary_system1.07428508
81MP0002234_abnormal_pharynx_morphology1.06683653
82MP0003385_abnormal_body_wall1.06093428
83MP0003172_abnormal_lysosome_physiology1.05576310
84MP0000343_altered_response_to1.04508814
85MP0008877_abnormal_DNA_methylation1.04291140
86MP0001661_extended_life_span1.03601458
87MP0002084_abnormal_developmental_patter0.97079178
88MP0004197_abnormal_fetal_growth/weight/0.96261904
89MP0003303_peritoneal_inflammation0.95338678
90MP0001533_abnormal_skeleton_physiology0.94139238
91MP0008469_abnormal_protein_level0.93357376
92MP0003950_abnormal_plasma_membrane0.90810063
93MP0003252_abnormal_bile_duct0.90513494
94MP0000569_abnormal_digit_pigmentation0.88150817
95MP0001286_abnormal_eye_development0.88084310
96MP0003315_abnormal_perineum_morphology0.87083721
97MP0000371_diluted_coat_color0.83176447
98MP0005621_abnormal_cell_physiology0.82861246
99MP0002877_abnormal_melanocyte_morpholog0.82049080
100MP0001188_hyperpigmentation0.81470919
101MP0002085_abnormal_embryonic_tissue0.79789251
102MP0005084_abnormal_gallbladder_morpholo0.79680854
103MP0001663_abnormal_digestive_system0.78120538
104MP0003935_abnormal_craniofacial_develop0.78035618
105MP0001784_abnormal_fluid_regulation0.77975783
106MP0009379_abnormal_foot_pigmentation0.77748391
107MP0002075_abnormal_coat/hair_pigmentati0.77515534
108MP0001191_abnormal_skin_condition0.77509402
109MP0001986_abnormal_taste_sensitivity0.76476250
110MP0010630_abnormal_cardiac_muscle0.75162823
111MP0003567_abnormal_fetal_cardiomyocyte0.74778474
112MP0003890_abnormal_embryonic-extraembry0.72193471
113MP0005384_cellular_phenotype0.71705901
114MP0008438_abnormal_cutaneous_collagen0.70985293
115MP0001915_intracranial_hemorrhage0.70677226
116MP0000733_abnormal_muscle_development0.70572436
117MP0000627_abnormal_mammary_gland0.70175784
118MP0009763_increased_sensitivity_to0.69535867
119MP0009697_abnormal_copulation0.69172063
120MP0002925_abnormal_cardiovascular_devel0.68828598
121MP0000598_abnormal_liver_morphology0.68707791
122MP0002060_abnormal_skin_morphology0.68467303
123MP0002128_abnormal_blood_circulation0.68187148
124MP0009931_abnormal_skin_appearance0.66674815
125MP0009764_decreased_sensitivity_to0.66574077
126MP0006292_abnormal_olfactory_placode0.66374414
127MP0001730_embryonic_growth_arrest0.64540546
128MP0004264_abnormal_extraembryonic_tissu0.64453408
129MP0004782_abnormal_surfactant_physiolog0.64361191
130MP0003183_abnormal_peptide_metabolism0.63649022
131MP0001849_ear_inflammation0.63531927
132MP0003718_maternal_effect0.61738015
133MP0003448_altered_tumor_morphology0.61230964
134MP0001764_abnormal_homeostasis0.60614997
135MP0002080_prenatal_lethality0.60340299
136MP0001186_pigmentation_phenotype0.59844474
137MP0008873_increased_physiological_sensi0.59831200
138MP0002086_abnormal_extraembryonic_tissu0.59201085
139MP0003984_embryonic_growth_retardation0.57870389
140MP0010368_abnormal_lymphatic_system0.56091715
141MP0003279_aneurysm0.55797129
142MP0001216_abnormal_epidermal_layer0.55796843
143MP0000462_abnormal_digestive_system0.54168683
144MP0000383_abnormal_hair_follicle0.53925680

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)4.99368177
2Aplastic anemia (HP:0001915)4.81077812
3Severe combined immunodeficiency (HP:0004430)4.79690073
4Abnormal number of erythroid precursors (HP:0012131)4.71467560
5Chromsome breakage (HP:0040012)4.41481132
6Abnormality of cells of the erythroid lineage (HP:0012130)4.37939986
7Petechiae (HP:0000967)4.35381042
8Reticulocytopenia (HP:0001896)4.11347440
9Combined immunodeficiency (HP:0005387)4.02172098
10Thyroiditis (HP:0100646)3.82685281
11Autoimmune hemolytic anemia (HP:0001890)3.67879854
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.67385933
13Prolonged bleeding time (HP:0003010)3.43124924
14IgM deficiency (HP:0002850)3.38058859
15Acute myeloid leukemia (HP:0004808)3.37403966
16Reduced antithrombin III activity (HP:0001976)3.35517380
17Elevated erythrocyte sedimentation rate (HP:0003565)3.32116976
18Papilledema (HP:0001085)3.29372431
19Myelodysplasia (HP:0002863)3.21242819
20Recurrent viral infections (HP:0004429)3.19827890
2111 pairs of ribs (HP:0000878)3.19563236
22Abnormality of the prostate (HP:0008775)3.18440764
23Myositis (HP:0100614)3.18425499
24Recurrent abscess formation (HP:0002722)3.16353284
25Birth length less than 3rd percentile (HP:0003561)3.08322627
26Abnormality of chromosome stability (HP:0003220)3.07736761
27Type I transferrin isoform profile (HP:0003642)3.07361709
28Chronic otitis media (HP:0000389)2.98393461
29Recurrent bacterial skin infections (HP:0005406)2.95056192
30Abnormality of the left ventricular outflow tract (HP:0011103)2.92705876
31Subaortic stenosis (HP:0001682)2.92705876
32Abnormality of the fingertips (HP:0001211)2.89940890
33Acute lymphatic leukemia (HP:0006721)2.87728369
34Nephroblastoma (Wilms tumor) (HP:0002667)2.79645843
35Abnormality of T cell physiology (HP:0011840)2.78068399
36Pallor (HP:0000980)2.77835345
37Agammaglobulinemia (HP:0004432)2.73170286
38Epistaxis (HP:0000421)2.70396505
39Asymmetry of the thorax (HP:0001555)2.69162498
40Embryonal renal neoplasm (HP:0011794)2.66352183
41Abnormality of the thymus (HP:0000777)2.63880821
42Ankyloglossia (HP:0010296)2.60281882
43Periodontitis (HP:0000704)2.57495489
44Recurrent fungal infections (HP:0002841)2.57148911
45Granulocytopenia (HP:0001913)2.55382345
46Bone marrow hypocellularity (HP:0005528)2.53039988
47Clubbing of toes (HP:0100760)2.52267527
48Abnormality of the preputium (HP:0100587)2.52038009
49Hypoplasia of the thymus (HP:0000778)2.50198263
50Deep philtrum (HP:0002002)2.49712126
51Skull defect (HP:0001362)2.48421351
52Meningitis (HP:0001287)2.46922563
53Impaired platelet aggregation (HP:0003540)2.46611086
54Abnormal platelet function (HP:0011869)2.46611086
55Abnormality of the heme biosynthetic pathway (HP:0010472)2.45926194
56Hypoproteinemia (HP:0003075)2.41729500
57Abnormal platelet volume (HP:0011876)2.41054445
58Cystic hygroma (HP:0000476)2.40663490
59Lymphoma (HP:0002665)2.39328417
60Cellulitis (HP:0100658)2.39272507
61Panhypogammaglobulinemia (HP:0003139)2.38857145
62Abnormality of DNA repair (HP:0003254)2.37847495
63Cutis marmorata (HP:0000965)2.36341971
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32875803
65Abnormal protein N-linked glycosylation (HP:0012347)2.32875803
66Abnormal protein glycosylation (HP:0012346)2.32875803
67Abnormal glycosylation (HP:0012345)2.32875803
68Oral leukoplakia (HP:0002745)2.32514555
69Pancytopenia (HP:0001876)2.31582753
70B lymphocytopenia (HP:0010976)2.31225383
71Abnormality of B cell number (HP:0010975)2.31225383
72Sandal gap (HP:0001852)2.30319470
73Abnormality of T cells (HP:0002843)2.26634497
74Pulmonary fibrosis (HP:0002206)2.23711171
75T lymphocytopenia (HP:0005403)2.23152506
76Spondylolisthesis (HP:0003302)2.21792068
77Abnormality of the columella (HP:0009929)2.21284997
78Neutropenia (HP:0001875)2.20877952
79Eosinophilia (HP:0001880)2.20300556
80Chronic obstructive pulmonary disease (HP:0006510)2.17223423
81Obstructive lung disease (HP:0006536)2.17223423
82Poikiloderma (HP:0001029)2.15181222
83Mediastinal lymphadenopathy (HP:0100721)2.14902497
84Abnormality of oral frenula (HP:0000190)2.10995317
85IgG deficiency (HP:0004315)2.10708581
86Increased mean platelet volume (HP:0011877)2.09426152
87Heterotopia (HP:0002282)2.06777141
88Meckel diverticulum (HP:0002245)2.06546486
89Agnosia (HP:0010524)2.06254497
90Gingival bleeding (HP:0000225)2.06243907
91Papillary thyroid carcinoma (HP:0002895)2.05573367
92Aplasia/Hypoplasia of the uvula (HP:0010293)2.05512159
93Overlapping toe (HP:0001845)2.05494541
94Orchitis (HP:0100796)2.05315015
95Leukocytosis (HP:0001974)2.05288652
96Volvulus (HP:0002580)2.04949462
97Encephalitis (HP:0002383)2.04376078
98Prominent nose (HP:0000448)2.01804862
99Abnormal delayed hypersensitivity skin test (HP:0002963)2.00663819
100Cutaneous melanoma (HP:0012056)2.00274044
101Abnormality of the ileum (HP:0001549)2.00228879
102Aplasia/Hypoplasia of the thymus (HP:0010515)1.99593190
103Macrocytic anemia (HP:0001972)1.99271827
104Popliteal pterygium (HP:0009756)1.99004127
105Entropion (HP:0000621)1.98524734
106Amaurosis fugax (HP:0100576)1.98485984
107Albinism (HP:0001022)1.98004330
108Abnormality of the anterior horn cell (HP:0006802)1.96735868
109Degeneration of anterior horn cells (HP:0002398)1.96735868
110Eczematoid dermatitis (HP:0000976)1.96569721
111Short middle phalanx of the 5th finger (HP:0004220)1.96107725
112Medulloblastoma (HP:0002885)1.95834588
113Retrobulbar optic neuritis (HP:0100654)1.95749051
114Optic neuritis (HP:0100653)1.95749051
115Abnormality of T cell number (HP:0011839)1.94851332
116Recurrent skin infections (HP:0001581)1.93835782
117Recurrent bronchitis (HP:0002837)1.93015669
118Spinal cord lesions (HP:0100561)1.93007880
119Syringomyelia (HP:0003396)1.93007880
120Keratoconjunctivitis sicca (HP:0001097)1.93003556
121Abnormality of eosinophils (HP:0001879)1.92934369
122Long clavicles (HP:0000890)1.91352511
123Colon cancer (HP:0003003)1.89048425
124Missing ribs (HP:0000921)1.87105685
125Duplicated collecting system (HP:0000081)1.86838941
126Dyschromatopsia (HP:0007641)1.86747277
127Abnormality of chromosome segregation (HP:0002916)1.86247061
128Abnormality of the pleura (HP:0002103)1.85784812
129Broad face (HP:0000283)1.85566291
130Viral hepatitis (HP:0006562)1.85215038
131Lymphopenia (HP:0001888)1.83171046
132Small intestinal stenosis (HP:0012848)1.83044586
133Duodenal stenosis (HP:0100867)1.83044586
134Abnormality of the renal collecting system (HP:0004742)1.81485415
135Abnormality of cells of the lymphoid lineage (HP:0012140)1.81006473
136Osteomyelitis (HP:0002754)1.80553032
137Abnormal foot bone ossification (HP:0010675)1.80113593
138Basal ganglia calcification (HP:0002135)1.80086238
139Submucous cleft hard palate (HP:0000176)1.78325538
140Anteriorly placed anus (HP:0001545)1.77603317
141Thickened calvaria (HP:0002684)1.76764310
142Thyroid carcinoma (HP:0002890)1.76477282
143Nervous tissue neoplasm (HP:0030060)1.75595786
144Neuroectodermal neoplasm (HP:0030061)1.75595786
145Neuroepithelial neoplasm (HP:0030063)1.75595786
146Increased nuchal translucency (HP:0010880)1.75251876
147Primitive neuroectodermal tumor (HP:0030065)1.75038236
148Neuroblastic tumors (HP:0004376)1.75038236
149Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.75038236
150Neuroblastoma (HP:0003006)1.75038236
151Relative macrocephaly (HP:0004482)1.74993947
152Cafe-au-lait spot (HP:0000957)1.73907711
153Delayed closure of the anterior fontanelle (HP:0001476)1.72595535
154Long eyelashes (HP:0000527)1.70473244
155Autoimmune thrombocytopenia (HP:0001973)1.69799275
156Anal stenosis (HP:0002025)1.66199101
157Broad palm (HP:0001169)1.65832245
158Intestinal malrotation (HP:0002566)1.65607417
159Hypoplastic iliac wings (HP:0002866)1.64091864
160Embryonal neoplasm (HP:0002898)1.59948956
161Facial hemangioma (HP:0000329)1.59452114
162Somatic mutation (HP:0001428)1.58463404
163Arteriovenous malformation (HP:0100026)1.57556530
164Abnormality of the duodenum (HP:0002246)1.54041812
165Neoplasm of the adrenal cortex (HP:0100641)1.53741293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK122.99118385
2PIM22.93109422
3CDC72.85367143
4STK162.82595322
5KIT2.67900755
6TAOK32.50876422
7TAF12.47641302
8IRAK42.41193113
9WEE12.40480482
10PBK2.40469676
11MAP4K12.32769319
12TEC2.32738752
13NUAK12.17405390
14BTK2.08854444
15BRSK22.07201682
16VRK11.99847432
17TXK1.94765962
18SRPK11.91015309
19EEF2K1.88379277
20MAP3K101.80326183
21NME21.79880469
22MKNK11.77005159
23FLT31.69894869
24ATR1.68772457
25EIF2AK11.65352959
26CLK11.60764099
27BUB11.54098022
28RPS6KB21.52862416
29PIM11.51190957
30ZAK1.51093303
31SMG11.45948517
32MAP2K31.44511333
33CCNB11.44054862
34MAP3K121.43873974
35MAP3K141.43082397
36TSSK61.41815130
37LATS11.35729363
38CDK81.34694691
39ACVR1B1.31030560
40STK41.30351559
41TNIK1.29744116
42JAK31.29677736
43NEK21.28842261
44MATK1.28136237
45TGFBR11.27470492
46PASK1.26396367
47ZAP701.25106215
48MKNK21.21268480
49CDK41.18193738
50EIF2AK31.15901137
51WNK11.15403637
52FGFR31.09599795
53STK31.08480970
54RPS6KA41.07633034
55SCYL21.06511038
56MAPK111.05919232
57SYK1.05657667
58VRK21.05311325
59CDK91.04408067
60PLK41.03280958
61AURKB1.02996440
62TRPM71.02438586
63MELK0.98569184
64CSF1R0.97895267
65DYRK30.95726744
66STK100.93670718
67MAPKAPK50.90800997
68AKT30.90121304
69MAP3K70.88652213
70PDGFRA0.88375934
71CDK60.87056073
72PLK10.87043858
73TYK20.86837123
74EIF2AK20.85204186
75IKBKE0.85152599
76TTK0.84237507
77RPS6KA60.84211173
78BLK0.83669900
79HIPK20.81891029
80RPS6KB10.81842260
81MAP3K20.80933731
82LYN0.80772305
83ICK0.78804584
84PRPF4B0.77351452
85BMPR1B0.77249578
86MAP3K60.76721818
87RPS6KC10.76410621
88RPS6KL10.76410621
89PLK30.76246003
90PAK20.76179588
91TBK10.75786781
92NEK90.75521249
93ITK0.75400031
94IKBKB0.75344286
95DAPK10.71979335
96BRSK10.70354234
97IRAK30.70251607
98* CDK70.68881244
99PAK40.68446180
100MAPK40.66468252
101TLK10.66183566
102NEK10.63493103
103ATM0.63410454
104LCK0.62206604
105CHUK0.61022287
106MAP3K80.59383232
107PKN20.58702243
108ERBB30.56691971
109CHEK10.56650052
110CHEK20.54855035
111CDK30.54623527
112CDK10.54217927
113LRRK20.53300026
114STK390.53098842
115RPS6KA50.50981380
116RET0.49023526
117RAF10.47819290
118MTOR0.47095929
119MAP3K40.46041768
120CSNK2A10.44441503
121FES0.44340667
122MAPKAPK30.44249416
123PIK3CA0.43629602
124PIK3CG0.42885730
125CSNK2A20.42139926
126CDK20.41530573
127PRKCQ0.41368853
128MYLK0.40932841
129MST40.40222758
130HCK0.39794652
131NLK0.39761439
132JAK20.39612656
133BRD40.38175716
134MAPK30.34990885
135MAP2K70.31299039

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.40636661
2Mismatch repair_Homo sapiens_hsa034303.94800390
3Base excision repair_Homo sapiens_hsa034103.27035235
4Ribosome_Homo sapiens_hsa030103.17247931
5Homologous recombination_Homo sapiens_hsa034403.15159724
6Non-homologous end-joining_Homo sapiens_hsa034502.70010387
7Nucleotide excision repair_Homo sapiens_hsa034202.40760910
8Spliceosome_Homo sapiens_hsa030402.33810126
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26242073
10Fanconi anemia pathway_Homo sapiens_hsa034602.23917987
11* Cell cycle_Homo sapiens_hsa041102.09635664
12One carbon pool by folate_Homo sapiens_hsa006702.08135475
13Pyrimidine metabolism_Homo sapiens_hsa002402.05671294
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98752289
15RNA polymerase_Homo sapiens_hsa030201.86765698
16* Pancreatic cancer_Homo sapiens_hsa052121.79661042
17Alcoholism_Homo sapiens_hsa050341.78003164
18RNA transport_Homo sapiens_hsa030131.75278646
19RNA degradation_Homo sapiens_hsa030181.74847080
20Leishmaniasis_Homo sapiens_hsa051401.52449603
21Herpes simplex infection_Homo sapiens_hsa051681.52441037
22Primary immunodeficiency_Homo sapiens_hsa053401.50505540
23* Non-small cell lung cancer_Homo sapiens_hsa052231.48106648
24Proteasome_Homo sapiens_hsa030501.39227350
25Hematopoietic cell lineage_Homo sapiens_hsa046401.38347940
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36246284
27N-Glycan biosynthesis_Homo sapiens_hsa005101.29658461
28Antigen processing and presentation_Homo sapiens_hsa046121.27905998
29* Measles_Homo sapiens_hsa051621.25899972
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.24958063
31Protein export_Homo sapiens_hsa030601.22539709
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18664639
33Prostate cancer_Homo sapiens_hsa052151.15688505
34Legionellosis_Homo sapiens_hsa051341.14253750
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12350822
36Systemic lupus erythematosus_Homo sapiens_hsa053221.11539384
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10656338
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.09889106
39* p53 signaling pathway_Homo sapiens_hsa041151.09675605
40Purine metabolism_Homo sapiens_hsa002301.05971975
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05970637
42Pentose phosphate pathway_Homo sapiens_hsa000301.05766200
43Asthma_Homo sapiens_hsa053101.05383416
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04878932
45Dorso-ventral axis formation_Homo sapiens_hsa043201.03141706
46mRNA surveillance pathway_Homo sapiens_hsa030151.01071462
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97781424
48Basal transcription factors_Homo sapiens_hsa030220.97547455
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94845149
50Bladder cancer_Homo sapiens_hsa052190.91995529
51Endometrial cancer_Homo sapiens_hsa052130.90183365
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90096801
53B cell receptor signaling pathway_Homo sapiens_hsa046620.89761885
54Influenza A_Homo sapiens_hsa051640.89560780
55Thyroid cancer_Homo sapiens_hsa052160.88395829
56Acute myeloid leukemia_Homo sapiens_hsa052210.88055765
57Epstein-Barr virus infection_Homo sapiens_hsa051690.87190381
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84684041
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83549927
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83489360
61Other glycan degradation_Homo sapiens_hsa005110.81749011
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81519694
63Apoptosis_Homo sapiens_hsa042100.81186423
64* Viral carcinogenesis_Homo sapiens_hsa052030.79420487
65Pertussis_Homo sapiens_hsa051330.79218777
66* Glioma_Homo sapiens_hsa052140.78973936
67* Hepatitis B_Homo sapiens_hsa051610.78547167
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.78155319
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76068784
70Allograft rejection_Homo sapiens_hsa053300.74547251
71Inositol phosphate metabolism_Homo sapiens_hsa005620.73304066
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71889332
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70930039
74Toxoplasmosis_Homo sapiens_hsa051450.67994460
75Osteoclast differentiation_Homo sapiens_hsa043800.67837875
76Platelet activation_Homo sapiens_hsa046110.66575447
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65737961
78Focal adhesion_Homo sapiens_hsa045100.63129788
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.62956896
80HTLV-I infection_Homo sapiens_hsa051660.62904398
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.62478218
82Prolactin signaling pathway_Homo sapiens_hsa049170.62322736
83Galactose metabolism_Homo sapiens_hsa000520.62161095
84Renal cell carcinoma_Homo sapiens_hsa052110.61811836
85Adherens junction_Homo sapiens_hsa045200.61741707
86* Small cell lung cancer_Homo sapiens_hsa052220.60649920
87* Melanoma_Homo sapiens_hsa052180.59503195
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58701033
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58666005
90* Pathways in cancer_Homo sapiens_hsa052000.58347765
91Oocyte meiosis_Homo sapiens_hsa041140.58122670
92Shigellosis_Homo sapiens_hsa051310.58025886
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56669346
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55921955
95mTOR signaling pathway_Homo sapiens_hsa041500.55076311
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54984172
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54427892
98Viral myocarditis_Homo sapiens_hsa054160.54025959
99ErbB signaling pathway_Homo sapiens_hsa040120.52177707
100TGF-beta signaling pathway_Homo sapiens_hsa043500.52006811
101FoxO signaling pathway_Homo sapiens_hsa040680.51779554
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51119449
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50737785
104Tuberculosis_Homo sapiens_hsa051520.50428515
105* Chronic myeloid leukemia_Homo sapiens_hsa052200.50274839
106Malaria_Homo sapiens_hsa051440.49381185
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48990129
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.48640356
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48351780
110Folate biosynthesis_Homo sapiens_hsa007900.48298456
111Renin-angiotensin system_Homo sapiens_hsa046140.47752628
112Wnt signaling pathway_Homo sapiens_hsa043100.46560840
113TNF signaling pathway_Homo sapiens_hsa046680.45513002
114ECM-receptor interaction_Homo sapiens_hsa045120.45112467
115Selenocompound metabolism_Homo sapiens_hsa004500.44636611
116Proteoglycans in cancer_Homo sapiens_hsa052050.44095385
117Glutathione metabolism_Homo sapiens_hsa004800.37850255
118* MicroRNAs in cancer_Homo sapiens_hsa052060.37189137
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.37140904
120Sulfur relay system_Homo sapiens_hsa041220.35954618
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35230042
122Caffeine metabolism_Homo sapiens_hsa002320.33968604
123Long-term depression_Homo sapiens_hsa047300.31327080
124* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30839217
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.29859208
126Salmonella infection_Homo sapiens_hsa051320.29628557
127Lysine degradation_Homo sapiens_hsa003100.29609500
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28517173
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27733944
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.27241886
131Choline metabolism in cancer_Homo sapiens_hsa052310.26843209
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26517032
133Amoebiasis_Homo sapiens_hsa051460.25705631
134Hippo signaling pathway_Homo sapiens_hsa043900.25592568
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.25198028
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24698644
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24536126
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24480203
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24064048
140Colorectal cancer_Homo sapiens_hsa052100.23157285
141T cell receptor signaling pathway_Homo sapiens_hsa046600.22735943

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