CDK7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)4.24562505
2mitotic metaphase plate congression (GO:0007080)4.18691418
3regulation of DNA methylation (GO:0044030)4.11545278
4proteasome assembly (GO:0043248)4.03392126
5kinetochore assembly (GO:0051382)3.88790838
6maturation of SSU-rRNA (GO:0030490)3.86326883
7rRNA modification (GO:0000154)3.84623985
8CENP-A containing nucleosome assembly (GO:0034080)3.83553370
9kinetochore organization (GO:0051383)3.79882681
10regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.73560774
11regulation of mitotic spindle checkpoint (GO:1903504)3.73560774
12meiotic cell cycle (GO:0051321)3.70231989
13ribosome biogenesis (GO:0042254)3.69270093
14metaphase plate congression (GO:0051310)3.65821285
15chromatin remodeling at centromere (GO:0031055)3.65599177
16piRNA metabolic process (GO:0034587)3.64239005
17nucleobase biosynthetic process (GO:0046112)3.63599987
18* termination of RNA polymerase I transcription (GO:0006363)3.62878502
19* transcription elongation from RNA polymerase I promoter (GO:0006362)3.60175087
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.59762696
21purine nucleobase biosynthetic process (GO:0009113)3.58736208
22termination of RNA polymerase III transcription (GO:0006386)3.54599648
23transcription elongation from RNA polymerase III promoter (GO:0006385)3.54599648
24chaperone-mediated protein transport (GO:0072321)3.50728967
25ribonucleoprotein complex biogenesis (GO:0022613)3.48545704
26ribosomal small subunit assembly (GO:0000028)3.47043950
27rRNA methylation (GO:0031167)3.45963975
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.42922764
29ribosomal large subunit biogenesis (GO:0042273)3.41729288
30centriole replication (GO:0007099)3.31807267
31protein localization to kinetochore (GO:0034501)3.30236982
32DNA replication initiation (GO:0006270)3.29908866
33mitotic chromosome condensation (GO:0007076)3.29788284
34* 7-methylguanosine mRNA capping (GO:0006370)3.29656359
35positive regulation of chromosome segregation (GO:0051984)3.28945334
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28840914
37* 7-methylguanosine RNA capping (GO:0009452)3.28520466
38* RNA capping (GO:0036260)3.28520466
39spliceosomal snRNP assembly (GO:0000387)3.28298366
40* transcription from RNA polymerase I promoter (GO:0006360)3.27814340
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27150578
42rRNA processing (GO:0006364)3.27045889
43positive regulation of histone H3-K4 methylation (GO:0051571)3.26776448
44synapsis (GO:0007129)3.26429580
45telomere maintenance via semi-conservative replication (GO:0032201)3.24429683
46spindle checkpoint (GO:0031577)3.23408303
47DNA replication-independent nucleosome organization (GO:0034724)3.22722172
48DNA replication-independent nucleosome assembly (GO:0006336)3.22722172
49ribosome assembly (GO:0042255)3.20575440
50viral mRNA export from host cell nucleus (GO:0046784)3.18877234
51spliceosomal complex assembly (GO:0000245)3.18797275
52DNA replication checkpoint (GO:0000076)3.18615693
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18274492
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18274492
55rRNA metabolic process (GO:0016072)3.16725227
56* transcription-coupled nucleotide-excision repair (GO:0006283)3.16287490
57positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16001439
58regulation of spindle organization (GO:0090224)3.15914022
59positive regulation of mitotic sister chromatid separation (GO:1901970)3.12793741
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.12793741
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.12793741
62maturation of 5.8S rRNA (GO:0000460)3.12569157
63* transcription initiation from RNA polymerase I promoter (GO:0006361)3.11258434
64histone exchange (GO:0043486)3.09443892
65telomere maintenance via recombination (GO:0000722)3.08347132
66IMP biosynthetic process (GO:0006188)3.08208125
67DNA strand elongation involved in DNA replication (GO:0006271)3.08042201
68establishment of chromosome localization (GO:0051303)3.07857696
69cullin deneddylation (GO:0010388)3.06830163
70ribosomal small subunit biogenesis (GO:0042274)3.06828374
71mitotic spindle checkpoint (GO:0071174)3.06190324
72DNA double-strand break processing (GO:0000729)3.05546673
73negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.05480234
74protein K6-linked ubiquitination (GO:0085020)3.05313068
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04816734
76regulation of cellular amino acid metabolic process (GO:0006521)3.04356925
77positive regulation of ligase activity (GO:0051351)3.04231283
78paraxial mesoderm development (GO:0048339)3.04149636
79negative regulation of mitotic sister chromatid separation (GO:2000816)3.03679290
80negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03679290
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03679290
82negative regulation of sister chromatid segregation (GO:0033046)3.03679290
83DNA deamination (GO:0045006)3.03123033
84spindle assembly checkpoint (GO:0071173)3.02052499
85regulation of chromosome segregation (GO:0051983)3.01741902
86regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01462242
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00114540
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.99890253
89establishment of integrated proviral latency (GO:0075713)2.99299311
90mitotic spindle assembly checkpoint (GO:0007094)2.99237678
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99132509
92DNA strand elongation (GO:0022616)2.98758179
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.98578743
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98036898
95pseudouridine synthesis (GO:0001522)2.97578807
96regulation of helicase activity (GO:0051095)2.97522908
97mitotic recombination (GO:0006312)2.97059104
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96965620
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96965620
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96965620
101negative regulation of chromosome segregation (GO:0051985)2.96259510
102regulation of ubiquitin-protein transferase activity (GO:0051438)2.95490816
103regulation of spindle checkpoint (GO:0090231)2.95389284
104tRNA methylation (GO:0030488)2.94359201
105signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.93698652
106intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.93698652
107mitotic G2/M transition checkpoint (GO:0044818)2.91914961
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.91289868
109* G1/S transition of mitotic cell cycle (GO:0000082)2.90680277
110* cell cycle G1/S phase transition (GO:0044843)2.90680277
111attachment of spindle microtubules to kinetochore (GO:0008608)2.90656825
112establishment of viral latency (GO:0019043)2.89148075
113regulation of retinoic acid receptor signaling pathway (GO:0048385)2.88715702
114DNA damage response, detection of DNA damage (GO:0042769)2.88612711
115DNA catabolic process, exonucleolytic (GO:0000738)2.88085924
116signal transduction involved in DNA damage checkpoint (GO:0072422)2.87171670
117signal transduction involved in DNA integrity checkpoint (GO:0072401)2.87171670
118protein deneddylation (GO:0000338)2.86213086
119telomere maintenance via telomere lengthening (GO:0010833)2.85851843
120meiotic chromosome segregation (GO:0045132)2.83318692
121formation of translation preinitiation complex (GO:0001731)2.82225546
122regulation of nuclear cell cycle DNA replication (GO:0033262)2.80827001
123microtubule depolymerization (GO:0007019)2.80673363
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79935660
125intra-S DNA damage checkpoint (GO:0031573)2.79193114
126cellular component biogenesis (GO:0044085)2.75927742
127histone mRNA metabolic process (GO:0008334)2.75922852
128protein localization to chromosome, centromeric region (GO:0071459)2.74620809
129regulation of mitotic metaphase/anaphase transition (GO:0030071)2.74118629
130negative regulation of ligase activity (GO:0051352)2.73326002
131negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.73326002
132ncRNA processing (GO:0034470)2.73132604
133ncRNA metabolic process (GO:0034660)2.71673410
134DNA replication-dependent nucleosome assembly (GO:0006335)2.71234440
135DNA replication-dependent nucleosome organization (GO:0034723)2.71234440
136* DNA-templated transcription, termination (GO:0006353)2.71180219
137regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.70430433
138regulation of mitochondrial translation (GO:0070129)2.69281304
139nucleotide-excision repair, DNA gap filling (GO:0006297)2.68921427
140negative regulation of mitosis (GO:0045839)2.68813578
141regulation of mitotic sister chromatid separation (GO:0010965)2.68102119
142regulation of mitotic sister chromatid segregation (GO:0033047)2.68102119
143regulation of sister chromatid segregation (GO:0033045)2.68102119
144mismatch repair (GO:0006298)2.67690679

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.12353551
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.13408133
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.09356934
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.59968577
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.54135250
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34174277
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.26664602
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.23348984
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.92354496
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86856525
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.85628860
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68098781
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66180868
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.65997147
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59904636
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56592787
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51782000
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51093799
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45308554
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.35105325
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34077472
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.32500397
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23219131
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19832157
25* VDR_23849224_ChIP-Seq_CD4+_Human2.14856531
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14851205
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10802881
28* ELK1_19687146_ChIP-ChIP_HELA_Human2.09646081
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.08572448
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08029250
31* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06965387
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00982974
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98385533
34TTF2_22483619_ChIP-Seq_HELA_Human1.95369721
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89798410
36DCP1A_22483619_ChIP-Seq_HELA_Human1.87292988
37XRN2_22483619_ChIP-Seq_HELA_Human1.85504455
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85320632
39* FOXP3_21729870_ChIP-Seq_TREG_Human1.84465660
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79464842
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77007773
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73915087
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71242419
44* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70242522
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.66733150
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66683064
47* GABP_19822575_ChIP-Seq_HepG2_Human1.64304611
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64274808
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62873259
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59374136
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.57204141
52ZNF274_21170338_ChIP-Seq_K562_Hela1.55763387
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53926483
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52689382
55AR_21909140_ChIP-Seq_LNCAP_Human1.50322667
56KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49765974
57KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49765974
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49765974
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48360631
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47148923
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.44402415
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.43301206
63* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.36039892
64* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32466051
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.31912941
66EWS_26573619_Chip-Seq_HEK293_Human1.30367568
67MYC_18940864_ChIP-ChIP_HL60_Human1.29736040
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27017818
69* ELK1_22589737_ChIP-Seq_MCF10A_Human1.25692727
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20453370
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19255625
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19239343
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17126431
74VDR_22108803_ChIP-Seq_LS180_Human1.16875487
75* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15827766
76FUS_26573619_Chip-Seq_HEK293_Human1.14052580
77NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13692809
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12245472
79IRF1_19129219_ChIP-ChIP_H3396_Human1.10613375
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10380227
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.09283266
82CIITA_25753668_ChIP-Seq_RAJI_Human1.06281276
83EZH2_22144423_ChIP-Seq_EOC_Human1.05945426
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.05004794
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04959923
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04538896
87* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03178101
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00569589
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99692482
90SOX17_20123909_ChIP-Seq_XEN_Mouse0.99283043
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90595386
92ELF5_23300383_ChIP-Seq_T47D_Human0.88552761
93POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87901181
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86580289
95P300_19829295_ChIP-Seq_ESCs_Human0.86428376
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85439005
97BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82784238
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82631985
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.81846029
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81642179
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81274245
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80726316
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80656464
104SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80644766
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80587116
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79781079
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78464361
108NFE2_27457419_Chip-Seq_LIVER_Mouse0.77845224
109SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77095610
110SALL4_22934838_ChIP-ChIP_CD34+_Human0.76993126
111PCGF2_27294783_Chip-Seq_NPCs_Mouse0.74993231
112TCF3_18692474_ChIP-Seq_MESCs_Mouse0.74238820
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.74040919
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73682762
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.73213940
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73020878
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.72822494
118FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.71445193
119TP53_22573176_ChIP-Seq_HFKS_Human0.70936343
120KDM5A_27292631_Chip-Seq_BREAST_Human0.70614729
121SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.67406871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.82344262
2MP0006292_abnormal_olfactory_placode3.36635107
3MP0008058_abnormal_DNA_repair3.16933375
4MP0003941_abnormal_skin_development3.15181850
5MP0003111_abnormal_nucleus_morphology2.90353883
6MP0004957_abnormal_blastocyst_morpholog2.89908109
7MP0003123_paternal_imprinting2.85846117
8MP0010094_abnormal_chromosome_stability2.82047734
9MP0008057_abnormal_DNA_replication2.57090032
10MP0005503_abnormal_tendon_morphology2.52939977
11MP0003077_abnormal_cell_cycle2.48214612
12MP0008007_abnormal_cellular_replicative2.40825633
13MP0008932_abnormal_embryonic_tissue2.33954388
14MP0005394_taste/olfaction_phenotype2.08577911
15MP0005499_abnormal_olfactory_system2.08577911
16MP0000566_synostosis2.06620146
17MP0003121_genomic_imprinting1.96374298
18MP0005395_other_phenotype1.93420452
19MP0002102_abnormal_ear_morphology1.93097539
20MP0003786_premature_aging1.91548350
21MP0001188_hyperpigmentation1.86871763
22MP0003950_abnormal_plasma_membrane1.85522641
23MP0002938_white_spotting1.79766127
24MP0000049_abnormal_middle_ear1.76342750
25MP0003315_abnormal_perineum_morphology1.73472363
26MP0003806_abnormal_nucleotide_metabolis1.68873984
27MP0003718_maternal_effect1.67579204
28MP0003136_yellow_coat_color1.67238272
29MP0003186_abnormal_redox_activity1.65519988
30MP0001929_abnormal_gametogenesis1.62882023
31MP0003937_abnormal_limbs/digits/tail_de1.61992728
32MP0010030_abnormal_orbit_morphology1.59981020
33MP0002249_abnormal_larynx_morphology1.55310443
34MP0003122_maternal_imprinting1.52556249
35MP0008438_abnormal_cutaneous_collagen1.45855457
36MP0003938_abnormal_ear_development1.43468170
37MP0003890_abnormal_embryonic-extraembry1.43440807
38MP0009379_abnormal_foot_pigmentation1.41158832
39MP0004133_heterotaxia1.39264378
40MP0009250_abnormal_appendicular_skeleto1.34443006
41MP0001293_anophthalmia1.34256593
42MP0003699_abnormal_female_reproductive1.31762580
43MP0002234_abnormal_pharynx_morphology1.31206078
44MP0008877_abnormal_DNA_methylation1.30393322
45MP0009697_abnormal_copulation1.27243942
46MP0001986_abnormal_taste_sensitivity1.26869545
47MP0002160_abnormal_reproductive_system1.25786165
48MP0002751_abnormal_autonomic_nervous1.24401004
49MP0003385_abnormal_body_wall1.19149670
50MP0005410_abnormal_fertilization1.17002056
51MP0005508_abnormal_skeleton_morphology1.16806529
52MP0000350_abnormal_cell_proliferation1.16793662
53MP0002233_abnormal_nose_morphology1.16195062
54MP0008995_early_reproductive_senescence1.14990967
55MP0002138_abnormal_hepatobiliary_system1.14538641
56MP0010307_abnormal_tumor_latency1.14458969
57MP0006035_abnormal_mitochondrial_morpho1.14155149
58MP0006072_abnormal_retinal_apoptosis1.12999943
59MP0001286_abnormal_eye_development1.10623305
60MP0003755_abnormal_palate_morphology1.10619030
61MP0005379_endocrine/exocrine_gland_phen1.09758986
62MP0005171_absent_coat_pigmentation1.08384662
63MP0003119_abnormal_digestive_system1.07709061
64MP0000647_abnormal_sebaceous_gland1.07111628
65MP0008260_abnormal_autophagy1.06505397
66MP0002796_impaired_skin_barrier1.06464595
67MP0003942_abnormal_urinary_system1.06382373
68MP0010234_abnormal_vibrissa_follicle1.05839878
69MP0002085_abnormal_embryonic_tissue1.05835216
70MP0002210_abnormal_sex_determination1.04388806
71MP0006036_abnormal_mitochondrial_physio1.02039200
72MP0000516_abnormal_urinary_system1.00666443
73MP0005367_renal/urinary_system_phenotyp1.00666443
74MP0003567_abnormal_fetal_cardiomyocyte1.00381789
75MP0002177_abnormal_outer_ear0.99899281
76MP0001730_embryonic_growth_arrest0.98648578
77MP0002161_abnormal_fertility/fecundity0.98645917
78MP0005389_reproductive_system_phenotype0.98619892
79MP0001672_abnormal_embryogenesis/_devel0.96970158
80MP0005380_embryogenesis_phenotype0.96970158
81MP0002111_abnormal_tail_morphology0.96698223
82MP0000358_abnormal_cell_content/0.95753500
83MP0000427_abnormal_hair_cycle0.95721381
84MP0005409_darkened_coat_color0.95122755
85MP0002139_abnormal_hepatobiliary_system0.93297825
86MP0001529_abnormal_vocalization0.91835155
87MP0000428_abnormal_craniofacial_morphol0.91531604
88MP0002116_abnormal_craniofacial_bone0.91189077
89MP0002084_abnormal_developmental_patter0.91172799
90MP0001697_abnormal_embryo_size0.89738184
91MP0002132_abnormal_respiratory_system0.87337159
92MP0002254_reproductive_system_inflammat0.86685500
93MP0002114_abnormal_axial_skeleton0.86637006
94MP0000432_abnormal_head_morphology0.85545974
95MP0004272_abnormal_basement_membrane0.84903199
96MP0001119_abnormal_female_reproductive0.84532131
97MP0001542_abnormal_bone_strength0.84278030
98MP0005501_abnormal_skin_physiology0.83628820
99MP0002653_abnormal_ependyma_morphology0.83063941
100MP0000026_abnormal_inner_ear0.82844705
101MP0001661_extended_life_span0.82840169
102MP0003698_abnormal_male_reproductive0.82574158
103MP0003935_abnormal_craniofacial_develop0.82537497
104MP0001145_abnormal_male_reproductive0.80634787
105MP0004145_abnormal_muscle_electrophysio0.80520813
106MP0004197_abnormal_fetal_growth/weight/0.80159306
107MP0003787_abnormal_imprinting0.79980895
108MP0000313_abnormal_cell_death0.79664425
109MP0001881_abnormal_mammary_gland0.79422630
110MP0008789_abnormal_olfactory_epithelium0.79114966
111MP0002932_abnormal_joint_morphology0.77765963
112MP0000631_abnormal_neuroendocrine_gland0.77057438
113MP0002095_abnormal_skin_pigmentation0.76358320
114MP0000653_abnormal_sex_gland0.76099680
115MP0002396_abnormal_hematopoietic_system0.75840089
116MP0002109_abnormal_limb_morphology0.75558194
117MP0000372_irregular_coat_pigmentation0.75470280
118MP0002282_abnormal_trachea_morphology0.74804068
119MP0003115_abnormal_respiratory_system0.73824908
120MP0002697_abnormal_eye_size0.73353096
121MP0001919_abnormal_reproductive_system0.72051675
122MP0002080_prenatal_lethality0.71023465
123MP0003984_embryonic_growth_retardation0.70408242
124MP0005275_abnormal_skin_tensile0.70190870
125MP0003936_abnormal_reproductive_system0.70113555
126MP0000762_abnormal_tongue_morphology0.69606687
127MP0003195_calcinosis0.69272535
128MP0005360_urolithiasis0.68648457
129MP0002163_abnormal_gland_morphology0.68598608
130MP0002088_abnormal_embryonic_growth/wei0.68072178
131MP0000681_abnormal_thyroid_gland0.67922459
132MP0001485_abnormal_pinna_reflex0.67805373
133MP0000534_abnormal_ureter_morphology0.67393088
134MP0001764_abnormal_homeostasis0.67095240
135MP0001984_abnormal_olfaction0.66631167
136MP0002090_abnormal_vision0.65116908
137MP0001324_abnormal_eye_pigmentation0.61703594
138MP0002086_abnormal_extraembryonic_tissu0.61138386
139MP0003252_abnormal_bile_duct0.58673227
140MP0005085_abnormal_gallbladder_physiolo0.58582629
141MP0005408_hypopigmentation0.57097374
142MP0005084_abnormal_gallbladder_morpholo0.57023023
143MP0005647_abnormal_sex_gland0.56672678
144MP0005551_abnormal_eye_electrophysiolog0.56443768

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.30236804
2Birth length less than 3rd percentile (HP:0003561)4.22189359
3Chromsome breakage (HP:0040012)3.96543965
4Meckel diverticulum (HP:0002245)3.35092085
5Breast hypoplasia (HP:0003187)3.14328099
6Abnormality of the ileum (HP:0001549)3.12067547
7Acute necrotizing encephalopathy (HP:0006965)3.08546659
8Reticulocytopenia (HP:0001896)3.05927837
9Supernumerary spleens (HP:0009799)2.96639977
10Acute encephalopathy (HP:0006846)2.94971731
11Nephroblastoma (Wilms tumor) (HP:0002667)2.94273446
12Colon cancer (HP:0003003)2.92718901
13Embryonal renal neoplasm (HP:0011794)2.92087692
14Increased hepatocellular lipid droplets (HP:0006565)2.89634110
15Methylmalonic acidemia (HP:0002912)2.85521852
16Abnormality of the preputium (HP:0100587)2.83709154
17Patellar aplasia (HP:0006443)2.81633435
18Duplicated collecting system (HP:0000081)2.78382392
19Increased serum pyruvate (HP:0003542)2.77731873
20Absent septum pellucidum (HP:0001331)2.77001567
21Abnormality of the renal collecting system (HP:0004742)2.72706564
22Facial cleft (HP:0002006)2.70483445
23Increased CSF lactate (HP:0002490)2.69495223
24Aplasia/Hypoplasia of the patella (HP:0006498)2.69327175
25Abnormality of methionine metabolism (HP:0010901)2.68136277
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.66872401
27Abnormality of alanine metabolism (HP:0010916)2.65212819
28Hyperalaninemia (HP:0003348)2.65212819
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65212819
30Abnormal lung lobation (HP:0002101)2.61633417
31Abnormality of aspartate family amino acid metabolism (HP:0010899)2.61218898
32Abnormal mitochondria in muscle tissue (HP:0008316)2.61027131
33Cerebral hypomyelination (HP:0006808)2.56784706
34Carpal bone hypoplasia (HP:0001498)2.55093872
35Gonadotropin excess (HP:0000837)2.54524536
36Abnormality of the labia minora (HP:0012880)2.52890728
37Abnormality of abdominal situs (HP:0011620)2.52636242
38Abdominal situs inversus (HP:0003363)2.52636242
39Mitochondrial inheritance (HP:0001427)2.52413950
40Lipid accumulation in hepatocytes (HP:0006561)2.52064375
41Medulloblastoma (HP:0002885)2.51071976
42Progressive macrocephaly (HP:0004481)2.50972954
43Absent radius (HP:0003974)2.50259433
44Abnormality of glycolysis (HP:0004366)2.47916016
45Oligodactyly (hands) (HP:0001180)2.46526583
46Irregular epiphyses (HP:0010582)2.44547674
47Posterior subcapsular cataract (HP:0007787)2.43026762
48Small intestinal stenosis (HP:0012848)2.38873437
49Duodenal stenosis (HP:0100867)2.38873437
50Abnormality of chromosome stability (HP:0003220)2.38782494
51Absent forearm bone (HP:0003953)2.37720072
52Aplasia involving forearm bones (HP:0009822)2.37720072
53Stenosis of the external auditory canal (HP:0000402)2.34980892
54Absent thumb (HP:0009777)2.33186814
55Triphalangeal thumb (HP:0001199)2.31592444
56Sparse eyelashes (HP:0000653)2.30485719
57Abnormality of serum amino acid levels (HP:0003112)2.25746874
58Abnormality of DNA repair (HP:0003254)2.24897835
59Ectopic kidney (HP:0000086)2.23699903
60Hepatic necrosis (HP:0002605)2.22564075
61Premature ovarian failure (HP:0008209)2.21305268
62Hepatocellular necrosis (HP:0001404)2.21220771
63Increased serum lactate (HP:0002151)2.20491561
64Rough bone trabeculation (HP:0100670)2.17934053
65Sensory axonal neuropathy (HP:0003390)2.17465763
66Bifid tongue (HP:0010297)2.15928183
67Septo-optic dysplasia (HP:0100842)2.15674551
68Renal Fanconi syndrome (HP:0001994)2.13750677
69Methylmalonic aciduria (HP:0012120)2.13684031
70Cerebral edema (HP:0002181)2.13631584
71Aplastic anemia (HP:0001915)2.13630991
72Intestinal atresia (HP:0011100)2.12080468
73Cholecystitis (HP:0001082)2.11645962
74Abnormal gallbladder physiology (HP:0012438)2.11645962
75Multiple enchondromatosis (HP:0005701)2.10799741
76Megaloblastic anemia (HP:0001889)2.10320516
77Hyperglycinemia (HP:0002154)2.08554233
78Adrenal hypoplasia (HP:0000835)2.05602251
79Macrocytic anemia (HP:0001972)2.04819669
80Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.03678086
81Aplasia/Hypoplasia of the fovea (HP:0008060)2.03013520
82Hypoplasia of the fovea (HP:0007750)2.03013520
83Azoospermia (HP:0000027)2.01381240
84Horseshoe kidney (HP:0000085)1.98784733
85Short thumb (HP:0009778)1.98134421
86Intrahepatic cholestasis (HP:0001406)1.96961361
87Abnormal number of incisors (HP:0011064)1.96581369
88Abnormal spermatogenesis (HP:0008669)1.95558134
89Abnormality of the duodenum (HP:0002246)1.95008367
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.90755399
91Premature graying of hair (HP:0002216)1.88961231
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.88752195
93Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87670771
94Duplication of thumb phalanx (HP:0009942)1.86779685
95Supernumerary bones of the axial skeleton (HP:0009144)1.86322197
96Lactic acidosis (HP:0003128)1.85747942
97Microvesicular hepatic steatosis (HP:0001414)1.84922004
98Type I transferrin isoform profile (HP:0003642)1.84551148
99Abnormality of sulfur amino acid metabolism (HP:0004339)1.83296098
100Congenital stationary night blindness (HP:0007642)1.81575556
101Absent epiphyses (HP:0010577)1.81152682
102Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81152682
103Spinal cord lesions (HP:0100561)1.80978241
104Syringomyelia (HP:0003396)1.80978241
105Rhabdomyosarcoma (HP:0002859)1.79812539
106Congenital ichthyosiform erythroderma (HP:0007431)1.79567114
107Abnormal protein glycosylation (HP:0012346)1.78911707
108Abnormal glycosylation (HP:0012345)1.78911707
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78911707
110Abnormal protein N-linked glycosylation (HP:0012347)1.78911707
111Abnormality of the fovea (HP:0000493)1.78890984
112Bone marrow hypocellularity (HP:0005528)1.77685831
113Pancreatic fibrosis (HP:0100732)1.76937000
114True hermaphroditism (HP:0010459)1.76834127
115Selective tooth agenesis (HP:0001592)1.76817057
116Cleft eyelid (HP:0000625)1.76786068
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76644944
118Oligodactyly (HP:0012165)1.76301135
119Sloping forehead (HP:0000340)1.75212886
120Flat capital femoral epiphysis (HP:0003370)1.74837694
121Maternal diabetes (HP:0009800)1.74330185
122Hypophosphatemic rickets (HP:0004912)1.73845531
123Oral leukoplakia (HP:0002745)1.71605506
124Wrist flexion contracture (HP:0001239)1.71465277
125Hypoplasia of the radius (HP:0002984)1.70790451
126CNS hypomyelination (HP:0003429)1.69642817
127Abnormal trabecular bone morphology (HP:0100671)1.69615264
128Optic nerve hypoplasia (HP:0000609)1.69304203
129Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69148180
130Aplasia/Hypoplasia of the tibia (HP:0005772)1.68912048
131Congenital, generalized hypertrichosis (HP:0004540)1.67501768
132Abnormality of the septum pellucidum (HP:0007375)1.67152343
133Myelodysplasia (HP:0002863)1.66211274
134Median cleft lip (HP:0000161)1.65860651
135Absent eyebrow (HP:0002223)1.64201357
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63817863
137Hypoplasia of the capital femoral epiphysis (HP:0003090)1.63066691
138Pancreatic cysts (HP:0001737)1.62502433
139Upper limb muscle weakness (HP:0003484)1.62107323
140Genu varum (HP:0002970)1.61475910
141Abnormality of the carotid arteries (HP:0005344)1.60487055
142Abnormality of the incisor (HP:0000676)1.60479910
143Tracheoesophageal fistula (HP:0002575)1.58522888
144Abnormal sex determination (HP:0012244)1.58017645
145Sex reversal (HP:0012245)1.58017645
146Degeneration of anterior horn cells (HP:0002398)1.57677183
147Abnormality of the anterior horn cell (HP:0006802)1.57677183
148Hypoplastic pelvis (HP:0008839)1.56991241
149Short tibia (HP:0005736)1.56762724
150Clubbing of toes (HP:0100760)1.56572756
1513-Methylglutaconic aciduria (HP:0003535)1.56379134
152Tracheomalacia (HP:0002779)1.55858164
153Atresia of the external auditory canal (HP:0000413)1.55272582
154Supernumerary ribs (HP:0005815)1.54545895
155Neoplasm of the pancreas (HP:0002894)1.53275003
156Short middle phalanx of the 5th finger (HP:0004220)1.52526726
157Abnormality of cells of the erythroid lineage (HP:0012130)1.51511757
158Trismus (HP:0000211)1.50540931
159Ureteral duplication (HP:0000073)1.49845988
160Embryonal neoplasm (HP:0002898)1.49747381
161Rib fusion (HP:0000902)1.49663771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.67658217
2MST44.13780444
3STK163.69125711
4SRPK13.54719545
5WEE13.26828054
6TRIM283.09962969
7MKNK23.07128485
8MKNK12.89539182
9EIF2AK12.64843312
10ZAK2.60329713
11VRK22.48719375
12PLK42.39111435
13CDC72.08876491
14EIF2AK32.04201633
15PLK32.04157466
16VRK12.02071312
17CASK1.90009408
18AKT31.87051677
19TSSK61.82213461
20TLK11.81706741
21TTK1.77306551
22PLK11.70812599
23BRSK21.66361634
24EIF2AK21.65089754
25PBK1.56495348
26TNIK1.56324422
27NME21.49775448
28STK38L1.49598252
29PDK21.41396483
30MAP3K91.41026203
31CDK191.36762774
32ATR1.34543224
33ARAF1.31400843
34ERBB41.28895185
35CHEK21.24933677
36ACVR1B1.22759002
37MAP3K121.18334406
38CDK91.17522266
39EPHA21.16792185
40BRAF1.14351228
41AURKB1.13118099
42STK241.11992572
43DYRK31.10419921
44PASK1.08936454
45ERBB31.07156252
46* CDK71.06961123
47TAF11.06888179
48YES11.06052310
49AURKA1.05091841
50PNCK1.03255008
51NUAK11.01475814
52MAP4K20.95169331
53GRK10.93765122
54MET0.93500328
55DYRK20.91756700
56BRSK10.89034163
57ADRBK20.88810402
58NEK20.87184122
59CDK30.86811936
60CCNB10.86586748
61CHEK10.85403250
62NME10.84937285
63BCR0.84758269
64RPS6KB20.82384147
65CSNK1G10.78961705
66STK390.78892514
67MAPK130.78321375
68BRD40.77282288
69LATS20.74895293
70RPS6KA40.73324850
71ATM0.71034733
72PLK20.68589054
73MAP3K80.67860123
74TAOK20.66402732
75STK40.64936764
76BMPR20.64346354
77CDK80.62957785
78CSNK2A10.61401335
79CSNK1G30.60200184
80RPS6KA50.58049481
81NLK0.57939530
82PAK40.56849896
83BMPR1B0.56076578
84OXSR10.55246287
85NEK10.55095505
86FLT30.54807025
87MAP2K70.54529166
88NTRK30.52017830
89* CDK10.51981133
90STK100.51743377
91* NEK60.51501840
92BCKDK0.51285011
93CSNK2A20.51221046
94CLK10.51087605
95MUSK0.50955593
96IRAK30.49593582
97INSRR0.49359131
98IRAK20.47599503
99TGFBR10.47317964
100* CDK20.46266974
101STK30.46064253
102TNK20.46003600
103DDR20.45773774
104FGFR10.45563885
105FRK0.44088859
106CSNK1G20.43629930
107PIM20.42755717
108TIE10.42062218
109MAP3K30.41588027
110LATS10.38765264
111PAK10.38316287
112LIMK10.38176307
113MAP3K130.36392747
114RAF10.34366407
115WNK40.29842055
116CSNK1A10.29278978
117CSNK1E0.29129033
118PINK10.29000402
119PRKDC0.27684077
120CSNK1A1L0.26959781
121ALK0.26294961
122OBSCN0.25405844
123MYLK0.25250746
124TEC0.24379914
125WNK30.24252302
126AKT20.23905637
127ADRBK10.23779216
128SIK30.23527886
129NEK90.23101017
130PRKCG0.23097349
131MELK0.21426708

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.02136633
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.76051797
3Mismatch repair_Homo sapiens_hsa034303.69431597
4DNA replication_Homo sapiens_hsa030303.49942369
5Ribosome_Homo sapiens_hsa030103.37910294
6Proteasome_Homo sapiens_hsa030503.22311022
7Spliceosome_Homo sapiens_hsa030402.99020693
8Fanconi anemia pathway_Homo sapiens_hsa034602.97175075
9Homologous recombination_Homo sapiens_hsa034402.96422766
10RNA transport_Homo sapiens_hsa030132.65318764
11* Nucleotide excision repair_Homo sapiens_hsa034202.64400668
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46674598
13Pyrimidine metabolism_Homo sapiens_hsa002402.42342886
14* Basal transcription factors_Homo sapiens_hsa030222.36250689
15* Cell cycle_Homo sapiens_hsa041102.27355498
16RNA degradation_Homo sapiens_hsa030182.15101994
17Non-homologous end-joining_Homo sapiens_hsa034502.04548395
18Base excision repair_Homo sapiens_hsa034102.04382084
19Protein export_Homo sapiens_hsa030602.02821608
20Purine metabolism_Homo sapiens_hsa002301.74869366
21Propanoate metabolism_Homo sapiens_hsa006401.66236620
22One carbon pool by folate_Homo sapiens_hsa006701.59498823
23mRNA surveillance pathway_Homo sapiens_hsa030151.53993912
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50987148
25Phototransduction_Homo sapiens_hsa047441.47275012
26Pyruvate metabolism_Homo sapiens_hsa006201.46157573
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41907706
28p53 signaling pathway_Homo sapiens_hsa041151.32025190
29Fatty acid elongation_Homo sapiens_hsa000621.25875176
30Steroid biosynthesis_Homo sapiens_hsa001001.19116361
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18837378
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16507533
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16225690
34Caffeine metabolism_Homo sapiens_hsa002321.14959863
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11106503
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09415520
37Huntingtons disease_Homo sapiens_hsa050161.07172467
38Selenocompound metabolism_Homo sapiens_hsa004501.06070162
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05837821
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02451069
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02077522
42Oocyte meiosis_Homo sapiens_hsa041140.99112072
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95007918
44Vitamin B6 metabolism_Homo sapiens_hsa007500.93972199
45Oxidative phosphorylation_Homo sapiens_hsa001900.92606897
46Parkinsons disease_Homo sapiens_hsa050120.91041799
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90393847
48Epstein-Barr virus infection_Homo sapiens_hsa051690.88629839
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88556813
50Basal cell carcinoma_Homo sapiens_hsa052170.88552335
51TGF-beta signaling pathway_Homo sapiens_hsa043500.84490223
52Biosynthesis of amino acids_Homo sapiens_hsa012300.80632484
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80162546
54Carbon metabolism_Homo sapiens_hsa012000.77678558
55Hedgehog signaling pathway_Homo sapiens_hsa043400.75633489
56Folate biosynthesis_Homo sapiens_hsa007900.74714915
57Sulfur metabolism_Homo sapiens_hsa009200.74347561
58Hippo signaling pathway_Homo sapiens_hsa043900.73865550
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73410628
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69787252
61Systemic lupus erythematosus_Homo sapiens_hsa053220.69367535
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67194357
63Sphingolipid metabolism_Homo sapiens_hsa006000.64206148
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63749691
65Arachidonic acid metabolism_Homo sapiens_hsa005900.62766825
66Wnt signaling pathway_Homo sapiens_hsa043100.62578551
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55932857
68MicroRNAs in cancer_Homo sapiens_hsa052060.55880469
69Alcoholism_Homo sapiens_hsa050340.50702562
70Peroxisome_Homo sapiens_hsa041460.49975564
71ECM-receptor interaction_Homo sapiens_hsa045120.49258649
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49235716
73Collecting duct acid secretion_Homo sapiens_hsa049660.48344859
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47280112
75Regulation of autophagy_Homo sapiens_hsa041400.46673018
76HTLV-I infection_Homo sapiens_hsa051660.46078956
77Herpes simplex infection_Homo sapiens_hsa051680.45080079
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44718287
79Arginine and proline metabolism_Homo sapiens_hsa003300.43833162
80Nicotine addiction_Homo sapiens_hsa050330.42337235
81Melanoma_Homo sapiens_hsa052180.42206555
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41030485
83Viral carcinogenesis_Homo sapiens_hsa052030.37145885
84Glutathione metabolism_Homo sapiens_hsa004800.36991413
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36470759
86Alzheimers disease_Homo sapiens_hsa050100.36350935
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.35968671
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35559697
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35382856
90Circadian rhythm_Homo sapiens_hsa047100.34804068
91Butanoate metabolism_Homo sapiens_hsa006500.34524665
92Pathways in cancer_Homo sapiens_hsa052000.33408785
93Autoimmune thyroid disease_Homo sapiens_hsa053200.29566055
94N-Glycan biosynthesis_Homo sapiens_hsa005100.28133296
95Tight junction_Homo sapiens_hsa045300.28098564
96Metabolic pathways_Homo sapiens_hsa011000.27962007
97Protein digestion and absorption_Homo sapiens_hsa049740.27640540
98Retinol metabolism_Homo sapiens_hsa008300.25444831
99Prostate cancer_Homo sapiens_hsa052150.25054118
100Olfactory transduction_Homo sapiens_hsa047400.24260817
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23328175
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22796387
103Cardiac muscle contraction_Homo sapiens_hsa042600.22399874
104Fatty acid degradation_Homo sapiens_hsa000710.22175647
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21637690
106Chemical carcinogenesis_Homo sapiens_hsa052040.21371408
107Ether lipid metabolism_Homo sapiens_hsa005650.21008563
108Taste transduction_Homo sapiens_hsa047420.20505458
109Sulfur relay system_Homo sapiens_hsa041220.20148279
110Thyroid cancer_Homo sapiens_hsa052160.19752321
111Fatty acid metabolism_Homo sapiens_hsa012120.19010535
112beta-Alanine metabolism_Homo sapiens_hsa004100.17330839
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.17030490
114Allograft rejection_Homo sapiens_hsa053300.16936406
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.16791442
116Colorectal cancer_Homo sapiens_hsa052100.16684839
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.16045829
118Small cell lung cancer_Homo sapiens_hsa052220.15671635
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15620759
120Linoleic acid metabolism_Homo sapiens_hsa005910.15332959
121Pentose phosphate pathway_Homo sapiens_hsa000300.15245775
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15001242
123Renin-angiotensin system_Homo sapiens_hsa046140.14991948
124Arginine biosynthesis_Homo sapiens_hsa002200.14810852
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13668988
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13458218
127Nitrogen metabolism_Homo sapiens_hsa009100.13382269
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13364422
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13113248
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12141569
131Vibrio cholerae infection_Homo sapiens_hsa051100.11413866
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11061437
133Asthma_Homo sapiens_hsa053100.10793516
134Vitamin digestion and absorption_Homo sapiens_hsa049770.10403112
135Melanogenesis_Homo sapiens_hsa049160.09639218
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09500362
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.08592687
138Serotonergic synapse_Homo sapiens_hsa047260.07414470
139Type I diabetes mellitus_Homo sapiens_hsa049400.07169299
140Long-term depression_Homo sapiens_hsa047300.07077662
141HIF-1 signaling pathway_Homo sapiens_hsa040660.06277755
142Antigen processing and presentation_Homo sapiens_hsa046120.05977296

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