CDKAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)5.96644769
2protein deneddylation (GO:0000338)5.54982089
3ribosomal small subunit assembly (GO:0000028)4.24811308
4behavioral response to nicotine (GO:0035095)3.81400735
5CENP-A containing nucleosome assembly (GO:0034080)3.64428698
6kinetochore organization (GO:0051383)3.50757193
7telomere maintenance via semi-conservative replication (GO:0032201)3.43851661
8chromatin remodeling at centromere (GO:0031055)3.43258088
9response to pheromone (GO:0019236)3.41951825
10protein complex biogenesis (GO:0070271)3.40139983
11telomere maintenance via recombination (GO:0000722)3.38740704
12kinetochore assembly (GO:0051382)3.36941774
13platelet dense granule organization (GO:0060155)3.32520687
14polyketide metabolic process (GO:0030638)3.32003701
15doxorubicin metabolic process (GO:0044598)3.32003701
16daunorubicin metabolic process (GO:0044597)3.32003701
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.30250482
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.30250482
19NADH dehydrogenase complex assembly (GO:0010257)3.30250482
20mitochondrial respiratory chain complex assembly (GO:0033108)3.28408217
21water-soluble vitamin biosynthetic process (GO:0042364)3.24781252
22meiotic chromosome segregation (GO:0045132)3.23244976
23DNA ligation (GO:0006266)3.23122567
24respiratory chain complex IV assembly (GO:0008535)3.17949593
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.13681469
26somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13681469
27mitotic recombination (GO:0006312)3.13572839
28centriole assembly (GO:0098534)3.09795303
29definitive hemopoiesis (GO:0060216)3.08192237
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.07559765
31neural tube formation (GO:0001841)3.06654752
32DNA deamination (GO:0045006)3.01470283
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.01358008
34proteasome assembly (GO:0043248)3.01315426
35negative regulation of transcription regulatory region DNA binding (GO:2000678)2.98994929
36reciprocal DNA recombination (GO:0035825)2.95532668
37reciprocal meiotic recombination (GO:0007131)2.95532668
38replication fork processing (GO:0031297)2.93206743
39cytochrome complex assembly (GO:0017004)2.92661859
40lymphoid progenitor cell differentiation (GO:0002320)2.91606730
41DNA demethylation (GO:0080111)2.90821038
42tRNA methylation (GO:0030488)2.89509628
43postreplication repair (GO:0006301)2.87893731
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.85336935
45indolalkylamine metabolic process (GO:0006586)2.84701355
46maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84431866
47RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83170378
48protein neddylation (GO:0045116)2.82317577
49magnesium ion transport (GO:0015693)2.80916966
50centriole replication (GO:0007099)2.80869138
51regulation of mitochondrial translation (GO:0070129)2.78639412
52synapsis (GO:0007129)2.78152355
53DNA replication-independent nucleosome organization (GO:0034724)2.76266198
54DNA replication-independent nucleosome assembly (GO:0006336)2.76266198
55telomere maintenance (GO:0000723)2.76126936
56dendritic cell chemotaxis (GO:0002407)2.75729754
57regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.75408049
58regulation of mitotic spindle checkpoint (GO:1903504)2.75408049
59protein K6-linked ubiquitination (GO:0085020)2.75209228
60telomere organization (GO:0032200)2.74815137
61prenylation (GO:0097354)2.74693904
62protein prenylation (GO:0018342)2.74693904
63DNA catabolic process, exonucleolytic (GO:0000738)2.73485310
64regulation of double-strand break repair via homologous recombination (GO:0010569)2.73358220
65DNA replication checkpoint (GO:0000076)2.73149331
66tryptophan catabolic process (GO:0006569)2.72681489
67indole-containing compound catabolic process (GO:0042436)2.72681489
68indolalkylamine catabolic process (GO:0046218)2.72681489
69kynurenine metabolic process (GO:0070189)2.72636931
70maturation of SSU-rRNA (GO:0030490)2.71608730
71viral mRNA export from host cell nucleus (GO:0046784)2.71588508
72telomere maintenance via telomere lengthening (GO:0010833)2.70144033
73adenosine metabolic process (GO:0046085)2.69507668
74somatic diversification of immunoglobulins (GO:0016445)2.68399756
75resolution of meiotic recombination intermediates (GO:0000712)2.67829646
76protein polyglutamylation (GO:0018095)2.67415956
77establishment of protein localization to mitochondrial membrane (GO:0090151)2.66189559
78epithelial cilium movement (GO:0003351)2.66063699
79DNA strand elongation (GO:0022616)2.64817977
80DNA strand elongation involved in DNA replication (GO:0006271)2.64009796
81translesion synthesis (GO:0019985)2.63007094
82energy coupled proton transport, down electrochemical gradient (GO:0015985)2.61561491
83ATP synthesis coupled proton transport (GO:0015986)2.61561491
84somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.61149161
85somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.61149161
86isotype switching (GO:0045190)2.61149161
87DNA replication-dependent nucleosome assembly (GO:0006335)2.60703691
88DNA replication-dependent nucleosome organization (GO:0034723)2.60703691
89ubiquinone metabolic process (GO:0006743)2.59597957
90regulation of nuclear cell cycle DNA replication (GO:0033262)2.59578733
91histone exchange (GO:0043486)2.59327475
92superoxide anion generation (GO:0042554)2.58893983
93deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.58779699
94DNA damage response, detection of DNA damage (GO:0042769)2.58182665
95pseudouridine synthesis (GO:0001522)2.57988850
96ubiquinone biosynthetic process (GO:0006744)2.57305037
97DNA synthesis involved in DNA repair (GO:0000731)2.57029882
98mismatch repair (GO:0006298)2.56688497
99rRNA methylation (GO:0031167)2.55917451
100cytidine metabolic process (GO:0046087)2.55892485
101cytidine catabolic process (GO:0006216)2.55892485
102cytidine deamination (GO:0009972)2.55892485
103somite development (GO:0061053)2.55821900
104positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54219938
105DNA replication initiation (GO:0006270)2.52891227
106epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.52692682
107GPI anchor metabolic process (GO:0006505)2.50598401
108dendritic cell migration (GO:0036336)2.49183278
109termination of RNA polymerase I transcription (GO:0006363)2.48824359
110rRNA modification (GO:0000154)2.47581361
111DNA integration (GO:0015074)2.46977200
112histone mRNA metabolic process (GO:0008334)2.44899474
113tryptophan metabolic process (GO:0006568)2.44012986
114intraciliary transport (GO:0042073)2.42924758
115ribosomal small subunit biogenesis (GO:0042274)2.42142844
1167-methylguanosine RNA capping (GO:0009452)2.41668737
117RNA capping (GO:0036260)2.41668737
118recombinational repair (GO:0000725)2.40245486
119nucleotide-excision repair, DNA gap filling (GO:0006297)2.39776619
120DNA strand renaturation (GO:0000733)2.38511080
121L-fucose catabolic process (GO:0042355)2.37726170
122fucose catabolic process (GO:0019317)2.37726170
123L-fucose metabolic process (GO:0042354)2.37726170
124GPI anchor biosynthetic process (GO:0006506)2.37580887
125termination of RNA polymerase III transcription (GO:0006386)2.37327600
126transcription elongation from RNA polymerase III promoter (GO:0006385)2.37327600
127pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.37067251
128DNA-dependent DNA replication (GO:0006261)2.36567637
129transcription from RNA polymerase I promoter (GO:0006360)2.36531109
130mannosylation (GO:0097502)2.34049798
1317-methylguanosine mRNA capping (GO:0006370)2.33962093
132response to interferon-beta (GO:0035456)2.33756448
133attachment of spindle microtubules to kinetochore (GO:0008608)2.33334108
134RNA methylation (GO:0001510)2.32639100
135preassembly of GPI anchor in ER membrane (GO:0016254)2.32579203
136transcription elongation from RNA polymerase I promoter (GO:0006362)2.32052889
137lymph node development (GO:0048535)2.31766086
138double-strand break repair via homologous recombination (GO:0000724)2.30853584
139DNA double-strand break processing (GO:0000729)2.30542974
140microtubule depolymerization (GO:0007019)2.30496412
141regulation of DNA endoreduplication (GO:0032875)2.30208777
142ribosomal large subunit biogenesis (GO:0042273)2.30197810
143maturation of 5.8S rRNA (GO:0000460)2.30023040
144interferon-gamma production (GO:0032609)2.29480491
145* tRNA processing (GO:0008033)2.28622967
146protein heterotetramerization (GO:0051290)2.28577666
147DNA recombination (GO:0006310)2.28572809
148* tRNA modification (GO:0006400)2.27577143
149positive regulation of gamma-delta T cell activation (GO:0046645)2.27469633
150RNA-dependent DNA replication (GO:0006278)2.27435627
151RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.27303495
152tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.27303495
153transcription-coupled nucleotide-excision repair (GO:0006283)2.26317220
154response to X-ray (GO:0010165)2.26169641
155histone H2A acetylation (GO:0043968)2.25177590
156regulation of RIG-I signaling pathway (GO:0039535)2.24804676
157DNA dealkylation (GO:0035510)2.23297456
158nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.23173251
159exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.22927284
160regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.20835905

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.05627928
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.73098982
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.27176987
4ZNF274_21170338_ChIP-Seq_K562_Hela3.17473967
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.14400176
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.04387428
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.03349261
8* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91421139
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.78999397
10VDR_22108803_ChIP-Seq_LS180_Human2.78571582
11* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.70641443
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.54985548
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49931137
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.46162916
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.43951895
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.43267812
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39388382
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.36605355
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.35254471
20* GBX2_23144817_ChIP-Seq_PC3_Human2.31146353
21IGF1R_20145208_ChIP-Seq_DFB_Human2.28801398
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19655557
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18988130
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18721494
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14662014
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.14446510
27NOTCH1_21737748_ChIP-Seq_TLL_Human2.12948929
28* ELK1_19687146_ChIP-ChIP_HELA_Human2.11767688
29* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08631527
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07715309
31* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04816247
32* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.03493789
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02700675
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02677980
35TAF15_26573619_Chip-Seq_HEK293_Human2.00205299
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93974440
37VDR_23849224_ChIP-Seq_CD4+_Human1.90466741
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.88337709
39IRF1_19129219_ChIP-ChIP_H3396_Human1.87160224
40SCL_19346495_ChIP-Seq_HPC-7_Human1.85241871
41* P300_19829295_ChIP-Seq_ESCs_Human1.84881630
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.83329497
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82952091
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.71749138
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70936258
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69193169
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67850944
48* FOXP3_21729870_ChIP-Seq_TREG_Human1.67789739
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67684194
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66709488
51EZH2_22144423_ChIP-Seq_EOC_Human1.63496564
52* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61754872
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.59731491
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58696102
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57353078
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56598192
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56132861
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.54576112
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53060541
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48464870
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47158379
62CBP_20019798_ChIP-Seq_JUKART_Human1.45911363
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45911363
64* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44750950
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.44594588
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42849933
67ER_23166858_ChIP-Seq_MCF-7_Human1.42782729
68* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42266103
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41385552
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.37009319
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36588886
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35507733
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34815226
74TP53_22573176_ChIP-Seq_HFKS_Human1.34405110
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34093586
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32018693
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31265085
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29812937
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29655201
80* EWS_26573619_Chip-Seq_HEK293_Human1.29431692
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.28324155
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26596336
83* FUS_26573619_Chip-Seq_HEK293_Human1.26221245
84* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25852514
85* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25274677
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24942038
87NANOG_19829295_ChIP-Seq_ESCs_Human1.24824991
88SOX2_19829295_ChIP-Seq_ESCs_Human1.24824991
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24805011
90DCP1A_22483619_ChIP-Seq_HELA_Human1.24689561
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24609774
92SPI1_23547873_ChIP-Seq_NB4_Human1.24600246
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24505166
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23268463
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21890890
96STAT3_23295773_ChIP-Seq_U87_Human1.21731562
97NMYC_18555785_Chip-Seq_ESCs_Mouse1.19983616
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19917230
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.19352156
100FOXM1_23109430_ChIP-Seq_U2OS_Human1.19259671
101SMAD4_21799915_ChIP-Seq_A2780_Human1.16963896
102FOXA1_25329375_ChIP-Seq_VCAP_Human1.16928916
103FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16928916
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16707201
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16707201
106P53_22387025_ChIP-Seq_ESCs_Mouse1.16429173
107EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16193175
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16014742
109* TCF4_23295773_ChIP-Seq_U87_Human1.15792525
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15312747
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.15018870
112P300_18555785_Chip-Seq_ESCs_Mouse1.14882414
113OCT4_18555785_Chip-Seq_ESCs_Mouse1.13336789
114E2F1_21310950_ChIP-Seq_MCF-7_Human1.11781525
115MYC_18940864_ChIP-ChIP_HL60_Human1.11191047
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.11151970
117E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09126396
118RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08416620
119AR_20517297_ChIP-Seq_VCAP_Human1.08234296
120CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08185917
121RNF2_27304074_Chip-Seq_NSC_Mouse1.07489718
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06679200
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05929948
124* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05472408
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05418223
126* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05368287
127* AR_25329375_ChIP-Seq_VCAP_Human1.04494378
128MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03629580
129* SMAD3_21741376_ChIP-Seq_EPCs_Human1.03204050
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03058185
131CRX_20693478_ChIP-Seq_RETINA_Mouse1.02803943
132ZFX_18555785_Chip-Seq_ESCs_Mouse1.02301043
133BCAT_22108803_ChIP-Seq_LS180_Human1.01869351
134YY1_21170310_ChIP-Seq_MESCs_Mouse1.00810038
135NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00670821
136FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00365629
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98911664
138KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98787843
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98309380
140* PIAS1_25552417_ChIP-Seq_VCAP_Human0.98087134
141CMYC_18555785_Chip-Seq_ESCs_Mouse0.98021573
142NCOR_22424771_ChIP-Seq_293T_Human0.97715297
143KLF4_18555785_Chip-Seq_ESCs_Mouse0.97126798
144SOX2_18555785_Chip-Seq_ESCs_Mouse0.96602733
145* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95614546
146PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95598465
147LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94749894
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94551969
149RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94498340
150TAL1_26923725_Chip-Seq_HPCs_Mouse0.94465217
151RUNX2_22187159_ChIP-Seq_PCA_Human0.92129213
152* TCF4_22108803_ChIP-Seq_LS180_Human0.91643079
153NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91163866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.10959087
2MP0008057_abnormal_DNA_replication3.05594058
3MP0003136_yellow_coat_color2.87060217
4MP0008058_abnormal_DNA_repair2.84705509
5MP0000566_synostosis2.84473626
6MP0005075_abnormal_melanosome_morpholog2.83435565
7MP0001835_abnormal_antigen_presentation2.72272389
8MP0001188_hyperpigmentation2.65940912
9MP0003763_abnormal_thymus_physiology2.64714788
10MP0000569_abnormal_digit_pigmentation2.62538135
11MP0004381_abnormal_hair_follicle2.62245369
12MP0001986_abnormal_taste_sensitivity2.59919356
13MP0010094_abnormal_chromosome_stability2.55672014
14MP0005174_abnormal_tail_pigmentation2.38470820
15MP0006072_abnormal_retinal_apoptosis2.38292171
16MP0005671_abnormal_response_to2.37845232
17MP0002396_abnormal_hematopoietic_system2.24392241
18MP0008007_abnormal_cellular_replicative2.17769468
19MP0000015_abnormal_ear_pigmentation2.17246053
20MP0003693_abnormal_embryo_hatching2.16975613
21MP0002009_preneoplasia2.14100314
22MP0009697_abnormal_copulation2.01975470
23MP0003646_muscle_fatigue2.01134576
24MP0003195_calcinosis1.99857794
25MP0002148_abnormal_hypersensitivity_rea1.93277341
26MP0005253_abnormal_eye_physiology1.91622609
27MP0002095_abnormal_skin_pigmentation1.88413839
28MP0002837_dystrophic_cardiac_calcinosis1.83389310
29MP0002277_abnormal_respiratory_mucosa1.82390738
30MP0009785_altered_susceptibility_to1.77708799
31MP0005551_abnormal_eye_electrophysiolog1.76616226
32MP0000490_abnormal_crypts_of1.74765900
33MP0000372_irregular_coat_pigmentation1.66431293
34MP0003786_premature_aging1.66372726
35MP0002234_abnormal_pharynx_morphology1.66211456
36MP0002132_abnormal_respiratory_system1.66094729
37MP0004145_abnormal_muscle_electrophysio1.65088998
38MP0000685_abnormal_immune_system1.64782936
39MP0008872_abnormal_physiological_respon1.63707020
40MP0005171_absent_coat_pigmentation1.62557148
41MP0003077_abnormal_cell_cycle1.62350175
42MP0003111_abnormal_nucleus_morphology1.60618774
43MP0003567_abnormal_fetal_cardiomyocyte1.60590766
44MP0008995_early_reproductive_senescence1.60200904
45MP0008877_abnormal_DNA_methylation1.57239980
46MP0001800_abnormal_humoral_immune1.56808016
47MP0001529_abnormal_vocalization1.55670044
48MP0003724_increased_susceptibility_to1.51316781
49MP0009379_abnormal_foot_pigmentation1.51118202
50MP0003880_abnormal_central_pattern1.50770828
51MP0000631_abnormal_neuroendocrine_gland1.50059353
52MP0002751_abnormal_autonomic_nervous1.48712924
53MP0003121_genomic_imprinting1.48113292
54MP0004142_abnormal_muscle_tone1.47726994
55MP0006276_abnormal_autonomic_nervous1.46219089
56MP0002452_abnormal_antigen_presenting1.45700927
57MP0002420_abnormal_adaptive_immunity1.44639471
58MP0002723_abnormal_immune_serum1.43672867
59MP0005000_abnormal_immune_tolerance1.43326922
60MP0001819_abnormal_immune_cell1.42280823
61MP0002398_abnormal_bone_marrow1.38010049
62MP0005025_abnormal_response_to1.35190313
63MP0002166_altered_tumor_susceptibility1.34063968
64MP0002102_abnormal_ear_morphology1.33196627
65MP0001873_stomach_inflammation1.32310545
66MP0002419_abnormal_innate_immunity1.30652264
67MP0005387_immune_system_phenotype1.29577145
68MP0001790_abnormal_immune_system1.29577145
69MP0001853_heart_inflammation1.27773717
70MP0001293_anophthalmia1.26892456
71MP0005409_darkened_coat_color1.26817713
72MP0004133_heterotaxia1.26167835
73MP0002736_abnormal_nociception_after1.26037989
74MP0005084_abnormal_gallbladder_morpholo1.24558854
75MP0009333_abnormal_splenocyte_physiolog1.23979914
76MP0002006_tumorigenesis1.23716436
77MP0004147_increased_porphyrin_level1.21596491
78MP0000689_abnormal_spleen_morphology1.21061580
79MP0009046_muscle_twitch1.20779807
80MP0002938_white_spotting1.18642490
81MP0000716_abnormal_immune_system1.18097301
82MP0000427_abnormal_hair_cycle1.16432061
83MP0003941_abnormal_skin_development1.15628521
84MP0002163_abnormal_gland_morphology1.13044445
85MP0001968_abnormal_touch/_nociception1.12936381
86MP0000703_abnormal_thymus_morphology1.12580925
87MP0003011_delayed_dark_adaptation1.12470693
88MP0002405_respiratory_system_inflammati1.12286303
89MP0008789_abnormal_olfactory_epithelium1.11675033
90MP0002160_abnormal_reproductive_system1.10879747
91MP0004808_abnormal_hematopoietic_stem1.10422938
92MP0001984_abnormal_olfaction1.09780652
93MP0004782_abnormal_surfactant_physiolog1.09677605
94MP0008875_abnormal_xenobiotic_pharmacok1.09575848
95MP0001545_abnormal_hematopoietic_system1.09133520
96MP0005397_hematopoietic_system_phenotyp1.09133520
97MP0002653_abnormal_ependyma_morphology1.08441199
98MP0003937_abnormal_limbs/digits/tail_de1.08028207
99MP0002722_abnormal_immune_system1.07799475
100MP0003890_abnormal_embryonic-extraembry1.05287335
101MP0002429_abnormal_blood_cell1.03955221
102MP0000383_abnormal_hair_follicle1.03771703
103MP0008260_abnormal_autophagy1.02704793
104MP0005389_reproductive_system_phenotype1.02298015
105MP0000653_abnormal_sex_gland1.01359900
106MP0002638_abnormal_pupillary_reflex0.99490680
107MP0003718_maternal_effect0.99191072
108MP0005464_abnormal_platelet_physiology0.99109552
109MP0005410_abnormal_fertilization0.98838370
110MP0003943_abnormal_hepatobiliary_system0.98591080
111MP0002075_abnormal_coat/hair_pigmentati0.98413759
112MP0001186_pigmentation_phenotype0.97481836
113MP0005646_abnormal_pituitary_gland0.96814862
114MP0005379_endocrine/exocrine_gland_phen0.96057630
115MP0000647_abnormal_sebaceous_gland0.95411560
116MP0010155_abnormal_intestine_physiology0.95291540
117MP0002210_abnormal_sex_determination0.95039849
118MP0006035_abnormal_mitochondrial_morpho0.94982580
119MP0001119_abnormal_female_reproductive0.93663482
120MP0001485_abnormal_pinna_reflex0.93638938
121MP0006036_abnormal_mitochondrial_physio0.92459360
122MP0003122_maternal_imprinting0.92347545
123MP0003436_decreased_susceptibility_to0.91817015
124MP0003186_abnormal_redox_activity0.90734573
125MP0004043_abnormal_pH_regulation0.90026504
126MP0008775_abnormal_heart_ventricle0.89423266
127MP0002735_abnormal_chemical_nociception0.89318517
128MP0001145_abnormal_male_reproductive0.89280894
129MP0005391_vision/eye_phenotype0.88690891
130MP0001929_abnormal_gametogenesis0.88526776
131MP0002138_abnormal_hepatobiliary_system0.88368567
132MP0000613_abnormal_salivary_gland0.88006616
133MP0002876_abnormal_thyroid_physiology0.86308716
134MP0005195_abnormal_posterior_eye0.85036331
135MP0010386_abnormal_urinary_bladder0.84728310
136MP0009745_abnormal_behavioral_response0.83902333
137MP0003698_abnormal_male_reproductive0.83689116
138MP0005408_hypopigmentation0.82787336
139MP0002557_abnormal_social/conspecific_i0.81270063
140MP0004215_abnormal_myocardial_fiber0.80391782
141MP0008932_abnormal_embryonic_tissue0.79297848
142MP0000049_abnormal_middle_ear0.79209467
143MP0001919_abnormal_reproductive_system0.79043388
144MP0001346_abnormal_lacrimal_gland0.78599016
145MP0002254_reproductive_system_inflammat0.78339705
146MP0004957_abnormal_blastocyst_morpholog0.77968535
147MP0005645_abnormal_hypothalamus_physiol0.77589148
148MP0001286_abnormal_eye_development0.76606467
149MP0002272_abnormal_nervous_system0.76028326
150MP0004134_abnormal_chest_morphology0.75589213
151MP0000465_gastrointestinal_hemorrhage0.74995864
152MP0005187_abnormal_penis_morphology0.74854326
153MP0005394_taste/olfaction_phenotype0.74577715
154MP0005499_abnormal_olfactory_system0.74577715
155MP0002928_abnormal_bile_duct0.72592322
156MP0005266_abnormal_metabolism0.71983808
157MP0003787_abnormal_imprinting0.70925223
158MP0001905_abnormal_dopamine_level0.70672091
159MP0003137_abnormal_impulse_conducting0.70476060
160MP0001764_abnormal_homeostasis0.69874301
161MP0001845_abnormal_inflammatory_respons0.69339783

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.77487352
2Chromsome breakage (HP:0040012)4.67462261
3Molar tooth sign on MRI (HP:0002419)3.43806470
4Abnormality of midbrain morphology (HP:0002418)3.43806470
5Type I transferrin isoform profile (HP:0003642)3.31967694
6Abnormality of the renal collecting system (HP:0004742)3.29649460
7Nephronophthisis (HP:0000090)3.07632970
8Reticulocytopenia (HP:0001896)3.06085039
9Medial flaring of the eyebrow (HP:0010747)3.04597512
10Duplicated collecting system (HP:0000081)3.03617839
11Prostate neoplasm (HP:0100787)3.02387857
12Abnormality of the preputium (HP:0100587)2.91203750
13Type 2 muscle fiber atrophy (HP:0003554)2.87640304
14True hermaphroditism (HP:0010459)2.85702359
15Colon cancer (HP:0003003)2.79992364
16Acute necrotizing encephalopathy (HP:0006965)2.79775806
17Abnormality of chromosome stability (HP:0003220)2.75451590
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.74830138
19Abnormality of the renal medulla (HP:0100957)2.71736844
20Acute encephalopathy (HP:0006846)2.69158880
21Meckel diverticulum (HP:0002245)2.68122017
22Clubbing of toes (HP:0100760)2.67407096
23Abnormality of the renal cortex (HP:0011035)2.64084506
24Reduced antithrombin III activity (HP:0001976)2.63922146
25Methylmalonic acidemia (HP:0002912)2.62202207
26Abnormality of the ileum (HP:0001549)2.59062365
27Abnormality of the prostate (HP:0008775)2.58557571
28Congenital stationary night blindness (HP:0007642)2.58415388
29Chronic hepatic failure (HP:0100626)2.58356008
30Patchy hypopigmentation of hair (HP:0011365)2.57278061
31Abnormality of DNA repair (HP:0003254)2.53538569
32Mitochondrial inheritance (HP:0001427)2.51328519
33Increased CSF lactate (HP:0002490)2.50936416
34Aplastic anemia (HP:0001915)2.49800598
35Progressive macrocephaly (HP:0004481)2.49243343
36White forelock (HP:0002211)2.48410704
37Dry hair (HP:0011359)2.47527359
3811 pairs of ribs (HP:0000878)2.46685706
39Optic neuritis (HP:0100653)2.45605761
40Retrobulbar optic neuritis (HP:0100654)2.45605761
41IgM deficiency (HP:0002850)2.45424269
42Abnormal mitochondria in muscle tissue (HP:0008316)2.43998587
43Abnormality of the columella (HP:0009929)2.42355175
44Methylmalonic aciduria (HP:0012120)2.41950918
45Pancreatic fibrosis (HP:0100732)2.41653715
46Abnormality of the labia minora (HP:0012880)2.41186155
47Microvesicular hepatic steatosis (HP:0001414)2.39501544
48Abnormal number of erythroid precursors (HP:0012131)2.39153423
49Tubulointerstitial nephritis (HP:0001970)2.38484154
503-Methylglutaconic aciduria (HP:0003535)2.37489652
51Intestinal atresia (HP:0011100)2.37335126
52Supernumerary spleens (HP:0009799)2.35706211
53Muscle fiber atrophy (HP:0100295)2.34763675
54Pancreatic cysts (HP:0001737)2.33896725
55Hyperventilation (HP:0002883)2.31589879
56Abnormal protein glycosylation (HP:0012346)2.29368889
57Abnormal glycosylation (HP:0012345)2.29368889
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29368889
59Abnormal protein N-linked glycosylation (HP:0012347)2.29368889
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.27646355
61Birth length less than 3rd percentile (HP:0003561)2.27559491
62Myositis (HP:0100614)2.27072272
63Abolished electroretinogram (ERG) (HP:0000550)2.25775876
64Dynein arm defect of respiratory motile cilia (HP:0012255)2.25522209
65Absent/shortened dynein arms (HP:0200106)2.25522209
66Myelodysplasia (HP:0002863)2.22679340
67Ectopic kidney (HP:0000086)2.20624150
68Aplasia/Hypoplasia of the tongue (HP:0010295)2.19836108
69Asplenia (HP:0001746)2.18946519
70Cystic liver disease (HP:0006706)2.17810838
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16627736
72Hepatocellular necrosis (HP:0001404)2.16310260
73Duodenal stenosis (HP:0100867)2.13978871
74Small intestinal stenosis (HP:0012848)2.13978871
75Type II lissencephaly (HP:0007260)2.12794835
76Abnormal hair whorl (HP:0010721)2.10765570
77Hypergonadotropic hypogonadism (HP:0000815)2.10705003
78Hypothermia (HP:0002045)2.10373213
79Congenital primary aphakia (HP:0007707)2.10371078
80Abnormality of cells of the erythroid lineage (HP:0012130)2.09763276
81Abnormality of secondary sexual hair (HP:0009888)2.06185698
82Abnormality of the axillary hair (HP:0100134)2.06185698
83Ependymoma (HP:0002888)2.05938725
84Bone marrow hypocellularity (HP:0005528)2.05812702
85Lipid accumulation in hepatocytes (HP:0006561)2.05714725
86Renal cortical cysts (HP:0000803)2.05352465
87Gait imbalance (HP:0002141)2.04543661
88Recurrent abscess formation (HP:0002722)2.03403413
89Hepatic necrosis (HP:0002605)2.02395955
90Gaze-evoked nystagmus (HP:0000640)2.02300176
91Short tibia (HP:0005736)2.01978942
92Abnormality of alanine metabolism (HP:0010916)2.01654591
93Hyperalaninemia (HP:0003348)2.01654591
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01654591
95Thyroiditis (HP:0100646)2.01334497
96Sclerocornea (HP:0000647)2.00677478
97Volvulus (HP:0002580)1.99725932
98Duplication of thumb phalanx (HP:0009942)1.98139185
99Glioma (HP:0009733)1.97396696
100Male pseudohermaphroditism (HP:0000037)1.97268933
101Aplasia cutis congenita (HP:0001057)1.95117485
102Abnormal lung lobation (HP:0002101)1.94889801
103Pancytopenia (HP:0001876)1.94667485
104Bile duct proliferation (HP:0001408)1.94341227
105Abnormal biliary tract physiology (HP:0012439)1.94341227
106Aplasia/Hypoplasia of the spleen (HP:0010451)1.92931006
107Increased serum lactate (HP:0002151)1.92650306
108Anencephaly (HP:0002323)1.92033723
109Genital tract atresia (HP:0001827)1.91760729
110Attenuation of retinal blood vessels (HP:0007843)1.91759553
111Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91480600
112Hyperglycinemia (HP:0002154)1.91291355
113Lip pit (HP:0100267)1.91067019
114Pendular nystagmus (HP:0012043)1.89800483
115Thrombocytosis (HP:0001894)1.89273508
116Nephrogenic diabetes insipidus (HP:0009806)1.88692482
117Cerebral edema (HP:0002181)1.88561501
118Chronic diarrhea (HP:0002028)1.87884430
119IgG deficiency (HP:0004315)1.87655020
120Abnormality of the pons (HP:0007361)1.85352138
121Nephroblastoma (Wilms tumor) (HP:0002667)1.84786401
122Premature graying of hair (HP:0002216)1.84574940
123Abnormal respiratory motile cilium morphology (HP:0005938)1.84083016
124Abnormal respiratory epithelium morphology (HP:0012253)1.84083016
125Aplasia/hypoplasia of the uterus (HP:0008684)1.84077468
126Vaginal atresia (HP:0000148)1.83127097
127Orchitis (HP:0100796)1.82531235
128Congenital hepatic fibrosis (HP:0002612)1.82046765
129Hypoplasia of the pons (HP:0012110)1.81205271
130Sloping forehead (HP:0000340)1.81083422
131Congenital, generalized hypertrichosis (HP:0004540)1.80689297
132Amaurosis fugax (HP:0100576)1.80503591
133Prolonged bleeding time (HP:0003010)1.80481803
134Nonprogressive disorder (HP:0003680)1.78775364
135Triphalangeal thumb (HP:0001199)1.78203415
136Abnormality of male internal genitalia (HP:0000022)1.78165406
137Pallor (HP:0000980)1.77418453
138Preaxial hand polydactyly (HP:0001177)1.77394178
139Absent speech (HP:0001344)1.77228329
140Optic nerve hypoplasia (HP:0000609)1.76657565
141Patellar aplasia (HP:0006443)1.76302154
142Abnormality of the astrocytes (HP:0100707)1.75629109
143Astrocytoma (HP:0009592)1.75629109
144Lymphoma (HP:0002665)1.75587743
145Abnormality of the duodenum (HP:0002246)1.75153132
146Recurrent bacterial skin infections (HP:0005406)1.74782181
147Mediastinal lymphadenopathy (HP:0100721)1.74676589
148Septo-optic dysplasia (HP:0100842)1.74431517
149Lactic acidosis (HP:0003128)1.73511761
150Postaxial foot polydactyly (HP:0001830)1.73481812
151Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73093887
152Aplasia/Hypoplasia of the patella (HP:0006498)1.73062246
153Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72409585
154Embryonal renal neoplasm (HP:0011794)1.72117082
155Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71595145
156Abnormal spermatogenesis (HP:0008669)1.71509133
157Dandy-Walker malformation (HP:0001305)1.71181621
158Keratoconjunctivitis (HP:0001096)1.70430476
159Anhidrosis (HP:0000970)1.70388305
160Petechiae (HP:0000967)1.69834139
161Postaxial hand polydactyly (HP:0001162)1.69580834
162Cerebellar dysplasia (HP:0007033)1.69522780
163Lissencephaly (HP:0001339)1.68598565
164Optic disc pallor (HP:0000543)1.68285210
165Recurrent pneumonia (HP:0006532)1.68096673
166Furrowed tongue (HP:0000221)1.67646466
167Fair hair (HP:0002286)1.66874687
168Hypoplasia of the thymus (HP:0000778)1.66305086
169Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65585343
170Tubular atrophy (HP:0000092)1.65582661
171Thyroid-stimulating hormone excess (HP:0002925)1.64740061
172Weak cry (HP:0001612)1.63416303
173Increased hepatocellular lipid droplets (HP:0006565)1.63298174
174Absent rod-and cone-mediated responses on ERG (HP:0007688)1.62666892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.93346225
2STK163.22692290
3TXK3.14389977
4MAP4K23.06181651
5IRAK32.85885409
6MUSK2.85053189
7ZAK2.61085848
8SRPK12.61068387
9VRK22.50603018
10MAP3K142.45090437
11IRAK42.35933982
12TRIM282.34529763
13WNK32.32370531
14MKNK12.26535801
15CASK2.23113777
16MKNK22.17671758
17TNIK2.12423266
18PLK42.11257104
19TEC1.91133504
20VRK11.78031993
21EIF2AK21.69317201
22BMPR1B1.67956301
23BCKDK1.63173580
24MAP3K41.59267479
25MST41.56221886
26NUAK11.49883248
27BUB11.47742322
28NEK61.45711606
29EIF2AK11.43803845
30MAPK131.42616296
31YES11.41749774
32CDK81.41561724
33BCR1.39844453
34KIT1.38513401
35IKBKB1.30761549
36JAK31.30672967
37NLK1.29491795
38MAP4K11.27935026
39ADRBK21.23123289
40EIF2AK31.19491679
41INSRR1.18318156
42IKBKE1.15733780
43CDC71.12377736
44PLK21.11441968
45CLK11.10910810
46CSNK1G11.10560484
47WEE11.10332549
48CSNK1G21.06868152
49NME21.06799154
50BTK1.06062374
51BMPR21.05536397
52CSNK1G31.05282181
53ERBB31.04696448
54GRK11.01347818
55ATR1.01337393
56DYRK20.98467700
57OXSR10.97209104
58TLK10.97073385
59NEK10.96538673
60CDK30.95676761
61TIE10.95240092
62PIM10.95135896
63ACVR1B0.95125034
64TRPM70.94735619
65PIK3CG0.94280367
66IRAK10.93738493
67TAF10.91677225
68BRSK20.91567428
69CSNK1A1L0.90459330
70DYRK30.87542879
71SIK30.86506882
72CHUK0.86086394
73MAP2K70.85510472
74BRD40.85302666
75NME10.84405064
76PIM20.81203846
77GRK70.79353856
78RPS6KA50.78249275
79STK240.76702613
80NEK90.75905373
81STK390.75252682
82ZAP700.74494271
83PRKCE0.71439335
84AURKB0.70756430
85ITK0.70089024
86LYN0.68762364
87PLK10.68612401
88PAK30.68571705
89CDK70.68479659
90PNCK0.68465947
91IRAK20.67961641
92EPHA30.67499975
93WNK40.64129861
94PRPF4B0.63823200
95LCK0.62203610
96MAPKAPK50.61863484
97TAOK30.60054920
98PINK10.58722517
99AKT30.57563508
100MAPKAPK30.56214194
101MAP2K60.55930827
102PRKCG0.55297798
103SGK20.55285766
104TTK0.55283658
105STK40.55012704
106CHEK20.54566650
107OBSCN0.54213778
108SYK0.54167605
109TGFBR10.53943651
110CHEK10.53876302
111PBK0.51773719
112CCNB10.51707572
113PASK0.51321052
114CSF1R0.51169213
115ADRBK10.50868266
116ATM0.50379670
117PLK30.49163204
118STK30.46787881
119EPHA40.46075037
120FGFR20.45289261
121CSNK2A10.45158821
122TYK20.43042006
123NEK20.42717091
124PKN10.42646057
125PHKG20.42528188
126PHKG10.42528188
127MAPK150.41934091
128BLK0.41798893
129FER0.41653586
130FLT30.41626327
131MYLK0.40835456
132MELK0.39943892
133RPS6KA60.39152336
134ERBB20.38964327
135PRKCQ0.37811083
136CAMKK20.37364007
137TSSK60.37248529
138CSNK1A10.36697746
139PIK3CA0.36468832
140MAP3K120.35482381
141MAP2K30.35004256
142RPS6KA40.34696556
143STK38L0.33716279
144PRKACA0.32591214
145CSNK2A20.31440121
146PRKAA10.28822266

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.42610973
2DNA replication_Homo sapiens_hsa030303.40141320
3Homologous recombination_Homo sapiens_hsa034403.38911798
4Mismatch repair_Homo sapiens_hsa034303.05985101
5Non-homologous end-joining_Homo sapiens_hsa034502.88992998
6Ribosome_Homo sapiens_hsa030102.61926265
7Base excision repair_Homo sapiens_hsa034102.59677853
8RNA polymerase_Homo sapiens_hsa030202.53714658
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34818873
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.33464600
11Nucleotide excision repair_Homo sapiens_hsa034202.20084317
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17983068
13Propanoate metabolism_Homo sapiens_hsa006402.10129445
14Basal transcription factors_Homo sapiens_hsa030222.05671987
15Protein export_Homo sapiens_hsa030601.99961447
16Pyrimidine metabolism_Homo sapiens_hsa002401.97411817
17Proteasome_Homo sapiens_hsa030501.91484115
18Primary immunodeficiency_Homo sapiens_hsa053401.85169019
19Spliceosome_Homo sapiens_hsa030401.77032252
20Allograft rejection_Homo sapiens_hsa053301.74462146
21RNA degradation_Homo sapiens_hsa030181.73508083
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.71202802
23Butanoate metabolism_Homo sapiens_hsa006501.69426252
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65222712
25Cell cycle_Homo sapiens_hsa041101.65042291
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.64349549
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59557911
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59415254
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58716585
30Graft-versus-host disease_Homo sapiens_hsa053321.56940205
31Selenocompound metabolism_Homo sapiens_hsa004501.55971525
32Nitrogen metabolism_Homo sapiens_hsa009101.53149083
33One carbon pool by folate_Homo sapiens_hsa006701.51231309
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48920332
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.47617059
36Purine metabolism_Homo sapiens_hsa002301.42660588
37Measles_Homo sapiens_hsa051621.40350673
38Caffeine metabolism_Homo sapiens_hsa002321.38690449
39Hematopoietic cell lineage_Homo sapiens_hsa046401.31753896
40Arachidonic acid metabolism_Homo sapiens_hsa005901.31641819
41Autoimmune thyroid disease_Homo sapiens_hsa053201.27985279
42Herpes simplex infection_Homo sapiens_hsa051681.27124718
43Peroxisome_Homo sapiens_hsa041461.26421592
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22361524
45Alzheimers disease_Homo sapiens_hsa050101.21755305
46Tryptophan metabolism_Homo sapiens_hsa003801.21536749
47p53 signaling pathway_Homo sapiens_hsa041151.21019751
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20557080
49Steroid biosynthesis_Homo sapiens_hsa001001.16028909
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10867811
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07955046
52RNA transport_Homo sapiens_hsa030131.07665858
53Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05187028
54Systemic lupus erythematosus_Homo sapiens_hsa053221.04993355
55Antigen processing and presentation_Homo sapiens_hsa046120.99103990
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99021163
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98723292
58Nicotine addiction_Homo sapiens_hsa050330.91656488
59Asthma_Homo sapiens_hsa053100.91257662
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91049518
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.89946358
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89142334
63Other glycan degradation_Homo sapiens_hsa005110.88515639
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88482006
65Olfactory transduction_Homo sapiens_hsa047400.86957480
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.86757639
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.85937372
68Taste transduction_Homo sapiens_hsa047420.83322027
69Leishmaniasis_Homo sapiens_hsa051400.81773054
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80153087
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79644616
72Sphingolipid metabolism_Homo sapiens_hsa006000.79594790
73Chemical carcinogenesis_Homo sapiens_hsa052040.75010419
74Epstein-Barr virus infection_Homo sapiens_hsa051690.73644239
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72813960
76Linoleic acid metabolism_Homo sapiens_hsa005910.72601559
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.71961870
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71233474
79Cardiac muscle contraction_Homo sapiens_hsa042600.70148797
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69769697
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69661475
82Retinol metabolism_Homo sapiens_hsa008300.69572282
83mRNA surveillance pathway_Homo sapiens_hsa030150.69502449
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69347930
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69109685
86Influenza A_Homo sapiens_hsa051640.65905832
87Malaria_Homo sapiens_hsa051440.64848207
88Rheumatoid arthritis_Homo sapiens_hsa053230.60231271
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59224299
90Alcoholism_Homo sapiens_hsa050340.58602103
91Oxidative phosphorylation_Homo sapiens_hsa001900.58548327
92Huntingtons disease_Homo sapiens_hsa050160.58246913
93Ether lipid metabolism_Homo sapiens_hsa005650.56575731
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55228844
95Fatty acid metabolism_Homo sapiens_hsa012120.55042374
96Legionellosis_Homo sapiens_hsa051340.54007034
97T cell receptor signaling pathway_Homo sapiens_hsa046600.51242347
98Viral carcinogenesis_Homo sapiens_hsa052030.50911564
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50793582
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49420631
101Apoptosis_Homo sapiens_hsa042100.48792627
102beta-Alanine metabolism_Homo sapiens_hsa004100.47312557
103Parkinsons disease_Homo sapiens_hsa050120.47192505
104Regulation of autophagy_Homo sapiens_hsa041400.46826264
105Type I diabetes mellitus_Homo sapiens_hsa049400.46495475
106Vitamin digestion and absorption_Homo sapiens_hsa049770.45554467
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44984552
108Oocyte meiosis_Homo sapiens_hsa041140.43790314
109Pyruvate metabolism_Homo sapiens_hsa006200.43693375
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43285742
111ABC transporters_Homo sapiens_hsa020100.42997062
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.41618479
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40776304
114HTLV-I infection_Homo sapiens_hsa051660.40511269
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.40136216
116Fatty acid degradation_Homo sapiens_hsa000710.39204016
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38885576
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37946850
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37759882
120Folate biosynthesis_Homo sapiens_hsa007900.35906942
121Sulfur metabolism_Homo sapiens_hsa009200.35680840
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34584928
123Fatty acid elongation_Homo sapiens_hsa000620.34385688
124Osteoclast differentiation_Homo sapiens_hsa043800.33987396
125Hepatitis B_Homo sapiens_hsa051610.33925225
126Phototransduction_Homo sapiens_hsa047440.33597564
127TNF signaling pathway_Homo sapiens_hsa046680.33501668
128Metabolic pathways_Homo sapiens_hsa011000.33098709
129Toxoplasmosis_Homo sapiens_hsa051450.33047685
130Notch signaling pathway_Homo sapiens_hsa043300.32660805
131Fat digestion and absorption_Homo sapiens_hsa049750.32212281
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31820948
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31420794
134Morphine addiction_Homo sapiens_hsa050320.30128651
135Serotonergic synapse_Homo sapiens_hsa047260.28641076
136N-Glycan biosynthesis_Homo sapiens_hsa005100.27647985
137B cell receptor signaling pathway_Homo sapiens_hsa046620.26789931
138Small cell lung cancer_Homo sapiens_hsa052220.23424517
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22360862
140Glutathione metabolism_Homo sapiens_hsa004800.22131147
141Pertussis_Homo sapiens_hsa051330.21571229
142African trypanosomiasis_Homo sapiens_hsa051430.20835272
143Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19797308

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