CDKL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfation (GO:0051923)6.20741466
2behavioral response to nicotine (GO:0035095)5.44826284
3drug transmembrane transport (GO:0006855)5.40194766
4aminoglycoside antibiotic metabolic process (GO:0030647)5.24783841
5lysine catabolic process (GO:0006554)5.09491082
6lysine metabolic process (GO:0006553)5.09491082
7excretion (GO:0007588)4.78979946
8organic cation transport (GO:0015695)4.74467542
9phosphate ion transport (GO:0006817)4.73849702
10response to mercury ion (GO:0046689)4.72632096
11cellular response to ATP (GO:0071318)4.72355955
12urate metabolic process (GO:0046415)4.67340797
13positive regulation of cAMP-mediated signaling (GO:0043950)4.56893518
14tryptophan catabolic process (GO:0006569)4.52464860
15indole-containing compound catabolic process (GO:0042436)4.52464860
16indolalkylamine catabolic process (GO:0046218)4.52464860
17indolalkylamine metabolic process (GO:0006586)4.48969444
18negative regulation of systemic arterial blood pressure (GO:0003085)4.45752920
19kynurenine metabolic process (GO:0070189)4.43663390
20metanephric nephron tubule development (GO:0072234)4.40292558
21metanephric tubule development (GO:0072170)4.40292558
22tryptophan metabolic process (GO:0006568)4.30530737
23drug transport (GO:0015893)4.23058742
24renal absorption (GO:0070293)4.19818594
25DNA deamination (GO:0045006)4.14233324
26polyol transport (GO:0015791)4.07607620
27metanephric nephron epithelium development (GO:0072243)4.02053848
28gamma-aminobutyric acid transport (GO:0015812)4.00814756
29aspartate family amino acid catabolic process (GO:0009068)3.99782646
30quaternary ammonium group transport (GO:0015697)3.97785100
31cell proliferation in forebrain (GO:0021846)3.86827665
32response to parathyroid hormone (GO:0071107)3.86804780
33water-soluble vitamin biosynthetic process (GO:0042364)3.85829867
34purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.83540538
353-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.83540538
36regulation of glomerulus development (GO:0090192)3.79850602
37flavonoid metabolic process (GO:0009812)3.78059613
38tricarboxylic acid cycle (GO:0006099)3.72763317
39positive regulation of fatty acid oxidation (GO:0046321)3.72340561
40tricarboxylic acid metabolic process (GO:0072350)3.70406241
41NADH metabolic process (GO:0006734)3.65910801
42membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.63885990
43metanephric epithelium development (GO:0072207)3.63070639
44negative regulation of mast cell activation (GO:0033004)3.62210417
45cellular potassium ion homeostasis (GO:0030007)3.59986910
46regulation of cell proliferation involved in kidney development (GO:1901722)3.58521425
47regulation of hippo signaling (GO:0035330)3.54729890
48indole-containing compound metabolic process (GO:0042430)3.53439142
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.49641896
50serotonin metabolic process (GO:0042428)3.49531088
51positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.49225217
52ATP hydrolysis coupled proton transport (GO:0015991)3.48027298
53energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.48027298
54amine catabolic process (GO:0009310)3.45481845
55cellular biogenic amine catabolic process (GO:0042402)3.45481845
56phosphate ion transmembrane transport (GO:0035435)3.45418990
57negative regulation of appetite (GO:0032099)3.44816625
58negative regulation of response to food (GO:0032096)3.44816625
59nonribosomal peptide biosynthetic process (GO:0019184)3.42897119
60succinate metabolic process (GO:0006105)3.38142405
61amino-acid betaine transport (GO:0015838)3.36883707
62carnitine transport (GO:0015879)3.36883707
63regulation of phospholipid biosynthetic process (GO:0071071)3.34910310
64positive regulation of cardiac muscle cell differentiation (GO:2000727)3.34407654
65nephron tubule morphogenesis (GO:0072078)3.33586096
66nephron epithelium morphogenesis (GO:0072088)3.33586096
67mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.32819780
68short-chain fatty acid metabolic process (GO:0046459)3.32232217
69sphingosine metabolic process (GO:0006670)3.31813723
70negative regulation of transcription regulatory region DNA binding (GO:2000678)3.31078316
71cytidine metabolic process (GO:0046087)3.30666275
72cytidine catabolic process (GO:0006216)3.30666275
73cytidine deamination (GO:0009972)3.30666275
74sphingoid metabolic process (GO:0046519)3.29131595
75negative regulation of platelet activation (GO:0010544)3.26667822
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.25109029
77glutathione biosynthetic process (GO:0006750)3.21657331
78membrane repolarization during action potential (GO:0086011)3.21265984
79primary amino compound metabolic process (GO:1901160)3.19687461
80sodium ion export (GO:0071436)3.17403709
81diol metabolic process (GO:0034311)3.16545264
82aromatic amino acid family catabolic process (GO:0009074)3.11929485
83nephron tubule development (GO:0072080)3.08810563
84DNA methylation involved in gamete generation (GO:0043046)3.06440617
85positive regulation of fatty acid beta-oxidation (GO:0032000)3.04750902
86synaptic vesicle exocytosis (GO:0016079)3.03896056
87ATP synthesis coupled proton transport (GO:0015986)3.02313910
88energy coupled proton transport, down electrochemical gradient (GO:0015985)3.02313910
89regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.01225855
90regulation of collateral sprouting (GO:0048670)3.00632609
91protein polyglutamylation (GO:0018095)3.00132916
92peristalsis (GO:0030432)3.00033471
93cellular ketone body metabolic process (GO:0046950)2.97298915
94cell communication by electrical coupling (GO:0010644)2.96444852
95respiratory electron transport chain (GO:0022904)2.96041803
962-oxoglutarate metabolic process (GO:0006103)2.93747547
97lactate metabolic process (GO:0006089)2.93364086
98electron transport chain (GO:0022900)2.92911264
99dopamine transport (GO:0015872)2.92173357
100regulation of posttranscriptional gene silencing (GO:0060147)2.92163584
101regulation of gene silencing by miRNA (GO:0060964)2.92163584
102regulation of gene silencing by RNA (GO:0060966)2.92163584
103regulation of sequestering of triglyceride (GO:0010889)2.91733269
104regulation of DNA endoreduplication (GO:0032875)2.91009653
105piRNA metabolic process (GO:0034587)2.89670811
106glycoside metabolic process (GO:0016137)2.89307104
107epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86800413
108renal tubule morphogenesis (GO:0061333)2.86598843
109negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.86254044
110L-fucose catabolic process (GO:0042355)2.86133709
111fucose catabolic process (GO:0019317)2.86133709
112L-fucose metabolic process (GO:0042354)2.86133709
113aromatic amino acid family metabolic process (GO:0009072)2.86017541
114regulation of neurotransmitter uptake (GO:0051580)2.85736955
115sodium ion transport (GO:0006814)2.84381388
116dorsal/ventral axis specification (GO:0009950)2.83063006
117detection of calcium ion (GO:0005513)2.82924163
118detection of light stimulus involved in visual perception (GO:0050908)2.82878670
119detection of light stimulus involved in sensory perception (GO:0050962)2.82878670
120renal tubule development (GO:0061326)2.82249445
121protein neddylation (GO:0045116)2.80895716
122actin filament depolymerization (GO:0030042)2.79543203
123tachykinin receptor signaling pathway (GO:0007217)2.79427922
124transferrin transport (GO:0033572)2.79213787
125reflex (GO:0060004)2.78508634
126regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78464972
127adaptation of signaling pathway (GO:0023058)2.76347382
128regulation of synaptic vesicle exocytosis (GO:2000300)2.76084675
129regulation of rhodopsin mediated signaling pathway (GO:0022400)2.76057307
130collecting duct development (GO:0072044)2.75700437
131water transport (GO:0006833)2.74715744
132sulfate transmembrane transport (GO:1902358)2.72795398
133neuronal action potential (GO:0019228)2.72409483
134polyol catabolic process (GO:0046174)2.71549523
135glutamate secretion (GO:0014047)2.70845072
136glyoxylate metabolic process (GO:0046487)2.70526240
137otic vesicle formation (GO:0030916)2.70179330
138branched-chain amino acid metabolic process (GO:0009081)2.70047984
139peptide biosynthetic process (GO:0043043)2.68536371
140phasic smooth muscle contraction (GO:0014821)2.68032306
141epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.67857412
142oxaloacetate metabolic process (GO:0006107)2.67856688
143trivalent inorganic cation transport (GO:0072512)2.67855899
144ferric iron transport (GO:0015682)2.67855899
145positive regulation of digestive system process (GO:0060456)2.67335804
146bicarbonate transport (GO:0015701)2.67217336
147benzene-containing compound metabolic process (GO:0042537)2.66959728
148gamma-aminobutyric acid signaling pathway (GO:0007214)2.66574058
149pharyngeal system development (GO:0060037)2.66376546
150neurotransmitter secretion (GO:0007269)2.65882102
151rhodopsin mediated signaling pathway (GO:0016056)2.64665302
152cellular anion homeostasis (GO:0030002)2.64371529
153detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64283848
154somite development (GO:0061053)2.64199876
155drug catabolic process (GO:0042737)2.64162791
156photoreceptor cell development (GO:0042461)2.62152316
157relaxation of cardiac muscle (GO:0055119)2.62089022
158vitamin D metabolic process (GO:0042359)2.61822720
159pyrimidine ribonucleoside catabolic process (GO:0046133)2.61122324
160GPI anchor metabolic process (GO:0006505)2.61062089
161inositol metabolic process (GO:0006020)2.59540750
162positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.58410135
163neurotransmitter transport (GO:0006836)2.58384707
164potassium ion import (GO:0010107)2.58080568
165hydrogen ion transmembrane transport (GO:1902600)2.57668495
166positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.56324760
167membrane repolarization (GO:0086009)2.55779655
168transmission of nerve impulse (GO:0019226)2.55467337
169dopamine biosynthetic process (GO:0042416)2.54988385
170negative regulation of multicellular organism growth (GO:0040015)2.53558051
171NAD biosynthetic process (GO:0009435)2.53484236
172negative regulation by host of viral transcription (GO:0043922)2.53234163
173neuronal action potential propagation (GO:0019227)2.52982447
174cysteine metabolic process (GO:0006534)2.52505139
175ketone body metabolic process (GO:1902224)2.52256740
176mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.51852084
177mitochondrial respiratory chain complex I assembly (GO:0032981)2.51852084
178NADH dehydrogenase complex assembly (GO:0010257)2.51852084
179negative regulation of telomere maintenance (GO:0032205)2.51513771
180locomotory exploration behavior (GO:0035641)2.51312532
181positive regulation of meiosis (GO:0045836)2.51024761
182regulation of synaptic vesicle transport (GO:1902803)2.49411826
183positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.48784051
184positive regulation of metanephros development (GO:0072216)2.48013019
185eye photoreceptor cell development (GO:0042462)2.47436249
186cornea development in camera-type eye (GO:0061303)2.46360552
187vocalization behavior (GO:0071625)2.46244053
188erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.44739814
189L-phenylalanine catabolic process (GO:0006559)2.44739814
190nephron epithelium development (GO:0072009)2.44504230
191negative regulation of hormone biosynthetic process (GO:0032353)2.44463138
192negative regulation of hormone metabolic process (GO:0032351)2.44463138
193membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.44411613
194regulation of cAMP-mediated signaling (GO:0043949)2.43982343
195response to pheromone (GO:0019236)2.43158103
196hyperosmotic salinity response (GO:0042538)2.39829656
197fluid transport (GO:0042044)2.39011998
198regulation of potassium ion transmembrane transporter activity (GO:1901016)2.38665937
199regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.38368888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.27559835
2GBX2_23144817_ChIP-Seq_PC3_Human3.33196840
3IGF1R_20145208_ChIP-Seq_DFB_Human2.61055001
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48549958
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40785099
6VDR_22108803_ChIP-Seq_LS180_Human2.40580288
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.30944722
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.25649263
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16449487
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12618025
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12401488
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08729551
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08283161
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07158130
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04070634
16FUS_26573619_Chip-Seq_HEK293_Human2.02265622
17REST_21632747_ChIP-Seq_MESCs_Mouse2.01227567
18EWS_26573619_Chip-Seq_HEK293_Human1.96637858
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90666566
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90666566
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88284501
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.87222303
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86812730
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86151291
25* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77970138
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77744852
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.75152555
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.73315840
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.72643146
30* RARB_27405468_Chip-Seq_BRAIN_Mouse1.69941112
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67890807
32SMAD4_21799915_ChIP-Seq_A2780_Human1.66185841
33DROSHA_22980978_ChIP-Seq_HELA_Human1.64327683
34TAF15_26573619_Chip-Seq_HEK293_Human1.64036540
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64019985
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.64006407
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62704176
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.58806415
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.55066405
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.53734609
41ZNF274_21170338_ChIP-Seq_K562_Hela1.50980324
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49562416
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49245358
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48996704
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48356158
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43823330
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42752339
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42729631
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39495468
50IRF1_19129219_ChIP-ChIP_H3396_Human1.38747060
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35090247
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34392143
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33944658
54TP53_16413492_ChIP-PET_HCT116_Human1.33202327
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31026723
56SOX2_19829295_ChIP-Seq_ESCs_Human1.31009605
57NANOG_19829295_ChIP-Seq_ESCs_Human1.31009605
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29832283
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.29180364
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28105766
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26923739
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.26214096
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25497551
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.24499335
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.24321324
66P300_19829295_ChIP-Seq_ESCs_Human1.24285614
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24260705
68* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22588933
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20329579
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19907491
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.19503741
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.19300173
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18879408
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18879408
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17871830
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.17729208
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16635009
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15743154
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14322914
80RNF2_27304074_Chip-Seq_NSC_Mouse1.14072942
81BCAT_22108803_ChIP-Seq_LS180_Human1.13947667
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.13375729
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.13287454
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13287454
85AR_25329375_ChIP-Seq_VCAP_Human1.12697781
86* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12665705
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10986591
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10823294
89TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09203985
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08610465
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08034554
92POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07639010
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.07446755
94STAT3_23295773_ChIP-Seq_U87_Human1.06479371
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05877159
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05862199
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05520052
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05010778
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04617336
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03672020
101TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03433730
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02764239
103STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02677373
104P53_22387025_ChIP-Seq_ESCs_Mouse1.02358616
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02148964
106SMAD3_21741376_ChIP-Seq_HESCs_Human1.01718048
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.01550739
108* CDX2_22108803_ChIP-Seq_LS180_Human1.01292084
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01267073
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00355284
111HOXB7_26014856_ChIP-Seq_BT474_Human0.99898442
112IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99833736
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.99547269
114STAT3_18555785_Chip-Seq_ESCs_Mouse0.99342148
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98553209
116AHR_22903824_ChIP-Seq_MCF-7_Human0.98392214
117ESR2_21235772_ChIP-Seq_MCF-7_Human0.96288486
118CBP_20019798_ChIP-Seq_JUKART_Human0.95484660
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95484660
120* SMAD4_21741376_ChIP-Seq_EPCs_Human0.94804202
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94759587
122* AR_19668381_ChIP-Seq_PC3_Human0.94707965
123TCF4_23295773_ChIP-Seq_U87_Human0.94583164
124TCF4_22108803_ChIP-Seq_LS180_Human0.92633362
125RING1B_27294783_Chip-Seq_ESCs_Mouse0.91240179
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90314877
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89297531
128CTCF_27219007_Chip-Seq_Bcells_Human0.89240040
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88602872
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.88201100
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87915703
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.87113217
133ER_23166858_ChIP-Seq_MCF-7_Human0.87036160
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86777445
135RXR_22108803_ChIP-Seq_LS180_Human0.86684912
136* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86506650
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86211733
138CBX2_27304074_Chip-Seq_ESCs_Mouse0.85961543
139KDM2B_26808549_Chip-Seq_REH_Human0.85152091
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84412912
141RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84355283
142AR_21572438_ChIP-Seq_LNCaP_Human0.84333548
143FLI1_21867929_ChIP-Seq_TH2_Mouse0.84220461
144RUNX2_22187159_ChIP-Seq_PCA_Human0.84027110
145TP53_18474530_ChIP-ChIP_U2OS_Human0.82990651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation7.14009817
2MP0003195_calcinosis4.24808835
3MP0001765_abnormal_ion_homeostasis3.37883692
4MP0005360_urolithiasis3.24521200
5MP0005171_absent_coat_pigmentation3.16847152
6MP0002837_dystrophic_cardiac_calcinosis2.95383676
7MP0001756_abnormal_urination2.92943940
8MP0006292_abnormal_olfactory_placode2.84659865
9MP0005332_abnormal_amino_acid2.68919923
10MP0002653_abnormal_ependyma_morphology2.68904720
11MP0003136_yellow_coat_color2.65119565
12MP0008872_abnormal_physiological_respon2.63884760
13MP0004859_abnormal_synaptic_plasticity2.55397335
14MP0009643_abnormal_urine_homeostasis2.48235865
15MP0001485_abnormal_pinna_reflex2.40604372
16MP0005636_abnormal_mineral_homeostasis2.35803543
17MP0000569_abnormal_digit_pigmentation2.35735733
18MP0009780_abnormal_chondrocyte_physiolo2.31544044
19MP0004019_abnormal_vitamin_homeostasis2.24225470
20MP0003880_abnormal_central_pattern2.21666499
21MP0005551_abnormal_eye_electrophysiolog2.14931333
22MP0003635_abnormal_synaptic_transmissio2.08329349
23MP0002102_abnormal_ear_morphology2.03608540
24MP0008961_abnormal_basal_metabolism2.02633080
25MP0004134_abnormal_chest_morphology2.01990712
26MP0010386_abnormal_urinary_bladder2.01673138
27MP0004270_analgesia2.01277660
28MP0002160_abnormal_reproductive_system1.99955493
29MP0002876_abnormal_thyroid_physiology1.98160203
30MP0008877_abnormal_DNA_methylation1.93601997
31MP0003283_abnormal_digestive_organ1.89724786
32MP0000013_abnormal_adipose_tissue1.87170517
33MP0009046_muscle_twitch1.82766483
34MP0000631_abnormal_neuroendocrine_gland1.79802896
35MP0002064_seizures1.78333443
36MP0009745_abnormal_behavioral_response1.77623390
37MP0004142_abnormal_muscle_tone1.74314792
38MP0004885_abnormal_endolymph1.73838358
39MP0002138_abnormal_hepatobiliary_system1.66266399
40MP0002136_abnormal_kidney_physiology1.65135852
41MP0002938_white_spotting1.64169698
42MP0000372_irregular_coat_pigmentation1.61413749
43MP0002909_abnormal_adrenal_gland1.59574509
44MP0001968_abnormal_touch/_nociception1.59154425
45MP0002063_abnormal_learning/memory/cond1.58050236
46MP0000538_abnormal_urinary_bladder1.55343852
47MP0005389_reproductive_system_phenotype1.53556723
48MP0002734_abnormal_mechanical_nocicepti1.53304640
49MP0004130_abnormal_muscle_cell1.49751896
50MP0005535_abnormal_body_temperature1.49668446
51MP0002736_abnormal_nociception_after1.48270963
52MP0005670_abnormal_white_adipose1.47266386
53MP0002139_abnormal_hepatobiliary_system1.45576220
54MP0005174_abnormal_tail_pigmentation1.45163480
55MP0003890_abnormal_embryonic-extraembry1.44124535
56MP0003879_abnormal_hair_cell1.42768288
57MP0002572_abnormal_emotion/affect_behav1.41553843
58MP0004133_heterotaxia1.41352088
59MP0002272_abnormal_nervous_system1.40017765
60MP0000049_abnormal_middle_ear1.39004251
61MP0004215_abnormal_myocardial_fiber1.38135685
62MP0001440_abnormal_grooming_behavior1.36342319
63MP0003122_maternal_imprinting1.35907477
64MP0002735_abnormal_chemical_nociception1.35503141
65MP0006036_abnormal_mitochondrial_physio1.33786957
66MP0003329_amyloid_beta_deposits1.33402051
67MP0002067_abnormal_sensory_capabilities1.33013915
68MP0003638_abnormal_response/metabolism_1.32272157
69MP0000230_abnormal_systemic_arterial1.29831006
70MP0002163_abnormal_gland_morphology1.27699368
71MP0005253_abnormal_eye_physiology1.24792157
72MP0001501_abnormal_sleep_pattern1.24126893
73MP0003646_muscle_fatigue1.23327087
74MP0005410_abnormal_fertilization1.20724720
75MP0003045_fibrosis1.18324891
76MP0003724_increased_susceptibility_to1.17247118
77MP0000751_myopathy1.15967510
78MP0008875_abnormal_xenobiotic_pharmacok1.15965890
79MP0001986_abnormal_taste_sensitivity1.11961496
80MP0003878_abnormal_ear_physiology1.11535285
81MP0005377_hearing/vestibular/ear_phenot1.11535285
82MP0001486_abnormal_startle_reflex1.10489283
83MP0004036_abnormal_muscle_relaxation1.10431820
84MP0005167_abnormal_blood-brain_barrier1.10273123
85MP0003937_abnormal_limbs/digits/tail_de1.08943509
86MP0002928_abnormal_bile_duct1.07840008
87MP0005646_abnormal_pituitary_gland1.07437835
88MP0002733_abnormal_thermal_nociception1.07358907
89MP0009250_abnormal_appendicular_skeleto1.05210129
90MP0001944_abnormal_pancreas_morphology1.04915902
91MP0001970_abnormal_pain_threshold1.04015633
92MP0006276_abnormal_autonomic_nervous1.02527728
93MP0003252_abnormal_bile_duct1.01440506
94MP0003011_delayed_dark_adaptation0.99533477
95MP0002078_abnormal_glucose_homeostasis0.99525948
96MP0004484_altered_response_of0.96154419
97MP0000613_abnormal_salivary_gland0.95825596
98MP0010329_abnormal_lipoprotein_level0.95230168
99MP0000678_abnormal_parathyroid_gland0.94206197
100MP0002822_catalepsy0.93619285
101MP0005386_behavior/neurological_phenoty0.93324024
102MP0004924_abnormal_behavior0.93324024
103MP0002069_abnormal_eating/drinking_beha0.93080958
104MP0002557_abnormal_social/conspecific_i0.93038198
105MP0005083_abnormal_biliary_tract0.92214066
106MP0004147_increased_porphyrin_level0.91670018
107MP0001502_abnormal_circadian_rhythm0.91223944
108MP0004084_abnormal_cardiac_muscle0.89797756
109MP0003119_abnormal_digestive_system0.89503691
110MP0005195_abnormal_posterior_eye0.88822994
111MP0005620_abnormal_muscle_contractility0.86827788
112MP0000026_abnormal_inner_ear0.86094832
113MP0002066_abnormal_motor_capabilities/c0.85957927
114MP0002168_other_aberrant_phenotype0.85299752
115MP0001963_abnormal_hearing_physiology0.84876344
116MP0001664_abnormal_digestion0.84744348
117MP0003953_abnormal_hormone_level0.84556486
118MP0005379_endocrine/exocrine_gland_phen0.83687273
119MP0005584_abnormal_enzyme/coenzyme_acti0.83202257
120MP0004145_abnormal_muscle_electrophysio0.82403063
121MP0000747_muscle_weakness0.80698075
122MP0002972_abnormal_cardiac_muscle0.80486769
123MP0000383_abnormal_hair_follicle0.80417143
124MP0004085_abnormal_heartbeat0.80361908
125MP0005464_abnormal_platelet_physiology0.79754492
126MP0005085_abnormal_gallbladder_physiolo0.79713387
127MP0008789_abnormal_olfactory_epithelium0.79087578
128MP0004742_abnormal_vestibular_system0.78392527
129MP0003633_abnormal_nervous_system0.78035527
130MP0000427_abnormal_hair_cycle0.77248623
131MP0002693_abnormal_pancreas_physiology0.77166390
132MP0004858_abnormal_nervous_system0.77102948
133MP0005084_abnormal_gallbladder_morpholo0.75240403
134MP0005423_abnormal_somatic_nervous0.74274967
135MP0010234_abnormal_vibrissa_follicle0.73870085
136MP0001958_emphysema0.73796711
137MP0004233_abnormal_muscle_weight0.73784431
138MP0002896_abnormal_bone_mineralization0.73672114
139MP0002752_abnormal_somatic_nervous0.73602919
140MP0002282_abnormal_trachea_morphology0.73548783
141MP0005058_abnormal_lysosome_morphology0.72920539
142MP0001919_abnormal_reproductive_system0.72800105
143MP0002751_abnormal_autonomic_nervous0.72610461
144MP0005645_abnormal_hypothalamus_physiol0.71158249
145MP0008569_lethality_at_weaning0.70940009
146MP0001984_abnormal_olfaction0.70298552
147MP0002638_abnormal_pupillary_reflex0.69653001
148MP0006072_abnormal_retinal_apoptosis0.68875501
149MP0005075_abnormal_melanosome_morpholog0.68459485
150MP0009764_decreased_sensitivity_to0.68456075
151MP0003183_abnormal_peptide_metabolism0.68334858
152MP0005330_cardiomyopathy0.68266418
153MP0002095_abnormal_skin_pigmentation0.68062662
154MP0002229_neurodegeneration0.67760102
155MP0003787_abnormal_imprinting0.67699595
156MP0003959_abnormal_lean_body0.67517411
157MP0002277_abnormal_respiratory_mucosa0.66921802

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)8.07804829
2Hypokalemic alkalosis (HP:0001949)7.84820310
3Increased circulating renin level (HP:0000848)7.64977348
4Hyperactive renin-angiotensin system (HP:0000841)7.18503617
5Abnormality of chloride homeostasis (HP:0011422)6.76096657
6Polyuria (HP:0000103)6.64556233
7Hypomagnesemia (HP:0002917)6.53945237
8Abnormal urine output (HP:0012590)6.16890976
9Gout (HP:0001997)5.66617051
10Abnormality of renal excretion (HP:0011036)5.64881857
11Abnormality of magnesium homeostasis (HP:0004921)5.64790466
12Hyperaldosteronism (HP:0000859)5.56084810
13Abnormal drinking behavior (HP:0030082)5.39658423
14Polydipsia (HP:0001959)5.39658423
15Renal salt wasting (HP:0000127)5.26874875
16Tetany (HP:0001281)5.14331257
17Abnormality of renin-angiotensin system (HP:0000847)5.07165926
18Pancreatic cysts (HP:0001737)4.79391307
19Alkalosis (HP:0001948)4.65888948
20Genetic anticipation (HP:0003743)4.48186941
21Pendular nystagmus (HP:0012043)4.40366697
22Hypokalemia (HP:0002900)4.31902456
23Pancreatic fibrosis (HP:0100732)4.20355087
24True hermaphroditism (HP:0010459)4.12258061
25Progressive cerebellar ataxia (HP:0002073)3.72202035
26Increased purine levels (HP:0004368)3.71802574
27Hyperuricemia (HP:0002149)3.71802574
28Abnormality of potassium homeostasis (HP:0011042)3.64078086
29Ketoacidosis (HP:0001993)3.58084113
30Abolished electroretinogram (ERG) (HP:0000550)3.47145177
31Proximal tubulopathy (HP:0000114)3.34297257
32Abnormality of the renal cortex (HP:0011035)3.30133439
33Nephronophthisis (HP:0000090)3.23700347
34Keratoconus (HP:0000563)3.22597659
35Increased corneal curvature (HP:0100692)3.22597659
36Hypercalciuria (HP:0002150)3.19644016
37Congenital stationary night blindness (HP:0007642)3.07377844
38Abnormality of midbrain morphology (HP:0002418)3.00322561
39Molar tooth sign on MRI (HP:0002419)3.00322561
40Gaze-evoked nystagmus (HP:0000640)2.99228319
41Adrenal overactivity (HP:0002717)2.97686116
42Decreased central vision (HP:0007663)2.97100383
43Decreased circulating renin level (HP:0003351)2.95856543
44Cystic liver disease (HP:0006706)2.94358005
45Abnormality of purine metabolism (HP:0004352)2.92180872
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.80273709
47Congenital sensorineural hearing impairment (HP:0008527)2.79046106
48Severe visual impairment (HP:0001141)2.77242813
49Generalized aminoaciduria (HP:0002909)2.76298917
50Abnormality of sodium homeostasis (HP:0010931)2.75979212
513-Methylglutaconic aciduria (HP:0003535)2.70122199
52Ketosis (HP:0001946)2.66524342
53Type II lissencephaly (HP:0007260)2.65606522
54Hyperglycinuria (HP:0003108)2.62233477
55Abnormality of urine glucose concentration (HP:0011016)2.58416607
56Glycosuria (HP:0003076)2.58416607
57Agitation (HP:0000713)2.58092588
58Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.54939596
59Short 1st metacarpal (HP:0010034)2.54939596
60Renal cortical cysts (HP:0000803)2.53277615
61Hyponatremia (HP:0002902)2.52093249
62Furrowed tongue (HP:0000221)2.50936708
63Abnormal rod and cone electroretinograms (HP:0008323)2.46021417
64Chorioretinal atrophy (HP:0000533)2.45559871
65Methylmalonic acidemia (HP:0002912)2.44628451
66Renal tubular acidosis (HP:0001947)2.44166381
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.43140530
68Abnormality of fatty-acid metabolism (HP:0004359)2.42618607
69Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.42082882
70Carpal bone hypoplasia (HP:0001498)2.39913906
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.37426750
72Hyperphosphaturia (HP:0003109)2.31735662
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.29963816
74Absent/shortened dynein arms (HP:0200106)2.29963816
75Acanthocytosis (HP:0001927)2.28711007
76Acute encephalopathy (HP:0006846)2.28514426
77Attenuation of retinal blood vessels (HP:0007843)2.26916753
78Abnormality of the nasal septum (HP:0000419)2.26820403
79Nephrocalcinosis (HP:0000121)2.24800633
80Hemiparesis (HP:0001269)2.24585683
81Focal motor seizures (HP:0011153)2.21866006
82Short phalanx of the thumb (HP:0009660)2.21829295
83Abnormality of the renal collecting system (HP:0004742)2.19595673
84Pheochromocytoma (HP:0002666)2.19433581
85Hemiplegia (HP:0002301)2.19092036
86Asplenia (HP:0001746)2.18685052
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.18398776
88Dehydration (HP:0001944)2.18201234
89Abnormality of the 1st metacarpal (HP:0010009)2.18023382
90Chronic hepatic failure (HP:0100626)2.17279138
91Abnormal urine phosphate concentration (HP:0012599)2.16666056
92Hypotension (HP:0002615)2.16299511
93Hypothermia (HP:0002045)2.16057027
94Aplasia/Hypoplasia of the tibia (HP:0005772)2.16041121
95Congenital hepatic fibrosis (HP:0002612)2.13513543
96Sclerocornea (HP:0000647)2.13358223
97Congenital, generalized hypertrichosis (HP:0004540)2.12921265
98Aplasia/Hypoplasia of the spleen (HP:0010451)2.12527351
99Aplasia/Hypoplasia of the tongue (HP:0010295)2.10587607
100Abnormal mitochondria in muscle tissue (HP:0008316)2.09650961
101Optic nerve hypoplasia (HP:0000609)2.08966774
102Abnormality of calcium-phosphate metabolism (HP:0100530)2.07218288
103Porencephaly (HP:0002132)2.06604899
104Abnormality of serine family amino acid metabolism (HP:0010894)2.06232954
105Abnormality of glycine metabolism (HP:0010895)2.06232954
106Hyperkalemia (HP:0002153)2.05929760
107Male pseudohermaphroditism (HP:0000037)2.04342791
108Visual hallucinations (HP:0002367)2.04133456
109Abnormal eating behavior (HP:0100738)2.03483917
110Acute necrotizing encephalopathy (HP:0006965)2.02668365
111Abnormality of binocular vision (HP:0011514)2.02154140
112Diplopia (HP:0000651)2.02154140
113Medial flaring of the eyebrow (HP:0010747)1.99996035
114Tubulointerstitial fibrosis (HP:0005576)1.98077557
115Abnormality of the proximal phalanges of the hand (HP:0009834)1.97976019
116Hyperventilation (HP:0002883)1.97403084
117Small hand (HP:0200055)1.95866545
118Bony spicule pigmentary retinopathy (HP:0007737)1.95672686
119Abnormality of DNA repair (HP:0003254)1.94697868
120Ectopic kidney (HP:0000086)1.92862645
121Abnormal ciliary motility (HP:0012262)1.92427082
122Neuroendocrine neoplasm (HP:0100634)1.92341242
123Abnormality of chromosome stability (HP:0003220)1.92001709
124Amelogenesis imperfecta (HP:0000705)1.91471089
125Vomiting (HP:0002013)1.90628502
126Anencephaly (HP:0002323)1.89406267
127Abnormality of renal resorption (HP:0011038)1.89315549
128Inability to walk (HP:0002540)1.88611095
129Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.86717068
130Abnormality of the ileum (HP:0001549)1.86116881
131Hypophosphatemia (HP:0002148)1.85224947
132Methylmalonic aciduria (HP:0012120)1.84978503
133Meckel diverticulum (HP:0002245)1.83725945
134Absent thumb (HP:0009777)1.82842155
135Short hallux (HP:0010109)1.82747398
136Tubular atrophy (HP:0000092)1.80410327
137Potter facies (HP:0002009)1.79832211
138Facial shape deformation (HP:0011334)1.79832211
139IgG deficiency (HP:0004315)1.79442397
140Hypoglycemic coma (HP:0001325)1.79060635
141Thyroid-stimulating hormone excess (HP:0002925)1.79051358
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78653521
143Abnormality of alanine metabolism (HP:0010916)1.78653521
144Hyperalaninemia (HP:0003348)1.78653521
145Renal tubular dysfunction (HP:0000124)1.77876276
146Nephrolithiasis (HP:0000787)1.77627901
147Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77302991
148Progressive macrocephaly (HP:0004481)1.77072096
149Delayed epiphyseal ossification (HP:0002663)1.76969830
150Hypoplastic iliac wings (HP:0002866)1.76689935
151Abnormal respiratory motile cilium morphology (HP:0005938)1.76107938
152Abnormal respiratory epithelium morphology (HP:0012253)1.76107938
153Dialeptic seizures (HP:0011146)1.74703102
154Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.74332611
155Postaxial foot polydactyly (HP:0001830)1.73568714
156Hamartoma of the eye (HP:0010568)1.73166742
157Hyperinsulinemic hypoglycemia (HP:0000825)1.73074932
158Progressive inability to walk (HP:0002505)1.71958883
159Tinnitus (HP:0000360)1.71502482
160Tachypnea (HP:0002789)1.71389566
161Cerebellar dysplasia (HP:0007033)1.70474474
162Abnormality of nucleobase metabolism (HP:0010932)1.70047986
163Metabolic acidosis (HP:0001942)1.65923571
164Polyphagia (HP:0002591)1.65358694
165Abnormality of dicarboxylic acid metabolism (HP:0010995)1.63247226
166Dicarboxylic aciduria (HP:0003215)1.63247226
167Atonic seizures (HP:0010819)1.62875187
168Abnormality of the renal medulla (HP:0100957)1.62415198
169Enlarged kidneys (HP:0000105)1.60887024
170Focal seizures (HP:0007359)1.60485198
171Lethargy (HP:0001254)1.59822190
172Anxiety (HP:0000739)1.59390504
173Confusion (HP:0001289)1.59008556
174Cerebral edema (HP:0002181)1.58761028
175Myokymia (HP:0002411)1.58662919
176Generalized muscle weakness (HP:0003324)1.58374958
177Irritability (HP:0000737)1.58280609
178Goiter (HP:0000853)1.57353232
179Chronic bronchitis (HP:0004469)1.56651041
180Tubulointerstitial abnormality (HP:0001969)1.55819344
181Symptomatic seizures (HP:0011145)1.55233604
182Epileptic encephalopathy (HP:0200134)1.54584540
183Delayed CNS myelination (HP:0002188)1.53178351
184Hyperphosphatemia (HP:0002905)1.52856651
185Abnormal pancreas size (HP:0012094)1.51122225
186Widely patent fontanelles and sutures (HP:0004492)1.49629769
187Large eyes (HP:0001090)1.49214298
188Mitochondrial inheritance (HP:0001427)1.48369304
189Hyperglycinemia (HP:0002154)1.48359146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK38.23298917
2WNK46.26836739
3OXSR15.74057055
4ADRBK23.88607850
5GRK13.51928790
6BMPR1B3.17188134
7LATS12.93754487
8ACVR1B2.73741382
9STK392.66608244
10ZAK2.60935000
11TAOK32.54412102
12NTRK32.38561739
13PDK42.37781433
14PDK32.37781433
15NUAK12.19677781
16INSRR2.14429745
17MAP4K22.07445030
18MAP3K42.00598886
19SGK4941.82968146
20SGK2231.82968146
21WNK11.81669578
22TXK1.77931117
23MAPK131.74960878
24EPHA41.65088377
25BCKDK1.53461230
26NTRK11.52917021
27TNIK1.52317199
28STK381.43004964
29PDK21.42200179
30STK38L1.39940368
31MAP3K91.39811673
32SGK21.39633307
33MAP2K71.29417308
34TLK11.27801990
35MINK11.25844771
36CASK1.24841689
37TAF11.22582584
38MAPK151.21306420
39NLK1.19410973
40EPHA31.17685979
41MAP3K121.15665233
42MAP2K41.15494864
43PNCK1.12130556
44PRKD31.11843636
45RIPK41.11636716
46STK31.09766110
47PAK31.09722342
48MAP3K21.08435153
49SGK31.06508047
50MYLK1.05005672
51DAPK21.03935201
52TEC1.03578568
53VRK10.97278260
54MUSK0.96564946
55CAMKK20.96229388
56PTK2B0.93716565
57CSNK1A1L0.90981236
58BRSK20.89183126
59KSR20.85432906
60GRK60.81066486
61SGK10.79199412
62NEK10.78320983
63GRK50.78122871
64CSNK1G10.77993783
65DYRK20.76123572
66MARK10.75989437
67MAPKAPK30.75580347
68IKBKB0.71604048
69PIK3CG0.70241805
70PINK10.68632981
71CDC42BPA0.68199112
72PAK60.68176427
73FER0.68069479
74CSNK1G30.67459720
75CDK50.66109547
76DAPK10.65980495
77EIF2AK30.65903907
78PLK20.64832394
79ERBB20.63224927
80TRIM280.62083283
81ARAF0.61918150
82NTRK20.61743120
83PRKCH0.61595194
84PRKCG0.58852807
85CSNK1G20.58745859
86MAPKAPK50.58290132
87SYK0.57813673
88FRK0.56518129
89PRKAA10.56432373
90LMTK20.54801540
91CAMK2A0.54127057
92KSR10.54018044
93TGFBR10.53719964
94CAMK2B0.53167554
95PKN10.49926993
96CAMKK10.49732481
97BMPR20.49307225
98PRKAA20.47724907
99ITK0.47565404
100CDK80.45754322
101PTK20.44934484
102UHMK10.44783371
103PRKCQ0.44285992
104PDPK10.44098463
105SCYL20.43938778
106TIE10.43217828
107RPS6KA50.42830008
108CAMK1G0.42688515
109FLT30.42080979
110PRKCE0.41514741
111PIK3CA0.41272643
112MAP2K60.41182544
113PRKCI0.40799471
114PRKD10.40122784
115GRK70.39193171
116RET0.38956512
117LATS20.38862222
118NME10.38425764
119CSNK1D0.38191492
120BTK0.37949746
121MAP3K10.37816962
122PDK10.36975353
123MAP2K10.36525179
124PHKG20.36299317
125PHKG10.36299317
126PRKACA0.36188861
127CAMK2D0.36180054
128MELK0.35348762
129MAP2K20.35193062
130VRK20.34559845
131OBSCN0.34146399
132IRAK10.34006104
133IGF1R0.33583017
134TNK20.33406160
135AKT30.33147629
136STK110.32240002
137ABL10.32008182
138CDK90.31579274
139PLK30.31538057
140BLK0.31410978
141NEK90.31272386
142MKNK20.30553427
143SIK30.27850759
144CAMK2G0.26864333
145PRKACG0.26728894
146CDK190.26492823
147PRKCA0.24553557
148SIK20.23591927
149CSNK1A10.23523490
150RPS6KA30.23266490
151MAP3K70.23084271
152PRKCZ0.22798307
153MARK20.21103151
154ADRBK10.20730954
155CAMK10.20687320
156MST40.20119322
157MST1R0.20113897
158CDK140.17095121
159PRKD20.16353513
160BCR0.15812043
161HIPK20.15321396

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.57826934
2Collecting duct acid secretion_Homo sapiens_hsa049663.12638300
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.09001002
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.05852781
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.92163752
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.69629065
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.48826390
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.44409035
9Butanoate metabolism_Homo sapiens_hsa006502.43160182
10Oxidative phosphorylation_Homo sapiens_hsa001902.32640952
11Synaptic vesicle cycle_Homo sapiens_hsa047212.28759143
12Propanoate metabolism_Homo sapiens_hsa006402.26424136
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23472741
14Homologous recombination_Homo sapiens_hsa034402.18562316
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.11176566
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94457202
17Selenocompound metabolism_Homo sapiens_hsa004501.93552121
18Pyruvate metabolism_Homo sapiens_hsa006201.92723978
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.87761097
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.85969607
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85223498
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76666037
23Insulin secretion_Homo sapiens_hsa049111.76255784
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75383909
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69303000
26Sulfur metabolism_Homo sapiens_hsa009201.66535807
27Parkinsons disease_Homo sapiens_hsa050121.66391703
28Nicotine addiction_Homo sapiens_hsa050331.65659170
29Linoleic acid metabolism_Homo sapiens_hsa005911.65253447
30Cardiac muscle contraction_Homo sapiens_hsa042601.62725169
31Vibrio cholerae infection_Homo sapiens_hsa051101.61964648
32Gastric acid secretion_Homo sapiens_hsa049711.59568666
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55741056
34Chemical carcinogenesis_Homo sapiens_hsa052041.50085428
35Alzheimers disease_Homo sapiens_hsa050101.46234475
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41886779
37Amphetamine addiction_Homo sapiens_hsa050311.39911177
38Thyroid hormone synthesis_Homo sapiens_hsa049181.38879461
39Long-term potentiation_Homo sapiens_hsa047201.36971984
40GABAergic synapse_Homo sapiens_hsa047271.36568327
41Fanconi anemia pathway_Homo sapiens_hsa034601.36139186
42Basal transcription factors_Homo sapiens_hsa030221.32861759
43Bile secretion_Homo sapiens_hsa049761.32334938
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.29684206
45Systemic lupus erythematosus_Homo sapiens_hsa053221.27622261
46Taste transduction_Homo sapiens_hsa047421.27300954
47Circadian entrainment_Homo sapiens_hsa047131.25966452
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24243340
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19890752
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.19733181
51Primary immunodeficiency_Homo sapiens_hsa053401.19087535
52Fatty acid degradation_Homo sapiens_hsa000711.18722627
53Mineral absorption_Homo sapiens_hsa049781.17678108
54One carbon pool by folate_Homo sapiens_hsa006701.17640210
55Salivary secretion_Homo sapiens_hsa049701.16642008
56Tryptophan metabolism_Homo sapiens_hsa003801.14517441
57Huntingtons disease_Homo sapiens_hsa050161.10339232
58Carbon metabolism_Homo sapiens_hsa012001.10007979
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08839810
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08708675
61Renin secretion_Homo sapiens_hsa049241.08199163
62Morphine addiction_Homo sapiens_hsa050321.08040139
63Ether lipid metabolism_Homo sapiens_hsa005651.06775656
64Cyanoamino acid metabolism_Homo sapiens_hsa004601.05928444
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02867299
66Peroxisome_Homo sapiens_hsa041461.01931873
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01794280
68Dopaminergic synapse_Homo sapiens_hsa047281.00758713
69Glutamatergic synapse_Homo sapiens_hsa047240.97910764
70Cocaine addiction_Homo sapiens_hsa050300.96959845
71Retinol metabolism_Homo sapiens_hsa008300.95488039
72Dorso-ventral axis formation_Homo sapiens_hsa043200.95278913
73ABC transporters_Homo sapiens_hsa020100.92605015
74Caffeine metabolism_Homo sapiens_hsa002320.91848128
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91847939
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90015408
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89596349
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88891164
79Fatty acid metabolism_Homo sapiens_hsa012120.88303690
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86291213
81Protein digestion and absorption_Homo sapiens_hsa049740.86290357
82Olfactory transduction_Homo sapiens_hsa047400.85479442
83Melanoma_Homo sapiens_hsa052180.85448807
84Pancreatic secretion_Homo sapiens_hsa049720.84689574
85Fatty acid biosynthesis_Homo sapiens_hsa000610.83019441
86Renin-angiotensin system_Homo sapiens_hsa046140.80517729
87Fat digestion and absorption_Homo sapiens_hsa049750.80353858
88Serotonergic synapse_Homo sapiens_hsa047260.80187545
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80175737
90Glucagon signaling pathway_Homo sapiens_hsa049220.79878959
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77862746
92beta-Alanine metabolism_Homo sapiens_hsa004100.76429311
93Alcoholism_Homo sapiens_hsa050340.75486812
94Asthma_Homo sapiens_hsa053100.74677126
95Arachidonic acid metabolism_Homo sapiens_hsa005900.74511406
96Sphingolipid metabolism_Homo sapiens_hsa006000.73254534
97Type II diabetes mellitus_Homo sapiens_hsa049300.73176704
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70700673
99Hematopoietic cell lineage_Homo sapiens_hsa046400.69758461
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68970994
101RNA polymerase_Homo sapiens_hsa030200.68568923
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68559905
103Protein export_Homo sapiens_hsa030600.68315055
104Cholinergic synapse_Homo sapiens_hsa047250.66933455
105Basal cell carcinoma_Homo sapiens_hsa052170.66001626
106Vitamin digestion and absorption_Homo sapiens_hsa049770.64106487
107Phenylalanine metabolism_Homo sapiens_hsa003600.63970285
108Hedgehog signaling pathway_Homo sapiens_hsa043400.62860597
109Calcium signaling pathway_Homo sapiens_hsa040200.62200815
110Long-term depression_Homo sapiens_hsa047300.61886215
111Oxytocin signaling pathway_Homo sapiens_hsa049210.57850557
112Ovarian steroidogenesis_Homo sapiens_hsa049130.56728649
113Fructose and mannose metabolism_Homo sapiens_hsa000510.56633555
114cAMP signaling pathway_Homo sapiens_hsa040240.56410100
115Starch and sucrose metabolism_Homo sapiens_hsa005000.55734988
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54301651
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.54088422
118RNA degradation_Homo sapiens_hsa030180.53832128
119Glycerolipid metabolism_Homo sapiens_hsa005610.53731698
120Platelet activation_Homo sapiens_hsa046110.52273902
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51975258
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51574297
123N-Glycan biosynthesis_Homo sapiens_hsa005100.50593596
124Arginine and proline metabolism_Homo sapiens_hsa003300.50200814
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.48413112
126Regulation of autophagy_Homo sapiens_hsa041400.46681738
127GnRH signaling pathway_Homo sapiens_hsa049120.46552889
128Estrogen signaling pathway_Homo sapiens_hsa049150.44392775
129Other glycan degradation_Homo sapiens_hsa005110.43807314
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43166009
131Gap junction_Homo sapiens_hsa045400.42982491
132Lysosome_Homo sapiens_hsa041420.42818799
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41936778
134Dilated cardiomyopathy_Homo sapiens_hsa054140.41768341
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41147225
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40677738
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40591314
138Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40454299
139Steroid biosynthesis_Homo sapiens_hsa001000.39549164
140Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38266733
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37917355
142Lysine degradation_Homo sapiens_hsa003100.36949875
143Circadian rhythm_Homo sapiens_hsa047100.36721773
144Choline metabolism in cancer_Homo sapiens_hsa052310.35875021
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35857171
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35716046
147Biosynthesis of amino acids_Homo sapiens_hsa012300.35177490
148Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34388714
149Purine metabolism_Homo sapiens_hsa002300.34151352
150Histidine metabolism_Homo sapiens_hsa003400.33074084
151Inositol phosphate metabolism_Homo sapiens_hsa005620.32756601
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32505842
153Nitrogen metabolism_Homo sapiens_hsa009100.32152364

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