

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | pyrimidine nucleobase catabolic process (GO:0006208) | 5.11647235 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.02323730 |
| 3 | synaptic vesicle exocytosis (GO:0016079) | 4.62832720 |
| 4 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.51456297 |
| 5 | presynaptic membrane organization (GO:0097090) | 4.37185553 |
| 6 | receptor recycling (GO:0001881) | 4.35853346 |
| 7 | vocalization behavior (GO:0071625) | 4.31267885 |
| 8 | neuron cell-cell adhesion (GO:0007158) | 4.31246609 |
| 9 | glutamate secretion (GO:0014047) | 4.28630474 |
| 10 | nucleobase catabolic process (GO:0046113) | 4.26036581 |
| 11 | protein localization to synapse (GO:0035418) | 4.22696364 |
| 12 | cilium or flagellum-dependent cell motility (GO:0001539) | 4.22391088 |
| 13 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.11389042 |
| 14 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.04749507 |
| 15 | protein localization to cilium (GO:0061512) | 4.00936962 |
| 16 | synaptic vesicle maturation (GO:0016188) | 3.92326007 |
| 17 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.86048651 |
| 18 | locomotory exploration behavior (GO:0035641) | 3.76786674 |
| 19 | nonmotile primary cilium assembly (GO:0035058) | 3.76738207 |
| 20 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.76419712 |
| 21 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.73541146 |
| 22 | proline transport (GO:0015824) | 3.72498738 |
| 23 | cilium movement (GO:0003341) | 3.68504040 |
| 24 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.66481243 |
| 25 | regulation of synaptic vesicle transport (GO:1902803) | 3.65834124 |
| 26 | calcium ion-dependent exocytosis (GO:0017156) | 3.61750077 |
| 27 | axonemal dynein complex assembly (GO:0070286) | 3.60404825 |
| 28 | glutamate receptor signaling pathway (GO:0007215) | 3.59092374 |
| 29 | epithelial cilium movement (GO:0003351) | 3.52792754 |
| 30 | establishment of nucleus localization (GO:0040023) | 3.51913260 |
| 31 | neurotransmitter secretion (GO:0007269) | 3.49768279 |
| 32 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.49528094 |
| 33 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.49419960 |
| 34 | exploration behavior (GO:0035640) | 3.49362723 |
| 35 | neuronal action potential propagation (GO:0019227) | 3.48238934 |
| 36 | neuron recognition (GO:0008038) | 3.45130429 |
| 37 | neurofilament cytoskeleton organization (GO:0060052) | 3.44422161 |
| 38 | synaptic transmission, glutamatergic (GO:0035249) | 3.37392343 |
| 39 | neuron-neuron synaptic transmission (GO:0007270) | 3.34682756 |
| 40 | dendritic spine morphogenesis (GO:0060997) | 3.34495565 |
| 41 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.34030240 |
| 42 | regulation of vesicle fusion (GO:0031338) | 3.33153634 |
| 43 | membrane depolarization during action potential (GO:0086010) | 3.29160991 |
| 44 | one-carbon compound transport (GO:0019755) | 3.28375611 |
| 45 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.27414695 |
| 46 | behavioral response to nicotine (GO:0035095) | 3.27252272 |
| 47 | short-term memory (GO:0007614) | 3.26199586 |
| 48 | layer formation in cerebral cortex (GO:0021819) | 3.25101293 |
| 49 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.24818554 |
| 50 | acrosome reaction (GO:0007340) | 3.21631367 |
| 51 | positive regulation of synapse assembly (GO:0051965) | 3.20982214 |
| 52 | startle response (GO:0001964) | 3.19479226 |
| 53 | central nervous system neuron axonogenesis (GO:0021955) | 3.13508265 |
| 54 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.10883002 |
| 55 | sperm motility (GO:0030317) | 3.09193856 |
| 56 | dendrite morphogenesis (GO:0048813) | 3.05999076 |
| 57 | detection of calcium ion (GO:0005513) | 3.05706784 |
| 58 | vesicle transport along microtubule (GO:0047496) | 3.05638375 |
| 59 | regulation of cilium movement (GO:0003352) | 3.05116774 |
| 60 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.04896861 |
| 61 | cell migration in hindbrain (GO:0021535) | 3.04724710 |
| 62 | neurotransmitter transport (GO:0006836) | 3.04024157 |
| 63 | synaptic vesicle endocytosis (GO:0048488) | 3.02806596 |
| 64 | axonal fasciculation (GO:0007413) | 3.02678409 |
| 65 | innervation (GO:0060384) | 3.02033498 |
| 66 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.00765465 |
| 67 | auditory behavior (GO:0031223) | 3.00709404 |
| 68 | regulation of postsynaptic membrane potential (GO:0060078) | 2.99581906 |
| 69 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.99127278 |
| 70 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.98185458 |
| 71 | mating behavior (GO:0007617) | 2.97913915 |
| 72 | regulation of neurotransmitter secretion (GO:0046928) | 2.96997545 |
| 73 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.96652766 |
| 74 | transmission of nerve impulse (GO:0019226) | 2.96417514 |
| 75 | gamma-aminobutyric acid transport (GO:0015812) | 2.96014598 |
| 76 | cornea development in camera-type eye (GO:0061303) | 2.95096518 |
| 77 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.94487931 |
| 78 | brain morphogenesis (GO:0048854) | 2.94015221 |
| 79 | positive regulation of membrane potential (GO:0045838) | 2.93427198 |
| 80 | inner ear receptor stereocilium organization (GO:0060122) | 2.91511643 |
| 81 | regulation of synapse structural plasticity (GO:0051823) | 2.91120104 |
| 82 | activation of protein kinase A activity (GO:0034199) | 2.90557528 |
| 83 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 2.88661255 |
| 84 | adult walking behavior (GO:0007628) | 2.88423118 |
| 85 | adult behavior (GO:0030534) | 2.87223766 |
| 86 | suckling behavior (GO:0001967) | 2.84467688 |
| 87 | sensory perception of smell (GO:0007608) | 2.83995742 |
| 88 | organelle transport along microtubule (GO:0072384) | 2.83822185 |
| 89 | membrane depolarization (GO:0051899) | 2.83128864 |
| 90 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.82512000 |
| 91 | behavioral response to cocaine (GO:0048148) | 2.82306590 |
| 92 | female mating behavior (GO:0060180) | 2.82305600 |
| 93 | retinal ganglion cell axon guidance (GO:0031290) | 2.81100326 |
| 94 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.81015876 |
| 95 | regulation of female receptivity (GO:0045924) | 2.80133696 |
| 96 | regulation of synaptic plasticity (GO:0048167) | 2.79890449 |
| 97 | long-term memory (GO:0007616) | 2.79561893 |
| 98 | fear response (GO:0042596) | 2.78754029 |
| 99 | presynaptic membrane assembly (GO:0097105) | 2.77149063 |
| 100 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 2.77002510 |
| 101 | substrate-independent telencephalic tangential migration (GO:0021826) | 2.77002510 |
| 102 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.76380704 |
| 103 | regulation of protein kinase A signaling (GO:0010738) | 2.76364281 |
| 104 | regulation of synapse maturation (GO:0090128) | 2.76321241 |
| 105 | synapse organization (GO:0050808) | 2.75711558 |
| 106 | behavioral defense response (GO:0002209) | 2.75326858 |
| 107 | behavioral fear response (GO:0001662) | 2.75326858 |
| 108 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.74895664 |
| 109 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.74422270 |
| 110 | cilium morphogenesis (GO:0060271) | 2.74331223 |
| 111 | establishment of synaptic vesicle localization (GO:0097480) | 2.74095115 |
| 112 | synaptic vesicle transport (GO:0048489) | 2.74095115 |
| 113 | regulation of synapse assembly (GO:0051963) | 2.73920395 |
| 114 | regulation of neurotransmitter transport (GO:0051588) | 2.73830346 |
| 115 | nerve growth factor signaling pathway (GO:0038180) | 2.72962929 |
| 116 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.72936738 |
| 117 | negative regulation of Rho protein signal transduction (GO:0035024) | 2.72126300 |
| 118 | postsynaptic membrane organization (GO:0001941) | 2.71872181 |
| 119 | regulation of neurotransmitter levels (GO:0001505) | 2.71705543 |
| 120 | ATP hydrolysis coupled proton transport (GO:0015991) | 2.70820949 |
| 121 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 2.70820949 |
| 122 | membrane hyperpolarization (GO:0060081) | 2.70689368 |
| 123 | positive regulation of mitochondrial fission (GO:0090141) | 2.69690233 |
| 124 | intraciliary transport (GO:0042073) | 2.69502414 |
| 125 | hindbrain development (GO:0030902) | 2.69140295 |
| 126 | response to histamine (GO:0034776) | 2.68915268 |
| 127 | axon cargo transport (GO:0008088) | 2.68452272 |
| 128 | regulation of microtubule-based movement (GO:0060632) | 2.68449613 |
| 129 | learning (GO:0007612) | 2.68310790 |
| 130 | synapse assembly (GO:0007416) | 2.67898760 |
| 131 | response to auditory stimulus (GO:0010996) | 2.67448673 |
| 132 | synaptic transmission (GO:0007268) | 2.67131976 |
| 133 | serotonin metabolic process (GO:0042428) | 2.66892030 |
| 134 | positive regulation of neurotransmitter transport (GO:0051590) | 2.66525924 |
| 135 | long-term synaptic potentiation (GO:0060291) | 2.66300214 |
| 136 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.65729393 |
| 137 | acrosome assembly (GO:0001675) | 2.65493661 |
| 138 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.65402984 |
| 139 | establishment of mitochondrion localization (GO:0051654) | 2.64792083 |
| 140 | cellular potassium ion homeostasis (GO:0030007) | 2.64238516 |
| 141 | response to amphetamine (GO:0001975) | 2.63427332 |
| 142 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.63206818 |
| 143 | establishment of vesicle localization (GO:0051650) | 2.62949091 |
| 144 | regulation of synapse organization (GO:0050807) | 2.59307783 |
| 145 | regulation of neuron projection regeneration (GO:0070570) | 2.56190328 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.76480156 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.44036060 |
| 3 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.54337789 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.48338095 |
| 5 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.47255651 |
| 6 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.46472689 |
| 7 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.31312698 |
| 8 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.29022962 |
| 9 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.28149103 |
| 10 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.16708940 |
| 11 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.09086216 |
| 12 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.05795889 |
| 13 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.05523534 |
| 14 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.02581733 |
| 15 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.96986329 |
| 16 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.94897379 |
| 17 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.94124483 |
| 18 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.94124483 |
| 19 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.93248207 |
| 20 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.93216035 |
| 21 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.91701632 |
| 22 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.87997605 |
| 23 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.84460802 |
| 24 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.84370762 |
| 25 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.82592549 |
| 26 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.79542496 |
| 27 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.78320853 |
| 28 | * EWS_26573619_Chip-Seq_HEK293_Human | 1.77812049 |
| 29 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.77039499 |
| 30 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.74417762 |
| 31 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.70212709 |
| 32 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.68045701 |
| 33 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.67310357 |
| 34 | P300_19829295_ChIP-Seq_ESCs_Human | 1.66121922 |
| 35 | * BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.66056238 |
| 36 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.64669179 |
| 37 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.64126495 |
| 38 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.64103366 |
| 39 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.63830763 |
| 40 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.61102487 |
| 41 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.53781823 |
| 42 | VDR_22108803_ChIP-Seq_LS180_Human | 1.51542765 |
| 43 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.48517795 |
| 44 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.47198260 |
| 45 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.47076945 |
| 46 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.46197780 |
| 47 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.46100836 |
| 48 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.45553455 |
| 49 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.44960858 |
| 50 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.43983639 |
| 51 | * RNF2_27304074_Chip-Seq_NSC_Mouse | 1.42154193 |
| 52 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.41372389 |
| 53 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.41229524 |
| 54 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.37785056 |
| 55 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.37429942 |
| 56 | AR_25329375_ChIP-Seq_VCAP_Human | 1.36449306 |
| 57 | STAT3_23295773_ChIP-Seq_U87_Human | 1.36336775 |
| 58 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.32655447 |
| 59 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.30854903 |
| 60 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.29687866 |
| 61 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.29379462 |
| 62 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.25100326 |
| 63 | FUS_26573619_Chip-Seq_HEK293_Human | 1.24974184 |
| 64 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.24638664 |
| 65 | TCF4_23295773_ChIP-Seq_U87_Human | 1.22311459 |
| 66 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.19907946 |
| 67 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.18695791 |
| 68 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.18327190 |
| 69 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.18327190 |
| 70 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.17634008 |
| 71 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.12944819 |
| 72 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.12698719 |
| 73 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.12631073 |
| 74 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.12510762 |
| 75 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.12424777 |
| 76 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.11696417 |
| 77 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.10755137 |
| 78 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.10755137 |
| 79 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.10388221 |
| 80 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.10088579 |
| 81 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.09578695 |
| 82 | KDM2B_26808549_Chip-Seq_REH_Human | 1.08449200 |
| 83 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.07966850 |
| 84 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.06476895 |
| 85 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.06304399 |
| 86 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.06192454 |
| 87 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.05758712 |
| 88 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.05046945 |
| 89 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.04839170 |
| 90 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.04764564 |
| 91 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.04709200 |
| 92 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.04345535 |
| 93 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.03916432 |
| 94 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.03522400 |
| 95 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.03100639 |
| 96 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.03081794 |
| 97 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.02459050 |
| 98 | JUN_21703547_ChIP-Seq_K562_Human | 1.01941415 |
| 99 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.01635628 |
| 100 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.01193432 |
| 101 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.01101108 |
| 102 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.00458534 |
| 103 | TP53_16413492_ChIP-PET_HCT116_Human | 1.00248683 |
| 104 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.00029820 |
| 105 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.99802799 |
| 106 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.99693936 |
| 107 | AR_19668381_ChIP-Seq_PC3_Human | 0.99523640 |
| 108 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.98112736 |
| 109 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.97687103 |
| 110 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.97543792 |
| 111 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.97494170 |
| 112 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.97442493 |
| 113 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.97413300 |
| 114 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.97198289 |
| 115 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.97007649 |
| 116 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.95451916 |
| 117 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.94295746 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.23323481 |
| 2 | MP0003880_abnormal_central_pattern | 4.11531442 |
| 3 | MP0004270_analgesia | 3.90712489 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 3.50642753 |
| 5 | MP0002735_abnormal_chemical_nociception | 3.43303267 |
| 6 | MP0001968_abnormal_touch/_nociception | 3.32731918 |
| 7 | MP0009745_abnormal_behavioral_response | 2.99914062 |
| 8 | MP0002734_abnormal_mechanical_nocicepti | 2.97451537 |
| 9 | MP0002063_abnormal_learning/memory/cond | 2.94655304 |
| 10 | MP0009046_muscle_twitch | 2.84665121 |
| 11 | MP0002736_abnormal_nociception_after | 2.75235899 |
| 12 | MP0001984_abnormal_olfaction | 2.70763810 |
| 13 | MP0002064_seizures | 2.62831274 |
| 14 | MP0002572_abnormal_emotion/affect_behav | 2.59430424 |
| 15 | MP0005410_abnormal_fertilization | 2.58680550 |
| 16 | MP0006276_abnormal_autonomic_nervous | 2.52074507 |
| 17 | MP0001440_abnormal_grooming_behavior | 2.37491659 |
| 18 | MP0002272_abnormal_nervous_system | 2.33827529 |
| 19 | MP0002822_catalepsy | 2.33770866 |
| 20 | MP0002733_abnormal_thermal_nociception | 2.31833903 |
| 21 | MP0001970_abnormal_pain_threshold | 2.20442483 |
| 22 | MP0001501_abnormal_sleep_pattern | 2.15235259 |
| 23 | MP0005423_abnormal_somatic_nervous | 2.08436876 |
| 24 | MP0002184_abnormal_innervation | 2.04411304 |
| 25 | MP0004858_abnormal_nervous_system | 2.00526946 |
| 26 | MP0003121_genomic_imprinting | 2.00362446 |
| 27 | MP0001486_abnormal_startle_reflex | 1.97323148 |
| 28 | MP0002909_abnormal_adrenal_gland | 1.94209283 |
| 29 | MP0002067_abnormal_sensory_capabilities | 1.87765653 |
| 30 | MP0010386_abnormal_urinary_bladder | 1.85098012 |
| 31 | MP0000778_abnormal_nervous_system | 1.83775716 |
| 32 | MP0009780_abnormal_chondrocyte_physiolo | 1.79133083 |
| 33 | MP0003329_amyloid_beta_deposits | 1.74313613 |
| 34 | MP0004133_heterotaxia | 1.70649623 |
| 35 | MP0004924_abnormal_behavior | 1.66827114 |
| 36 | MP0005386_behavior/neurological_phenoty | 1.66827114 |
| 37 | MP0002557_abnormal_social/conspecific_i | 1.64671619 |
| 38 | MP0001905_abnormal_dopamine_level | 1.61616025 |
| 39 | MP0002102_abnormal_ear_morphology | 1.55955072 |
| 40 | MP0005645_abnormal_hypothalamus_physiol | 1.54889013 |
| 41 | MP0004811_abnormal_neuron_physiology | 1.54754882 |
| 42 | MP0005646_abnormal_pituitary_gland | 1.53041135 |
| 43 | MP0001529_abnormal_vocalization | 1.52218376 |
| 44 | MP0003879_abnormal_hair_cell | 1.51724613 |
| 45 | MP0004043_abnormal_pH_regulation | 1.50532917 |
| 46 | MP0001188_hyperpigmentation | 1.47930491 |
| 47 | MP0000955_abnormal_spinal_cord | 1.43698664 |
| 48 | MP0002837_dystrophic_cardiac_calcinosis | 1.41594266 |
| 49 | MP0002876_abnormal_thyroid_physiology | 1.39752963 |
| 50 | MP0002882_abnormal_neuron_morphology | 1.37799732 |
| 51 | MP0008569_lethality_at_weaning | 1.26505465 |
| 52 | MP0002066_abnormal_motor_capabilities/c | 1.25321382 |
| 53 | MP0003698_abnormal_male_reproductive | 1.22682758 |
| 54 | MP0003633_abnormal_nervous_system | 1.18988939 |
| 55 | MP0002234_abnormal_pharynx_morphology | 1.17233131 |
| 56 | MP0005253_abnormal_eye_physiology | 1.13239045 |
| 57 | MP0003787_abnormal_imprinting | 1.09229008 |
| 58 | MP0008877_abnormal_DNA_methylation | 1.07693306 |
| 59 | MP0002229_neurodegeneration | 1.07512564 |
| 60 | MP0001502_abnormal_circadian_rhythm | 1.07166263 |
| 61 | MP0003631_nervous_system_phenotype | 1.03515067 |
| 62 | MP0001986_abnormal_taste_sensitivity | 1.01741067 |
| 63 | MP0005551_abnormal_eye_electrophysiolog | 1.01362860 |
| 64 | MP0002152_abnormal_brain_morphology | 0.97406784 |
| 65 | MP0006292_abnormal_olfactory_placode | 0.96976535 |
| 66 | MP0002928_abnormal_bile_duct | 0.96110394 |
| 67 | MP0003861_abnormal_nervous_system | 0.96057235 |
| 68 | MP0005535_abnormal_body_temperature | 0.95955824 |
| 69 | MP0004145_abnormal_muscle_electrophysio | 0.95226557 |
| 70 | MP0005623_abnormal_meninges_morphology | 0.93954275 |
| 71 | MP0002752_abnormal_somatic_nervous | 0.92680656 |
| 72 | MP0003938_abnormal_ear_development | 0.92270877 |
| 73 | MP0005084_abnormal_gallbladder_morpholo | 0.91733403 |
| 74 | MP0004742_abnormal_vestibular_system | 0.91693337 |
| 75 | MP0002653_abnormal_ependyma_morphology | 0.91198436 |
| 76 | MP0002638_abnormal_pupillary_reflex | 0.91139809 |
| 77 | MP0008789_abnormal_olfactory_epithelium | 0.90274086 |
| 78 | MP0003123_paternal_imprinting | 0.87653401 |
| 79 | MP0001756_abnormal_urination | 0.86985952 |
| 80 | MP0002938_white_spotting | 0.86246804 |
| 81 | MP0001963_abnormal_hearing_physiology | 0.86171947 |
| 82 | MP0008872_abnormal_physiological_respon | 0.85315467 |
| 83 | MP0003937_abnormal_limbs/digits/tail_de | 0.85058940 |
| 84 | MP0002069_abnormal_eating/drinking_beha | 0.84792259 |
| 85 | MP0005499_abnormal_olfactory_system | 0.83889165 |
| 86 | MP0005394_taste/olfaction_phenotype | 0.83889165 |
| 87 | MP0004885_abnormal_endolymph | 0.83567397 |
| 88 | MP0003634_abnormal_glial_cell | 0.83046959 |
| 89 | MP0004215_abnormal_myocardial_fiber | 0.80716615 |
| 90 | MP0005248_abnormal_Harderian_gland | 0.80386931 |
| 91 | MP0003646_muscle_fatigue | 0.80274353 |
| 92 | MP0001299_abnormal_eye_distance/ | 0.80203615 |
| 93 | MP0003122_maternal_imprinting | 0.79595766 |
| 94 | MP0000013_abnormal_adipose_tissue | 0.77745582 |
| 95 | MP0000631_abnormal_neuroendocrine_gland | 0.77666723 |
| 96 | MP0005195_abnormal_posterior_eye | 0.77257848 |
| 97 | MP0004142_abnormal_muscle_tone | 0.76133521 |
| 98 | MP0003119_abnormal_digestive_system | 0.75530137 |
| 99 | MP0002082_postnatal_lethality | 0.75392929 |
| 100 | MP0010770_preweaning_lethality | 0.75392929 |
| 101 | MP0004085_abnormal_heartbeat | 0.74353816 |
| 102 | MP0003632_abnormal_nervous_system | 0.73936853 |
| 103 | MP0001929_abnormal_gametogenesis | 0.72682141 |
| 104 | MP0002090_abnormal_vision | 0.71887038 |
| 105 | MP0010769_abnormal_survival | 0.71479077 |
| 106 | MP0004484_altered_response_of | 0.70961835 |
| 107 | MP0000383_abnormal_hair_follicle | 0.70135126 |
| 108 | MP0008874_decreased_physiological_sensi | 0.69566059 |
| 109 | MP0000604_amyloidosis | 0.69505418 |
| 110 | MP0010768_mortality/aging | 0.68737010 |
| 111 | MP0000516_abnormal_urinary_system | 0.67605149 |
| 112 | MP0005367_renal/urinary_system_phenotyp | 0.67605149 |
| 113 | MP0000538_abnormal_urinary_bladder | 0.65163799 |
| 114 | MP0002751_abnormal_autonomic_nervous | 0.65161647 |
| 115 | MP0005379_endocrine/exocrine_gland_phen | 0.65096109 |
| 116 | MP0001664_abnormal_digestion | 0.64139563 |
| 117 | MP0000751_myopathy | 0.64133363 |
| 118 | MP0001765_abnormal_ion_homeostasis | 0.62856186 |
| 119 | MP0005409_darkened_coat_color | 0.62131298 |
| 120 | MP0006072_abnormal_retinal_apoptosis | 0.62109895 |
| 121 | MP0002160_abnormal_reproductive_system | 0.61703744 |
| 122 | MP0002161_abnormal_fertility/fecundity | 0.61493914 |
| 123 | MP0005187_abnormal_penis_morphology | 0.60301986 |
| 124 | MP0000569_abnormal_digit_pigmentation | 0.56910987 |
| 125 | MP0002163_abnormal_gland_morphology | 0.56256521 |
| 126 | MP0001177_atelectasis | 0.54391085 |
| 127 | MP0001485_abnormal_pinna_reflex | 0.53322381 |
| 128 | MP0000026_abnormal_inner_ear | 0.52074087 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 6.08567339 |
| 2 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 5.82874436 |
| 3 | Myokymia (HP:0002411) | 5.59503158 |
| 4 | Absent/shortened dynein arms (HP:0200106) | 5.12484020 |
| 5 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 5.12484020 |
| 6 | Abnormal respiratory motile cilium physiology (HP:0012261) | 5.03736163 |
| 7 | Abnormal ciliary motility (HP:0012262) | 4.72467341 |
| 8 | Focal seizures (HP:0007359) | 4.45311580 |
| 9 | Visual hallucinations (HP:0002367) | 4.43215577 |
| 10 | Abnormal respiratory motile cilium morphology (HP:0005938) | 4.43127015 |
| 11 | Abnormal respiratory epithelium morphology (HP:0012253) | 4.43127015 |
| 12 | Rhinitis (HP:0012384) | 4.08889925 |
| 13 | Atonic seizures (HP:0010819) | 4.05166953 |
| 14 | Epileptic encephalopathy (HP:0200134) | 3.86517685 |
| 15 | Tubular atrophy (HP:0000092) | 3.67387358 |
| 16 | Progressive cerebellar ataxia (HP:0002073) | 3.61947455 |
| 17 | Absence seizures (HP:0002121) | 3.58992683 |
| 18 | Febrile seizures (HP:0002373) | 3.49976225 |
| 19 | Limb dystonia (HP:0002451) | 3.44350110 |
| 20 | Generalized tonic-clonic seizures (HP:0002069) | 3.27534274 |
| 21 | Dialeptic seizures (HP:0011146) | 3.21636038 |
| 22 | Supranuclear gaze palsy (HP:0000605) | 3.20321525 |
| 23 | Gait imbalance (HP:0002141) | 3.17765924 |
| 24 | Lissencephaly (HP:0001339) | 2.95012989 |
| 25 | Medial flaring of the eyebrow (HP:0010747) | 2.91845958 |
| 26 | Hyperventilation (HP:0002883) | 2.88373285 |
| 27 | True hermaphroditism (HP:0010459) | 2.85640865 |
| 28 | Progressive inability to walk (HP:0002505) | 2.85233266 |
| 29 | Pancreatic fibrosis (HP:0100732) | 2.81314291 |
| 30 | Chronic bronchitis (HP:0004469) | 2.80203061 |
| 31 | Cerebral inclusion bodies (HP:0100314) | 2.78288386 |
| 32 | Pancreatic cysts (HP:0001737) | 2.67188336 |
| 33 | Termporal pattern (HP:0011008) | 2.66663295 |
| 34 | Insidious onset (HP:0003587) | 2.66663295 |
| 35 | Congenital primary aphakia (HP:0007707) | 2.66501102 |
| 36 | Abnormality of the renal medulla (HP:0100957) | 2.65716852 |
| 37 | Broad-based gait (HP:0002136) | 2.65684755 |
| 38 | Action tremor (HP:0002345) | 2.65470109 |
| 39 | Amblyopia (HP:0000646) | 2.65266426 |
| 40 | Infertility (HP:0000789) | 2.63602949 |
| 41 | Type II lissencephaly (HP:0007260) | 2.62705474 |
| 42 | Mutism (HP:0002300) | 2.58575451 |
| 43 | Neurofibrillary tangles (HP:0002185) | 2.56686716 |
| 44 | Gaze-evoked nystagmus (HP:0000640) | 2.56573592 |
| 45 | Tongue fasciculations (HP:0001308) | 2.55044564 |
| 46 | Tubulointerstitial nephritis (HP:0001970) | 2.52340188 |
| 47 | Genital tract atresia (HP:0001827) | 2.44912228 |
| 48 | Hypothermia (HP:0002045) | 2.42836750 |
| 49 | Pachygyria (HP:0001302) | 2.39841961 |
| 50 | Nephrogenic diabetes insipidus (HP:0009806) | 2.39544077 |
| 51 | Abnormality of the corticospinal tract (HP:0002492) | 2.39286876 |
| 52 | Retinal dysplasia (HP:0007973) | 2.38174002 |
| 53 | Pheochromocytoma (HP:0002666) | 2.37246720 |
| 54 | Dysdiadochokinesis (HP:0002075) | 2.36815226 |
| 55 | Ulnar claw (HP:0001178) | 2.34632236 |
| 56 | Vaginal atresia (HP:0000148) | 2.32824408 |
| 57 | Inability to walk (HP:0002540) | 2.32683118 |
| 58 | Drooling (HP:0002307) | 2.32555194 |
| 59 | Excessive salivation (HP:0003781) | 2.32555194 |
| 60 | Ankle clonus (HP:0011448) | 2.32431369 |
| 61 | Truncal ataxia (HP:0002078) | 2.31183769 |
| 62 | Sensorimotor neuropathy (HP:0007141) | 2.29497172 |
| 63 | Cerebellar dysplasia (HP:0007033) | 2.29341502 |
| 64 | Abnormal eating behavior (HP:0100738) | 2.28286690 |
| 65 | Amyotrophic lateral sclerosis (HP:0007354) | 2.28054065 |
| 66 | Postural instability (HP:0002172) | 2.26711467 |
| 67 | Dysmetria (HP:0001310) | 2.25887959 |
| 68 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.24030774 |
| 69 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.24030774 |
| 70 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.23868424 |
| 71 | Nephronophthisis (HP:0000090) | 2.23568758 |
| 72 | Anxiety (HP:0000739) | 2.19293037 |
| 73 | Epileptiform EEG discharges (HP:0011182) | 2.19099794 |
| 74 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.17700008 |
| 75 | Depression (HP:0000716) | 2.17662353 |
| 76 | Abnormality of the lower motor neuron (HP:0002366) | 2.14669584 |
| 77 | Exotropia (HP:0000577) | 2.12738222 |
| 78 | Absent speech (HP:0001344) | 2.11620713 |
| 79 | Hepatoblastoma (HP:0002884) | 2.09133097 |
| 80 | Oligodactyly (hands) (HP:0001180) | 2.08736837 |
| 81 | Neuroendocrine neoplasm (HP:0100634) | 2.08604095 |
| 82 | EEG with generalized epileptiform discharges (HP:0011198) | 2.08547726 |
| 83 | Tubulointerstitial abnormality (HP:0001969) | 2.07787705 |
| 84 | Polyphagia (HP:0002591) | 2.07639454 |
| 85 | Abnormality of the labia minora (HP:0012880) | 2.07433538 |
| 86 | Torticollis (HP:0000473) | 2.05700477 |
| 87 | Muscle fibrillation (HP:0010546) | 2.05400200 |
| 88 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.03698185 |
| 89 | Cystic liver disease (HP:0006706) | 2.02502500 |
| 90 | Bradykinesia (HP:0002067) | 1.97708527 |
| 91 | Chronic hepatic failure (HP:0100626) | 1.96391336 |
| 92 | Spastic tetraplegia (HP:0002510) | 1.96221710 |
| 93 | Akinesia (HP:0002304) | 1.95068677 |
| 94 | Protruding tongue (HP:0010808) | 1.94635878 |
| 95 | Thyroid-stimulating hormone excess (HP:0002925) | 1.94458428 |
| 96 | Hypsarrhythmia (HP:0002521) | 1.94339176 |
| 97 | Muscular hypotonia of the trunk (HP:0008936) | 1.92954463 |
| 98 | Specific learning disability (HP:0001328) | 1.92309427 |
| 99 | Neoplasm of the oral cavity (HP:0100649) | 1.91803135 |
| 100 | Status epilepticus (HP:0002133) | 1.91753746 |
| 101 | Poor coordination (HP:0002370) | 1.90468239 |
| 102 | Hemiparesis (HP:0001269) | 1.89598748 |
| 103 | Poor eye contact (HP:0000817) | 1.89487952 |
| 104 | Postaxial hand polydactyly (HP:0001162) | 1.88839933 |
| 105 | Abnormality of midbrain morphology (HP:0002418) | 1.87921362 |
| 106 | Molar tooth sign on MRI (HP:0002419) | 1.87921362 |
| 107 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.86998828 |
| 108 | Hypoplasia of the brainstem (HP:0002365) | 1.86998828 |
| 109 | Volvulus (HP:0002580) | 1.85675875 |
| 110 | Focal dystonia (HP:0004373) | 1.85598579 |
| 111 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.85284405 |
| 112 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.85284405 |
| 113 | Agitation (HP:0000713) | 1.84992947 |
| 114 | Bronchiectasis (HP:0002110) | 1.84284334 |
| 115 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.84051103 |
| 116 | Hyperthyroidism (HP:0000836) | 1.83603589 |
| 117 | Narrow forehead (HP:0000341) | 1.83231320 |
| 118 | Gastroesophageal reflux (HP:0002020) | 1.83029181 |
| 119 | Abnormal drinking behavior (HP:0030082) | 1.80058125 |
| 120 | Polydipsia (HP:0001959) | 1.80058125 |
| 121 | Papilledema (HP:0001085) | 1.78944265 |
| 122 | Tubulointerstitial fibrosis (HP:0005576) | 1.78878479 |
| 123 | Spastic gait (HP:0002064) | 1.78117808 |
| 124 | Diplopia (HP:0000651) | 1.77600102 |
| 125 | Abnormality of binocular vision (HP:0011514) | 1.77600102 |
| 126 | Fetal akinesia sequence (HP:0001989) | 1.77129782 |
| 127 | Hypokinesia (HP:0002375) | 1.75687531 |
| 128 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.75592686 |
| 129 | Generalized myoclonic seizures (HP:0002123) | 1.75053010 |
| 130 | Urinary urgency (HP:0000012) | 1.74983827 |
| 131 | Delusions (HP:0000746) | 1.74739366 |
| 132 | Genetic anticipation (HP:0003743) | 1.73855088 |
| 133 | Craniofacial dystonia (HP:0012179) | 1.73715424 |
| 134 | Diminished movement (HP:0002374) | 1.73342441 |
| 135 | Hypoventilation (HP:0002791) | 1.71149706 |
| 136 | Gait ataxia (HP:0002066) | 1.71035585 |
| 137 | Impaired social interactions (HP:0000735) | 1.70982882 |
| 138 | Abnormal social behavior (HP:0012433) | 1.70982882 |
| 139 | Short tibia (HP:0005736) | 1.69886472 |
| 140 | Lower limb muscle weakness (HP:0007340) | 1.69847805 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 3.78168301 |
| 2 | MARK1 | 3.29986836 |
| 3 | MAP3K9 | 3.26047785 |
| 4 | MAP3K4 | 3.16325984 |
| 5 | EPHA4 | 3.06194588 |
| 6 | MAP2K7 | 2.69428462 |
| 7 | MINK1 | 2.42234685 |
| 8 | PNCK | 2.40251135 |
| 9 | CASK | 2.39927143 |
| 10 | MAP3K12 | 2.37319071 |
| 11 | PDK3 | 2.24092455 |
| 12 | PDK4 | 2.24092455 |
| 13 | GRK5 | 2.14042431 |
| 14 | NTRK1 | 2.11017973 |
| 15 | MAP4K2 | 2.10529446 |
| 16 | RIPK4 | 2.05991093 |
| 17 | MAP2K4 | 2.02283679 |
| 18 | PRKD3 | 2.00346726 |
| 19 | DAPK2 | 1.89294648 |
| 20 | KSR2 | 1.74142830 |
| 21 | PHKG2 | 1.73185911 |
| 22 | PHKG1 | 1.73185911 |
| 23 | TRIM28 | 1.70460759 |
| 24 | PLK2 | 1.68148041 |
| 25 | LATS2 | 1.57749036 |
| 26 | CAMKK2 | 1.57161810 |
| 27 | PAK6 | 1.54980749 |
| 28 | MAP3K2 | 1.54167962 |
| 29 | NTRK2 | 1.47159609 |
| 30 | PRPF4B | 1.45797970 |
| 31 | ARAF | 1.39362526 |
| 32 | MAPK13 | 1.32263114 |
| 33 | PTK2B | 1.31812182 |
| 34 | CSNK1G1 | 1.26646388 |
| 35 | PDK2 | 1.26104903 |
| 36 | CAMKK1 | 1.23333766 |
| 37 | CDK5 | 1.22990351 |
| 38 | WNK4 | 1.20827158 |
| 39 | KSR1 | 1.20416801 |
| 40 | PRKCG | 1.17572630 |
| 41 | DAPK1 | 1.16452177 |
| 42 | STK39 | 1.11746843 |
| 43 | AKT3 | 1.11650892 |
| 44 | CAMK2A | 1.10064777 |
| 45 | CSNK1G2 | 1.09733699 |
| 46 | NUAK1 | 1.08681509 |
| 47 | INSRR | 1.06482168 |
| 48 | STK38 | 1.06472303 |
| 49 | PASK | 0.99168716 |
| 50 | CAMK2B | 0.96703897 |
| 51 | BMPR1B | 0.96255246 |
| 52 | WNK3 | 0.94062020 |
| 53 | GRK7 | 0.92736488 |
| 54 | TESK1 | 0.92338137 |
| 55 | BMPR2 | 0.82280792 |
| 56 | PKN1 | 0.81886521 |
| 57 | LIMK1 | 0.81481991 |
| 58 | EPHA3 | 0.81098027 |
| 59 | DYRK3 | 0.81019010 |
| 60 | FER | 0.79732352 |
| 61 | SIK2 | 0.76073303 |
| 62 | RET | 0.75222426 |
| 63 | LMTK2 | 0.73061335 |
| 64 | PAK3 | 0.72592928 |
| 65 | PRKCE | 0.70129837 |
| 66 | STK11 | 0.69363915 |
| 67 | TAOK2 | 0.68707005 |
| 68 | WNK1 | 0.68011687 |
| 69 | CDK14 | 0.67311514 |
| 70 | OXSR1 | 0.67286414 |
| 71 | SGK223 | 0.65806636 |
| 72 | SGK494 | 0.65806636 |
| 73 | PINK1 | 0.65016228 |
| 74 | GRK1 | 0.64614208 |
| 75 | NME1 | 0.64114997 |
| 76 | CAMK2D | 0.63448765 |
| 77 | CSNK1G3 | 0.63394506 |
| 78 | FRK | 0.63262545 |
| 79 | MAP3K1 | 0.61938972 |
| 80 | CDK18 | 0.59217347 |
| 81 | BRAF | 0.57226337 |
| 82 | MKNK2 | 0.56911511 |
| 83 | PRKG1 | 0.56770884 |
| 84 | PDPK1 | 0.56030788 |
| 85 | CDK15 | 0.55561056 |
| 86 | CAMK4 | 0.54887274 |
| 87 | CSNK1D | 0.54346131 |
| 88 | TYRO3 | 0.53900887 |
| 89 | DYRK1A | 0.53122523 |
| 90 | MAPK15 | 0.52847237 |
| 91 | BCR | 0.52674732 |
| 92 | SGK2 | 0.52575010 |
| 93 | PRKCZ | 0.52207514 |
| 94 | TLK1 | 0.50996166 |
| 95 | PRKACA | 0.50780354 |
| 96 | PDK1 | 0.50705958 |
| 97 | CAMK2G | 0.50594236 |
| 98 | MAP2K1 | 0.49594414 |
| 99 | CSNK1E | 0.49241893 |
| 100 | CDK3 | 0.48513097 |
| 101 | FGFR2 | 0.48143680 |
| 102 | CSNK1A1 | 0.47668548 |
| 103 | FGR | 0.47302881 |
| 104 | TSSK6 | 0.46244748 |
| 105 | ERBB3 | 0.45967971 |
| 106 | TNIK | 0.45738914 |
| 107 | PRKACB | 0.44978780 |
| 108 | DYRK2 | 0.44352331 |
| 109 | CDK11A | 0.43673130 |
| 110 | ADRBK1 | 0.42856848 |
| 111 | SGK1 | 0.42467524 |
| 112 | FES | 0.42268784 |
| 113 | CAMK1G | 0.42061323 |
| 114 | PRKCH | 0.40303632 |
| 115 | TAOK1 | 0.39826098 |
| 116 | UHMK1 | 0.39775237 |
| 117 | ICK | 0.39406444 |
| 118 | CSNK1A1L | 0.38515567 |
| 119 | MARK2 | 0.38313513 |
| 120 | CAMK1 | 0.38204026 |
| 121 | RPS6KA3 | 0.38042789 |
| 122 | RPS6KA2 | 0.37913295 |
| 123 | CCNB1 | 0.37363997 |
| 124 | CDK19 | 0.36451031 |
| 125 | ADRBK2 | 0.34965604 |
| 126 | TNK2 | 0.34801541 |
| 127 | PRKCA | 0.33424598 |
| 128 | EPHB2 | 0.30117527 |
| 129 | PRKAA1 | 0.29143070 |
| 130 | PRKCB | 0.28537511 |
| 131 | ERBB2 | 0.28270649 |
| 132 | PRKACG | 0.27464361 |
| 133 | LATS1 | 0.26895986 |
| 134 | BCKDK | 0.26543253 |
| 135 | ROCK2 | 0.24910320 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.31704675 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.21519614 |
| 3 | Olfactory transduction_Homo sapiens_hsa04740 | 3.17281174 |
| 4 | Long-term potentiation_Homo sapiens_hsa04720 | 2.64245994 |
| 5 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.60283602 |
| 6 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.43102851 |
| 7 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.36754960 |
| 8 | Circadian entrainment_Homo sapiens_hsa04713 | 2.36617212 |
| 9 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.26040739 |
| 10 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.21453015 |
| 11 | GABAergic synapse_Homo sapiens_hsa04727 | 2.21034614 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.19435070 |
| 13 | Morphine addiction_Homo sapiens_hsa05032 | 2.16918626 |
| 14 | Taste transduction_Homo sapiens_hsa04742 | 2.09765161 |
| 15 | Insulin secretion_Homo sapiens_hsa04911 | 2.06057827 |
| 16 | Salivary secretion_Homo sapiens_hsa04970 | 1.99840994 |
| 17 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.97891960 |
| 18 | Renin secretion_Homo sapiens_hsa04924 | 1.92602912 |
| 19 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.89113464 |
| 20 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.87565276 |
| 21 | Protein export_Homo sapiens_hsa03060 | 1.85452487 |
| 22 | Cocaine addiction_Homo sapiens_hsa05030 | 1.71896730 |
| 23 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.71531718 |
| 24 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.61787224 |
| 25 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.54122717 |
| 26 | Long-term depression_Homo sapiens_hsa04730 | 1.52374003 |
| 27 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.52136049 |
| 28 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.39310692 |
| 29 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.34934849 |
| 30 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.34424230 |
| 31 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.32923002 |
| 32 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.30585661 |
| 33 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.27073325 |
| 34 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.24536621 |
| 35 | Phototransduction_Homo sapiens_hsa04744 | 1.23486035 |
| 36 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.19377661 |
| 37 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.16525197 |
| 38 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.15677429 |
| 39 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.14435078 |
| 40 | Gap junction_Homo sapiens_hsa04540 | 1.14139572 |
| 41 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.13477642 |
| 42 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.12485395 |
| 43 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.12290675 |
| 44 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.10989718 |
| 45 | Axon guidance_Homo sapiens_hsa04360 | 1.09076372 |
| 46 | Alzheimers disease_Homo sapiens_hsa05010 | 1.06700934 |
| 47 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.05901322 |
| 48 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.05865236 |
| 49 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.04034408 |
| 50 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.03808545 |
| 51 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.03541971 |
| 52 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.02745616 |
| 53 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.99657871 |
| 54 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.98305363 |
| 55 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.96243590 |
| 56 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.95589460 |
| 57 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.95291440 |
| 58 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.93846123 |
| 59 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.87757018 |
| 60 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.87136936 |
| 61 | Glioma_Homo sapiens_hsa05214 | 0.87065274 |
| 62 | Melanogenesis_Homo sapiens_hsa04916 | 0.86556070 |
| 63 | Basal transcription factors_Homo sapiens_hsa03022 | 0.84768673 |
| 64 | Huntingtons disease_Homo sapiens_hsa05016 | 0.83534006 |
| 65 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.81651552 |
| 66 | Parkinsons disease_Homo sapiens_hsa05012 | 0.81564696 |
| 67 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.80794802 |
| 68 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.79587449 |
| 69 | Peroxisome_Homo sapiens_hsa04146 | 0.79100225 |
| 70 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.76001205 |
| 71 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.75444627 |
| 72 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.75113671 |
| 73 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.71847545 |
| 74 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.69490072 |
| 75 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.68245116 |
| 76 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.67832162 |
| 77 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.67477901 |
| 78 | Tight junction_Homo sapiens_hsa04530 | 0.64461156 |
| 79 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.63691991 |
| 80 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.63239703 |
| 81 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.61904804 |
| 82 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.61323927 |
| 83 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.61232964 |
| 84 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.61198485 |
| 85 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.60015491 |
| 86 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.59302128 |
| 87 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.58866899 |
| 88 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.58299713 |
| 89 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.57623786 |
| 90 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.56902065 |
| 91 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.56298279 |
| 92 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.55329426 |
| 93 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.54451877 |
| 94 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.52130924 |
| 95 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.51506486 |
| 96 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.50145190 |
| 97 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.49901180 |
| 98 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.48827163 |
| 99 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.47439556 |
| 100 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.47183477 |
| 101 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.46921426 |
| 102 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.46888054 |
| 103 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.45751215 |
| 104 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.45383281 |
| 105 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.45381369 |
| 106 | Circadian rhythm_Homo sapiens_hsa04710 | 0.45210298 |
| 107 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.45038912 |
| 108 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.44172300 |
| 109 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.43464175 |
| 110 | Endometrial cancer_Homo sapiens_hsa05213 | 0.43290634 |
| 111 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.43211826 |
| 112 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.42218771 |
| 113 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.42077599 |
| 114 | Mineral absorption_Homo sapiens_hsa04978 | 0.41500017 |
| 115 | Alcoholism_Homo sapiens_hsa05034 | 0.41233214 |
| 116 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.40360978 |
| 117 | Bile secretion_Homo sapiens_hsa04976 | 0.40132897 |
| 118 | Phagosome_Homo sapiens_hsa04145 | 0.39520932 |
| 119 | Prion diseases_Homo sapiens_hsa05020 | 0.39402416 |
| 120 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.39338512 |
| 121 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.38017640 |
| 122 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.37701455 |
| 123 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.37700905 |
| 124 | Endocytosis_Homo sapiens_hsa04144 | 0.36912662 |
| 125 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.36464748 |
| 126 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.36373521 |
| 127 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.36164615 |
| 128 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.36146662 |
| 129 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.36094843 |
| 130 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.35176060 |
| 131 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.34758945 |
| 132 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.32676944 |
| 133 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.32491382 |
| 134 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.31900226 |
| 135 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.31786709 |
| 136 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.30983798 |
| 137 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.30255132 |
| 138 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.25928135 |

