CDKL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.81162607
2cilium or flagellum-dependent cell motility (GO:0001539)9.71358029
3axonemal dynein complex assembly (GO:0070286)9.28722569
4sperm motility (GO:0030317)9.01163723
5fusion of sperm to egg plasma membrane (GO:0007342)9.00604289
6cilium movement (GO:0003341)8.71843768
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.51161505
8acrosome reaction (GO:0007340)8.04529272
9multicellular organism reproduction (GO:0032504)7.94200869
10regulation of cilium movement (GO:0003352)7.86232787
11motile cilium assembly (GO:0044458)7.57726555
12cell wall macromolecule catabolic process (GO:0016998)7.53595533
13cell wall macromolecule metabolic process (GO:0044036)7.53595533
14sperm-egg recognition (GO:0035036)7.48601046
15acrosome assembly (GO:0001675)7.42448371
16plasma membrane fusion (GO:0045026)6.85136509
17binding of sperm to zona pellucida (GO:0007339)6.63463793
18cell-cell recognition (GO:0009988)6.52869285
19spermatid development (GO:0007286)6.37518646
20reproduction (GO:0000003)6.27794176
21piRNA metabolic process (GO:0034587)6.25405334
22male meiosis (GO:0007140)5.54219622
23single fertilization (GO:0007338)5.46574141
24sperm capacitation (GO:0048240)5.25890861
25ventricular system development (GO:0021591)5.10939164
26synaptonemal complex organization (GO:0070193)5.05716384
27axoneme assembly (GO:0035082)5.03631545
28fertilization (GO:0009566)4.81166145
29proline biosynthetic process (GO:0006561)4.77305145
30regulation of microtubule-based movement (GO:0060632)4.63840366
31spermatogenesis (GO:0007283)4.56989330
32male gamete generation (GO:0048232)4.55501381
33intraciliary transport (GO:0042073)4.51868591
34microtubule depolymerization (GO:0007019)4.50909093
35synaptonemal complex assembly (GO:0007130)4.47261467
36behavioral response to nicotine (GO:0035095)4.42581882
37DNA methylation involved in gamete generation (GO:0043046)4.29865149
38gamete generation (GO:0007276)4.26255180
39transcription from mitochondrial promoter (GO:0006390)4.25402996
40single strand break repair (GO:0000012)4.21182598
41neural tube formation (GO:0001841)4.13890030
42germ cell development (GO:0007281)3.96956864
43calcium ion-dependent exocytosis (GO:0017156)3.95803092
44protein polyglutamylation (GO:0018095)3.89749213
45replication fork processing (GO:0031297)3.89303267
46microtubule severing (GO:0051013)3.74980641
47cellular process involved in reproduction in multicellular organism (GO:0022412)3.73490925
48protein complex biogenesis (GO:0070271)3.70652100
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.69192826
50protein localization to cilium (GO:0061512)3.62328522
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.62224468
52cellular ketone body metabolic process (GO:0046950)3.61628861
53negative regulation of inclusion body assembly (GO:0090084)3.61012648
54poly(A)+ mRNA export from nucleus (GO:0016973)3.58975796
55cell recognition (GO:0008037)3.58872769
56male meiosis I (GO:0007141)3.52155301
57left/right pattern formation (GO:0060972)3.51159168
58proline metabolic process (GO:0006560)3.49837627
59DNA strand renaturation (GO:0000733)3.48262528
60mitochondrial respiratory chain complex I assembly (GO:0032981)3.47475062
61NADH dehydrogenase complex assembly (GO:0010257)3.47475062
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47475062
63DNA double-strand break processing (GO:0000729)3.45017132
64mitochondrial respiratory chain complex assembly (GO:0033108)3.41413063
65glycerol ether metabolic process (GO:0006662)3.41308690
66cilium organization (GO:0044782)3.39191002
67DNA deamination (GO:0045006)3.35544176
68multicellular organismal reproductive process (GO:0048609)3.34462959
69cilium assembly (GO:0042384)3.32626188
70regulation of spindle checkpoint (GO:0090231)3.32150381
71organic cation transport (GO:0015695)3.29324676
72chromosome organization involved in meiosis (GO:0070192)3.29284961
73meiotic nuclear division (GO:0007126)3.28442001
74ketone body metabolic process (GO:1902224)3.27538905
75ether metabolic process (GO:0018904)3.25643893
76nonmotile primary cilium assembly (GO:0035058)3.23918359
77L-fucose catabolic process (GO:0042355)3.23608394
78fucose catabolic process (GO:0019317)3.23608394
79L-fucose metabolic process (GO:0042354)3.23608394
80positive regulation of protein homooligomerization (GO:0032464)3.22045021
81GTP biosynthetic process (GO:0006183)3.21345504
82cellular response to ATP (GO:0071318)3.21142392
83spermatid nucleus differentiation (GO:0007289)3.21111247
84regulation of inclusion body assembly (GO:0090083)3.17956423
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17796113
86mannosylation (GO:0097502)3.15384736
87indole-containing compound catabolic process (GO:0042436)3.14327481
88indolalkylamine catabolic process (GO:0046218)3.14327481
89tryptophan catabolic process (GO:0006569)3.14327481
90microtubule-based movement (GO:0007018)3.12577429
91nucleoside diphosphate phosphorylation (GO:0006165)3.12046788
92indolalkylamine metabolic process (GO:0006586)3.11685257
93postsynaptic membrane organization (GO:0001941)3.05724850
94pyrimidine nucleobase catabolic process (GO:0006208)3.04118072
95regulation of meiosis I (GO:0060631)3.00905156
96photoreceptor cell maintenance (GO:0045494)2.99612075
97protein neddylation (GO:0045116)2.99304670
98response to pheromone (GO:0019236)2.98917389
99cilium morphogenesis (GO:0060271)2.98303591
100negative regulation of transcription regulatory region DNA binding (GO:2000678)2.97375229
101somite development (GO:0061053)2.97014461
102maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95738041
103respiratory chain complex IV assembly (GO:0008535)2.95571433
104centriole replication (GO:0007099)2.95439317
105cellular component assembly involved in morphogenesis (GO:0010927)2.95415905
106meiotic cell cycle (GO:0051321)2.93670772
107synaptic transmission, cholinergic (GO:0007271)2.91705713
108limb bud formation (GO:0060174)2.91477159
109presynaptic membrane assembly (GO:0097105)2.88796289
110behavioral response to ethanol (GO:0048149)2.87966880
111oxidative demethylation (GO:0070989)2.85983770
112reciprocal DNA recombination (GO:0035825)2.84979399
113reciprocal meiotic recombination (GO:0007131)2.84979399
114platelet dense granule organization (GO:0060155)2.83616656
115positive regulation of oligodendrocyte differentiation (GO:0048714)2.83586630
116transmission of nerve impulse (GO:0019226)2.82561382
117auditory receptor cell stereocilium organization (GO:0060088)2.82363702
118inner ear receptor stereocilium organization (GO:0060122)2.81706161
119adaptation of signaling pathway (GO:0023058)2.79935871
120L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79240383
121UTP biosynthetic process (GO:0006228)2.77694448
122mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77053254
123neuron fate determination (GO:0048664)2.76827291
124centriole assembly (GO:0098534)2.74624409
125kynurenine metabolic process (GO:0070189)2.73877328
126sex differentiation (GO:0007548)2.73776379
127regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71227226
128multicellular organismal development (GO:0007275)2.70787310
129left/right axis specification (GO:0070986)2.70032504
130ubiquinone metabolic process (GO:0006743)2.69710590
131tryptophan metabolic process (GO:0006568)2.68901778
132establishment of protein localization to Golgi (GO:0072600)2.68443011
133neuron cell-cell adhesion (GO:0007158)2.68434097
134C4-dicarboxylate transport (GO:0015740)2.67266370
135cytochrome complex assembly (GO:0017004)2.63708297
136regulation of podosome assembly (GO:0071801)2.63536513
137dopamine transport (GO:0015872)2.63304645
138preassembly of GPI anchor in ER membrane (GO:0016254)2.63185201
139sympathetic nervous system development (GO:0048485)2.62064082
140seminiferous tubule development (GO:0072520)2.61479556
141water-soluble vitamin biosynthetic process (GO:0042364)2.60676497
142cellular biogenic amine catabolic process (GO:0042402)2.60027029
143amine catabolic process (GO:0009310)2.60027029
144signal peptide processing (GO:0006465)2.59127946
145negative regulation of mast cell activation (GO:0033004)2.58379715
146mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.57896254
147ubiquinone biosynthetic process (GO:0006744)2.57016821
148regulation of protein homooligomerization (GO:0032462)2.56945522
149establishment of monopolar cell polarity (GO:0061162)2.56621633
150establishment or maintenance of monopolar cell polarity (GO:0061339)2.56621633
151somatic hypermutation of immunoglobulin genes (GO:0016446)2.56355179
152somatic diversification of immune receptors via somatic mutation (GO:0002566)2.56355179
153establishment of apical/basal cell polarity (GO:0035089)2.55930190
154meiosis I (GO:0007127)2.55335665
155presynaptic membrane organization (GO:0097090)2.53541391
156glial cell migration (GO:0008347)2.52860850
157mRNA polyadenylation (GO:0006378)2.52804908
158genitalia morphogenesis (GO:0035112)2.52288363
159resolution of meiotic recombination intermediates (GO:0000712)2.52256800
160nucleobase catabolic process (GO:0046113)2.52241564
161indole-containing compound metabolic process (GO:0042430)2.52234518
162negative regulation of heart rate (GO:0010459)2.51867171
163synaptic vesicle endocytosis (GO:0048488)2.51832012
164photoreceptor cell development (GO:0042461)2.50754174
165gamma-aminobutyric acid transport (GO:0015812)2.49987927
166detection of light stimulus involved in sensory perception (GO:0050962)2.49504841
167detection of light stimulus involved in visual perception (GO:0050908)2.49504841
168positive regulation of mitochondrial fission (GO:0090141)2.46530816
169GPI anchor metabolic process (GO:0006505)2.45670013
170neuronal action potential (GO:0019228)2.45566857
171retinal ganglion cell axon guidance (GO:0031290)2.43916858
172L-methionine biosynthetic process (GO:0071265)2.43787663

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.51935486
2EZH2_22144423_ChIP-Seq_EOC_Human4.91686911
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.14609593
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.98483458
5IGF1R_20145208_ChIP-Seq_DFB_Human2.77345265
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.73057782
7VDR_22108803_ChIP-Seq_LS180_Human2.61938402
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.48472922
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47961883
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.28105820
11P300_19829295_ChIP-Seq_ESCs_Human2.15852202
12RNF2_27304074_Chip-Seq_NSC_Mouse2.07329842
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.01722447
14EWS_26573619_Chip-Seq_HEK293_Human2.01610364
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98618515
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98357827
17ER_23166858_ChIP-Seq_MCF-7_Human1.98156845
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96207361
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.93936713
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90549210
21REST_21632747_ChIP-Seq_MESCs_Mouse1.88392936
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85834573
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85792301
24* GABP_17652178_ChIP-ChIP_JURKAT_Human1.75558851
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72855778
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71897954
27GBX2_23144817_ChIP-Seq_PC3_Human1.70603456
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.67468526
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.66210400
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64941937
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64923382
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62661143
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62095546
34CBP_20019798_ChIP-Seq_JUKART_Human1.62095546
35BCAT_22108803_ChIP-Seq_LS180_Human1.60614784
36KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.60568815
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60275068
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59611785
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58338688
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57130020
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55946026
42STAT3_23295773_ChIP-Seq_U87_Human1.55926987
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55215521
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54764178
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.53426544
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.52950136
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.52351958
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52157023
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.48472265
50AR_25329375_ChIP-Seq_VCAP_Human1.47911163
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47459441
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47390366
53P300_18555785_Chip-Seq_ESCs_Mouse1.44763622
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44380048
55ELK1_19687146_ChIP-ChIP_HELA_Human1.44065995
56IRF1_19129219_ChIP-ChIP_H3396_Human1.43922020
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43763536
58WDR5_24793694_ChIP-Seq_LNCAP_Human1.42720389
59STAT3_18555785_Chip-Seq_ESCs_Mouse1.42643165
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42121779
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42121779
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41597876
63FUS_26573619_Chip-Seq_HEK293_Human1.41576949
64TP53_22573176_ChIP-Seq_HFKS_Human1.40816204
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.40513971
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39314666
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.38237215
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38142639
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37900130
70SOX2_19829295_ChIP-Seq_ESCs_Human1.37782924
71NANOG_19829295_ChIP-Seq_ESCs_Human1.37782924
72TAL1_26923725_Chip-Seq_HPCs_Mouse1.37518227
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37218728
74KLF4_18555785_Chip-Seq_ESCs_Mouse1.36867709
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.36642015
76ZNF274_21170338_ChIP-Seq_K562_Hela1.36216149
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.36166487
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35803080
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35093009
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34371208
81* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33861504
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.33441730
83P53_22387025_ChIP-Seq_ESCs_Mouse1.33212473
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32676181
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32195954
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31235524
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29100043
88TCF4_22108803_ChIP-Seq_LS180_Human1.28796770
89* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28075210
90RUNX2_22187159_ChIP-Seq_PCA_Human1.26509408
91ESRRB_18555785_Chip-Seq_ESCs_Mouse1.26340548
92SOX2_18555785_Chip-Seq_ESCs_Mouse1.25257452
93ELK4_26923725_Chip-Seq_MESODERM_Mouse1.23952053
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23129150
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22882327
96MYC_18940864_ChIP-ChIP_HL60_Human1.20113097
97NMYC_18555785_Chip-Seq_ESCs_Mouse1.19057518
98KDM2B_26808549_Chip-Seq_REH_Human1.19051170
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18873008
100CTCF_18555785_Chip-Seq_ESCs_Mouse1.18199158
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17388870
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16202049
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.15516367
104STAT3_18555785_ChIP-Seq_MESCs_Mouse1.14822044
105ZFX_18555785_Chip-Seq_ESCs_Mouse1.13448826
106* FLI1_21867929_ChIP-Seq_TH2_Mouse1.13365197
107TBL1_22424771_ChIP-Seq_293T_Human1.12130198
108RUNX1_27457419_Chip-Seq_LIVER_Mouse1.11581077
109SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11388862
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11095919
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.11095919
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10505574
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.10167670
114AR_21572438_ChIP-Seq_LNCaP_Human1.09681223
115SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09222442
116* CRX_20693478_ChIP-Seq_RETINA_Mouse1.07905452
117NFYB_21822215_ChIP-Seq_K562_Human1.07332407
118TAF15_26573619_Chip-Seq_HEK293_Human1.06540079
119* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05781550
120ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05116433
121VDR_23849224_ChIP-Seq_CD4+_Human1.04694858
122* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04349906
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04311139
124SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04135750
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.03939103
126NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03851236
127PU1_27457419_Chip-Seq_LIVER_Mouse1.03646768
128CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03556612
129SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.02620367
130POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02344258
131* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02300747
132TCF4_23295773_ChIP-Seq_U87_Human1.01830717
133GATA3_21867929_ChIP-Seq_TH1_Mouse0.99249424
134* SOX9_26525672_Chip-Seq_HEART_Mouse0.98895513
135SALL1_21062744_ChIP-ChIP_HESCs_Human0.98431610
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98409492
137NCOR_22424771_ChIP-Seq_293T_Human0.97669991
138RNF2_27304074_Chip-Seq_ESCs_Mouse0.97347016
139AR_20517297_ChIP-Seq_VCAP_Human0.97317014
140* SPI1_26923725_Chip-Seq_HPCs_Mouse0.97280714
141REST_18959480_ChIP-ChIP_MESCs_Mouse0.97122050
142NOTCH1_21737748_ChIP-Seq_TLL_Human0.97063883
143FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96868362
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96415448
145AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96200439
146* GF1_26923725_Chip-Seq_HPCs_Mouse0.95873087
147* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95737660
148CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95535331
149* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95335408
150ETV1_20927104_ChIP-Seq_GIST48_Human0.95295918
151PHF8_20622853_ChIP-Seq_HELA_Human0.94751869
152EZH2_27304074_Chip-Seq_ESCs_Mouse0.94551315
153FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93079203
154STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92200808
155* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91870306
156POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91851095
157NFYA_21822215_ChIP-Seq_K562_Human0.91297295
158* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91081887
159SMAD4_21799915_ChIP-Seq_A2780_Human0.90659753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.92359009
2MP0008057_abnormal_DNA_replication3.94735854
3MP0008877_abnormal_DNA_methylation3.72965692
4MP0003698_abnormal_male_reproductive3.70298384
5MP0005171_absent_coat_pigmentation3.34943618
6MP0001929_abnormal_gametogenesis3.28102200
7MP0002837_dystrophic_cardiac_calcinosis2.90019630
8MP0002653_abnormal_ependyma_morphology2.53942043
9MP0002210_abnormal_sex_determination2.32693513
10MP0008995_early_reproductive_senescence2.32543609
11MP0002009_preneoplasia2.16305902
12MP0006072_abnormal_retinal_apoptosis2.07798077
13MP0001986_abnormal_taste_sensitivity2.03528517
14MP0002234_abnormal_pharynx_morphology1.99084299
15MP0001145_abnormal_male_reproductive1.98423452
16MP0000569_abnormal_digit_pigmentation1.98269383
17MP0002161_abnormal_fertility/fecundity1.97963520
18MP0005645_abnormal_hypothalamus_physiol1.87615815
19MP0001485_abnormal_pinna_reflex1.86564799
20MP0009046_muscle_twitch1.83846718
21MP0004147_increased_porphyrin_level1.83351308
22MP0004233_abnormal_muscle_weight1.81397044
23MP0003195_calcinosis1.77441318
24MP0004133_heterotaxia1.74071116
25MP0002282_abnormal_trachea_morphology1.71835971
26MP0000372_irregular_coat_pigmentation1.71756712
27MP0000653_abnormal_sex_gland1.67651921
28MP0001984_abnormal_olfaction1.65592740
29MP0009278_abnormal_bone_marrow1.61620611
30MP0003880_abnormal_central_pattern1.58408619
31MP0004885_abnormal_endolymph1.56798789
32MP0003136_yellow_coat_color1.55259561
33MP0008058_abnormal_DNA_repair1.54865454
34MP0005646_abnormal_pituitary_gland1.52259535
35MP0005174_abnormal_tail_pigmentation1.49515106
36MP0005253_abnormal_eye_physiology1.48955254
37MP0000015_abnormal_ear_pigmentation1.46590928
38MP0005551_abnormal_eye_electrophysiolog1.46546272
39MP0005623_abnormal_meninges_morphology1.42673944
40MP0004142_abnormal_muscle_tone1.42371654
41MP0002572_abnormal_emotion/affect_behav1.39539339
42MP0008789_abnormal_olfactory_epithelium1.37689833
43MP0003122_maternal_imprinting1.36632189
44MP0001529_abnormal_vocalization1.34752427
45MP0006292_abnormal_olfactory_placode1.33101734
46MP0000778_abnormal_nervous_system1.30659458
47MP0002163_abnormal_gland_morphology1.29587117
48MP0002160_abnormal_reproductive_system1.27415486
49MP0003121_genomic_imprinting1.26448664
50MP0001502_abnormal_circadian_rhythm1.23118983
51MP0003890_abnormal_embryonic-extraembry1.22340954
52MP0003786_premature_aging1.20235242
53MP0003011_delayed_dark_adaptation1.19537859
54MP0010030_abnormal_orbit_morphology1.18205742
55MP0002063_abnormal_learning/memory/cond1.16557285
56MP0002102_abnormal_ear_morphology1.15017289
57MP0006276_abnormal_autonomic_nervous1.14642050
58MP0000427_abnormal_hair_cycle1.13602936
59MP0008872_abnormal_physiological_respon1.13513686
60MP0005394_taste/olfaction_phenotype1.12909576
61MP0005499_abnormal_olfactory_system1.12909576
62MP0002734_abnormal_mechanical_nocicepti1.12827994
63MP0002095_abnormal_skin_pigmentation1.10405821
64MP0005423_abnormal_somatic_nervous1.09820083
65MP0010386_abnormal_urinary_bladder1.06686439
66MP0004134_abnormal_chest_morphology1.06559444
67MP0001440_abnormal_grooming_behavior1.06276533
68MP0003283_abnormal_digestive_organ1.05548008
69MP0003646_muscle_fatigue1.04022395
70MP0002736_abnormal_nociception_after1.03886297
71MP0001501_abnormal_sleep_pattern1.02884581
72MP0001324_abnormal_eye_pigmentation1.00466651
73MP0004270_analgesia0.99857206
74MP0002928_abnormal_bile_duct0.99382104
75MP0003718_maternal_effect0.98956298
76MP0002229_neurodegeneration0.97857207
77MP0001486_abnormal_startle_reflex0.97716882
78MP0002272_abnormal_nervous_system0.97570359
79MP0000049_abnormal_middle_ear0.95243683
80MP0005670_abnormal_white_adipose0.94577821
81MP0004145_abnormal_muscle_electrophysio0.94284069
82MP0001968_abnormal_touch/_nociception0.94140224
83MP0010094_abnormal_chromosome_stability0.93101591
84MP0004043_abnormal_pH_regulation0.92150585
85MP0005386_behavior/neurological_phenoty0.91550555
86MP0004924_abnormal_behavior0.91550555
87MP0008875_abnormal_xenobiotic_pharmacok0.91465055
88MP0000647_abnormal_sebaceous_gland0.91096407
89MP0004742_abnormal_vestibular_system0.90911312
90MP0003635_abnormal_synaptic_transmissio0.89443377
91MP0002249_abnormal_larynx_morphology0.88418935
92MP0002064_seizures0.87532620
93MP0002067_abnormal_sensory_capabilities0.87462532
94MP0005084_abnormal_gallbladder_morpholo0.87202876
95MP0001293_anophthalmia0.86787415
96MP0005389_reproductive_system_phenotype0.86559965
97MP0000026_abnormal_inner_ear0.86135880
98MP0005187_abnormal_penis_morphology0.85545855
99MP0000462_abnormal_digestive_system0.85530584
100MP0009745_abnormal_behavioral_response0.82556854
101MP0000631_abnormal_neuroendocrine_gland0.82539837
102MP0005391_vision/eye_phenotype0.81915999
103MP0002752_abnormal_somatic_nervous0.81206590
104MP0003878_abnormal_ear_physiology0.81181501
105MP0005377_hearing/vestibular/ear_phenot0.81181501
106MP0003137_abnormal_impulse_conducting0.81148078
107MP0002822_catalepsy0.80820289
108MP0002735_abnormal_chemical_nociception0.80650619
109MP0001970_abnormal_pain_threshold0.80538762
110MP0000955_abnormal_spinal_cord0.80530609
111MP0005195_abnormal_posterior_eye0.80063810
112MP0003119_abnormal_digestive_system0.78200084
113MP0005075_abnormal_melanosome_morpholog0.77909935
114MP0002184_abnormal_innervation0.77252536
115MP0002882_abnormal_neuron_morphology0.77061635
116MP0002557_abnormal_social/conspecific_i0.76190217
117MP0002116_abnormal_craniofacial_bone0.76020867
118MP0005379_endocrine/exocrine_gland_phen0.75766502
119MP0002938_white_spotting0.74811137
120MP0001188_hyperpigmentation0.73242676
121MP0001905_abnormal_dopamine_level0.72729904
122MP0001963_abnormal_hearing_physiology0.72445781
123MP0002152_abnormal_brain_morphology0.69939052
124MP0003861_abnormal_nervous_system0.69415214
125MP0002751_abnormal_autonomic_nervous0.69407345
126MP0005647_abnormal_sex_gland0.66486301
127MP0002733_abnormal_thermal_nociception0.66332627
128MP0002638_abnormal_pupillary_reflex0.65439699
129MP0003755_abnormal_palate_morphology0.64591335
130MP0003787_abnormal_imprinting0.62596279
131MP0000762_abnormal_tongue_morphology0.61935768
132MP0001340_abnormal_eyelid_morphology0.61582861
133MP0000566_synostosis0.60236394
134MP0002132_abnormal_respiratory_system0.59159935

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.86479909
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.53416686
3Absent/shortened dynein arms (HP:0200106)9.53416686
4Abnormal respiratory epithelium morphology (HP:0012253)8.34665397
5Abnormal respiratory motile cilium morphology (HP:0005938)8.34665397
6Abnormal respiratory motile cilium physiology (HP:0012261)7.61127230
7Abnormal ciliary motility (HP:0012262)6.98226372
8Rhinitis (HP:0012384)6.09506481
9Infertility (HP:0000789)4.74274846
10Chronic bronchitis (HP:0004469)4.39075835
11Nephronophthisis (HP:0000090)3.88778119
12Male infertility (HP:0003251)3.55181432
13Bronchiectasis (HP:0002110)3.53119106
14Medial flaring of the eyebrow (HP:0010747)3.51749037
15Hyperventilation (HP:0002883)3.19094625
16Nasal polyposis (HP:0100582)3.12153244
17Gait imbalance (HP:0002141)3.01662642
18Median cleft lip (HP:0000161)3.00930693
19Abnormality of the renal medulla (HP:0100957)2.98607620
20Acute necrotizing encephalopathy (HP:0006965)2.94470165
21Congenital primary aphakia (HP:0007707)2.87840471
22Progressive cerebellar ataxia (HP:0002073)2.82501495
23Molar tooth sign on MRI (HP:0002419)2.82181446
24Abnormality of midbrain morphology (HP:0002418)2.82181446
25Genetic anticipation (HP:0003743)2.76769106
26Mitochondrial inheritance (HP:0001427)2.76198121
27Focal motor seizures (HP:0011153)2.76169418
28Abnormality of the renal cortex (HP:0011035)2.75406476
29Concave nail (HP:0001598)2.67729325
30Gaze-evoked nystagmus (HP:0000640)2.66781051
31Increased IgM level (HP:0003496)2.64003518
32Congenital stationary night blindness (HP:0007642)2.63425489
33Sclerocornea (HP:0000647)2.63010270
34Acute encephalopathy (HP:0006846)2.62983330
35Abnormal mitochondria in muscle tissue (HP:0008316)2.60721715
36Postaxial foot polydactyly (HP:0001830)2.60192015
37Nephrogenic diabetes insipidus (HP:0009806)2.59847470
38Increased CSF lactate (HP:0002490)2.57120662
39Progressive macrocephaly (HP:0004481)2.54765446
40Attenuation of retinal blood vessels (HP:0007843)2.54475580
41Pendular nystagmus (HP:0012043)2.53165665
42Type II lissencephaly (HP:0007260)2.52198920
43Recurrent sinusitis (HP:0011108)2.45627185
44Hepatocellular necrosis (HP:0001404)2.44220453
45Tubulointerstitial nephritis (HP:0001970)2.38848878
46Bronchitis (HP:0012387)2.37011804
47Genital tract atresia (HP:0001827)2.36812042
48Hepatic necrosis (HP:0002605)2.36403037
49Intestinal atresia (HP:0011100)2.36213065
50Renal cortical cysts (HP:0000803)2.35101263
51Lissencephaly (HP:0001339)2.32016280
52True hermaphroditism (HP:0010459)2.31464710
53Recurrent otitis media (HP:0000403)2.29070734
54Vaginal atresia (HP:0000148)2.28770589
55Anencephaly (HP:0002323)2.27156215
56Abolished electroretinogram (ERG) (HP:0000550)2.26606332
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.26091940
58Pancreatic fibrosis (HP:0100732)2.24299087
593-Methylglutaconic aciduria (HP:0003535)2.24065642
60Abnormality of the nasal mucosa (HP:0000433)2.23585248
61Poor coordination (HP:0002370)2.14180427
62Hemiparesis (HP:0001269)2.13422532
63Increased hepatocellular lipid droplets (HP:0006565)2.11089473
64Postaxial hand polydactyly (HP:0001162)2.11029379
65Bony spicule pigmentary retinopathy (HP:0007737)2.10097795
66Lipid accumulation in hepatocytes (HP:0006561)2.09684590
67Occipital encephalocele (HP:0002085)2.09532799
68Aplasia/Hypoplasia of the lens (HP:0008063)2.07128655
69Broad-based gait (HP:0002136)2.05907804
70Colon cancer (HP:0003003)2.05328234
71Choroideremia (HP:0001139)2.03975566
72Supernumerary spleens (HP:0009799)2.03653261
73Bile duct proliferation (HP:0001408)2.02970479
74Abnormal biliary tract physiology (HP:0012439)2.02970479
75Keratoconus (HP:0000563)2.02678561
76Increased corneal curvature (HP:0100692)2.02678561
77Tubular atrophy (HP:0000092)2.02590936
78Abnormality of macular pigmentation (HP:0008002)2.01235590
79Focal seizures (HP:0007359)1.99860220
80Aplasia/Hypoplasia of the uvula (HP:0010293)1.97430244
81Cerebellar dysplasia (HP:0007033)1.96798575
82Inability to walk (HP:0002540)1.96354145
83Retinal dysplasia (HP:0007973)1.94912693
84Rib fusion (HP:0000902)1.94245603
85Optic disc pallor (HP:0000543)1.93524549
86Pachygyria (HP:0001302)1.92638131
87Abnormal spermatogenesis (HP:0008669)1.91340104
88Hypothermia (HP:0002045)1.90689280
89Oculomotor apraxia (HP:0000657)1.90383324
90Rectal fistula (HP:0100590)1.89691198
91Rectovaginal fistula (HP:0000143)1.89691198
92Abnormal rod and cone electroretinograms (HP:0008323)1.89285469
93Type I transferrin isoform profile (HP:0003642)1.88292700
94Facial hemangioma (HP:0000329)1.88075395
95Severe visual impairment (HP:0001141)1.85751798
96Stage 5 chronic kidney disease (HP:0003774)1.85323539
97Male pseudohermaphroditism (HP:0000037)1.85259698
98Renal Fanconi syndrome (HP:0001994)1.84104533
99Short tibia (HP:0005736)1.84001016
100Dialeptic seizures (HP:0011146)1.83815196
101Bifid tongue (HP:0010297)1.83384580
102Methylmalonic aciduria (HP:0012120)1.82382511
103Abnormality of molar (HP:0011077)1.82102252
104Abnormality of molar morphology (HP:0011070)1.82102252
105Abnormal drinking behavior (HP:0030082)1.81912001
106Polydipsia (HP:0001959)1.81912001
107Abnormality of male internal genitalia (HP:0000022)1.81419388
108Volvulus (HP:0002580)1.81388652
109Bulbar palsy (HP:0001283)1.81169510
110Drooling (HP:0002307)1.80551954
111Furrowed tongue (HP:0000221)1.79394068
112Tongue fasciculations (HP:0001308)1.79320374
113Atonic seizures (HP:0010819)1.78003590
114Oligodactyly (hands) (HP:0001180)1.77768993
115Abnormality of permanent molar morphology (HP:0011071)1.76095754
116Abnormality of the dental root (HP:0006486)1.76095754
117Taurodontia (HP:0000679)1.76095754
118Absent speech (HP:0001344)1.76022173
119Fibular hypoplasia (HP:0003038)1.75490442
120Clumsiness (HP:0002312)1.74490888
121Nephroblastoma (Wilms tumor) (HP:0002667)1.73263222
122Hypotelorism (HP:0000601)1.72238758
123Optic nerve hypoplasia (HP:0000609)1.71778241
124Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71471407
125Short humerus (HP:0005792)1.70682321
126Tubulointerstitial abnormality (HP:0001969)1.70035029
127Narrow nasal bridge (HP:0000446)1.69307112
128Alacrima (HP:0000522)1.68602554
129Febrile seizures (HP:0002373)1.66757161
130Congenital hepatic fibrosis (HP:0002612)1.65155990
131Aplasia/Hypoplasia of the tongue (HP:0010295)1.61983858
132Embryonal renal neoplasm (HP:0011794)1.61938248
133Decreased central vision (HP:0007663)1.61126264
134Abnormality of the dental pulp (HP:0006479)1.61040168
135Amelogenesis imperfecta (HP:0000705)1.59755774
136Type 2 muscle fiber atrophy (HP:0003554)1.58862336
137Impulsivity (HP:0100710)1.57730063
138Gonadotropin excess (HP:0000837)1.57472327
139Intestinal fistula (HP:0100819)1.57427830
140Aplasia/hypoplasia of the humerus (HP:0006507)1.57168080
141Broad alveolar ridges (HP:0000187)1.56572008
142Aganglionic megacolon (HP:0002251)1.55713484
143Gastrointestinal atresia (HP:0002589)1.54728872
144Pancreatic cysts (HP:0001737)1.52948586
145Alopecia of scalp (HP:0002293)1.52331735
146Anteriorly placed anus (HP:0001545)1.52026674
147Dyschromatopsia (HP:0007641)1.51910458
148Ectopic anus (HP:0004397)1.51564327
149Preaxial hand polydactyly (HP:0001177)1.48238151
150Vaginal fistula (HP:0004320)1.47727296
151Azoospermia (HP:0000027)1.47075524
152Astigmatism (HP:0000483)1.46232906
153Cystic liver disease (HP:0006706)1.44340362
154Coronal craniosynostosis (HP:0004440)1.43532851
155Muscle fibrillation (HP:0010546)1.43478407
156Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.43262596
157Microglossia (HP:0000171)1.42542119
158Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.42455098
159Chronic hepatic failure (HP:0100626)1.42319858
160Specific learning disability (HP:0001328)1.42251624
161Septo-optic dysplasia (HP:0100842)1.42221248
162Epileptic encephalopathy (HP:0200134)1.41546770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.46004743
2MAPK154.84134362
3FRK4.68049807
4PDK34.50425804
5PDK44.50425804
6WNK33.19733081
7PDK22.90559940
8DDR22.86694848
9MAP4K22.83073994
10PINK12.79771854
11TESK12.73944181
12MAP3K62.64168956
13YES12.39707051
14NUAK12.31756173
15TYRO32.16565076
16PNCK2.09614238
17PRKD32.07702717
18FGR1.94708363
19DYRK1B1.75406563
20OXSR11.75126878
21UHMK11.74688502
22CDK191.73972346
23TAOK31.59095233
24PLK21.54642143
25STK391.48892638
26PAK31.42807506
27NTRK21.41403689
28MATK1.40939138
29CSNK1G21.38000285
30AKT31.36132887
31ACVR1B1.32883991
32ERBB31.32612904
33PRPF4B1.32130845
34MKNK21.30351307
35CSNK1G31.30306221
36PIM21.22962257
37CSNK1G11.22474341
38TRIM281.19242117
39VRK11.16835815
40MARK11.16604486
41DAPK11.16410995
42WNK41.15637455
43PRKD21.15315058
44BCKDK1.15096849
45CSK1.12328248
46CSNK1A1L1.09786360
47PTK2B1.09782395
48VRK21.07810392
49PLK41.07087860
50TNK21.05890812
51CCNB11.03416665
52CASK0.97350105
53CHEK20.96976267
54TLK10.95400126
55PHKG20.95243508
56PHKG10.95243508
57MKNK10.95212593
58TAF10.93974343
59DYRK30.93790481
60MAP3K110.93475327
61BMPR1B0.93455404
62PIK3CG0.93189771
63DYRK20.91093100
64MAP2K70.84399887
65STK38L0.83984887
66ADRBK10.82019233
67EIF2AK30.76780687
68BMX0.76659690
69CDK70.75908204
70EPHB20.75433813
71TRPM70.74780344
72STK160.73557061
73CAMK2A0.73438812
74STK380.72066061
75BMPR20.70243235
76MAPKAPK50.68832511
77TNIK0.68382139
78OBSCN0.67839158
79CDC42BPA0.65056661
80MAPK130.64861716
81DAPK20.63794700
82RPS6KC10.62847311
83RPS6KL10.62847311
84BCR0.62822738
85RPS6KB10.59669989
86NTRK30.59209874
87LATS10.58957648
88GSK3A0.58633305
89PLK30.58245146
90CAMK2B0.57413672
91MAP3K40.56967090
92WEE10.56763066
93PIM10.56493903
94NEK60.54624362
95ATR0.54555101
96ADRBK20.51756467
97RPS6KA60.51488776
98INSRR0.51290876
99PRKAA10.50689629
100PRKACA0.50371193
101CSNK1A10.49791666
102TIE10.49114427
103RPS6KA40.48818155
104SIK30.48675533
105RPS6KA50.48304083
106BRSK20.47864615
107TGFBR10.47711902
108PIK3CA0.45655637
109EPHA40.45556691
110ATM0.44613080
111WNK10.43175337
112CAMKK20.43116141
113GRK70.43043898
114ZAK0.43035906
115MAP2K40.42745746
116PRKCG0.42634991
117MAPKAPK30.42567473
118CAMK2D0.42304379
119FER0.41592186
120PKN10.41069289
121IRAK20.41050454
122IRAK10.40901402
123CDK80.40819749
124PRKG10.40358520
125STK30.40188960
126MINK10.39290334
127PLK10.37937657
128SGK20.37303960
129PRKCQ0.36728490
130GRK10.36627470
131PDGFRA0.36467189
132TAOK20.35724838
133CSNK2A10.34832923
134CAMK10.34104196
135MST40.33910282
136CDK30.33714932
137CAMK2G0.33369833
138SGK10.33114761
139CDC70.31990585
140PRKACB0.31129360
141GRK50.30482400
142NME10.29585100
143MUSK0.29281679
144LATS20.27992585
145CHEK10.26131215
146PRKCZ0.25887123
147TXK0.25511902
148GSK3B0.24810809
149PRKCE0.24571031
150CDK50.24251944
151MAP2K60.23928859
152RPS6KA10.23684020
153AURKA0.23521142
154DYRK1A0.23420404
155LYN0.23076810
156CDK180.22162417
157MAPK140.21027432

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.42377082
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.61058193
3Butanoate metabolism_Homo sapiens_hsa006502.68708559
4Fanconi anemia pathway_Homo sapiens_hsa034602.54793449
5Protein export_Homo sapiens_hsa030602.41987165
6Nicotine addiction_Homo sapiens_hsa050332.33385847
7Huntingtons disease_Homo sapiens_hsa050162.23093530
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19548172
9Base excision repair_Homo sapiens_hsa034102.18198037
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16375308
11Basal transcription factors_Homo sapiens_hsa030222.15237567
12Propanoate metabolism_Homo sapiens_hsa006402.00595057
13Nitrogen metabolism_Homo sapiens_hsa009101.94983678
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.85624368
15Hedgehog signaling pathway_Homo sapiens_hsa043401.79378012
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75244911
17Mismatch repair_Homo sapiens_hsa034301.73450458
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71793068
19mRNA surveillance pathway_Homo sapiens_hsa030151.71506057
20Oxidative phosphorylation_Homo sapiens_hsa001901.70733890
21RNA polymerase_Homo sapiens_hsa030201.68903904
22Amphetamine addiction_Homo sapiens_hsa050311.66753898
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65066256
24Circadian rhythm_Homo sapiens_hsa047101.62670668
25Non-homologous end-joining_Homo sapiens_hsa034501.61211345
26Phototransduction_Homo sapiens_hsa047441.56132101
27Cardiac muscle contraction_Homo sapiens_hsa042601.53633904
28Linoleic acid metabolism_Homo sapiens_hsa005911.47442534
29Taste transduction_Homo sapiens_hsa047421.44727771
30Peroxisome_Homo sapiens_hsa041461.43668888
31Dorso-ventral axis formation_Homo sapiens_hsa043201.41834150
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41443436
33Selenocompound metabolism_Homo sapiens_hsa004501.39312691
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37332731
35Mineral absorption_Homo sapiens_hsa049781.36764813
36Homologous recombination_Homo sapiens_hsa034401.36091760
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35926685
38Tryptophan metabolism_Homo sapiens_hsa003801.34026159
39Regulation of autophagy_Homo sapiens_hsa041401.33155555
40Wnt signaling pathway_Homo sapiens_hsa043101.29671680
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29652673
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.28838254
43Oocyte meiosis_Homo sapiens_hsa041141.28192668
44Vitamin B6 metabolism_Homo sapiens_hsa007501.25934786
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21239848
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20366553
47Parkinsons disease_Homo sapiens_hsa050121.20149784
48Olfactory transduction_Homo sapiens_hsa047401.19809487
49Morphine addiction_Homo sapiens_hsa050321.18134492
50Ether lipid metabolism_Homo sapiens_hsa005651.15755483
51Collecting duct acid secretion_Homo sapiens_hsa049661.14942160
52Nucleotide excision repair_Homo sapiens_hsa034201.12770016
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09505067
54Fatty acid elongation_Homo sapiens_hsa000621.09460611
55Alzheimers disease_Homo sapiens_hsa050101.06943966
56Caffeine metabolism_Homo sapiens_hsa002321.04660656
57Chemical carcinogenesis_Homo sapiens_hsa052041.02431456
58Basal cell carcinoma_Homo sapiens_hsa052171.02303616
59Steroid hormone biosynthesis_Homo sapiens_hsa001401.01710192
60ABC transporters_Homo sapiens_hsa020100.95064826
61RNA transport_Homo sapiens_hsa030130.94034995
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93988804
63Arachidonic acid metabolism_Homo sapiens_hsa005900.93716225
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.92941744
65Glutamatergic synapse_Homo sapiens_hsa047240.91872318
66beta-Alanine metabolism_Homo sapiens_hsa004100.90892779
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89582902
68Glucagon signaling pathway_Homo sapiens_hsa049220.89568174
69Synaptic vesicle cycle_Homo sapiens_hsa047210.89329153
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88759677
71Circadian entrainment_Homo sapiens_hsa047130.88435533
72Renin secretion_Homo sapiens_hsa049240.87896175
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86941544
74GABAergic synapse_Homo sapiens_hsa047270.85945007
75Retinol metabolism_Homo sapiens_hsa008300.84831908
76Serotonergic synapse_Homo sapiens_hsa047260.84071415
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83963385
78Graft-versus-host disease_Homo sapiens_hsa053320.83720160
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83400981
80DNA replication_Homo sapiens_hsa030300.81787811
81Hippo signaling pathway_Homo sapiens_hsa043900.80067606
82Steroid biosynthesis_Homo sapiens_hsa001000.79931738
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79506386
84One carbon pool by folate_Homo sapiens_hsa006700.76886229
85Calcium signaling pathway_Homo sapiens_hsa040200.74136581
86Metabolic pathways_Homo sapiens_hsa011000.74049155
87Long-term potentiation_Homo sapiens_hsa047200.73328281
88Spliceosome_Homo sapiens_hsa030400.72652172
89Insulin secretion_Homo sapiens_hsa049110.72122318
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71715009
91Rheumatoid arthritis_Homo sapiens_hsa053230.70956493
92Purine metabolism_Homo sapiens_hsa002300.70892451
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70865916
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69801935
95Fructose and mannose metabolism_Homo sapiens_hsa000510.68078254
96Cocaine addiction_Homo sapiens_hsa050300.66816505
97Axon guidance_Homo sapiens_hsa043600.66658530
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.65911822
99Dopaminergic synapse_Homo sapiens_hsa047280.65153006
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64682124
101Fatty acid metabolism_Homo sapiens_hsa012120.64480579
102Ribosome_Homo sapiens_hsa030100.63525445
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59647510
104Fatty acid degradation_Homo sapiens_hsa000710.57998135
105Notch signaling pathway_Homo sapiens_hsa043300.57587149
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56645254
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56627087
108RNA degradation_Homo sapiens_hsa030180.56584882
109Pyrimidine metabolism_Homo sapiens_hsa002400.54532595
110Sphingolipid metabolism_Homo sapiens_hsa006000.54463356
111Autoimmune thyroid disease_Homo sapiens_hsa053200.53624170
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52406630
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52333193
114Estrogen signaling pathway_Homo sapiens_hsa049150.51982194
115MAPK signaling pathway_Homo sapiens_hsa040100.50299296
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.48824868
117Long-term depression_Homo sapiens_hsa047300.48625690
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48320125
119ErbB signaling pathway_Homo sapiens_hsa040120.47815525
120Allograft rejection_Homo sapiens_hsa053300.47338815
121Glutathione metabolism_Homo sapiens_hsa004800.47162530
122TGF-beta signaling pathway_Homo sapiens_hsa043500.47149798
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46548033
124Gap junction_Homo sapiens_hsa045400.46517457
125Legionellosis_Homo sapiens_hsa051340.46490489
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45945374
127Choline metabolism in cancer_Homo sapiens_hsa052310.45572861
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44601041
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43737390
130Salivary secretion_Homo sapiens_hsa049700.43579120
131Phagosome_Homo sapiens_hsa041450.42758324
132Arginine and proline metabolism_Homo sapiens_hsa003300.41808694
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40354654
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40024782
135Tyrosine metabolism_Homo sapiens_hsa003500.39989204
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39726239
137Pyruvate metabolism_Homo sapiens_hsa006200.38105952
138N-Glycan biosynthesis_Homo sapiens_hsa005100.36868494
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36645842
140Melanogenesis_Homo sapiens_hsa049160.35487179
141Type I diabetes mellitus_Homo sapiens_hsa049400.35400150
142Proteasome_Homo sapiens_hsa030500.34890038
143Cell cycle_Homo sapiens_hsa041100.34394963
144cAMP signaling pathway_Homo sapiens_hsa040240.34371825
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33721784
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33322139
147Ovarian steroidogenesis_Homo sapiens_hsa049130.32389628
148Cholinergic synapse_Homo sapiens_hsa047250.30329272
149Glycerolipid metabolism_Homo sapiens_hsa005610.29448963

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »