CDKL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.43902300
2cilium movement (GO:0003341)8.12226165
3axonemal dynein complex assembly (GO:0070286)7.82553931
4epithelial cilium movement (GO:0003351)6.88686113
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.47422576
6negative regulation of mast cell activation (GO:0033004)5.48445806
7motile cilium assembly (GO:0044458)5.35576143
8axoneme assembly (GO:0035082)5.34359731
9regulation of cilium movement (GO:0003352)5.25306683
10CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)5.22662349
11T-helper cell differentiation (GO:0042093)5.22662349
12male meiosis I (GO:0007141)5.04953991
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.97893462
14detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.95823769
15DNA methylation involved in gamete generation (GO:0043046)4.86898722
16protein localization to cilium (GO:0061512)4.85541281
17protein K6-linked ubiquitination (GO:0085020)4.84781506
18monoubiquitinated protein deubiquitination (GO:0035520)4.83854215
19synaptic vesicle exocytosis (GO:0016079)4.63341168
20neuron cell-cell adhesion (GO:0007158)4.63180520
21sensory perception of smell (GO:0007608)4.62767104
22ventricular system development (GO:0021591)4.62690349
23glutamate secretion (GO:0014047)4.61832639
24regulation of short-term neuronal synaptic plasticity (GO:0048172)4.55518054
25regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.55112367
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.50203185
27protein localization to synapse (GO:0035418)4.45917412
28alpha-beta T cell differentiation involved in immune response (GO:0002293)4.45510116
29alpha-beta T cell activation involved in immune response (GO:0002287)4.45510116
30T cell differentiation involved in immune response (GO:0002292)4.45510116
31negative regulation of inclusion body assembly (GO:0090084)4.42857764
32synapsis (GO:0007129)4.41596150
33positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.39327833
34vocalization behavior (GO:0071625)4.37596511
35sperm motility (GO:0030317)4.36319997
36acrosome reaction (GO:0007340)4.28335131
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24771064
38regulation of glutamate receptor signaling pathway (GO:1900449)4.16110073
39calcium ion-dependent exocytosis (GO:0017156)4.15461931
40regulation of synaptic vesicle exocytosis (GO:2000300)4.11390503
41piRNA metabolic process (GO:0034587)4.09115484
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.08917456
43regulation of centriole replication (GO:0046599)4.05009537
44centriole replication (GO:0007099)4.04519748
45fusion of sperm to egg plasma membrane (GO:0007342)3.98305302
46CD4-positive, alpha-beta T cell activation (GO:0035710)3.97795879
47CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.91973628
48synaptic vesicle maturation (GO:0016188)3.87627993
49meiosis I (GO:0007127)3.86133701
50ionotropic glutamate receptor signaling pathway (GO:0035235)3.85987093
51intraciliary transport (GO:0042073)3.83436887
52locomotory exploration behavior (GO:0035641)3.81958490
53glutamate receptor signaling pathway (GO:0007215)3.74668352
54neuronal action potential propagation (GO:0019227)3.72071301
55detection of calcium ion (GO:0005513)3.71876212
56regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.71027224
57negative regulation of neurological system process (GO:0031645)3.70498290
58regulation of synaptic vesicle transport (GO:1902803)3.70053070
59response to pheromone (GO:0019236)3.66530667
60Golgi to endosome transport (GO:0006895)3.66212111
61long-term synaptic potentiation (GO:0060291)3.64547919
62acrosome assembly (GO:0001675)3.64359084
63nucleoside diphosphate phosphorylation (GO:0006165)3.63122468
64neurotransmitter-gated ion channel clustering (GO:0072578)3.61350307
65male meiosis (GO:0007140)3.60429783
66plasma membrane fusion (GO:0045026)3.57425522
67synaptic transmission, glutamatergic (GO:0035249)3.56844047
68chromosome organization involved in meiosis (GO:0070192)3.55482098
69presynaptic membrane assembly (GO:0097105)3.54401354
70neuron-neuron synaptic transmission (GO:0007270)3.49647612
71protein localization to Golgi apparatus (GO:0034067)3.47097744
72regulation of neuronal synaptic plasticity (GO:0048168)3.45259862
73protein polyglutamylation (GO:0018095)3.42971194
74spermatid development (GO:0007286)3.41789441
75protein targeting to Golgi (GO:0000042)3.40977654
76multicellular organism reproduction (GO:0032504)3.40200645
77regulation of long-term neuronal synaptic plasticity (GO:0048169)3.38366084
78positive regulation of natural killer cell differentiation (GO:0032825)3.38341064
79membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35975516
80regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34980627
81regulation of microtubule-based movement (GO:0060632)3.34911977
82establishment of protein localization to Golgi (GO:0072600)3.34811382
83female mating behavior (GO:0060180)3.33163042
84auditory receptor cell stereocilium organization (GO:0060088)3.31794001
85meiotic nuclear division (GO:0007126)3.31196579
86regulation of glutamate secretion (GO:0014048)3.30305553
87microtubule-based movement (GO:0007018)3.30219488
88exploration behavior (GO:0035640)3.29285863
89reproduction (GO:0000003)3.28854130
90positive regulation of neurotransmitter secretion (GO:0001956)3.25361384
91microtubule severing (GO:0051013)3.25220309
92microtubule polymerization or depolymerization (GO:0031109)3.24526197
93regulation of synaptic plasticity (GO:0048167)3.23387545
94neuron recognition (GO:0008038)3.21989620
95axonal fasciculation (GO:0007413)3.21357053
96neurotransmitter secretion (GO:0007269)3.20515494
97regulation of postsynaptic membrane potential (GO:0060078)3.19993907
98regulation of inclusion body assembly (GO:0090083)3.19456942
99sperm-egg recognition (GO:0035036)3.19144513
100regulation of mitotic spindle checkpoint (GO:1903504)3.16888837
101regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16888837
102G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16810220
103synaptonemal complex organization (GO:0070193)3.15748750
104presynaptic membrane organization (GO:0097090)3.15447081
105regulation of neurotransmitter secretion (GO:0046928)3.14128052
106proline transport (GO:0015824)3.12817431
107cilium organization (GO:0044782)3.12687360
108gamma-aminobutyric acid signaling pathway (GO:0007214)3.11753665
109snRNA transcription (GO:0009301)3.11622153
110synaptonemal complex assembly (GO:0007130)3.10823226
111histone H3-K9 demethylation (GO:0033169)3.10641218
112genitalia morphogenesis (GO:0035112)3.10337903
113positive regulation of synapse maturation (GO:0090129)3.09580444
114startle response (GO:0001964)3.08937222
115cilium assembly (GO:0042384)3.06908313
116behavioral response to cocaine (GO:0048148)3.06343294
117regulation of synaptic transmission, glutamatergic (GO:0051966)3.04363687
118regulation of female receptivity (GO:0045924)3.03370828
119left/right axis specification (GO:0070986)3.03269103
120membrane depolarization during action potential (GO:0086010)3.03203014
121positive regulation of membrane potential (GO:0045838)3.02911569
122regulation of meiosis I (GO:0060631)3.02619814
123regulation of centrosome duplication (GO:0010824)3.02520980
124response to histamine (GO:0034776)3.01954202
125single fertilization (GO:0007338)3.01124882
126microtubule bundle formation (GO:0001578)3.00651112
127sensory perception of chemical stimulus (GO:0007606)2.99512087
128positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.99140663
129fertilization (GO:0009566)2.97268207
130postsynaptic membrane organization (GO:0001941)2.96465511
131long-term memory (GO:0007616)2.95841587
132behavioral fear response (GO:0001662)2.95545326
133behavioral defense response (GO:0002209)2.95545326
134molting cycle (GO:0042303)2.93861390
135hair cycle (GO:0042633)2.93861390
136negative regulation of amino acid transport (GO:0051956)2.93053574
137negative regulation of signal transduction by p53 class mediator (GO:1901797)2.92185339
138positive regulation of neurotransmitter transport (GO:0051590)2.92040149
139rRNA methylation (GO:0031167)2.91410816
140detection of mechanical stimulus involved in sensory perception (GO:0050974)2.91110391
141regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.91097273
142signal peptide processing (GO:0006465)2.89546750
143cell-cell recognition (GO:0009988)2.88910124
144activation of protein kinase A activity (GO:0034199)2.88016897
145binding of sperm to zona pellucida (GO:0007339)2.87138053
146positive regulation of NF-kappaB import into nucleus (GO:0042346)2.87065309
147membrane depolarization (GO:0051899)2.86633647
148centriole assembly (GO:0098534)2.85400826
149retrograde transport, vesicle recycling within Golgi (GO:0000301)2.85009072
150cilium morphogenesis (GO:0060271)2.84155577
151regulation of histone H3-K9 methylation (GO:0051570)2.83721374
152regulation of histone H3-K27 methylation (GO:0061085)2.80277442
153spermatogenesis (GO:0007283)2.78419516
154negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.77364559
155platelet dense granule organization (GO:0060155)2.77309182
156positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.77258482
157male gamete generation (GO:0048232)2.77171427
158meiotic cell cycle process (GO:1903046)2.75076097
159negative regulation of meiotic cell cycle (GO:0051447)2.73005783
160tolerance induction (GO:0002507)2.70619666
161keratinocyte development (GO:0003334)2.69376489
162norepinephrine metabolic process (GO:0042415)2.64582552
163regulation of mesoderm development (GO:2000380)2.64032879
164interferon-gamma secretion (GO:0072643)2.63683469
165gamete generation (GO:0007276)2.63369496
166negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.62880620
167transepithelial transport (GO:0070633)2.61349785
168iron ion import (GO:0097286)2.60751669
169embryonic epithelial tube formation (GO:0001838)2.60133618
170regulation of signal transduction by p53 class mediator (GO:1901796)2.59294211
171indolalkylamine catabolic process (GO:0046218)2.59108870
172tryptophan catabolic process (GO:0006569)2.59108870
173indole-containing compound catabolic process (GO:0042436)2.59108870
174regulation of interleukin-13 production (GO:0032656)2.58691995
175sperm capacitation (GO:0048240)2.58360176
176microtubule depolymerization (GO:0007019)2.57142550
177sister chromatid cohesion (GO:0007062)2.56610957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.76127354
2GBX2_23144817_ChIP-Seq_PC3_Human3.38129440
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.26532447
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.08961946
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.68065442
6TAF15_26573619_Chip-Seq_HEK293_Human2.64459550
7REST_21632747_ChIP-Seq_MESCs_Mouse2.57121168
8IGF1R_20145208_ChIP-Seq_DFB_Human2.55907024
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.40244601
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35837195
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.20915297
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18829118
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17216563
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15347369
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13717326
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03416040
17* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01454228
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00636750
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99957689
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.98161593
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97083933
22DROSHA_22980978_ChIP-Seq_HELA_Human1.94649686
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93670772
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90810196
25SMAD4_21799915_ChIP-Seq_A2780_Human1.90354645
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.89838065
27* RARB_27405468_Chip-Seq_BRAIN_Mouse1.89522784
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85866303
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82630364
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82035090
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80627375
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80627375
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78135545
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75503386
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.74683175
36VDR_22108803_ChIP-Seq_LS180_Human1.72765709
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71944344
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68652697
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68193338
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67710773
41P300_19829295_ChIP-Seq_ESCs_Human1.67631226
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.66854473
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61765448
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.61457324
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.60773957
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60205599
47CDX2_22108803_ChIP-Seq_LS180_Human1.60164329
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59902733
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.59695359
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58941170
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.54923551
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54163493
53RNF2_27304074_Chip-Seq_NSC_Mouse1.53384470
54TCF4_22108803_ChIP-Seq_LS180_Human1.51153502
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.49200556
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49120489
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48665003
58RXR_22108803_ChIP-Seq_LS180_Human1.48622169
59FUS_26573619_Chip-Seq_HEK293_Human1.48494162
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.45232263
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44813168
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43669015
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42963406
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.41623813
65* ETV1_20927104_ChIP-Seq_GIST48_Human1.38792120
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.34969070
67WDR5_24793694_ChIP-Seq_LNCAP_Human1.34529232
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34470042
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33485735
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30695528
71* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30690033
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29083073
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.29080873
74AR_21572438_ChIP-Seq_LNCaP_Human1.29053701
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28633722
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28633722
77PHF8_20622853_ChIP-Seq_HELA_Human1.28595031
78TP53_16413492_ChIP-PET_HCT116_Human1.27527977
79TCF4_23295773_ChIP-Seq_U87_Human1.27382907
80STAT3_23295773_ChIP-Seq_U87_Human1.27317115
81* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26753440
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.25741148
83ER_23166858_ChIP-Seq_MCF-7_Human1.24278360
84TBL1_22424771_ChIP-Seq_293T_Human1.23959693
85* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23619566
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23480798
87AR_25329375_ChIP-Seq_VCAP_Human1.23255369
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23249332
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23053066
90NFYB_21822215_ChIP-Seq_K562_Human1.22579874
91* ARNT_22903824_ChIP-Seq_MCF-7_Human1.21694463
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21623291
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.21436969
94BRD4_25478319_ChIP-Seq_HGPS_Human1.20767601
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20659728
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.20355536
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20035869
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19923119
99MYC_18940864_ChIP-ChIP_HL60_Human1.19606593
100BCAT_22108803_ChIP-Seq_LS180_Human1.19450705
101ZNF274_21170338_ChIP-Seq_K562_Hela1.19312290
102CJUN_26792858_Chip-Seq_BT549_Human1.19086931
103* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.18473141
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18353006
105* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18107986
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.18067861
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17675127
108* EWS_26573619_Chip-Seq_HEK293_Human1.15819040
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15778097
110P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15496804
111* AHR_22903824_ChIP-Seq_MCF-7_Human1.15334698
112RBPJ_21746931_ChIP-Seq_IB4_Human1.14491033
113CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.13547827
114FLI1_27457419_Chip-Seq_LIVER_Mouse1.12984639
115RUNX2_22187159_ChIP-Seq_PCA_Human1.12206377
116TP63_23658742_ChIP-Seq_EP156T_Human1.11967637
117SALL4_22934838_ChIP-ChIP_CD34+_Human1.11913880
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11355198
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11252583
120GATA4_25053715_ChIP-Seq_YYC3_Human1.10470905
121HNFA_21074721_ChIP-Seq_CACO-2_Human1.10450280
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10205477
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.10161291
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09490060
125TP53_22573176_ChIP-Seq_HFKS_Human1.09111192
126JUN_21703547_ChIP-Seq_K562_Human1.09014060
127ESR1_21235772_ChIP-Seq_MCF-7_Human1.08562818
128SOX2_21211035_ChIP-Seq_LN229_Gbm1.08135487
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07326977
130CBP_20019798_ChIP-Seq_JUKART_Human1.07304075
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07304075
132* KDM2B_26808549_Chip-Seq_REH_Human1.06589589
133RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06588645
134GATA3_26560356_Chip-Seq_TH2_Human1.05446601
135TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04971245
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04784022
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04479543
138* NANOG_19829295_ChIP-Seq_ESCs_Human1.04034812
139* SOX2_19829295_ChIP-Seq_ESCs_Human1.04034812
140RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03958128
141FLI1_21867929_ChIP-Seq_TH2_Mouse1.03659968
142* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03171084
143SOX9_26525672_Chip-Seq_HEART_Mouse1.02957876
144P53_22387025_ChIP-Seq_ESCs_Mouse1.02594191
145OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02348079
146E2F1_18555785_Chip-Seq_ESCs_Mouse1.02251165
147SMAD4_21741376_ChIP-Seq_EPCs_Human1.02198412
148NFYA_21822215_ChIP-Seq_K562_Human1.02107938
149PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01983140
150KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00263621
151TAL1_26923725_Chip-Seq_HPCs_Mouse0.99781145
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.99536736
153ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99468003
154NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98486326
155CMYC_18555785_Chip-Seq_ESCs_Mouse0.97287539
156SOX2_18555785_Chip-Seq_ESCs_Mouse0.95699943

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.49136953
2MP0004381_abnormal_hair_follicle5.36713789
3MP0003880_abnormal_central_pattern5.29807652
4MP0000569_abnormal_digit_pigmentation5.16913166
5MP0000427_abnormal_hair_cycle4.41365147
6MP0001984_abnormal_olfaction4.32807740
7MP0005410_abnormal_fertilization4.08718438
8MP0005075_abnormal_melanosome_morpholog3.92666184
9MP0003635_abnormal_synaptic_transmissio3.74059333
10MP0004270_analgesia3.43404611
11MP0009745_abnormal_behavioral_response3.09992640
12MP0002063_abnormal_learning/memory/cond3.07678593
13MP0002064_seizures3.00468954
14MP0009046_muscle_twitch2.91230991
15MP0001661_extended_life_span2.87179398
16MP0001968_abnormal_touch/_nociception2.83007996
17MP0002572_abnormal_emotion/affect_behav2.67276695
18MP0005174_abnormal_tail_pigmentation2.58308410
19MP0002638_abnormal_pupillary_reflex2.48763560
20MP0002009_preneoplasia2.47222429
21MP0002272_abnormal_nervous_system2.42373735
22MP0002736_abnormal_nociception_after2.38728536
23MP0001486_abnormal_startle_reflex2.35373165
24MP0002734_abnormal_mechanical_nocicepti2.34423667
25MP0000372_irregular_coat_pigmentation2.33869623
26MP0001440_abnormal_grooming_behavior2.33303668
27MP0009697_abnormal_copulation2.29386652
28MP0002653_abnormal_ependyma_morphology2.28492425
29MP0005171_absent_coat_pigmentation2.18351329
30MP0005408_hypopigmentation2.16819312
31MP0005423_abnormal_somatic_nervous2.16183437
32MP0001501_abnormal_sleep_pattern2.12054424
33MP0002822_catalepsy2.08613299
34MP0002282_abnormal_trachea_morphology2.08187246
35MP0003329_amyloid_beta_deposits2.01247126
36MP0008877_abnormal_DNA_methylation2.00568397
37MP0004147_increased_porphyrin_level1.99718445
38MP0003879_abnormal_hair_cell1.95048931
39MP0005083_abnormal_biliary_tract1.91011047
40MP0005451_abnormal_body_composition1.90849850
41MP0000015_abnormal_ear_pigmentation1.89421802
42MP0003698_abnormal_male_reproductive1.88511100
43MP0005646_abnormal_pituitary_gland1.86676236
44MP0002067_abnormal_sensory_capabilities1.85354497
45MP0005645_abnormal_hypothalamus_physiol1.83502966
46MP0000778_abnormal_nervous_system1.82981749
47MP0003950_abnormal_plasma_membrane1.82170536
48MP0005499_abnormal_olfactory_system1.79201527
49MP0005394_taste/olfaction_phenotype1.79201527
50MP0003890_abnormal_embryonic-extraembry1.78156183
51MP0002735_abnormal_chemical_nociception1.77383501
52MP0000383_abnormal_hair_follicle1.76642435
53MP0006276_abnormal_autonomic_nervous1.76608828
54MP0002557_abnormal_social/conspecific_i1.73415042
55MP0006072_abnormal_retinal_apoptosis1.72993596
56MP0002095_abnormal_skin_pigmentation1.72872460
57MP0004043_abnormal_pH_regulation1.70008965
58MP0005623_abnormal_meninges_morphology1.68517587
59MP0003718_maternal_effect1.66131898
60MP0002184_abnormal_innervation1.65543986
61MP0000465_gastrointestinal_hemorrhage1.64602518
62MP0003724_increased_susceptibility_to1.62615709
63MP0000371_diluted_coat_color1.60542821
64MP0001970_abnormal_pain_threshold1.58204517
65MP0003195_calcinosis1.56818250
66MP0000647_abnormal_sebaceous_gland1.51901634
67MP0005670_abnormal_white_adipose1.48819878
68MP0004811_abnormal_neuron_physiology1.45213124
69MP0002733_abnormal_thermal_nociception1.44886397
70MP0001929_abnormal_gametogenesis1.44460908
71MP0003787_abnormal_imprinting1.43337853
72MP0008569_lethality_at_weaning1.43120660
73MP0004858_abnormal_nervous_system1.36460396
74MP0004924_abnormal_behavior1.36183060
75MP0005386_behavior/neurological_phenoty1.36183060
76MP0002882_abnormal_neuron_morphology1.35972084
77MP0010678_abnormal_skin_adnexa1.35047778
78MP0002160_abnormal_reproductive_system1.33495803
79MP0001485_abnormal_pinna_reflex1.33265908
80MP0008789_abnormal_olfactory_epithelium1.31520259
81MP0001529_abnormal_vocalization1.28534216
82MP0002234_abnormal_pharynx_morphology1.27806136
83MP0003656_abnormal_erythrocyte_physiolo1.25941748
84MP0010094_abnormal_chromosome_stability1.24735412
85MP0002066_abnormal_motor_capabilities/c1.22047297
86MP0000955_abnormal_spinal_cord1.21522502
87MP0010030_abnormal_orbit_morphology1.20213697
88MP0000639_abnormal_adrenal_gland1.19886379
89MP0003786_premature_aging1.19493468
90MP0002152_abnormal_brain_morphology1.17784940
91MP0002909_abnormal_adrenal_gland1.14646072
92MP0004142_abnormal_muscle_tone1.13602486
93MP0000013_abnormal_adipose_tissue1.13322691
94MP0003633_abnormal_nervous_system1.13245849
95MP0002876_abnormal_thyroid_physiology1.10763143
96MP0001963_abnormal_hearing_physiology1.10057025
97MP0001905_abnormal_dopamine_level1.09125881
98MP0009780_abnormal_chondrocyte_physiolo1.09095588
99MP0002132_abnormal_respiratory_system1.07673841
100MP0004133_heterotaxia1.07366819
101MP0004134_abnormal_chest_morphology1.07020003
102MP0002161_abnormal_fertility/fecundity1.06454503
103MP0008057_abnormal_DNA_replication1.06116013
104MP0003868_abnormal_feces_composition1.06000842
105MP0004742_abnormal_vestibular_system1.05295012
106MP0005551_abnormal_eye_electrophysiolog1.04085886
107MP0004264_abnormal_extraembryonic_tissu1.00698355
108MP0000534_abnormal_ureter_morphology0.99067347
109MP0002210_abnormal_sex_determination0.97836584
110MP0001502_abnormal_circadian_rhythm0.96980539
111MP0003936_abnormal_reproductive_system0.96857821
112MP0000604_amyloidosis0.96677067
113MP0003631_nervous_system_phenotype0.96473191
114MP0005253_abnormal_eye_physiology0.94709519
115MP0002837_dystrophic_cardiac_calcinosis0.93114066
116MP0004885_abnormal_endolymph0.90203806
117MP0002229_neurodegeneration0.89127998
118MP0002752_abnormal_somatic_nervous0.88583583
119MP0002102_abnormal_ear_morphology0.87236590
120MP0003943_abnormal_hepatobiliary_system0.86430625
121MP0000579_abnormal_nail_morphology0.85787525
122MP0000678_abnormal_parathyroid_gland0.85744798
123MP0000377_abnormal_hair_follicle0.85002015
124MP0000026_abnormal_inner_ear0.82725817
125MP0003878_abnormal_ear_physiology0.82545898
126MP0005377_hearing/vestibular/ear_phenot0.82545898
127MP0008874_decreased_physiological_sensi0.82409746
128MP0003634_abnormal_glial_cell0.82379653
129MP0010386_abnormal_urinary_bladder0.82175575
130MP0005360_urolithiasis0.80704876
131MP0003122_maternal_imprinting0.79721693
132MP0001324_abnormal_eye_pigmentation0.75841866
133MP0002069_abnormal_eating/drinking_beha0.73882176
134MP0008872_abnormal_physiological_respon0.73041436
135MP0008004_abnormal_stomach_pH0.73039957
136MP0001145_abnormal_male_reproductive0.72901594
137MP0002098_abnormal_vibrissa_morphology0.72505790
138MP0001243_abnormal_dermal_layer0.71555298
139MP0002751_abnormal_autonomic_nervous0.71235117
140MP0001188_hyperpigmentation0.70807421
141MP0001765_abnormal_ion_homeostasis0.70267544
142MP0000653_abnormal_sex_gland0.70256493
143MP0010307_abnormal_tumor_latency0.70098731
144MP0002089_abnormal_postnatal_growth/wei0.69441441
145MP0002075_abnormal_coat/hair_pigmentati0.69373114
146MP0005310_abnormal_salivary_gland0.68550528
147MP0005395_other_phenotype0.68163611
148MP0005535_abnormal_body_temperature0.67972423
149MP0000631_abnormal_neuroendocrine_gland0.67898278
150MP0005275_abnormal_skin_tensile0.67698260
151MP0003861_abnormal_nervous_system0.66416706
152MP0000358_abnormal_cell_content/0.66403746
153MP0004484_altered_response_of0.65523425
154MP0004233_abnormal_muscle_weight0.64670167
155MP0003937_abnormal_limbs/digits/tail_de0.63927208
156MP0004145_abnormal_muscle_electrophysio0.62980086
157MP0000747_muscle_weakness0.62382804
158MP0003690_abnormal_glial_cell0.62378876
159MP0005389_reproductive_system_phenotype0.61551652
160MP0001177_atelectasis0.61175480
161MP0002269_muscular_atrophy0.59227809
162MP0005248_abnormal_Harderian_gland0.57976185
163MP0001293_anophthalmia0.57812431
164MP0003075_altered_response_to0.57273855
165MP0001119_abnormal_female_reproductive0.57122328
166MP0003938_abnormal_ear_development0.56347560
167MP0001664_abnormal_digestion0.54739237
168MP0000428_abnormal_craniofacial_morphol0.53903099
169MP0000751_myopathy0.53838544
170MP0003632_abnormal_nervous_system0.52255382
171MP0004215_abnormal_myocardial_fiber0.51996951
172MP0008995_early_reproductive_senescence0.51528991
173MP0003699_abnormal_female_reproductive0.50239862
174MP0001299_abnormal_eye_distance/0.49660222

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.95882912
2Abnormal respiratory motile cilium physiology (HP:0012261)9.06008035
3Abnormal ciliary motility (HP:0012262)8.45814804
4Dynein arm defect of respiratory motile cilia (HP:0012255)8.08121203
5Absent/shortened dynein arms (HP:0200106)8.08121203
6Abnormal respiratory motile cilium morphology (HP:0005938)7.51142947
7Abnormal respiratory epithelium morphology (HP:0012253)7.51142947
8Rhinitis (HP:0012384)7.49666520
9Chronic bronchitis (HP:0004469)5.40132630
10Focal motor seizures (HP:0011153)5.25769835
11Acanthocytosis (HP:0001927)4.50090407
12Bronchiectasis (HP:0002110)4.19532899
13Carpal bone hypoplasia (HP:0001498)4.08931711
14Epileptic encephalopathy (HP:0200134)3.87837037
15Atonic seizures (HP:0010819)3.79751606
16Focal seizures (HP:0007359)3.74733297
17Myokymia (HP:0002411)3.73975537
18Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)3.72334718
19Infertility (HP:0000789)3.68621027
20Hyperventilation (HP:0002883)3.62037960
21Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)3.35943412
22Medial flaring of the eyebrow (HP:0010747)3.33454897
23Gait imbalance (HP:0002141)3.23788162
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.21944948
25Parakeratosis (HP:0001036)3.18457913
26Abnormality of the distal phalanges of the toes (HP:0010182)3.11139577
27Nephronophthisis (HP:0000090)3.10717956
28Nasal polyposis (HP:0100582)3.09469218
29Febrile seizures (HP:0002373)3.08461865
30Congenital primary aphakia (HP:0007707)3.07567172
31Pancreatic fibrosis (HP:0100732)3.01604728
32Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.94090299
33Absence seizures (HP:0002121)2.93574416
34Abnormality of midbrain morphology (HP:0002418)2.91953003
35Molar tooth sign on MRI (HP:0002419)2.91953003
36Congenital stationary night blindness (HP:0007642)2.89029743
37Chronic sinusitis (HP:0011109)2.87273003
38Visual hallucinations (HP:0002367)2.87014062
39Abnormal rod and cone electroretinograms (HP:0008323)2.82571502
40Nephrogenic diabetes insipidus (HP:0009806)2.80735297
41Premature skin wrinkling (HP:0100678)2.76491344
42Albinism (HP:0001022)2.72729166
43Bronchitis (HP:0012387)2.69849520
44Abnormality of the epiphyses of the hand (HP:0005924)2.69705033
45Dialeptic seizures (HP:0011146)2.66426735
46Epidermoid cyst (HP:0200040)2.66422580
47Progressive cerebellar ataxia (HP:0002073)2.65861732
48Abnormality of the lower motor neuron (HP:0002366)2.64877121
49Sclerocornea (HP:0000647)2.59534751
50Glucose intolerance (HP:0000833)2.56227298
51Congenital, generalized hypertrichosis (HP:0004540)2.54824197
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.54792489
53Axonal loss (HP:0003447)2.51009828
54Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.50339367
55Broad-based gait (HP:0002136)2.46201931
56Genital tract atresia (HP:0001827)2.41666799
57Barrel-shaped chest (HP:0001552)2.38641563
58Abnormality of the nasal mucosa (HP:0000433)2.36469889
59Abnormality of the costochondral junction (HP:0000919)2.35387188
60Poor coordination (HP:0002370)2.35058464
61Distal arthrogryposis (HP:0005684)2.35040278
62Generalized tonic-clonic seizures (HP:0002069)2.34347032
63Hypoplasia of the pons (HP:0012110)2.30787972
64Retinal dysplasia (HP:0007973)2.28224559
65Recurrent sinusitis (HP:0011108)2.27418400
66Postaxial hand polydactyly (HP:0001162)2.27031905
67Erythroderma (HP:0001019)2.26674143
68Abnormality of the renal cortex (HP:0011035)2.25782611
69Attenuation of retinal blood vessels (HP:0007843)2.24155517
70Vaginal atresia (HP:0000148)2.24110214
71Supernumerary spleens (HP:0009799)2.23239223
72Abnormality of the renal medulla (HP:0100957)2.22692362
73Abnormality of the fingertips (HP:0001211)2.22541297
74Amelogenesis imperfecta (HP:0000705)2.21933453
75Median cleft lip (HP:0000161)2.20941620
76Genetic anticipation (HP:0003743)2.20665330
77Hypoplasia of the odontoid process (HP:0003311)2.19997562
78Anencephaly (HP:0002323)2.19074226
79Broad alveolar ridges (HP:0000187)2.18393279
80Short tibia (HP:0005736)2.17091257
81Hypoalphalipoproteinemia (HP:0003233)2.14689852
82Gaze-evoked nystagmus (HP:0000640)2.14599359
83Adrenal hypoplasia (HP:0000835)2.11055484
84Aplasia/Hypoplasia of the fovea (HP:0008060)2.09821786
85Hypoplasia of the fovea (HP:0007750)2.09821786
86Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.08513885
87Cystic liver disease (HP:0006706)2.07892022
88Sensory axonal neuropathy (HP:0003390)2.07507760
89Postaxial foot polydactyly (HP:0001830)2.07232155
90Sparse eyelashes (HP:0000653)2.06783836
91Supranuclear gaze palsy (HP:0000605)2.06090145
92Impaired vibration sensation in the lower limbs (HP:0002166)2.05145510
93Tubular atrophy (HP:0000092)2.04205052
94Abnormal glucose tolerance (HP:0001952)2.03241322
95Fibular hypoplasia (HP:0003038)2.02762171
96Amblyopia (HP:0000646)2.02371543
97Severe visual impairment (HP:0001141)2.01540186
98Tubulointerstitial nephritis (HP:0001970)2.01402474
99IgM deficiency (HP:0002850)2.01318265
100Intellectual disability, moderate (HP:0002342)2.00728811
101Abnormality of the pons (HP:0007361)1.99939471
102Recurrent otitis media (HP:0000403)1.99846044
103Nasal speech (HP:0001611)1.99588192
104Aplasia/Hypoplasia of the sternum (HP:0006714)1.97445258
105Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97078942
106Truncal ataxia (HP:0002078)1.95322014
107Impaired smooth pursuit (HP:0007772)1.94734215
108True hermaphroditism (HP:0010459)1.93040156
109Partial agenesis of the corpus callosum (HP:0001338)1.92560795
110Specific learning disability (HP:0001328)1.92340398
111Abnormal eating behavior (HP:0100738)1.88886492
112Cerebral inclusion bodies (HP:0100314)1.87170841
113Abnormality of ocular smooth pursuit (HP:0000617)1.87116780
114Aplasia/Hypoplasia of the hallux (HP:0008362)1.85936870
115Urinary bladder sphincter dysfunction (HP:0002839)1.85844572
116Hypolipoproteinemia (HP:0010981)1.85306788
117Hyperlipoproteinemia (HP:0010980)1.85207529
118Inability to walk (HP:0002540)1.84074870
119Aplasia/Hypoplasia of the earlobes (HP:0009906)1.82223073
120Abnormal drinking behavior (HP:0030082)1.81523984
121Polydipsia (HP:0001959)1.81523984
122Oculomotor apraxia (HP:0000657)1.80102356
123Drooling (HP:0002307)1.79163647
124Excessive salivation (HP:0003781)1.79163647
125Short nail (HP:0001799)1.79078003
126Dysmetria (HP:0001310)1.78636872
127Azoospermia (HP:0000027)1.77490779
128Aplasia/Hypoplasia of the lens (HP:0008063)1.77364153
129Absent speech (HP:0001344)1.77349189
130Follicular hyperkeratosis (HP:0007502)1.77086527
131Action tremor (HP:0002345)1.76968505
132Submucous cleft hard palate (HP:0000176)1.76917255
133Diplopia (HP:0000651)1.76691812
134Abnormality of binocular vision (HP:0011514)1.76691812
135Abnormality of dentin (HP:0010299)1.76398350
136Decreased central vision (HP:0007663)1.76021300
137Abnormality of the nasal septum (HP:0000419)1.75841260
138Hyperthyroidism (HP:0000836)1.75110953
139Papilledema (HP:0001085)1.75017465
140Poikilocytosis (HP:0004447)1.74988820
141Poor eye contact (HP:0000817)1.74450683
142Anosmia (HP:0000458)1.74108154
143Chronic hepatic failure (HP:0100626)1.73276044
144Long nose (HP:0003189)1.73129573
145Abnormality of the alveolar ridges (HP:0006477)1.72650618
146Redundant skin (HP:0001582)1.72483405
147Bell-shaped thorax (HP:0001591)1.72379519
148Anxiety (HP:0000739)1.71587267
149Bifid tongue (HP:0010297)1.70554606
150B lymphocytopenia (HP:0010976)1.70240465
151Chorioretinal atrophy (HP:0000533)1.70005475
152Depression (HP:0000716)1.69022261
153Neurofibrillary tangles (HP:0002185)1.68777446
154Delusions (HP:0000746)1.67435691
155Ankle clonus (HP:0011448)1.67207799
156Amyotrophic lateral sclerosis (HP:0007354)1.67111888
157Congenital hepatic fibrosis (HP:0002612)1.66327948
158Aplasia/Hypoplasia of the tongue (HP:0010295)1.63755586
159Central scotoma (HP:0000603)1.63378560
160Impaired vibratory sensation (HP:0002495)1.63313285
161Abnormality of macular pigmentation (HP:0008002)1.62164271
162Dysdiadochokinesis (HP:0002075)1.61328291
163Hemiparesis (HP:0001269)1.60312873
164Abnormality of permanent molar morphology (HP:0011071)1.58726827
165Abnormality of the dental root (HP:0006486)1.58726827
166Taurodontia (HP:0000679)1.58726827
167Postural instability (HP:0002172)1.55889113
168Pancreatic cysts (HP:0001737)1.55488610
169Protruding tongue (HP:0010808)1.54712539
170Occipital encephalocele (HP:0002085)1.53664687
171Termporal pattern (HP:0011008)1.52852519
172Insidious onset (HP:0003587)1.52852519
173Facial cleft (HP:0002006)1.51000497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.41309099
2EPHA44.02172208
3NTRK33.57153482
4CASK3.51356661
5PDK43.47903397
6PDK33.47903397
7EIF2AK33.43972949
8PNCK3.41752127
9ACVR1B3.40685230
10DAPK23.08659605
11MAP2K72.93498938
12MAP3K122.87974660
13MAP3K92.86187519
14MAP3K42.79254886
15PLK42.65359930
16MAP4K22.38822805
17FRK2.32081927
18DAPK12.26970994
19ARAF2.13495710
20MAPK152.11544248
21PINK12.10892775
22MINK12.01962923
23PDK22.01675750
24PTK2B1.95200760
25PLK21.91948951
26CDK191.83701865
27PRKD31.81815670
28MAP2K41.81320157
29MAP2K11.79181969
30NTRK21.78216690
31PRPF4B1.75341263
32GRK11.73961470
33CCNB11.65834237
34RIPK41.63715848
35MARK11.62818955
36PRKCI1.57576221
37MST1R1.49055321
38PAK61.44197636
39BMPR1B1.41194087
40STK38L1.38175891
41SCYL21.34602907
42INSRR1.32732910
43PRKCG1.30340592
44MKNK21.29199638
45GRK51.28468773
46OXSR11.27701757
47BRD41.27156295
48MAP2K61.23224314
49ZAK1.22881946
50ERBB31.22099734
51MAPK131.18959202
52KSR11.18875113
53CDK51.18585303
54WNK11.15510273
55MET1.15498650
56STK381.11163564
57CAMK2B1.10338883
58MUSK1.06788658
59BRAF1.06649165
60MAP2K21.03624078
61STK391.02314882
62MAPKAPK31.02218985
63KSR21.02062845
64CAMKK11.00490468
65BRSK21.00453961
66CAMK2A0.98272780
67BMPR20.97310899
68PBK0.94934326
69TNIK0.93476703
70LMTK20.90545933
71WNK30.86143383
72FES0.85646709
73PHKG10.82345220
74PHKG20.82345220
75FGFR10.79066337
76TYRO30.78938838
77ICK0.77190405
78NTRK10.76550480
79TRPM70.75269196
80FGR0.75242584
81SIK20.74533066
82PDK10.74433435
83PTK20.73425670
84AKT30.68909446
85ADRBK10.68114999
86SIK30.65318516
87RAF10.64105100
88MAP3K130.63037353
89PAK30.62033784
90TNK20.60887554
91CDK180.60882124
92NEK90.59659974
93JAK10.59486072
94SGK4940.58413740
95SGK2230.58413740
96WNK40.56425453
97CAMK2D0.56099035
98AKT20.56071387
99CAMK2G0.55627171
100CDK150.54432715
101STK110.54216553
102CDK140.53762757
103CAMK10.51921570
104MELK0.51529074
105MAP3K20.50895219
106EIF2AK10.49552071
107PDPK10.48201628
108SGK30.47845806
109STK100.47572663
110TESK10.47239481
111MYLK0.47194736
112MAP2K30.47128781
113CSNK1G20.47069645
114DYRK1A0.47025146
115ERBB20.46511019
116DAPK30.46033626
117CHUK0.45327873
118LATS20.45266604
119OBSCN0.45195469
120GRK60.44204001
121CDK11A0.43850269
122MAP3K60.43417300
123SGK20.43321343
124ROCK20.42710558
125CAMKK20.41377254
126DYRK30.40806796
127EIF2AK20.40655428
128DDR20.40471140
129TSSK60.39320712
130NME10.38974618
131TXK0.38668516
132EEF2K0.37763001
133NEK60.35845726
134PLK10.35305510
135LATS10.35038417
136MAP3K50.34272903
137PRKCE0.34001938
138CSNK1G10.33981819
139IKBKB0.33653518
140PRKCZ0.33416615
141SGK10.33253676
142MAPK100.32103786
143CHEK20.30679017
144BCR0.30145255
145MAP3K10.29670983
146CDK30.29508827
147IKBKE0.28908199
148RPS6KB10.28550403
149RPS6KA30.27552137
150FER0.27477278
151FYN0.27258993
152MKNK10.26847969
153SRPK10.26469431
154UHMK10.26462783
155EPHA20.25257836
156CDK70.24512732
157PRKCH0.23714098
158PLK30.23668759
159MARK20.23636646
160PRKCQ0.23390679
161PRKAA10.23066431
162PIK3CG0.22789518
163MAPK70.22776865
164GRK70.21946374
165TAOK10.21207364
166WEE10.21123171
167IGF1R0.20449600
168CHEK10.19813222
169TRIM280.19574779
170ABL10.18762056
171CSNK1A1L0.18263453
172AURKA0.17444711

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.53141965
2Nicotine addiction_Homo sapiens_hsa050333.73514777
3Fanconi anemia pathway_Homo sapiens_hsa034603.61528380
4Synaptic vesicle cycle_Homo sapiens_hsa047213.37780889
5Protein export_Homo sapiens_hsa030603.37030261
6Nitrogen metabolism_Homo sapiens_hsa009103.15065010
7Amphetamine addiction_Homo sapiens_hsa050312.90680879
8Long-term potentiation_Homo sapiens_hsa047202.77327140
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67920525
10Circadian entrainment_Homo sapiens_hsa047132.66959015
11Morphine addiction_Homo sapiens_hsa050322.55674547
12Glutamatergic synapse_Homo sapiens_hsa047242.53080389
13Homologous recombination_Homo sapiens_hsa034402.49409344
14GABAergic synapse_Homo sapiens_hsa047272.35163315
15Collecting duct acid secretion_Homo sapiens_hsa049662.34257223
16Selenocompound metabolism_Homo sapiens_hsa004502.30730379
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.21563199
18Dopaminergic synapse_Homo sapiens_hsa047282.18572077
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.08353143
20Salivary secretion_Homo sapiens_hsa049702.07231910
21Taste transduction_Homo sapiens_hsa047422.03298858
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00127819
23Insulin secretion_Homo sapiens_hsa049111.96116287
24Gastric acid secretion_Homo sapiens_hsa049711.86455854
25Renin secretion_Homo sapiens_hsa049241.86203185
26Folate biosynthesis_Homo sapiens_hsa007901.76936066
27Calcium signaling pathway_Homo sapiens_hsa040201.70901200
28p53 signaling pathway_Homo sapiens_hsa041151.69213443
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68037939
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64444022
31One carbon pool by folate_Homo sapiens_hsa006701.57418210
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56472308
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54914168
34Oxytocin signaling pathway_Homo sapiens_hsa049211.54303178
35Serotonergic synapse_Homo sapiens_hsa047261.53736635
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53207104
37Legionellosis_Homo sapiens_hsa051341.53015334
38Cholinergic synapse_Homo sapiens_hsa047251.52000575
39Peroxisome_Homo sapiens_hsa041461.42579130
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36183787
41Sulfur metabolism_Homo sapiens_hsa009201.34863061
42Phototransduction_Homo sapiens_hsa047441.34061558
43Vibrio cholerae infection_Homo sapiens_hsa051101.33635524
44Long-term depression_Homo sapiens_hsa047301.32538027
45Cocaine addiction_Homo sapiens_hsa050301.32003544
46Oocyte meiosis_Homo sapiens_hsa041141.31537183
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30998103
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30725732
49cAMP signaling pathway_Homo sapiens_hsa040241.30122481
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29111671
51GnRH signaling pathway_Homo sapiens_hsa049121.27665126
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.27209088
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.27195155
54N-Glycan biosynthesis_Homo sapiens_hsa005101.25820254
55Estrogen signaling pathway_Homo sapiens_hsa049151.25383101
56Vitamin B6 metabolism_Homo sapiens_hsa007501.23989159
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.23616633
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20584186
59RNA polymerase_Homo sapiens_hsa030201.19678231
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18226153
61Chemical carcinogenesis_Homo sapiens_hsa052041.15309398
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13532079
63cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12291196
64Basal transcription factors_Homo sapiens_hsa030221.11659128
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11467030
66Steroid hormone biosynthesis_Homo sapiens_hsa001401.07084117
67TNF signaling pathway_Homo sapiens_hsa046681.07048459
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06804311
69Huntingtons disease_Homo sapiens_hsa050161.06736907
70ABC transporters_Homo sapiens_hsa020101.06461792
71Dorso-ventral axis formation_Homo sapiens_hsa043201.06206206
72Sulfur relay system_Homo sapiens_hsa041221.05989967
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04406633
74Mismatch repair_Homo sapiens_hsa034301.03378043
75Tryptophan metabolism_Homo sapiens_hsa003801.02978401
76Glucagon signaling pathway_Homo sapiens_hsa049221.02891098
77Gap junction_Homo sapiens_hsa045401.02040192
78Glycerolipid metabolism_Homo sapiens_hsa005611.00479899
79RNA transport_Homo sapiens_hsa030130.99999319
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99694709
81Systemic lupus erythematosus_Homo sapiens_hsa053220.96967957
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95861951
83Retinol metabolism_Homo sapiens_hsa008300.91649149
84Melanogenesis_Homo sapiens_hsa049160.90448003
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.89325957
86Mineral absorption_Homo sapiens_hsa049780.88968566
87Nucleotide excision repair_Homo sapiens_hsa034200.87524350
88Axon guidance_Homo sapiens_hsa043600.86839301
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84673928
90Cardiac muscle contraction_Homo sapiens_hsa042600.84049810
91Glioma_Homo sapiens_hsa052140.83375296
92Sphingolipid metabolism_Homo sapiens_hsa006000.81799464
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80768239
94Thyroid hormone synthesis_Homo sapiens_hsa049180.80035010
95ErbB signaling pathway_Homo sapiens_hsa040120.78797981
96Alzheimers disease_Homo sapiens_hsa050100.78451550
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78189316
98TGF-beta signaling pathway_Homo sapiens_hsa043500.77068497
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74961906
100Oxidative phosphorylation_Homo sapiens_hsa001900.72868089
101Purine metabolism_Homo sapiens_hsa002300.72224993
102Butanoate metabolism_Homo sapiens_hsa006500.69963357
103VEGF signaling pathway_Homo sapiens_hsa043700.69560044
104Pyruvate metabolism_Homo sapiens_hsa006200.67980247
105Type II diabetes mellitus_Homo sapiens_hsa049300.65771072
106Caffeine metabolism_Homo sapiens_hsa002320.64714971
107Vitamin digestion and absorption_Homo sapiens_hsa049770.62005001
108Fat digestion and absorption_Homo sapiens_hsa049750.60626083
109Pancreatic secretion_Homo sapiens_hsa049720.60251523
110RNA degradation_Homo sapiens_hsa030180.59787799
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59731235
112ECM-receptor interaction_Homo sapiens_hsa045120.59578226
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58685029
114Proteasome_Homo sapiens_hsa030500.58425790
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.58134675
116MAPK signaling pathway_Homo sapiens_hsa040100.57635649
117Cell cycle_Homo sapiens_hsa041100.56731119
118Propanoate metabolism_Homo sapiens_hsa006400.56350761
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55078111
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54315855
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53435625
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52783761
123Fatty acid biosynthesis_Homo sapiens_hsa000610.52746204
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52347018
125Ras signaling pathway_Homo sapiens_hsa040140.52307117
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51747653
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.51247749
128Choline metabolism in cancer_Homo sapiens_hsa052310.49284642
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48121884
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47695376
131Alcoholism_Homo sapiens_hsa050340.47443663
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.47437848
133Inositol phosphate metabolism_Homo sapiens_hsa005620.44787395
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44437084
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44379439
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.43733784
137Lysine degradation_Homo sapiens_hsa003100.43585120
138Rheumatoid arthritis_Homo sapiens_hsa053230.42985243
139Metabolic pathways_Homo sapiens_hsa011000.42536651
140Wnt signaling pathway_Homo sapiens_hsa043100.40418275
141Thyroid cancer_Homo sapiens_hsa052160.39364783
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38978485
143Bile secretion_Homo sapiens_hsa049760.38889347
144Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38243495
145Parkinsons disease_Homo sapiens_hsa050120.38239903
146PPAR signaling pathway_Homo sapiens_hsa033200.38124334
147Intestinal immune network for IgA production_Homo sapiens_hsa046720.38039548
148Ovarian steroidogenesis_Homo sapiens_hsa049130.38023684
149Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37937530
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37716344
151Linoleic acid metabolism_Homo sapiens_hsa005910.35471651
152Prion diseases_Homo sapiens_hsa050200.34998764
153Small cell lung cancer_Homo sapiens_hsa052220.34803336
154Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33928198
155Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33843954
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.33254684
157Neurotrophin signaling pathway_Homo sapiens_hsa047220.31779453
158Rap1 signaling pathway_Homo sapiens_hsa040150.28539476
159Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27131391
160mTOR signaling pathway_Homo sapiens_hsa041500.26705763
161Dilated cardiomyopathy_Homo sapiens_hsa054140.26564773
162Insulin signaling pathway_Homo sapiens_hsa049100.26562815
163Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26527978
164Endocytosis_Homo sapiens_hsa041440.26120980
165T cell receptor signaling pathway_Homo sapiens_hsa046600.25755881
166Regulation of autophagy_Homo sapiens_hsa041400.25252954
167Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25069268
168Circadian rhythm_Homo sapiens_hsa047100.24238272
169Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23228021
170Ether lipid metabolism_Homo sapiens_hsa005650.22923601

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