CDKN1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)5.08723994
2regulation of vitamin metabolic process (GO:0030656)4.14568541
3wound healing, spreading of epidermal cells (GO:0035313)4.03624959
4cell adhesion mediated by integrin (GO:0033627)3.71009741
5positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.67089454
6activation of MAPKKK activity (GO:0000185)3.65254524
7adhesion of symbiont to host cell (GO:0044650)3.64319371
8virion attachment to host cell (GO:0019062)3.64319371
9protein localization to endosome (GO:0036010)3.64094051
10positive regulation by symbiont of host defense response (GO:0052509)3.62247738
11modulation by symbiont of host defense response (GO:0052031)3.62247738
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.62247738
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.62247738
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.62247738
15modulation by symbiont of host immune response (GO:0052553)3.62247738
16cellular response to interferon-alpha (GO:0035457)3.58820425
17positive regulation of interferon-alpha production (GO:0032727)3.52475021
18regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.50786976
19regulation of cytokine secretion involved in immune response (GO:0002739)3.47959894
20glycosphingolipid catabolic process (GO:0046479)3.47650612
21neutrophil activation involved in immune response (GO:0002283)3.41614923
22regulation of chronic inflammatory response (GO:0002676)3.39111392
23regulation of interferon-alpha production (GO:0032647)3.33982009
24regulation of mononuclear cell migration (GO:0071675)3.33255437
25response to muramyl dipeptide (GO:0032495)3.32889822
26negative regulation of interleukin-12 production (GO:0032695)3.27737885
27response to peptidoglycan (GO:0032494)3.27266927
28natural killer cell mediated cytotoxicity (GO:0042267)3.25386523
29natural killer cell mediated immunity (GO:0002228)3.25386523
30adhesion of symbiont to host (GO:0044406)3.23081682
31negative regulation of nitric oxide biosynthetic process (GO:0045019)3.23020631
32oligosaccharide catabolic process (GO:0009313)3.20496202
33branching involved in labyrinthine layer morphogenesis (GO:0060670)3.18818207
34glycolipid catabolic process (GO:0019377)3.16151642
35regulation of fever generation (GO:0031620)3.15870519
36regulation of T-helper 1 cell differentiation (GO:0045625)3.15804851
37negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.15345826
38wound healing, spreading of cells (GO:0044319)3.14582671
39positive regulation of natural killer cell differentiation (GO:0032825)3.14256940
40positive regulation of chemokine biosynthetic process (GO:0045080)3.12175199
41decidualization (GO:0046697)3.11614884
42regulation of dendritic cell antigen processing and presentation (GO:0002604)2.99394934
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.98831821
44low-density lipoprotein particle clearance (GO:0034383)2.97008684
45positive regulation of endothelial cell apoptotic process (GO:2000353)2.95885694
46endodermal cell differentiation (GO:0035987)2.92530555
47regulation of integrin activation (GO:0033623)2.90760399
48positive regulation of monocyte chemotaxis (GO:0090026)2.88889118
49response to interferon-alpha (GO:0035455)2.88591759
50monocyte chemotaxis (GO:0002548)2.83749489
51chondrocyte proliferation (GO:0035988)2.82555324
52immunoglobulin mediated immune response (GO:0016064)2.81337801
53lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79864557
54response to type I interferon (GO:0034340)2.79539001
55ceramide catabolic process (GO:0046514)2.79010198
56barbed-end actin filament capping (GO:0051016)2.78584375
57regulation of interleukin-12 biosynthetic process (GO:0045075)2.77203011
58cellular response to type I interferon (GO:0071357)2.77182930
59type I interferon signaling pathway (GO:0060337)2.77182930
60regulation of interferon-beta biosynthetic process (GO:0045357)2.76744749
61membrane lipid catabolic process (GO:0046466)2.76511586
62regulation of protein heterodimerization activity (GO:0043497)2.76479094
63apoptotic cell clearance (GO:0043277)2.74643462
64positive regulation of p38MAPK cascade (GO:1900745)2.74625787
65regulation of monocyte chemotaxis (GO:0090025)2.71882333
66regulation of nitric oxide biosynthetic process (GO:0045428)2.71278844
67Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69451510
68negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.67601749
69sphingolipid catabolic process (GO:0030149)2.67241913
70cellular response to virus (GO:0098586)2.66923569
71positive regulation of interferon-beta production (GO:0032728)2.66703241
72regulation of macrophage cytokine production (GO:0010935)2.65835841
73regulation of T-helper 2 cell differentiation (GO:0045628)2.64141890
74positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.63646779
75skin morphogenesis (GO:0043589)2.63090513
76germinal center formation (GO:0002467)2.61866795
77substrate-dependent cell migration (GO:0006929)2.60076776
78positive regulation of protein oligomerization (GO:0032461)2.59967645
79stress fiber assembly (GO:0043149)2.59060673
80granulocyte activation (GO:0036230)2.58511230
81COPI coating of Golgi vesicle (GO:0048205)2.58305439
82Golgi transport vesicle coating (GO:0048200)2.58305439
83myeloid cell homeostasis (GO:0002262)2.57995512
84response to laminar fluid shear stress (GO:0034616)2.57414750
85interferon-gamma-mediated signaling pathway (GO:0060333)2.57178138
86negative regulation of fatty acid transport (GO:2000192)2.56827943
87regulation of cholesterol storage (GO:0010885)2.56675911
88regulation of podosome assembly (GO:0071801)2.55696916
89negative regulation of lipid storage (GO:0010888)2.54967644
90cellular response to lipopolysaccharide (GO:0071222)2.54052017
91cellular response to thyroid hormone stimulus (GO:0097067)2.53860068
92positive regulation of interleukin-12 production (GO:0032735)2.53789557
93dendritic cell differentiation (GO:0097028)2.52671198
94positive regulation of type 2 immune response (GO:0002830)2.52147017
95NIK/NF-kappaB signaling (GO:0038061)2.52002650
96positive regulation of nitric oxide biosynthetic process (GO:0045429)2.51498091
97positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.51267146
98macrophage activation involved in immune response (GO:0002281)2.49268336
99T cell apoptotic process (GO:0070231)2.48590257
100regulation of heterotypic cell-cell adhesion (GO:0034114)2.48449861
101eosinophil chemotaxis (GO:0048245)2.48275430
102endocytic recycling (GO:0032456)2.48246538
103regulation of early endosome to late endosome transport (GO:2000641)2.46185336
104regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46138307
105myeloid dendritic cell differentiation (GO:0043011)2.45689223
106regulation of integrin-mediated signaling pathway (GO:2001044)2.45254015
107regulation of immunoglobulin secretion (GO:0051023)2.45128842
108establishment of endothelial barrier (GO:0061028)2.44807602
109regulation of heat generation (GO:0031650)2.44801241
110positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.43896391
111T-helper 1 type immune response (GO:0042088)2.43753609
112pinocytosis (GO:0006907)2.43484532
113amino sugar catabolic process (GO:0046348)2.42719743
114cellular response to molecule of bacterial origin (GO:0071219)2.42245653
115positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.41779156
116regulation of antigen processing and presentation (GO:0002577)2.41111481
117positive regulation of NF-kappaB import into nucleus (GO:0042346)2.40481391
118hyaluronan catabolic process (GO:0030214)2.39394555
119basement membrane organization (GO:0071711)2.39238237
120positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.39103918
121neutrophil activation (GO:0042119)2.38710766
122negative regulation of cytokine production involved in immune response (GO:0002719)2.38601988
123response to magnesium ion (GO:0032026)2.37854747
124negative regulation of viral genome replication (GO:0045071)2.37845462
125myeloid dendritic cell activation (GO:0001773)2.37346270
126regulation of apoptotic process involved in morphogenesis (GO:1902337)2.36256032
127cellular response to arsenic-containing substance (GO:0071243)2.36252360
128positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.36027089
129cellular response to vitamin (GO:0071295)2.36023966
130positive regulation of macrophage cytokine production (GO:0060907)2.36009930
131glial cell migration (GO:0008347)2.34972021
132sphingosine metabolic process (GO:0006670)2.34882082
133regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.34708671
134B cell mediated immunity (GO:0019724)2.33659392
135response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.33189088
136response to host immune response (GO:0052572)2.33189088
137collagen fibril organization (GO:0030199)2.33070790
138regulation of chemokine biosynthetic process (GO:0045073)2.32397847
139response to protozoan (GO:0001562)2.32016915
140hemidesmosome assembly (GO:0031581)2.31782816
141regulation of type 2 immune response (GO:0002828)2.31294721
142positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.31218078
143positive regulation of lymphocyte apoptotic process (GO:0070230)2.30337151
144regulation of membrane protein ectodomain proteolysis (GO:0051043)2.29958632
145chronic inflammatory response (GO:0002544)2.29542910
146membrane raft organization (GO:0031579)2.29116939
147positive regulation of heat generation (GO:0031652)2.28860500
148positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.28045052
149activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.27784463
150positive regulation of interleukin-6 production (GO:0032755)2.27581393
151regulation of interleukin-6 production (GO:0032675)2.27258679
152positive regulation of leukocyte apoptotic process (GO:2000108)2.26999034
153lymphocyte chemotaxis (GO:0048247)2.26575063
154positive regulation of antigen processing and presentation (GO:0002579)2.26569201
155growth hormone receptor signaling pathway (GO:0060396)2.26330033
156response to vitamin D (GO:0033280)2.26046566
157regulation of interferon-gamma biosynthetic process (GO:0045072)2.24928049
158modulation by symbiont of host cellular process (GO:0044068)2.23601261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TP63_17297297_ChIP-ChIP_HaCaT_Human7.11700367
2* TRIM28_21343339_ChIP-Seq_HEK293_Human3.91852836
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.85416849
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.81099484
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.60834977
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.57764555
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.45538497
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.42306807
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.20636458
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.06092756
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.78388359
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.47075308
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36997431
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33250482
15* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.31372037
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29343956
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28984308
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22314224
19* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.12878759
20* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.05026244
21* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.00309941
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.97435676
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97105837
24* ELK3_25401928_ChIP-Seq_HUVEC_Human1.95841653
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.86744273
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84625487
27* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.84082630
28* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.84082630
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79058500
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74602364
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72723140
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.69133150
33* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65323844
34* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.64804696
35* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62189230
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.57343930
37* CLOCK_20551151_ChIP-Seq_293T_Human1.56558717
38SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55047994
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51459558
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49326884
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.48436603
42CJUN_26792858_Chip-Seq_BT549_Human1.48230353
43* ATF3_27146783_Chip-Seq_COLON_Human1.46561774
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45660648
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45293970
46JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44650468
47SOX2_20726797_ChIP-Seq_SW620_Human1.44158978
48* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.42178480
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.39373917
50* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38030024
51JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37365884
52RACK7_27058665_Chip-Seq_MCF-7_Human1.36460457
53MAF_26560356_Chip-Seq_TH1_Human1.35650737
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.33762253
55* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32127069
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31687587
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31637692
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31034041
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28219041
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27455367
61* UBF1/2_26484160_Chip-Seq_HMECs_Human1.26805454
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26197090
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23466552
64* VDR_24763502_ChIP-Seq_THP-1_Human1.22222569
65* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19070810
66RXR_22158963_ChIP-Seq_LIVER_Mouse1.18932804
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18700421
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18273903
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18105668
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17861321
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16723624
72* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16512826
73BRD4_25478319_ChIP-Seq_HGPS_Human1.15362154
74* KDM2B_26808549_Chip-Seq_K562_Human1.15286597
75* TCF7_22412390_ChIP-Seq_EML_Mouse1.15046378
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14926364
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11079326
78* SPI1_23547873_ChIP-Seq_NB4_Human1.11011765
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.10824503
80* KDM2B_26808549_Chip-Seq_DND41_Human1.10774431
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09842383
82CDX2_20551321_ChIP-Seq_CACO-2_Human1.09746459
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08371282
84* VDR_21846776_ChIP-Seq_THP-1_Human1.07699789
85* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07602956
86* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07073451
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07052323
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06955648
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06827728
90* VDR_24787735_ChIP-Seq_THP-1_Human1.05177178
91* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04667317
92* TP53_18474530_ChIP-ChIP_U2OS_Human1.04516380
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04153489
94* PU_27001747_Chip-Seq_BMDM_Mouse1.04060783
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03667760
96MYB_26560356_Chip-Seq_TH2_Human1.02382531
97SPI1_23127762_ChIP-Seq_K562_Human1.02182218
98* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02133404
99ZNF263_19887448_ChIP-Seq_K562_Human1.01862056
100SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01142758
101SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99756813
102CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99304865
103* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99125201
104SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99031039
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99021903
106* TP53_22127205_ChIP-Seq_IMR90_Human0.98417094
107LXR_22292898_ChIP-Seq_THP-1_Human0.97938914
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97934378
109* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97885378
110* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97885378
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97554661
112* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97018483
113* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96084761
114WT1_19549856_ChIP-ChIP_CCG9911_Human0.94621011
115GATA1_19941826_ChIP-Seq_K562_Human0.94129333
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93736045
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92126707
118TFEB_21752829_ChIP-Seq_HELA_Human0.92046769
119* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91214660
120LXR_22158963_ChIP-Seq_LIVER_Mouse0.89989469
121UTX_26944678_Chip-Seq_JUKART_Human0.88919696
122MYB_26560356_Chip-Seq_TH1_Human0.87438454
123* KLF5_25053715_ChIP-Seq_YYC3_Human0.86784188
124* NCOR1_26117541_ChIP-Seq_K562_Human0.85997529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.47178260
2MP0003303_peritoneal_inflammation3.19769971
3MP0003705_abnormal_hypodermis_morpholog2.76995823
4MP0005275_abnormal_skin_tensile2.73712618
5MP0003566_abnormal_cell_adhesion2.66540720
6* MP0003436_decreased_susceptibility_to2.45216603
7MP0002148_abnormal_hypersensitivity_rea2.43541151
8MP0010352_gastrointestinal_tract_polyps2.43261470
9MP0005451_abnormal_body_composition2.42630361
10MP0009785_altered_susceptibility_to2.28794468
11MP0001835_abnormal_antigen_presentation2.17291122
12MP0006082_CNS_inflammation2.14749891
13MP0003448_altered_tumor_morphology2.11495319
14MP0002139_abnormal_hepatobiliary_system2.07783668
15MP0005076_abnormal_cell_differentiation2.00390889
16MP0000685_abnormal_immune_system2.00306270
17MP0003091_abnormal_cell_migration1.99178092
18MP0005023_abnormal_wound_healing1.96428247
19MP0002877_abnormal_melanocyte_morpholog1.96123731
20MP0003300_gastrointestinal_ulcer1.95922730
21* MP0001533_abnormal_skeleton_physiology1.94071684
22MP0004510_myositis1.93858248
23MP0005623_abnormal_meninges_morphology1.92558055
24MP0005503_abnormal_tendon_morphology1.91420151
25MP0008004_abnormal_stomach_pH1.86559369
26MP0004947_skin_inflammation1.85792017
27* MP0005000_abnormal_immune_tolerance1.82528779
28MP0005058_abnormal_lysosome_morphology1.80097746
29MP0005387_immune_system_phenotype1.79997546
30MP0001790_abnormal_immune_system1.79997546
31MP0000604_amyloidosis1.78065871
32MP0003279_aneurysm1.77203516
33MP0003724_increased_susceptibility_to1.77123694
34* MP0002419_abnormal_innate_immunity1.73567797
35MP0009278_abnormal_bone_marrow1.69959786
36MP0003191_abnormal_cellular_cholesterol1.65991644
37MP0005025_abnormal_response_to1.62534820
38MP0000343_altered_response_to1.61383003
39MP0005257_abnormal_intraocular_pressure1.61379519
40* MP0003453_abnormal_keratinocyte_physiol1.60332630
41MP0002254_reproductive_system_inflammat1.58605150
42* MP0000858_altered_metastatic_potential1.54844266
43* MP0002452_abnormal_antigen_presenting1.54741618
44* MP0005390_skeleton_phenotype1.51309680
45* MP0000733_abnormal_muscle_development1.50910065
46MP0001348_abnormal_lacrimal_gland1.47975973
47MP0002405_respiratory_system_inflammati1.45772168
48MP0003828_pulmonary_edema1.44826136
49MP0004272_abnormal_basement_membrane1.43973903
50MP0001958_emphysema1.41998334
51MP0002332_abnormal_exercise_endurance1.41408459
52MP0002998_abnormal_bone_remodeling1.41399085
53MP0002060_abnormal_skin_morphology1.40943273
54MP0002933_joint_inflammation1.33051113
55MP0002796_impaired_skin_barrier1.32478966
56MP0000750_abnormal_muscle_regeneration1.31566351
57* MP0001542_abnormal_bone_strength1.30143390
58* MP0002723_abnormal_immune_serum1.29971687
59MP0009333_abnormal_splenocyte_physiolog1.29857141
60MP0001853_heart_inflammation1.27735297
61* MP0001800_abnormal_humoral_immune1.26161395
62MP0003329_amyloid_beta_deposits1.21500347
63* MP0010155_abnormal_intestine_physiology1.19990960
64MP0003045_fibrosis1.17747219
65* MP0001819_abnormal_immune_cell1.17226076
66MP0000767_abnormal_smooth_muscle1.16544739
67MP0005671_abnormal_response_to1.14092550
68* MP0002420_abnormal_adaptive_immunity1.13137852
69MP0002006_tumorigenesis1.13054502
70* MP0005508_abnormal_skeleton_morphology1.12831108
71MP0006054_spinal_hemorrhage1.09476463
72MP0001243_abnormal_dermal_layer1.08828648
73* MP0001845_abnormal_inflammatory_respons1.07129693
74MP0003656_abnormal_erythrocyte_physiolo1.05528547
75MP0008260_abnormal_autophagy1.05454215
76MP0005595_abnormal_vascular_smooth1.04943778
77MP0001216_abnormal_epidermal_layer1.04925619
78MP0001849_ear_inflammation1.04596128
79MP0005167_abnormal_blood-brain_barrier0.99928853
80MP0009840_abnormal_foam_cell0.99647892
81MP0005464_abnormal_platelet_physiology0.99387840
82MP0002295_abnormal_pulmonary_circulatio0.99244073
83MP0010234_abnormal_vibrissa_follicle0.97848874
84MP0003795_abnormal_bone_structure0.97736078
85MP0001851_eye_inflammation0.97485261
86MP0002166_altered_tumor_susceptibility0.91930983
87* MP0005164_abnormal_response_to0.91651585
88MP0010030_abnormal_orbit_morphology0.89970513
89* MP0005501_abnormal_skin_physiology0.87352684
90MP0001915_intracranial_hemorrhage0.85516509
91MP0003075_altered_response_to0.84753737
92MP0001346_abnormal_lacrimal_gland0.84230889
93* MP0009764_decreased_sensitivity_to0.83832187
94MP0002138_abnormal_hepatobiliary_system0.82137115
95MP0008469_abnormal_protein_level0.82033623
96MP0009384_cardiac_valve_regurgitation0.81993146
97MP0000249_abnormal_blood_vessel0.81901305
98MP0004883_abnormal_blood_vessel0.81737463
99* MP0001545_abnormal_hematopoietic_system0.81242555
100* MP0005397_hematopoietic_system_phenotyp0.81242555
101MP0004858_abnormal_nervous_system0.80815770
102* MP0009763_increased_sensitivity_to0.78121982
103MP0005310_abnormal_salivary_gland0.77551759
104MP0003172_abnormal_lysosome_physiology0.76905347
105MP0002896_abnormal_bone_mineralization0.76399444
106MP0005166_decreased_susceptibility_to0.75744251
107* MP0000627_abnormal_mammary_gland0.75514037
108MP0002277_abnormal_respiratory_mucosa0.74458365
109MP0003950_abnormal_plasma_membrane0.74085900
110MP0003634_abnormal_glial_cell0.72997610
111* MP0000716_abnormal_immune_system0.72848471
112* MP0010307_abnormal_tumor_latency0.72254083
113MP0009931_abnormal_skin_appearance0.71075212
114* MP0002113_abnormal_skeleton_development0.70864374
115MP0005165_increased_susceptibility_to0.69616229
116MP0000920_abnormal_myelination0.69475551
117MP0003183_abnormal_peptide_metabolism0.66896803
118* MP0008874_decreased_physiological_sensi0.66699875

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.92142318
2Abnormality of liposaccharide metabolism (HP:0010968)5.92142318
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.92142318
4Premature rupture of membranes (HP:0001788)4.78948445
5Protrusio acetabuli (HP:0003179)4.36600067
6Eczematoid dermatitis (HP:0000976)3.88930944
7Systemic lupus erythematosus (HP:0002725)3.76967637
8Loss of speech (HP:0002371)3.72635368
9Vertebral compression fractures (HP:0002953)3.66137114
10Nuclear cataract (HP:0100018)3.52167289
11Peritonitis (HP:0002586)3.49313743
12Abnormality of mucopolysaccharide metabolism (HP:0011020)3.30919546
13Abnormality of polysaccharide metabolism (HP:0011012)3.30919546
14Abnormality of glycosaminoglycan metabolism (HP:0004371)3.30919546
15Urinary glycosaminoglycan excretion (HP:0003541)3.28604132
16Mucopolysacchariduria (HP:0008155)3.28604132
17Recurrent abscess formation (HP:0002722)3.20794309
18Neurofibrillary tangles (HP:0002185)3.03269010
19Atrophic scars (HP:0001075)2.93662153
20Recurrent bacterial skin infections (HP:0005406)2.92484501
21Autoimmune thrombocytopenia (HP:0001973)2.84982903
22Cervical subluxation (HP:0003308)2.79885969
23Aplasia of the musculature (HP:0100854)2.76783584
24Disinhibition (HP:0000734)2.74008350
25Popliteal pterygium (HP:0009756)2.66780084
26Ulnar deviation of the wrist (HP:0003049)2.64405919
27Osteolytic defects of the phalanges of the hand (HP:0009771)2.64063253
28Osteolytic defects of the hand bones (HP:0009699)2.64063253
29Round ear (HP:0100830)2.63148367
30Elevated erythrocyte sedimentation rate (HP:0003565)2.63139404
31Increased cerebral lipofuscin (HP:0011813)2.62331615
32Increased connective tissue (HP:0009025)2.61276003
33Orchitis (HP:0100796)2.60849774
34Distal arthrogryposis (HP:0005684)2.56684811
35Spondylolisthesis (HP:0003302)2.54034338
36Thin bony cortex (HP:0002753)2.50135484
37Thick nail (HP:0001805)2.49637644
38Vacuolated lymphocytes (HP:0001922)2.49460222
39Myocardial infarction (HP:0001658)2.47528870
40Myositis (HP:0100614)2.47284825
41Abnormality of macrophages (HP:0004311)2.46727849
42Type 1 muscle fiber predominance (HP:0003803)2.45033033
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.44139994
44Cerebral aneurysm (HP:0004944)2.43607520
45Distal lower limb muscle weakness (HP:0009053)2.39786102
46Aortic dissection (HP:0002647)2.38762247
47Achilles tendon contracture (HP:0001771)2.38274261
48Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.37429082
49Trismus (HP:0000211)2.36488610
50Fragile skin (HP:0001030)2.36032601
51Apathy (HP:0000741)2.35874050
52Cerebral inclusion bodies (HP:0100314)2.35578821
53Right ventricular cardiomyopathy (HP:0011663)2.34097122
54Tetraparesis (HP:0002273)2.33710907
55Mutism (HP:0002300)2.33320583
56Prolonged neonatal jaundice (HP:0006579)2.32417153
57Distal lower limb amyotrophy (HP:0008944)2.32142215
58Spinal rigidity (HP:0003306)2.31576938
59Dilatation of the ascending aorta (HP:0005111)2.30740783
60Cupped ribs (HP:0000887)2.30225302
61Purpura (HP:0000979)2.30096977
62Pterygium (HP:0001059)2.29406535
63Malignant hyperthermia (HP:0002047)2.27751322
64Follicular hyperkeratosis (HP:0007502)2.27733666
65Difficulty climbing stairs (HP:0003551)2.26629254
66Interstitial pulmonary disease (HP:0006530)2.26159268
67Shallow orbits (HP:0000586)2.23965670
68Diminished motivation (HP:0000745)2.23603461
69Upper limb amyotrophy (HP:0009129)2.21480097
70Distal upper limb amyotrophy (HP:0007149)2.21480097
71Glomerulonephritis (HP:0000099)2.21005814
72Abnormality of the Achilles tendon (HP:0005109)2.19043037
73Asymmetric septal hypertrophy (HP:0001670)2.18727861
74Nemaline bodies (HP:0003798)2.16379652
75Progressive neurologic deterioration (HP:0002344)2.15754104
76Mediastinal lymphadenopathy (HP:0100721)2.15459387
77Muscle fiber inclusion bodies (HP:0100299)2.15443243
78Aortic aneurysm (HP:0004942)2.15302320
79Recurrent gram-negative bacterial infections (HP:0005420)2.14852311
80Axonal loss (HP:0003447)2.14404832
81Pustule (HP:0200039)2.11518264
82Short nail (HP:0001799)2.08342875
83Abnormality of placental membranes (HP:0011409)2.08320679
84Amniotic constriction ring (HP:0009775)2.08320679
85Breech presentation (HP:0001623)2.08082172
86Increased density of long bones (HP:0006392)2.07843420
87Abnormality of the distal phalanges of the toes (HP:0010182)2.06334316
88Soft skin (HP:0000977)2.05679668
89Vascular tortuosity (HP:0004948)2.03480654
90Abnormality of the vasculature of the conjunctiva (HP:0008054)2.03328896
91Calcaneovalgus deformity (HP:0001848)2.03037358
92Wormian bones (HP:0002645)2.02720404
93Upper motor neuron abnormality (HP:0002127)2.01308258
94Mitral stenosis (HP:0001718)2.01280681
95Blue sclerae (HP:0000592)2.01201118
96Absent phalangeal crease (HP:0006109)2.00687845
97Coxa vara (HP:0002812)1.99698905
98Increased IgM level (HP:0003496)1.98946600
99Bladder diverticulum (HP:0000015)1.98835789
100Fused cervical vertebrae (HP:0002949)1.98568084
101Hematochezia (HP:0002573)1.97880355
102Mildly elevated creatine phosphokinase (HP:0008180)1.97289617
103Genu recurvatum (HP:0002816)1.97179242
104Neuronal loss in central nervous system (HP:0002529)1.96338914
105Myopathic facies (HP:0002058)1.95622288
106Amyloidosis (HP:0011034)1.95528793
107Emphysema (HP:0002097)1.95465915
108Bone pain (HP:0002653)1.93715606
109Entropion (HP:0000621)1.91255583
110Long toe (HP:0010511)1.90829488
111Hip contracture (HP:0003273)1.89810891
112Hydroxyprolinuria (HP:0003080)1.89342274
113Abnormality of proline metabolism (HP:0010907)1.89342274
114Abnormality of the pericardium (HP:0001697)1.88577314
115Alopecia of scalp (HP:0002293)1.88543489
116Thin ribs (HP:0000883)1.88033695
117Malnutrition (HP:0004395)1.87311912
118Ovoid vertebral bodies (HP:0003300)1.86960705
119Retrobulbar optic neuritis (HP:0100654)1.86076883
120Optic neuritis (HP:0100653)1.86076883
121Cellulitis (HP:0100658)1.85565624
122Dysostosis multiplex (HP:0000943)1.85024029
123Gingivitis (HP:0000230)1.84000177
124Abnormal delivery (HP:0001787)1.82555738
125Arterial tortuosity (HP:0005116)1.82116307
126Metaphyseal irregularity (HP:0003025)1.82058657
127Biconcave vertebral bodies (HP:0004586)1.82028000
128Abnormality of the acetabulum (HP:0003170)1.81631959
129Hypergammaglobulinemia (HP:0010702)1.81418548
130Abnormality of the neuromuscular junction (HP:0003398)1.81263407
131Fatigable weakness (HP:0003473)1.81263407
132Deformed tarsal bones (HP:0008119)1.80384072
133Joint stiffness (HP:0001387)1.80177215
134Abnormality of complement system (HP:0005339)1.79833750
135Hand muscle atrophy (HP:0009130)1.79437259
136Petechiae (HP:0000967)1.79417387
137Abnormality of the calcaneus (HP:0008364)1.79277792
138Increased serum ferritin (HP:0003281)1.78518843
139Flat acetabular roof (HP:0003180)1.78485786
140Recurrent fungal infections (HP:0002841)1.78304942
141Muscle fiber splitting (HP:0003555)1.78302350
142Natal tooth (HP:0000695)1.78301041
143J-shaped sella turcica (HP:0002680)1.78082257
144Ankle contracture (HP:0006466)1.78075330
145Complement deficiency (HP:0004431)1.77201466
146Parakeratosis (HP:0001036)1.76829189
147Mitral regurgitation (HP:0001653)1.76568317
148Porencephaly (HP:0002132)1.76507678
149Increased IgE level (HP:0003212)1.76027288
150Aneurysm (HP:0002617)1.75918193
151Basal ganglia calcification (HP:0002135)1.75634727
152Protuberant abdomen (HP:0001538)1.73863934
153Femoral bowing (HP:0002980)1.73551354
154Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.69345812
155Hepatosplenomegaly (HP:0001433)1.66883903
156Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.66566889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.08924233
2TBK13.04308522
3ERN12.96072689
4MAP3K142.93178785
5GRK72.74368034
6DDR22.58126482
7TESK12.55105982
8PRPF4B2.40705742
9IKBKB2.16827325
10PBK2.15793847
11EPHA22.06670609
12BMX2.05523834
13MOS1.98820824
14MAP3K31.96521095
15TYK21.95061215
16BLK1.91728499
17IRAK31.86814954
18CHUK1.85463588
19NME21.84842655
20EPHB11.84621560
21IKBKE1.72614948
22NEK91.71965949
23CDC42BPA1.65831274
24RIPK11.61433768
25LIMK11.56923614
26EPHA31.53852105
27LRRK21.51839596
28MYLK1.50654500
29MAP3K111.49340348
30RPS6KA41.48520799
31TESK21.48508738
32JAK31.46356682
33PAK41.39397084
34STK101.38991295
35TRPM71.37096064
36PIK3CG1.30068315
37JAK11.29717112
38IRAK41.27998325
39MST41.27191278
40TTN1.26035228
41PKN21.24019127
42CSK1.22149055
43ABL21.19651312
44MAPKAPK31.18726401
45RIPK41.18405365
46PTK61.16819054
47FER1.16204302
48PDGFRA1.11270356
49EPHB21.07914095
50ICK1.07732141
51TAOK11.04982639
52PTK21.03259683
53SIK31.02814360
54TGFBR21.00327547
55KIT1.00318286
56MATK0.94931286
57PRKD20.94718081
58MAP3K10.93792151
59DMPK0.93567241
60MST1R0.91505218
61MAPKAPK20.91380701
62PAK20.90384812
63FGFR30.89461296
64STK30.89051997
65LATS20.88024954
66FGFR40.83745702
67BMPR20.83557224
68TAOK20.83484742
69* PIM10.82477171
70HCK0.80139354
71MAP4K10.78547839
72LATS10.78289609
73MAP2K10.77820419
74NTRK10.77418830
75SMG10.76486035
76MAP2K30.76180961
77AKT30.72327253
78ADRBK20.71919575
79ZAP700.71808289
80PRKG20.70849112
81MAP2K20.69841403
82CDK120.69401486
83RPS6KA20.69346185
84MAP3K130.68617737
85ILK0.67887206
86KDR0.67707294
87EGFR0.66530257
88CSF1R0.66086135
89FGR0.59887230
90* ABL10.59212930
91MAP3K100.57368412
92MAP3K80.56825175
93ERBB40.56483501
94EIF2AK20.55211120
95PTK2B0.55143846
96RPS6KL10.54937387
97RPS6KC10.54937387
98IRAK20.52614651
99CLK10.50797372
100PDGFRB0.50564858
101STK40.49844478
102HIPK20.49720412
103* PIM20.49534641
104JAK20.49378992
105CDK90.48805199
106LCK0.48768336
107LMTK20.47475975
108PDPK10.47246367
109ALK0.46605596
110TAOK30.46185145
111TYRO30.46130355
112SIK10.45916512
113EEF2K0.45180915
114* DAPK30.44993489
115MAPK70.44888302
116PAK10.44694297
117GSK3A0.44537327
118ROCK20.43957099
119MET0.43797142
120STK240.43483414
121CAMK2G0.42599208
122ARAF0.41306675
123IRAK10.40625861
124MTOR0.40341400
125MARK30.39743067
126ERBB30.39339235
127TGFBR10.38863521
128ROCK10.37480201
129PRKCD0.37326525
130INSR0.36707616
131RPS6KA60.36001695
132DYRK30.29964588
133MARK20.29313074
134* MAP3K50.29172752
135STK380.28694011

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.61638177
2Malaria_Homo sapiens_hsa051442.23715899
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.18776468
4Allograft rejection_Homo sapiens_hsa053301.99769656
5Legionellosis_Homo sapiens_hsa051341.97114147
6Graft-versus-host disease_Homo sapiens_hsa053321.96908172
7TNF signaling pathway_Homo sapiens_hsa046681.96677112
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.93336136
9Shigellosis_Homo sapiens_hsa051311.90700885
10Osteoclast differentiation_Homo sapiens_hsa043801.89152612
11Pertussis_Homo sapiens_hsa051331.83716127
12Toxoplasmosis_Homo sapiens_hsa051451.81511367
13Apoptosis_Homo sapiens_hsa042101.77387214
14Viral myocarditis_Homo sapiens_hsa054161.74167234
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.72958789
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.68552273
17Salmonella infection_Homo sapiens_hsa051321.68101982
18Measles_Homo sapiens_hsa051621.67782833
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66593194
20Tuberculosis_Homo sapiens_hsa051521.66547507
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64892148
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.62887484
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62702939
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61492862
25Rheumatoid arthritis_Homo sapiens_hsa053231.59229836
26* p53 signaling pathway_Homo sapiens_hsa041151.57248566
27ECM-receptor interaction_Homo sapiens_hsa045121.54538088
28Influenza A_Homo sapiens_hsa051641.49676758
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.46845576
30Phagosome_Homo sapiens_hsa041451.46557749
31Lysosome_Homo sapiens_hsa041421.45596283
32Amoebiasis_Homo sapiens_hsa051461.44767508
33Small cell lung cancer_Homo sapiens_hsa052221.38200307
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36458595
35* Proteoglycans in cancer_Homo sapiens_hsa052051.33116824
36Focal adhesion_Homo sapiens_hsa045101.32905069
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31440550
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.28565173
39Adherens junction_Homo sapiens_hsa045201.27914753
40* Jak-STAT signaling pathway_Homo sapiens_hsa046301.25271865
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23688203
42* Chronic myeloid leukemia_Homo sapiens_hsa052201.21175661
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19733426
44Staphylococcus aureus infection_Homo sapiens_hsa051501.19553763
45Asthma_Homo sapiens_hsa053101.18361159
46* Hepatitis B_Homo sapiens_hsa051611.17451684
47Vibrio cholerae infection_Homo sapiens_hsa051101.16429425
48Herpes simplex infection_Homo sapiens_hsa051681.15480162
49* Bladder cancer_Homo sapiens_hsa052191.09566805
50B cell receptor signaling pathway_Homo sapiens_hsa046621.05760428
51Acute myeloid leukemia_Homo sapiens_hsa052211.05141370
52* MicroRNAs in cancer_Homo sapiens_hsa052061.02896076
53Pancreatic cancer_Homo sapiens_hsa052121.02092045
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.00063056
55Hematopoietic cell lineage_Homo sapiens_hsa046400.99544003
56Complement and coagulation cascades_Homo sapiens_hsa046100.98702983
57Chemokine signaling pathway_Homo sapiens_hsa040620.98556421
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98037761
59* Hepatitis C_Homo sapiens_hsa051600.96184655
60Antigen processing and presentation_Homo sapiens_hsa046120.95691058
61Sulfur metabolism_Homo sapiens_hsa009200.93648078
62African trypanosomiasis_Homo sapiens_hsa051430.92814843
63Autoimmune thyroid disease_Homo sapiens_hsa053200.91796277
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90651047
65Type I diabetes mellitus_Homo sapiens_hsa049400.90559485
66Prolactin signaling pathway_Homo sapiens_hsa049170.89619117
67Galactose metabolism_Homo sapiens_hsa000520.88715073
68Other glycan degradation_Homo sapiens_hsa005110.87173174
69TGF-beta signaling pathway_Homo sapiens_hsa043500.85894923
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85768305
71* HIF-1 signaling pathway_Homo sapiens_hsa040660.84275752
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82212645
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80994468
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76687882
75VEGF signaling pathway_Homo sapiens_hsa043700.76265726
76Platelet activation_Homo sapiens_hsa046110.75840724
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.74995774
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74647392
79* HTLV-I infection_Homo sapiens_hsa051660.74003600
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73114036
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71161534
82* Viral carcinogenesis_Homo sapiens_hsa052030.69835376
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69789880
84Hippo signaling pathway_Homo sapiens_hsa043900.68913830
85Dilated cardiomyopathy_Homo sapiens_hsa054140.68295969
86Renin-angiotensin system_Homo sapiens_hsa046140.67192917
87PPAR signaling pathway_Homo sapiens_hsa033200.66038740
88Mineral absorption_Homo sapiens_hsa049780.65764374
89* Epstein-Barr virus infection_Homo sapiens_hsa051690.64434894
90Endocytosis_Homo sapiens_hsa041440.62591495
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60702566
92* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59780014
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.59236529
94Tight junction_Homo sapiens_hsa045300.58423168
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.57481230
96Protein digestion and absorption_Homo sapiens_hsa049740.57444475
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56093626
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55264829
99Renal cell carcinoma_Homo sapiens_hsa052110.54895014
100Collecting duct acid secretion_Homo sapiens_hsa049660.54663113
101* Pathways in cancer_Homo sapiens_hsa052000.53091529
102Fructose and mannose metabolism_Homo sapiens_hsa000510.52590048
103* Prostate cancer_Homo sapiens_hsa052150.51941077
104* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50823822
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48788342
106Notch signaling pathway_Homo sapiens_hsa043300.47528844
107T cell receptor signaling pathway_Homo sapiens_hsa046600.47063185
108Prion diseases_Homo sapiens_hsa050200.45967906
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45268658
110* Melanoma_Homo sapiens_hsa052180.44801733
111Insulin resistance_Homo sapiens_hsa049310.44594728
112Sphingolipid metabolism_Homo sapiens_hsa006000.43117515
113Type II diabetes mellitus_Homo sapiens_hsa049300.42490424
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42407483
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.36332839
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.33471135
117Steroid biosynthesis_Homo sapiens_hsa001000.33256837

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