CDKN2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.96576819
2ribosomal small subunit biogenesis (GO:0042274)5.64602440
3chondrocyte proliferation (GO:0035988)5.36466128
4regulation of translational termination (GO:0006449)5.11141154
5cell adhesion mediated by integrin (GO:0033627)4.97948555
6collagen fibril organization (GO:0030199)4.91220740
7endodermal cell differentiation (GO:0035987)4.88203326
8skin morphogenesis (GO:0043589)4.74633961
9cellular response to vitamin (GO:0071295)4.73907763
10negative regulation of fatty acid transport (GO:2000192)4.62298540
11deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.39005268
12lymph vessel development (GO:0001945)4.38123027
13positive regulation of endothelial cell apoptotic process (GO:2000353)4.24304462
14folic acid metabolic process (GO:0046655)4.17071514
15regulation of mammary gland epithelial cell proliferation (GO:0033599)4.12124541
16nucleobase-containing small molecule interconversion (GO:0015949)4.05343963
17cellular response to vitamin D (GO:0071305)3.96746282
18DNA unwinding involved in DNA replication (GO:0006268)3.94374784
19regulation of apoptotic process involved in morphogenesis (GO:1902337)3.92895903
20embryonic skeletal joint morphogenesis (GO:0060272)3.92123714
21peptidyl-proline hydroxylation (GO:0019511)3.91503570
22bone trabecula formation (GO:0060346)3.89874319
23protein maturation by protein folding (GO:0022417)3.87495846
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.87367065
25maturation of SSU-rRNA (GO:0030490)3.87095060
26neuron projection extension involved in neuron projection guidance (GO:1902284)3.86950980
27axon extension involved in axon guidance (GO:0048846)3.86950980
28plasma membrane repair (GO:0001778)3.83262813
29regulation of mitochondrial translation (GO:0070129)3.77474335
30mitotic chromosome condensation (GO:0007076)3.74307020
31polarized epithelial cell differentiation (GO:0030859)3.73764018
32DNA strand elongation involved in DNA replication (GO:0006271)3.71697837
33DNA replication checkpoint (GO:0000076)3.66933889
34ribonucleoprotein complex biogenesis (GO:0022613)3.66687351
35DNA strand elongation (GO:0022616)3.65045888
36mitotic sister chromatid segregation (GO:0000070)3.63594205
37mitotic nuclear envelope reassembly (GO:0007084)3.60499397
38nuclear envelope reassembly (GO:0031468)3.60499397
39positive regulation of hair cycle (GO:0042635)3.56217452
40positive regulation of hair follicle development (GO:0051798)3.56217452
41outer ear morphogenesis (GO:0042473)3.54605093
42DNA replication initiation (GO:0006270)3.53967915
43regulation of hippo signaling (GO:0035330)3.51601872
44regulation of translational fidelity (GO:0006450)3.49981095
45collagen metabolic process (GO:0032963)3.44912520
46mesenchymal-epithelial cell signaling (GO:0060638)3.44539684
47hippo signaling (GO:0035329)3.44122900
48epithelial cell-cell adhesion (GO:0090136)3.44118788
49protein hydroxylation (GO:0018126)3.43311263
50ribosome biogenesis (GO:0042254)3.42837492
51telomere maintenance via semi-conservative replication (GO:0032201)3.41448897
52basement membrane organization (GO:0071711)3.39151228
53apoptotic cell clearance (GO:0043277)3.38856117
54collagen catabolic process (GO:0030574)3.38573041
55viral mRNA export from host cell nucleus (GO:0046784)3.36052477
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.35964230
57cellular response to nutrient (GO:0031670)3.34965900
58pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.33371445
59establishment of apical/basal cell polarity (GO:0035089)3.31714932
60proline biosynthetic process (GO:0006561)3.30348344
61regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.27042268
62negative regulation of adherens junction organization (GO:1903392)3.26644212
63negative regulation of focal adhesion assembly (GO:0051895)3.26644212
64negative regulation of cell junction assembly (GO:1901889)3.26644212
65adherens junction assembly (GO:0034333)3.23801147
66formation of translation preinitiation complex (GO:0001731)3.23391861
67multicellular organismal macromolecule metabolic process (GO:0044259)3.22638824
68pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.21719808
69peptidyl-arginine omega-N-methylation (GO:0035247)3.20820824
70pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.20155023
71extracellular matrix disassembly (GO:0022617)3.19407928
72regulation of glucocorticoid metabolic process (GO:0031943)3.19008310
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17558577
74paraxial mesoderm development (GO:0048339)3.16016444
75craniofacial suture morphogenesis (GO:0097094)3.14574465
76protein retention in ER lumen (GO:0006621)3.13696573
77pseudouridine synthesis (GO:0001522)3.12564660
78multicellular organismal catabolic process (GO:0044243)3.12257206
79GDP-mannose metabolic process (GO:0019673)3.11690918
80thyroid gland development (GO:0030878)3.10600573
81UTP biosynthetic process (GO:0006228)3.09290927
82negative regulation of chondrocyte differentiation (GO:0032331)3.08442952
83protein localization to chromosome, centromeric region (GO:0071459)3.07420853
84ncRNA 3-end processing (GO:0043628)3.07309010
85negative regulation of cell size (GO:0045792)3.06903813
86diaphragm development (GO:0060539)3.06707511
87sister chromatid segregation (GO:0000819)3.05539331
88guanosine-containing compound biosynthetic process (GO:1901070)3.05284363
89regulation of protein heterodimerization activity (GO:0043497)3.05104405
90planar cell polarity pathway involved in neural tube closure (GO:0090179)3.04101481
91response to UV-C (GO:0010225)3.04032002
92multicellular organismal metabolic process (GO:0044236)3.03323623
93protein complex localization (GO:0031503)3.03004881
94cellular protein complex localization (GO:0034629)3.02053515
95rRNA transcription (GO:0009303)3.00963694
96viral transcription (GO:0019083)3.00851216
97* heterochromatin organization (GO:0070828)3.00406509
98tRNA methylation (GO:0030488)3.00075970
99protein localization to cell surface (GO:0034394)2.98737866
100cell-substrate junction assembly (GO:0007044)2.97939311
101regulation of SMAD protein import into nucleus (GO:0060390)2.97511644
102spliceosomal tri-snRNP complex assembly (GO:0000244)2.96596143
103pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.94902971
104folic acid-containing compound biosynthetic process (GO:0009396)2.91850754
105cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.91640614
106regulation of tight junction assembly (GO:2000810)2.91192296
107cell migration involved in sprouting angiogenesis (GO:0002042)2.89920974
108negative regulation of smooth muscle cell migration (GO:0014912)2.89793898
109regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88388466
110maternal placenta development (GO:0001893)2.88334371
111germ cell migration (GO:0008354)2.88130005
112translational elongation (GO:0006414)2.86275901
113CTP biosynthetic process (GO:0006241)2.86149484
114CTP metabolic process (GO:0046036)2.86149484
115apoptotic process involved in morphogenesis (GO:0060561)2.86050499
116COPI coating of Golgi vesicle (GO:0048205)2.84305945
117Golgi transport vesicle coating (GO:0048200)2.84305945
118cellular response to interferon-alpha (GO:0035457)2.84075337
119regulation of integrin activation (GO:0033623)2.83874848
120stress fiber assembly (GO:0043149)2.83268208
121positive regulation of DNA-dependent DNA replication (GO:2000105)2.83056990
122translational termination (GO:0006415)2.82224969
123regulation of translational elongation (GO:0006448)2.81650896
124kidney mesenchyme development (GO:0072074)2.80365913
125embryonic heart tube development (GO:0035050)2.79869975
126labyrinthine layer blood vessel development (GO:0060716)2.79165194
127* rRNA processing (GO:0006364)2.79134697
128positive regulation of blood vessel endothelial cell migration (GO:0043536)2.78339258
129negative regulation of mRNA processing (GO:0050686)2.77367404
130ribosomal large subunit biogenesis (GO:0042273)2.77222032
131mRNA transcription (GO:0009299)2.76570565
132wound healing, spreading of epidermal cells (GO:0035313)2.76220765
133cellular component biogenesis (GO:0044085)2.75923501
134UTP metabolic process (GO:0046051)2.75796292
135cochlea morphogenesis (GO:0090103)2.75322923
136sequestering of extracellular ligand from receptor (GO:0035581)2.74714794
137cytoskeletal anchoring at plasma membrane (GO:0007016)2.73841106
138substrate adhesion-dependent cell spreading (GO:0034446)2.73554843
139embryonic camera-type eye development (GO:0031076)2.72439179
140negative regulation of DNA repair (GO:0045738)2.71022117
141oxidative phosphorylation (GO:0006119)2.70973538
142endocardial cushion development (GO:0003197)2.70755722
143nucleoside salvage (GO:0043174)2.70712949
144mammary gland epithelial cell differentiation (GO:0060644)2.69971827
145negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.69833731
146positive regulation of SMAD protein import into nucleus (GO:0060391)2.69260907
147establishment of monopolar cell polarity (GO:0061162)2.68355873
148establishment or maintenance of monopolar cell polarity (GO:0061339)2.68355873
149positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.67562982
150mesodermal cell differentiation (GO:0048333)2.67230101
151nucleobase biosynthetic process (GO:0046112)2.67103865
152response to laminar fluid shear stress (GO:0034616)2.66490119
153axis elongation (GO:0003401)2.65954555
154ventricular cardiac muscle cell development (GO:0055015)2.65774121
155protein localization to endosome (GO:0036010)2.64253911
156positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.63928896
157protein targeting to mitochondrion (GO:0006626)2.63896617
158activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.63764916
159* rRNA metabolic process (GO:0016072)2.63440160
160cellular response to amino acid stimulus (GO:0071230)2.62615963
161regulation of mitotic spindle organization (GO:0060236)2.62595551
1624-hydroxyproline metabolic process (GO:0019471)2.62167051
163histone arginine methylation (GO:0034969)2.62139296
164telomere maintenance via recombination (GO:0000722)2.62057021
165mitotic cytokinesis (GO:0000281)2.61973496
166cell-substrate adherens junction assembly (GO:0007045)2.61263619
167focal adhesion assembly (GO:0048041)2.61263619
168muscle cell fate commitment (GO:0042693)2.61168692
169embryonic cranial skeleton morphogenesis (GO:0048701)2.60848500
170GTP biosynthetic process (GO:0006183)2.60211072
171pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.60181197
172protein localization to kinetochore (GO:0034501)2.59170279
173folic acid-containing compound metabolic process (GO:0006760)2.59026625
174chromosome condensation (GO:0030261)2.58699001
175ribosome assembly (GO:0042255)2.58393748
176transcription from mitochondrial promoter (GO:0006390)2.58355110
177osteoblast differentiation (GO:0001649)2.58232958
178response to fluid shear stress (GO:0034405)2.57747527
179maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57500489
180SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.57412013
181positive regulation of nuclease activity (GO:0032075)2.57246287
182blood vessel endothelial cell migration (GO:0043534)2.57233635
183nuclear pore complex assembly (GO:0051292)2.57089598
184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.56856661
185metanephric mesenchyme development (GO:0072075)2.56839839
186negative regulation of RNA splicing (GO:0033119)2.56258910
187purine nucleobase biosynthetic process (GO:0009113)2.56149104
188positive regulation of epithelial to mesenchymal transition (GO:0010718)2.55587410
189proteasome assembly (GO:0043248)2.55570695
190proximal/distal pattern formation (GO:0009954)2.54404303
191negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.53985834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.01066666
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.52516858
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.01652501
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.53871553
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.35869079
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.18407722
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.08640784
8CLOCK_20551151_ChIP-Seq_293T_Human2.78361268
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70849683
10RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.69444898
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53011058
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49366805
13E2F7_22180533_ChIP-Seq_HELA_Human2.41156180
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.22758347
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.21288448
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20902552
17ESR1_15608294_ChIP-ChIP_MCF-7_Human2.10011560
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.08893496
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06860816
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.04825287
21* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.04000902
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99015586
23DCP1A_22483619_ChIP-Seq_HELA_Human1.98965958
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.98555830
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97807829
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.96488725
27ATF3_27146783_Chip-Seq_COLON_Human1.91527235
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90253962
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.86350407
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84906735
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82995973
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.81431748
33P300_27058665_Chip-Seq_ZR-75-30cells_Human1.78622681
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77687528
35TTF2_22483619_ChIP-Seq_HELA_Human1.73778378
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68852657
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68767835
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.67876001
39MYC_22102868_ChIP-Seq_BL_Human1.67702262
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67175089
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.66665292
42GABP_19822575_ChIP-Seq_HepG2_Human1.64325319
43AR_21909140_ChIP-Seq_LNCAP_Human1.63684155
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63083902
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62826903
46RACK7_27058665_Chip-Seq_MCF-7_Human1.62789403
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.62743821
48* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61818301
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60275531
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.60063237
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56296106
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.55170668
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55141466
54CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.54848191
55BRD4_25478319_ChIP-Seq_HGPS_Human1.54396924
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54055114
57TFEB_21752829_ChIP-Seq_HELA_Human1.51030038
58ZNF263_19887448_ChIP-Seq_K562_Human1.49011739
59* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.48081290
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47936242
61TP53_22127205_ChIP-Seq_IMR90_Human1.47521632
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46725082
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46289117
64KDM5A_27292631_Chip-Seq_BREAST_Human1.46019380
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45723891
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45600351
67VDR_21846776_ChIP-Seq_THP-1_Human1.44436240
68TCF3_18692474_ChIP-Seq_MEFs_Mouse1.43449150
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41472837
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41242848
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41242848
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.40982437
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40084810
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39764752
75KDM2B_26808549_Chip-Seq_DND41_Human1.37065133
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35816133
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35497989
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35403145
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32957199
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32514996
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31943873
82UBF1/2_26484160_Chip-Seq_HMECs_Human1.31810056
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31784643
84* P68_20966046_ChIP-Seq_HELA_Human1.30291220
85LXR_22292898_ChIP-Seq_THP-1_Human1.30040703
86SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29979531
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29797559
88* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28721871
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28058622
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27730510
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27683611
92* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26588374
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25748261
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24923240
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24091306
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24018450
97CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23989192
98PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22849596
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.22396292
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21858080
101ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20502337
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18715732
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18697102
104YY1_21170310_ChIP-Seq_MESCs_Mouse1.18195091
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17434613
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17173809
107NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16562715
108FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.15546448
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15121530
110TP53_23651856_ChIP-Seq_MEFs_Mouse1.14818985
111CIITA_25753668_ChIP-Seq_RAJI_Human1.14081121
112CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12869770
113TCF7_22412390_ChIP-Seq_EML_Mouse1.11611601
114CJUN_26792858_Chip-Seq_BT549_Human1.11578470
115EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11397864
116CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10550914
117ELF1_20517297_ChIP-Seq_JURKAT_Human1.10374617
118SA1_27219007_Chip-Seq_ERYTHROID_Human1.10226891
119EST1_17652178_ChIP-ChIP_JURKAT_Human1.10194053
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09590929
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09157610
122JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08871151
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08577561
124KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08357984
125KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08357984
126KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08357984
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07357117
128* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07146084
129ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06732305
130NCOR1_26117541_ChIP-Seq_K562_Human1.06510561
131FOXO3_23340844_ChIP-Seq_DLD1_Human1.04845350
132SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04678188
133FOXP1_21924763_ChIP-Seq_HESCs_Human1.04505948
134TP63_19390658_ChIP-ChIP_HaCaT_Human1.04460893
135PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04398058
136MAF_26560356_Chip-Seq_TH2_Human1.04127696
137SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04057311
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03212056
139THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03192933
140PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02681363
141FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01966379
142* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01396608
143NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01114087
144RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99867253
145CHD1_26751641_Chip-Seq_LNCaP_Human0.99816341
146SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99637269
147KDM2B_26808549_Chip-Seq_JURKAT_Human0.99630182
148* TP53_20018659_ChIP-ChIP_R1E_Mouse0.98420452
149CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97321702
150YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96822611
151ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95967923
152FOXP3_21729870_ChIP-Seq_TREG_Human0.95249429
153XRN2_22483619_ChIP-Seq_HELA_Human0.94226170
154E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93755391
155SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93705515
156E2F1_21310950_ChIP-Seq_MCF-7_Human0.92894868
157EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92401945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.56412990
2MP0003705_abnormal_hypodermis_morpholog4.85074506
3MP0010352_gastrointestinal_tract_polyps3.64862687
4MP0005275_abnormal_skin_tensile3.63361913
5MP0005503_abnormal_tendon_morphology3.57413776
6MP0003693_abnormal_embryo_hatching3.28542271
7MP0001346_abnormal_lacrimal_gland3.26769076
8* MP0003111_abnormal_nucleus_morphology3.14246886
9MP0000678_abnormal_parathyroid_gland2.92984810
10MP0002249_abnormal_larynx_morphology2.80537531
11MP0002163_abnormal_gland_morphology2.64463753
12MP0002234_abnormal_pharynx_morphology2.64387887
13MP0010094_abnormal_chromosome_stability2.61839600
14MP0008932_abnormal_embryonic_tissue2.61524665
15* MP0003077_abnormal_cell_cycle2.56553136
16MP0004272_abnormal_basement_membrane2.55592289
17MP0003279_aneurysm2.54642459
18MP0003566_abnormal_cell_adhesion2.41559472
19* MP0005623_abnormal_meninges_morphology2.27922471
20MP0005023_abnormal_wound_healing2.15999120
21MP0003091_abnormal_cell_migration2.11013097
22MP0003283_abnormal_digestive_organ2.08669132
23MP0010030_abnormal_orbit_morphology2.06482631
24MP0001958_emphysema2.00570867
25MP0005257_abnormal_intraocular_pressure1.98682410
26* MP0000733_abnormal_muscle_development1.98412882
27MP0005076_abnormal_cell_differentiation1.97423680
28MP0006054_spinal_hemorrhage1.96263230
29MP0000681_abnormal_thyroid_gland1.95373330
30MP0002060_abnormal_skin_morphology1.93498709
31MP0005508_abnormal_skeleton_morphology1.85430671
32MP0001661_extended_life_span1.84868281
33MP0009384_cardiac_valve_regurgitation1.82955167
34MP0000049_abnormal_middle_ear1.80389777
35MP0001348_abnormal_lacrimal_gland1.74304063
36MP0004185_abnormal_adipocyte_glucose1.64766792
37MP0008058_abnormal_DNA_repair1.62719967
38MP0005451_abnormal_body_composition1.61558178
39* MP0010307_abnormal_tumor_latency1.57362980
40MP0002896_abnormal_bone_mineralization1.57060809
41MP0001542_abnormal_bone_strength1.52096207
42MP0001849_ear_inflammation1.51755823
43MP0000537_abnormal_urethra_morphology1.50954090
44MP0003315_abnormal_perineum_morphology1.50163585
45MP0000428_abnormal_craniofacial_morphol1.48905302
46MP0003385_abnormal_body_wall1.48773947
47MP0009278_abnormal_bone_marrow1.44886693
48MP0009053_abnormal_anal_canal1.43500903
49MP0000762_abnormal_tongue_morphology1.43082898
50* MP0005501_abnormal_skin_physiology1.40949977
51MP0002160_abnormal_reproductive_system1.39790183
52MP0003300_gastrointestinal_ulcer1.36453922
53MP0004197_abnormal_fetal_growth/weight/1.32234240
54MP0003806_abnormal_nucleotide_metabolis1.31587885
55MP0003115_abnormal_respiratory_system1.31348524
56MP0001299_abnormal_eye_distance/1.29541428
57* MP0008007_abnormal_cellular_replicative1.28763242
58MP0003942_abnormal_urinary_system1.28136786
59MP0001243_abnormal_dermal_layer1.26943528
60MP0005670_abnormal_white_adipose1.24544321
61MP0000534_abnormal_ureter_morphology1.24249058
62MP0010234_abnormal_vibrissa_follicle1.22287610
63MP0009250_abnormal_appendicular_skeleto1.21533135
64MP0005379_endocrine/exocrine_gland_phen1.19607332
65MP0000579_abnormal_nail_morphology1.17859156
66* MP0002877_abnormal_melanocyte_morpholog1.17493839
67MP0002089_abnormal_postnatal_growth/wei1.16695904
68MP0000750_abnormal_muscle_regeneration1.16143094
69* MP0000313_abnormal_cell_death1.15110611
70MP0002932_abnormal_joint_morphology1.13141444
71* MP0003786_premature_aging1.10178311
72MP0002108_abnormal_muscle_morphology1.08790478
73MP0002111_abnormal_tail_morphology1.04603725
74MP0002295_abnormal_pulmonary_circulatio1.03044244
75MP0003755_abnormal_palate_morphology1.02612734
76MP0002115_abnormal_skeleton_extremities1.02394713
77MP0005390_skeleton_phenotype1.01946634
78MP0002282_abnormal_trachea_morphology0.99535950
79MP0001915_intracranial_hemorrhage0.99345017
80MP0002796_impaired_skin_barrier0.99183892
81MP0004808_abnormal_hematopoietic_stem0.98817266
82MP0000003_abnormal_adipose_tissue0.98222184
83MP0002113_abnormal_skeleton_development0.98213879
84MP0000163_abnormal_cartilage_morphology0.97436598
85MP0004233_abnormal_muscle_weight0.97402610
86* MP0009333_abnormal_splenocyte_physiolog0.96787936
87MP0000432_abnormal_head_morphology0.96666036
88* MP0000858_altered_metastatic_potential0.96480978
89MP0002084_abnormal_developmental_patter0.96090622
90* MP0000350_abnormal_cell_proliferation0.95105559
91MP0009379_abnormal_foot_pigmentation0.94982456
92* MP0002697_abnormal_eye_size0.94519593
93MP0003937_abnormal_limbs/digits/tail_de0.92596034
94* MP0003453_abnormal_keratinocyte_physiol0.91101115
95MP0005330_cardiomyopathy0.90435448
96MP0001919_abnormal_reproductive_system0.89589999
97MP0004957_abnormal_blastocyst_morpholog0.89207705
98MP0002177_abnormal_outer_ear0.88026493
99MP0004134_abnormal_chest_morphology0.87104839
100* MP0002114_abnormal_axial_skeleton0.87075204
101MP0000490_abnormal_crypts_of0.86863880
102MP0004858_abnormal_nervous_system0.86798450
103MP0000358_abnormal_cell_content/0.86199849
104* MP0002085_abnormal_embryonic_tissue0.85831354
105MP0002086_abnormal_extraembryonic_tissu0.85815437
106MP0000627_abnormal_mammary_gland0.84940631
107MP0001270_distended_abdomen0.84347433
108* MP0002019_abnormal_tumor_incidence0.84330326
109MP0005375_adipose_tissue_phenotype0.84329227
110MP0002098_abnormal_vibrissa_morphology0.83970379
111* MP0000759_abnormal_skeletal_muscle0.83763246
112MP0005666_abnormal_adipose_tissue0.83535226
113MP0003186_abnormal_redox_activity0.83155314
114MP0001881_abnormal_mammary_gland0.83122250
115* MP0003448_altered_tumor_morphology0.82901688
116MP0001879_abnormal_lymphatic_vessel0.82686917
117MP0002998_abnormal_bone_remodeling0.82417263
118MP0002925_abnormal_cardiovascular_devel0.82216350
119MP0000767_abnormal_smooth_muscle0.82170024
120MP0003984_embryonic_growth_retardation0.81203593
121MP0004782_abnormal_surfactant_physiolog0.81102978
122* MP0005621_abnormal_cell_physiology0.80907817
123MP0002088_abnormal_embryonic_growth/wei0.80657106
124* MP0003045_fibrosis0.80588703
125MP0003795_abnormal_bone_structure0.80408060
126MP0001614_abnormal_blood_vessel0.80023686
127MP0003935_abnormal_craniofacial_develop0.79182530
128MP0006036_abnormal_mitochondrial_physio0.78775703
129MP0005380_embryogenesis_phenotype0.78632795
130MP0001672_abnormal_embryogenesis/_devel0.78632795
131MP0001545_abnormal_hematopoietic_system0.78612281
132MP0005397_hematopoietic_system_phenotyp0.78612281
133MP0000013_abnormal_adipose_tissue0.78487530
134MP0005187_abnormal_penis_morphology0.78134585
135* MP0002092_abnormal_eye_morphology0.77759111
136MP0002933_joint_inflammation0.77405917
137MP0001697_abnormal_embryo_size0.77014006
138MP0002116_abnormal_craniofacial_bone0.76963856
139MP0005197_abnormal_uvea_morphology0.76841526
140* MP0001730_embryonic_growth_arrest0.76801529
141MP0005389_reproductive_system_phenotype0.76523294
142* MP0002168_other_aberrant_phenotype0.76140940
143MP0001873_stomach_inflammation0.75918235
144MP0000467_abnormal_esophagus_morphology0.75683966
145MP0002109_abnormal_limb_morphology0.73785023
146* MP0005193_abnormal_anterior_eye0.73470678
147MP0005058_abnormal_lysosome_morphology0.72122022
148* MP0002080_prenatal_lethality0.70881560
149MP0000516_abnormal_urinary_system0.70736123
150MP0005367_renal/urinary_system_phenotyp0.70736123

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.72860325
2Premature rupture of membranes (HP:0001788)7.07814504
3Ankle contracture (HP:0006466)5.22072566
4Shallow orbits (HP:0000586)4.91956201
5Cervical subluxation (HP:0003308)4.40830710
6Peritonitis (HP:0002586)4.28440752
7Atrophic scars (HP:0001075)4.12903899
8Broad distal phalanx of finger (HP:0009836)4.08147872
9Aplasia/Hypoplasia of the sacrum (HP:0008517)4.05867995
10Cerebral aneurysm (HP:0004944)3.80025298
11Abnormality of dentin (HP:0010299)3.77245522
12Genu recurvatum (HP:0002816)3.62767640
13Abnormal umbilical cord blood vessels (HP:0011403)3.59204966
14Single umbilical artery (HP:0001195)3.59204966
15Abnormality of the fetal cardiovascular system (HP:0010948)3.59204966
16Abnormality of the distal phalanges of the toes (HP:0010182)3.56879288
17Congenital malformation of the right heart (HP:0011723)3.53878962
18Double outlet right ventricle (HP:0001719)3.53878962
19Vertebral compression fractures (HP:0002953)3.43125335
20Aortic dissection (HP:0002647)3.41047342
21Soft skin (HP:0000977)3.39754960
22Fragile skin (HP:0001030)3.36865305
23Neonatal short-limb short stature (HP:0008921)3.33450195
24Wrist flexion contracture (HP:0001239)3.33382191
25Broad metatarsal (HP:0001783)3.26264224
26Abnormality of the umbilical cord (HP:0010881)3.26191935
27Bladder diverticulum (HP:0000015)3.24877973
28Unilateral renal agenesis (HP:0000122)3.24190562
29Ulnar bowing (HP:0003031)3.18969699
30Septate vagina (HP:0001153)3.16971402
31Dilatation of the ascending aorta (HP:0005111)3.12665007
32Blue sclerae (HP:0000592)3.09640105
33Microretrognathia (HP:0000308)3.03050535
34Trismus (HP:0000211)3.01940541
35Abnormality of the phalanges of the hallux (HP:0010057)3.01473106
36Wormian bones (HP:0002645)2.98362569
37Abnormal connection of the cardiac segments (HP:0011545)2.96156140
38Abnormal ventriculo-arterial connection (HP:0011563)2.96156140
39Transposition of the great arteries (HP:0001669)2.96156140
40Mitral valve prolapse (HP:0001634)2.87620137
41Progressive muscle weakness (HP:0003323)2.87132331
42Breast hypoplasia (HP:0003187)2.86656735
43Distal upper limb amyotrophy (HP:0007149)2.83149774
44Upper limb amyotrophy (HP:0009129)2.83149774
45Spinal rigidity (HP:0003306)2.78635010
46Birth length less than 3rd percentile (HP:0003561)2.78055931
47Bowel diverticulosis (HP:0005222)2.72597453
48Biconcave vertebral bodies (HP:0004586)2.71491955
49Deviation of the hallux (HP:0010051)2.67684547
50Testicular atrophy (HP:0000029)2.66385727
51Abnormality of the acetabulum (HP:0003170)2.63600760
52Reduced subcutaneous adipose tissue (HP:0003758)2.63481882
53Follicular hyperkeratosis (HP:0007502)2.63040413
54Increased connective tissue (HP:0009025)2.63037493
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61997917
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61997917
57Buphthalmos (HP:0000557)2.61329340
58Bowed forearm bones (HP:0003956)2.57678954
59Bowing of the arm (HP:0006488)2.57678954
60Aortic aneurysm (HP:0004942)2.55032797
61Hyperparathyroidism (HP:0000843)2.54683698
62Hallux valgus (HP:0001822)2.54136571
63Hyperacusis (HP:0010780)2.54115770
64Aplastic anemia (HP:0001915)2.51959185
65Ragged-red muscle fibers (HP:0003200)2.49784033
66Abnormality of the calcaneus (HP:0008364)2.48682249
67Increased density of long bones (HP:0006392)2.46770816
68Hypoplastic left heart (HP:0004383)2.46533800
69Hand muscle atrophy (HP:0009130)2.46123136
70Radial bowing (HP:0002986)2.44946001
71Slender build (HP:0001533)2.44473946
72Type 1 muscle fiber predominance (HP:0003803)2.43196030
73Congenital glaucoma (HP:0001087)2.37726837
74Short middle phalanx of the 5th finger (HP:0004220)2.36540838
75Abnormal delivery (HP:0001787)2.36061900
76Truncus arteriosus (HP:0001660)2.34192166
77Elbow flexion contracture (HP:0002987)2.32546573
78Hyperextensible skin (HP:0000974)2.31723214
79Abnormal number of incisors (HP:0011064)2.31283743
80Ureteral stenosis (HP:0000071)2.30449991
81Microvesicular hepatic steatosis (HP:0001414)2.30144383
82Rectal prolapse (HP:0002035)2.29626187
83Aneurysm (HP:0002617)2.28724658
84Tibial bowing (HP:0002982)2.27713925
85Coronal craniosynostosis (HP:0004440)2.27032408
86Mildly elevated creatine phosphokinase (HP:0008180)2.26753161
87Breech presentation (HP:0001623)2.24170231
88Mesomelia (HP:0003027)2.23551616
89Abnormalities of placenta or umbilical cord (HP:0001194)2.21418376
90Thin bony cortex (HP:0002753)2.20931488
91Hyperthyroidism (HP:0000836)2.20366067
92Turricephaly (HP:0000262)2.16908661
93Periauricular skin pits (HP:0100277)2.16884890
94Preauricular pit (HP:0004467)2.16884890
95Proximal placement of thumb (HP:0009623)2.15587981
96Short nail (HP:0001799)2.15056171
97Self-mutilation (HP:0000742)2.13703579
98Abnormality of the tricuspid valve (HP:0001702)2.13117903
99Vertebral hypoplasia (HP:0008417)2.13032069
100Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.13032069
101Short clavicles (HP:0000894)2.12371402
102Selective tooth agenesis (HP:0001592)2.12268370
103Abnormality of the Achilles tendon (HP:0005109)2.12049984
104Spinal cord compression (HP:0002176)2.10008920
105Osteolytic defects of the phalanges of the hand (HP:0009771)2.08065783
106Osteolytic defects of the hand bones (HP:0009699)2.08065783
107Abnormality of the peritoneum (HP:0002585)2.06476118
108Hydroureter (HP:0000072)2.06231637
109Hypercortisolism (HP:0001578)2.05795545
110Enlarged penis (HP:0000040)2.05621674
111Hypoplastic heart (HP:0001961)2.04508801
112Camptodactyly of toe (HP:0001836)2.02045621
113Ureteral obstruction (HP:0006000)1.99094168
114Hypokinesia (HP:0002375)1.95719370
115Dislocated radial head (HP:0003083)1.93565402
116Abnormality of the distal phalanx of the thumb (HP:0009617)1.93516986
117Joint laxity (HP:0001388)1.92973362
118Sparse eyelashes (HP:0000653)1.91060738
119Distal lower limb amyotrophy (HP:0008944)1.89111980
120Femoral bowing (HP:0002980)1.88689972
121Subacute progressive viral hepatitis (HP:0006572)1.88140093
122Missing ribs (HP:0000921)1.88103305
123Achilles tendon contracture (HP:0001771)1.87902435
124Aplasia/Hypoplasia of the clavicles (HP:0006710)1.87783105
125Sparse lateral eyebrow (HP:0005338)1.87182153
126Difficulty climbing stairs (HP:0003551)1.84784127
127Mitral regurgitation (HP:0001653)1.84763554
128Long palpebral fissure (HP:0000637)1.84355864
129Carpal synostosis (HP:0009702)1.84108815
130Increased variability in muscle fiber diameter (HP:0003557)1.82924169
131Wide anterior fontanel (HP:0000260)1.82222320
132Coxa vara (HP:0002812)1.81870306
133Atresia of the external auditory canal (HP:0000413)1.81419683
134Down-sloping shoulders (HP:0200021)1.80730444
135Infantile muscular hypotonia (HP:0008947)1.80429265
136Short 5th finger (HP:0009237)1.80108184
137Overgrowth (HP:0001548)1.79932529
138Dysautonomia (HP:0002459)1.79303780
139Patellar dislocation (HP:0002999)1.78083581
140Tarsal synostosis (HP:0008368)1.77329722
141Abnormality of the radial head (HP:0003995)1.76991982
142Multiple lipomas (HP:0001012)1.76751820
143Platyspondyly (HP:0000926)1.76711160
144Broad long bones (HP:0005622)1.76260765
145Vascular tortuosity (HP:0004948)1.75693185
146Flat acetabular roof (HP:0003180)1.75120389
147Nasolacrimal duct obstruction (HP:0000579)1.74063810
148Nonimmune hydrops fetalis (HP:0001790)1.73929334
149Spinal cord lesions (HP:0100561)1.73586722
150Syringomyelia (HP:0003396)1.73586722
151Abnormal mitochondria in muscle tissue (HP:0008316)1.72864100
152Entropion (HP:0000621)1.72850737
153Broad face (HP:0000283)1.72606004
154Asymmetry of the thorax (HP:0001555)1.71336031
155Orthostatic hypotension (HP:0001278)1.70779767
156Increased mean platelet volume (HP:0011877)1.69782566
157Generalized amyotrophy (HP:0003700)1.69637312
158Slender long bone (HP:0003100)1.69240470
159Vaginal fistula (HP:0004320)1.68830979
160Abnormality of cells of the erythroid lineage (HP:0012130)1.68371901
161Ectopia lentis (HP:0001083)1.68054816
162Fused cervical vertebrae (HP:0002949)1.67916158
163Rectal fistula (HP:0100590)1.67129207
164Rectovaginal fistula (HP:0000143)1.67129207
165Deviation of the thumb (HP:0009603)1.67047155
166Hypercalcemia (HP:0003072)1.66105999
167Rough bone trabeculation (HP:0100670)1.65402011
168Knee flexion contracture (HP:0006380)1.65269217
169Aplasia/Hypoplasia of the patella (HP:0006498)1.64416687
170Osteopenia (HP:0000938)1.64288477
171Calcaneovalgus deformity (HP:0001848)1.63907294
172Stridor (HP:0010307)1.63511969
173Intestinal fistula (HP:0100819)1.63355960
174Short thumb (HP:0009778)1.61505376
175Fasciculations (HP:0002380)1.61053532
176Type I transferrin isoform profile (HP:0003642)1.60997074
177Scapular winging (HP:0003691)1.60958508
178* Squamous cell carcinoma (HP:0002860)1.58273564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.89129014
2BUB14.35854157
3PKN24.25167210
4IRAK34.01433475
5DDR23.57991335
6SMG13.48054841
7EEF2K3.32805479
8PDGFRA3.20569499
9TTN3.08660629
10EPHA22.70511840
11ERN12.55251420
12VRK22.44226098
13KDR2.34966760
14BMX2.31457681
15LRRK22.14293066
16PAK42.04154300
17LATS11.99874680
18SCYL21.98061782
19LATS21.97454317
20CDK81.93412240
21BRSK11.91885990
22CDK121.89160620
23PAK21.83314916
24PTK61.72072029
25PTK21.69949849
26SIK11.68020064
27RIPK11.64485258
28MAP3K101.61729845
29PIM21.59751144
30PDK21.57257541
31PBK1.56738495
32FLT31.48497498
33ARAF1.42555666
34CHEK21.42040406
35MET1.34138883
36ICK1.30565485
37MOS1.29526006
38TAOK21.26627081
39BRAF1.25867623
40STK101.25095172
41NEK21.22015395
42STK31.21607039
43FER1.20861098
44TRPM71.20681572
45MTOR1.19890556
46EIF2AK11.19223484
47PASK1.18858172
48PRPF4B1.16018031
49TLK11.14055742
50TESK11.13598507
51IRAK21.10009663
52PDGFRB1.09937018
53EPHB21.09726364
54CDK61.08251755
55BCKDK1.05503533
56PAK31.04028853
57WEE11.03152340
58MAPK111.02506515
59DAPK31.00884115
60ILK0.99167416
61MAP3K80.98713917
62NTRK10.94065039
63STK40.93460832
64FGFR10.93361070
65STK160.92933637
66PRKD30.91936507
67DYRK1B0.91521175
68RPS6KA40.91127622
69TYRO30.88735894
70TESK20.88566726
71MAP2K30.88326554
72CSNK1G30.86961164
73SRPK10.82858002
74MAP2K10.81178459
75ALK0.80475338
76PIM10.80458011
77EPHB10.78377806
78RPS6KB20.77696368
79CSNK1A1L0.76474890
80LIMK10.76288944
81BRSK20.76190763
82NEK10.73918423
83CDC70.72079329
84PAK10.69991072
85TAF10.69730400
86MAP3K110.69555864
87RET0.68877457
88* ATR0.68827447
89PAK60.68522236
90CDK70.68281849
91TTK0.64831856
92TGFBR10.63930468
93NME10.63081311
94MELK0.61484105
95IRAK40.60108126
96FRK0.59062348
97CAMKK10.58885027
98RPS6KA50.58191147
99PRKD20.57589466
100ROCK20.55640732
101NME20.55525303
102INSR0.54245102
103MAPKAPK50.53525847
104AKT20.52949873
105PRKG20.52842573
106NEK90.52171488
107CAMK1D0.51340736
108PDPK10.50511190
109MAP2K20.49500404
110MAP3K30.49426408
111DAPK10.49186029
112PLK10.48409074
113CAMK1G0.48397987
114AURKB0.47735099
115VRK10.46935431
116FGR0.46839023
117CAMKK20.46068836
118ROCK10.44127964
119CDK20.44050117
120MAPKAPK20.42575257
121MAPKAPK30.40895069
122CDK10.39124390
123MAP3K130.39112206
124CSNK1G10.38334468
125CDK150.34494755
126SRC0.33499303
127PTK2B0.33040464
128CDK140.32671156
129KSR20.32551580
130CDK40.32508079
131CSNK2A10.31744133
132SIK30.31027384
133CDK11A0.30832359
134ERBB40.29483421
135MAPK10.29424794
136ABL20.29192051
137CHUK0.28541017
138CDK180.27793177
139CAMK2G0.26959932
140CSK0.26342153
141CHEK10.26203235
142MST1R0.25728933
143CDK90.25459542
144PRKCI0.24861604
145STK38L0.24468392
146PRKD10.24204770
147JAK30.23397118
148AURKA0.23366705
149GSK3A0.23026156
150MATK0.22573136
151EPHA30.22166532
152ABL10.20824134

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.11470545
2ECM-receptor interaction_Homo sapiens_hsa045123.54371082
3Ribosome_Homo sapiens_hsa030103.40289709
4* Bladder cancer_Homo sapiens_hsa052192.99160732
5Focal adhesion_Homo sapiens_hsa045102.73158679
6Small cell lung cancer_Homo sapiens_hsa052222.53877033
7Base excision repair_Homo sapiens_hsa034102.53654685
8Pyrimidine metabolism_Homo sapiens_hsa002402.51462720
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.49264066
10Proteoglycans in cancer_Homo sapiens_hsa052052.47017666
11Mismatch repair_Homo sapiens_hsa034302.35340222
12Vitamin B6 metabolism_Homo sapiens_hsa007502.30689180
13Spliceosome_Homo sapiens_hsa030402.28529843
14Proteasome_Homo sapiens_hsa030502.17228931
15* p53 signaling pathway_Homo sapiens_hsa041152.14406367
16RNA polymerase_Homo sapiens_hsa030202.09191059
17* Chronic myeloid leukemia_Homo sapiens_hsa052202.07944920
18Nucleotide excision repair_Homo sapiens_hsa034202.03035114
19* MicroRNAs in cancer_Homo sapiens_hsa052061.99138370
20Adherens junction_Homo sapiens_hsa045201.93652370
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.92653327
22Amoebiasis_Homo sapiens_hsa051461.82286467
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80974675
24Hippo signaling pathway_Homo sapiens_hsa043901.75573376
25Homologous recombination_Homo sapiens_hsa034401.74084453
26* Viral carcinogenesis_Homo sapiens_hsa052031.61118254
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.57911896
28TGF-beta signaling pathway_Homo sapiens_hsa043501.52916874
29Pentose phosphate pathway_Homo sapiens_hsa000301.50682505
30mTOR signaling pathway_Homo sapiens_hsa041501.47168142
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.43512736
32PI3K-Akt signaling pathway_Homo sapiens_hsa041511.42769549
33Folate biosynthesis_Homo sapiens_hsa007901.40751462
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40717236
35* Glioma_Homo sapiens_hsa052141.38293270
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38223500
37* Cell cycle_Homo sapiens_hsa041101.36639489
38* Melanoma_Homo sapiens_hsa052181.36546038
39One carbon pool by folate_Homo sapiens_hsa006701.34430004
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.33300077
41Oxidative phosphorylation_Homo sapiens_hsa001901.33015262
42Shigellosis_Homo sapiens_hsa051311.31588439
43Thyroid cancer_Homo sapiens_hsa052161.29170643
44Parkinsons disease_Homo sapiens_hsa050121.27496330
45Protein digestion and absorption_Homo sapiens_hsa049741.27122446
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26947600
47Prostate cancer_Homo sapiens_hsa052151.25337018
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.25118192
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22717245
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22258873
51Huntingtons disease_Homo sapiens_hsa050161.20084061
52Basal cell carcinoma_Homo sapiens_hsa052171.17527613
53Purine metabolism_Homo sapiens_hsa002301.17425060
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17273821
55Colorectal cancer_Homo sapiens_hsa052101.15632498
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13635583
57Galactose metabolism_Homo sapiens_hsa000521.13573153
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.12357677
59* Pancreatic cancer_Homo sapiens_hsa052121.12191587
60Tight junction_Homo sapiens_hsa045301.11819127
61Fanconi anemia pathway_Homo sapiens_hsa034601.08967111
62Prion diseases_Homo sapiens_hsa050201.08541116
63* HTLV-I infection_Homo sapiens_hsa051661.08423972
64Apoptosis_Homo sapiens_hsa042101.07747823
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.07393611
66* Pathways in cancer_Homo sapiens_hsa052001.05942266
67RNA transport_Homo sapiens_hsa030131.05309914
68Malaria_Homo sapiens_hsa051441.05101285
69HIF-1 signaling pathway_Homo sapiens_hsa040661.04373287
70Carbon metabolism_Homo sapiens_hsa012001.04155718
71Endometrial cancer_Homo sapiens_hsa052131.03898580
72Fructose and mannose metabolism_Homo sapiens_hsa000511.03829559
73Sulfur metabolism_Homo sapiens_hsa009201.01189483
74VEGF signaling pathway_Homo sapiens_hsa043700.99695840
75Hedgehog signaling pathway_Homo sapiens_hsa043400.99026091
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.96789825
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94313804
78mRNA surveillance pathway_Homo sapiens_hsa030150.93777338
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92247916
80Systemic lupus erythematosus_Homo sapiens_hsa053220.92095607
81Alzheimers disease_Homo sapiens_hsa050100.91210776
82Toxoplasmosis_Homo sapiens_hsa051450.90581780
83Pyruvate metabolism_Homo sapiens_hsa006200.87417565
84Dilated cardiomyopathy_Homo sapiens_hsa054140.87183336
85Platelet activation_Homo sapiens_hsa046110.85712822
86Non-homologous end-joining_Homo sapiens_hsa034500.85243599
87Hepatitis B_Homo sapiens_hsa051610.84703267
88Viral myocarditis_Homo sapiens_hsa054160.82701800
89Acute myeloid leukemia_Homo sapiens_hsa052210.82227197
90Renal cell carcinoma_Homo sapiens_hsa052110.81016885
91TNF signaling pathway_Homo sapiens_hsa046680.80103057
92Vibrio cholerae infection_Homo sapiens_hsa051100.79742130
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79053811
94Rap1 signaling pathway_Homo sapiens_hsa040150.79049012
95Lysosome_Homo sapiens_hsa041420.77452471
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76368492
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.76099304
98* Non-small cell lung cancer_Homo sapiens_hsa052230.75481539
99Estrogen signaling pathway_Homo sapiens_hsa049150.73931153
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73191728
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71646776
102FoxO signaling pathway_Homo sapiens_hsa040680.71383351
103Biosynthesis of amino acids_Homo sapiens_hsa012300.70901090
104Renin-angiotensin system_Homo sapiens_hsa046140.70723748
105Notch signaling pathway_Homo sapiens_hsa043300.69753594
106Wnt signaling pathway_Homo sapiens_hsa043100.68132179
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.67787670
108AMPK signaling pathway_Homo sapiens_hsa041520.66578961
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66206048
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66096577
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65500012
112DNA replication_Homo sapiens_hsa030300.62909536
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62729360
114Phagosome_Homo sapiens_hsa041450.62618055
115Salmonella infection_Homo sapiens_hsa051320.61863213
116ErbB signaling pathway_Homo sapiens_hsa040120.60631199
117Selenocompound metabolism_Homo sapiens_hsa004500.60470011
118Epstein-Barr virus infection_Homo sapiens_hsa051690.59206817
119Endocytosis_Homo sapiens_hsa041440.57741740
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56718588
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54966424
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54519983
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54052647
124N-Glycan biosynthesis_Homo sapiens_hsa005100.53648958
125Phenylalanine metabolism_Homo sapiens_hsa003600.53647990
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52698703
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51854557
128Insulin signaling pathway_Homo sapiens_hsa049100.50848404
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.50124405
130Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49287825
131Gap junction_Homo sapiens_hsa045400.49198363
132Axon guidance_Homo sapiens_hsa043600.49153336
133Basal transcription factors_Homo sapiens_hsa030220.48764078
134Arginine and proline metabolism_Homo sapiens_hsa003300.47983949
135Fatty acid elongation_Homo sapiens_hsa000620.47708925
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45537627
137Alcoholism_Homo sapiens_hsa050340.44955271
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.44236330
139Lysine degradation_Homo sapiens_hsa003100.43864298
140Prolactin signaling pathway_Homo sapiens_hsa049170.43437337
141Fatty acid biosynthesis_Homo sapiens_hsa000610.42973591
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42447370
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42391918
144Herpes simplex infection_Homo sapiens_hsa051680.42087783
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41669886
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.41518735
147Glutathione metabolism_Homo sapiens_hsa004800.41075291
148Other glycan degradation_Homo sapiens_hsa005110.40343599
149RNA degradation_Homo sapiens_hsa030180.40232459
150Metabolic pathways_Homo sapiens_hsa011000.38848583
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38722457
152Oocyte meiosis_Homo sapiens_hsa041140.33059603
153Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29864866
154Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28331576

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