CDKN2AIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)5.34571184
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.40609218
3DNA deamination (GO:0045006)4.24907295
4ribosomal small subunit assembly (GO:0000028)4.10442929
5sperm-egg recognition (GO:0035036)3.95933624
6fusion of sperm to egg plasma membrane (GO:0007342)3.89441728
7regulation of retinoic acid receptor signaling pathway (GO:0048385)3.84349512
8pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.80040613
9nuclear pore complex assembly (GO:0051292)3.78502283
10cell wall macromolecule metabolic process (GO:0044036)3.68361488
11cell wall macromolecule catabolic process (GO:0016998)3.68361488
12piRNA metabolic process (GO:0034587)3.68191733
13acrosome assembly (GO:0001675)3.67453889
14binding of sperm to zona pellucida (GO:0007339)3.64518768
15pyrimidine dimer repair (GO:0006290)3.61081126
16centriole replication (GO:0007099)3.53385450
17sperm motility (GO:0030317)3.51211651
18multicellular organism reproduction (GO:0032504)3.51105916
19cell-cell recognition (GO:0009988)3.49363628
20negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.49161560
21negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.49161560
22negative regulation of mitotic sister chromatid segregation (GO:0033048)3.49161560
23negative regulation of mitotic sister chromatid separation (GO:2000816)3.49161560
24negative regulation of sister chromatid segregation (GO:0033046)3.49161560
25negative regulation of meiosis (GO:0045835)3.44225729
26dosage compensation (GO:0007549)3.42893444
27mitotic spindle assembly checkpoint (GO:0007094)3.42595419
28spindle assembly checkpoint (GO:0071173)3.41126596
29DNA methylation involved in gamete generation (GO:0043046)3.38170808
30negative regulation of chromosome segregation (GO:0051985)3.37555669
31pyrimidine nucleotide catabolic process (GO:0006244)3.36098059
32mitotic spindle checkpoint (GO:0071174)3.35757073
33protein localization to chromosome (GO:0034502)3.34117582
34histone mRNA catabolic process (GO:0071044)3.34106747
35regulation of chromatin binding (GO:0035561)3.33202049
36male meiosis (GO:0007140)3.28211429
37histone H2A acetylation (GO:0043968)3.26176534
38definitive hemopoiesis (GO:0060216)3.25474479
39telomere maintenance via semi-conservative replication (GO:0032201)3.23277301
40pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.22660112
41regulation of centriole replication (GO:0046599)3.21619521
42pore complex assembly (GO:0046931)3.19759500
43chromatin remodeling at centromere (GO:0031055)3.19544191
44CENP-A containing nucleosome assembly (GO:0034080)3.18541808
45viral mRNA export from host cell nucleus (GO:0046784)3.18288706
46axonemal dynein complex assembly (GO:0070286)3.18124207
47spindle checkpoint (GO:0031577)3.15791968
48telomere maintenance via recombination (GO:0000722)3.13376824
49kinetochore organization (GO:0051383)3.12942693
50histone exchange (GO:0043486)3.12484216
51negative regulation of DNA recombination (GO:0045910)3.09120125
52meiotic cell cycle process (GO:1903046)3.09052899
53regulation of mitotic metaphase/anaphase transition (GO:0030071)3.08655395
54regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.08655395
55regulation of helicase activity (GO:0051095)3.07770812
56spermatid development (GO:0007286)3.06440620
57regulation of sister chromatid segregation (GO:0033045)3.06410335
58regulation of mitotic sister chromatid separation (GO:0010965)3.06410335
59regulation of mitotic sister chromatid segregation (GO:0033047)3.06410335
60DNA replication initiation (GO:0006270)3.04663666
61cilium or flagellum-dependent cell motility (GO:0001539)3.04501094
62protein K6-linked ubiquitination (GO:0085020)2.99742728
63regulation of DNA endoreduplication (GO:0032875)2.96907821
64DNA strand elongation involved in DNA replication (GO:0006271)2.95361972
65mitotic chromosome condensation (GO:0007076)2.94064750
66centriole assembly (GO:0098534)2.93999597
67mitotic metaphase plate congression (GO:0007080)2.93924184
68positive regulation of mitochondrial fission (GO:0090141)2.93309625
69mitotic recombination (GO:0006312)2.93259974
70spermatid nucleus differentiation (GO:0007289)2.92442272
71meiotic chromosome segregation (GO:0045132)2.91550264
72DNA strand elongation (GO:0022616)2.89841855
73base-excision repair, AP site formation (GO:0006285)2.89380589
74maturation of SSU-rRNA (GO:0030490)2.84958860
75synaptonemal complex assembly (GO:0007130)2.84834577
76synaptonemal complex organization (GO:0070193)2.84154917
77histone H3-K9 methylation (GO:0051567)2.84013246
78metaphase plate congression (GO:0051310)2.83118704
79positive regulation of granulocyte differentiation (GO:0030854)2.83038285
80kinetochore assembly (GO:0051382)2.82515880
81chromosome organization involved in meiosis (GO:0070192)2.81006021
82reproduction (GO:0000003)2.80687287
83male meiosis I (GO:0007141)2.80305886
84metallo-sulfur cluster assembly (GO:0031163)2.79035750
85iron-sulfur cluster assembly (GO:0016226)2.79035750
86tRNA methylation (GO:0030488)2.78575384
87DNA replication-independent nucleosome organization (GO:0034724)2.78389913
88DNA replication-independent nucleosome assembly (GO:0006336)2.78389913
89regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.78282689
90histone mRNA metabolic process (GO:0008334)2.76557428
91regulation of chromosome segregation (GO:0051983)2.75537113
92monoubiquitinated protein deubiquitination (GO:0035520)2.74590409
93meiotic nuclear division (GO:0007126)2.74091800
94microtubule depolymerization (GO:0007019)2.73264570
95plasma membrane fusion (GO:0045026)2.72905786
96negative regulation of nuclear division (GO:0051784)2.72626715
97peptidyl-lysine trimethylation (GO:0018023)2.70747031
98mRNA splice site selection (GO:0006376)2.70389664
99DNA demethylation (GO:0080111)2.70209470
100DNA synthesis involved in DNA repair (GO:0000731)2.69554717
101regulation of mitotic spindle checkpoint (GO:1903504)2.69390253
102regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.69390253
103negative regulation of mitosis (GO:0045839)2.67810534
104histone H3-K9 demethylation (GO:0033169)2.66143436
105DNA replication checkpoint (GO:0000076)2.65041755
106intra-S DNA damage checkpoint (GO:0031573)2.65032114
107RNA destabilization (GO:0050779)2.63596994
108DNA integration (GO:0015074)2.61267241
109histone H3-K9 modification (GO:0061647)2.61028616
110sister chromatid cohesion (GO:0007062)2.60980800
111translesion synthesis (GO:0019985)2.60081702
112epithelial cilium movement (GO:0003351)2.59228601
113exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58887066
114negative regulation of erythrocyte differentiation (GO:0045647)2.56340172
115histone lysine demethylation (GO:0070076)2.55874278
116protein K11-linked ubiquitination (GO:0070979)2.55810423
117microtubule polymerization or depolymerization (GO:0031109)2.54913830
118negative regulation of cell division (GO:0051782)2.54249384
119regulation of meiosis I (GO:0060631)2.54206403
120postreplication repair (GO:0006301)2.54152906
121RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53474440
122positive regulation of B cell differentiation (GO:0045579)2.52961965
123regulation of histone H3-K9 methylation (GO:0051570)2.52608917
124negative regulation of meiotic cell cycle (GO:0051447)2.52298323
125histone demethylation (GO:0016577)2.52116874
126response to interferon-beta (GO:0035456)2.51937387
127viral transcription (GO:0019083)2.49265464
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.48077331
129spliceosomal snRNP assembly (GO:0000387)2.47993030
130nucleotide-excision repair, DNA gap filling (GO:0006297)2.47488731
131production of molecular mediator involved in inflammatory response (GO:0002532)2.47218001
132establishment of chromosome localization (GO:0051303)2.47107456
133termination of RNA polymerase II transcription (GO:0006369)2.47066074
134reciprocal DNA recombination (GO:0035825)2.47048646
135reciprocal meiotic recombination (GO:0007131)2.47048646
136facial nerve structural organization (GO:0021612)2.46872564
137telomere maintenance via telomere lengthening (GO:0010833)2.46379107
138telomere maintenance (GO:0000723)2.45124736
139ATP-dependent chromatin remodeling (GO:0043044)2.44839948
140telomere organization (GO:0032200)2.44684865
141nuclear pore organization (GO:0006999)2.44252598
142deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.43595830
143motile cilium assembly (GO:0044458)2.43444838
144neural tube formation (GO:0001841)2.42917786
145meiotic cell cycle (GO:0051321)2.42482577
146DNA ligation (GO:0006266)2.41171194
147proteasome assembly (GO:0043248)2.40286590
148meiosis I (GO:0007127)2.39939091
149antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.39923729
150acrosome reaction (GO:0007340)2.39876503
151single fertilization (GO:0007338)2.38667960
152regulation of cilium movement (GO:0003352)2.38307489
153mitotic sister chromatid cohesion (GO:0007064)2.37013168
154translational termination (GO:0006415)2.36536021
155ribosome biogenesis (GO:0042254)2.36350431
156transcription-coupled nucleotide-excision repair (GO:0006283)2.36174283
157nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.36157992
158DNA-templated transcription, termination (GO:0006353)2.34716735
159attachment of spindle microtubules to kinetochore (GO:0008608)2.34521496
160transcription from RNA polymerase I promoter (GO:0006360)2.34121447
161nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.33702468
162epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.33686929
163regulation of double-strand break repair via homologous recombination (GO:0010569)2.32584212
164DNA packaging (GO:0006323)2.31528648
165mismatch repair (GO:0006298)2.31403742
166protein localization to chromosome, centromeric region (GO:0071459)2.30290346

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.07796319
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.88560643
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33431735
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.99022190
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.95648437
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87371609
7IGF1R_20145208_ChIP-Seq_DFB_Human2.54724694
8* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35485290
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34060158
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.33199570
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.32157978
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.31861590
13SCL_19346495_ChIP-Seq_HPC-7_Human2.30673443
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29433986
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.28299110
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.26271188
17VDR_23849224_ChIP-Seq_CD4+_Human2.25223766
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22930134
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.15091918
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10506225
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07738957
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06588161
23TAF15_26573619_Chip-Seq_HEK293_Human2.04317824
24HOXB4_20404135_ChIP-ChIP_EML_Mouse2.02442314
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.02197208
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01406450
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00354795
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99662413
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96025461
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93817713
31FOXP3_21729870_ChIP-Seq_TREG_Human1.93143693
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87836810
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.84229409
34ZNF274_21170338_ChIP-Seq_K562_Hela1.83581612
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81293851
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79566264
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75017953
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.74142563
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73677308
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.72262659
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.71603435
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70440885
43* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70193080
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70104030
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69936524
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69121179
47EWS_26573619_Chip-Seq_HEK293_Human1.67418827
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61622860
49ELK1_19687146_ChIP-ChIP_HELA_Human1.60771728
50XRN2_22483619_ChIP-Seq_HELA_Human1.58718257
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55026862
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53579648
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53123535
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52625457
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51605735
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49276840
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.48542437
58FUS_26573619_Chip-Seq_HEK293_Human1.46914094
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46476662
60DCP1A_22483619_ChIP-Seq_HELA_Human1.46190508
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44783427
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.43728068
63MYC_22102868_ChIP-Seq_BL_Human1.40297264
64MYB_26560356_Chip-Seq_TH2_Human1.38773241
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37212771
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36991388
67* SPI1_23547873_ChIP-Seq_NB4_Human1.36974919
68* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36014633
69TTF2_22483619_ChIP-Seq_HELA_Human1.35900041
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35206478
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34363470
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.33732355
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33509491
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33403323
75IRF1_19129219_ChIP-ChIP_H3396_Human1.32825767
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.31854417
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31331037
78* GABP_19822575_ChIP-Seq_HepG2_Human1.30800645
79KAP1_22055183_ChIP-Seq_ESCs_Mouse1.30072607
80TFEB_21752829_ChIP-Seq_HELA_Human1.29156962
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29142314
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26970666
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.25556393
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25114088
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23351562
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22978884
87MYC_18940864_ChIP-ChIP_HL60_Human1.21278074
88CIITA_25753668_ChIP-Seq_RAJI_Human1.20199522
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17964502
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17864953
91* MYB_26560356_Chip-Seq_TH1_Human1.16777429
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16700486
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16042966
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14185265
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12924685
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12004381
97* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11977286
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11917000
99STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11382369
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10268250
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09564059
102AR_21909140_ChIP-Seq_LNCAP_Human1.08141091
103PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07878583
104IRF8_21731497_ChIP-ChIP_J774_Mouse1.06522361
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05080119
106POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04091330
107YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02030730
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00984154
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00768485
110PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97422075
111* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.96741639
112STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95969924
113RNF2_27304074_Chip-Seq_NSC_Mouse0.95640689
114NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94377745
115RUNX1_22412390_ChIP-Seq_EML_Mouse0.94285465
116GATA3_27048872_Chip-Seq_THYMUS_Human0.93504842
117SOX2_16153702_ChIP-ChIP_HESCs_Human0.92030241
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91884206
119* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91878464
120PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91800557
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91728021
122GATA3_26560356_Chip-Seq_TH2_Human0.90620940
123SALL4_22934838_ChIP-ChIP_CD34+_Human0.89218859
124WT1_19549856_ChIP-ChIP_CCG9911_Human0.88989235
125KDM5A_27292631_Chip-Seq_BREAST_Human0.85486291
126NFE2_27457419_Chip-Seq_LIVER_Mouse0.84740198
127GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84513933
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84190210
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84186297
130* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84117843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability2.99193278
2MP0008058_abnormal_DNA_repair2.92617222
3MP0005410_abnormal_fertilization2.87169185
4MP0002102_abnormal_ear_morphology2.82929669
5MP0003693_abnormal_embryo_hatching2.80370607
6MP0006292_abnormal_olfactory_placode2.76640835
7MP0008007_abnormal_cellular_replicative2.62123198
8MP0008877_abnormal_DNA_methylation2.52494655
9MP0008789_abnormal_olfactory_epithelium2.46645679
10MP0005499_abnormal_olfactory_system2.42635308
11MP0005394_taste/olfaction_phenotype2.42635308
12MP0002396_abnormal_hematopoietic_system2.28388443
13MP0003763_abnormal_thymus_physiology2.25588650
14MP0003077_abnormal_cell_cycle2.16071546
15MP0002009_preneoplasia2.13048065
16MP0001929_abnormal_gametogenesis2.12663081
17MP0005671_abnormal_response_to2.11279026
18MP0002210_abnormal_sex_determination2.08684250
19MP0006054_spinal_hemorrhage2.07958427
20MP0004808_abnormal_hematopoietic_stem2.02923945
21MP0003111_abnormal_nucleus_morphology2.00241549
22MP0003724_increased_susceptibility_to1.99782909
23MP0001835_abnormal_antigen_presentation1.92772588
24MP0003787_abnormal_imprinting1.87853087
25MP0003221_abnormal_cardiomyocyte_apopto1.84666000
26MP0004957_abnormal_blastocyst_morpholog1.84590364
27MP0003656_abnormal_erythrocyte_physiolo1.83109735
28MP0005075_abnormal_melanosome_morpholog1.82567459
29MP0000685_abnormal_immune_system1.80471248
30MP0005174_abnormal_tail_pigmentation1.79481932
31MP0002132_abnormal_respiratory_system1.76362881
32MP0008057_abnormal_DNA_replication1.75937313
33MP0009785_altered_susceptibility_to1.75717546
34MP0003698_abnormal_male_reproductive1.69974718
35MP0001873_stomach_inflammation1.69263167
36MP0000490_abnormal_crypts_of1.68741549
37MP0002398_abnormal_bone_marrow1.62587561
38MP0003786_premature_aging1.60776393
39MP0001145_abnormal_male_reproductive1.60282338
40MP0003880_abnormal_central_pattern1.59178552
41MP0009333_abnormal_splenocyte_physiolog1.58124760
42MP0000566_synostosis1.57851954
43MP0000465_gastrointestinal_hemorrhage1.53248027
44MP0000653_abnormal_sex_gland1.51191746
45MP0002166_altered_tumor_susceptibility1.50354031
46MP0004147_increased_porphyrin_level1.49739985
47MP0005397_hematopoietic_system_phenotyp1.49584481
48MP0001545_abnormal_hematopoietic_system1.49584481
49MP0003943_abnormal_hepatobiliary_system1.40817225
50MP0003136_yellow_coat_color1.40773322
51MP0002095_abnormal_skin_pigmentation1.39165204
52MP0001800_abnormal_humoral_immune1.38119733
53MP0000689_abnormal_spleen_morphology1.36278710
54MP0006035_abnormal_mitochondrial_morpho1.35952372
55MP0001119_abnormal_female_reproductive1.34514396
56MP0002722_abnormal_immune_system1.30029781
57MP0002420_abnormal_adaptive_immunity1.29743508
58MP0002723_abnormal_immune_serum1.28618639
59MP0001819_abnormal_immune_cell1.28438772
60MP0002452_abnormal_antigen_presenting1.24278724
61MP0000716_abnormal_immune_system1.23775003
62MP0003890_abnormal_embryonic-extraembry1.22618556
63MP0006276_abnormal_autonomic_nervous1.21820250
64MP0000703_abnormal_thymus_morphology1.19970880
65MP0008961_abnormal_basal_metabolism1.19912323
66MP0002429_abnormal_blood_cell1.19121374
67MP0005083_abnormal_biliary_tract1.18867646
68MP0001529_abnormal_vocalization1.18456193
69MP0001986_abnormal_taste_sensitivity1.17568479
70MP0006072_abnormal_retinal_apoptosis1.17463253
71MP0000015_abnormal_ear_pigmentation1.17454868
72MP0002019_abnormal_tumor_incidence1.15429886
73MP0005025_abnormal_response_to1.14324477
74MP0001919_abnormal_reproductive_system1.13973037
75MP0009697_abnormal_copulation1.13765285
76MP0001730_embryonic_growth_arrest1.12449673
77MP0005389_reproductive_system_phenotype1.08603741
78MP0000358_abnormal_cell_content/1.08035478
79MP0003718_maternal_effect1.07552772
80MP0004381_abnormal_hair_follicle1.07129350
81MP0005000_abnormal_immune_tolerance1.07078419
82MP0002006_tumorigenesis1.06480806
83MP0000569_abnormal_digit_pigmentation1.03695812
84MP0001293_anophthalmia1.02964398
85MP0001286_abnormal_eye_development1.02940370
86MP0009840_abnormal_foam_cell1.02899311
87MP0002160_abnormal_reproductive_system1.01426575
88MP0005464_abnormal_platelet_physiology1.01420498
89MP0002148_abnormal_hypersensitivity_rea1.00706435
90MP0000313_abnormal_cell_death0.98961501
91MP0002163_abnormal_gland_morphology0.97666754
92MP0000350_abnormal_cell_proliferation0.97633552
93MP0002161_abnormal_fertility/fecundity0.97023272
94MP0005257_abnormal_intraocular_pressure0.96611783
95MP0005377_hearing/vestibular/ear_phenot0.96560976
96MP0003878_abnormal_ear_physiology0.96560976
97MP0003436_decreased_susceptibility_to0.94408950
98MP0008995_early_reproductive_senescence0.93500669
99MP0003121_genomic_imprinting0.92427248
100MP0008932_abnormal_embryonic_tissue0.92083946
101MP0010155_abnormal_intestine_physiology0.91770128
102MP0010368_abnormal_lymphatic_system0.90934284
103MP0001188_hyperpigmentation0.90176134
104MP0001853_heart_inflammation0.89927180
105MP0005670_abnormal_white_adipose0.89394761
106MP0002405_respiratory_system_inflammati0.87830763
107MP0004782_abnormal_surfactant_physiolog0.86391531
108MP0010307_abnormal_tumor_latency0.86119661
109MP0003011_delayed_dark_adaptation0.85954238
110MP0005187_abnormal_penis_morphology0.85624527
111MP0001697_abnormal_embryo_size0.85608588
112MP0002419_abnormal_innate_immunity0.84436444
113MP0001764_abnormal_homeostasis0.83300548
114MP0006036_abnormal_mitochondrial_physio0.82777305
115MP0008260_abnormal_autophagy0.81684686
116MP0000631_abnormal_neuroendocrine_gland0.80050841
117MP0000516_abnormal_urinary_system0.79777729
118MP0005367_renal/urinary_system_phenotyp0.79777729
119MP0000372_irregular_coat_pigmentation0.79315965
120MP0002249_abnormal_larynx_morphology0.78691763
121MP0003828_pulmonary_edema0.78073561
122MP0000681_abnormal_thyroid_gland0.77622453
123MP0004142_abnormal_muscle_tone0.77538816
124MP0000049_abnormal_middle_ear0.76696327
125MP0003315_abnormal_perineum_morphology0.75086318
126MP0001845_abnormal_inflammatory_respons0.74160734
127MP0005084_abnormal_gallbladder_morpholo0.73571562
128MP0008004_abnormal_stomach_pH0.73187157
129MP0003699_abnormal_female_reproductive0.72653461
130MP0005408_hypopigmentation0.72545407
131MP0004197_abnormal_fetal_growth/weight/0.72345829
132MP0001672_abnormal_embryogenesis/_devel0.72149604
133MP0005380_embryogenesis_phenotype0.72149604
134MP0005384_cellular_phenotype0.71579082
135MP0009765_abnormal_xenobiotic_induced0.71553902
136MP0005647_abnormal_sex_gland0.71271402
137MP0002233_abnormal_nose_morphology0.71244458
138MP0001790_abnormal_immune_system0.71234168
139MP0005387_immune_system_phenotype0.71234168

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.21329128
2Amyotrophic lateral sclerosis (HP:0007354)3.93228421
3Prostate neoplasm (HP:0100787)3.70015026
4Shoulder girdle muscle weakness (HP:0003547)3.61704520
5Abnormal number of erythroid precursors (HP:0012131)3.57746427
6Volvulus (HP:0002580)3.55020333
7Abnormal spermatogenesis (HP:0008669)3.49546542
8Abnormality of cells of the erythroid lineage (HP:0012130)3.44076135
9Absent/shortened dynein arms (HP:0200106)3.42592362
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.42592362
11Cortical dysplasia (HP:0002539)3.42332710
12Abnormality of the labia minora (HP:0012880)3.25146041
13Type 2 muscle fiber atrophy (HP:0003554)3.18216278
14Rimmed vacuoles (HP:0003805)3.08723331
15Atrophy/Degeneration involving motor neurons (HP:0007373)3.07920450
16Abnormality of the prostate (HP:0008775)2.99039292
17Muscle fiber atrophy (HP:0100295)2.98306497
18Aplastic anemia (HP:0001915)2.98292995
19Birth length less than 3rd percentile (HP:0003561)2.92044185
20Azoospermia (HP:0000027)2.89646908
21Abnormal respiratory motile cilium morphology (HP:0005938)2.77882788
22Abnormal respiratory epithelium morphology (HP:0012253)2.77882788
23Recurrent bronchitis (HP:0002837)2.76496337
24Supernumerary spleens (HP:0009799)2.72547901
25Abnormality of the lower motor neuron (HP:0002366)2.64510362
26Bronchitis (HP:0012387)2.63583980
27Abnormality of chromosome stability (HP:0003220)2.61689057
28Abnormality of the corticospinal tract (HP:0002492)2.56415246
29Microvesicular hepatic steatosis (HP:0001414)2.56216972
30Chromsome breakage (HP:0040012)2.53831076
31Nephrogenic diabetes insipidus (HP:0009806)2.53801214
32Medulloblastoma (HP:0002885)2.53203832
33Thrombocytosis (HP:0001894)2.52117859
34Congenital primary aphakia (HP:0007707)2.49571968
35Reduced antithrombin III activity (HP:0001976)2.47781914
36Meckel diverticulum (HP:0002245)2.46703994
37Abnormal respiratory motile cilium physiology (HP:0012261)2.46552213
38Myelodysplasia (HP:0002863)2.45747913
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.44907783
40Chronic bronchitis (HP:0004469)2.44215444
41Type I transferrin isoform profile (HP:0003642)2.43362467
42Pelvic girdle muscle weakness (HP:0003749)2.40147156
43True hermaphroditism (HP:0010459)2.39655468
4411 pairs of ribs (HP:0000878)2.37123721
45Basal cell carcinoma (HP:0002671)2.36972347
46Tubulointerstitial nephritis (HP:0001970)2.36074514
47Carpal bone hypoplasia (HP:0001498)2.35380125
48Poikilocytosis (HP:0004447)2.35133966
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.33989701
50Degeneration of the lateral corticospinal tracts (HP:0002314)2.33989701
51IgM deficiency (HP:0002850)2.33071654
52Petechiae (HP:0000967)2.33058717
53Severe visual impairment (HP:0001141)2.32798304
54Reticulocytopenia (HP:0001896)2.32668604
55Abnormality of the ileum (HP:0001549)2.30530013
56Selective tooth agenesis (HP:0001592)2.29987788
57Myositis (HP:0100614)2.29095233
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.28299380
59Prolonged bleeding time (HP:0003010)2.27393255
60Nasal polyposis (HP:0100582)2.26426555
61Abnormality of T cell physiology (HP:0011840)2.26217680
62Abnormality of the heme biosynthetic pathway (HP:0010472)2.25133065
63Spinal cord lesions (HP:0100561)2.24809547
64Syringomyelia (HP:0003396)2.24809547
65Abnormality of the preputium (HP:0100587)2.24774903
66Recurrent sinusitis (HP:0011108)2.23896171
67Pancreatic fibrosis (HP:0100732)2.22720812
68Nonprogressive disorder (HP:0003680)2.22485833
69Gait imbalance (HP:0002141)2.22328765
70Papillary thyroid carcinoma (HP:0002895)2.21447921
71Chronic hepatic failure (HP:0100626)2.21039837
72Gonadotropin excess (HP:0000837)2.19976332
73Abnormality of the musculature of the pelvis (HP:0001469)2.19510691
74Abnormality of the hip-girdle musculature (HP:0001445)2.19510691
75Abnormal protein N-linked glycosylation (HP:0012347)2.18088445
76Abnormal protein glycosylation (HP:0012346)2.18088445
77Abnormal glycosylation (HP:0012345)2.18088445
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18088445
79Rhinitis (HP:0012384)2.17959923
80Abnormal lung lobation (HP:0002101)2.17386424
81Clubbing of toes (HP:0100760)2.16807777
82Facial hemangioma (HP:0000329)2.16197131
83Dyskinesia (HP:0100660)2.13596224
84Bronchiectasis (HP:0002110)2.13305331
85Pancreatic cysts (HP:0001737)2.13042183
86Nephronophthisis (HP:0000090)2.10115198
87Thyroid carcinoma (HP:0002890)2.09582511
88Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09316449
89Abnormality of male internal genitalia (HP:0000022)2.08714438
90B lymphocytopenia (HP:0010976)2.07466977
91Abnormality of B cell number (HP:0010975)2.07466977
92T lymphocytopenia (HP:0005403)2.06544531
93Stomach cancer (HP:0012126)2.06452232
94Attenuation of retinal blood vessels (HP:0007843)2.03733596
95Abnormal rod and cone electroretinograms (HP:0008323)2.03355658
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03271832
97Abnormality of alanine metabolism (HP:0010916)2.03271832
98Hyperalaninemia (HP:0003348)2.03271832
99Retrobulbar optic neuritis (HP:0100654)2.02601804
100Optic neuritis (HP:0100653)2.02601804
101Long clavicles (HP:0000890)2.00200019
102Abnormality of T cell number (HP:0011839)1.99492839
103Combined immunodeficiency (HP:0005387)1.98633670
104Abnormality of T cells (HP:0002843)1.96558049
105Small intestinal stenosis (HP:0012848)1.95787708
106Duodenal stenosis (HP:0100867)1.95787708
107Dyschromatopsia (HP:0007641)1.94870517
108Nephroblastoma (Wilms tumor) (HP:0002667)1.93383457
109Abnormality of the nasal mucosa (HP:0000433)1.93287234
110Oligodactyly (hands) (HP:0001180)1.92963407
111Premature ovarian failure (HP:0008209)1.92836578
112Hypoplastic iliac wings (HP:0002866)1.92732939
113Acute myeloid leukemia (HP:0004808)1.91314459
114Abnormal biliary tract physiology (HP:0012439)1.91159212
115Bile duct proliferation (HP:0001408)1.91159212
116Abnormality of the anterior horn cell (HP:0006802)1.91105996
117Degeneration of anterior horn cells (HP:0002398)1.91105996
118Sloping forehead (HP:0000340)1.89777016
119Molar tooth sign on MRI (HP:0002419)1.89758329
120Abnormality of midbrain morphology (HP:0002418)1.89758329
121Abnormal ciliary motility (HP:0012262)1.87944413
122Colon cancer (HP:0003003)1.85808327
123Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.85375756
124Amaurosis fugax (HP:0100576)1.85121418
125Absent thumb (HP:0009777)1.84906886
126Stomatitis (HP:0010280)1.84615547
127Severe combined immunodeficiency (HP:0004430)1.83648281
128Medial flaring of the eyebrow (HP:0010747)1.81077762
129Congenital, generalized hypertrichosis (HP:0004540)1.80908979
130Elevated erythrocyte sedimentation rate (HP:0003565)1.80789206
131Abnormality of eosinophils (HP:0001879)1.80699295
132Microretrognathia (HP:0000308)1.79465036
133Patellar aplasia (HP:0006443)1.79398754
134Abnormality of lateral ventricle (HP:0030047)1.79363389
135Embryonal renal neoplasm (HP:0011794)1.79316827
136Capillary hemangiomas (HP:0005306)1.78906828
137Lymphoma (HP:0002665)1.78058615
138Impulsivity (HP:0100710)1.77059602
139Abnormality of the duodenum (HP:0002246)1.76627067
140Panhypogammaglobulinemia (HP:0003139)1.76209625
141Pallor (HP:0000980)1.75738966
142Sparse eyelashes (HP:0000653)1.74738422
143Abnormality of the renal medulla (HP:0100957)1.74484099
144Abnormality of the fingertips (HP:0001211)1.74327590
145Thyroiditis (HP:0100646)1.73718885
146Median cleft lip (HP:0000161)1.73391798
147Chronic otitis media (HP:0000389)1.73296754
148Intestinal atresia (HP:0011100)1.73176333
149Lissencephaly (HP:0001339)1.73081626
150Cerebellar dysplasia (HP:0007033)1.71630053
151Acute hepatic failure (HP:0006554)1.67505189
152Retinal dysplasia (HP:0007973)1.66678463
153Vaginal atresia (HP:0000148)1.66373848
154Male infertility (HP:0003251)1.66298894
155Paralysis (HP:0003470)1.66153759
156Acanthocytosis (HP:0001927)1.65890400
157Cystic hygroma (HP:0000476)1.65726289
158Biliary tract neoplasm (HP:0100574)1.65567422
159Reticulocytosis (HP:0001923)1.64835246
160Genital tract atresia (HP:0001827)1.64557095
161Stenosis of the external auditory canal (HP:0000402)1.64069644
162Poor coordination (HP:0002370)1.63452419
163Specific learning disability (HP:0001328)1.63208049
164Increased IgM level (HP:0003496)1.63071962
165Abnormality of the pons (HP:0007361)1.62937723
166Limb hypertonia (HP:0002509)1.61281633
167Decreased activity of mitochondrial respiratory chain (HP:0008972)1.61054605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.88467709
2ACVR1B3.81219139
3MUSK3.23641909
4CDK193.19295075
5BRD43.18176361
6SRPK13.17829898
7PIM22.78580696
8MST1R2.73350582
9STK162.65719188
10MKNK12.56097766
11MKNK22.52814887
12MAP3K42.47870870
13WEE12.47624028
14DYRK32.16692955
15NLK2.08668639
16CDC72.07499612
17BCR2.05081441
18BUB12.02194832
19IRAK41.94257647
20TXK1.80112603
21PIK3CA1.73611110
22VRK11.69893283
23TEC1.63616411
24TGFBR11.62971618
25PLK41.55811983
26NME21.53169488
27TESK21.52365824
28BRSK21.47328241
29NEK21.47318868
30RPS6KA41.42874007
31KIT1.42815349
32EEF2K1.42440773
33BTK1.38687776
34TNIK1.38405011
35CDK121.37587731
36IKBKE1.36185190
37PRPF4B1.36142768
38IRAK11.33661229
39MAP4K11.33105890
40SIK31.31087665
41MAP3K51.29073691
42RAF11.25407225
43MAPKAPK31.22546729
44TLK11.21450089
45PIM11.21129204
46FLT31.20327038
47ATR1.15457518
48CDK81.15450175
49CCNB11.15392022
50CDK31.14551670
51TGFBR21.10773973
52CDK91.08585268
53CHEK21.08053958
54CDK41.06474635
55PDK31.05572621
56PDK41.05572621
57TBK11.05505051
58EPHA31.04704670
59PASK1.04444291
60MAP3K141.02973173
61ZAK1.01362372
62IRAK20.99568726
63YES10.98774444
64JAK30.97818311
65ZAP700.97622694
66EIF2AK30.97478739
67TSSK60.96812333
68MAP2K20.96103791
69AURKB0.93949051
70MAPK130.93427828
71PLK10.92879301
72EIF2AK20.90888598
73BMPR1B0.90141746
74CDK70.90080823
75KDR0.89693669
76EIF2AK10.87870498
77RPS6KB20.87338765
78ERBB30.85807960
79TAOK10.80235272
80CHUK0.78155639
81WNK30.77722660
82IRAK30.75743188
83IKBKB0.75742555
84TTK0.75526300
85MAP4K20.74184559
86STK100.73704879
87DYRK1A0.73564092
88PNCK0.71243117
89AKT30.70767043
90TIE10.69573442
91CLK10.69055240
92SYK0.68905830
93OXSR10.66482710
94NEK60.66397137
95RPS6KA50.66026343
96MAP3K20.65397252
97PLK30.65367198
98MAPKAPK50.64698668
99UHMK10.62941692
100TYK20.62408947
101GRK10.61254949
102FGR0.61047443
103BRSK10.59793043
104DYRK1B0.59389737
105NUAK10.58536033
106TAOK20.57697599
107CDK60.57217732
108LYN0.56036089
109MST40.55749135
110DYRK20.55654049
111TAOK30.55477149
112CSNK2A10.55072531
113PDK20.54709685
114ATM0.54033935
115SIK20.53714881
116CASK0.52738663
117CAMKK20.52352870
118MARK30.52202625
119CDK20.52193934
120MAP3K100.52131690
121PRKG20.51960551
122MAPK150.51093491
123STK40.49966460
124JAK20.49167752
125MAP2K40.48192812
126HCK0.48018642
127GRK70.47306686
128RPS6KA10.44931231
129MAP2K70.44912801
130CSF1R0.44072089
131MAP2K30.42889557
132BRAF0.42445811
133LCK0.42032522
134MAPK90.41871819
135TESK10.41779074
136STK38L0.41651579
137CHEK10.41345342
138MAP3K110.40821531
139ADRBK20.40120413
140AURKA0.39885939
141PIK3CG0.39716904
142PRKCQ0.38090421
143MATK0.37756075
144CSNK1G20.35025199
145PLK20.33397937
146CDK10.32252771
147EPHA40.30672017

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.84126251
2Base excision repair_Homo sapiens_hsa034103.07618260
3Spliceosome_Homo sapiens_hsa030403.02512132
4Mismatch repair_Homo sapiens_hsa034302.91586051
5Homologous recombination_Homo sapiens_hsa034402.86344660
6Basal transcription factors_Homo sapiens_hsa030222.71382532
7Fanconi anemia pathway_Homo sapiens_hsa034602.60958730
8Ribosome_Homo sapiens_hsa030102.58607161
9RNA polymerase_Homo sapiens_hsa030202.55657722
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.46393925
11Nucleotide excision repair_Homo sapiens_hsa034202.33051758
12RNA transport_Homo sapiens_hsa030132.23760451
13Cell cycle_Homo sapiens_hsa041102.21504356
14Pyrimidine metabolism_Homo sapiens_hsa002402.17682473
15RNA degradation_Homo sapiens_hsa030182.02265226
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89547082
17Non-homologous end-joining_Homo sapiens_hsa034501.88238513
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.85550502
19Proteasome_Homo sapiens_hsa030501.77468415
20Herpes simplex infection_Homo sapiens_hsa051681.70781096
21Primary immunodeficiency_Homo sapiens_hsa053401.65203461
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61051137
23p53 signaling pathway_Homo sapiens_hsa041151.60959082
24Purine metabolism_Homo sapiens_hsa002301.44495070
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.44132348
26One carbon pool by folate_Homo sapiens_hsa006701.41368170
27Dorso-ventral axis formation_Homo sapiens_hsa043201.36311368
28Systemic lupus erythematosus_Homo sapiens_hsa053221.32591713
29mRNA surveillance pathway_Homo sapiens_hsa030151.30584461
30Protein export_Homo sapiens_hsa030601.27868723
31Antigen processing and presentation_Homo sapiens_hsa046121.27867621
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26755395
33Selenocompound metabolism_Homo sapiens_hsa004501.26500825
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.22650817
35Measles_Homo sapiens_hsa051621.21807927
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20239086
37Circadian rhythm_Homo sapiens_hsa047101.20196220
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.19431914
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12553720
40Thyroid cancer_Homo sapiens_hsa052161.08939563
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08610303
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05025943
43Folate biosynthesis_Homo sapiens_hsa007901.00712494
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00345074
45Legionellosis_Homo sapiens_hsa051340.98665431
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97875244
47Epstein-Barr virus infection_Homo sapiens_hsa051690.95494120
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93808664
49Collecting duct acid secretion_Homo sapiens_hsa049660.93616348
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91208622
51Hematopoietic cell lineage_Homo sapiens_hsa046400.90674081
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90027169
53Fatty acid elongation_Homo sapiens_hsa000620.89046186
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87996528
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86087242
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.82572079
57Influenza A_Homo sapiens_hsa051640.80468586
58Viral carcinogenesis_Homo sapiens_hsa052030.77932759
59Leishmaniasis_Homo sapiens_hsa051400.76692474
60FoxO signaling pathway_Homo sapiens_hsa040680.76443788
61Allograft rejection_Homo sapiens_hsa053300.75774128
62Vitamin B6 metabolism_Homo sapiens_hsa007500.74079274
63Hepatitis B_Homo sapiens_hsa051610.73090905
64HTLV-I infection_Homo sapiens_hsa051660.72782594
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72449661
66Chemokine signaling pathway_Homo sapiens_hsa040620.69514745
67B cell receptor signaling pathway_Homo sapiens_hsa046620.66902438
68TGF-beta signaling pathway_Homo sapiens_hsa043500.65910228
69Pentose phosphate pathway_Homo sapiens_hsa000300.64982181
70Acute myeloid leukemia_Homo sapiens_hsa052210.64213580
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63964233
72Sulfur relay system_Homo sapiens_hsa041220.62835367
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62188077
74Salmonella infection_Homo sapiens_hsa051320.61909661
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.61240920
76Graft-versus-host disease_Homo sapiens_hsa053320.57556372
77Phototransduction_Homo sapiens_hsa047440.57025881
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56943587
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56474329
80Shigellosis_Homo sapiens_hsa051310.56347787
81Apoptosis_Homo sapiens_hsa042100.54570561
82T cell receptor signaling pathway_Homo sapiens_hsa046600.53154860
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52769230
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.52657765
85Notch signaling pathway_Homo sapiens_hsa043300.51672449
86N-Glycan biosynthesis_Homo sapiens_hsa005100.51450488
87ABC transporters_Homo sapiens_hsa020100.51341919
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50948002
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49196005
90Pancreatic cancer_Homo sapiens_hsa052120.47379899
91Propanoate metabolism_Homo sapiens_hsa006400.45741042
92Arachidonic acid metabolism_Homo sapiens_hsa005900.44836177
93Toxoplasmosis_Homo sapiens_hsa051450.44253284
94Osteoclast differentiation_Homo sapiens_hsa043800.42741890
95Platelet activation_Homo sapiens_hsa046110.42577255
96Vitamin digestion and absorption_Homo sapiens_hsa049770.41477314
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41342072
98Rheumatoid arthritis_Homo sapiens_hsa053230.41169978
99Phagosome_Homo sapiens_hsa041450.41084042
100Oocyte meiosis_Homo sapiens_hsa041140.40773625
101Other glycan degradation_Homo sapiens_hsa005110.40755227
102Small cell lung cancer_Homo sapiens_hsa052220.40665131
103Renal cell carcinoma_Homo sapiens_hsa052110.40325761
104Regulation of autophagy_Homo sapiens_hsa041400.40107282
105Autoimmune thyroid disease_Homo sapiens_hsa053200.39892328
106mTOR signaling pathway_Homo sapiens_hsa041500.39555645
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39199581
108TNF signaling pathway_Homo sapiens_hsa046680.38756153
109Endocytosis_Homo sapiens_hsa041440.38199498
110Chronic myeloid leukemia_Homo sapiens_hsa052200.38122526
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.36521455
112Alcoholism_Homo sapiens_hsa050340.35057817
113Inositol phosphate metabolism_Homo sapiens_hsa005620.34673884
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34008306
115ErbB signaling pathway_Homo sapiens_hsa040120.33927869
116Colorectal cancer_Homo sapiens_hsa052100.33755675
117Retinol metabolism_Homo sapiens_hsa008300.33623284
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33080182
119Prostate cancer_Homo sapiens_hsa052150.31709707
120Malaria_Homo sapiens_hsa051440.30640484
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30249231
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29807773
123Prolactin signaling pathway_Homo sapiens_hsa049170.29107582
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28769927
125Pertussis_Homo sapiens_hsa051330.28243224
126Asthma_Homo sapiens_hsa053100.27744313
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27362083
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25832899
129Non-small cell lung cancer_Homo sapiens_hsa052230.25820135
130Viral myocarditis_Homo sapiens_hsa054160.24720629
131Hepatitis C_Homo sapiens_hsa051600.24534741
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23727989
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23255857
134Endometrial cancer_Homo sapiens_hsa052130.21605729

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