CDKN2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)5.30702968
2desmosome organization (GO:0002934)5.10534631
3cell adhesion mediated by integrin (GO:0033627)4.97828337
4skin morphogenesis (GO:0043589)4.97301078
5adhesion of symbiont to host cell (GO:0044650)4.78218260
6virion attachment to host cell (GO:0019062)4.78218260
7cellular response to vitamin (GO:0071295)4.62189958
8collagen fibril organization (GO:0030199)4.45998758
9endodermal cell differentiation (GO:0035987)4.44056671
10positive regulation of endothelial cell apoptotic process (GO:2000353)4.41125686
11cellular response to vitamin D (GO:0071305)4.32313133
12angiotensin maturation (GO:0002003)4.06863085
13wound healing, spreading of epidermal cells (GO:0035313)4.05609505
14protein heterotrimerization (GO:0070208)4.05132826
15regulation of vitamin metabolic process (GO:0030656)3.93271249
16epithelial cell-cell adhesion (GO:0090136)3.88391721
17adhesion of symbiont to host (GO:0044406)3.78620001
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.73433452
19wound healing, spreading of cells (GO:0044319)3.51204463
20hemidesmosome assembly (GO:0031581)3.48971727
21peptidyl-proline hydroxylation (GO:0019511)3.42113566
22positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.37050296
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.31986691
24Golgi transport vesicle coating (GO:0048200)3.30869830
25COPI coating of Golgi vesicle (GO:0048205)3.30869830
26positive regulation of p38MAPK cascade (GO:1900745)3.26643359
27cellular response to interferon-alpha (GO:0035457)3.25322700
28sequestering of extracellular ligand from receptor (GO:0035581)3.24036628
29low-density lipoprotein particle clearance (GO:0034383)3.22145892
30regulation of tight junction assembly (GO:2000810)3.22057836
31apoptotic cell clearance (GO:0043277)3.21732823
32negative regulation of chondrocyte differentiation (GO:0032331)3.19147678
33negative regulation of fatty acid transport (GO:2000192)3.18283908
34regulation of vitamin D biosynthetic process (GO:0060556)3.17101382
35regulation of integrin-mediated signaling pathway (GO:2001044)3.10015891
36mesodermal cell differentiation (GO:0048333)3.09074393
37regulation of water loss via skin (GO:0033561)3.08265343
38actin filament depolymerization (GO:0030042)3.07504787
39positive regulation of osteoblast proliferation (GO:0033690)3.07315564
40collagen metabolic process (GO:0032963)3.04744870
41extracellular matrix disassembly (GO:0022617)3.04695529
42neuron projection extension involved in neuron projection guidance (GO:1902284)3.03147228
43axon extension involved in axon guidance (GO:0048846)3.03147228
44renal filtration (GO:0097205)3.02211460
45maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.01221192
46bone trabecula formation (GO:0060346)3.00499141
47multicellular organismal macromolecule metabolic process (GO:0044259)3.00366958
48multicellular organismal catabolic process (GO:0044243)2.99786077
49negative regulation of keratinocyte proliferation (GO:0010839)2.99318189
50regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.95913601
51collagen catabolic process (GO:0030574)2.95799398
52bundle of His cell to Purkinje myocyte communication (GO:0086069)2.94386383
53regulation of mononuclear cell migration (GO:0071675)2.92084592
54eosinophil chemotaxis (GO:0048245)2.89684099
55atrioventricular valve morphogenesis (GO:0003181)2.89509788
56multicellular organismal metabolic process (GO:0044236)2.89306616
57hepatocyte apoptotic process (GO:0097284)2.89230404
58establishment of skin barrier (GO:0061436)2.87942559
59mesenchymal-epithelial cell signaling (GO:0060638)2.86607737
60regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.85618271
61hippo signaling (GO:0035329)2.85290489
62regulation of apoptotic process involved in morphogenesis (GO:1902337)2.85230227
63regulation of transforming growth factor beta2 production (GO:0032909)2.85151151
64negative regulation of smooth muscle cell migration (GO:0014912)2.84838774
65protein retention in ER lumen (GO:0006621)2.84724556
66negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.82836218
67epoxygenase P450 pathway (GO:0019373)2.81538945
68protein hydroxylation (GO:0018126)2.76220297
69positive regulation of epithelial to mesenchymal transition (GO:0010718)2.75542024
70NADH metabolic process (GO:0006734)2.75373826
71germ cell migration (GO:0008354)2.74487546
72renal system process involved in regulation of blood volume (GO:0001977)2.72750680
73regulation of transforming growth factor beta1 production (GO:0032908)2.70030777
74* cellular response to nutrient (GO:0031670)2.69855950
75glomerular filtration (GO:0003094)2.68788221
76vascular endothelial growth factor signaling pathway (GO:0038084)2.68674898
77substrate-dependent cell migration (GO:0006929)2.68027666
78endocardial cushion development (GO:0003197)2.67158603
79keratinocyte proliferation (GO:0043616)2.66590783
80glycosphingolipid catabolic process (GO:0046479)2.64809294
81keratinocyte differentiation (GO:0030216)2.64492640
82chondrocyte development (GO:0002063)2.64307121
83negative regulation of cartilage development (GO:0061037)2.63539957
84basement membrane organization (GO:0071711)2.62130188
85positive regulation of cartilage development (GO:0061036)2.60575213
86regulation of interleukin-8 secretion (GO:2000482)2.59260077
87cell-substrate junction assembly (GO:0007044)2.59000361
88positive regulation of blood vessel endothelial cell migration (GO:0043536)2.56371904
89positive regulation of natural killer cell differentiation (GO:0032825)2.56134465
90positive regulation of extracellular matrix organization (GO:1903055)2.55721830
91endothelial cell morphogenesis (GO:0001886)2.53044334
92stress fiber assembly (GO:0043149)2.52873047
93glycolipid catabolic process (GO:0019377)2.52387176
94regulation of glomerular filtration (GO:0003093)2.52336035
95omega-hydroxylase P450 pathway (GO:0097267)2.51228924
96protein localization to endosome (GO:0036010)2.51092582
97transcytosis (GO:0045056)2.50763790
98eosinophil migration (GO:0072677)2.50286161
99surfactant homeostasis (GO:0043129)2.49972978
100multicellular organismal water homeostasis (GO:0050891)2.49614995
101retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49176237
102regulation of cartilage development (GO:0061035)2.49069644
103plasma membrane repair (GO:0001778)2.48992420
104NIK/NF-kappaB signaling (GO:0038061)2.48102160
105dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.47855771
106response to laminar fluid shear stress (GO:0034616)2.47767041
107tight junction assembly (GO:0070830)2.45670548
108intestinal absorption (GO:0050892)2.45621619
109regulation of monocyte chemotaxis (GO:0090025)2.45361032
110fibril organization (GO:0097435)2.45313457
111cell migration involved in sprouting angiogenesis (GO:0002042)2.44896088
112regulation of collagen metabolic process (GO:0010712)2.44669333
113regulation of membrane protein ectodomain proteolysis (GO:0051043)2.44559825
114barbed-end actin filament capping (GO:0051016)2.44480320
115wound healing (GO:0042060)2.44383964
116positive regulation of pseudopodium assembly (GO:0031274)2.43425123
117glial cell migration (GO:0008347)2.42938905
118positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.42070776
119peptide catabolic process (GO:0043171)2.41785533
120substrate adhesion-dependent cell spreading (GO:0034446)2.40588062
121protein localization to cell surface (GO:0034394)2.40166206
122extracellular matrix organization (GO:0030198)2.39804230
123lipoprotein transport (GO:0042953)2.39095286
124extracellular structure organization (GO:0043062)2.38855491
125phospholipid scrambling (GO:0017121)2.38380609
126membrane budding (GO:0006900)2.38147017
127positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.38024447
128decidualization (GO:0046697)2.37869144
129regulation of cholesterol homeostasis (GO:2000188)2.37412747
130fat-soluble vitamin biosynthetic process (GO:0042362)2.37186363
131negative regulation of interleukin-8 production (GO:0032717)2.36786783
132regulation of natural killer cell differentiation (GO:0032823)2.36626687
133positive regulation of Cdc42 GTPase activity (GO:0043089)2.29463032
134gap junction assembly (GO:0016264)2.26953480
135keratinization (GO:0031424)2.24268947
136membrane raft organization (GO:0031579)2.22883983
137positive regulation of chemokine biosynthetic process (GO:0045080)2.21165298
138intestinal epithelial cell development (GO:0060576)2.20596881
139regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.19330105
140regulation of extracellular matrix disassembly (GO:0010715)2.18548128
141regulation of early endosome to late endosome transport (GO:2000641)2.17552325
142negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.16641138
143fructose metabolic process (GO:0006000)2.15870943
144positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.15298224
145negative regulation of protein localization to plasma membrane (GO:1903077)2.15043405
146intermediate filament organization (GO:0045109)2.14742787
147hypotonic response (GO:0006971)2.14266555
148regulation of pseudopodium assembly (GO:0031272)2.13951774
149regulation of cytokine secretion involved in immune response (GO:0002739)2.13184399
150endocytic recycling (GO:0032456)2.12079979
151membrane lipid catabolic process (GO:0046466)2.11648377
152diacylglycerol metabolic process (GO:0046339)2.11427856
153serine transport (GO:0032329)2.10255931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.86689730
2* TRIM28_21343339_ChIP-Seq_HEK293_Human5.62694736
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.59822215
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.47419214
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.10602152
6* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.89357964
7CLOCK_20551151_ChIP-Seq_293T_Human2.52374701
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.50269992
9SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.37545287
10SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.37545287
11TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.35791515
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.34032950
13RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.27945237
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.20137373
15* SOX2_20726797_ChIP-Seq_SW620_Human2.18527572
16* CJUN_26792858_Chip-Seq_BT549_Human2.17683882
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.13410206
18PPAR_26484153_Chip-Seq_NCI-H1993_Human2.04078129
19HIF1A_21447827_ChIP-Seq_MCF-7_Human1.99728298
20CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.95906289
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.90151386
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84514546
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.81764286
24SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.75728336
25* ATF3_27146783_Chip-Seq_COLON_Human1.74685049
26* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.72801375
27JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71666657
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71095877
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.70440492
30* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.67258429
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.67206805
32* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.66871414
33* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.66871414
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.66380451
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.65016108
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61219026
37BRD4_25478319_ChIP-Seq_HGPS_Human1.60873705
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.57256627
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55576834
40ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.55048648
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.52716832
42JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50577255
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49736959
44RACK7_27058665_Chip-Seq_MCF-7_Human1.49398283
45GATA4_25053715_ChIP-Seq_YYC3_Human1.48970633
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.47294732
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44015550
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40732576
49PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39217136
50UBF1/2_26484160_Chip-Seq_HMECs_Human1.38443430
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.37160009
52KLF5_25053715_ChIP-Seq_YYC3_Human1.36373629
53P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33993307
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.32240642
55TP53_18474530_ChIP-ChIP_U2OS_Human1.31000189
56* GATA2_21666600_ChIP-Seq_HMVEC_Human1.27679930
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.26782351
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26177370
59* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25352928
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24213049
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23154293
62SMC1_22415368_ChIP-Seq_MEFs_Mouse1.22950638
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.22211031
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22158140
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22157114
66GATA6_25053715_ChIP-Seq_YYC3_Human1.21796485
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21549545
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21007491
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19313067
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.18808122
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18391053
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17863445
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17792915
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15223563
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14657045
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14259405
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.13805644
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.13708895
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11926212
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11880229
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.11821493
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08225111
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08207515
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06321070
85ELK1_22589737_ChIP-Seq_MCF10A_Human1.04812916
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04728542
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04126044
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03940825
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03658070
90EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03461409
91TP53_22127205_ChIP-Seq_IMR90_Human1.01288619
92GATA3_24758297_ChIP-Seq_MCF-7_Human1.01007021
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00713765
94* TP53_23651856_ChIP-Seq_MEFs_Mouse1.00674343
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99953462
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98772717
97* TP63_23658742_ChIP-Seq_EP156T_Human0.98690675
98AHR_22903824_ChIP-Seq_MCF-7_Human0.95037453
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94834694
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94695643
101TP53_16413492_ChIP-PET_HCT116_Human0.94472637
102* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93300936
103GATA1_22025678_ChIP-Seq_K562_Human0.92841462
104TCF4_18268006_ChIP-ChIP_LS174T_Human0.91782855
105IRF8_22096565_ChIP-ChIP_GC-B_Human0.88156496
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87112193
107IRF8_27001747_Chip-Seq_BMDM_Mouse0.86792197
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85732722
109ZNF263_19887448_ChIP-Seq_K562_Human0.85069555
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84257691
111TBX20_22328084_ChIP-Seq_HEART_Mouse0.83602370
112TBX20_22080862_ChIP-Seq_HEART_Mouse0.83602370
113LXR_22292898_ChIP-Seq_THP-1_Human0.82876009
114KDM2B_26808549_Chip-Seq_K562_Human0.82640856
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82373964
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82348680
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82307281
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81014317
119HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80407969
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79964890
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77763020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.64636614
2MP0005275_abnormal_skin_tensile5.07722989
3MP0003705_abnormal_hypodermis_morpholog4.57231006
4MP0010234_abnormal_vibrissa_follicle4.45048846
5MP0010352_gastrointestinal_tract_polyps3.30640620
6MP0005623_abnormal_meninges_morphology3.13825002
7MP0005503_abnormal_tendon_morphology2.89057031
8MP0002877_abnormal_melanocyte_morpholog2.85353082
9MP0005360_urolithiasis2.78784821
10MP0009384_cardiac_valve_regurgitation2.58982609
11MP0003279_aneurysm2.56055999
12MP0006054_spinal_hemorrhage2.45687825
13MP0004272_abnormal_basement_membrane2.41481940
14MP0003566_abnormal_cell_adhesion2.40255109
15MP0001958_emphysema2.38916888
16MP0009840_abnormal_foam_cell2.27234775
17MP0002060_abnormal_skin_morphology2.26971063
18MP0002796_impaired_skin_barrier2.17239946
19MP0005409_darkened_coat_color2.13848991
20MP0005023_abnormal_wound_healing2.12328756
21MP0003091_abnormal_cell_migration1.96205186
22MP0003941_abnormal_skin_development1.77367738
23MP0005670_abnormal_white_adipose1.76825591
24MP0005501_abnormal_skin_physiology1.75142754
25MP0003453_abnormal_keratinocyte_physiol1.69063628
26MP0005257_abnormal_intraocular_pressure1.68132211
27MP0003300_gastrointestinal_ulcer1.65185606
28MP0001348_abnormal_lacrimal_gland1.64788997
29MP0005508_abnormal_skeleton_morphology1.62785325
30MP0001542_abnormal_bone_strength1.59650228
31MP0005666_abnormal_adipose_tissue1.58967580
32MP0003045_fibrosis1.58938047
33MP0003950_abnormal_plasma_membrane1.56534779
34MP0002139_abnormal_hepatobiliary_system1.51098946
35MP0003303_peritoneal_inflammation1.50996471
36MP0002295_abnormal_pulmonary_circulatio1.45357667
37MP0003183_abnormal_peptide_metabolism1.42505674
38MP0003191_abnormal_cellular_cholesterol1.42143143
39MP0002896_abnormal_bone_mineralization1.39219187
40MP0005375_adipose_tissue_phenotype1.37924628
41MP0005367_renal/urinary_system_phenotyp1.36481584
42MP0000516_abnormal_urinary_system1.36481584
43MP0002254_reproductive_system_inflammat1.32757183
44MP0001243_abnormal_dermal_layer1.32002763
45MP0003868_abnormal_feces_composition1.31083749
46MP0005451_abnormal_body_composition1.29490420
47MP0005166_decreased_susceptibility_to1.28908587
48MP0009053_abnormal_anal_canal1.28313553
49MP0005076_abnormal_cell_differentiation1.26938367
50MP0004782_abnormal_surfactant_physiolog1.26149207
51MP0004947_skin_inflammation1.24035455
52MP0003385_abnormal_body_wall1.23840873
53MP0000733_abnormal_muscle_development1.23543084
54MP0009780_abnormal_chondrocyte_physiolo1.22098985
55MP0010030_abnormal_orbit_morphology1.21598383
56MP0000858_altered_metastatic_potential1.21570021
57MP0005390_skeleton_phenotype1.19685260
58MP0006082_CNS_inflammation1.18721428
59MP0010678_abnormal_skin_adnexa1.18339061
60MP0010771_integument_phenotype1.17314767
61MP0001533_abnormal_skeleton_physiology1.16980711
62MP0001216_abnormal_epidermal_layer1.16046240
63MP0003283_abnormal_digestive_organ1.15866436
64MP0003724_increased_susceptibility_to1.14175677
65MP0004019_abnormal_vitamin_homeostasis1.10401206
66MP0000003_abnormal_adipose_tissue1.08438913
67MP0002971_abnormal_brown_adipose1.08188096
68MP0009785_altered_susceptibility_to1.07697150
69MP0010368_abnormal_lymphatic_system1.06663112
70MP0005085_abnormal_gallbladder_physiolo1.06660203
71MP0002168_other_aberrant_phenotype1.05768660
72MP0000013_abnormal_adipose_tissue1.02760893
73MP0001299_abnormal_eye_distance/1.02278288
74MP0009250_abnormal_appendicular_skeleto0.99855626
75MP0006138_congestive_heart_failure0.99810238
76MP0001346_abnormal_lacrimal_gland0.98308020
77MP0002098_abnormal_vibrissa_morphology0.97899890
78MP0000462_abnormal_digestive_system0.97172773
79MP0000343_altered_response_to0.95779754
80MP0003075_altered_response_to0.95519691
81MP0005365_abnormal_bile_salt0.95049535
82MP0002998_abnormal_bone_remodeling0.94884719
83MP0002148_abnormal_hypersensitivity_rea0.94516605
84MP0000537_abnormal_urethra_morphology0.94215941
85MP0009643_abnormal_urine_homeostasis0.94035135
86MP0001849_ear_inflammation0.93320874
87MP0000467_abnormal_esophagus_morphology0.93031225
88MP0000163_abnormal_cartilage_morphology0.90491382
89MP0005595_abnormal_vascular_smooth0.89649188
90MP0003448_altered_tumor_morphology0.89346619
91MP0000767_abnormal_smooth_muscle0.86064604
92MP0002282_abnormal_trachea_morphology0.85260520
93MP0003795_abnormal_bone_structure0.84091897
94MP0003828_pulmonary_edema0.83151475
95MP0000377_abnormal_hair_follicle0.82367465
96MP0004858_abnormal_nervous_system0.82013517
97MP0002089_abnormal_postnatal_growth/wei0.81987567
98MP0002933_joint_inflammation0.81862941
99MP0003436_decreased_susceptibility_to0.81848739
100MP0000678_abnormal_parathyroid_gland0.80440532
101MP0000249_abnormal_blood_vessel0.79569801
102MP0001188_hyperpigmentation0.79360980
103MP0002115_abnormal_skeleton_extremities0.79331850
104MP0005084_abnormal_gallbladder_morpholo0.78799732
105MP0010155_abnormal_intestine_physiology0.78178507
106MP0002113_abnormal_skeleton_development0.77128545
107* MP0001191_abnormal_skin_condition0.75496547
108MP0004185_abnormal_adipocyte_glucose0.75026711
109MP0003866_abnormal_defecation0.74340853
110MP0002136_abnormal_kidney_physiology0.73282491
111MP0004134_abnormal_chest_morphology0.73090948
112MP0008260_abnormal_autophagy0.72307070
113MP0009115_abnormal_fat_cell0.71917484
114MP0005164_abnormal_response_to0.71289903
115MP0001666_abnormal_nutrient_absorption0.71111084
116MP0000477_abnormal_intestine_morphology0.70877960
117MP0001664_abnormal_digestion0.70470565
118MP0000762_abnormal_tongue_morphology0.69764089
119MP0009931_abnormal_skin_appearance0.69105902
120* MP0000627_abnormal_mammary_gland0.68972416
121MP0003755_abnormal_palate_morphology0.68562635
122MP0003115_abnormal_respiratory_system0.66982422
123MP0001881_abnormal_mammary_gland0.66064806
124MP0002932_abnormal_joint_morphology0.65061361
125MP0000538_abnormal_urinary_bladder0.64058369
126MP0000685_abnormal_immune_system0.63970187
127MP0003942_abnormal_urinary_system0.63669544
128MP0001879_abnormal_lymphatic_vessel0.62823450
129MP0000428_abnormal_craniofacial_morphol0.62397955
130MP0002166_altered_tumor_susceptibility0.60865182
131MP0000490_abnormal_crypts_of0.59402169
132MP0004264_abnormal_extraembryonic_tissu0.58952717
133MP0002138_abnormal_hepatobiliary_system0.58842691
134MP0008004_abnormal_stomach_pH0.57036863
135MP0005197_abnormal_uvea_morphology0.56854597
136MP0001614_abnormal_blood_vessel0.56759263
137MP0000750_abnormal_muscle_regeneration0.56610823
138MP0000579_abnormal_nail_morphology0.55972766
139MP0005058_abnormal_lysosome_morphology0.55624491
140MP0001873_stomach_inflammation0.55314716
141MP0005165_increased_susceptibility_to0.55088899

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.64104070
2Premature rupture of membranes (HP:0001788)7.12516879
3Atrophic scars (HP:0001075)5.34943162
4Peritonitis (HP:0002586)5.17242593
5Malnutrition (HP:0004395)4.42768204
6Vertebral compression fractures (HP:0002953)4.22728210
7Fragile skin (HP:0001030)4.19881230
8Aortic dissection (HP:0002647)4.08840338
9Shallow orbits (HP:0000586)4.05091344
10Right ventricular cardiomyopathy (HP:0011663)4.03172388
11Cervical subluxation (HP:0003308)3.99155945
12Soft skin (HP:0000977)3.85736217
13Aortic aneurysm (HP:0004942)3.83593653
14Alopecia of scalp (HP:0002293)3.74035184
15Ankle contracture (HP:0006466)3.62951651
16Dilatation of the ascending aorta (HP:0005111)3.51668845
17Neonatal short-limb short stature (HP:0008921)3.51641955
18Abnormality of dentin (HP:0010299)3.48296506
19Abnormality of nail color (HP:0100643)3.44975239
20Cerebral aneurysm (HP:0004944)3.36480286
21Wormian bones (HP:0002645)3.25110368
22Genu recurvatum (HP:0002816)3.15967095
23Plantar hyperkeratosis (HP:0007556)3.14930154
24Blue sclerae (HP:0000592)3.07993720
25Increased IgE level (HP:0003212)2.99534294
26Bladder diverticulum (HP:0000015)2.98623459
27Broad metatarsal (HP:0001783)2.97648141
28Thick nail (HP:0001805)2.92047282
29Hydroxyprolinuria (HP:0003080)2.90009945
30Abnormality of proline metabolism (HP:0010907)2.90009945
31Vascular tortuosity (HP:0004948)2.88515644
32Abnormality of glycolipid metabolism (HP:0010969)2.84734387
33Abnormality of liposaccharide metabolism (HP:0010968)2.84734387
34Abnormality of glycosphingolipid metabolism (HP:0004343)2.84734387
35Palmoplantar hyperkeratosis (HP:0000972)2.68599567
36Mitral valve prolapse (HP:0001634)2.59717611
37Arterial tortuosity (HP:0005116)2.58638579
38Biconcave vertebral bodies (HP:0004586)2.57580158
39Spinal rigidity (HP:0003306)2.55722824
40Abnormal delivery (HP:0001787)2.54937007
41Thin bony cortex (HP:0002753)2.54048044
42Increased connective tissue (HP:0009025)2.52202594
43Short nail (HP:0001799)2.49506618
44Abnormality of the acetabulum (HP:0003170)2.48170121
45Hyperextensible skin (HP:0000974)2.46306861
46Palmar hyperkeratosis (HP:0010765)2.44006316
47Aneurysm (HP:0002617)2.43654345
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.42298230
49Osteolytic defects of the hand bones (HP:0009699)2.42298230
50Onycholysis (HP:0001806)2.38782648
51Flat acetabular roof (HP:0003180)2.37552735
52Nail dystrophy (HP:0008404)2.36432119
53Wrist flexion contracture (HP:0001239)2.35554606
54Axonal loss (HP:0003447)2.35432601
55* Hyperparathyroidism (HP:0000843)2.35092125
56Mildly elevated creatine phosphokinase (HP:0008180)2.27144216
57Breech presentation (HP:0001623)2.27107206
58Upper limb amyotrophy (HP:0009129)2.25986054
59Distal upper limb amyotrophy (HP:0007149)2.25986054
60Overgrowth (HP:0001548)2.21930147
61Tibial bowing (HP:0002982)2.20353732
62Follicular hyperkeratosis (HP:0007502)2.16321751
63Bowel diverticulosis (HP:0005222)2.14905225
64Elbow flexion contracture (HP:0002987)2.14304300
65Tetraparesis (HP:0002273)2.13393459
66Coxa vara (HP:0002812)2.11633312
67Dysostosis multiplex (HP:0000943)2.11565499
68Hemorrhage of the eye (HP:0011885)2.11082857
69Ileus (HP:0002595)2.09410617
70Hand muscle atrophy (HP:0009130)2.09256537
71Abdominal distention (HP:0003270)2.08465713
72Deviation of the hallux (HP:0010051)2.07855088
73Abnormality of the peritoneum (HP:0002585)2.04877632
74Ectopia lentis (HP:0001083)2.04587168
75Acanthosis nigricans (HP:0000956)2.04252106
76Pili torti (HP:0003777)2.03608428
77Congenital glaucoma (HP:0001087)2.03593231
78Urinary glycosaminoglycan excretion (HP:0003541)2.00981142
79Mucopolysacchariduria (HP:0008155)2.00981142
80Systemic lupus erythematosus (HP:0002725)2.00741305
81Abnormality of polysaccharide metabolism (HP:0011012)2.00705652
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00705652
83Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00705652
84Abnormality of the distal phalanges of the toes (HP:0010182)2.00106814
85Type 1 muscle fiber predominance (HP:0003803)1.99894397
86Ulnar bowing (HP:0003031)1.98610144
87Spondylolisthesis (HP:0003302)1.97694222
88Abnormal blistering of the skin (HP:0008066)1.97554588
89Radial bowing (HP:0002986)1.96771999
90Cupped ribs (HP:0000887)1.96718558
91Hallux valgus (HP:0001822)1.96458203
92Abnormality of carpal bone ossification (HP:0006257)1.96190643
93Mitral stenosis (HP:0001718)1.94357969
94Cardiovascular calcification (HP:0011915)1.93655927
95Natal tooth (HP:0000695)1.92309217
96Coronal craniosynostosis (HP:0004440)1.92147670
97Corneal erosion (HP:0200020)1.91846005
98Spinal cord compression (HP:0002176)1.91829764
99Chronic diarrhea (HP:0002028)1.91494229
100Camptodactyly of toe (HP:0001836)1.89953144
101Buphthalmos (HP:0000557)1.88818507
102Neurofibrillary tangles (HP:0002185)1.88551452
103Pterygium (HP:0001059)1.87071441
104Femoral bowing (HP:0002980)1.86879322
105Infantile muscular hypotonia (HP:0008947)1.85486356
106Hypotrichosis (HP:0001006)1.85094164
107Mitral regurgitation (HP:0001653)1.84677384
108Milia (HP:0001056)1.83523804
109Subacute progressive viral hepatitis (HP:0006572)1.82638936
110Wide anterior fontanel (HP:0000260)1.82568703
111Micronodular cirrhosis (HP:0001413)1.82107319
112Fat malabsorption (HP:0002630)1.80980228
113Vertebral hypoplasia (HP:0008417)1.80516116
114Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.80516116
115Distal lower limb amyotrophy (HP:0008944)1.80246550
116Joint laxity (HP:0001388)1.79781223
117Bowing of the arm (HP:0006488)1.79394469
118Bowed forearm bones (HP:0003956)1.79394469
119Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79255583
120Beaking of vertebral bodies (HP:0004568)1.78484572
121Abnormality of glutamine family amino acid metabolism (HP:0010902)1.78181805
122Nonimmune hydrops fetalis (HP:0001790)1.77969754
123Abnormality of the 2nd finger (HP:0004100)1.76371749
124Hoarse voice (HP:0001609)1.75316178
125Broad ribs (HP:0000885)1.75054829
126Woolly hair (HP:0002224)1.74603188
127Abnormal hair laboratory examination (HP:0003328)1.74484837
128Aortic regurgitation (HP:0001659)1.73595446
129Abnormality of the costochondral junction (HP:0000919)1.73582321
130Abnormality of the anterior chamber (HP:0000593)1.73164579
131Ovoid vertebral bodies (HP:0003300)1.72316424
132Vacuolated lymphocytes (HP:0001922)1.72142366
133Renal tubular acidosis (HP:0001947)1.71806719
134Protuberant abdomen (HP:0001538)1.71478752
135Corneal dystrophy (HP:0001131)1.71096907
136Increased density of long bones (HP:0006392)1.71041084
137Interstitial pulmonary disease (HP:0006530)1.70225811
138Fragile nails (HP:0001808)1.69573904
139Trismus (HP:0000211)1.68819932
140Bone pain (HP:0002653)1.68732316
141Osteopenia (HP:0000938)1.68578839
142Congenital ichthyosiform erythroderma (HP:0007431)1.68314102
143Abnormal ossification of hand bones (HP:0005921)1.68301177
144Platyspondyly (HP:0000926)1.67210690
145Emphysema (HP:0002097)1.67199958
146Tarsal synostosis (HP:0008368)1.66017011
147Hyperactive renin-angiotensin system (HP:0000841)1.65627553
148Abnormality of monocarboxylic acid metabolism (HP:0010996)1.65045314
149Nausea (HP:0002018)1.63254655
150Curly hair (HP:0002212)1.62979167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.91025499
2FRK3.29631160
3DDR23.08858333
4ERN13.01762404
5PIM22.89433686
6TESK12.84914156
7IRAK32.73231555
8TRIB32.70828096
9EPHB22.67010743
10MST42.50125236
11PDGFRA2.28692419
12FER2.24309239
13TTN2.15000544
14STK242.13935303
15LATS12.06761350
16ACVR1B2.06559753
17PTK62.05439656
18PTK21.98999778
19MST1R1.82944819
20EPHA31.77503752
21LRRK21.77476043
22LIMK11.75775738
23PAK31.74884177
24TRPM71.74331675
25LATS21.64240449
26PAK41.59057979
27RIPK11.53871600
28NEK91.51991492
29PKN21.51605982
30MET1.49257341
31EPHB11.46697282
32MAP3K121.34910248
33PAK21.34376039
34DYRK1B1.31654316
35BMX1.30736375
36MAPKAPK31.27082747
37SCYL21.24812460
38RPS6KA41.21700258
39STK101.21044240
40MAP3K31.14533291
41ERBB31.13184161
42MAP3K141.12333295
43MOS1.09821038
44MAP2K11.08424116
45CDC42BPA1.07042587
46STK38L1.06728630
47SIK11.04870307
48TBK11.03947679
49PRKG21.03214376
50PIK3CA1.00714129
51NME20.99645595
52ICK0.99133009
53MAP3K20.98189780
54MAP2K20.96583109
55CHUK0.94536127
56STK30.93542376
57PRPF4B0.93395816
58IKBKB0.93339718
59DAPK30.92232392
60PBK0.90240731
61RPS6KB20.88503319
62MATK0.88186188
63TAOK20.87543308
64GRK70.86474461
65CDK60.83907379
66ROCK10.81963893
67PDK20.80063617
68NUAK10.79537455
69MAP3K60.78175152
70MYLK0.77044359
71JAK30.76771221
72MAP3K10.76644527
73AKT30.76500490
74TESK20.75077732
75BMPR20.72916443
76EEF2K0.71764182
77NTRK10.71469353
78FLT30.70028796
79RPS6KA20.68606035
80PDGFRB0.68053084
81PDPK10.67941645
82FGFR40.66122504
83JAK10.65706806
84TGFBR20.63707481
85PIK3CG0.62944991
86MAP3K80.61512989
87MAPKAPK20.61147353
88DMPK0.60521279
89FGFR10.59401354
90ILK0.59072229
91MELK0.56901471
92STK390.56881165
93TGFBR10.56673565
94MAPK70.56110585
95TAOK10.55721308
96PRKAA20.54835381
97PTK2B0.54400888
98ERBB40.52732280
99MAP3K110.52719138
100MAP3K100.52498553
101LMTK20.51598166
102CDK120.51064940
103ZAP700.50594740
104INSR0.50273426
105ABL20.50130375
106MTOR0.49722794
107PAK10.48644260
108STK380.48122668
109TYK20.47398849
110ARAF0.47293063
111CAMK2G0.44458227
112PRKCI0.44288365
113KDR0.43837310
114FGFR30.42358323
115ROCK20.40955843
116SRC0.40534858
117PRKD10.37939498
118SIK30.36878425
119IKBKE0.36695465
120GSK3A0.35341856
121CSK0.35126055
122CAMK2D0.35120244
123ABL10.34261633
124PRKCE0.33358843
125MAP3K50.33154049
126BCR0.32606037
127PIM10.32372954
128MAP3K130.31799205
129KSR20.29935882
130EGFR0.29783070
131RET0.25746279
132IGF1R0.25323090
133PRKD20.24463705

Predicted pathways (KEGG)

RankGene SetZ-score
1Bladder cancer_Homo sapiens_hsa052192.99051585
2ECM-receptor interaction_Homo sapiens_hsa045122.98480885
3p53 signaling pathway_Homo sapiens_hsa041152.29994174
4Focal adhesion_Homo sapiens_hsa045102.23389708
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.17548246
6Proteoglycans in cancer_Homo sapiens_hsa052052.07033327
7Adherens junction_Homo sapiens_hsa045202.06321798
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.06258261
9PPAR signaling pathway_Homo sapiens_hsa033202.00653790
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.87585565
11Leukocyte transendothelial migration_Homo sapiens_hsa046701.80319442
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.76716279
13Amoebiasis_Homo sapiens_hsa051461.76012234
14Protein digestion and absorption_Homo sapiens_hsa049741.73596440
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.73216205
16* Small cell lung cancer_Homo sapiens_hsa052221.72205787
17TNF signaling pathway_Homo sapiens_hsa046681.71225255
18Malaria_Homo sapiens_hsa051441.66441873
19MicroRNAs in cancer_Homo sapiens_hsa052061.64634138
20Renin-angiotensin system_Homo sapiens_hsa046141.63969262
21Mineral absorption_Homo sapiens_hsa049781.59992938
22Chronic myeloid leukemia_Homo sapiens_hsa052201.58556978
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.57046720
24Fat digestion and absorption_Homo sapiens_hsa049751.55275667
25Shigellosis_Homo sapiens_hsa051311.50201191
26Hippo signaling pathway_Homo sapiens_hsa043901.49992873
27Tight junction_Homo sapiens_hsa045301.47262981
28Melanoma_Homo sapiens_hsa052181.42977001
29Apoptosis_Homo sapiens_hsa042101.40953894
30Toxoplasmosis_Homo sapiens_hsa051451.40452902
31Fructose and mannose metabolism_Homo sapiens_hsa000511.32544950
32Pancreatic cancer_Homo sapiens_hsa052121.22743339
33* TGF-beta signaling pathway_Homo sapiens_hsa043501.20873230
34Histidine metabolism_Homo sapiens_hsa003401.20645602
35Leishmaniasis_Homo sapiens_hsa051401.18222761
36Starch and sucrose metabolism_Homo sapiens_hsa005001.17135655
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16609826
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16114993
39Sulfur metabolism_Homo sapiens_hsa009201.15102026
40Salmonella infection_Homo sapiens_hsa051321.13952490
41Glycerolipid metabolism_Homo sapiens_hsa005611.10627279
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10445825
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08167225
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07683385
45Phagosome_Homo sapiens_hsa041451.05720265
46Glioma_Homo sapiens_hsa052141.03917856
47Viral myocarditis_Homo sapiens_hsa054161.03526759
48PI3K-Akt signaling pathway_Homo sapiens_hsa041511.02921380
49Lysosome_Homo sapiens_hsa041420.99450704
50Bile secretion_Homo sapiens_hsa049760.97342547
51Vibrio cholerae infection_Homo sapiens_hsa051100.95908782
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95462745
53Prion diseases_Homo sapiens_hsa050200.95433681
54Sphingolipid metabolism_Homo sapiens_hsa006000.93268905
55Legionellosis_Homo sapiens_hsa051340.93144404
56Pertussis_Homo sapiens_hsa051330.91530884
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.91380846
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87743418
59Prostate cancer_Homo sapiens_hsa052150.85540505
60Arachidonic acid metabolism_Homo sapiens_hsa005900.85184387
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83572067
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.83185680
63Rheumatoid arthritis_Homo sapiens_hsa053230.82810706
64* Pathways in cancer_Homo sapiens_hsa052000.82046097
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81960425
66African trypanosomiasis_Homo sapiens_hsa051430.81688938
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81046723
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80847631
69Tuberculosis_Homo sapiens_hsa051520.80564194
70Basal cell carcinoma_Homo sapiens_hsa052170.80454914
71Thyroid cancer_Homo sapiens_hsa052160.79970366
72* Viral carcinogenesis_Homo sapiens_hsa052030.79770345
73Dilated cardiomyopathy_Homo sapiens_hsa054140.78302379
74VEGF signaling pathway_Homo sapiens_hsa043700.77875135
75Osteoclast differentiation_Homo sapiens_hsa043800.77741748
76Dorso-ventral axis formation_Homo sapiens_hsa043200.77101045
77Insulin resistance_Homo sapiens_hsa049310.77065321
78Hepatitis C_Homo sapiens_hsa051600.76775184
79HIF-1 signaling pathway_Homo sapiens_hsa040660.76169029
80Rap1 signaling pathway_Homo sapiens_hsa040150.75813251
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75437258
82Phenylalanine metabolism_Homo sapiens_hsa003600.74368019
83Retinol metabolism_Homo sapiens_hsa008300.74185899
84Galactose metabolism_Homo sapiens_hsa000520.72273599
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72256570
86Caffeine metabolism_Homo sapiens_hsa002320.71728743
87Platelet activation_Homo sapiens_hsa046110.71502089
88Hepatitis B_Homo sapiens_hsa051610.71259472
89Hedgehog signaling pathway_Homo sapiens_hsa043400.69087274
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67719760
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67476091
92Endocytosis_Homo sapiens_hsa041440.66252186
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65902510
94Glutathione metabolism_Homo sapiens_hsa004800.65877185
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65072083
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64539553
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63862677
98Fatty acid biosynthesis_Homo sapiens_hsa000610.63361791
99Vitamin digestion and absorption_Homo sapiens_hsa049770.63028160
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62417635
101Endometrial cancer_Homo sapiens_hsa052130.62236520
102Chemical carcinogenesis_Homo sapiens_hsa052040.61903751
103* HTLV-I infection_Homo sapiens_hsa051660.60333413
104Fatty acid degradation_Homo sapiens_hsa000710.59826057
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59243549
106Other glycan degradation_Homo sapiens_hsa005110.59167604
107Acute myeloid leukemia_Homo sapiens_hsa052210.58073101
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.57729823
109AMPK signaling pathway_Homo sapiens_hsa041520.57515362
110Prolactin signaling pathway_Homo sapiens_hsa049170.56993582
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56966154
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56753364
113Pancreatic secretion_Homo sapiens_hsa049720.56724509
114Renin secretion_Homo sapiens_hsa049240.55931575
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54479039
116Arginine biosynthesis_Homo sapiens_hsa002200.54375001
117Linoleic acid metabolism_Homo sapiens_hsa005910.53759676
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52062002
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51924310
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51877428
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.51624587
122Antigen processing and presentation_Homo sapiens_hsa046120.51059338
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.50069583
124Non-small cell lung cancer_Homo sapiens_hsa052230.49068585
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.48229702
126Notch signaling pathway_Homo sapiens_hsa043300.47669628
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.47511274
128Insulin signaling pathway_Homo sapiens_hsa049100.47340773
129Ras signaling pathway_Homo sapiens_hsa040140.47151020
130GnRH signaling pathway_Homo sapiens_hsa049120.46760515
131Hematopoietic cell lineage_Homo sapiens_hsa046400.46248429
132Complement and coagulation cascades_Homo sapiens_hsa046100.46170174
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.45899116
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44890600
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.44492167
136Measles_Homo sapiens_hsa051620.44384600
137Arginine and proline metabolism_Homo sapiens_hsa003300.43580459
138Influenza A_Homo sapiens_hsa051640.43160735
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.41919108

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