CDKN2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)5.62239488
2negative regulation of phagocytosis (GO:0050765)4.90877339
3regulation of mitotic spindle organization (GO:0060236)4.74288622
4regulation of sequestering of triglyceride (GO:0010889)4.68309310
5fusion of sperm to egg plasma membrane (GO:0007342)4.65512554
6ribosomal small subunit biogenesis (GO:0042274)4.62466413
7positive regulation of histone deacetylation (GO:0031065)4.43748459
8triglyceride catabolic process (GO:0019433)4.40336644
9white fat cell differentiation (GO:0050872)4.31627417
10acrosome assembly (GO:0001675)4.27324086
11DNA strand elongation involved in DNA replication (GO:0006271)4.22843072
12DNA strand elongation (GO:0022616)4.21755104
13brown fat cell differentiation (GO:0050873)4.12557940
14protein heterotrimerization (GO:0070208)4.10313199
15valine metabolic process (GO:0006573)4.07007173
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.01899987
17regulation of cholesterol storage (GO:0010885)4.01128998
18regulation of spindle organization (GO:0090224)3.95578599
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.92220757
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.92220757
21nuclear pore complex assembly (GO:0051292)3.90584026
22DNA topological change (GO:0006265)3.83258106
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.81880009
24Golgi transport vesicle coating (GO:0048200)3.78102464
25COPI coating of Golgi vesicle (GO:0048205)3.78102464
26DNA replication initiation (GO:0006270)3.76369260
27protein maturation by protein folding (GO:0022417)3.74303667
28nucleobase-containing small molecule interconversion (GO:0015949)3.73929816
29mitotic metaphase plate congression (GO:0007080)3.73020347
30acylglycerol catabolic process (GO:0046464)3.72437047
31neutral lipid catabolic process (GO:0046461)3.72437047
32translesion synthesis (GO:0019985)3.66420692
33folic acid metabolic process (GO:0046655)3.58555017
34protoporphyrinogen IX metabolic process (GO:0046501)3.57667755
35cilium or flagellum-dependent cell motility (GO:0001539)3.56617850
36protein localization to chromosome, centromeric region (GO:0071459)3.56592222
37pentose-phosphate shunt (GO:0006098)3.52322018
38proline biosynthetic process (GO:0006561)3.51857710
39sister chromatid segregation (GO:0000819)3.49253289
40positive regulation of protein deacetylation (GO:0090312)3.47854136
41sperm-egg recognition (GO:0035036)3.46026656
42antigen processing and presentation of endogenous antigen (GO:0019883)3.41171829
43negative regulation of granulocyte differentiation (GO:0030853)3.34421553
44maturation of SSU-rRNA (GO:0030490)3.32219366
45negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.32074558
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.31699517
47nuclear pore organization (GO:0006999)3.30057141
48regulation of translational fidelity (GO:0006450)3.28760301
49viral transcription (GO:0019083)3.28581138
50chromosome condensation (GO:0030261)3.27723418
51cell-cell recognition (GO:0009988)3.21494504
52deoxyribonucleotide biosynthetic process (GO:0009263)3.20912984
53regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20411147
54NADPH regeneration (GO:0006740)3.19479957
55mitotic sister chromatid segregation (GO:0000070)3.19441629
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19326400
57mitotic chromosome condensation (GO:0007076)3.17557378
58cellular response to lithium ion (GO:0071285)3.17187453
59mitotic nuclear envelope disassembly (GO:0007077)3.15639246
60binding of sperm to zona pellucida (GO:0007339)3.15626737
61multicellular organism reproduction (GO:0032504)3.15164703
62regulation of mammary gland epithelial cell proliferation (GO:0033599)3.14477205
63lipid particle organization (GO:0034389)3.13760422
64sperm motility (GO:0030317)3.13311358
65formation of translation preinitiation complex (GO:0001731)3.10723642
66plasma membrane fusion (GO:0045026)3.09585779
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.09257024
68translational termination (GO:0006415)3.06544066
69UV protection (GO:0009650)3.05196082
70positive regulation of chromosome segregation (GO:0051984)3.04886264
71antigen processing and presentation via MHC class Ib (GO:0002475)3.02888262
72kinetochore organization (GO:0051383)3.02357217
73NADH metabolic process (GO:0006734)3.00782057
74deoxyribose phosphate biosynthetic process (GO:0046385)3.00416600
752-deoxyribonucleotide biosynthetic process (GO:0009265)3.00416600
76nuclear envelope disassembly (GO:0051081)2.98628943
77membrane disassembly (GO:0030397)2.98628943
78protein localization to kinetochore (GO:0034501)2.98304007
79positive regulation of fatty acid oxidation (GO:0046321)2.97279176
80regulation of fatty acid beta-oxidation (GO:0031998)2.96866167
81metaphase plate congression (GO:0051310)2.93929372
82telomere maintenance via recombination (GO:0000722)2.93799637
83negative regulation of erythrocyte differentiation (GO:0045647)2.93696008
84positive regulation of DNA-dependent DNA replication (GO:2000105)2.91890227
85mitotic recombination (GO:0006312)2.89704994
86chromosome segregation (GO:0007059)2.89474454
87cellular protein complex localization (GO:0034629)2.89232962
88fatty acid homeostasis (GO:0055089)2.88808769
89pore complex assembly (GO:0046931)2.88406272
90protoporphyrinogen IX biosynthetic process (GO:0006782)2.87639245
91establishment of chromosome localization (GO:0051303)2.87566320
92gonadal mesoderm development (GO:0007506)2.86168524
93carnitine transmembrane transport (GO:1902603)2.83905831
94DNA packaging (GO:0006323)2.81008989
95nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80287980
96regulation of fatty acid oxidation (GO:0046320)2.79955257
97reproduction (GO:0000003)2.77202335
98ribonucleoprotein complex biogenesis (GO:0022613)2.76595793
99SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.76207541
100negative regulation of lipid storage (GO:0010888)2.75593384
101protein localization to chromosome (GO:0034502)2.75485858
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.75319005
103spliceosomal tri-snRNP complex assembly (GO:0000244)2.75170285
104DNA replication checkpoint (GO:0000076)2.74322584
105translational elongation (GO:0006414)2.72285732
106protein targeting to ER (GO:0045047)2.70732441
107cotranslational protein targeting to membrane (GO:0006613)2.70285979
108cell wall macromolecule catabolic process (GO:0016998)2.69264075
109cell wall macromolecule metabolic process (GO:0044036)2.69264075
110DNA conformation change (GO:0071103)2.69116408
111DNA synthesis involved in DNA repair (GO:0000731)2.67757705
112microtubule depolymerization (GO:0007019)2.67446805
113protein retention in ER lumen (GO:0006621)2.66693413
114triglyceride biosynthetic process (GO:0019432)2.65334466
115regulation of glucose import in response to insulin stimulus (GO:2001273)2.65142991
116mitotic sister chromatid cohesion (GO:0007064)2.64943242
117cellular protein complex disassembly (GO:0043624)2.64379804
118maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.64273347
119establishment of mitotic spindle localization (GO:0040001)2.64173065
120amino-acid betaine transport (GO:0015838)2.64016682
121carnitine transport (GO:0015879)2.64016682
122viral life cycle (GO:0019058)2.61204912
123glucocorticoid receptor signaling pathway (GO:0042921)2.61166933
124nuclear envelope organization (GO:0006998)2.61030978
125mitotic nuclear envelope reassembly (GO:0007084)2.60761598
126nuclear envelope reassembly (GO:0031468)2.60761598
127meiotic chromosome segregation (GO:0045132)2.59026403
128establishment of protein localization to endoplasmic reticulum (GO:0072599)2.58795492
129regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.57229591
130lipid storage (GO:0019915)2.57166747
131protein complex localization (GO:0031503)2.56865276
132iron ion import (GO:0097286)2.56752628
133negative regulation of necroptotic process (GO:0060546)2.55808378
134regulation of chromosome segregation (GO:0051983)2.54845546
135glucose catabolic process (GO:0006007)2.54755342
136protein localization to endoplasmic reticulum (GO:0070972)2.54281241
137ribosomal large subunit biogenesis (GO:0042273)2.53273769
138regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.52355765
139regulation of necroptotic process (GO:0060544)2.51099773
140regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.50408093
141acylglycerol biosynthetic process (GO:0046463)2.50258054
142neutral lipid biosynthetic process (GO:0046460)2.50258054
143negative regulation of smooth muscle cell migration (GO:0014912)2.50028085
144synaptonemal complex organization (GO:0070193)2.49432540
145positive regulation of cellular response to insulin stimulus (GO:1900078)2.48967264
146translational initiation (GO:0006413)2.48536786
147growth hormone receptor signaling pathway (GO:0060396)2.48251870
148fatty acid transmembrane transport (GO:1902001)2.48037315
149folic acid-containing compound biosynthetic process (GO:0009396)2.47842630
150protein complex disassembly (GO:0043241)2.47718607
151cellular hyperosmotic response (GO:0071474)2.46707140
152regulation of translational termination (GO:0006449)2.46461799
153synaptonemal complex assembly (GO:0007130)2.46021853
154regulation of early endosome to late endosome transport (GO:2000641)2.45385689
155cellular response to zinc ion (GO:0071294)2.44407500
156adaptation of signaling pathway (GO:0023058)2.44227995
157DNA unwinding involved in DNA replication (GO:0006268)2.43867712
158DNA duplex unwinding (GO:0032508)2.43600871
159axonemal dynein complex assembly (GO:0070286)2.43112433
160positive regulation of gamma-delta T cell activation (GO:0046645)2.43026088
161regulation of histone H3-K27 methylation (GO:0061085)2.42979668
162nucleotide-excision repair, DNA gap filling (GO:0006297)2.42928628
163apoptotic process involved in morphogenesis (GO:0060561)2.40822714
164mitochondrial fusion (GO:0008053)2.40819138
165positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.39432170
166pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.39279011
167positive regulation of natural killer cell differentiation (GO:0032825)2.39240485
168motile cilium assembly (GO:0044458)2.36905008
169spermatid development (GO:0007286)2.34765674
170positive regulation of cholesterol efflux (GO:0010875)2.34574000
171biotin metabolic process (GO:0006768)2.34164968
172regulation of macrophage derived foam cell differentiation (GO:0010743)2.33492593
173acrosome reaction (GO:0007340)2.31428418
174carnitine shuttle (GO:0006853)2.30234309
175chromatin assembly (GO:0031497)2.30216532
176cellular response to vitamin (GO:0071295)2.30050856
177alpha-linolenic acid metabolic process (GO:0036109)2.29314165
178definitive hemopoiesis (GO:0060216)2.28718464
179telomere maintenance via semi-conservative replication (GO:0032201)2.28399838
180fatty acid beta-oxidation (GO:0006635)2.26482354
181tricarboxylic acid metabolic process (GO:0072350)2.26131495
182positive regulation of sterol transport (GO:0032373)2.23979799
183positive regulation of cholesterol transport (GO:0032376)2.23979799
184glycerolipid catabolic process (GO:0046503)2.23294294
185response to UV-C (GO:0010225)2.22273676

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.75399736
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.70634908
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.48284929
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.11014910
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.11689706
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.99556894
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.93296984
8* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61024714
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55667685
10* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.49547078
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41952996
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.31804462
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29357186
14VDR_21846776_ChIP-Seq_THP-1_Human2.28422373
15XRN2_22483619_ChIP-Seq_HELA_Human2.24211836
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11895326
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08518634
18MYC_22102868_ChIP-Seq_BL_Human2.07953252
19SCL_19346495_ChIP-Seq_HPC-7_Human2.06514041
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.05663127
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04052932
22* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95599144
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90515390
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87145779
25CLOCK_20551151_ChIP-Seq_293T_Human1.81659905
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78879311
27CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.78329723
28ZFX_18555785_ChIP-Seq_MESCs_Mouse1.78218053
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77727185
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77363935
31AR_21909140_ChIP-Seq_LNCAP_Human1.77243439
32* VDR_24763502_ChIP-Seq_THP-1_Human1.75983408
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74225124
34* DCP1A_22483619_ChIP-Seq_HELA_Human1.73160104
35* MAF_26560356_Chip-Seq_TH1_Human1.71694940
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70545701
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68299753
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66624126
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65184172
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.64694388
41CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.63837808
42* MYB_26560356_Chip-Seq_TH2_Human1.63806243
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62994424
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56765869
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.56493923
46* UTX_26944678_Chip-Seq_JUKART_Human1.56274920
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.54142487
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53861956
49* TTF2_22483619_ChIP-Seq_HELA_Human1.53438554
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53159445
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.52866114
52* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51661470
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.51215340
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48353303
55* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48333452
56* TCF7_22412390_ChIP-Seq_EML_Mouse1.48028590
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47018853
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44518521
59GATA1_22025678_ChIP-Seq_K562_Human1.44278517
60* MYB_26560356_Chip-Seq_TH1_Human1.42350339
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.42285636
62* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40773169
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40048422
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.39689285
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38620098
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37768187
67CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.37454414
68KDM5A_27292631_Chip-Seq_BREAST_Human1.37099919
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37088932
70LXR_22292898_ChIP-Seq_THP-1_Human1.36347133
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34830572
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34765738
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31536169
74* TFEB_21752829_ChIP-Seq_HELA_Human1.31456672
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28423429
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27820144
77* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27699800
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27628603
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27562259
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27020935
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.26958695
82* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26379984
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.23922471
84* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22711464
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22263931
86GABP_19822575_ChIP-Seq_HepG2_Human1.22260718
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21888807
88* RACK7_27058665_Chip-Seq_MCF-7_Human1.21482127
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21219561
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20646052
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19062368
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18431736
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18295071
94SPI1_23547873_ChIP-Seq_NB4_Human1.18017665
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17917528
96ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17365937
97* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13471152
98FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13389713
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11928330
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11866183
101* MAF_26560356_Chip-Seq_TH2_Human1.10909941
102* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10670474
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09459210
104* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08676819
105PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08270811
106GATA1_19941826_ChIP-Seq_K562_Human1.07645201
107CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06178421
108STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06030373
109* KDM2B_26808549_Chip-Seq_DND41_Human1.05051070
110ZNF263_19887448_ChIP-Seq_K562_Human1.04254642
111ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04045520
112* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03012415
113TET1_21451524_ChIP-Seq_MESCs_Mouse1.02320258
114NCOR1_26117541_ChIP-Seq_K562_Human1.02048457
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00962845
116RUNX_20019798_ChIP-Seq_JUKART_Human1.00193920
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99843487
118* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98972982
119TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97967275
120* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.97901856
121* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97300731
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97289968
123P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97259924
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97131636
125SPI1_23127762_ChIP-Seq_K562_Human0.96948845
126CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96630397
127TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96541980
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96140183
129* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95146821
130EST1_17652178_ChIP-ChIP_JURKAT_Human0.94982822
131FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94405142
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93599276
133PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93285876
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92579424
135* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92333817
136GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90878246
137ELF1_20517297_ChIP-Seq_JURKAT_Human0.89954047
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89933037
139ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89709133
140PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89473629
141SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88377377
142GATA3_27048872_Chip-Seq_THYMUS_Human0.87997374
143* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.87731574
144FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87440737
145PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86991525
146VDR_24787735_ChIP-Seq_THP-1_Human0.85815608
147KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85658344
148CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85140831
149PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85048931
150CIITA_25753668_ChIP-Seq_RAJI_Human0.84160120
151HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83266988
152TBX20_22328084_ChIP-Seq_HEART_Mouse0.82727986
153TBX20_22080862_ChIP-Seq_HEART_Mouse0.82727986

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.70639241
2MP0005670_abnormal_white_adipose4.07112073
3MP0005666_abnormal_adipose_tissue3.08710497
4MP0003705_abnormal_hypodermis_morpholog2.96241790
5MP0004185_abnormal_adipocyte_glucose2.92482161
6MP0003693_abnormal_embryo_hatching2.81486555
7MP0005410_abnormal_fertilization2.64198749
8MP0005275_abnormal_skin_tensile2.57783216
9MP0004130_abnormal_muscle_cell2.56335227
10MP0002877_abnormal_melanocyte_morpholog2.41764392
11MP0005375_adipose_tissue_phenotype2.35333510
12MP0004957_abnormal_blastocyst_morpholog2.30890851
13MP0002166_altered_tumor_susceptibility2.15157760
14MP0005076_abnormal_cell_differentiation2.04045975
15MP0008932_abnormal_embryonic_tissue1.96053428
16MP0003300_gastrointestinal_ulcer1.88649026
17MP0000685_abnormal_immune_system1.86833971
18MP0000003_abnormal_adipose_tissue1.86401789
19MP0009115_abnormal_fat_cell1.81974321
20MP0000350_abnormal_cell_proliferation1.81228053
21MP0005397_hematopoietic_system_phenotyp1.76150820
22MP0001545_abnormal_hematopoietic_system1.76150820
23MP0008057_abnormal_DNA_replication1.72412934
24MP0002971_abnormal_brown_adipose1.70513694
25MP0006054_spinal_hemorrhage1.69965442
26MP0002060_abnormal_skin_morphology1.67354158
27MP0003724_increased_susceptibility_to1.64482035
28MP0000013_abnormal_adipose_tissue1.63474204
29MP0002970_abnormal_white_adipose1.59950445
30MP0001730_embryonic_growth_arrest1.52398195
31MP0009379_abnormal_foot_pigmentation1.51910298
32MP0003656_abnormal_erythrocyte_physiolo1.51503560
33MP0009278_abnormal_bone_marrow1.48550656
34MP0001835_abnormal_antigen_presentation1.47653771
35MP0002006_tumorigenesis1.46206014
36MP0005451_abnormal_body_composition1.42551681
37MP0000759_abnormal_skeletal_muscle1.41270683
38MP0000747_muscle_weakness1.38575119
39MP0004233_abnormal_muscle_weight1.38502765
40MP0005334_abnormal_fat_pad1.36550321
41MP0001661_extended_life_span1.35142579
42MP0008058_abnormal_DNA_repair1.34698788
43MP0004808_abnormal_hematopoietic_stem1.31992465
44* MP0010307_abnormal_tumor_latency1.27852364
45MP0003191_abnormal_cellular_cholesterol1.24419261
46MP0003786_premature_aging1.23010664
47MP0003436_decreased_susceptibility_to1.22620150
48MP0010352_gastrointestinal_tract_polyps1.22508896
49MP0003045_fibrosis1.21559164
50* MP0002080_prenatal_lethality1.19847594
51MP0003111_abnormal_nucleus_morphology1.18366241
52MP0006036_abnormal_mitochondrial_physio1.18155963
53MP0005503_abnormal_tendon_morphology1.17729539
54MP0002396_abnormal_hematopoietic_system1.15884479
55MP0003279_aneurysm1.15763614
56MP0005171_absent_coat_pigmentation1.12286731
57MP0010094_abnormal_chromosome_stability1.10944785
58* MP0000313_abnormal_cell_death1.10213349
59MP0000858_altered_metastatic_potential1.06615119
60MP0003448_altered_tumor_morphology1.06023059
61MP0008007_abnormal_cellular_replicative1.05488599
62MP0000749_muscle_degeneration1.04801367
63MP0005058_abnormal_lysosome_morphology1.04758303
64MP0002009_preneoplasia1.03416750
65* MP0002398_abnormal_bone_marrow1.03252456
66MP0000751_myopathy1.02886760
67MP0003566_abnormal_cell_adhesion1.02653114
68MP0004087_abnormal_muscle_fiber1.02508576
69MP0000733_abnormal_muscle_development1.02317557
70MP0001697_abnormal_embryo_size1.02056555
71MP0004272_abnormal_basement_membrane1.01711203
72MP0003959_abnormal_lean_body1.01361741
73MP0010329_abnormal_lipoprotein_level1.01143520
74MP0001533_abnormal_skeleton_physiology1.00810731
75* MP0001929_abnormal_gametogenesis0.99396579
76MP0003763_abnormal_thymus_physiology0.99047628
77MP0000681_abnormal_thyroid_gland0.98998407
78MP0005621_abnormal_cell_physiology0.97224183
79MP0001800_abnormal_humoral_immune0.96465069
80MP0001672_abnormal_embryogenesis/_devel0.96047874
81MP0005380_embryogenesis_phenotype0.96047874
82MP0001958_emphysema0.95243175
83MP0009333_abnormal_splenocyte_physiolog0.94982907
84MP0005623_abnormal_meninges_morphology0.94007307
85MP0002269_muscular_atrophy0.93607097
86MP0003984_embryonic_growth_retardation0.93146347
87MP0009785_altered_susceptibility_to0.92833530
88MP0002108_abnormal_muscle_morphology0.92773882
89MP0002405_respiratory_system_inflammati0.92403783
90MP0000609_abnormal_liver_physiology0.92039387
91MP0000678_abnormal_parathyroid_gland0.91792766
92MP0001348_abnormal_lacrimal_gland0.91715278
93MP0005501_abnormal_skin_physiology0.91066491
94MP0002452_abnormal_antigen_presenting0.90250445
95MP0003077_abnormal_cell_cycle0.90076537
96MP0005000_abnormal_immune_tolerance0.89890109
97MP0001790_abnormal_immune_system0.89459678
98MP0005387_immune_system_phenotype0.89459678
99* MP0002722_abnormal_immune_system0.89157732
100MP0001879_abnormal_lymphatic_vessel0.88871764
101MP0003828_pulmonary_edema0.87386322
102MP0001881_abnormal_mammary_gland0.87308147
103* MP0002420_abnormal_adaptive_immunity0.87133441
104MP0001243_abnormal_dermal_layer0.86214880
105MP0002088_abnormal_embryonic_growth/wei0.86149052
106MP0004947_skin_inflammation0.85105368
107* MP0001819_abnormal_immune_cell0.84962171
108* MP0000689_abnormal_spleen_morphology0.83810077
109MP0001346_abnormal_lacrimal_gland0.83061070
110MP0005671_abnormal_response_to0.82953165
111MP0002876_abnormal_thyroid_physiology0.82109380
112* MP0000703_abnormal_thymus_morphology0.81043191
113MP0001727_abnormal_embryo_implantation0.80834961
114MP0005025_abnormal_response_to0.80431305
115MP0002249_abnormal_larynx_morphology0.80344942
116MP0003091_abnormal_cell_migration0.80266448
117MP0005464_abnormal_platelet_physiology0.79971330
118* MP0002019_abnormal_tumor_incidence0.79692389
119MP0006138_congestive_heart_failure0.79459780
120MP0004147_increased_porphyrin_level0.78775538
121MP0002086_abnormal_extraembryonic_tissu0.77901455
122MP0000490_abnormal_crypts_of0.77385348
123* MP0000716_abnormal_immune_system0.76999124
124MP0005384_cellular_phenotype0.76977929
125MP0005023_abnormal_wound_healing0.76637588
126* MP0003698_abnormal_male_reproductive0.76228396
127MP0002419_abnormal_innate_immunity0.75933824
128MP0000358_abnormal_cell_content/0.74955601
129* MP0002429_abnormal_blood_cell0.74944377
130MP0005330_cardiomyopathy0.74149870
131MP0002723_abnormal_immune_serum0.73533302
132MP0003186_abnormal_redox_activity0.73268702
133MP0009250_abnormal_appendicular_skeleto0.72369792
134MP0002118_abnormal_lipid_homeostasis0.72303261
135MP0002085_abnormal_embryonic_tissue0.72174069
136MP0005220_abnormal_exocrine_pancreas0.71808828
137MP0003221_abnormal_cardiomyocyte_apopto0.71014640
138MP0010630_abnormal_cardiac_muscle0.69908499
139MP0009053_abnormal_anal_canal0.69709218
140MP0003950_abnormal_plasma_membrane0.69597350
141MP0001853_heart_inflammation0.69368500
142MP0003942_abnormal_urinary_system0.68920495
143MP0009931_abnormal_skin_appearance0.68630732
144MP0005083_abnormal_biliary_tract0.68135612
145MP0002998_abnormal_bone_remodeling0.67875475
146MP0002837_dystrophic_cardiac_calcinosis0.67752250
147MP0002933_joint_inflammation0.67724202
148MP0000465_gastrointestinal_hemorrhage0.67583840
149MP0004134_abnormal_chest_morphology0.66587976
150MP0000598_abnormal_liver_morphology0.66217914
151MP0005452_abnormal_adipose_tissue0.66088179

Predicted human phenotypes

RankGene SetZ-score
1Ankle contracture (HP:0006466)4.30736954
2Nasal polyposis (HP:0100582)4.03665328
3Premature rupture of membranes (HP:0001788)3.86198418
4Hypertriglyceridemia (HP:0002155)3.56766827
5Protrusio acetabuli (HP:0003179)3.47305829
6Abnormality of the nasal mucosa (HP:0000433)3.38164145
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.34412378
8Acanthosis nigricans (HP:0000956)3.32321365
9Osteolytic defects of the phalanges of the hand (HP:0009771)3.23216811
10Osteolytic defects of the hand bones (HP:0009699)3.23216811
11Recurrent bronchitis (HP:0002837)2.91292751
12Cervical subluxation (HP:0003308)2.85958783
13Cerebral aneurysm (HP:0004944)2.85850240
14Slender build (HP:0001533)2.85187799
15Insulin-resistant diabetes mellitus (HP:0000831)2.82753012
16Myocardial infarction (HP:0001658)2.76256913
17Broad distal phalanx of finger (HP:0009836)2.72468970
18Enlarged penis (HP:0000040)2.69137539
19Insomnia (HP:0100785)2.65639043
20Ulnar bowing (HP:0003031)2.61856101
21Cellulitis (HP:0100658)2.54162319
22Oligomenorrhea (HP:0000876)2.54080152
23Orthostatic hypotension (HP:0001278)2.53030272
24Aortic dissection (HP:0002647)2.52921942
25Increased connective tissue (HP:0009025)2.52289324
26High pitched voice (HP:0001620)2.49890076
27Insulin resistance (HP:0000855)2.49832704
28Cutaneous melanoma (HP:0012056)2.49597408
29Increased nuchal translucency (HP:0010880)2.45125403
30Growth hormone excess (HP:0000845)2.43545449
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43296945
32Ragged-red muscle fibers (HP:0003200)2.42333549
33Reduced subcutaneous adipose tissue (HP:0003758)2.40269814
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.39820695
35Absent/shortened dynein arms (HP:0200106)2.39820695
36Back pain (HP:0003418)2.39314140
37Bronchitis (HP:0012387)2.38973724
38Follicular hyperkeratosis (HP:0007502)2.35817982
39Type 1 muscle fiber predominance (HP:0003803)2.33465839
40Biconcave vertebral bodies (HP:0004586)2.31391227
41Soft skin (HP:0000977)2.30141647
42Progressive muscle weakness (HP:0003323)2.30091945
43Fragile skin (HP:0001030)2.29361291
44Abnormality of cells of the erythroid lineage (HP:0012130)2.24708956
45Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23383222
46Chromsome breakage (HP:0040012)2.20191151
47Neoplasm of head and neck (HP:0012288)2.19375989
48Esophageal neoplasm (HP:0100751)2.19375989
49Spinal rigidity (HP:0003306)2.18269683
50Autoimmune thrombocytopenia (HP:0001973)2.16543341
51Wormian bones (HP:0002645)2.16108077
52Abnormality of the umbilical cord (HP:0010881)2.13101475
53Chronic otitis media (HP:0000389)2.12895853
54Achilles tendon contracture (HP:0001771)2.11655238
55Difficulty running (HP:0009046)2.10721928
56Abnormality of complement system (HP:0005339)2.09394187
57Abnormality of skeletal muscle fiber size (HP:0012084)2.09302323
58Abnormality of glycolysis (HP:0004366)2.08885402
59Cholecystitis (HP:0001082)2.08781471
60Abnormal gallbladder physiology (HP:0012438)2.08781471
61Bladder diverticulum (HP:0000015)2.08716147
62Sparse lateral eyebrow (HP:0005338)2.08652239
63Polycythemia (HP:0001901)2.07120810
64Dilatation of the ascending aorta (HP:0005111)2.05693923
65Abnormality of the distal phalanges of the toes (HP:0010182)2.05603613
66Reticulocytosis (HP:0001923)2.04982407
67Abnormality of reticulocytes (HP:0004312)2.04742151
68Reticulocytopenia (HP:0001896)2.04234945
69Peritonitis (HP:0002586)2.04135556
70Papilloma (HP:0012740)2.03801087
71Verrucae (HP:0200043)2.03801087
72Recurrent sinusitis (HP:0011108)2.01932982
73Abnormality of the phalanges of the hallux (HP:0010057)1.98049645
74Aortic aneurysm (HP:0004942)1.97871787
75Abnormal number of erythroid precursors (HP:0012131)1.97252959
76Abnormality of the heme biosynthetic pathway (HP:0010472)1.96696443
77Abnormality of subcutaneous fat tissue (HP:0001001)1.96322232
78Flared metaphyses (HP:0003015)1.95930100
79Asymmetry of the thorax (HP:0001555)1.95750083
80Microvesicular hepatic steatosis (HP:0001414)1.95571858
81Breast hypoplasia (HP:0003187)1.94913155
82Nonimmune hydrops fetalis (HP:0001790)1.94577166
83Bone cyst (HP:0012062)1.94397140
84Abnormal umbilical cord blood vessels (HP:0011403)1.93452287
85Single umbilical artery (HP:0001195)1.93452287
86Abnormality of the fetal cardiovascular system (HP:0010948)1.93452287
87Pseudobulbar signs (HP:0002200)1.92623102
88Complement deficiency (HP:0004431)1.91971682
89Broad face (HP:0000283)1.90631210
90Increased density of long bones (HP:0006392)1.90537223
91Delayed cranial suture closure (HP:0000270)1.90219354
92Fatigue (HP:0012378)1.89305555
93Toxemia of pregnancy (HP:0100603)1.89084102
94Ileus (HP:0002595)1.88753977
95Deep philtrum (HP:0002002)1.88150617
96Hyperacusis (HP:0010780)1.87971209
97Myoglobinuria (HP:0002913)1.86874370
98Trismus (HP:0000211)1.86571854
99Mitral valve prolapse (HP:0001634)1.85716705
100Hemorrhage of the eye (HP:0011885)1.84832852
101Thrombocytosis (HP:0001894)1.84798543
102Combined immunodeficiency (HP:0005387)1.84698168
103Abnormality of the tricuspid valve (HP:0001702)1.84286962
104Squamous cell carcinoma (HP:0002860)1.83224818
105Cholelithiasis (HP:0001081)1.81546106
106Overlapping toe (HP:0001845)1.81154111
107Birth length less than 3rd percentile (HP:0003561)1.81056779
108Rhabdomyolysis (HP:0003201)1.80802822
109Vertebral compression fractures (HP:0002953)1.79755639
110Colitis (HP:0002583)1.79339371
111Dislocated radial head (HP:0003083)1.78424789
112Mitral regurgitation (HP:0001653)1.78405392
113Truncal obesity (HP:0001956)1.78300996
114Abnormality of the Achilles tendon (HP:0005109)1.77914679
115Ankyloglossia (HP:0010296)1.77880423
116Multiple enchondromatosis (HP:0005701)1.77479484
117Shallow orbits (HP:0000586)1.77309429
118Spinal cord lesions (HP:0100561)1.76933129
119Syringomyelia (HP:0003396)1.76933129
120Recurrent otitis media (HP:0000403)1.75854679
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75847887
122Generalized amyotrophy (HP:0003700)1.75433428
123Decreased subcutaneous fat (HP:0001002)1.75265583
124Venous abnormality (HP:0002624)1.74866953
125Poikilocytosis (HP:0004447)1.74339584
126Increased serum pyruvate (HP:0003542)1.73915115
127Deformed sella turcica (HP:0002681)1.73881405
128Infertility (HP:0000789)1.73727414
129Gonadotropin excess (HP:0000837)1.73235146
130Renal duplication (HP:0000075)1.73103027
131Gastrointestinal inflammation (HP:0004386)1.72581993
132Myositis (HP:0100614)1.72277350
133Abnormal hemoglobin (HP:0011902)1.71541676
134Hypertensive crisis (HP:0100735)1.71187980
135Genu recurvatum (HP:0002816)1.70535001
13611 pairs of ribs (HP:0000878)1.70209036
137Easy fatigability (HP:0003388)1.69901999
138Patellar dislocation (HP:0002999)1.69279814
139Abnormality of T cell physiology (HP:0011840)1.69253378
140J-shaped sella turcica (HP:0002680)1.68907385
141Inflammation of the large intestine (HP:0002037)1.68589203
142Short nail (HP:0001799)1.67467536
143Increased variability in muscle fiber diameter (HP:0003557)1.66289117
144Eczematoid dermatitis (HP:0000976)1.65934535
145Mildly elevated creatine phosphokinase (HP:0008180)1.65528447
146Distal lower limb amyotrophy (HP:0008944)1.64915400
147Absent frontal sinuses (HP:0002688)1.64874011
148Blue sclerae (HP:0000592)1.64747341
149Atrophic scars (HP:0001075)1.64077989
150Disproportionate tall stature (HP:0001519)1.63514444
151Abnormal spermatogenesis (HP:0008669)1.63425636
152Elbow flexion contracture (HP:0002987)1.62940830
153Abnormality of T cells (HP:0002843)1.62637689
154Broad metatarsal (HP:0001783)1.61934143
155Hallux valgus (HP:0001822)1.61324056
156Short middle phalanx of the 5th finger (HP:0004220)1.60970060
157Abnormality of T cell number (HP:0011839)1.60914934
158Bowel diverticulosis (HP:0005222)1.60764053
159Mucosal telangiectasiae (HP:0100579)1.60665422
160Chronic bronchitis (HP:0004469)1.60495183
161Ureteral duplication (HP:0000073)1.60278864
162Abnormality of the acetabulum (HP:0003170)1.60104112
163Mucopolysacchariduria (HP:0008155)1.59815531
164Urinary glycosaminoglycan excretion (HP:0003541)1.59815531
165Ulnar deviation of the wrist (HP:0003049)1.59553411
166Hyperpituitarism (HP:0010514)1.59394519
167Bronchiectasis (HP:0002110)1.59250962
168Entropion (HP:0000621)1.58692743
169Abnormality of oral frenula (HP:0000190)1.58626602
170Spinal cord compression (HP:0002176)1.58503716
171Overriding aorta (HP:0002623)1.58191768
172Increased muscle lipid content (HP:0009058)1.57670338
173Hyperthyroidism (HP:0000836)1.57303567
174Metatarsus adductus (HP:0001840)1.57222414
175Slender long bone (HP:0003100)1.57183284
176Relative macrocephaly (HP:0004482)1.57159980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.86814985
2PDK33.29049768
3PDK43.29049768
4SIK12.71249040
5SMG12.70228679
6PRPF4B2.70157574
7EEF2K2.68345386
8MAP3K102.54086159
9CAMK1D2.50323016
10NEK22.47014678
11IRAK32.44508439
12PKN22.43134508
13TESK12.37243025
14EIF2AK12.31877667
15PBK2.17600971
16ERN12.11564407
17CDC72.10702946
18CDK81.81060809
19NEK11.77471394
20STK101.70248955
21PDK21.66646832
22CAMK1G1.53619109
23TESK21.46474295
24CDK61.45918486
25MAP4K11.44499584
26LRRK21.38675852
27CDK71.35671391
28TTN1.31778862
29BUB11.29234488
30PRKD31.28463920
31DYRK1B1.26618689
32CCNB11.26604887
33CHEK21.26071893
34AURKA1.17502850
35CDK41.17308339
36NEK91.17289449
37ZAP701.15003758
38STK41.14317111
39STK31.13016507
40PASK1.12499476
41ARAF1.12311762
42BCKDK1.09809176
43RPS6KA41.09033219
44BRAF1.08663337
45KSR21.07707978
46TAOK21.07466659
47RIPK11.06627710
48PIM11.05427695
49TYK21.02717541
50NME21.02388937
51CDK91.02218215
52TGFBR21.01390810
53PTK61.00767054
54PDGFRA0.99390768
55JAK10.96993843
56BRSK20.96111034
57MAP2K30.94683037
58FLT30.93625528
59ICK0.92267387
60PIM20.92180989
61JAK30.91947903
62TLK10.91447325
63CSF1R0.91082633
64TRPM70.90300595
65SCYL20.89372763
66CLK10.88951074
67VRK20.88942172
68RAF10.88327883
69CHEK10.88114945
70ILK0.87187152
71MAPK110.86804125
72FGFR30.86007675
73STK160.85400919
74TBK10.82976047
75SRPK10.79238291
76LMTK20.78228081
77BTK0.75405757
78AURKB0.75396261
79MAP3K130.73762711
80ATR0.73410491
81FRK0.73244079
82GRK60.73223616
83BMX0.72094195
84JAK20.70261336
85ABL20.69254783
86TNK20.67967632
87PTK2B0.67386483
88AKT20.67040248
89LATS20.65991406
90MAP3K80.65239513
91BRSK10.65228348
92IRAK20.65098680
93PAK40.62633210
94PAK10.62087874
95PDGFRB0.60747557
96PLK40.59146967
97DMPK0.59109862
98CDK120.58428422
99MOS0.58043890
100FGFR40.56858007
101EPHB10.56572127
102DYRK30.56264870
103LATS10.55898413
104ZAK0.55442512
105RPS6KA50.55272769
106PAK20.54874162
107HIPK20.54754436
108MAPKAPK50.53919240
109WEE10.53494420
110MTOR0.53400379
111CSK0.52506697
112MST1R0.52463891
113CAMKK20.52359026
114TEC0.52193699
115CDK10.51063666
116PRKAA20.50691663
117PTK20.50581104
118CDK20.50329470
119MYLK0.49848205
120PDPK10.46889929
121KIT0.46695481
122CDK11A0.46262186
123DDR20.45897794
124SYK0.45200514
125PDK10.45171994
126MAP3K30.44723178
127KDR0.44345473
128MAPKAPK20.43588883
129CDK150.43567237
130RPS6KB20.43505908
131HCK0.42168998
132TTK0.41924295
133ITK0.41502521
134INSRR0.41411392
135IKBKE0.40784775
136CHUK0.40649804
137MELK0.39570789
138MAP3K60.38293132
139BLK0.38118194
140LIMK10.38086321
141PLK10.38030957
142CDK180.37390474
143IKBKB0.37235684
144MAPK40.36550916
145MAPK120.36355647
146MAP2K10.36054701
147ERBB40.34240199
148CDK140.32975197
149ATM0.32624122
150CSNK2A20.29135876
151VRK10.28701415

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.05494899
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.72601136
3Ribosome_Homo sapiens_hsa030102.65012734
4PPAR signaling pathway_Homo sapiens_hsa033202.59966021
5DNA replication_Homo sapiens_hsa030302.58165187
6Propanoate metabolism_Homo sapiens_hsa006402.40098864
7Systemic lupus erythematosus_Homo sapiens_hsa053222.16622176
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95776138
9Fatty acid metabolism_Homo sapiens_hsa012121.88754182
10Spliceosome_Homo sapiens_hsa030401.86880064
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85560588
12Pentose phosphate pathway_Homo sapiens_hsa000301.75293732
13Biosynthesis of amino acids_Homo sapiens_hsa012301.71674831
14Adipocytokine signaling pathway_Homo sapiens_hsa049201.69061594
15Fatty acid degradation_Homo sapiens_hsa000711.65283140
16Glycerolipid metabolism_Homo sapiens_hsa005611.64931929
17Pyrimidine metabolism_Homo sapiens_hsa002401.61316516
18Primary immunodeficiency_Homo sapiens_hsa053401.58218365
19Fatty acid elongation_Homo sapiens_hsa000621.55887435
20AMPK signaling pathway_Homo sapiens_hsa041521.51864813
21Antigen processing and presentation_Homo sapiens_hsa046121.50694820
22Caffeine metabolism_Homo sapiens_hsa002321.49592597
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.49171523
24Small cell lung cancer_Homo sapiens_hsa052221.48694768
25Pyruvate metabolism_Homo sapiens_hsa006201.47783232
26* Cell cycle_Homo sapiens_hsa041101.47348715
27Chronic myeloid leukemia_Homo sapiens_hsa052201.45994330
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45138476
29Base excision repair_Homo sapiens_hsa034101.42605249
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41682855
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38370873
32p53 signaling pathway_Homo sapiens_hsa041151.36992893
33RNA transport_Homo sapiens_hsa030131.35969285
34Viral carcinogenesis_Homo sapiens_hsa052031.31496464
35Mismatch repair_Homo sapiens_hsa034301.26164532
36Glioma_Homo sapiens_hsa052141.24674884
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19999284
38Insulin resistance_Homo sapiens_hsa049311.18184694
39Carbon metabolism_Homo sapiens_hsa012001.14386012
40Toxoplasmosis_Homo sapiens_hsa051451.12871046
41Measles_Homo sapiens_hsa051621.12518753
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.11283799
43Staphylococcus aureus infection_Homo sapiens_hsa051501.11190249
44B cell receptor signaling pathway_Homo sapiens_hsa046621.10516186
45Pancreatic cancer_Homo sapiens_hsa052121.08040829
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06132535
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05704530
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03539032
49mRNA surveillance pathway_Homo sapiens_hsa030151.02904306
50Osteoclast differentiation_Homo sapiens_hsa043801.02369481
51Vitamin B6 metabolism_Homo sapiens_hsa007500.98088015
52Acute myeloid leukemia_Homo sapiens_hsa052210.97282624
53Legionellosis_Homo sapiens_hsa051340.96221109
54Homologous recombination_Homo sapiens_hsa034400.95777251
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95558227
56ECM-receptor interaction_Homo sapiens_hsa045120.95106188
57Apoptosis_Homo sapiens_hsa042100.94698099
58Selenocompound metabolism_Homo sapiens_hsa004500.94003069
59Melanoma_Homo sapiens_hsa052180.92539428
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92066542
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.89334991
62* HTLV-I infection_Homo sapiens_hsa051660.88854211
63Malaria_Homo sapiens_hsa051440.88660230
64Viral myocarditis_Homo sapiens_hsa054160.87836079
65Non-homologous end-joining_Homo sapiens_hsa034500.87711099
66Insulin signaling pathway_Homo sapiens_hsa049100.87629647
67Focal adhesion_Homo sapiens_hsa045100.87282816
68N-Glycan biosynthesis_Homo sapiens_hsa005100.86080490
69Fructose and mannose metabolism_Homo sapiens_hsa000510.85367735
70Folate biosynthesis_Homo sapiens_hsa007900.85021565
71Leishmaniasis_Homo sapiens_hsa051400.84992410
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84491277
73Prion diseases_Homo sapiens_hsa050200.83961836
74Fanconi anemia pathway_Homo sapiens_hsa034600.83690759
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83395868
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.81786954
77Hepatitis B_Homo sapiens_hsa051610.81544502
78Protein digestion and absorption_Homo sapiens_hsa049740.79905406
79Renal cell carcinoma_Homo sapiens_hsa052110.79697104
80Galactose metabolism_Homo sapiens_hsa000520.79139807
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78366059
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78317197
83Glucagon signaling pathway_Homo sapiens_hsa049220.75014097
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.74949985
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74904657
86* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74838889
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74086263
88Bladder cancer_Homo sapiens_hsa052190.73876959
89Oocyte meiosis_Homo sapiens_hsa041140.73344562
90Herpes simplex infection_Homo sapiens_hsa051680.73143826
91Endometrial cancer_Homo sapiens_hsa052130.72294246
92Phenylalanine metabolism_Homo sapiens_hsa003600.70124275
93Nucleotide excision repair_Homo sapiens_hsa034200.68568616
94Other glycan degradation_Homo sapiens_hsa005110.68280318
95Fat digestion and absorption_Homo sapiens_hsa049750.67817313
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.67779311
97Prostate cancer_Homo sapiens_hsa052150.67604557
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.66854353
99Non-small cell lung cancer_Homo sapiens_hsa052230.66645491
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66528346
101Glutathione metabolism_Homo sapiens_hsa004800.64641751
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64241420
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64199862
104MicroRNAs in cancer_Homo sapiens_hsa052060.64070260
105Lysosome_Homo sapiens_hsa041420.63336127
106ABC transporters_Homo sapiens_hsa020100.62407800
107RNA polymerase_Homo sapiens_hsa030200.62359043
108Purine metabolism_Homo sapiens_hsa002300.62085267
109Proteoglycans in cancer_Homo sapiens_hsa052050.60951844
110Platelet activation_Homo sapiens_hsa046110.59973977
111Alcoholism_Homo sapiens_hsa050340.58586007
112Colorectal cancer_Homo sapiens_hsa052100.58259064
113Epstein-Barr virus infection_Homo sapiens_hsa051690.57072915
114Sulfur relay system_Homo sapiens_hsa041220.56929327
115FoxO signaling pathway_Homo sapiens_hsa040680.55625410
116T cell receptor signaling pathway_Homo sapiens_hsa046600.55359203
117Proteasome_Homo sapiens_hsa030500.54573851
118Lysine degradation_Homo sapiens_hsa003100.54567291
119HIF-1 signaling pathway_Homo sapiens_hsa040660.52467132
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51843561
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51619787
122Hematopoietic cell lineage_Homo sapiens_hsa046400.50792383
123Amoebiasis_Homo sapiens_hsa051460.50488480
124Autoimmune thyroid disease_Homo sapiens_hsa053200.50254715
125Thyroid cancer_Homo sapiens_hsa052160.50036376
126Shigellosis_Homo sapiens_hsa051310.45332120
127VEGF signaling pathway_Homo sapiens_hsa043700.44792082
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44718620
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44365208
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43228783
131Notch signaling pathway_Homo sapiens_hsa043300.43041915
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.42829437
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42491018
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41699269
135One carbon pool by folate_Homo sapiens_hsa006700.41396806
136mTOR signaling pathway_Homo sapiens_hsa041500.41096257
137Influenza A_Homo sapiens_hsa051640.41042211
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38851248
139Renin-angiotensin system_Homo sapiens_hsa046140.37708447
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.33870304
141Tyrosine metabolism_Homo sapiens_hsa003500.32438536

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