CDKN2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)5.07485857
2neutrophil activation involved in immune response (GO:0002283)4.61968848
3positive regulation by symbiont of host defense response (GO:0052509)4.44918889
4modulation by symbiont of host defense response (GO:0052031)4.44918889
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.44918889
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.44918889
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.44918889
8modulation by symbiont of host immune response (GO:0052553)4.44918889
9leukocyte migration involved in inflammatory response (GO:0002523)4.36399603
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.28271089
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.20268390
12antigen processing and presentation of endogenous antigen (GO:0019883)4.19369817
13negative regulation of microtubule polymerization (GO:0031115)3.91301823
14activated T cell proliferation (GO:0050798)3.90647388
15macrophage activation involved in immune response (GO:0002281)3.82823086
16leukocyte aggregation (GO:0070486)3.72805802
17synaptic vesicle exocytosis (GO:0016079)3.68616581
18microglial cell activation (GO:0001774)3.67191585
19positive regulation of mast cell activation (GO:0033005)3.65219898
20neutrophil activation (GO:0042119)3.58864978
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58593507
22negative regulation of lymphocyte mediated immunity (GO:0002707)3.51605288
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.48740545
24detection of other organism (GO:0098543)3.43403195
25ATP synthesis coupled proton transport (GO:0015986)3.38897126
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38897126
27negative regulation of cell killing (GO:0031342)3.38722195
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38722195
29detection of bacterium (GO:0016045)3.34885663
30cellular extravasation (GO:0045123)3.24253993
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.24147154
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23498440
33response to host immune response (GO:0052572)3.23498440
34chaperone-mediated protein transport (GO:0072321)3.23097057
35negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.18342230
36granulocyte activation (GO:0036230)3.15348311
37response to peptidoglycan (GO:0032494)3.10576986
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10329408
39myeloid cell activation involved in immune response (GO:0002275)3.08658506
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.05960644
41mast cell activation involved in immune response (GO:0002279)3.04951642
42mast cell degranulation (GO:0043303)3.04951642
43pyrimidine nucleobase catabolic process (GO:0006208)3.03800136
44negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.03573815
45neuron cell-cell adhesion (GO:0007158)3.01460453
46transferrin transport (GO:0033572)2.99733709
47regulation of interferon-beta biosynthetic process (GO:0045357)2.98726385
48mast cell activation (GO:0045576)2.98073457
49regulation of mast cell degranulation (GO:0043304)2.97263777
50regulation of gamma-delta T cell activation (GO:0046643)2.96431123
51phagosome maturation (GO:0090382)2.94765003
52regulation of mast cell activation (GO:0033003)2.94304606
53positive regulation of mast cell activation involved in immune response (GO:0033008)2.93374590
54positive regulation of mast cell degranulation (GO:0043306)2.93374590
55protein neddylation (GO:0045116)2.91621902
56negative regulation of leukocyte mediated immunity (GO:0002704)2.91501673
57immunoglobulin mediated immune response (GO:0016064)2.90371503
58negative regulation of dendrite morphogenesis (GO:0050774)2.90166147
59regulation of T-helper 2 cell differentiation (GO:0045628)2.86674139
60regulation of defense response to virus by virus (GO:0050690)2.85972791
61macrophage activation (GO:0042116)2.84714597
62synaptic transmission, dopaminergic (GO:0001963)2.84558293
63regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.84147884
64regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.84147884
65positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81837462
66regulation of platelet aggregation (GO:0090330)2.81707771
67energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.81328893
68ATP hydrolysis coupled proton transport (GO:0015991)2.81328893
69tolerance induction (GO:0002507)2.81201438
70microtubule depolymerization (GO:0007019)2.80272732
71regulation of isotype switching to IgG isotypes (GO:0048302)2.80182869
72protein complex biogenesis (GO:0070271)2.79643047
73neutrophil mediated immunity (GO:0002446)2.79104448
74antigen processing and presentation via MHC class Ib (GO:0002475)2.77760840
75cellular response to interleukin-15 (GO:0071350)2.77594890
76response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77378916
77response to host (GO:0075136)2.77378916
78response to host defenses (GO:0052200)2.77378916
79regulation of mast cell activation involved in immune response (GO:0033006)2.77336105
80negative regulation of calcium ion transport into cytosol (GO:0010523)2.77025827
81negative regulation of T-helper cell differentiation (GO:0045623)2.75477342
82negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.75477342
83detection of external biotic stimulus (GO:0098581)2.74903024
84negative regulation of T cell mediated immunity (GO:0002710)2.74839530
85microtubule polymerization or depolymerization (GO:0031109)2.74623956
86neuronal action potential propagation (GO:0019227)2.71067212
87regulation of regulated secretory pathway (GO:1903305)2.70516694
88negative regulation of interleukin-12 production (GO:0032695)2.69141535
89regulation of synaptic vesicle exocytosis (GO:2000300)2.68408968
90cullin deneddylation (GO:0010388)2.66109653
91negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.65076032
92regulation of gamma-delta T cell differentiation (GO:0045586)2.63380191
93regulation of synapse structural plasticity (GO:0051823)2.63090745
94regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.63011650
95regulation of natural killer cell mediated immunity (GO:0002715)2.63011650
96trivalent inorganic cation transport (GO:0072512)2.62657958
97ferric iron transport (GO:0015682)2.62657958
98regulation of myeloid leukocyte mediated immunity (GO:0002886)2.61614343
99myeloid leukocyte mediated immunity (GO:0002444)2.59098577
100protein localization to synapse (GO:0035418)2.57988424
101negative regulation of erythrocyte differentiation (GO:0045647)2.57680088
102establishment of mitochondrion localization (GO:0051654)2.57383728
103protein deneddylation (GO:0000338)2.56474568
104respiratory electron transport chain (GO:0022904)2.56469736
105positive regulation of gamma-delta T cell activation (GO:0046645)2.56124471
106electron transport chain (GO:0022900)2.54274017
107mitochondrial respiratory chain complex I assembly (GO:0032981)2.53851335
108NADH dehydrogenase complex assembly (GO:0010257)2.53851335
109mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53851335
110response to interleukin-15 (GO:0070672)2.53382363
111deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.52832589
112synaptic vesicle maturation (GO:0016188)2.51267898
113mitotic sister chromatid segregation (GO:0000070)2.50699810
114negative regulation of type 2 immune response (GO:0002829)2.50128657
115negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.48585130
116mitochondrial respiratory chain complex assembly (GO:0033108)2.47557412
117positive regulation of regulated secretory pathway (GO:1903307)2.47292210
118actin filament polymerization (GO:0030041)2.47177018
119detection of molecule of bacterial origin (GO:0032490)2.46446092
120regulation of B cell receptor signaling pathway (GO:0050855)2.46300625
121negative T cell selection (GO:0043383)2.46279952
122adaptation of signaling pathway (GO:0023058)2.46268091
123regulation of regulatory T cell differentiation (GO:0045589)2.45808799
124negative regulation of cation channel activity (GO:2001258)2.45127013
125positive regulation of neurotransmitter transport (GO:0051590)2.42915437
126negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.41841175
127negative regulation of ligase activity (GO:0051352)2.41841175
128Arp2/3 complex-mediated actin nucleation (GO:0034314)2.41601320
129regulation of synaptic transmission, dopaminergic (GO:0032225)2.41584825
130positive regulation of granulocyte differentiation (GO:0030854)2.40290298
131locomotory exploration behavior (GO:0035641)2.39378270
132signal complex assembly (GO:0007172)2.39270367
133regulation of leukocyte degranulation (GO:0043300)2.39093395
134negative regulation of immunoglobulin mediated immune response (GO:0002890)2.38238452
135negative regulation of B cell mediated immunity (GO:0002713)2.38238452
136behavioral response to ethanol (GO:0048149)2.38106662
137respiratory burst (GO:0045730)2.37845323
138regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.37580860
139detection of biotic stimulus (GO:0009595)2.37351269
140production of molecular mediator involved in inflammatory response (GO:0002532)2.37174019
141positive regulation of type 2 immune response (GO:0002830)2.36768395
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.36569428
143positive regulation of B cell differentiation (GO:0045579)2.36553591
144neurofilament cytoskeleton organization (GO:0060052)2.35767513
145inositol phosphate catabolic process (GO:0071545)2.35016302
146regulation of synaptic vesicle transport (GO:1902803)2.34353697
147negative regulation of phagocytosis (GO:0050765)2.34260734
148anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.33684124
149regulated secretory pathway (GO:0045055)2.32906902
150mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.32341077
151ionotropic glutamate receptor signaling pathway (GO:0035235)2.31241285
152DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.31030384
153leukocyte degranulation (GO:0043299)2.30363287
154regulation of protein kinase A signaling (GO:0010738)2.29711075
155intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.29565526
156signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.29565526
157glutamate secretion (GO:0014047)2.28926409
158negative thymic T cell selection (GO:0045060)2.28790945
159positive regulation of synaptic transmission, GABAergic (GO:0032230)2.26443603
160signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.26220005
161signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.26220005
162signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.26220005
163regulation of short-term neuronal synaptic plasticity (GO:0048172)2.25953880
164T cell receptor signaling pathway (GO:0050852)2.25673133
165behavioral response to cocaine (GO:0048148)2.24892351
166antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.24322890
167negative regulation of execution phase of apoptosis (GO:1900118)2.24116872
168detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.23989890
169detection of temperature stimulus involved in sensory perception (GO:0050961)2.23989890
170response to insecticide (GO:0017085)2.22283762
171synaptic vesicle docking involved in exocytosis (GO:0016081)2.21813412
172T cell migration (GO:0072678)2.19008640
173regulation of cellular amino acid metabolic process (GO:0006521)2.17469850
174hydrogen ion transmembrane transport (GO:1902600)2.17046859
175antigen receptor-mediated signaling pathway (GO:0050851)2.16720512
176B cell receptor signaling pathway (GO:0050853)2.15606544
177regulation of catecholamine metabolic process (GO:0042069)2.15426313
178regulation of dopamine metabolic process (GO:0042053)2.15426313
179regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.14128603
180protein depolymerization (GO:0051261)2.13382946
181deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.13126051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.64051452
2EZH2_22144423_ChIP-Seq_EOC_Human3.08256025
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98879414
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.82141005
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53838149
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.50760408
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.42833108
8PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.37770702
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.36722028
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31228154
11* FOXM1_23109430_ChIP-Seq_U2OS_Human2.30199511
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27186837
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.26856342
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.25245764
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23079108
16E2F7_22180533_ChIP-Seq_HELA_Human2.18803855
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16341472
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.14505647
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11539601
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05142608
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04825909
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02274366
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01685351
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01003499
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00338801
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.95796067
27DROSHA_22980978_ChIP-Seq_HELA_Human1.95524535
28SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.93473325
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90998888
30* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90579664
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90289423
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82721886
33* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82200314
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81402288
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78354815
36* VDR_23849224_ChIP-Seq_CD4+_Human1.77389468
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77069653
38* IRF8_27001747_Chip-Seq_BMDM_Mouse1.75194452
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75049015
40FOXP3_21729870_ChIP-Seq_TREG_Human1.73954807
41* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73688820
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72575465
43TAF15_26573619_Chip-Seq_HEK293_Human1.70745257
44* YY1_21170310_ChIP-Seq_MESCs_Mouse1.68174291
45* GATA1_19941827_ChIP-Seq_MEL_Mouse1.67972916
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64977427
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62744680
48* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62008672
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61218140
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.58080757
51SCL_19346495_ChIP-Seq_HPC-7_Human1.57328217
52KDM2B_26808549_Chip-Seq_DND41_Human1.56758211
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56392166
54SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56024655
55* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54269325
56* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52869390
57RUNX_20019798_ChIP-Seq_JUKART_Human1.52546495
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.52521868
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51327295
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49681950
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.48383570
62REST_21632747_ChIP-Seq_MESCs_Mouse1.46626898
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45713189
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45277402
65KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.44790849
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.42961826
67VDR_24763502_ChIP-Seq_THP-1_Human1.42654003
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40350979
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37116663
70* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36210127
71SPI1_23547873_ChIP-Seq_NB4_Human1.35166038
72MYB_26560356_Chip-Seq_TH2_Human1.33993805
73TCF7_22412390_ChIP-Seq_EML_Mouse1.33827493
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32257941
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31951962
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31916675
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.30765977
78* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30099122
79STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29979016
80GATA1_19941826_ChIP-Seq_K562_Human1.29676204
81* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29085988
82BCL6_27268052_Chip-Seq_Bcells_Human1.28409397
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26675353
84* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26533729
85ELK1_19687146_ChIP-ChIP_HELA_Human1.25898807
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25133412
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24888239
88GBX2_23144817_ChIP-Seq_PC3_Human1.23866188
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23544097
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22821319
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22363784
92* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22199712
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21585754
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20306395
95VDR_21846776_ChIP-Seq_THP-1_Human1.19442223
96LXR_22292898_ChIP-Seq_THP-1_Human1.19250484
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19097007
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18893351
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18801179
100STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18529304
101GABP_19822575_ChIP-Seq_HepG2_Human1.18006776
102CIITA_25753668_ChIP-Seq_RAJI_Human1.17447852
103DCP1A_22483619_ChIP-Seq_HELA_Human1.17284622
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16353895
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16053333
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15968738
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15688973
108KDM2B_26808549_Chip-Seq_K562_Human1.14772989
109EZH2_27304074_Chip-Seq_ESCs_Mouse1.14093086
110OCT4_19829295_ChIP-Seq_ESCs_Human1.13259530
111XRN2_22483619_ChIP-Seq_HELA_Human1.12502511
112RNF2_27304074_Chip-Seq_ESCs_Mouse1.11863531
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11273474
114UTX_26944678_Chip-Seq_JUKART_Human1.10807637
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10705824
116GATA3_27048872_Chip-Seq_THYMUS_Human1.10000262
117* MAF_26560356_Chip-Seq_TH1_Human1.07205450
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06595829
119* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04803873
120* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04047967
121RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03987538
122RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03658064
123SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03377863
124PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02693779
125EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01680700
126ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01230340
127* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01119475
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01098569
129BCOR_27268052_Chip-Seq_Bcells_Human1.01096283
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00958745
131RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00141879
132CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99884364
133* TTF2_22483619_ChIP-Seq_HELA_Human0.99328491
134GATA2_19941826_ChIP-Seq_K562_Human0.97966259
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96344358
136RARB_27405468_Chip-Seq_BRAIN_Mouse0.95740992
137* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94994086
138MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94626441
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.94564283
140RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93950889
141EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93950889
142SPI1_20517297_ChIP-Seq_HL60_Human0.93574708
143GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93285949
144SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93176905
145P68_20966046_ChIP-Seq_HELA_Human0.92639395
146BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91556858
147MAF_26560356_Chip-Seq_TH2_Human0.90547655
148MYB_26560356_Chip-Seq_TH1_Human0.90324686
149BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89673567
150IRF8_22096565_ChIP-ChIP_GC-B_Human0.88905516
151CTCF_27219007_Chip-Seq_Bcells_Human0.88823293
152RUNX1_22412390_ChIP-Seq_EML_Mouse0.88797373
153CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88293189
154JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87909326
155MYC_18940864_ChIP-ChIP_HL60_Human0.86849810
156PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86755989
157ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86724160
158* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86462928
159SMAD_19615063_ChIP-ChIP_OVARY_Human0.85726530
160SPI1_23127762_ChIP-Seq_K562_Human0.84075100
161MYC_22102868_ChIP-Seq_BL_Human0.84011464
162SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82874815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.39647329
2MP0002735_abnormal_chemical_nociception3.33314882
3MP0001968_abnormal_touch/_nociception3.04907488
4MP0002736_abnormal_nociception_after2.88395809
5MP0004859_abnormal_synaptic_plasticity2.83030690
6MP0001529_abnormal_vocalization2.60928107
7MP0003303_peritoneal_inflammation2.42754577
8MP0006276_abnormal_autonomic_nervous2.30235818
9MP0006082_CNS_inflammation2.30094718
10MP0005671_abnormal_response_to2.22708873
11MP0003635_abnormal_synaptic_transmissio2.21559439
12MP0001986_abnormal_taste_sensitivity2.21305459
13MP0001905_abnormal_dopamine_level2.19589743
14MP0009745_abnormal_behavioral_response2.19004141
15MP0002064_seizures2.07723061
16MP0004270_analgesia2.07350006
17MP0001970_abnormal_pain_threshold2.07254945
18MP0002734_abnormal_mechanical_nocicepti1.99517745
19MP0002272_abnormal_nervous_system1.97938747
20MP0003763_abnormal_thymus_physiology1.94165986
21MP0004147_increased_porphyrin_level1.92505821
22MP0002733_abnormal_thermal_nociception1.88312546
23MP0008004_abnormal_stomach_pH1.80207749
24MP0002063_abnormal_learning/memory/cond1.79668181
25MP0002572_abnormal_emotion/affect_behav1.77312051
26MP0003656_abnormal_erythrocyte_physiolo1.76449814
27MP0009785_altered_susceptibility_to1.74932942
28MP0003122_maternal_imprinting1.72598278
29MP0009046_muscle_twitch1.64047521
30MP0008877_abnormal_DNA_methylation1.56973616
31MP0002398_abnormal_bone_marrow1.53327189
32MP0001835_abnormal_antigen_presentation1.50713313
33MP0002420_abnormal_adaptive_immunity1.45636315
34MP0002067_abnormal_sensory_capabilities1.45593206
35MP0005000_abnormal_immune_tolerance1.43768244
36MP0001819_abnormal_immune_cell1.41913453
37MP0005423_abnormal_somatic_nervous1.41676183
38MP0001800_abnormal_humoral_immune1.41352625
39MP0003183_abnormal_peptide_metabolism1.39941695
40MP0001533_abnormal_skeleton_physiology1.33651334
41MP0004811_abnormal_neuron_physiology1.33236362
42MP0004130_abnormal_muscle_cell1.30365168
43MP0008260_abnormal_autophagy1.28979667
44MP0003436_decreased_susceptibility_to1.28780481
45MP0002396_abnormal_hematopoietic_system1.28741729
46MP0002723_abnormal_immune_serum1.28172508
47MP0003866_abnormal_defecation1.27993987
48MP0001501_abnormal_sleep_pattern1.26520061
49MP0000703_abnormal_thymus_morphology1.26491064
50MP0003121_genomic_imprinting1.26391609
51MP0009333_abnormal_splenocyte_physiolog1.26279180
52MP0008569_lethality_at_weaning1.23850862
53MP0004142_abnormal_muscle_tone1.22968035
54MP0003787_abnormal_imprinting1.21554874
55MP0001790_abnormal_immune_system1.21197373
56MP0005387_immune_system_phenotype1.21197373
57MP0000716_abnormal_immune_system1.20745859
58MP0002822_catalepsy1.19744673
59MP0005646_abnormal_pituitary_gland1.18897592
60MP0001851_eye_inflammation1.17237398
61MP0002184_abnormal_innervation1.16863075
62MP0002452_abnormal_antigen_presenting1.16191322
63MP0009764_decreased_sensitivity_to1.15177733
64MP0001440_abnormal_grooming_behavior1.14071935
65MP0001984_abnormal_olfaction1.13995055
66MP0002722_abnormal_immune_system1.13683573
67MP0004924_abnormal_behavior1.11869847
68MP0005386_behavior/neurological_phenoty1.11869847
69MP0001486_abnormal_startle_reflex1.11303165
70MP0005025_abnormal_response_to1.10525479
71MP0000689_abnormal_spleen_morphology1.09741821
72MP0000685_abnormal_immune_system1.09186041
73MP0002148_abnormal_hypersensitivity_rea1.08526059
74MP0002429_abnormal_blood_cell1.07523108
75MP0002751_abnormal_autonomic_nervous1.06708679
76MP0001663_abnormal_digestive_system1.06031846
77MP0004808_abnormal_hematopoietic_stem1.05920765
78MP0001845_abnormal_inflammatory_respons1.05081444
79MP0004510_myositis1.04609353
80MP0002557_abnormal_social/conspecific_i1.03298636
81MP0008872_abnormal_physiological_respon1.03262319
82MP0001188_hyperpigmentation1.01692293
83MP0008874_decreased_physiological_sensi1.01619079
84MP0002405_respiratory_system_inflammati1.01027430
85MP0010155_abnormal_intestine_physiology1.00660875
86MP0003693_abnormal_embryo_hatching0.99856616
87MP0003724_increased_susceptibility_to0.99826447
88MP0002653_abnormal_ependyma_morphology0.98562016
89MP0005645_abnormal_hypothalamus_physiol0.97956464
90MP0004947_skin_inflammation0.97265519
91MP0010094_abnormal_chromosome_stability0.96350667
92MP0004742_abnormal_vestibular_system0.96203440
93MP0003172_abnormal_lysosome_physiology0.95923987
94MP0005310_abnormal_salivary_gland0.95458581
95MP0005083_abnormal_biliary_tract0.93899195
96MP0002638_abnormal_pupillary_reflex0.93723944
97MP0002419_abnormal_innate_immunity0.93054972
98MP0002132_abnormal_respiratory_system0.92238531
99MP0003690_abnormal_glial_cell0.91252819
100MP0006036_abnormal_mitochondrial_physio0.90968548
101MP0005464_abnormal_platelet_physiology0.89943516
102MP0002163_abnormal_gland_morphology0.89578182
103MP0005410_abnormal_fertilization0.89130708
104MP0009765_abnormal_xenobiotic_induced0.88632502
105MP0002102_abnormal_ear_morphology0.87747531
106MP0003828_pulmonary_edema0.85182701
107MP0005535_abnormal_body_temperature0.84881345
108MP0000920_abnormal_myelination0.84159238
109MP0009278_abnormal_bone_marrow0.83935366
110MP0000372_irregular_coat_pigmentation0.83059110
111MP0002928_abnormal_bile_duct0.82705615
112MP0004858_abnormal_nervous_system0.81848918
113MP0003300_gastrointestinal_ulcer0.81790275
114MP0000343_altered_response_to0.81084039
115MP0010386_abnormal_urinary_bladder0.80880282
116MP0003329_amyloid_beta_deposits0.80201002
117MP0005084_abnormal_gallbladder_morpholo0.79651895
118MP0003077_abnormal_cell_cycle0.79251451
119MP0002066_abnormal_motor_capabilities/c0.78026069
120MP0002095_abnormal_skin_pigmentation0.77583830
121* MP0003879_abnormal_hair_cell0.76428812
122* MP0002882_abnormal_neuron_morphology0.76201202
123MP0005397_hematopoietic_system_phenotyp0.76159288
124MP0001545_abnormal_hematopoietic_system0.76159288
125MP0000955_abnormal_spinal_cord0.73715910
126MP0008058_abnormal_DNA_repair0.73615101
127MP0002837_dystrophic_cardiac_calcinosis0.72966860
128MP0000015_abnormal_ear_pigmentation0.72781618
129MP0000465_gastrointestinal_hemorrhage0.69939853

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)5.63524851
2Myokymia (HP:0002411)4.56568279
3Abnormality of macrophages (HP:0004311)3.96239770
4Acute necrotizing encephalopathy (HP:0006965)3.91789492
5Abnormal hair whorl (HP:0010721)3.86710719
6Abnormal platelet volume (HP:0011876)3.84637544
7Menorrhagia (HP:0000132)3.70748018
8Diplopia (HP:0000651)3.69187796
9Abnormality of binocular vision (HP:0011514)3.69187796
10Gingival bleeding (HP:0000225)3.64546798
11Epistaxis (HP:0000421)3.64094335
12Myositis (HP:0100614)3.62377272
13Abnormal mitochondria in muscle tissue (HP:0008316)3.60295163
14Focal motor seizures (HP:0011153)3.58319910
15Mitochondrial inheritance (HP:0001427)3.46537102
16Retrobulbar optic neuritis (HP:0100654)3.42311248
17Optic neuritis (HP:0100653)3.42311248
18Hypochromic microcytic anemia (HP:0004840)3.38182125
19Orchitis (HP:0100796)3.36197276
20Increased mean platelet volume (HP:0011877)3.35253987
21Progressive macrocephaly (HP:0004481)3.28038411
22Neuroendocrine neoplasm (HP:0100634)3.24874266
23Atonic seizures (HP:0010819)3.23184951
24Hepatocellular necrosis (HP:0001404)3.18269395
25Hypothermia (HP:0002045)3.15854044
26Encephalitis (HP:0002383)3.13033965
27Recurrent gram-negative bacterial infections (HP:0005420)3.03321710
28Pheochromocytoma (HP:0002666)3.02166100
29Gastrointestinal infarctions (HP:0005244)2.94205621
30Febrile seizures (HP:0002373)2.92548027
31Panhypogammaglobulinemia (HP:0003139)2.90829376
32Mediastinal lymphadenopathy (HP:0100721)2.89872535
33Epileptic encephalopathy (HP:0200134)2.88132486
34Increased CSF lactate (HP:0002490)2.80377649
35Spontaneous hematomas (HP:0007420)2.80097663
36Limb dystonia (HP:0002451)2.74835974
37Episodic fever (HP:0001954)2.73867682
38Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.73703443
39Amyotrophic lateral sclerosis (HP:0007354)2.66283340
40Chronic otitis media (HP:0000389)2.66018251
41Supranuclear gaze palsy (HP:0000605)2.65227317
42Vasculitis (HP:0002633)2.65035900
43Visual hallucinations (HP:0002367)2.64644013
44IgM deficiency (HP:0002850)2.63679208
45Cerebral hypomyelination (HP:0006808)2.62844126
46Hypochromic anemia (HP:0001931)2.62018714
47T lymphocytopenia (HP:0005403)2.61414747
48Recurrent skin infections (HP:0001581)2.59595273
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.58001223
50Severe combined immunodeficiency (HP:0004430)2.50784355
51Failure to thrive in infancy (HP:0001531)2.50074413
52Menstrual irregularities (HP:0000858)2.49519592
533-Methylglutaconic aciduria (HP:0003535)2.49343659
54Acute encephalopathy (HP:0006846)2.48860164
55Abnormality of T cell number (HP:0011839)2.48637203
56Chronic mucocutaneous candidiasis (HP:0002728)2.46402532
57Recurrent cutaneous fungal infections (HP:0011370)2.46402532
58Agitation (HP:0000713)2.45063994
59Keratoconjunctivitis (HP:0001096)2.43640331
60Peripheral hypomyelination (HP:0007182)2.43287756
61Recurrent abscess formation (HP:0002722)2.42639779
62IgG deficiency (HP:0004315)2.42391881
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.41855042
64B lymphocytopenia (HP:0010976)2.40876542
65Abnormality of B cell number (HP:0010975)2.40876542
66Mutism (HP:0002300)2.40511206
67Keratoconjunctivitis sicca (HP:0001097)2.39540248
68Urticaria (HP:0001025)2.35192760
69Hemiplegia (HP:0002301)2.32799192
70Agammaglobulinemia (HP:0004432)2.30425423
71Thyroiditis (HP:0100646)2.29082748
72Abnormality of glycolysis (HP:0004366)2.27480898
73Increased serum pyruvate (HP:0003542)2.27480898
74Leukodystrophy (HP:0002415)2.25609780
75Nasal polyposis (HP:0100582)2.25302477
76Hepatic necrosis (HP:0002605)2.24904035
77Leukocytosis (HP:0001974)2.24106016
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.23791649
79Decreased activity of mitochondrial respiratory chain (HP:0008972)2.23791649
80Petechiae (HP:0000967)2.23643806
81Abnormal platelet function (HP:0011869)2.23479811
82Impaired platelet aggregation (HP:0003540)2.23479811
83Focal seizures (HP:0007359)2.23080533
84Microcytic anemia (HP:0001935)2.22630511
85Increased IgE level (HP:0003212)2.22607840
86Recurrent bronchitis (HP:0002837)2.20081754
87Polyphagia (HP:0002591)2.19527446
88Medial flaring of the eyebrow (HP:0010747)2.18597665
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17810316
90Poor suck (HP:0002033)2.15174979
91Elevated erythrocyte sedimentation rate (HP:0003565)2.14656790
92Combined immunodeficiency (HP:0005387)2.14057191
93Meningitis (HP:0001287)2.12498961
94Chest pain (HP:0100749)2.09843127
95Papilledema (HP:0001085)2.09785734
96Emotional lability (HP:0000712)2.07992972
97Gait imbalance (HP:0002141)2.06476244
98Gingivitis (HP:0000230)2.05785615
99Progressive inability to walk (HP:0002505)2.05657130
100Spastic gait (HP:0002064)2.04489745
101Inflammation of the large intestine (HP:0002037)2.04481815
102Ventricular fibrillation (HP:0001663)2.04467130
103Metaphyseal cupping (HP:0003021)2.03142280
104Abnormality of T cells (HP:0002843)2.02848419
105Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02276016
106Nephrogenic diabetes insipidus (HP:0009806)2.01596832
107Exercise intolerance (HP:0003546)1.99900234
108Obstructive lung disease (HP:0006536)1.99171831
109Chronic obstructive pulmonary disease (HP:0006510)1.99171831
110Absence seizures (HP:0002121)1.99155956
111Delusions (HP:0000746)1.97731824
112Congenital primary aphakia (HP:0007707)1.95537663
113Postural instability (HP:0002172)1.95359404
114Optic disc pallor (HP:0000543)1.95210296
115Verrucae (HP:0200043)1.92883984
116Papilloma (HP:0012740)1.92883984
117Akinesia (HP:0002304)1.92105655
118Chronic sinusitis (HP:0011109)1.91345687
119Gastrointestinal inflammation (HP:0004386)1.91141605
120Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90148269
121Ankle clonus (HP:0011448)1.89618562
122Stomatitis (HP:0010280)1.88861391
123Increased IgM level (HP:0003496)1.88556545
124Vertigo (HP:0002321)1.87416415
125Granulocytopenia (HP:0001913)1.87395568
126Increased serum lactate (HP:0002151)1.86466660
127Toxemia of pregnancy (HP:0100603)1.85747257
128Hypergammaglobulinemia (HP:0010702)1.84179887
129Oligomenorrhea (HP:0000876)1.83830592
130Hemoptysis (HP:0002105)1.83719198
131Abnormal delayed hypersensitivity skin test (HP:0002963)1.82863155
132Neuronal loss in central nervous system (HP:0002529)1.82524680
133Pulmonary embolism (HP:0002204)1.81699765
134Growth hormone excess (HP:0000845)1.81584796
135Autoamputation (HP:0001218)1.81371472
136Sepsis (HP:0100806)1.81213195
137Inability to walk (HP:0002540)1.80919056
138Lactic acidosis (HP:0003128)1.80124965
139Cellulitis (HP:0100658)1.80074883
140Abnormal eating behavior (HP:0100738)1.79638623
141Recurrent fungal infections (HP:0002841)1.79343211
142Aplastic anemia (HP:0001915)1.79210175
143Recurrent bacterial skin infections (HP:0005406)1.78611498
144Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78272233
145Respiratory failure (HP:0002878)1.77849649
146Dialeptic seizures (HP:0011146)1.77660891
147Anxiety (HP:0000739)1.76254324
148Eczematoid dermatitis (HP:0000976)1.75241035
149Pulmonary infiltrates (HP:0002113)1.74873572
150Striae distensae (HP:0001065)1.74799342
151Eosinophilia (HP:0001880)1.74241292
152Progressive cerebellar ataxia (HP:0002073)1.74087530
153Increased hepatocellular lipid droplets (HP:0006565)1.73585991
154Abnormality of eosinophils (HP:0001879)1.73403694
155Cutaneous photosensitivity (HP:0000992)1.73163202
156Anorexia (HP:0002039)1.73032379
157Purpura (HP:0000979)1.72618090
158Spinal canal stenosis (HP:0003416)1.72283395
159Hyperthyroidism (HP:0000836)1.71327672
160Poikilocytosis (HP:0004447)1.71112458
161Microvesicular hepatic steatosis (HP:0001414)1.68869219
162Generalized tonic-clonic seizures (HP:0002069)1.68187645
163Sensory axonal neuropathy (HP:0003390)1.67717183
164Esotropia (HP:0000565)1.67681705
165Recurrent viral infections (HP:0004429)1.66966068
166Abnormal autonomic nervous system physiology (HP:0012332)1.66134737
167Renal Fanconi syndrome (HP:0001994)1.65787645
168Myotonia (HP:0002486)1.65289477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.82240247
2CAMKK23.10315435
3CCNB13.10152827
4CASK2.70433915
5TXK2.70401887
6SIK32.56458867
7TESK22.48352950
8MARK12.40065444
9BUB12.27938348
10LIMK12.14432691
11CDK192.07515366
12MAP4K12.07017491
13RIPK41.98042896
14MAP2K71.91400653
15GRK51.85952006
16STK161.82659062
17ARAF1.80733238
18CSK1.77712340
19TAOK11.68756145
20TESK11.66005419
21GRK61.65455830
22PRPF4B1.61198627
23DAPK11.58907655
24MINK11.54038383
25MAP2K31.50671840
26MARK21.50349802
27TAOK31.49456243
28SYK1.47431946
29VRK11.46402607
30NTRK31.36864807
31TSSK61.32967848
32UHMK11.31230482
33EPHB11.29779494
34MAPKAPK51.29035514
35TNK21.28344806
36FGR1.27896641
37DYRK21.26096131
38ADRBK21.24757470
39MYLK1.21365520
40NTRK21.18508167
41ZAP701.17947635
42IRAK41.17791873
43MAPK121.06504588
44GRK71.05610045
45DYRK1B1.04805962
46TEC1.04521387
47MAP2K41.04363944
48CAMKK11.02108840
49PAK61.01669719
50TLK11.00211432
51CDK181.00089197
52PLK20.99989106
53NTRK10.98937228
54NME10.97543637
55ERN10.96441005
56MAPK130.93430856
57BRSK10.92284302
58PDK10.92053765
59MAP3K130.92021855
60CSF1R0.91984364
61CDK140.90355938
62FYN0.89797160
63CDK150.88548983
64BMPR20.87708100
65BTK0.86560939
66CDK11A0.86069781
67MAP3K40.85646971
68MARK30.85003254
69JAK20.84627318
70EPHA40.83644127
71PAK30.80051247
72CLK10.79975629
73TAOK20.79351049
74NEK10.78511878
75PRKD20.78399496
76MAP3K30.77053104
77DYRK1A0.76834753
78BRAF0.76177301
79LCK0.75427840
80FES0.75392897
81SGK30.74457778
82MST40.73362421
83ITK0.72339081
84PKN10.72174798
85IRAK20.72022389
86STK110.71867919
87MAP3K10.71420654
88SGK20.71259288
89TYRO30.70792545
90MUSK0.70768768
91PRKCQ0.70732107
92EIF2AK10.70296282
93MAP3K90.69711881
94PRKCZ0.69163837
95PINK10.69052456
96PTK2B0.67639493
97PDPK10.67333729
98DAPK20.67209700
99CSNK1G30.66900628
100CAMK10.65983285
101IKBKB0.64876311
102MAP3K60.64566456
103PIM20.64427846
104WEE10.63305167
105ADRBK10.62457229
106CDC70.62162138
107CAMK2B0.60456092
108CDK50.59921589
109PLK30.58530720
110BMX0.58037439
111STK240.58021635
112SIK20.57862045
113AURKA0.57119350
114NME20.56486765
115JAK10.56439917
116PRKCG0.56056861
117PRKD30.55962040
118EPHA30.55305994
119KSR10.54549471
120MAP3K50.54347492
121DAPK30.53204160
122RET0.53022483
123IKBKE0.52344923
124TBK10.51745029
125CAMK1D0.51046066
126LYN0.49804457
127MAP2K60.49694687
128BCR0.49619542
129BLK0.48656673
130MAP3K110.48390916
131SGK2230.47514213
132SGK4940.47514213
133TYK20.46585068
134ACVR1B0.46542167
135CSNK1G20.44361793
136KSR20.43863265
137MAPK40.42583310
138ILK0.42469248
139MAPKAPK30.40977222
140CAMK2A0.40956449
141KIT0.40866486
142MATK0.39542093
143RAF10.39424594
144ROCK20.37852973
145PRKCH0.37469757
146STK40.37282391
147JAK30.36744863
148CAMK40.36692624
149KDR0.36524944
150HCK0.34705634

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.18152229
2Parkinsons disease_Homo sapiens_hsa050122.87051223
3Proteasome_Homo sapiens_hsa030502.70402410
4Synaptic vesicle cycle_Homo sapiens_hsa047212.69566864
5Collecting duct acid secretion_Homo sapiens_hsa049662.53507326
6Primary immunodeficiency_Homo sapiens_hsa053402.31987793
7Alzheimers disease_Homo sapiens_hsa050102.13734798
8Osteoclast differentiation_Homo sapiens_hsa043802.03105999
9Huntingtons disease_Homo sapiens_hsa050161.99610077
10Olfactory transduction_Homo sapiens_hsa047401.80270956
11Nicotine addiction_Homo sapiens_hsa050331.65663873
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51040946
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50991388
14Vibrio cholerae infection_Homo sapiens_hsa051101.49799716
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41260472
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37765972
17Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.35181634
18Morphine addiction_Homo sapiens_hsa050321.34836167
19Long-term potentiation_Homo sapiens_hsa047201.34454395
20DNA replication_Homo sapiens_hsa030301.32930949
21Staphylococcus aureus infection_Homo sapiens_hsa051501.31415232
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31171234
23Dopaminergic synapse_Homo sapiens_hsa047281.30496081
24Cardiac muscle contraction_Homo sapiens_hsa042601.29312978
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26781923
26Ribosome_Homo sapiens_hsa030101.25384828
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23494130
28Circadian entrainment_Homo sapiens_hsa047131.22973668
29Amphetamine addiction_Homo sapiens_hsa050311.22880067
30Rheumatoid arthritis_Homo sapiens_hsa053231.19857805
31Oocyte meiosis_Homo sapiens_hsa041141.17788713
32Serotonergic synapse_Homo sapiens_hsa047261.15848848
33Alcoholism_Homo sapiens_hsa050341.12221402
34Malaria_Homo sapiens_hsa051441.11127658
35T cell receptor signaling pathway_Homo sapiens_hsa046601.10615310
36Mismatch repair_Homo sapiens_hsa034301.10342140
37GABAergic synapse_Homo sapiens_hsa047271.10126482
38RNA polymerase_Homo sapiens_hsa030201.09002451
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07534185
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05186632
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03467914
42Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02617915
43Taste transduction_Homo sapiens_hsa047421.02173183
44Cholinergic synapse_Homo sapiens_hsa047251.01468180
45Acute myeloid leukemia_Homo sapiens_hsa052211.00263276
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.97924373
47Nucleotide excision repair_Homo sapiens_hsa034200.96921406
48Hematopoietic cell lineage_Homo sapiens_hsa046400.96250799
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95564522
50Regulation of autophagy_Homo sapiens_hsa041400.94056306
51Viral myocarditis_Homo sapiens_hsa054160.92941821
52Glutamatergic synapse_Homo sapiens_hsa047240.92546208
53VEGF signaling pathway_Homo sapiens_hsa043700.92227178
54Phagosome_Homo sapiens_hsa041450.91647868
55Base excision repair_Homo sapiens_hsa034100.91267840
56Shigellosis_Homo sapiens_hsa051310.90913078
57Non-small cell lung cancer_Homo sapiens_hsa052230.89900707
58Allograft rejection_Homo sapiens_hsa053300.89001604
59Salivary secretion_Homo sapiens_hsa049700.87701040
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.87102693
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86600684
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86184082
63Homologous recombination_Homo sapiens_hsa034400.86097293
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84943651
65Protein export_Homo sapiens_hsa030600.84875728
66GnRH signaling pathway_Homo sapiens_hsa049120.84742874
67Chemokine signaling pathway_Homo sapiens_hsa040620.83316720
68* Cell cycle_Homo sapiens_hsa041100.83314168
69Graft-versus-host disease_Homo sapiens_hsa053320.80666484
70Type II diabetes mellitus_Homo sapiens_hsa049300.80584739
71Renal cell carcinoma_Homo sapiens_hsa052110.78630133
72Ras signaling pathway_Homo sapiens_hsa040140.77557472
73Antigen processing and presentation_Homo sapiens_hsa046120.76833808
74Rap1 signaling pathway_Homo sapiens_hsa040150.76088863
75Epstein-Barr virus infection_Homo sapiens_hsa051690.75990963
76Long-term depression_Homo sapiens_hsa047300.75189656
77ErbB signaling pathway_Homo sapiens_hsa040120.74828254
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74728523
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74640500
80Leishmaniasis_Homo sapiens_hsa051400.74295801
81Oxytocin signaling pathway_Homo sapiens_hsa049210.73986833
82Choline metabolism in cancer_Homo sapiens_hsa052310.73849666
83Axon guidance_Homo sapiens_hsa043600.73659158
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.72590661
85B cell receptor signaling pathway_Homo sapiens_hsa046620.72028174
86cAMP signaling pathway_Homo sapiens_hsa040240.71947714
87Measles_Homo sapiens_hsa051620.71703437
88Salmonella infection_Homo sapiens_hsa051320.71636623
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.71562762
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.70528784
91Insulin secretion_Homo sapiens_hsa049110.69863753
92Type I diabetes mellitus_Homo sapiens_hsa049400.69707631
93Cocaine addiction_Homo sapiens_hsa050300.69570387
94Pyrimidine metabolism_Homo sapiens_hsa002400.69481067
95Non-homologous end-joining_Homo sapiens_hsa034500.69381438
96Spliceosome_Homo sapiens_hsa030400.67733811
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67625683
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67525392
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67225859
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.66909784
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66320000
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65533985
103African trypanosomiasis_Homo sapiens_hsa051430.65183228
104Asthma_Homo sapiens_hsa053100.64787926
105Autoimmune thyroid disease_Homo sapiens_hsa053200.63039309
106Toxoplasmosis_Homo sapiens_hsa051450.62243698
107Gap junction_Homo sapiens_hsa045400.61717091
108Gastric acid secretion_Homo sapiens_hsa049710.61545815
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61540298
110Purine metabolism_Homo sapiens_hsa002300.61167227
111Endometrial cancer_Homo sapiens_hsa052130.60728950
112Calcium signaling pathway_Homo sapiens_hsa040200.60394772
113Pancreatic cancer_Homo sapiens_hsa052120.58998066
114Dorso-ventral axis formation_Homo sapiens_hsa043200.58295351
115Fanconi anemia pathway_Homo sapiens_hsa034600.58123441
116Basal transcription factors_Homo sapiens_hsa030220.57305321
117Renin secretion_Homo sapiens_hsa049240.57037423
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56522590
119Endocytosis_Homo sapiens_hsa041440.54809611
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54305110
121RNA degradation_Homo sapiens_hsa030180.51297915
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51093786
123Platelet activation_Homo sapiens_hsa046110.50697607
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.48360463
125Systemic lupus erythematosus_Homo sapiens_hsa053220.47098584
126Phototransduction_Homo sapiens_hsa047440.46011764
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45880726
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45345389
129Hepatitis B_Homo sapiens_hsa051610.43963251
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42462107
131Tuberculosis_Homo sapiens_hsa051520.41569063
132MAPK signaling pathway_Homo sapiens_hsa040100.41211408
133Pertussis_Homo sapiens_hsa051330.41184766
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39448676

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