CDNF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)5.50146964
2actin-myosin filament sliding (GO:0033275)5.50146964
3positive regulation of gamma-delta T cell activation (GO:0046645)5.35981382
4regulation of skeletal muscle contraction (GO:0014819)5.22103806
5positive regulation of natural killer cell differentiation (GO:0032825)5.14653113
6sarcoplasmic reticulum calcium ion transport (GO:0070296)5.08583056
7skeletal muscle contraction (GO:0003009)5.05150723
8valine metabolic process (GO:0006573)4.92822492
9actin-mediated cell contraction (GO:0070252)4.74382785
10response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.53193738
11creatine metabolic process (GO:0006600)4.38499728
12regulation of relaxation of muscle (GO:1901077)4.27833106
13regulation of glucokinase activity (GO:0033131)4.26445800
14regulation of hexokinase activity (GO:1903299)4.26445800
15regulation of cell communication by electrical coupling (GO:0010649)4.25193494
16superoxide anion generation (GO:0042554)4.14609120
17negative regulation of erythrocyte differentiation (GO:0045647)4.14197052
18sarcomere organization (GO:0045214)4.13447297
19myofibril assembly (GO:0030239)4.10946635
20piRNA metabolic process (GO:0034587)4.01071352
21behavioral response to nicotine (GO:0035095)3.95708603
22regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.89691767
23regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.89160755
24skeletal muscle fiber development (GO:0048741)3.81715402
25ubiquinone biosynthetic process (GO:0006744)3.80262808
26detection of other organism (GO:0098543)3.78178141
27positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.72736090
28negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.71683609
29energy homeostasis (GO:0097009)3.71247969
30establishment of protein localization to Golgi (GO:0072600)3.69515867
31detection of molecule of bacterial origin (GO:0032490)3.67847962
32myoblast migration (GO:0051451)3.67330921
33myotube cell development (GO:0014904)3.66907880
34protein targeting to Golgi (GO:0000042)3.64631391
35positive regulation of mitochondrial fission (GO:0090141)3.64369816
36negative regulation of myeloid cell apoptotic process (GO:0033033)3.62438080
37cellular ketone body metabolic process (GO:0046950)3.57732527
38skeletal muscle adaptation (GO:0043501)3.57653409
39response to pheromone (GO:0019236)3.55303588
40positive regulation of cellular amide metabolic process (GO:0034250)3.53762245
41retrograde transport, vesicle recycling within Golgi (GO:0000301)3.53607174
42protein localization to Golgi apparatus (GO:0034067)3.52417202
43pyrimidine ribonucleoside catabolic process (GO:0046133)3.52040112
44regulation of natural killer cell differentiation (GO:0032823)3.50190613
45short-chain fatty acid metabolic process (GO:0046459)3.47941090
46ubiquinone metabolic process (GO:0006743)3.47472006
47DNA methylation involved in gamete generation (GO:0043046)3.46846957
48regulation of gamma-delta T cell activation (GO:0046643)3.45830368
49regulation of acyl-CoA biosynthetic process (GO:0050812)3.43763947
50response to muscle activity (GO:0014850)3.43248424
51axoneme assembly (GO:0035082)3.42261906
52striated muscle contraction (GO:0006941)3.38757988
53actin filament-based movement (GO:0030048)3.38448196
54regulation of cilium movement (GO:0003352)3.34950733
55detection of bacterium (GO:0016045)3.34339460
56muscle organ morphogenesis (GO:0048644)3.32553135
57glucan biosynthetic process (GO:0009250)3.31453722
58glycogen biosynthetic process (GO:0005978)3.31453722
59macroautophagy (GO:0016236)3.31305663
60glycogen catabolic process (GO:0005980)3.29218174
61epithelial cilium movement (GO:0003351)3.28847729
62succinate metabolic process (GO:0006105)3.28369323
63regulation of chemokine biosynthetic process (GO:0045073)3.21593339
64quinone biosynthetic process (GO:1901663)3.20354745
65mitochondrial calcium ion homeostasis (GO:0051560)3.20010447
66male meiosis I (GO:0007141)3.15372398
67axonemal dynein complex assembly (GO:0070286)3.14105631
68response to inactivity (GO:0014854)3.11957632
69aspartate family amino acid catabolic process (GO:0009068)3.10426901
70heart process (GO:0003015)3.10257179
71heart contraction (GO:0060047)3.10257179
72dopamine transport (GO:0015872)3.08631993
73regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07693003
74ketone body metabolic process (GO:1902224)3.06917446
75positive regulation of protein homodimerization activity (GO:0090073)3.05632679
76negative regulation of cAMP-mediated signaling (GO:0043951)3.05070339
77positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.04294011
78neuromuscular synaptic transmission (GO:0007274)3.02630815
79motile cilium assembly (GO:0044458)2.99324056
80glucan catabolic process (GO:0009251)2.96008341
81detection of external biotic stimulus (GO:0098581)2.95822676
82dendritic cell chemotaxis (GO:0002407)2.95391827
83regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.94261809
84negative regulation of muscle hypertrophy (GO:0014741)2.93402506
85cilium movement (GO:0003341)2.92558441
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.92313046
87protein polyglutamylation (GO:0018095)2.91149156
88otic vesicle formation (GO:0030916)2.91053399
89epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90924147
90regulation of sequestering of triglyceride (GO:0010889)2.89924536
91regulation of action potential (GO:0098900)2.89038738
92regulation of cofactor metabolic process (GO:0051193)2.88621729
93regulation of coenzyme metabolic process (GO:0051196)2.88621729
94muscle atrophy (GO:0014889)2.88126122
95regulation of actin filament-based movement (GO:1903115)2.87197246
96sperm motility (GO:0030317)2.86071090
97positive regulation by symbiont of host defense response (GO:0052509)2.84592148
98modulation by symbiont of host defense response (GO:0052031)2.84592148
99modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84592148
100modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84592148
101positive regulation by organism of defense response of other organism involved in symbiotic interact2.84592148
102modulation by symbiont of host immune response (GO:0052553)2.84592148
103regulation of chromatin silencing (GO:0031935)2.84568292
104adenosine metabolic process (GO:0046085)2.84039306
105Peyers patch development (GO:0048541)2.83128027
106mucosal-associated lymphoid tissue development (GO:0048537)2.83128027
107L-fucose catabolic process (GO:0042355)2.82816063
108fucose catabolic process (GO:0019317)2.82816063
109L-fucose metabolic process (GO:0042354)2.82816063
110protein complex biogenesis (GO:0070271)2.82364762
111antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82260638
112cilium or flagellum-dependent cell motility (GO:0001539)2.82220998
113cardiac myofibril assembly (GO:0055003)2.82100900
114respiratory chain complex IV assembly (GO:0008535)2.81414220
115response to peptidoglycan (GO:0032494)2.81296698
116mitochondrial respiratory chain complex assembly (GO:0033108)2.80444873
117mitochondrial respiratory chain complex I assembly (GO:0032981)2.78107562
118NADH dehydrogenase complex assembly (GO:0010257)2.78107562
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78107562
120cellular response to gamma radiation (GO:0071480)2.78100863
121synapsis (GO:0007129)2.76991124
122branched-chain amino acid catabolic process (GO:0009083)2.76800258
123exogenous drug catabolic process (GO:0042738)2.76788616
124regulation of sarcomere organization (GO:0060297)2.76008989
125skeletal muscle tissue regeneration (GO:0043403)2.75125474
126positive regulation of B cell differentiation (GO:0045579)2.74865912
127negative regulation of mast cell activation (GO:0033004)2.73400112
128cellular polysaccharide catabolic process (GO:0044247)2.70036203
129regulation of gonadotropin secretion (GO:0032276)2.69958787
130DNA synthesis involved in DNA repair (GO:0000731)2.69026625
131replication fork processing (GO:0031297)2.67826282
132actomyosin structure organization (GO:0031032)2.67262422
133negative regulation of chemokine production (GO:0032682)2.66784421
134drug catabolic process (GO:0042737)2.66097238
135intraciliary transport (GO:0042073)2.65874091
136muscle system process (GO:0003012)2.62400654
137cytidine metabolic process (GO:0046087)2.62238147
138cytidine catabolic process (GO:0006216)2.62238147
139cytidine deamination (GO:0009972)2.62238147
140synaptic transmission, cholinergic (GO:0007271)2.61761253
141skeletal muscle tissue development (GO:0007519)2.61529326
142muscle fiber development (GO:0048747)2.61288401
143negative regulation of organelle assembly (GO:1902116)2.60034504
144striated muscle atrophy (GO:0014891)2.58259834
145regulation of striated muscle contraction (GO:0006942)2.58094011
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57654112
147male meiosis (GO:0007140)2.57465790
148positive regulation of antigen processing and presentation (GO:0002579)2.57422975
149oxaloacetate metabolic process (GO:0006107)2.55238575
150peptidyl-threonine dephosphorylation (GO:0035970)2.54622761
151protein K6-linked ubiquitination (GO:0085020)2.53038520
152negative regulation of cardiac muscle hypertrophy (GO:0010614)2.52977469
153regulation of gamma-delta T cell differentiation (GO:0045586)2.51844101
154cytochrome complex assembly (GO:0017004)2.51787468
155detection of biotic stimulus (GO:0009595)2.51655052
156regulation of myoblast differentiation (GO:0045661)2.51265019
157meiotic chromosome segregation (GO:0045132)2.51130663
158carnitine transport (GO:0015879)2.51104958
159amino-acid betaine transport (GO:0015838)2.51104958
160cardiac muscle contraction (GO:0060048)2.51002448
161regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.50345729
162polysaccharide catabolic process (GO:0000272)2.48272743
163neuronal action potential propagation (GO:0019227)2.46234772
164cullin deneddylation (GO:0010388)2.45985494
165cardiac chamber formation (GO:0003207)2.45254119
166muscle contraction (GO:0006936)2.44981643
167muscle adaptation (GO:0043500)2.42983884
168cardiac muscle hypertrophy (GO:0003300)2.41860729
169bundle of His cell to Purkinje myocyte communication (GO:0086069)2.41312257
170response to host immune response (GO:0052572)2.41162893
171response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.41162893
172import into cell (GO:0098657)2.40033054
173dendritic cell migration (GO:0036336)2.39689587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.92097909
2GATA1_22025678_ChIP-Seq_K562_Human4.27789740
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.68383709
4PCGF2_27294783_Chip-Seq_ESCs_Mouse2.90094287
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.89783656
6GBX2_23144817_ChIP-Seq_PC3_Human2.78770634
7ZNF274_21170338_ChIP-Seq_K562_Hela2.66816711
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.41747636
9SUZ12_27294783_Chip-Seq_NPCs_Mouse2.41291705
10PCGF2_27294783_Chip-Seq_NPCs_Mouse2.40326659
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.39438197
12IGF1R_20145208_ChIP-Seq_DFB_Human2.36688068
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.26475298
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25628519
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23495762
16NFE2_27457419_Chip-Seq_LIVER_Mouse2.18570734
17EZH2_27294783_Chip-Seq_NPCs_Mouse2.10215097
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03490698
19EZH2_22144423_ChIP-Seq_EOC_Human2.02335851
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.97053025
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95281950
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91100385
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86320941
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81577406
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76077113
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.75255938
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72107800
28CBP_20019798_ChIP-Seq_JUKART_Human1.71412059
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71412059
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69466091
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.69018543
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.65357097
33SCL_19346495_ChIP-Seq_HPC-7_Human1.65050690
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.64457043
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63300666
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62580352
37SUZ12_18555785_Chip-Seq_ESCs_Mouse1.62408133
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61967136
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59328859
40ZFX_18555785_Chip-Seq_ESCs_Mouse1.58056967
41* STAT3_18555785_Chip-Seq_ESCs_Mouse1.57801951
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57728931
43* E2F1_18555785_Chip-Seq_ESCs_Mouse1.57493256
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55998146
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54700107
46KLF5_20875108_ChIP-Seq_MESCs_Mouse1.52740153
47* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51368501
48* P53_22387025_ChIP-Seq_ESCs_Mouse1.50775974
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.50414737
50TP53_22573176_ChIP-Seq_HFKS_Human1.49345183
51NMYC_18555785_Chip-Seq_ESCs_Mouse1.46686901
52SOX2_19829295_ChIP-Seq_ESCs_Human1.45363443
53NANOG_19829295_ChIP-Seq_ESCs_Human1.45363443
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.44356486
55P300_18555785_Chip-Seq_ESCs_Mouse1.44040165
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43967463
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43967463
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.43814138
59* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42377854
60OCT4_21477851_ChIP-Seq_ESCs_Mouse1.41583615
61BCAT_22108803_ChIP-Seq_LS180_Human1.41210700
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.40839529
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40180137
64* NANOG_18555785_Chip-Seq_ESCs_Mouse1.37074641
65CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.36249992
66* SOX2_18555785_Chip-Seq_ESCs_Mouse1.35825284
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35429138
68* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35349649
69* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34950387
70OCT4_18555785_Chip-Seq_ESCs_Mouse1.34362624
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31391697
72STAT3_23295773_ChIP-Seq_U87_Human1.31165545
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30768313
74IRF8_27001747_Chip-Seq_BMDM_Mouse1.30563786
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.30105405
76P300_19829295_ChIP-Seq_ESCs_Human1.29924172
77PHF8_20622853_ChIP-Seq_HELA_Human1.29800418
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.29175135
79* PU1_27457419_Chip-Seq_LIVER_Mouse1.28979247
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28479394
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28418195
82ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28278847
83* MYC_19829295_ChIP-Seq_ESCs_Human1.28149002
84ER_23166858_ChIP-Seq_MCF-7_Human1.28030691
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28021034
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27441815
87NCOR_22424771_ChIP-Seq_293T_Human1.27092563
88CTCF_18555785_Chip-Seq_ESCs_Mouse1.26089890
89TCF4_23295773_ChIP-Seq_U87_Human1.25042470
90* CMYC_18555785_Chip-Seq_ESCs_Mouse1.22865049
91STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22088102
92AR_21572438_ChIP-Seq_LNCaP_Human1.21956921
93ETV1_20927104_ChIP-Seq_GIST48_Human1.20796334
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20486629
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.19857561
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19653987
97JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19612176
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19571294
99RBPJ_21746931_ChIP-Seq_IB4_Human1.19262860
100AR_25329375_ChIP-Seq_VCAP_Human1.19067425
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18631357
102* GATA6_21074721_ChIP-Seq_CACO-2_Human1.18036630
103PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16555344
104EED_16625203_ChIP-ChIP_MESCs_Mouse1.16407106
105SMAD4_21799915_ChIP-Seq_A2780_Human1.16280265
106KLF4_18555785_Chip-Seq_ESCs_Mouse1.16171269
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15918328
108OCT4_20526341_ChIP-Seq_ESCs_Human1.15410760
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15240779
110FOXA1_25329375_ChIP-Seq_VCAP_Human1.15240779
111AR_20517297_ChIP-Seq_VCAP_Human1.15096332
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14977605
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14607050
114TBL1_22424771_ChIP-Seq_293T_Human1.14230551
115VDR_22108803_ChIP-Seq_LS180_Human1.14206399
116CBX2_22325352_ChIP-Seq_293T-Rex_Human1.13356001
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13067025
118SMAD1_18555785_Chip-Seq_ESCs_Mouse1.12926822
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12447116
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12131678
121NFYB_21822215_ChIP-Seq_K562_Human1.11707666
122FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11689670
123GATA3_21878914_ChIP-Seq_MCF-7_Human1.11536269
124SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11397821
125CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.11111585
126PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.10799119
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10659341
128NANOG_20526341_ChIP-Seq_ESCs_Human1.10498138
129HOXB7_26014856_ChIP-Seq_BT474_Human1.10024574
130HNFA_21074721_ChIP-Seq_CACO-2_Human1.09705986
131BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09320646
132SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09275829
133* TCF4_22108803_ChIP-Seq_LS180_Human1.09184642
134EZH2_27304074_Chip-Seq_ESCs_Mouse1.09119276
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08948679
136PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08232174
137LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08205147
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07911566
139SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07899167
140* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07787291
141CDX2_22108803_ChIP-Seq_LS180_Human1.07629038
142STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07618493
143VDR_24787735_ChIP-Seq_THP-1_Human1.05098806
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04135734
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03802257
146VDR_23849224_ChIP-Seq_CD4+_Human1.03773676
147SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03769936
148EP300_21415370_ChIP-Seq_HL-1_Mouse1.03760553
149RUNX_20019798_ChIP-Seq_JUKART_Human1.03202063
150CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00613187
151FUS_26573619_Chip-Seq_HEK293_Human0.99680965
152EWS_26573619_Chip-Seq_HEK293_Human0.99504373
153SRF_21415370_ChIP-Seq_HL-1_Mouse0.99119839
154* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98908765
155TAF15_26573619_Chip-Seq_HEK293_Human0.96409055
156SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94830602
157PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94392658
158IRF1_19129219_ChIP-ChIP_H3396_Human0.94309283
159TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94231339
160FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93688680
161EZH2_27294783_Chip-Seq_ESCs_Mouse0.91208161
162MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90989871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.56516658
2MP0000749_muscle_degeneration4.12845206
3MP0000751_myopathy3.73042445
4MP0002837_dystrophic_cardiac_calcinosis3.29896664
5MP0004145_abnormal_muscle_electrophysio3.15009023
6MP0004484_altered_response_of2.80194057
7MP0004036_abnormal_muscle_relaxation2.78396980
8MP0000013_abnormal_adipose_tissue2.51478560
9MP0001188_hyperpigmentation2.47840167
10MP0002106_abnormal_muscle_physiology2.39944165
11MP0008877_abnormal_DNA_methylation2.29950945
12MP0004084_abnormal_cardiac_muscle2.28292572
13MP0003828_pulmonary_edema2.24356556
14MP0004510_myositis2.21401583
15MP0004215_abnormal_myocardial_fiber2.15839296
16MP0005620_abnormal_muscle_contractility2.13769216
17MP0001986_abnormal_taste_sensitivity2.09343499
18MP0004130_abnormal_muscle_cell2.05965130
19MP0005369_muscle_phenotype2.02992350
20MP0000759_abnormal_skeletal_muscle1.94792996
21MP0001984_abnormal_olfaction1.94097126
22MP0006292_abnormal_olfactory_placode1.91042544
23MP0008775_abnormal_heart_ventricle1.88036444
24MP0002254_reproductive_system_inflammat1.87129664
25MP0001835_abnormal_antigen_presentation1.87117405
26MP0002148_abnormal_hypersensitivity_rea1.84073364
27MP0004043_abnormal_pH_regulation1.82926562
28MP0004087_abnormal_muscle_fiber1.78141891
29MP0002277_abnormal_respiratory_mucosa1.74370942
30MP0009785_altered_susceptibility_to1.72513268
31MP0005330_cardiomyopathy1.71551817
32MP0005551_abnormal_eye_electrophysiolog1.70439523
33MP0008875_abnormal_xenobiotic_pharmacok1.70247844
34MP0002972_abnormal_cardiac_muscle1.65039737
35MP0000569_abnormal_digit_pigmentation1.60963756
36MP0003724_increased_susceptibility_to1.55555734
37MP0002653_abnormal_ependyma_morphology1.54879707
38MP0003950_abnormal_plasma_membrane1.54845522
39MP0009764_decreased_sensitivity_to1.54252252
40MP0000343_altered_response_to1.52976984
41MP0000750_abnormal_muscle_regeneration1.52548867
42MP0001853_heart_inflammation1.49056565
43MP0005670_abnormal_white_adipose1.48203785
44MP0000747_muscle_weakness1.44820514
45MP0004142_abnormal_muscle_tone1.40666452
46MP0003137_abnormal_impulse_conducting1.39840904
47MP0001501_abnormal_sleep_pattern1.39313341
48MP0004147_increased_porphyrin_level1.37394564
49MP0003787_abnormal_imprinting1.36849800
50MP0003011_delayed_dark_adaptation1.35307620
51MP0002269_muscular_atrophy1.35233499
52MP0002163_abnormal_gland_morphology1.35106422
53MP0002876_abnormal_thyroid_physiology1.31801079
54MP0005410_abnormal_fertilization1.30565071
55MP0003195_calcinosis1.29640590
56MP0005332_abnormal_amino_acid1.29510341
57MP0000015_abnormal_ear_pigmentation1.27007013
58MP0008789_abnormal_olfactory_epithelium1.26782471
59MP0002638_abnormal_pupillary_reflex1.26553881
60MP0006072_abnormal_retinal_apoptosis1.26497028
61MP0001485_abnormal_pinna_reflex1.25783873
62MP0001544_abnormal_cardiovascular_syste1.25326981
63MP0005385_cardiovascular_system_phenoty1.25326981
64MP0002419_abnormal_innate_immunity1.25059024
65MP0000003_abnormal_adipose_tissue1.23773336
66MP0000566_synostosis1.23454643
67MP0002272_abnormal_nervous_system1.23037561
68MP0005645_abnormal_hypothalamus_physiol1.20965816
69MP0000383_abnormal_hair_follicle1.20500910
70MP0005266_abnormal_metabolism1.17518198
71MP0003698_abnormal_male_reproductive1.16995287
72MP0005387_immune_system_phenotype1.16982451
73MP0001790_abnormal_immune_system1.16982451
74MP0002102_abnormal_ear_morphology1.16912822
75MP0009780_abnormal_chondrocyte_physiolo1.16251283
76MP0005025_abnormal_response_to1.15991939
77MP0001764_abnormal_homeostasis1.15878098
78MP0006036_abnormal_mitochondrial_physio1.14119434
79MP0005253_abnormal_eye_physiology1.14077004
80MP0008872_abnormal_physiological_respon1.12596761
81MP0002234_abnormal_pharynx_morphology1.11086339
82MP0004233_abnormal_muscle_weight1.07636332
83MP0005646_abnormal_pituitary_gland1.07129880
84MP0005671_abnormal_response_to1.03750855
85MP0004270_analgesia1.01820603
86MP0010630_abnormal_cardiac_muscle1.00907651
87MP0009745_abnormal_behavioral_response0.99981773
88MP0001929_abnormal_gametogenesis0.99452201
89MP0002132_abnormal_respiratory_system0.97655442
90MP0005666_abnormal_adipose_tissue0.96873253
91MP0004185_abnormal_adipocyte_glucose0.95704988
92MP0004885_abnormal_endolymph0.95456854
93MP0006138_congestive_heart_failure0.95216633
94MP0005165_increased_susceptibility_to0.94962614
95MP0002452_abnormal_antigen_presenting0.93834140
96MP0001529_abnormal_vocalization0.92886077
97MP0000427_abnormal_hair_cycle0.92716963
98MP0002160_abnormal_reproductive_system0.92705775
99MP0006276_abnormal_autonomic_nervous0.91839641
100MP0002332_abnormal_exercise_endurance0.91706554
101MP0005174_abnormal_tail_pigmentation0.91654424
102MP0005000_abnormal_immune_tolerance0.91072087
103MP0005451_abnormal_body_composition0.90849294
104MP0002971_abnormal_brown_adipose0.90344153
105MP0002078_abnormal_glucose_homeostasis0.89487146
106MP0003941_abnormal_skin_development0.89455999
107MP0009333_abnormal_splenocyte_physiolog0.89271020
108MP0005647_abnormal_sex_gland0.85060687
109MP0002723_abnormal_immune_serum0.84652728
110MP0005171_absent_coat_pigmentation0.84264453
111MP0002693_abnormal_pancreas_physiology0.83679124
112MP0001819_abnormal_immune_cell0.83505358
113MP0002938_white_spotting0.83396497
114MP0002138_abnormal_hepatobiliary_system0.83151294
115MP0001800_abnormal_humoral_immune0.82745479
116MP0000372_irregular_coat_pigmentation0.82732719
117MP0002210_abnormal_sex_determination0.82261489
118MP0005379_endocrine/exocrine_gland_phen0.82176688
119MP0003718_maternal_effect0.82040904
120MP0002405_respiratory_system_inflammati0.81893548
121MP0002822_catalepsy0.80831162
122MP0000733_abnormal_muscle_development0.80504162
123MP0000685_abnormal_immune_system0.80286118
124MP0002933_joint_inflammation0.79802158
125MP0002420_abnormal_adaptive_immunity0.79416900
126MP0002108_abnormal_muscle_morphology0.79168144
127MP0004085_abnormal_heartbeat0.79137587
128MP0008058_abnormal_DNA_repair0.79128071
129MP0008260_abnormal_autophagy0.78849230
130MP0005409_darkened_coat_color0.78746410
131MP0002067_abnormal_sensory_capabilities0.77503059
132MP0005334_abnormal_fat_pad0.77219056
133MP0005636_abnormal_mineral_homeostasis0.76631982
134MP0002127_abnormal_cardiovascular_syste0.76321434
135MP0005535_abnormal_body_temperature0.75912218
136MP0000631_abnormal_neuroendocrine_gland0.75892602
137MP0009250_abnormal_appendicular_skeleto0.74129933
138MP0003436_decreased_susceptibility_to0.73922012
139MP0001661_extended_life_span0.73137841
140MP0009046_muscle_twitch0.72663406
141MP0005386_behavior/neurological_phenoty0.71020415
142MP0004924_abnormal_behavior0.71020415
143MP0005389_reproductive_system_phenotype0.70953133
144MP0001905_abnormal_dopamine_level0.70738371
145MP0003136_yellow_coat_color0.70525793
146MP0002557_abnormal_social/conspecific_i0.70349718
147MP0002572_abnormal_emotion/affect_behav0.69907096
148MP0002734_abnormal_mechanical_nocicepti0.68859488
149MP0001765_abnormal_ion_homeostasis0.68728957
150MP0002095_abnormal_skin_pigmentation0.68260765
151MP0008995_early_reproductive_senescence0.65473287
152MP0000230_abnormal_systemic_arterial0.64613934
153MP0000049_abnormal_middle_ear0.64149824
154MP0004381_abnormal_hair_follicle0.62512831
155MP0009697_abnormal_copulation0.61318092
156MP0006035_abnormal_mitochondrial_morpho0.61020872
157MP0000767_abnormal_smooth_muscle0.60123677

Predicted human phenotypes

RankGene SetZ-score
1Muscle hypertrophy of the lower extremities (HP:0008968)5.06443426
2Muscle fiber inclusion bodies (HP:0100299)5.06173414
3Exercise-induced myalgia (HP:0003738)5.05555095
4Calf muscle hypertrophy (HP:0008981)4.96905190
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.83166650
6Exercise-induced muscle cramps (HP:0003710)4.62073819
7Nemaline bodies (HP:0003798)4.47570638
8Ventricular tachycardia (HP:0004756)3.87529898
9Muscle fiber splitting (HP:0003555)3.75330497
10Abnormality of the left ventricular outflow tract (HP:0011103)3.69342921
11Subaortic stenosis (HP:0001682)3.69342921
12Distal lower limb muscle weakness (HP:0009053)3.62799415
13Abnormality of alanine metabolism (HP:0010916)3.59688063
14Hyperalaninemia (HP:0003348)3.59688063
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.59688063
16Abnormal hair whorl (HP:0010721)3.58905825
17Abnormality of the calf musculature (HP:0001430)3.53572250
18Type 1 muscle fiber predominance (HP:0003803)3.45636945
19Sudden death (HP:0001699)3.45235846
20Meningioma (HP:0002858)3.23053658
21Lipoatrophy (HP:0100578)3.14835534
22Atrial fibrillation (HP:0005110)3.13125131
23EMG: myopathic abnormalities (HP:0003458)3.11793503
24Nonprogressive disorder (HP:0003680)3.08026927
25Chromosomal breakage induced by crosslinking agents (HP:0003221)3.06456065
26Type II lissencephaly (HP:0007260)3.00270112
27Myoglobinuria (HP:0002913)2.99780024
28Increased intramyocellular lipid droplets (HP:0012240)2.99400888
29White forelock (HP:0002211)2.97428072
30Renal cortical cysts (HP:0000803)2.93349674
31Prolonged QT interval (HP:0001657)2.90665459
32Nephronophthisis (HP:0000090)2.90597696
33Optic neuritis (HP:0100653)2.86217492
34Retrobulbar optic neuritis (HP:0100654)2.86217492
35Weak cry (HP:0001612)2.85975951
36Fatigable weakness (HP:0003473)2.82809899
37Abnormality of the neuromuscular junction (HP:0003398)2.82809899
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.82765998
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.82765998
40Dilated cardiomyopathy (HP:0001644)2.82424548
41Primary atrial arrhythmia (HP:0001692)2.81833322
42Type 2 muscle fiber atrophy (HP:0003554)2.78372089
43Patchy hypopigmentation of hair (HP:0011365)2.75215657
44Increased muscle lipid content (HP:0009058)2.69631302
45Supraventricular tachycardia (HP:0004755)2.67592539
46Increased connective tissue (HP:0009025)2.65634548
47Recurrent abscess formation (HP:0002722)2.62655486
48Myopathic facies (HP:0002058)2.61697154
49Supraventricular arrhythmia (HP:0005115)2.56420892
50Chromsome breakage (HP:0040012)2.55962878
51Abnormality of midbrain morphology (HP:0002418)2.53534231
52Molar tooth sign on MRI (HP:0002419)2.53534231
53Hyporeflexia of lower limbs (HP:0002600)2.52017750
54Acute necrotizing encephalopathy (HP:0006965)2.50228237
55Abnormal mitochondria in muscle tissue (HP:0008316)2.50078379
56Tubular atrophy (HP:0000092)2.49814085
57Acute encephalopathy (HP:0006846)2.49618683
58Pancreatic cysts (HP:0001737)2.47540584
59Ketoacidosis (HP:0001993)2.46843141
60Distal arthrogryposis (HP:0005684)2.46541213
61Congenital stationary night blindness (HP:0007642)2.44698214
62Hyperglycinuria (HP:0003108)2.41001887
63Myotonia (HP:0002486)2.40717431
64Absent/shortened dynein arms (HP:0200106)2.37610857
65Dynein arm defect of respiratory motile cilia (HP:0012255)2.37610857
66Asymmetric septal hypertrophy (HP:0001670)2.36673229
67Rhabdomyolysis (HP:0003201)2.35132521
68Medial flaring of the eyebrow (HP:0010747)2.34466353
69Malignant hyperthermia (HP:0002047)2.32621220
70Facial diplegia (HP:0001349)2.30434351
71Abnormality of the renal medulla (HP:0100957)2.25522641
72Abnormal respiratory epithelium morphology (HP:0012253)2.24518217
73Abnormal respiratory motile cilium morphology (HP:0005938)2.24518217
74Calcaneovalgus deformity (HP:0001848)2.21772699
75Abnormality of the renal collecting system (HP:0004742)2.21692117
76Progressive macrocephaly (HP:0004481)2.21274700
77Pancreatic fibrosis (HP:0100732)2.19968027
78Hepatocellular necrosis (HP:0001404)2.19857085
79Increased CSF lactate (HP:0002490)2.19669526
80Hepatic necrosis (HP:0002605)2.18582725
81Muscle fiber atrophy (HP:0100295)2.17539971
82Deformed tarsal bones (HP:0008119)2.16435297
83Areflexia of lower limbs (HP:0002522)2.15182784
84Muscle stiffness (HP:0003552)2.14367749
85Exercise intolerance (HP:0003546)2.13987640
86Duplicated collecting system (HP:0000081)2.11996022
87Ketosis (HP:0001946)2.11160138
88Orchitis (HP:0100796)2.09196525
89Large for gestational age (HP:0001520)2.08546448
90Abnormal EKG (HP:0003115)2.08305835
91Aplasia cutis congenita (HP:0001057)2.07886861
92Ragged-red muscle fibers (HP:0003200)2.06248310
93True hermaphroditism (HP:0010459)2.04330635
94Abnormal ciliary motility (HP:0012262)2.03744283
95Difficulty running (HP:0009046)2.03493131
96Mitochondrial inheritance (HP:0001427)2.02329223
97Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00423442
98Bulbar palsy (HP:0001283)1.97010897
99Abnormal finger flexion creases (HP:0006143)1.96603014
100Abnormality of skeletal muscle fiber size (HP:0012084)1.94696436
101Abnormality of incisor morphology (HP:0011063)1.93566407
102Ulnar deviation of the wrist (HP:0003049)1.92458327
103Broad-based gait (HP:0002136)1.92006233
104Left ventricular hypertrophy (HP:0001712)1.91448863
105EMG: neuropathic changes (HP:0003445)1.91027128
106Palpitations (HP:0001962)1.90831098
107Fetal akinesia sequence (HP:0001989)1.90482209
108Chronic hepatic failure (HP:0100626)1.88641253
109Popliteal pterygium (HP:0009756)1.87973467
110Lipid accumulation in hepatocytes (HP:0006561)1.87347382
111Recurrent bacterial skin infections (HP:0005406)1.87291807
112Neck muscle weakness (HP:0000467)1.87002409
113Bundle branch block (HP:0011710)1.85389929
114Right ventricular cardiomyopathy (HP:0011663)1.84975227
115Hypoplastic ischia (HP:0003175)1.84032100
116Abnormality of glycine metabolism (HP:0010895)1.84006577
117Abnormality of serine family amino acid metabolism (HP:0010894)1.84006577
118Syncope (HP:0001279)1.84005493
119Round ear (HP:0100830)1.83983080
120Hyperkalemia (HP:0002153)1.83525281
121Petechiae (HP:0000967)1.82921814
122Abnormal respiratory motile cilium physiology (HP:0012261)1.82189170
123Centrally nucleated skeletal muscle fibers (HP:0003687)1.82147000
124Frequent falls (HP:0002359)1.82070183
125Generalized muscle weakness (HP:0003324)1.81236426
126Gait imbalance (HP:0002141)1.81115747
127Lactic acidosis (HP:0003128)1.80046333
128Hyperinsulinemic hypoglycemia (HP:0000825)1.79687009
129Myositis (HP:0100614)1.78502540
130Prostate neoplasm (HP:0100787)1.77561161
131Gingivitis (HP:0000230)1.77182811
132Abnormality of dental color (HP:0011073)1.76700745
133Distal lower limb amyotrophy (HP:0008944)1.75879988
134Heart block (HP:0012722)1.75623975
135Absent phalangeal crease (HP:0006109)1.74415393
136Congenital primary aphakia (HP:0007707)1.74311390
137Eczematoid dermatitis (HP:0000976)1.74124007
138Attenuation of retinal blood vessels (HP:0007843)1.72913312
139Rhinitis (HP:0012384)1.72743559
140Concave nail (HP:0001598)1.72636886
141Cerebral edema (HP:0002181)1.72425184
1423-Methylglutaconic aciduria (HP:0003535)1.72424367
143Hyperglycinemia (HP:0002154)1.71534819
144Gowers sign (HP:0003391)1.71026246
145Abnormality of the renal cortex (HP:0011035)1.70595400
146Febrile seizures (HP:0002373)1.69387884
147Abnormal atrioventricular conduction (HP:0005150)1.63332771
148Rimmed vacuoles (HP:0003805)1.62247698
149Insulin-resistant diabetes mellitus (HP:0000831)1.61904613
150Keratoconjunctivitis sicca (HP:0001097)1.61192276

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.18069756
2OBSCN3.96376318
3FRK3.40161996
4TTN2.81490090
5TIE12.67095149
6MUSK2.62561294
7NME22.58597977
8IRAK42.57979962
9INSRR2.48135991
10PHKG22.45308619
11PHKG12.45308619
12TXK2.41272873
13JAK32.26422316
14CASK2.15344678
15IRAK32.14951983
16WNK32.06299833
17PINK11.99911013
18BCKDK1.80698128
19PIK3CG1.61882492
20MKNK21.61082831
21BTK1.58703262
22MAP4K21.58590417
23TEC1.58367003
24SIK31.58343109
25MAP3K141.58326378
26GRK71.53572414
27MST1R1.51275906
28PNCK1.50087900
29LIMK11.45127460
30PDK21.31401284
31MST41.26081746
32EIF2AK21.25987028
33EIF2AK31.22797988
34TNIK1.22324080
35ADRBK21.22246152
36MYLK1.21386136
37MAPK121.20106559
38MARK11.18644345
39YES11.16388305
40PIK3CA1.15707201
41TRPM71.15505549
42GRK11.15239971
43CDK191.13092668
44SYK1.10339986
45PAK31.08278158
46DMPK1.08047400
47PDK31.04938928
48PDK41.04938928
49MAP3K121.03854094
50NEK10.98903785
51STK240.98110409
52NEK90.94807347
53IKBKB0.93666659
54STK160.93244254
55DYRK1B0.93080168
56MKNK10.91535915
57BMPR1B0.88630293
58PKN10.87955311
59WNK40.87560894
60TNK20.86794368
61ERBB30.86644367
62NME10.85600821
63STK38L0.85159619
64PIM10.83278549
65MARK30.82220805
66TRIM280.78125486
67CAMK2A0.77041286
68LYN0.76389386
69CDK30.76162389
70JAK10.75538087
71ADRBK10.73478555
72MAP2K30.71571984
73IRAK10.71213674
74VRK10.70932862
75NUAK10.70179049
76CAMK2D0.69526166
77BMPR20.69175357
78SGK20.68551584
79DAPK20.67957505
80PRPF4B0.67611319
81CHUK0.66767155
82IKBKE0.65597062
83MAP3K90.65502500
84AKT30.65352975
85PTK2B0.65083109
86MAP3K50.64661632
87PRKAA20.64193690
88MAPK130.63996353
89STK390.63555639
90NLK0.63408729
91PRKCG0.63389200
92MAP2K40.62914680
93MAP2K70.62154272
94PRKCQ0.61913115
95STK380.60140357
96MAPK110.59582438
97PRKG10.59137589
98EPHA30.59001160
99CAMK40.58162018
100NTRK30.58069923
101CAMK2G0.55791892
102MAP2K60.54764323
103PRKACA0.53292465
104MAP3K70.53127369
105ROCK10.51549307
106PRKG20.51480409
107RPS6KL10.51191611
108RPS6KC10.51191611
109MAP3K40.51189763
110CDK80.50480276
111CLK10.50230377
112PRKCE0.49918706
113BRD40.49754476
114MAPK40.49094290
115RPS6KA60.48736825
116MAPKAPK30.48447700
117PRKACB0.47737389
118KIT0.47678658
119PRKCD0.47431081
120HCK0.47394965
121MAP3K60.44266964
122TAOK20.44246138
123PLK20.43899509
124MAPKAPK50.43441367
125NEK60.43092828
126LMTK20.42914140
127CAMK10.42516279
128PDK10.41651451
129OXSR10.40559376
130PLK40.40449103
131MAPK70.39942588
132TAOK30.39924310
133RPS6KB10.39711660
134STK40.39436085
135AKT20.39414573
136CAMK2B0.37795916
137RPS6KA20.37147011
138CSNK1A10.37057856
139BLK0.36217820
140LCK0.35031904
141SGK10.34226690
142PRKAA10.34143375
143MAPK150.33640238
144PRKCI0.32563088
145TLK10.31959761
146MAP2K10.30893769
147CSNK1G20.30215944
148PLK10.27257616
149RPS6KA30.26653232
150PRKCA0.25757610
151PRKCZ0.25463841
152STK110.25330134
153MOS0.24319211
154UHMK10.23849913
155DYRK20.23667643
156NTRK20.23003662

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.26258738
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.72675682
3Graft-versus-host disease_Homo sapiens_hsa053322.48655230
4Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.48256379
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43765034
6Dilated cardiomyopathy_Homo sapiens_hsa054142.37809106
7Linoleic acid metabolism_Homo sapiens_hsa005912.37523719
8Allograft rejection_Homo sapiens_hsa053302.27665679
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21033333
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18611527
11Cardiac muscle contraction_Homo sapiens_hsa042602.18580077
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.09351561
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.06579381
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.04443986
15Oxidative phosphorylation_Homo sapiens_hsa001902.01169966
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.98194372
17Other glycan degradation_Homo sapiens_hsa005111.88593857
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.85407843
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84909627
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.84714545
21Autoimmune thyroid disease_Homo sapiens_hsa053201.83964841
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82260328
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.81928882
24Leishmaniasis_Homo sapiens_hsa051401.78399986
25Parkinsons disease_Homo sapiens_hsa050121.70614068
26Fanconi anemia pathway_Homo sapiens_hsa034601.64779507
27Measles_Homo sapiens_hsa051621.63768193
28Peroxisome_Homo sapiens_hsa041461.62464008
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58538036
30Alzheimers disease_Homo sapiens_hsa050101.54318049
31Viral myocarditis_Homo sapiens_hsa054161.49577729
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49246512
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47262662
34Nitrogen metabolism_Homo sapiens_hsa009101.44504066
35Tryptophan metabolism_Homo sapiens_hsa003801.44443308
36Rheumatoid arthritis_Homo sapiens_hsa053231.43910701
37Ether lipid metabolism_Homo sapiens_hsa005651.42716209
38Hematopoietic cell lineage_Homo sapiens_hsa046401.39266559
39Fatty acid metabolism_Homo sapiens_hsa012121.38688180
40Arachidonic acid metabolism_Homo sapiens_hsa005901.38616191
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38518550
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38497934
43Asthma_Homo sapiens_hsa053101.30240147
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27849639
45Calcium signaling pathway_Homo sapiens_hsa040201.27786400
46Huntingtons disease_Homo sapiens_hsa050161.26020080
47RNA polymerase_Homo sapiens_hsa030201.22768306
48Primary immunodeficiency_Homo sapiens_hsa053401.21103091
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19690370
50Protein export_Homo sapiens_hsa030601.18779541
51Pyruvate metabolism_Homo sapiens_hsa006201.18467891
52Arginine biosynthesis_Homo sapiens_hsa002201.18231858
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18211694
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.16117065
55Starch and sucrose metabolism_Homo sapiens_hsa005001.14900049
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14825634
57African trypanosomiasis_Homo sapiens_hsa051431.14340223
58beta-Alanine metabolism_Homo sapiens_hsa004101.11069384
59Osteoclast differentiation_Homo sapiens_hsa043801.10513714
60Malaria_Homo sapiens_hsa051441.07995336
61Primary bile acid biosynthesis_Homo sapiens_hsa001201.07082350
62Ovarian steroidogenesis_Homo sapiens_hsa049131.06689256
63Sulfur metabolism_Homo sapiens_hsa009201.06407077
64Olfactory transduction_Homo sapiens_hsa047401.05482666
65Propanoate metabolism_Homo sapiens_hsa006401.05343951
66Caffeine metabolism_Homo sapiens_hsa002321.03047302
67Type I diabetes mellitus_Homo sapiens_hsa049401.00491294
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99239536
69Selenocompound metabolism_Homo sapiens_hsa004500.98854318
70Chemical carcinogenesis_Homo sapiens_hsa052040.98752004
71Fatty acid biosynthesis_Homo sapiens_hsa000610.98259703
72Carbon metabolism_Homo sapiens_hsa012000.97401635
73Phenylalanine metabolism_Homo sapiens_hsa003600.95917270
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95260434
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94987302
76Salmonella infection_Homo sapiens_hsa051320.94880349
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94789255
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93620864
79Circadian rhythm_Homo sapiens_hsa047100.88755732
80Phagosome_Homo sapiens_hsa041450.87457025
81Nicotine addiction_Homo sapiens_hsa050330.87371358
82Metabolic pathways_Homo sapiens_hsa011000.86253382
83Homologous recombination_Homo sapiens_hsa034400.85058095
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83297248
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82711619
86Retinol metabolism_Homo sapiens_hsa008300.81978155
87Fatty acid elongation_Homo sapiens_hsa000620.81315888
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80367674
89Serotonergic synapse_Homo sapiens_hsa047260.79380247
90Staphylococcus aureus infection_Homo sapiens_hsa051500.78723153
91Taste transduction_Homo sapiens_hsa047420.78103931
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76956912
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76829189
94Tuberculosis_Homo sapiens_hsa051520.76276871
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.75964181
96Fat digestion and absorption_Homo sapiens_hsa049750.75561318
97RNA degradation_Homo sapiens_hsa030180.74420718
98Herpes simplex infection_Homo sapiens_hsa051680.73468540
99Legionellosis_Homo sapiens_hsa051340.73280446
100Proteasome_Homo sapiens_hsa030500.72314697
101Influenza A_Homo sapiens_hsa051640.71605585
102Morphine addiction_Homo sapiens_hsa050320.70705291
103Pertussis_Homo sapiens_hsa051330.69553407
104Purine metabolism_Homo sapiens_hsa002300.68310675
105Oxytocin signaling pathway_Homo sapiens_hsa049210.67722983
106TNF signaling pathway_Homo sapiens_hsa046680.67361031
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66519162
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.66170639
109Folate biosynthesis_Homo sapiens_hsa007900.65818317
110Vitamin B6 metabolism_Homo sapiens_hsa007500.63866624
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63852922
112Fatty acid degradation_Homo sapiens_hsa000710.63581776
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61960070
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61587986
115Non-homologous end-joining_Homo sapiens_hsa034500.61206635
116Tyrosine metabolism_Homo sapiens_hsa003500.59571754
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58679189
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.58603639
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58342072
120Basal transcription factors_Homo sapiens_hsa030220.56741748
121Notch signaling pathway_Homo sapiens_hsa043300.52974570
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.52867955
123Histidine metabolism_Homo sapiens_hsa003400.52789721
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.52597631
125Chemokine signaling pathway_Homo sapiens_hsa040620.52312552
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.51835151
127Vitamin digestion and absorption_Homo sapiens_hsa049770.51387975
128Sphingolipid metabolism_Homo sapiens_hsa006000.51324128
129Lysine degradation_Homo sapiens_hsa003100.47489350
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47430893
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.47027427
132Apoptosis_Homo sapiens_hsa042100.46180245
133Regulation of autophagy_Homo sapiens_hsa041400.45676536
134Insulin secretion_Homo sapiens_hsa049110.45550292
135Pentose phosphate pathway_Homo sapiens_hsa000300.45156888
136ABC transporters_Homo sapiens_hsa020100.44455299
137Arginine and proline metabolism_Homo sapiens_hsa003300.44295490
138Inositol phosphate metabolism_Homo sapiens_hsa005620.42454834
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42390413
140Circadian entrainment_Homo sapiens_hsa047130.40381112
141Toxoplasmosis_Homo sapiens_hsa051450.40169617
142Insulin resistance_Homo sapiens_hsa049310.39663890
143Pyrimidine metabolism_Homo sapiens_hsa002400.39409909
144One carbon pool by folate_Homo sapiens_hsa006700.38876335
145Glucagon signaling pathway_Homo sapiens_hsa049220.37693819
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37673572
147Renin secretion_Homo sapiens_hsa049240.37167795
148p53 signaling pathway_Homo sapiens_hsa041150.37102022
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36236660
150PPAR signaling pathway_Homo sapiens_hsa033200.35722323
151Prolactin signaling pathway_Homo sapiens_hsa049170.35467441
152Amphetamine addiction_Homo sapiens_hsa050310.35021381
153GABAergic synapse_Homo sapiens_hsa047270.34695747
154Glutathione metabolism_Homo sapiens_hsa004800.33962444
155Acute myeloid leukemia_Homo sapiens_hsa052210.32866846
156FoxO signaling pathway_Homo sapiens_hsa040680.32735137
157Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32734802
158Platelet activation_Homo sapiens_hsa046110.31409195
159Phototransduction_Homo sapiens_hsa047440.31282928

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