CDO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.23691201
2L-phenylalanine catabolic process (GO:0006559)7.23691201
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.91608234
4L-phenylalanine metabolic process (GO:0006558)6.91608234
5aromatic amino acid family catabolic process (GO:0009074)6.41975682
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.11079797
7tryptophan catabolic process (GO:0006569)5.70038424
8indole-containing compound catabolic process (GO:0042436)5.70038424
9indolalkylamine catabolic process (GO:0046218)5.70038424
10alpha-linolenic acid metabolic process (GO:0036109)5.67704966
11kynurenine metabolic process (GO:0070189)5.60886038
12bile acid biosynthetic process (GO:0006699)5.55179295
13urea metabolic process (GO:0019627)5.47263736
14urea cycle (GO:0000050)5.47263736
15glyoxylate metabolic process (GO:0046487)5.40452448
16complement activation, alternative pathway (GO:0006957)5.37713000
17tryptophan metabolic process (GO:0006568)5.37099975
18negative regulation of fibrinolysis (GO:0051918)5.23763942
19high-density lipoprotein particle remodeling (GO:0034375)5.23409634
20* sulfur amino acid catabolic process (GO:0000098)5.22443069
21pyrimidine nucleobase catabolic process (GO:0006208)5.15420646
22regulation of protein activation cascade (GO:2000257)5.05996978
23nitrogen cycle metabolic process (GO:0071941)5.04428479
24protein carboxylation (GO:0018214)5.03551970
25peptidyl-glutamic acid carboxylation (GO:0017187)5.03551970
26regulation of fibrinolysis (GO:0051917)5.00509275
27* cysteine metabolic process (GO:0006534)4.93822514
28regulation of triglyceride catabolic process (GO:0010896)4.91690366
29presynaptic membrane assembly (GO:0097105)4.90701868
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88179737
31bile acid metabolic process (GO:0008206)4.80438134
32regulation of complement activation (GO:0030449)4.75839746
33homocysteine metabolic process (GO:0050667)4.69070614
34lysine catabolic process (GO:0006554)4.67509522
35lysine metabolic process (GO:0006553)4.67509522
36acylglycerol homeostasis (GO:0055090)4.65513131
37triglyceride homeostasis (GO:0070328)4.65513131
38aromatic amino acid family metabolic process (GO:0009072)4.64650508
39tyrosine metabolic process (GO:0006570)4.63445376
40* serine family amino acid catabolic process (GO:0009071)4.60979345
41reverse cholesterol transport (GO:0043691)4.60333226
42amino-acid betaine metabolic process (GO:0006577)4.57678508
43presynaptic membrane organization (GO:0097090)4.57383034
44regulation of cholesterol esterification (GO:0010872)4.56369749
45sequestering of actin monomers (GO:0042989)4.54625890
46plasma lipoprotein particle clearance (GO:0034381)4.53166784
47plasma lipoprotein particle remodeling (GO:0034369)4.52329827
48protein-lipid complex remodeling (GO:0034368)4.52329827
49macromolecular complex remodeling (GO:0034367)4.52329827
50* alpha-amino acid catabolic process (GO:1901606)4.43535662
51cellular ketone body metabolic process (GO:0046950)4.30300821
52phospholipid efflux (GO:0033700)4.28182937
53negative regulation of sterol transport (GO:0032372)4.24185387
54negative regulation of cholesterol transport (GO:0032375)4.24185387
55* cellular amino acid catabolic process (GO:0009063)4.16587988
56ethanol oxidation (GO:0006069)4.11955560
57coenzyme catabolic process (GO:0009109)4.11198907
58cholesterol biosynthetic process (GO:0006695)4.07539776
59nucleobase catabolic process (GO:0046113)4.06535822
60bile acid and bile salt transport (GO:0015721)4.06089926
61glutamate metabolic process (GO:0006536)4.05794100
62postsynaptic membrane organization (GO:0001941)4.04710368
63glycine metabolic process (GO:0006544)4.02054787
64indolalkylamine metabolic process (GO:0006586)4.01485108
65acetyl-CoA metabolic process (GO:0006084)4.00138812
66cellular modified amino acid catabolic process (GO:0042219)3.97558176
67positive regulation of lipid catabolic process (GO:0050996)3.95466544
68cellular glucuronidation (GO:0052695)3.94829812
69cholesterol efflux (GO:0033344)3.92485597
70amine catabolic process (GO:0009310)3.90605220
71cellular biogenic amine catabolic process (GO:0042402)3.90605220
72negative regulation of lipase activity (GO:0060192)3.90165944
73benzene-containing compound metabolic process (GO:0042537)3.89682414
74auditory behavior (GO:0031223)3.89215777
75imidazole-containing compound metabolic process (GO:0052803)3.87894991
76positive regulation of fatty acid beta-oxidation (GO:0032000)3.86517882
77short-chain fatty acid metabolic process (GO:0046459)3.84870614
78valine metabolic process (GO:0006573)3.79815031
79* serine family amino acid metabolic process (GO:0009069)3.79570497
80arginine metabolic process (GO:0006525)3.79062175
81fibrinolysis (GO:0042730)3.76407432
82* organic acid catabolic process (GO:0016054)3.75543082
83* carboxylic acid catabolic process (GO:0046395)3.75543082
84serine family amino acid biosynthetic process (GO:0009070)3.74194523
85fatty acid beta-oxidation (GO:0006635)3.73987055
86nonmotile primary cilium assembly (GO:0035058)3.73401752
87plasma lipoprotein particle assembly (GO:0034377)3.73196708
88epithelial cilium movement (GO:0003351)3.73110378
89drug catabolic process (GO:0042737)3.72338130
90intraciliary transport (GO:0042073)3.72293492
91phospholipid homeostasis (GO:0055091)3.72154609
92neuron cell-cell adhesion (GO:0007158)3.71853918
93fatty acid oxidation (GO:0019395)3.71728492
94ketone body metabolic process (GO:1902224)3.71604827
95dicarboxylic acid biosynthetic process (GO:0043650)3.71332374
96retinal ganglion cell axon guidance (GO:0031290)3.70944980
97neuronal stem cell maintenance (GO:0097150)3.70132259
98regulation of development, heterochronic (GO:0040034)3.68594031
99neuron fate determination (GO:0048664)3.68531272
100low-density lipoprotein particle remodeling (GO:0034374)3.67645695
1012-oxoglutarate metabolic process (GO:0006103)3.67423874
102aldehyde catabolic process (GO:0046185)3.65920241
103epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.65225389
104lipid oxidation (GO:0034440)3.64592172
105monocarboxylic acid catabolic process (GO:0072329)3.63595599
106negative regulation of oligodendrocyte differentiation (GO:0048715)3.63240588
107complement activation (GO:0006956)3.62793812
108sterol biosynthetic process (GO:0016126)3.61668377
109positive regulation of triglyceride lipase activity (GO:0061365)3.61589500
110positive regulation of lipoprotein lipase activity (GO:0051006)3.61589500
111regulation of timing of cell differentiation (GO:0048505)3.60373763
112response to auditory stimulus (GO:0010996)3.58446050
113fatty acid catabolic process (GO:0009062)3.58018200
114cholesterol homeostasis (GO:0042632)3.57998929
115cytolysis (GO:0019835)3.57818193
116complement activation, classical pathway (GO:0006958)3.56852052
117sterol homeostasis (GO:0055092)3.52769925
118regulation of cholesterol homeostasis (GO:2000188)3.52684065
119limb bud formation (GO:0060174)3.51511740
120uronic acid metabolic process (GO:0006063)3.50860301
121glucuronate metabolic process (GO:0019585)3.50860301
122protein activation cascade (GO:0072376)3.50799805
123L-serine metabolic process (GO:0006563)3.46432494
124cellular response to cholesterol (GO:0071397)3.45890563
125cilium movement (GO:0003341)3.30463218
126negative regulation of astrocyte differentiation (GO:0048712)3.22916817
127negative regulation of axon guidance (GO:1902668)3.16883826
128isoprenoid biosynthetic process (GO:0008299)3.15450761
129cilium morphogenesis (GO:0060271)3.12972241
130mechanosensory behavior (GO:0007638)3.09840784
131calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.08595600
132carnitine metabolic process (GO:0009437)3.06132720
133negative regulation of glial cell differentiation (GO:0045686)3.04162377
134axonal fasciculation (GO:0007413)3.03231761
135vocalization behavior (GO:0071625)3.01887552
136transmission of nerve impulse (GO:0019226)2.96248082
137positive regulation of mitochondrial fission (GO:0090141)2.94898282
138otic vesicle formation (GO:0030916)2.94421754
139forebrain neuron differentiation (GO:0021879)2.91167013
140cilium assembly (GO:0042384)2.87903110
141neuron recognition (GO:0008038)2.87225503
142midbrain development (GO:0030901)2.86972197
143protein localization to cilium (GO:0061512)2.86346646
144axonemal dynein complex assembly (GO:0070286)2.85378631
145cilium organization (GO:0044782)2.84995381
146neuron projection extension involved in neuron projection guidance (GO:1902284)2.84026521
147axon extension involved in axon guidance (GO:0048846)2.84026521
148positive regulation of synapse assembly (GO:0051965)2.83146340
149cellular response to sterol (GO:0036315)2.81251033
150somite development (GO:0061053)2.80425889
151cell proliferation in forebrain (GO:0021846)2.78448941
152neurotransmitter-gated ion channel clustering (GO:0072578)2.74511386
153smoothened signaling pathway (GO:0007224)2.71955553
154regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71719636
155C4-dicarboxylate transport (GO:0015740)2.69265946
156behavioral response to nicotine (GO:0035095)2.68828211
157vascular smooth muscle contraction (GO:0014829)2.63943691
158dendritic spine morphogenesis (GO:0060997)2.61567169
159regulation of cilium movement (GO:0003352)2.60848200
160cilium or flagellum-dependent cell motility (GO:0001539)2.60349075
161lens fiber cell development (GO:0070307)2.59739435
162regulation of oligodendrocyte differentiation (GO:0048713)2.59232876
163retinal rod cell development (GO:0046548)2.58937782
164lateral sprouting from an epithelium (GO:0060601)2.58653415
165radial glial cell differentiation (GO:0060019)2.56210138
166synapse assembly (GO:0007416)2.55495735
167regulation of neurotransmitter uptake (GO:0051580)2.55353269
168water-soluble vitamin biosynthetic process (GO:0042364)2.55187031
169exogenous drug catabolic process (GO:0042738)2.54350307
170gamma-aminobutyric acid transport (GO:0015812)2.54261520
171establishment of mitochondrion localization (GO:0051654)2.53350952
172olfactory bulb development (GO:0021772)2.52962593
173cellular response to leptin stimulus (GO:0044320)2.52856109
174regulation of respiratory system process (GO:0044065)2.49939107
175central nervous system projection neuron axonogenesis (GO:0021952)2.49842576
176axon ensheathment in central nervous system (GO:0032291)2.48215353
177central nervous system myelination (GO:0022010)2.48215353
178positive regulation of oligodendrocyte differentiation (GO:0048714)2.45870299
179protein localization to synapse (GO:0035418)2.42848455
180neurotransmitter catabolic process (GO:0042135)2.41232028
181platelet dense granule organization (GO:0060155)2.40697204
182negative regulation of transcription regulatory region DNA binding (GO:2000678)2.40389664
183protein polyglutamylation (GO:0018095)2.40171969
184positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.39921379
185mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.39632067
186tongue development (GO:0043586)2.37695356
187axoneme assembly (GO:0035082)2.35903788
188substrate-independent telencephalic tangential migration (GO:0021826)2.35043838
189substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.35043838
190spinal cord development (GO:0021510)2.34873145
191positive regulation of amino acid transport (GO:0051957)2.34569804
192peroxisome organization (GO:0007031)2.34470222
193prepulse inhibition (GO:0060134)2.33619781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.99630443
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.84393736
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.50169184
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.36306150
5* LXR_22158963_ChIP-Seq_LIVER_Mouse6.25875828
6EZH2_22144423_ChIP-Seq_EOC_Human5.30786800
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.05636495
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.66366896
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.96407771
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.58835224
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.35727214
12GBX2_23144817_ChIP-Seq_PC3_Human3.00397865
13IGF1R_20145208_ChIP-Seq_DFB_Human2.79207076
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.72917857
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59848738
16ZNF274_21170338_ChIP-Seq_K562_Hela2.55614132
17TAF15_26573619_Chip-Seq_HEK293_Human2.50260434
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49563322
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.35768693
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32295670
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29196970
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28219111
23CLOCK_20551151_ChIP-Seq_293T_Human2.18430358
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.16757154
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07062390
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01744917
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00894079
28TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.00878759
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2937741
30P300_19829295_ChIP-Seq_ESCs_Human1.95593790
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90962239
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87496860
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.87210198
34EWS_26573619_Chip-Seq_HEK293_Human1.81882610
35FUS_26573619_Chip-Seq_HEK293_Human1.80126253
36RNF2_27304074_Chip-Seq_NSC_Mouse1.80108022
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79321472
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75277748
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.73523063
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70459291
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67309048
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.62159726
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58098888
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57305295
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57163782
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54849425
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54727090
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50220310
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47771054
50REST_21632747_ChIP-Seq_MESCs_Mouse1.47034938
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46962128
52SMAD4_21799915_ChIP-Seq_A2780_Human1.46157773
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45842330
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45661150
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41494183
56VDR_22108803_ChIP-Seq_LS180_Human1.41469608
57CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39950895
58GATA1_22025678_ChIP-Seq_K562_Human1.38260589
59HNF4A_19822575_ChIP-Seq_HepG2_Human1.36035873
60* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35235972
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35190194
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34535536
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.34371171
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34234077
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33987850
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33179431
67HTT_18923047_ChIP-ChIP_STHdh_Human1.32768774
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.32018715
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31678771
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31678771
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31530430
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.30241179
73AR_25329375_ChIP-Seq_VCAP_Human1.28342654
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27616176
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26537752
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25514505
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25064886
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.24352504
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23100091
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21240105
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21130430
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21130430
83AR_21572438_ChIP-Seq_LNCaP_Human1.20960429
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20120733
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19061378
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18397540
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.16159970
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15984627
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15736319
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15216461
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15137313
92STAT3_23295773_ChIP-Seq_U87_Human1.14775447
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13713227
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.13556253
95TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13389710
96TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13072764
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.12648828
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12281542
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12120621
100CBP_20019798_ChIP-Seq_JUKART_Human1.12120621
101ER_23166858_ChIP-Seq_MCF-7_Human1.12014963
102IRF1_19129219_ChIP-ChIP_H3396_Human1.11300864
103* RUNX2_22187159_ChIP-Seq_PCA_Human1.09477648
104RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08288189
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07712625
106TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07652683
107PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04434430
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02465083
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02100975
110SOX9_26525672_Chip-Seq_HEART_Mouse1.01807578
111SALL1_21062744_ChIP-ChIP_HESCs_Human1.01140896
112* SOX2_21211035_ChIP-Seq_LN229_Gbm1.00708442
113SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00158287
114SOX2_16153702_ChIP-ChIP_HESCs_Human0.99201588
115KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98996022
116P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98125218
117SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97973661
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97959406
119TCF4_22108803_ChIP-Seq_LS180_Human0.97792251
120LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97532974
121ZNF263_19887448_ChIP-Seq_K562_Human0.97459941
122JUN_21703547_ChIP-Seq_K562_Human0.97403315
123P53_22387025_ChIP-Seq_ESCs_Mouse0.96319767
124IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95603771
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95377725
126TP53_18474530_ChIP-ChIP_U2OS_Human0.94766418
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.93583912
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92970735
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92316497
130GATA4_25053715_ChIP-Seq_YYC3_Human0.88361824
131ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88345147
132TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87816778
133* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85495500
134AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83102573
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77649267
136SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76882812
137SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76063846
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76021734
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76021734
140Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75783908
141KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74985171
142NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.70515080
143PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.69181784
144ESR1_21235772_ChIP-Seq_MCF-7_Human0.67010790
145ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.66567983
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.66179286
147RARA_24833708_ChIP-Seq_LIVER_Mouse0.64198295
148RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63195388
149FOXO3_23340844_ChIP-Seq_DLD1_Human0.63146934
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.61162271
151FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60909962
152SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60331838
153IRF8_22096565_ChIP-ChIP_GC-B_Human0.60175750
154NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58725928
155FOXA1_25552417_ChIP-Seq_VCAP_Human0.58582967
156RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.58252830
157CEBPB_22108803_ChIP-Seq_LS180_Human0.58006150
158BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57993523
159PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.57843315
160RARB_24833708_ChIP-Seq_LIVER_Mouse0.56985183
161LXR_22292898_ChIP-Seq_THP-1_Human0.53688566
162TRIM28_21343339_ChIP-Seq_HEK293_Human0.53316131
163BCAT_22108803_ChIP-Seq_LS180_Human0.53072694
164PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.52653824
165ERG_21242973_ChIP-ChIP_JURKAT_Human0.51812288
166PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51581589
167CDX2_20551321_ChIP-Seq_CACO-2_Human0.50833584
168TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.50588110
169SOX2_20726797_ChIP-Seq_SW620_Human0.49275874
170FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49216755
171CBP_21632823_ChIP-Seq_H3396_Human0.49138569
172MYC_19915707_ChIP-ChIP_AK7_Human0.48369473
173AR_20517297_ChIP-Seq_VCAP_Human0.47636031
174ESET_19884257_ChIP-Seq_ESCs_Mouse0.47633471
175STAT1_17558387_ChIP-Seq_HELA_Human0.47384633
176STAT3_1855785_ChIP-Seq_MESCs_Mouse0.46915917
177FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46079182
178GATA3_24758297_ChIP-Seq_MCF-7_Human0.45441315
179P53_21459846_ChIP-Seq_SAOS-2_Human0.43613852
180EGR1_19032775_ChIP-ChIP_M12_Human0.43498107
181NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.42729944
182GATA6_25053715_ChIP-Seq_YYC3_Human0.42664637
183GATA2_19941826_ChIP-Seq_K562_Human0.42610502
184GATA1_19941826_ChIP-Seq_K562_Human0.41381772
185SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41161410
186STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.41036252
187GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.40917374
188ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.40700400
189TBX20_22328084_ChIP-Seq_HEART_Mouse0.39998467
190TBX20_22080862_ChIP-Seq_HEART_Mouse0.39998467
191EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.39809740
192PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.38399498
193CDX2_22108803_ChIP-Seq_LS180_Human0.38292758
194ERG_20517297_ChIP-Seq_VCAP_Human0.38286090
195PIAS1_25552417_ChIP-Seq_VCAP_Human0.37875039
196* MYC_27129775_Chip-Seq_CORNEA_Mouse0.36968023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.00420274
2MP0005360_urolithiasis7.25987385
3MP0005365_abnormal_bile_salt6.04756626
4MP0005085_abnormal_gallbladder_physiolo5.98371889
5MP0008875_abnormal_xenobiotic_pharmacok4.89807735
6MP0003136_yellow_coat_color4.70905832
7MP0003806_abnormal_nucleotide_metabolis3.82612640
8MP0010329_abnormal_lipoprotein_level3.79870798
9MP0003252_abnormal_bile_duct3.68041383
10MP0003880_abnormal_central_pattern3.66361803
11MP0000566_synostosis3.27553675
12MP0009840_abnormal_foam_cell3.03843780
13MP0001529_abnormal_vocalization2.99341945
14MP0002822_catalepsy2.98073097
15MP0005332_abnormal_amino_acid2.80385394
16MP0005083_abnormal_biliary_tract2.66941256
17MP0003195_calcinosis2.61358767
18MP0002653_abnormal_ependyma_morphology2.58182387
19MP0000778_abnormal_nervous_system2.52914591
20MP0003191_abnormal_cellular_cholesterol2.50373543
21MP0001666_abnormal_nutrient_absorption2.47639407
22MP0001984_abnormal_olfaction2.31984651
23MP0002118_abnormal_lipid_homeostasis2.27244542
24MP0000609_abnormal_liver_physiology2.22505272
25MP0002638_abnormal_pupillary_reflex2.14305667
26MP0004019_abnormal_vitamin_homeostasis2.12033974
27MP0005171_absent_coat_pigmentation1.98456048
28MP0006292_abnormal_olfactory_placode1.98225314
29MP0008789_abnormal_olfactory_epithelium1.94338258
30MP0005670_abnormal_white_adipose1.94281181
31MP0003122_maternal_imprinting1.92929140
32MP0005319_abnormal_enzyme/_coenzyme1.85246622
33MP0002138_abnormal_hepatobiliary_system1.83186392
34MP0010030_abnormal_orbit_morphology1.82186294
35MP0005394_taste/olfaction_phenotype1.76986979
36MP0005499_abnormal_olfactory_system1.76986979
37MP0005423_abnormal_somatic_nervous1.76103688
38MP0006276_abnormal_autonomic_nervous1.73458872
39MP0002282_abnormal_trachea_morphology1.73170898
40MP0003868_abnormal_feces_composition1.69563877
41MP0001764_abnormal_homeostasis1.66228684
42MP0004859_abnormal_synaptic_plasticity1.64890257
43MP0001486_abnormal_startle_reflex1.63359223
44MP0005584_abnormal_enzyme/coenzyme_acti1.62147959
45MP0004133_heterotaxia1.61171172
46MP0002234_abnormal_pharynx_morphology1.59383528
47MP0000026_abnormal_inner_ear1.55769214
48MP0005551_abnormal_eye_electrophysiolog1.54586860
49MP0002938_white_spotting1.54073663
50MP0004142_abnormal_muscle_tone1.50286112
51MP0004270_analgesia1.47659211
52MP0002102_abnormal_ear_morphology1.46839713
53MP0005253_abnormal_eye_physiology1.45876107
54MP0002572_abnormal_emotion/affect_behav1.45251457
55MP0005187_abnormal_penis_morphology1.43581247
56MP0003705_abnormal_hypodermis_morpholog1.43501208
57MP0000631_abnormal_neuroendocrine_gland1.43314582
58MP0003186_abnormal_redox_activity1.41537627
59MP0001293_anophthalmia1.39946868
60MP0009745_abnormal_behavioral_response1.39797568
61MP0005451_abnormal_body_composition1.36708510
62MP0004130_abnormal_muscle_cell1.36637956
63MP0003011_delayed_dark_adaptation1.35932687
64MP0006072_abnormal_retinal_apoptosis1.35514515
65MP0009643_abnormal_urine_homeostasis1.34355152
66MP0009697_abnormal_copulation1.32955729
67MP0002063_abnormal_learning/memory/cond1.31984990
68MP0003635_abnormal_synaptic_transmissio1.31450717
69MP0004885_abnormal_endolymph1.29647901
70MP0002064_seizures1.25119225
71MP0000955_abnormal_spinal_cord1.23719692
72MP0005666_abnormal_adipose_tissue1.22808630
73MP0002249_abnormal_larynx_morphology1.22255224
74MP0002557_abnormal_social/conspecific_i1.21893767
75MP0002876_abnormal_thyroid_physiology1.21856745
76MP0000049_abnormal_middle_ear1.21525083
77MP0002254_reproductive_system_inflammat1.18669534
78MP0002971_abnormal_brown_adipose1.17861273
79MP0002751_abnormal_autonomic_nervous1.16287892
80MP0002736_abnormal_nociception_after1.15418597
81MP0000598_abnormal_liver_morphology1.15315938
82MP0003938_abnormal_ear_development1.13534202
83MP0005647_abnormal_sex_gland1.13530474
84MP0003656_abnormal_erythrocyte_physiolo1.11401036
85MP0002272_abnormal_nervous_system1.09717558
86MP0002067_abnormal_sensory_capabilities1.09312770
87MP0001485_abnormal_pinna_reflex1.09077595
88MP0002233_abnormal_nose_morphology1.08688985
89MP0003283_abnormal_digestive_organ1.08227195
90MP0000604_amyloidosis1.07369166
91MP0005391_vision/eye_phenotype1.06535813
92MP0001968_abnormal_touch/_nociception1.05966354
93MP0005195_abnormal_posterior_eye1.04487332
94MP0002734_abnormal_mechanical_nocicepti1.03509928
95MP0009764_decreased_sensitivity_to1.03091438
96MP0003121_genomic_imprinting1.02608949
97MP0002752_abnormal_somatic_nervous1.01683346
98MP0001963_abnormal_hearing_physiology1.01638228
99MP0003937_abnormal_limbs/digits/tail_de1.01398419
100MP0005334_abnormal_fat_pad1.01373843
101MP0001324_abnormal_eye_pigmentation0.99689693
102MP0001286_abnormal_eye_development0.99548945
103MP0009763_increased_sensitivity_to0.98043702
104MP0000569_abnormal_digit_pigmentation0.97650011
105MP0002882_abnormal_neuron_morphology0.97612708
106MP0000647_abnormal_sebaceous_gland0.96078843
107MP0001661_extended_life_span0.95871802
108MP0005636_abnormal_mineral_homeostasis0.94479088
109MP0002837_dystrophic_cardiac_calcinosis0.92599769
110MP0002078_abnormal_glucose_homeostasis0.92579735
111MP0003755_abnormal_palate_morphology0.92528031
112MP0002152_abnormal_brain_morphology0.92287240
113MP0005535_abnormal_body_temperature0.92256261
114MP0010368_abnormal_lymphatic_system0.91086551
115MP0004742_abnormal_vestibular_system0.90331158
116MP0000537_abnormal_urethra_morphology0.88941267
117MP0006036_abnormal_mitochondrial_physio0.88500115
118MP0001905_abnormal_dopamine_level0.88382980
119MP0002735_abnormal_chemical_nociception0.87796667
120MP0002909_abnormal_adrenal_gland0.87359228
121MP0009642_abnormal_blood_homeostasis0.86488887
122MP0009046_muscle_twitch0.86342777
123MP0005386_behavior/neurological_phenoty0.86062772
124MP0004924_abnormal_behavior0.86062772
125MP0002184_abnormal_innervation0.85943990
126MP0003119_abnormal_digestive_system0.85700830
127MP0004185_abnormal_adipocyte_glucose0.85213077
128MP0002697_abnormal_eye_size0.84976328
129MP0002092_abnormal_eye_morphology0.84545311
130MP0001970_abnormal_pain_threshold0.83054709
131MP0000372_irregular_coat_pigmentation0.81654247
132MP0003861_abnormal_nervous_system0.81619248
133MP0003690_abnormal_glial_cell0.81327387
134MP0008469_abnormal_protein_level0.81027061
135MP0003890_abnormal_embryonic-extraembry0.80833865
136MP0001756_abnormal_urination0.80254826
137MP0005376_homeostasis/metabolism_phenot0.80025405
138MP0001346_abnormal_lacrimal_gland0.79970020
139MP0001177_atelectasis0.79920188
140MP0001502_abnormal_circadian_rhythm0.79890840
141MP0005646_abnormal_pituitary_gland0.78831056
142MP0005408_hypopigmentation0.75090728
143MP0005448_abnormal_energy_balance0.72229054
144MP0009115_abnormal_fat_cell0.72217393
145MP0009765_abnormal_xenobiotic_induced0.70736685
146MP0005220_abnormal_exocrine_pancreas0.69421285
147MP0005084_abnormal_gallbladder_morpholo0.66385128
148MP0005375_adipose_tissue_phenotype0.65499475
149MP0003329_amyloid_beta_deposits0.64647400
150MP0009053_abnormal_anal_canal0.62621059
151MP0002970_abnormal_white_adipose0.60848965
152MP0000639_abnormal_adrenal_gland0.60116125
153MP0005266_abnormal_metabolism0.59295641
154MP0008438_abnormal_cutaneous_collagen0.57816645
155MP0001881_abnormal_mammary_gland0.54637526
156MP0003724_increased_susceptibility_to0.54339984
157MP0002136_abnormal_kidney_physiology0.53165669
158MP0005395_other_phenotype0.52988147
159MP0003953_abnormal_hormone_level0.51574280
160MP0005248_abnormal_Harderian_gland0.47862182
161MP0002796_impaired_skin_barrier0.46339522
162MP0002168_other_aberrant_phenotype0.45089221
163MP0003638_abnormal_response/metabolism_0.45052237
164MP0003959_abnormal_lean_body0.45045468
165MP0004782_abnormal_surfactant_physiolog0.44715016
166MP0008874_decreased_physiological_sensi0.43738324
167MP0005164_abnormal_response_to0.43555847
168MP0006035_abnormal_mitochondrial_morpho0.43426557
169MP0000230_abnormal_systemic_arterial0.42481732
170MP0009672_abnormal_birth_weight0.41176202
171MP0002060_abnormal_skin_morphology0.40419372
172MP0008872_abnormal_physiological_respon0.39080034
173MP0005058_abnormal_lysosome_morphology0.38856861
174MP0000249_abnormal_blood_vessel0.38611522
175MP0003718_maternal_effect0.38369277
176MP0004883_abnormal_blood_vessel0.38025277
177MP0002090_abnormal_vision0.37689140
178MP0009384_cardiac_valve_regurgitation0.37619867
179MP0008873_increased_physiological_sensi0.37568146
180MP0003075_altered_response_to0.37021269
181MP0005464_abnormal_platelet_physiology0.36787745
182MP0002928_abnormal_bile_duct0.35058977
183MP0005452_abnormal_adipose_tissue0.32484428
184MP0005275_abnormal_skin_tensile0.32028565
185MP0005166_decreased_susceptibility_to0.31370434
186MP0002295_abnormal_pulmonary_circulatio0.31240019
187MP0010234_abnormal_vibrissa_follicle0.30565303

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.12178277
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.98389989
3Intrahepatic cholestasis (HP:0001406)6.79139081
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.22382498
5Xanthomatosis (HP:0000991)6.11912585
6Prolonged partial thromboplastin time (HP:0003645)6.01249323
7Hypobetalipoproteinemia (HP:0003563)5.95602733
8Hyperlipoproteinemia (HP:0010980)5.57235559
9Complement deficiency (HP:0004431)5.50818357
10Hyperammonemia (HP:0001987)4.75012446
11Hypolipoproteinemia (HP:0010981)4.66855857
12Hyperglycinemia (HP:0002154)4.61132573
13Hyperglycinuria (HP:0003108)4.57783867
14Epidermoid cyst (HP:0200040)4.51299776
15Ketosis (HP:0001946)4.44022361
16Joint hemorrhage (HP:0005261)4.42243897
17Abnormality of serine family amino acid metabolism (HP:0010894)4.38295884
18Abnormality of glycine metabolism (HP:0010895)4.38295884
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.35753197
20True hermaphroditism (HP:0010459)4.35047167
21Hypoalphalipoproteinemia (HP:0003233)4.28157990
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.24281116
23Abnormality of the common coagulation pathway (HP:0010990)4.19844174
24Abnormality of sulfur amino acid metabolism (HP:0004339)4.12175532
25Hypoglycemic coma (HP:0001325)3.98383822
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.97058169
27Abnormality of methionine metabolism (HP:0010901)3.96466899
28Abnormality of complement system (HP:0005339)3.96262216
29Fat malabsorption (HP:0002630)3.80577469
30Pancreatic fibrosis (HP:0100732)3.68710801
31Abnormality of fatty-acid metabolism (HP:0004359)3.65727141
32Abnormality of the intrinsic pathway (HP:0010989)3.61052313
33Hypercholesterolemia (HP:0003124)3.59846084
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.57369937
35Polyphagia (HP:0002591)3.44045096
36Abnormality of pyrimidine metabolism (HP:0004353)3.42537094
37Medial flaring of the eyebrow (HP:0010747)3.42516443
38Gait imbalance (HP:0002141)3.35934928
39Conjugated hyperbilirubinemia (HP:0002908)3.31147708
40Ketoacidosis (HP:0001993)3.30599665
41Split foot (HP:0001839)3.29676365
42Congenital primary aphakia (HP:0007707)3.23347511
43Pancreatic cysts (HP:0001737)3.22626265
44Abnormality of serum amino acid levels (HP:0003112)3.13531087
45Molar tooth sign on MRI (HP:0002419)3.09193268
46Abnormality of midbrain morphology (HP:0002418)3.09193268
47Hyperbilirubinemia (HP:0002904)3.07280111
48Abnormality of nucleobase metabolism (HP:0010932)3.04323957
49Myocardial infarction (HP:0001658)3.03171075
50Delayed CNS myelination (HP:0002188)3.01623689
51Septo-optic dysplasia (HP:0100842)3.00738232
52Nephrogenic diabetes insipidus (HP:0009806)2.96633152
53Hemiparesis (HP:0001269)2.94320917
54Genital tract atresia (HP:0001827)2.92316293
55Abnormal ciliary motility (HP:0012262)2.92267194
56Spontaneous abortion (HP:0005268)2.88031231
57Skin nodule (HP:0200036)2.86934101
58Steatorrhea (HP:0002570)2.86533554
59Abnormality of purine metabolism (HP:0004352)2.85217388
60Vaginal atresia (HP:0000148)2.82335211
61Hepatocellular carcinoma (HP:0001402)2.81561970
62Abnormality of the labia minora (HP:0012880)2.81435071
63Nephronophthisis (HP:0000090)2.80998429
64Metabolic acidosis (HP:0001942)2.78435176
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76236002
66Dicarboxylic aciduria (HP:0003215)2.76236002
67Systemic lupus erythematosus (HP:0002725)2.76229907
68Abnormal respiratory motile cilium physiology (HP:0012261)2.75835085
69Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.75169385
70Lethargy (HP:0001254)2.68481113
71Postaxial hand polydactyly (HP:0001162)2.66409359
72Sclerocornea (HP:0000647)2.65595376
73Short tibia (HP:0005736)2.65345541
74Aplasia/Hypoplasia of the tongue (HP:0010295)2.63386481
75Postaxial foot polydactyly (HP:0001830)2.62788875
76Occipital encephalocele (HP:0002085)2.60804649
77Myokymia (HP:0002411)2.59371026
78Abnormal respiratory motile cilium morphology (HP:0005938)2.57941628
79Abnormal respiratory epithelium morphology (HP:0012253)2.57941628
80Hypochromic microcytic anemia (HP:0004840)2.56375379
81Chronic hepatic failure (HP:0100626)2.55014880
82Aplasia/Hypoplasia of the tibia (HP:0005772)2.49638022
83Spastic diplegia (HP:0001264)2.48147955
84Cholecystitis (HP:0001082)2.47071935
85Abnormal gallbladder physiology (HP:0012438)2.47071935
86Malnutrition (HP:0004395)2.46028327
87Retinal dysplasia (HP:0007973)2.45893470
88Vascular calcification (HP:0004934)2.42373873
89Abnormal gallbladder morphology (HP:0012437)2.41766281
90Rhinitis (HP:0012384)2.40910187
91Cerebral edema (HP:0002181)2.40627536
92Gout (HP:0001997)2.39549602
93Focal motor seizures (HP:0011153)2.38912632
94Amyloidosis (HP:0011034)2.38391587
95Cholelithiasis (HP:0001081)2.37244558
96Hypoglycemic seizures (HP:0002173)2.36493816
97Broad foot (HP:0001769)2.36225572
98Synostosis involving the elbow (HP:0003938)2.35137489
99Humeroradial synostosis (HP:0003041)2.35137489
100Pancreatitis (HP:0001733)2.34742821
101Specific learning disability (HP:0001328)2.34598385
102Glomerulonephritis (HP:0000099)2.30966899
103Cystic liver disease (HP:0006706)2.29363918
104Acanthocytosis (HP:0001927)2.28418053
105Abnormality of proline metabolism (HP:0010907)2.28220253
106Hydroxyprolinuria (HP:0003080)2.28220253
107Neonatal onset (HP:0003623)2.28128231
108Irritability (HP:0000737)2.27408302
109Optic nerve hypoplasia (HP:0000609)2.25904279
110Esophageal varix (HP:0002040)2.25370318
111Hypertriglyceridemia (HP:0002155)2.23126447
112Hemorrhage of the eye (HP:0011885)2.22868139
113Type II lissencephaly (HP:0007260)2.22734446
114Sensorimotor neuropathy (HP:0007141)2.22442135
115Preaxial hand polydactyly (HP:0001177)2.21756175
116Anencephaly (HP:0002323)2.21352865
117Mitral stenosis (HP:0001718)2.20972528
118Cardiovascular calcification (HP:0011915)2.20058681
119Abnormality of the renal medulla (HP:0100957)2.20016672
120Brushfield spots (HP:0001088)2.19781641
121Vomiting (HP:0002013)2.19158111
122Poor coordination (HP:0002370)2.17390072
123Generalized aminoaciduria (HP:0002909)2.17361970
124Abnormal cartilage morphology (HP:0002763)2.16312633
125Increased corneal curvature (HP:0100692)2.14652473
126Keratoconus (HP:0000563)2.14652473
127Hepatoblastoma (HP:0002884)2.13886853
128Oligodactyly (hands) (HP:0001180)2.12569858
129Progressive cerebellar ataxia (HP:0002073)2.11617721
130Abnormal eating behavior (HP:0100738)2.09523033
131Late onset (HP:0003584)2.08835604
132Coronal craniosynostosis (HP:0004440)2.04143817
133Congenital hepatic fibrosis (HP:0002612)2.03204598
134Recurrent gram-negative bacterial infections (HP:0005420)2.03186430
135Enlarged kidneys (HP:0000105)2.01727418
136Menorrhagia (HP:0000132)2.00732176
137Megalencephaly (HP:0001355)2.00662439
138Increased serum pyruvate (HP:0003542)1.98861746
139Lissencephaly (HP:0001339)1.98439394
140Decreased central vision (HP:0007663)1.98103143
141Hypoplastic pelvis (HP:0008839)1.97154417
142Cortical dysplasia (HP:0002539)1.96986857
143Esophageal atresia (HP:0002032)1.96815487
144Gingival bleeding (HP:0000225)1.96549908
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.95579857
146Absent/shortened dynein arms (HP:0200106)1.95579857
147Abnormality of the gallbladder (HP:0005264)1.94625263
148Anophthalmia (HP:0000528)1.92518165
149Absent septum pellucidum (HP:0001331)1.90526595
150Proximal tubulopathy (HP:0000114)1.89588147
151Thrombophlebitis (HP:0004418)1.89497481
152Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88832337
153Opisthotonus (HP:0002179)1.87398976
154Male pseudohermaphroditism (HP:0000037)1.87128356
155Abnormal biliary tract physiology (HP:0012439)1.86827996
156Bile duct proliferation (HP:0001408)1.86827996
157Renal cortical cysts (HP:0000803)1.86333509
158Narrow forehead (HP:0000341)1.86317611
159Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86192219
160Degeneration of the lateral corticospinal tracts (HP:0002314)1.86192219
161Hyperinsulinemic hypoglycemia (HP:0000825)1.86132902
162Gastrointestinal atresia (HP:0002589)1.86094947
163Hemivertebrae (HP:0002937)1.85818507
164Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85752699
165Aplasia/Hypoplasia of the lens (HP:0008063)1.85683540
166Hyperglycemia (HP:0003074)1.85567352
167Acute encephalopathy (HP:0006846)1.83093724
168Increased purine levels (HP:0004368)1.81389230
169Hyperuricemia (HP:0002149)1.81389230
170Rickets (HP:0002748)1.81062118
171Nephritis (HP:0000123)1.80045282
172Lipid accumulation in hepatocytes (HP:0006561)1.79637425
173Elevated hepatic transaminases (HP:0002910)1.79338292
174Drooling (HP:0002307)1.78987404
175Acute necrotizing encephalopathy (HP:0006965)1.77735592
176Renal dysplasia (HP:0000110)1.77641450
177Aplasia involving bones of the extremities (HP:0009825)1.77129938
178Aplasia involving bones of the upper limbs (HP:0009823)1.77129938
179Aplasia of the phalanges of the hand (HP:0009802)1.77129938
180Oligodactyly (HP:0012165)1.77062410
181Nausea (HP:0002018)1.76037696
182Abnormality of the diencephalon (HP:0010662)1.75211419
183Alkalosis (HP:0001948)1.75185422
184Rib fusion (HP:0000902)1.74758176
185Hyperventilation (HP:0002883)1.73990557
186Morphological abnormality of the pyramidal tract (HP:0002062)1.73060096
187Abnormality of iron homeostasis (HP:0011031)1.72815622
188Abnormality of transition element cation homeostasis (HP:0011030)1.72625835
189Aplasia/Hypoplasia of the fibula (HP:0006492)1.71281636
190Pachygyria (HP:0001302)1.70990862
191Limb dystonia (HP:0002451)1.69421479
192Decreased testicular size (HP:0008734)1.69225171
193Preaxial foot polydactyly (HP:0001841)1.68371176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.98329440
2SIK14.68661134
3CASK4.35041948
4ERN14.06115591
5FGFR43.71938338
6TAOK33.07310302
7MARK13.00931703
8TRIB32.90580326
9PNCK2.83154118
10WNK32.67823498
11NTRK22.62098933
12INSRR2.57456508
13MAP3K42.55595769
14ERBB42.34501027
15LATS12.33843583
16CAMK1D2.33710174
17MST1R2.32411659
18BCR2.29330765
19MAP2K72.25129188
20TNIK2.24931100
21EPHA42.18039091
22DYRK22.07797803
23DYRK32.00350593
24MAP2K41.98797832
25MAPK131.97775683
26PKN21.97516266
27FRK1.83501900
28MAP4K21.83177484
29CSNK1G21.82492583
30TRIM281.69209835
31PIK3CG1.68354616
32ERBB31.61744385
33MAPK111.57224269
34CAMK1G1.56577930
35CSNK1G31.56558943
36BMPR1B1.52087724
37FGFR21.48812018
38FLT31.47186338
39CSNK1A1L1.44365775
40PRKAA21.43807231
41AKT31.35584971
42TSSK61.35407850
43NEK91.33900079
44PLK21.32761146
45PTK61.32688107
46TYK21.31730478
47WEE11.31699803
48ABL21.29256040
49DAPK21.18757411
50JAK21.15743288
51PDK31.14229302
52PDK41.14229302
53UHMK11.13788923
54RIPK11.13081962
55VRK11.11427407
56STK38L1.09204485
57RPS6KA41.07484052
58PRKCG1.05941484
59ADRBK21.03472033
60PAK61.00752331
61PDK20.98685298
62NTRK30.97198947
63PINK10.96894060
64JAK10.94346181
65WNK40.93278368
66MET0.93219666
67MAP3K70.91495107
68SRPK10.91132550
69PRKCE0.90896692
70TIE10.89923136
71KDR0.88990399
72CDK60.87454626
73GRK10.85925570
74LATS20.83575055
75MAP3K60.82989650
76CDK190.81433179
77MAP3K30.80935289
78MINK10.80834075
79MAPK120.80459389
80MYLK0.80451793
81DYRK1A0.79800410
82PRKAA10.79774617
83NUAK10.79367558
84TGFBR20.79008057
85PRKD30.78876085
86MAPK40.77840288
87PRKCZ0.76879058
88MAP2K30.76024555
89ERBB20.75242709
90STK390.74081131
91GSK3A0.74034104
92FGFR30.73609870
93PDGFRA0.72493661
94PKN10.71741312
95PRKACG0.69642752
96MKNK10.69622788
97PDPK10.69591806
98ROCK20.67326038
99CAMK2A0.67288017
100TBK10.66773637
101CDK30.65671002
102EPHB10.65628328
103EPHA30.65283588
104MAP2K10.64446610
105TGFBR10.64393108
106GRK60.62224817
107IRAK30.58251644
108CDK50.57978041
109PTK20.57043216
110SGK30.55787875
111CAMKK20.54787646
112RET0.54661756
113EPHB20.53934006
114CAMK2B0.53598021
115MAP3K100.53088154
116CSNK1A10.52871090
117PLK30.52831852
118CSK0.52745886
119CAMK2G0.52477275
120PIK3CA0.51811177
121PRKACA0.50822239
122STK160.50080396
123ZAK0.49665796
124MAPK150.48943360
125IGF1R0.48449947
126MTOR0.48390620
127ADRBK10.47780939
128DYRK1B0.46407963
129MKNK20.45285463
130CDK140.43238385
131PRKG10.42371738
132LIMK10.42260648
133CSF1R0.41410236
134PDK10.41175107
135CCNB10.41046058
136MAP3K110.40684615
137RPS6KA50.39315402
138CSNK1G10.38842498
139FER0.38832876
140CAMK10.38471042
141MAPK70.38259920
142CAMK2D0.37948448
143PRKACB0.37873745
144MAP3K140.37465248
145ICK0.37274500
146STK30.36889051
147MAP3K20.35977680
148NTRK10.35916327
149TYRO30.35716511
150SGK20.35409102
151VRK20.34253064
152PASK0.33546961
153MAP2K60.32704894
154MAP3K130.32442966
155CDK180.31454093
156BMX0.31419262
157KSR20.31273129
158YES10.30978473
159CDK40.30606560
160SGK4940.30453604
161SGK2230.30453604
162MOS0.30261210
163PIM20.29303351
164IRAK10.29184160
165PLK40.28759341
166CDK11A0.28620930
167PAK30.28248736
168PRKCQ0.27931411
169MAP3K50.27236190
170MAPKAPK30.26608101
171LMTK20.24404223
172EGFR0.24265582
173PAK20.24183207
174IKBKE0.23034462
175FGFR10.22633522

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.24839810
2Nitrogen metabolism_Homo sapiens_hsa009103.67881424
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.22559428
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12873274
5Arginine biosynthesis_Homo sapiens_hsa002203.00452390
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.69973181
7Fatty acid degradation_Homo sapiens_hsa000712.65384108
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.65291792
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64255655
10Tryptophan metabolism_Homo sapiens_hsa003802.63995983
11Complement and coagulation cascades_Homo sapiens_hsa046102.61378924
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46008901
13Propanoate metabolism_Homo sapiens_hsa006402.33521496
14PPAR signaling pathway_Homo sapiens_hsa033202.20423966
15Butanoate metabolism_Homo sapiens_hsa006502.19131868
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17256613
17Peroxisome_Homo sapiens_hsa041462.10625108
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06938500
19Fatty acid metabolism_Homo sapiens_hsa012122.06377713
20Oxidative phosphorylation_Homo sapiens_hsa001901.98097037
21Protein export_Homo sapiens_hsa030601.97983677
22Chemical carcinogenesis_Homo sapiens_hsa052041.87012610
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86138842
24beta-Alanine metabolism_Homo sapiens_hsa004101.83294840
25Parkinsons disease_Homo sapiens_hsa050121.81624699
26Caffeine metabolism_Homo sapiens_hsa002321.79700307
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.79607565
28Histidine metabolism_Homo sapiens_hsa003401.78083234
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73460032
30Staphylococcus aureus infection_Homo sapiens_hsa051501.69904514
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68072271
32Nicotine addiction_Homo sapiens_hsa050331.66609630
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.61908700
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61514980
35Retinol metabolism_Homo sapiens_hsa008301.61496635
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59102786
37Phenylalanine metabolism_Homo sapiens_hsa003601.58347049
38Pyruvate metabolism_Homo sapiens_hsa006201.56565579
39Tyrosine metabolism_Homo sapiens_hsa003501.45274473
40Selenocompound metabolism_Homo sapiens_hsa004501.43283941
41Bile secretion_Homo sapiens_hsa049761.42541942
42Sulfur metabolism_Homo sapiens_hsa009201.40852510
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37613336
44Fatty acid elongation_Homo sapiens_hsa000621.34058362
45Basal cell carcinoma_Homo sapiens_hsa052171.33780907
46Carbon metabolism_Homo sapiens_hsa012001.25260796
47Fat digestion and absorption_Homo sapiens_hsa049751.24057343
48Huntingtons disease_Homo sapiens_hsa050161.23961136
49Starch and sucrose metabolism_Homo sapiens_hsa005001.23099009
50Cocaine addiction_Homo sapiens_hsa050301.22960049
51Biosynthesis of amino acids_Homo sapiens_hsa012301.20142991
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17331177
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16308072
54ABC transporters_Homo sapiens_hsa020101.13121942
55* Cysteine and methionine metabolism_Homo sapiens_hsa002701.11806261
56Alzheimers disease_Homo sapiens_hsa050101.10257190
57Folate biosynthesis_Homo sapiens_hsa007901.08981511
58Phototransduction_Homo sapiens_hsa047441.07521949
59Cardiac muscle contraction_Homo sapiens_hsa042601.05217804
60Hedgehog signaling pathway_Homo sapiens_hsa043400.99628391
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.98894058
62Fatty acid biosynthesis_Homo sapiens_hsa000610.97888109
63Steroid biosynthesis_Homo sapiens_hsa001000.97830619
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97762866
65GABAergic synapse_Homo sapiens_hsa047270.96318093
66Vitamin B6 metabolism_Homo sapiens_hsa007500.95132263
67Glycerolipid metabolism_Homo sapiens_hsa005610.94116692
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93493996
69Axon guidance_Homo sapiens_hsa043600.89971004
70Arginine and proline metabolism_Homo sapiens_hsa003300.89050198
71Sulfur relay system_Homo sapiens_hsa041220.87492379
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.84982267
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84127261
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83562582
75Lysine degradation_Homo sapiens_hsa003100.83212538
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83207738
77Vitamin digestion and absorption_Homo sapiens_hsa049770.78758837
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78199470
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72491200
80Dopaminergic synapse_Homo sapiens_hsa047280.69120549
81Glutathione metabolism_Homo sapiens_hsa004800.68579594
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68478799
83Glutamatergic synapse_Homo sapiens_hsa047240.68101919
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67928353
85Morphine addiction_Homo sapiens_hsa050320.67837122
86Taste transduction_Homo sapiens_hsa047420.66241587
87Pentose phosphate pathway_Homo sapiens_hsa000300.64198192
88Amphetamine addiction_Homo sapiens_hsa050310.63578414
89Circadian entrainment_Homo sapiens_hsa047130.61051493
90* Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59738610
91Hippo signaling pathway_Homo sapiens_hsa043900.59032266
92Insulin secretion_Homo sapiens_hsa049110.56933921
93One carbon pool by folate_Homo sapiens_hsa006700.53230047
94Basal transcription factors_Homo sapiens_hsa030220.49658899
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47444139
96Circadian rhythm_Homo sapiens_hsa047100.45341692
97* Metabolic pathways_Homo sapiens_hsa011000.44397125
98Fanconi anemia pathway_Homo sapiens_hsa034600.43621223
99Melanogenesis_Homo sapiens_hsa049160.42119269
100Serotonergic synapse_Homo sapiens_hsa047260.41211636
101RNA polymerase_Homo sapiens_hsa030200.40209097
102Ribosome_Homo sapiens_hsa030100.40013946
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.39690052
104Insulin resistance_Homo sapiens_hsa049310.33934444
105Wnt signaling pathway_Homo sapiens_hsa043100.32144918
106Collecting duct acid secretion_Homo sapiens_hsa049660.32027800
107Prion diseases_Homo sapiens_hsa050200.30862969
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29748836
109Fructose and mannose metabolism_Homo sapiens_hsa000510.27544025
110Linoleic acid metabolism_Homo sapiens_hsa005910.24214308
111AMPK signaling pathway_Homo sapiens_hsa041520.23570459
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.22484966
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21092564
114Galactose metabolism_Homo sapiens_hsa000520.18752374
115Glucagon signaling pathway_Homo sapiens_hsa049220.17945872
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12651623
117Insulin signaling pathway_Homo sapiens_hsa049100.03431503
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02712085
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.02696423
120Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2224364
121Lysosome_Homo sapiens_hsa04142-0.2165766
122Amoebiasis_Homo sapiens_hsa05146-0.1943098
123African trypanosomiasis_Homo sapiens_hsa05143-0.1928217
124Protein digestion and absorption_Homo sapiens_hsa04974-0.1877807
125Regulation of autophagy_Homo sapiens_hsa04140-0.1830895
126Hepatitis C_Homo sapiens_hsa05160-0.1691203
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1572702
128Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1538162
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1517096
130Renin-angiotensin system_Homo sapiens_hsa04614-0.1512386
131Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1211463
132Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1128060
133Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1100898
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1079513
135Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0979422
136Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0911449
137Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0029500

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