CDON

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)5.41085147
2planar cell polarity pathway involved in neural tube closure (GO:0090179)5.24116916
3regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)5.02656282
4limb bud formation (GO:0060174)4.62949066
5presynaptic membrane assembly (GO:0097105)4.35031866
6protein heterotrimerization (GO:0070208)4.17283961
7hippo signaling (GO:0035329)4.13635810
8otic vesicle formation (GO:0030916)4.09823176
9collagen fibril organization (GO:0030199)4.05928112
10presynaptic membrane organization (GO:0097090)4.00461109
11pyrimidine nucleobase catabolic process (GO:0006208)3.84001976
12bone trabecula formation (GO:0060346)3.81636786
13paraxial mesoderm development (GO:0048339)3.76939175
14postsynaptic membrane organization (GO:0001941)3.70922186
15muscle cell fate commitment (GO:0042693)3.63503352
16axonal fasciculation (GO:0007413)3.63281993
17Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.60488122
18insulin-like growth factor receptor signaling pathway (GO:0048009)3.58571105
19neuron recognition (GO:0008038)3.54838629
20regulation of establishment of planar polarity (GO:0090175)3.54539422
21dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.52270627
22cerebral cortex radially oriented cell migration (GO:0021799)3.50982272
23negative regulation of chondrocyte differentiation (GO:0032331)3.38899447
24kidney morphogenesis (GO:0060993)3.35368131
25outer ear morphogenesis (GO:0042473)3.33625149
26central nervous system projection neuron axonogenesis (GO:0021952)3.32187828
27non-canonical Wnt signaling pathway (GO:0035567)3.31945413
28axon extension involved in axon guidance (GO:0048846)3.31359522
29neuron projection extension involved in neuron projection guidance (GO:1902284)3.31359522
30dorsal/ventral axis specification (GO:0009950)3.21995157
31plasma membrane repair (GO:0001778)3.18957960
32apical protein localization (GO:0045176)3.18658001
33retinal ganglion cell axon guidance (GO:0031290)3.17781418
34cornea development in camera-type eye (GO:0061303)3.14183159
35cell proliferation in forebrain (GO:0021846)3.14089584
36limb development (GO:0060173)3.12911588
37appendage development (GO:0048736)3.12911588
38positive regulation of myotube differentiation (GO:0010831)3.08301479
39chondrocyte proliferation (GO:0035988)3.06392454
40regulation of axon guidance (GO:1902667)3.06309190
41spinal cord development (GO:0021510)3.06266341
42establishment of tissue polarity (GO:0007164)3.05956442
43establishment of planar polarity (GO:0001736)3.05956442
44cytoplasmic mRNA processing body assembly (GO:0033962)3.04486809
45glucocorticoid receptor signaling pathway (GO:0042921)3.03453668
46negative regulation of fatty acid transport (GO:2000192)3.01076733
47gastrulation with mouth forming second (GO:0001702)3.00785654
48negative regulation of cartilage development (GO:0061037)2.99247587
49sequestering of extracellular ligand from receptor (GO:0035581)2.96287875
50nucleobase catabolic process (GO:0046113)2.96097703
51negative regulation of axon guidance (GO:1902668)2.93546451
52tongue development (GO:0043586)2.91849342
53regulation of heart morphogenesis (GO:2000826)2.91148133
54positive regulation of hormone biosynthetic process (GO:0046886)2.90882237
55heart morphogenesis (GO:0003007)2.90477001
56chondrocyte development (GO:0002063)2.87216977
57nonmotile primary cilium assembly (GO:0035058)2.86615926
58cochlea morphogenesis (GO:0090103)2.85989228
59craniofacial suture morphogenesis (GO:0097094)2.85905264
60axon extension (GO:0048675)2.85431878
61negative regulation of catenin import into nucleus (GO:0035414)2.83571738
62positive regulation of epithelial to mesenchymal transition (GO:0010718)2.82154709
63convergent extension (GO:0060026)2.82094992
64positive regulation of mesenchymal cell proliferation (GO:0002053)2.78707495
65positive regulation of glycogen biosynthetic process (GO:0045725)2.78263514
66organ induction (GO:0001759)2.78141072
67mesenchymal-epithelial cell signaling (GO:0060638)2.78090964
68regulation of development, heterochronic (GO:0040034)2.77198280
69metanephric mesenchyme development (GO:0072075)2.77082441
70camera-type eye morphogenesis (GO:0048593)2.76607161
71cell migration in hindbrain (GO:0021535)2.75382808
72calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.74109994
73suckling behavior (GO:0001967)2.72790921
74regulation of non-canonical Wnt signaling pathway (GO:2000050)2.72456836
75lung-associated mesenchyme development (GO:0060484)2.71928705
76olfactory bulb development (GO:0021772)2.70701701
77mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.70570337
78G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.70533168
79neuron cell-cell adhesion (GO:0007158)2.69208601
80embryonic cranial skeleton morphogenesis (GO:0048701)2.69139172
81proximal/distal pattern formation (GO:0009954)2.67483411
82intraciliary transport (GO:0042073)2.67067852
83negative regulation of axon extension involved in axon guidance (GO:0048843)2.66923751
84neuronal stem cell maintenance (GO:0097150)2.66545435
85hindbrain development (GO:0030902)2.65641867
86lens fiber cell development (GO:0070307)2.65344890
87generation of neurons (GO:0048699)2.64125877
88notochord development (GO:0030903)2.63487489
89epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63089794
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.62418918
91regulation of axon extension involved in axon guidance (GO:0048841)2.61936778
92central nervous system neuron axonogenesis (GO:0021955)2.61691540
93endodermal cell differentiation (GO:0035987)2.61346512
94dendrite morphogenesis (GO:0048813)2.60934261
95polarized epithelial cell differentiation (GO:0030859)2.60887058
96regulation of mesenchymal cell proliferation (GO:0010464)2.60759535
97myotube differentiation (GO:0014902)2.60636988
98embryonic skeletal joint morphogenesis (GO:0060272)2.59650278
99regulation of cartilage development (GO:0061035)2.59133708
100positive regulation of neuroblast proliferation (GO:0002052)2.58909629
101startle response (GO:0001964)2.58731803
102skeletal muscle fiber development (GO:0048741)2.58700207
103cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.58347824
104collagen metabolic process (GO:0032963)2.58152483
105regulation of cardioblast proliferation (GO:0003264)2.57170851
106regulation of secondary heart field cardioblast proliferation (GO:0003266)2.57170851
107corticosteroid receptor signaling pathway (GO:0031958)2.56518271
108ephrin receptor signaling pathway (GO:0048013)2.56301291
109regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.56213273
110protein localization to synapse (GO:0035418)2.55693985
111regulation of chondrocyte differentiation (GO:0032330)2.54849703
112negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53212985
113negative regulation of translation, ncRNA-mediated (GO:0040033)2.53212985
114regulation of translation, ncRNA-mediated (GO:0045974)2.53212985
115kidney mesenchyme development (GO:0072074)2.53060650
116regulation of transforming growth factor beta2 production (GO:0032909)2.52430359
117face morphogenesis (GO:0060325)2.52080652
118endocardial cushion morphogenesis (GO:0003203)2.51488679
119eye morphogenesis (GO:0048592)2.50547299
120cerebral cortex cell migration (GO:0021795)2.50514962
121radial glial cell differentiation (GO:0060019)2.49994349
122asymmetric protein localization (GO:0008105)2.49980574
123negative chemotaxis (GO:0050919)2.49442891
124regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.48953236
125regulation of catenin import into nucleus (GO:0035412)2.48819464
126mesenchyme morphogenesis (GO:0072132)2.48663932
127dendritic spine morphogenesis (GO:0060997)2.48620002
128regulation of timing of cell differentiation (GO:0048505)2.47731620
129peptidyl-lysine dimethylation (GO:0018027)2.46946807
130collagen catabolic process (GO:0030574)2.46784056
131multicellular organismal macromolecule metabolic process (GO:0044259)2.46549500
132organ growth (GO:0035265)2.45617087
133coronary vasculature morphogenesis (GO:0060977)2.45345176
134midbrain development (GO:0030901)2.44715962
135ionotropic glutamate receptor signaling pathway (GO:0035235)2.44689781
136positive regulation of cartilage development (GO:0061036)2.44462724
137establishment of nucleus localization (GO:0040023)2.44371618
138head development (GO:0060322)2.44266808
139embryonic camera-type eye development (GO:0031076)2.43484240
140vocalization behavior (GO:0071625)2.43356610
141neuron projection extension (GO:1990138)2.42713036
142anatomical structure regression (GO:0060033)2.42348639
143negative regulation of astrocyte differentiation (GO:0048712)2.42043123
144positive regulation of gastrulation (GO:2000543)2.41862279
145transmission of nerve impulse (GO:0019226)2.41460670
146regulation of smoothened signaling pathway (GO:0008589)2.41335237
147embryonic foregut morphogenesis (GO:0048617)2.40643947
148regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.40234453
149dopaminergic neuron differentiation (GO:0071542)2.40044178
150positive regulation of cardiac muscle cell differentiation (GO:2000727)2.38916814
151neuron migration (GO:0001764)2.38405534
152inner ear receptor stereocilium organization (GO:0060122)2.38315770
153inner ear morphogenesis (GO:0042472)2.35974930
154mesenchyme development (GO:0060485)2.35873927
155morphogenesis of an epithelial sheet (GO:0002011)2.35835388
156heart valve formation (GO:0003188)2.35543175
157somite development (GO:0061053)2.35077373
158cell surface receptor signaling pathway involved in heart development (GO:0061311)2.35053898
159regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.35045520
160hindlimb morphogenesis (GO:0035137)2.34947602
161cytoskeletal anchoring at plasma membrane (GO:0007016)2.34721195
162artery development (GO:0060840)2.34706944
163striated muscle cell proliferation (GO:0014855)2.34276945
164regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.34126676
165positive regulation of synapse assembly (GO:0051965)2.33810576
166regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.33386748
167spinal cord association neuron differentiation (GO:0021527)2.33315927
168epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.33095656
169endocardial cushion development (GO:0003197)2.33095579
170epithelial cell differentiation involved in prostate gland development (GO:0060742)2.32945026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.76370715
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.94005432
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.37617072
4GBX2_23144817_ChIP-Seq_PC3_Human3.02775144
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.00319806
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.92218662
7* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.78477748
8WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.66042877
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44073695
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38303948
11CLOCK_20551151_ChIP-Seq_293T_Human2.38262036
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.37736697
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.36633300
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.30226768
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.30181605
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21537038
17TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.18563138
18* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.14611398
19TAF15_26573619_Chip-Seq_HEK293_Human2.13666902
20DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.12917737
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04301997
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.00311008
23ZFP281_18757296_ChIP-ChIP_E14_Mouse1.96701305
24FOXM1_23109430_ChIP-Seq_U2OS_Human1.94742695
25* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.94329888
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.93385936
27ZFP281_27345836_Chip-Seq_ESCs_Mouse1.92663806
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88615559
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85636738
30RNF2_27304074_Chip-Seq_NSC_Mouse1.85615605
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.85543540
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83858781
33* ISL1_27105846_Chip-Seq_CPCs_Mouse1.83655560
34FUS_26573619_Chip-Seq_HEK293_Human1.83459574
35IGF1R_20145208_ChIP-Seq_DFB_Human1.76656130
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76382261
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76382261
38FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.76311666
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73991804
40P300_19829295_ChIP-Seq_ESCs_Human1.72644702
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72394638
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.71670609
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70620510
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.70391471
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.67281201
46P300_27058665_Chip-Seq_ZR-75-30cells_Human1.66041958
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65025551
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.64720265
49EWS_26573619_Chip-Seq_HEK293_Human1.64487558
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61972301
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61814582
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61350584
53SMAD4_21799915_ChIP-Seq_A2780_Human1.61218190
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60063599
55* KDM2B_26808549_Chip-Seq_JURKAT_Human1.59353743
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58408786
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.58173530
58* KDM2B_26808549_Chip-Seq_K562_Human1.58116654
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56908235
60BRD4_25478319_ChIP-Seq_HGPS_Human1.56009957
61* KDM2B_26808549_Chip-Seq_DND41_Human1.55762705
62ZNF274_21170338_ChIP-Seq_K562_Hela1.55276213
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.54865040
64* SMAD3_21741376_ChIP-Seq_EPCs_Human1.54724103
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52478303
66* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51897896
67* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50543284
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.49479686
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49220833
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.49081211
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.48144841
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.48019968
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47699356
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46351901
75* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45206992
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42172322
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.41107310
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40736220
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40225152
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40225152
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.39953498
82* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.38044793
83* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37817410
84* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37723767
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37588214
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37519117
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36037584
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36000241
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35486557
90UBF1/2_26484160_Chip-Seq_HMECs_Human1.34056386
91AR_21572438_ChIP-Seq_LNCaP_Human1.33273522
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33234803
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.33137435
94* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32633078
95* CJUN_26792858_Chip-Seq_BT549_Human1.32621051
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32169034
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30121546
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29564924
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28666004
100SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27509120
101STAT3_23295773_ChIP-Seq_U87_Human1.25953926
102* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25528788
103KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23537682
104MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22732602
105REST_21632747_ChIP-Seq_MESCs_Mouse1.22261883
106VDR_22108803_ChIP-Seq_LS180_Human1.22113147
107AR_25329375_ChIP-Seq_VCAP_Human1.21858181
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21604515
109JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21173173
110TP53_16413492_ChIP-PET_HCT116_Human1.21092122
111CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20022404
112TBX20_22080862_ChIP-Seq_HEART_Mouse1.19817817
113TBX20_22328084_ChIP-Seq_HEART_Mouse1.19817817
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18781835
115* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18720507
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18649974
117SOX9_26525672_Chip-Seq_HEART_Mouse1.18349011
118SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18182405
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18054547
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17781087
121CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17724390
122JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17547407
123MYC_22102868_ChIP-Seq_BL_Human1.17277370
124TCF7_22412390_ChIP-Seq_EML_Mouse1.17221676
125RING1B_27294783_Chip-Seq_ESCs_Mouse1.16497850
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16403135
127SOX2_21211035_ChIP-Seq_LN229_Gbm1.16063879
128TCF4_18268006_ChIP-ChIP_LS174T_Human1.15206469
129* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15137725
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.14808392
131HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14131998
132DROSHA_22980978_ChIP-Seq_HELA_Human1.13928166
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13626011
134SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12453541
135ESR1_21235772_ChIP-Seq_MCF-7_Human1.11838761
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11603372
137CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11050666
138SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10562807
139* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10183771
140UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10019350
141RUNX2_22187159_ChIP-Seq_PCA_Human1.09898820
142SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09892121
143AHR_22903824_ChIP-Seq_MCF-7_Human1.09455808
144* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09085503
145TCF4_23295773_ChIP-Seq_U87_Human1.07132148
146PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07015321
147FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06592409
148BCAT_22108803_ChIP-Seq_LS180_Human1.06574429
149RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06563940
150TP53_18474530_ChIP-ChIP_U2OS_Human1.05968738
151ARNT_22903824_ChIP-Seq_MCF-7_Human1.04888431
152TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04749452
153CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03530016
154CREB1_26743006_Chip-Seq_LNCaP_Human1.01335410
155CHD1_26751641_Chip-Seq_LNCaP_Human1.00689485
156POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00156372
157ESR2_21235772_ChIP-Seq_MCF-7_Human0.99859469
158SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98078300
159TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97679868
160RUNX1_27514584_Chip-Seq_MCF-7_Human0.97491790
161EZH2_27294783_Chip-Seq_ESCs_Mouse0.97440367
162TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97435563
163STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96939659
164* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96464231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.53568639
2MP0010030_abnormal_orbit_morphology3.64606081
3MP0005503_abnormal_tendon_morphology3.31132389
4MP0003705_abnormal_hypodermis_morpholog3.26317633
5MP0005275_abnormal_skin_tensile3.02623670
6MP0000778_abnormal_nervous_system2.69196354
7MP0000733_abnormal_muscle_development2.66659525
8MP0000537_abnormal_urethra_morphology2.66496244
9MP0009053_abnormal_anal_canal2.36968885
10MP0005377_hearing/vestibular/ear_phenot2.21976049
11MP0003878_abnormal_ear_physiology2.21976049
12MP0003385_abnormal_body_wall2.18605823
13MP0005076_abnormal_cell_differentiation2.17608403
14MP0005623_abnormal_meninges_morphology2.12868680
15MP0004885_abnormal_endolymph2.06867142
16MP0004272_abnormal_basement_membrane1.99617741
17MP0005248_abnormal_Harderian_gland1.92507630
18* MP0000428_abnormal_craniofacial_morphol1.91077879
19MP0004859_abnormal_synaptic_plasticity1.80783903
20MP0002108_abnormal_muscle_morphology1.80420043
21MP0002102_abnormal_ear_morphology1.78450373
22MP0009250_abnormal_appendicular_skeleto1.77926522
23MP0001299_abnormal_eye_distance/1.75849301
24MP0003122_maternal_imprinting1.73473799
25MP0003942_abnormal_urinary_system1.71834718
26MP0005508_abnormal_skeleton_morphology1.71435425
27MP0002234_abnormal_pharynx_morphology1.71382276
28MP0003283_abnormal_digestive_organ1.69858178
29MP0003938_abnormal_ear_development1.67201281
30MP0000049_abnormal_middle_ear1.65940442
31MP0000750_abnormal_muscle_regeneration1.62831036
32MP0003279_aneurysm1.57870815
33MP0002249_abnormal_larynx_morphology1.55596335
34MP0004270_analgesia1.51160458
35MP0003115_abnormal_respiratory_system1.51125877
36MP0005257_abnormal_intraocular_pressure1.50940084
37MP0000566_synostosis1.50041079
38MP0002184_abnormal_innervation1.50022360
39MP0002282_abnormal_trachea_morphology1.49891654
40MP0000751_myopathy1.49557800
41* MP0003755_abnormal_palate_morphology1.47662960
42MP0003937_abnormal_limbs/digits/tail_de1.47144732
43MP0006054_spinal_hemorrhage1.46860200
44MP0000534_abnormal_ureter_morphology1.45722039
45* MP0002932_abnormal_joint_morphology1.45498269
46MP0000631_abnormal_neuroendocrine_gland1.45326292
47MP0008789_abnormal_olfactory_epithelium1.44447304
48MP0004233_abnormal_muscle_weight1.42663938
49MP0009384_cardiac_valve_regurgitation1.41694303
50MP0003123_paternal_imprinting1.41000786
51* MP0003935_abnormal_craniofacial_develop1.38144604
52MP0003880_abnormal_central_pattern1.35751132
53MP0002896_abnormal_bone_mineralization1.35347874
54MP0009780_abnormal_chondrocyte_physiolo1.33070639
55MP0010234_abnormal_vibrissa_follicle1.32082225
56MP0006072_abnormal_retinal_apoptosis1.30004569
57MP0003121_genomic_imprinting1.29210883
58MP0000026_abnormal_inner_ear1.28961492
59* MP0002116_abnormal_craniofacial_bone1.27827822
60MP0001958_emphysema1.27783907
61MP0000383_abnormal_hair_follicle1.26680842
62MP0000579_abnormal_nail_morphology1.26532178
63* MP0003861_abnormal_nervous_system1.23815405
64MP0000955_abnormal_spinal_cord1.23695606
65* MP0002233_abnormal_nose_morphology1.23604958
66MP0010678_abnormal_skin_adnexa1.22865559
67MP0004133_heterotaxia1.22543866
68MP0002697_abnormal_eye_size1.20742098
69MP0002638_abnormal_pupillary_reflex1.20269198
70MP0004197_abnormal_fetal_growth/weight/1.20259728
71MP0004145_abnormal_muscle_electrophysio1.19572788
72MP0000163_abnormal_cartilage_morphology1.18746083
73MP0010352_gastrointestinal_tract_polyps1.17633422
74MP0001486_abnormal_startle_reflex1.17473734
75MP0002653_abnormal_ependyma_morphology1.16936380
76MP0005187_abnormal_penis_morphology1.16524510
77* MP0000432_abnormal_head_morphology1.15227191
78MP0001346_abnormal_lacrimal_gland1.14753326
79MP0006292_abnormal_olfactory_placode1.12205304
80MP0001849_ear_inflammation1.11954411
81MP0003567_abnormal_fetal_cardiomyocyte1.11816653
82MP0002092_abnormal_eye_morphology1.11661597
83MP0000759_abnormal_skeletal_muscle1.11124265
84MP0002060_abnormal_skin_morphology1.10726602
85MP0003890_abnormal_embryonic-extraembry1.10602514
86MP0004087_abnormal_muscle_fiber1.09554993
87MP0003119_abnormal_digestive_system1.09270285
88MP0002115_abnormal_skeleton_extremities1.09254239
89MP0001293_anophthalmia1.08394739
90MP0002735_abnormal_chemical_nociception1.08123613
91MP0005391_vision/eye_phenotype1.07857453
92MP0002557_abnormal_social/conspecific_i1.07671560
93MP0003941_abnormal_skin_development1.07245213
94MP0004134_abnormal_chest_morphology1.05628011
95* MP0002114_abnormal_axial_skeleton1.05210904
96MP0002909_abnormal_adrenal_gland1.04332873
97* MP0002152_abnormal_brain_morphology1.04191474
98MP0005171_absent_coat_pigmentation1.03521714
99MP0002063_abnormal_learning/memory/cond1.02775601
100MP0003136_yellow_coat_color1.02080189
101* MP0002109_abnormal_limb_morphology1.02078117
102MP0001984_abnormal_olfaction1.01793715
103MP0000762_abnormal_tongue_morphology1.01557914
104MP0002084_abnormal_developmental_patter1.01490722
105MP0003635_abnormal_synaptic_transmissio1.00973496
106MP0002111_abnormal_tail_morphology1.00848417
107MP0003091_abnormal_cell_migration1.00776583
108MP0003566_abnormal_cell_adhesion0.99910749
109MP0005367_renal/urinary_system_phenotyp0.98964312
110MP0000516_abnormal_urinary_system0.98964312
111MP0002752_abnormal_somatic_nervous0.98727052
112MP0005197_abnormal_uvea_morphology0.97694269
113MP0005423_abnormal_somatic_nervous0.97525842
114MP0002572_abnormal_emotion/affect_behav0.97154669
115* MP0002882_abnormal_neuron_morphology0.96985354
116MP0003950_abnormal_plasma_membrane0.95011668
117MP0009703_decreased_birth_body0.94759048
118MP0002736_abnormal_nociception_after0.94566049
119MP0003787_abnormal_imprinting0.94501709
120MP0002925_abnormal_cardiovascular_devel0.94042605
121MP0002877_abnormal_melanocyte_morpholog0.93933866
122MP0001177_atelectasis0.93415890
123MP0002113_abnormal_skeleton_development0.93318282
124MP0001286_abnormal_eye_development0.93115938
125MP0002085_abnormal_embryonic_tissue0.92894331
126MP0000003_abnormal_adipose_tissue0.92764941
127MP0005369_muscle_phenotype0.92687449
128MP0002751_abnormal_autonomic_nervous0.91746301
129MP0000569_abnormal_digit_pigmentation0.91302560
130MP0000767_abnormal_smooth_muscle0.90264006
131MP0006276_abnormal_autonomic_nervous0.89590476
132MP0004742_abnormal_vestibular_system0.89484385
133MP0000747_muscle_weakness0.88472618
134MP0001485_abnormal_pinna_reflex0.88027900
135MP0002734_abnormal_mechanical_nocicepti0.87837177
136MP0001340_abnormal_eyelid_morphology0.87675253
137MP0005499_abnormal_olfactory_system0.86471922
138MP0005394_taste/olfaction_phenotype0.86471922
139MP0005253_abnormal_eye_physiology0.86284577
140MP0002938_white_spotting0.85822692
141MP0001963_abnormal_hearing_physiology0.85816533
142MP0002106_abnormal_muscle_physiology0.83896525
143MP0010630_abnormal_cardiac_muscle0.83219039
144MP0010368_abnormal_lymphatic_system0.82544911
145MP0005551_abnormal_eye_electrophysiolog0.82129656
146MP0002177_abnormal_outer_ear0.82008743
147* MP0002081_perinatal_lethality0.81181792

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.33190216
2Shallow orbits (HP:0000586)4.23761437
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.86562007
4Short 4th metacarpal (HP:0010044)3.86562007
5Premature rupture of membranes (HP:0001788)3.84212157
6Type 1 muscle fiber predominance (HP:0003803)3.53359211
7Ankle contracture (HP:0006466)3.45906117
8Abnormality of the 4th metacarpal (HP:0010012)3.25640973
9Cutaneous finger syndactyly (HP:0010554)3.12952058
10Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.03478294
11Morphological abnormality of the middle ear (HP:0008609)3.03168754
12Broad metatarsal (HP:0001783)2.97965769
13Vitreoretinal degeneration (HP:0000655)2.75756942
14Cutaneous syndactyly (HP:0012725)2.72892588
15Hypoplastic ischia (HP:0003175)2.71776036
16Round ear (HP:0100830)2.70453334
17Aortic dissection (HP:0002647)2.69689445
18Mildly elevated creatine phosphokinase (HP:0008180)2.69152210
19Cerebral aneurysm (HP:0004944)2.66554453
20Abnormality of the labia minora (HP:0012880)2.62747429
21High anterior hairline (HP:0009890)2.59720849
22Bladder diverticulum (HP:0000015)2.58738275
23Aplasia involving bones of the extremities (HP:0009825)2.57463845
24Aplasia involving bones of the upper limbs (HP:0009823)2.57463845
25Aplasia of the phalanges of the hand (HP:0009802)2.57463845
26Increased connective tissue (HP:0009025)2.49802473
27Coronal craniosynostosis (HP:0004440)2.43711606
28Increased density of long bones (HP:0006392)2.43532070
29Mitral valve prolapse (HP:0001634)2.42943881
30Bell-shaped thorax (HP:0001591)2.40183959
31Septo-optic dysplasia (HP:0100842)2.38218213
32Mesomelia (HP:0003027)2.36834228
33Abnormality of the ischium (HP:0003174)2.36219667
34Spinal rigidity (HP:0003306)2.33314556
35Difficulty running (HP:0009046)2.32892279
36Aortic aneurysm (HP:0004942)2.30508202
37Popliteal pterygium (HP:0009756)2.26857804
38Preaxial foot polydactyly (HP:0001841)2.26531746
39Midline defect of the nose (HP:0004122)2.26156601
40Hip contracture (HP:0003273)2.25747207
41Pterygium (HP:0001059)2.24757892
42Dilatation of the ascending aorta (HP:0005111)2.24687483
43Atrophic scars (HP:0001075)2.24561151
44Deviation of the hallux (HP:0010051)2.24317784
45True hermaphroditism (HP:0010459)2.22776420
46Neonatal short-limb short stature (HP:0008921)2.18896462
47Thin ribs (HP:0000883)2.17510702
48Renal hypoplasia (HP:0000089)2.17044697
49Slender build (HP:0001533)2.14621344
50Soft skin (HP:0000977)2.12905874
51Mild short stature (HP:0003502)2.11741542
52Increased variability in muscle fiber diameter (HP:0003557)2.10976750
53Wrist flexion contracture (HP:0001239)2.10748710
54Aqueductal stenosis (HP:0002410)2.10051114
55Deformed tarsal bones (HP:0008119)2.09655537
56Hallux valgus (HP:0001822)2.09584296
57Renal duplication (HP:0000075)2.09550419
58Genu recurvatum (HP:0002816)2.08931746
59Asymmetry of the thorax (HP:0001555)2.06844692
60Broad thumb (HP:0011304)2.06075631
61Nephronophthisis (HP:0000090)2.02958130
62Aplasia/Hypoplasia of the sternum (HP:0006714)2.00543501
63Calcaneovalgus deformity (HP:0001848)2.00513429
64Scapular winging (HP:0003691)2.00222880
65Intestinal atresia (HP:0011100)1.99804912
66Fibular hypoplasia (HP:0003038)1.99201822
67Optic nerve hypoplasia (HP:0000609)1.98225289
68Focal motor seizures (HP:0011153)1.98194118
69Follicular hyperkeratosis (HP:0007502)1.97430260
70Genital tract atresia (HP:0001827)1.97257052
71Vaginal atresia (HP:0000148)1.96585238
72Abnormality of the aortic arch (HP:0012303)1.95607690
73Thin bony cortex (HP:0002753)1.95351861
74Broad toe (HP:0001837)1.95268019
75Wormian bones (HP:0002645)1.95257442
76Bowel diverticulosis (HP:0005222)1.94761734
77Abnormality of skeletal muscle fiber size (HP:0012084)1.94548551
78Pancreatic fibrosis (HP:0100732)1.94323440
79Broad ribs (HP:0000885)1.93432807
80Abnormality of the calcaneus (HP:0008364)1.93060416
81Anophthalmia (HP:0000528)1.92638525
82Fragile skin (HP:0001030)1.92151657
83Drooling (HP:0002307)1.92118964
84Rib fusion (HP:0000902)1.91807868
85Wide anterior fontanel (HP:0000260)1.91102612
86Buphthalmos (HP:0000557)1.91069003
87Broad long bones (HP:0005622)1.91023633
88Broad hallux (HP:0010055)1.90769835
89Joint laxity (HP:0001388)1.90422758
90Bronchomalacia (HP:0002780)1.90419414
91Exostoses (HP:0100777)1.90261714
92Camptodactyly of toe (HP:0001836)1.90225334
93Tracheomalacia (HP:0002779)1.89012074
94Malignant hyperthermia (HP:0002047)1.88804293
95Oligodactyly (HP:0012165)1.87945154
96Limited hip movement (HP:0008800)1.87848010
97Megalencephaly (HP:0001355)1.87813961
98Flat cornea (HP:0007720)1.87709566
99Shawl scrotum (HP:0000049)1.87674661
100Spinal cord lesions (HP:0100561)1.87562920
101Syringomyelia (HP:0003396)1.87562920
102Abnormality of the pubic bones (HP:0003172)1.87477921
103Abnormality of incisor morphology (HP:0011063)1.87368093
104Short 1st metacarpal (HP:0010034)1.87102272
105Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.87102272
106Renovascular hypertension (HP:0100817)1.86021491
107Long clavicles (HP:0000890)1.85219056
108Postaxial hand polydactyly (HP:0001162)1.83955539
109Arterial tortuosity (HP:0005116)1.83886144
110Abnormality of the phalanges of the 2nd finger (HP:0009541)1.83823427
111Hyperacusis (HP:0010780)1.83789207
112Muscle fiber splitting (HP:0003555)1.82964987
113Difficulty climbing stairs (HP:0003551)1.82819472
114Dislocated radial head (HP:0003083)1.82732986
115Vascular tortuosity (HP:0004948)1.82472505
116Turricephaly (HP:0000262)1.82354728
117Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.82295934
118Abnormality of dentin (HP:0010299)1.82283096
119Blue sclerae (HP:0000592)1.81411718
120Absent phalangeal crease (HP:0006109)1.80922614
121Broad phalanx (HP:0006009)1.80528123
122Trigonocephaly (HP:0000243)1.79992266
123Tarsal synostosis (HP:0008368)1.79913879
124Bifid tongue (HP:0010297)1.79118664
125Ulnar deviation of the wrist (HP:0003049)1.78802673
126Alacrima (HP:0000522)1.78801347
127Overgrowth (HP:0001548)1.78381174
128Chin dimple (HP:0010751)1.77240750
129Broad phalanges of the hand (HP:0009768)1.77017076
130Abnormality of the antihelix (HP:0009738)1.76486316
131Distal arthrogryposis (HP:0005684)1.76485903
132Abnormality of the radial head (HP:0003995)1.76103338
133Limb-girdle muscle weakness (HP:0003325)1.75788771
134Abnormality of the renal medulla (HP:0100957)1.75225923
135Lymphangioma (HP:0100764)1.75195635
136Infantile muscular hypotonia (HP:0008947)1.74791602
137Macroorchidism (HP:0000053)1.74645919
138Renal dysplasia (HP:0000110)1.74481478
139Focal seizures (HP:0007359)1.74437895
140Aplasia of the musculature (HP:0100854)1.74052463
141Pancreatic cysts (HP:0001737)1.73983673
142Gait imbalance (HP:0002141)1.73898092
143Broad finger (HP:0001500)1.73719226
144Preaxial hand polydactyly (HP:0001177)1.73655800
145Knee flexion contracture (HP:0006380)1.73211449
146Postaxial foot polydactyly (HP:0001830)1.72796758
147Abnormality of the lower motor neuron (HP:0002366)1.72730091
148Cervical subluxation (HP:0003308)1.72665529
149Omphalocele (HP:0001539)1.72472217
150Hyperventilation (HP:0002883)1.71108492
151Choanal stenosis (HP:0000452)1.71075584
152Exotropia (HP:0000577)1.70101874
153Abnormality of midbrain morphology (HP:0002418)1.69081777
154Molar tooth sign on MRI (HP:0002419)1.69081777
155Short foot (HP:0001773)1.68675270
156Hepatoblastoma (HP:0002884)1.68406715
157Partial duplication of the phalanx of hand (HP:0009999)1.67717385
158Hypoplasia of the ulna (HP:0003022)1.67455414
159Volvulus (HP:0002580)1.67090347
160Fetal akinesia sequence (HP:0001989)1.67003430
161Absent frontal sinuses (HP:0002688)1.66966510
162Partial duplication of thumb phalanx (HP:0009944)1.66376570
163Hyperextensible skin (HP:0000974)1.65810215
164Aplasia/Hypoplasia of the tongue (HP:0010295)1.65314026
165Chronic hepatic failure (HP:0100626)1.64489634
166Excessive salivation (HP:0003781)1.64037658
167Medial flaring of the eyebrow (HP:0010747)1.62216400
168Facial hemangioma (HP:0000329)1.62042832
169Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61999977
170Cupped ear (HP:0000378)1.61604163
171Vertebral arch anomaly (HP:0008438)1.61362977
172Esophageal atresia (HP:0002032)1.61034171
173Congenital primary aphakia (HP:0007707)1.59424123
174Labial hypoplasia (HP:0000066)1.58568887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.14398083
2EPHB23.93539660
3TNIK3.90653786
4LATS13.61369407
5DDR23.61019812
6CASK3.28519303
7MARK13.16075681
8MAP3K102.88062658
9PKN22.83977410
10PDGFRA2.76923087
11TTN2.75193243
12SIK12.74693128
13NTRK12.55763990
14PNCK2.52644556
15MOS2.52063030
16CDK122.48237127
17NTRK22.28677905
18BCR2.00750275
19PTK61.90853795
20EEF2K1.89346178
21FGFR21.86515970
22RIPK11.85166885
23FGFR11.83361178
24MAP3K41.81064453
25EPHA41.77239040
26MAPK151.75102988
27CAMK1G1.71478782
28LATS21.67402422
29CAMK1D1.60091058
30MTOR1.57216596
31STK31.50309906
32CDK61.49569206
33FRK1.46202486
34WNK31.40825488
35TRIM281.39201036
36ICK1.38836339
37MAPK131.35421572
38NTRK31.34883928
39PAK41.33964826
40MAP4K21.33940857
41PAK21.33416113
42DYRK21.32114040
43DMPK1.29313791
44PLK21.26329011
45ERBB31.26250783
46PRKD31.20869977
47TYRO31.18981909
48PDGFRB1.17388874
49FER1.13840122
50BMPR1B1.13565492
51CSNK1G21.12381601
52INSRR1.12188817
53BRD41.11882724
54MAP2K71.04601506
55BMX1.03860983
56FGFR31.01935028
57PTK21.00880949
58MKNK10.98373251
59PRKCG0.98130932
60ERBB20.97465635
61ILK0.95707567
62UHMK10.93036363
63LRRK20.88921489
64EPHA30.88058197
65WEE10.86529823
66SGK2230.85617497
67SGK4940.85617497
68DYRK1B0.83615836
69ROCK20.82857104
70SGK20.82567802
71YES10.82352473
72STK390.81455649
73CDK30.80909267
74PLK40.79739977
75KSR10.77999749
76MAP2K10.77800484
77CDK150.75504826
78ROCK10.75214903
79WNK40.74885645
80CDC70.72959110
81CDK140.72171464
82PAK30.70621300
83CDK50.69853697
84NUAK10.69812149
85PRKCH0.69718553
86CDK180.69267696
87MET0.68617394
88PAK60.67726351
89CSNK1A1L0.67057800
90ALK0.66473241
91CDK11A0.65978067
92MAP3K70.65432278
93FGFR40.65396476
94RPS6KB20.65247616
95NEK20.65100510
96MINK10.64863281
97CDC42BPA0.64449743
98WNK10.63063085
99MARK20.63035687
100CDK190.62916383
101PASK0.62915042
102CDK90.62679102
103PRKCE0.61716241
104RET0.60844675
105PLK30.60826484
106MKNK20.59561985
107DYRK1A0.59388724
108GRK10.58919308
109TAF10.57837103
110PRKD20.57149221
111PKN10.56511116
112GSK3A0.56186824
113HIPK20.54127457
114BRSK20.53692881
115MELK0.53677612
116CSNK1G30.52068493
117STK38L0.50614414
118TGFBR10.50278247
119STK110.49358215
120SIK20.48784509
121PINK10.47762143
122ATM0.47639321
123AKT20.47586747
124PRKCZ0.45996896
125RPS6KA40.44356679
126CAMK2A0.44352026
127ZAK0.44177377
128CDK40.43476274
129CSNK1D0.43074516
130NLK0.43034318
131RPS6KB10.42738601
132AKT10.42361500
133CHUK0.41523456
134CAMK2B0.40911293
135PRKD10.40845215
136MAPK90.39580352
137INSR0.38500480
138MAPK10.37348692
139GSK3B0.36939314
140EPHB10.36163522
141MAPK100.36029874
142LMTK20.35863003
143MAPK80.35695846
144SRC0.35574306
145CDK10.35511008
146CHEK10.35490988
147CSNK1G10.35384130
148CSNK1E0.34737081
149PRKDC0.33788469
150MUSK0.32655543
151CDK20.32504278
152MAPK140.31939705
153NEK90.31830001
154TRPM70.31796196

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.91052800
2ECM-receptor interaction_Homo sapiens_hsa045122.71081344
3Nicotine addiction_Homo sapiens_hsa050332.63234812
4Hippo signaling pathway_Homo sapiens_hsa043902.30285324
5Hedgehog signaling pathway_Homo sapiens_hsa043402.23943516
6Focal adhesion_Homo sapiens_hsa045102.22867269
7Proteoglycans in cancer_Homo sapiens_hsa052052.13164995
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.08929226
9Adherens junction_Homo sapiens_hsa045202.06058860
10MicroRNAs in cancer_Homo sapiens_hsa052061.86330551
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.85879934
12Protein digestion and absorption_Homo sapiens_hsa049741.80756542
13Dilated cardiomyopathy_Homo sapiens_hsa054141.80292586
14Chronic myeloid leukemia_Homo sapiens_hsa052201.79024677
15TGF-beta signaling pathway_Homo sapiens_hsa043501.78044386
16Notch signaling pathway_Homo sapiens_hsa043301.76737797
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.70203736
18Axon guidance_Homo sapiens_hsa043601.67788049
19Wnt signaling pathway_Homo sapiens_hsa043101.66818890
20Circadian entrainment_Homo sapiens_hsa047131.60067451
21Nitrogen metabolism_Homo sapiens_hsa009101.55466571
22Small cell lung cancer_Homo sapiens_hsa052221.55425658
23Glutamatergic synapse_Homo sapiens_hsa047241.50122225
24Viral myocarditis_Homo sapiens_hsa054161.49748830
25Cocaine addiction_Homo sapiens_hsa050301.46997509
26Tight junction_Homo sapiens_hsa045301.46229823
27mTOR signaling pathway_Homo sapiens_hsa041501.45428176
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.42786997
29Endometrial cancer_Homo sapiens_hsa052131.41661493
30Melanogenesis_Homo sapiens_hsa049161.41299749
31Prostate cancer_Homo sapiens_hsa052151.41209258
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40847145
33Bladder cancer_Homo sapiens_hsa052191.40659448
34Lysine degradation_Homo sapiens_hsa003101.38759096
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.38081958
36Dorso-ventral axis formation_Homo sapiens_hsa043201.36522452
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35060170
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.34779555
39Amphetamine addiction_Homo sapiens_hsa050311.33470749
40Insulin secretion_Homo sapiens_hsa049111.33359150
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33251892
42Colorectal cancer_Homo sapiens_hsa052101.33152988
43Glioma_Homo sapiens_hsa052141.29990205
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.20558793
45Pathways in cancer_Homo sapiens_hsa052001.19612545
46HTLV-I infection_Homo sapiens_hsa051661.19546797
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19283259
48Renal cell carcinoma_Homo sapiens_hsa052111.18754601
49Amoebiasis_Homo sapiens_hsa051461.18394627
50PI3K-Akt signaling pathway_Homo sapiens_hsa041511.14241627
51Dopaminergic synapse_Homo sapiens_hsa047281.13679981
52Taste transduction_Homo sapiens_hsa047421.12371816
53Pancreatic cancer_Homo sapiens_hsa052121.12219004
54Propanoate metabolism_Homo sapiens_hsa006401.10935260
55Melanoma_Homo sapiens_hsa052181.08330126
56Longevity regulating pathway - mammal_Homo sapiens_hsa042111.07197283
57Fanconi anemia pathway_Homo sapiens_hsa034601.06598178
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05487755
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03752040
60Basal transcription factors_Homo sapiens_hsa030221.03731729
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02799519
62AMPK signaling pathway_Homo sapiens_hsa041521.00921006
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99894689
64Estrogen signaling pathway_Homo sapiens_hsa049150.98807169
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94880116
66FoxO signaling pathway_Homo sapiens_hsa040680.94417122
67mRNA surveillance pathway_Homo sapiens_hsa030150.94109429
68Morphine addiction_Homo sapiens_hsa050320.93845801
69Non-small cell lung cancer_Homo sapiens_hsa052230.92769122
70Insulin resistance_Homo sapiens_hsa049310.92373083
71Long-term depression_Homo sapiens_hsa047300.92165285
72Thyroid cancer_Homo sapiens_hsa052160.91806825
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91185883
74Insulin signaling pathway_Homo sapiens_hsa049100.91106353
75GABAergic synapse_Homo sapiens_hsa047270.91011249
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.90777248
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90566087
78Rap1 signaling pathway_Homo sapiens_hsa040150.88234202
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88092582
80Butanoate metabolism_Homo sapiens_hsa006500.87088609
81Cell cycle_Homo sapiens_hsa041100.87085257
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85678783
83ErbB signaling pathway_Homo sapiens_hsa040120.85154591
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84172218
85Gap junction_Homo sapiens_hsa045400.84105621
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.83463592
87Steroid biosynthesis_Homo sapiens_hsa001000.82534646
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82055041
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81653523
90Serotonergic synapse_Homo sapiens_hsa047260.79658464
91Type II diabetes mellitus_Homo sapiens_hsa049300.79218552
92Viral carcinogenesis_Homo sapiens_hsa052030.77714286
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77230709
94RNA degradation_Homo sapiens_hsa030180.73935840
95VEGF signaling pathway_Homo sapiens_hsa043700.73674620
96Oxytocin signaling pathway_Homo sapiens_hsa049210.73662399
97MAPK signaling pathway_Homo sapiens_hsa040100.72976931
98Glucagon signaling pathway_Homo sapiens_hsa049220.72969109
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72508902
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69889820
101p53 signaling pathway_Homo sapiens_hsa041150.69279028
102Platelet activation_Homo sapiens_hsa046110.69250956
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.68749083
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67734310
105Non-homologous end-joining_Homo sapiens_hsa034500.67438231
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66948454
107Alcoholism_Homo sapiens_hsa050340.66283125
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66179676
109GnRH signaling pathway_Homo sapiens_hsa049120.65434553
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64923388
111HIF-1 signaling pathway_Homo sapiens_hsa040660.64020008
112Salivary secretion_Homo sapiens_hsa049700.63290514
113Long-term potentiation_Homo sapiens_hsa047200.63164152
114Olfactory transduction_Homo sapiens_hsa047400.61582451
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60742745
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.60608079
117Toxoplasmosis_Homo sapiens_hsa051450.60421317
118Prolactin signaling pathway_Homo sapiens_hsa049170.60361032
119Cardiac muscle contraction_Homo sapiens_hsa042600.59525490
120Gastric acid secretion_Homo sapiens_hsa049710.59124322
121Renin secretion_Homo sapiens_hsa049240.58235593
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58210828
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57693577
124Thyroid hormone synthesis_Homo sapiens_hsa049180.57159937
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.57012946
126Oocyte meiosis_Homo sapiens_hsa041140.56817558
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56107673
128Ovarian steroidogenesis_Homo sapiens_hsa049130.55266663
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54996455
130Hepatitis B_Homo sapiens_hsa051610.54723655
131Acute myeloid leukemia_Homo sapiens_hsa052210.54542088
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.54226215
133Protein export_Homo sapiens_hsa030600.54164922
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53832500
135Ras signaling pathway_Homo sapiens_hsa040140.53572717
136Ether lipid metabolism_Homo sapiens_hsa005650.52835546
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52190134
138Linoleic acid metabolism_Homo sapiens_hsa005910.51871700
139Phototransduction_Homo sapiens_hsa047440.49866002
140TNF signaling pathway_Homo sapiens_hsa046680.49334286
141Endocytosis_Homo sapiens_hsa041440.48678204
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48385390
143Cholinergic synapse_Homo sapiens_hsa047250.47687891
144Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47471894
145Choline metabolism in cancer_Homo sapiens_hsa052310.45885059
146Circadian rhythm_Homo sapiens_hsa047100.45597024
147cAMP signaling pathway_Homo sapiens_hsa040240.45438815

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