

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.12801664 |
| 2 | ribosomal small subunit assembly (GO:0000028) | 5.71864799 |
| 3 | proteasome assembly (GO:0043248) | 5.44036969 |
| 4 | viral transcription (GO:0019083) | 4.85445304 |
| 5 | translational termination (GO:0006415) | 4.75466819 |
| 6 | base-excision repair, AP site formation (GO:0006285) | 4.69674993 |
| 7 | maturation of SSU-rRNA (GO:0030490) | 4.64439515 |
| 8 | ribosomal large subunit biogenesis (GO:0042273) | 4.55386119 |
| 9 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.54375197 |
| 10 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.47406430 |
| 11 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.46149638 |
| 12 | cotranslational protein targeting to membrane (GO:0006613) | 4.45863248 |
| 13 | translational elongation (GO:0006414) | 4.42760861 |
| 14 | protein targeting to ER (GO:0045047) | 4.41550362 |
| 15 | ubiquinone biosynthetic process (GO:0006744) | 4.35103103 |
| 16 | ribosomal small subunit biogenesis (GO:0042274) | 4.32482558 |
| 17 | protein localization to endoplasmic reticulum (GO:0070972) | 4.20961578 |
| 18 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.19317721 |
| 19 | ATP synthesis coupled proton transport (GO:0015986) | 4.12883708 |
| 20 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.12883708 |
| 21 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.08945381 |
| 22 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.08656699 |
| 23 | ubiquinone metabolic process (GO:0006743) | 4.02906489 |
| 24 | oxidative phosphorylation (GO:0006119) | 4.02028030 |
| 25 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.99749153 |
| 26 | translational initiation (GO:0006413) | 3.95627868 |
| 27 | formation of translation preinitiation complex (GO:0001731) | 3.92259104 |
| 28 | translation (GO:0006412) | 3.91372864 |
| 29 | mannosylation (GO:0097502) | 3.90922651 |
| 30 | termination of RNA polymerase III transcription (GO:0006386) | 3.88866729 |
| 31 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.88866729 |
| 32 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.82504007 |
| 33 | regulation of mitochondrial translation (GO:0070129) | 3.81078610 |
| 34 | viral life cycle (GO:0019058) | 3.80144527 |
| 35 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.78941155 |
| 36 | cellular protein complex disassembly (GO:0043624) | 3.75839671 |
| 37 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.75517099 |
| 38 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.74776124 |
| 39 | negative regulation of ligase activity (GO:0051352) | 3.74776124 |
| 40 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.73334406 |
| 41 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.70857649 |
| 42 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.70636162 |
| 43 | protein deneddylation (GO:0000338) | 3.69018573 |
| 44 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.68015815 |
| 45 | negative regulation of telomere maintenance (GO:0032205) | 3.67233121 |
| 46 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.67116670 |
| 47 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.66305123 |
| 48 | GTP biosynthetic process (GO:0006183) | 3.66017668 |
| 49 | peptidyl-histidine modification (GO:0018202) | 3.64885997 |
| 50 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.62770458 |
| 51 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.61313772 |
| 52 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.61110690 |
| 53 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.60812028 |
| 54 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.60749780 |
| 55 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.60355946 |
| 56 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.60355946 |
| 57 | deoxyribonucleotide catabolic process (GO:0009264) | 3.59796360 |
| 58 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.57573965 |
| 59 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.57573965 |
| 60 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.57573965 |
| 61 | platelet dense granule organization (GO:0060155) | 3.57439585 |
| 62 | pseudouridine synthesis (GO:0001522) | 3.56208636 |
| 63 | cullin deneddylation (GO:0010388) | 3.54513050 |
| 64 | respiratory chain complex IV assembly (GO:0008535) | 3.48849597 |
| 65 | inner mitochondrial membrane organization (GO:0007007) | 3.48131441 |
| 66 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.47778952 |
| 67 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.47778952 |
| 68 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.44572753 |
| 69 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.44572753 |
| 70 | DNA strand elongation (GO:0022616) | 3.42982162 |
| 71 | cellular component biogenesis (GO:0044085) | 3.42957733 |
| 72 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.41602261 |
| 73 | quinone biosynthetic process (GO:1901663) | 3.40364492 |
| 74 | GDP-mannose metabolic process (GO:0019673) | 3.40345458 |
| 75 | UTP biosynthetic process (GO:0006228) | 3.40340593 |
| 76 | glyoxylate metabolic process (GO:0046487) | 3.39990187 |
| 77 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.38963509 |
| 78 | chaperone-mediated protein transport (GO:0072321) | 3.38798302 |
| 79 | rRNA modification (GO:0000154) | 3.38357127 |
| 80 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.38248362 |
| 81 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.38248362 |
| 82 | NADH dehydrogenase complex assembly (GO:0010257) | 3.38248362 |
| 83 | L-serine metabolic process (GO:0006563) | 3.38086655 |
| 84 | rRNA processing (GO:0006364) | 3.34983341 |
| 85 | protein complex biogenesis (GO:0070271) | 3.33087834 |
| 86 | DNA replication checkpoint (GO:0000076) | 3.30931037 |
| 87 | nucleobase biosynthetic process (GO:0046112) | 3.30812721 |
| 88 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.29780660 |
| 89 | L-methionine salvage (GO:0071267) | 3.29224407 |
| 90 | L-methionine biosynthetic process (GO:0071265) | 3.29224407 |
| 91 | amino acid salvage (GO:0043102) | 3.29224407 |
| 92 | telomere maintenance via recombination (GO:0000722) | 3.28734606 |
| 93 | deoxyribose phosphate catabolic process (GO:0046386) | 3.28316045 |
| 94 | purine nucleobase biosynthetic process (GO:0009113) | 3.27177103 |
| 95 | protein targeting to mitochondrion (GO:0006626) | 3.27116877 |
| 96 | cytochrome complex assembly (GO:0017004) | 3.24301119 |
| 97 | metallo-sulfur cluster assembly (GO:0031163) | 3.24259838 |
| 98 | iron-sulfur cluster assembly (GO:0016226) | 3.24259838 |
| 99 | CTP biosynthetic process (GO:0006241) | 3.23635009 |
| 100 | CTP metabolic process (GO:0046036) | 3.23635009 |
| 101 | DNA replication initiation (GO:0006270) | 3.21929922 |
| 102 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.21878922 |
| 103 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.21878922 |
| 104 | rRNA methylation (GO:0031167) | 3.21403934 |
| 105 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.20848553 |
| 106 | rRNA metabolic process (GO:0016072) | 3.20715032 |
| 107 | positive regulation of mitochondrial fission (GO:0090141) | 3.20082575 |
| 108 | protein neddylation (GO:0045116) | 3.19324781 |
| 109 | positive regulation of ligase activity (GO:0051351) | 3.19131976 |
| 110 | respiratory electron transport chain (GO:0022904) | 3.18424599 |
| 111 | ribosome biogenesis (GO:0042254) | 3.17745449 |
| 112 | establishment of protein localization to mitochondrion (GO:0072655) | 3.17502449 |
| 113 | protein complex disassembly (GO:0043241) | 3.16995783 |
| 114 | spliceosomal snRNP assembly (GO:0000387) | 3.16244891 |
| 115 | electron transport chain (GO:0022900) | 3.14771938 |
| 116 | tRNA processing (GO:0008033) | 3.11745083 |
| 117 | purine deoxyribonucleotide catabolic process (GO:0009155) | 3.11584352 |
| 118 | DNA double-strand break processing (GO:0000729) | 3.11253329 |
| 119 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.09541626 |
| 120 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.08743669 |
| 121 | macromolecular complex disassembly (GO:0032984) | 3.08614123 |
| 122 | UTP metabolic process (GO:0046051) | 3.08093223 |
| 123 | 7-methylguanosine mRNA capping (GO:0006370) | 3.07901731 |
| 124 | 7-methylguanosine RNA capping (GO:0009452) | 3.04752549 |
| 125 | RNA capping (GO:0036260) | 3.04752549 |
| 126 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.03616914 |
| 127 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.02747751 |
| 128 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.02747751 |
| 129 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.00926623 |
| 130 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.00045749 |
| 131 | tRNA metabolic process (GO:0006399) | 2.99332407 |
| 132 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 2.97954426 |
| 133 | tRNA aminoacylation (GO:0043039) | 2.94321671 |
| 134 | amino acid activation (GO:0043038) | 2.94321671 |
| 135 | T cell migration (GO:0072678) | 2.92416726 |
| 136 | tRNA aminoacylation for protein translation (GO:0006418) | 2.91881708 |
| 137 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.91048800 |
| 138 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.91048800 |
| 139 | mitochondrial RNA metabolic process (GO:0000959) | 2.91040244 |
| 140 | base-excision repair (GO:0006284) | 2.90916325 |
| 141 | protein localization to mitochondrion (GO:0070585) | 2.90749788 |
| 142 | C-terminal protein lipidation (GO:0006501) | 2.89234542 |
| 143 | DNA ligation (GO:0006266) | 2.86903841 |
| 144 | establishment of integrated proviral latency (GO:0075713) | 2.85958811 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.28996477 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.22943719 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.05381978 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.97723777 |
| 5 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.97148696 |
| 6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.97047363 |
| 7 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.95612104 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.64666633 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.50442294 |
| 10 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.05314137 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.99700174 |
| 12 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.99090058 |
| 13 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.88763236 |
| 14 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.64108679 |
| 15 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.63262245 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.62393467 |
| 17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.58841327 |
| 18 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.54136040 |
| 19 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.47861314 |
| 20 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.44775368 |
| 21 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.43224241 |
| 22 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.42498302 |
| 23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.41599572 |
| 24 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.22510005 |
| 25 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.21685459 |
| 26 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.21371496 |
| 27 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.20290160 |
| 28 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.13911137 |
| 29 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.09930069 |
| 30 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.08887871 |
| 31 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.07643909 |
| 32 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.06744667 |
| 33 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.98073339 |
| 34 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.98024399 |
| 35 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.93221873 |
| 36 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.82514979 |
| 37 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.81795127 |
| 38 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.81238955 |
| 39 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.78546218 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.76043239 |
| 41 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.75747526 |
| 42 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.71712045 |
| 43 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.70552537 |
| 44 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.69298803 |
| 45 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.66058273 |
| 46 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.64211057 |
| 47 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.57598375 |
| 48 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.56572714 |
| 49 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.55876627 |
| 50 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.49188013 |
| 51 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.47252744 |
| 52 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.46919004 |
| 53 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.45854888 |
| 54 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.41465801 |
| 55 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.40373019 |
| 56 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.39535881 |
| 57 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.38579651 |
| 58 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.37279037 |
| 59 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.34334951 |
| 60 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.31474784 |
| 61 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.29281937 |
| 62 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.25949279 |
| 63 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.25100909 |
| 64 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.23504201 |
| 65 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.19958552 |
| 66 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.18531674 |
| 67 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.16012682 |
| 68 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.09792362 |
| 69 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.09782228 |
| 70 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.07075996 |
| 71 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.06752471 |
| 72 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.06646699 |
| 73 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.05525544 |
| 74 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.04979950 |
| 75 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.03166032 |
| 76 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.03083252 |
| 77 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.02818569 |
| 78 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.00682070 |
| 79 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.98921707 |
| 80 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.98596392 |
| 81 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.98261204 |
| 82 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.98104411 |
| 83 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.97247408 |
| 84 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.97098192 |
| 85 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96668443 |
| 86 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.96512532 |
| 87 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.96009304 |
| 88 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.94548145 |
| 89 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.94391643 |
| 90 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.93316233 |
| 91 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.92973277 |
| 92 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.92671575 |
| 93 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.92063221 |
| 94 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.87918743 |
| 95 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.87893650 |
| 96 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.87059359 |
| 97 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.86998894 |
| 98 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.86196137 |
| 99 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.85885687 |
| 100 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.85645656 |
| 101 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.84510672 |
| 102 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.84274053 |
| 103 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.84043243 |
| 104 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.83640857 |
| 105 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.83068999 |
| 106 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.82248103 |
| 107 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.80497408 |
| 108 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.78841671 |
| 109 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.78260918 |
| 110 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.77660943 |
| 111 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.77594256 |
| 112 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.77199007 |
| 113 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.76954332 |
| 114 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.76459659 |
| 115 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.76208715 |
| 116 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.75288954 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.91116452 |
| 2 | MP0002653_abnormal_ependyma_morphology | 4.46481001 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 3.50554197 |
| 4 | MP0002102_abnormal_ear_morphology | 3.47987125 |
| 5 | MP0003806_abnormal_nucleotide_metabolis | 3.32940157 |
| 6 | MP0004147_increased_porphyrin_level | 3.19962614 |
| 7 | MP0009379_abnormal_foot_pigmentation | 3.12713961 |
| 8 | MP0008058_abnormal_DNA_repair | 3.07263822 |
| 9 | MP0008995_early_reproductive_senescence | 3.02507531 |
| 10 | MP0010094_abnormal_chromosome_stability | 2.95610387 |
| 11 | MP0003186_abnormal_redox_activity | 2.68803415 |
| 12 | MP0003111_abnormal_nucleus_morphology | 2.67992841 |
| 13 | MP0003077_abnormal_cell_cycle | 2.67485084 |
| 14 | MP0005645_abnormal_hypothalamus_physiol | 2.57210561 |
| 15 | MP0006036_abnormal_mitochondrial_physio | 2.55321828 |
| 16 | MP0008789_abnormal_olfactory_epithelium | 2.37382617 |
| 17 | MP0002396_abnormal_hematopoietic_system | 2.33693087 |
| 18 | MP0005075_abnormal_melanosome_morpholog | 2.21941139 |
| 19 | MP0000490_abnormal_crypts_of | 2.15183537 |
| 20 | MP0008932_abnormal_embryonic_tissue | 2.12255142 |
| 21 | MP0003786_premature_aging | 2.06843721 |
| 22 | MP0008007_abnormal_cellular_replicative | 2.05592029 |
| 23 | MP0010030_abnormal_orbit_morphology | 2.04844187 |
| 24 | MP0009333_abnormal_splenocyte_physiolog | 2.00082468 |
| 25 | MP0003718_maternal_effect | 1.99126600 |
| 26 | MP0005394_taste/olfaction_phenotype | 1.97083383 |
| 27 | MP0005499_abnormal_olfactory_system | 1.97083383 |
| 28 | MP0008057_abnormal_DNA_replication | 1.90447254 |
| 29 | MP0003878_abnormal_ear_physiology | 1.89170160 |
| 30 | MP0005377_hearing/vestibular/ear_phenot | 1.89170160 |
| 31 | MP0002132_abnormal_respiratory_system | 1.82429317 |
| 32 | MP0003763_abnormal_thymus_physiology | 1.78123460 |
| 33 | MP0005408_hypopigmentation | 1.71893796 |
| 34 | MP0005671_abnormal_response_to | 1.69784207 |
| 35 | MP0003656_abnormal_erythrocyte_physiolo | 1.67825818 |
| 36 | MP0002938_white_spotting | 1.63622624 |
| 37 | MP0000749_muscle_degeneration | 1.59336943 |
| 38 | MP0001835_abnormal_antigen_presentation | 1.58053108 |
| 39 | MP0006292_abnormal_olfactory_placode | 1.49863405 |
| 40 | MP0001346_abnormal_lacrimal_gland | 1.49419629 |
| 41 | MP0009785_altered_susceptibility_to | 1.46039752 |
| 42 | MP0003122_maternal_imprinting | 1.44266246 |
| 43 | MP0004043_abnormal_pH_regulation | 1.41708642 |
| 44 | MP0005058_abnormal_lysosome_morphology | 1.37305078 |
| 45 | MP0006035_abnormal_mitochondrial_morpho | 1.36695952 |
| 46 | MP0000685_abnormal_immune_system | 1.34704834 |
| 47 | MP0001764_abnormal_homeostasis | 1.34133897 |
| 48 | MP0001529_abnormal_vocalization | 1.32582827 |
| 49 | MP0000358_abnormal_cell_content/ | 1.30167784 |
| 50 | MP0001730_embryonic_growth_arrest | 1.29412068 |
| 51 | MP0003646_muscle_fatigue | 1.29316623 |
| 52 | MP0002160_abnormal_reproductive_system | 1.27904400 |
| 53 | MP0003724_increased_susceptibility_to | 1.26044606 |
| 54 | MP0000689_abnormal_spleen_morphology | 1.25449775 |
| 55 | MP0005397_hematopoietic_system_phenotyp | 1.23987426 |
| 56 | MP0001545_abnormal_hematopoietic_system | 1.23987426 |
| 57 | MP0002722_abnormal_immune_system | 1.23048830 |
| 58 | MP0001853_heart_inflammation | 1.22411473 |
| 59 | MP0003136_yellow_coat_color | 1.22294078 |
| 60 | MP0002398_abnormal_bone_marrow | 1.22080474 |
| 61 | MP0002019_abnormal_tumor_incidence | 1.20195304 |
| 62 | MP0004145_abnormal_muscle_electrophysio | 1.19949471 |
| 63 | MP0003252_abnormal_bile_duct | 1.19930941 |
| 64 | MP0002736_abnormal_nociception_after | 1.17845578 |
| 65 | MP0002095_abnormal_skin_pigmentation | 1.17801748 |
| 66 | MP0002148_abnormal_hypersensitivity_rea | 1.17375342 |
| 67 | MP0008004_abnormal_stomach_pH | 1.17212751 |
| 68 | MP0004142_abnormal_muscle_tone | 1.16898914 |
| 69 | MP0000313_abnormal_cell_death | 1.16856039 |
| 70 | MP0006054_spinal_hemorrhage | 1.16044486 |
| 71 | MP0003866_abnormal_defecation | 1.15006229 |
| 72 | MP0000372_irregular_coat_pigmentation | 1.14328098 |
| 73 | MP0005451_abnormal_body_composition | 1.13083953 |
| 74 | MP0001984_abnormal_olfaction | 1.12000965 |
| 75 | MP0005025_abnormal_response_to | 1.11626508 |
| 76 | MP0002429_abnormal_blood_cell | 1.09860427 |
| 77 | MP0002420_abnormal_adaptive_immunity | 1.09714526 |
| 78 | MP0002405_respiratory_system_inflammati | 1.09529395 |
| 79 | MP0003880_abnormal_central_pattern | 1.08276727 |
| 80 | MP0001819_abnormal_immune_cell | 1.07448191 |
| 81 | MP0002277_abnormal_respiratory_mucosa | 1.07376199 |
| 82 | MP0000703_abnormal_thymus_morphology | 1.05702564 |
| 83 | MP0000716_abnormal_immune_system | 1.04611091 |
| 84 | MP0002723_abnormal_immune_serum | 1.04030422 |
| 85 | MP0004742_abnormal_vestibular_system | 1.03913978 |
| 86 | MP0004782_abnormal_surfactant_physiolog | 1.03731498 |
| 87 | MP0005084_abnormal_gallbladder_morpholo | 1.02932304 |
| 88 | MP0005636_abnormal_mineral_homeostasis | 1.01955123 |
| 89 | MP0005332_abnormal_amino_acid | 1.01042361 |
| 90 | MP0001485_abnormal_pinna_reflex | 1.00969692 |
| 91 | MP0000750_abnormal_muscle_regeneration | 1.00533607 |
| 92 | MP0005174_abnormal_tail_pigmentation | 0.99931805 |
| 93 | MP0000350_abnormal_cell_proliferation | 0.99866784 |
| 94 | MP0001800_abnormal_humoral_immune | 0.99053333 |
| 95 | MP0004084_abnormal_cardiac_muscle | 0.98585606 |
| 96 | MP0001119_abnormal_female_reproductive | 0.98436937 |
| 97 | MP0001873_stomach_inflammation | 0.96692554 |
| 98 | MP0008873_increased_physiological_sensi | 0.96450468 |
| 99 | MP0000465_gastrointestinal_hemorrhage | 0.95723191 |
| 100 | MP0002452_abnormal_antigen_presenting | 0.95663799 |
| 101 | MP0001293_anophthalmia | 0.93488417 |
| 102 | MP0000653_abnormal_sex_gland | 0.92954391 |
| 103 | MP0003315_abnormal_perineum_morphology | 0.92620021 |
| 104 | MP0000049_abnormal_middle_ear | 0.92210132 |
| 105 | MP0000858_altered_metastatic_potential | 0.92209983 |
| 106 | MP0004133_heterotaxia | 0.91898575 |
| 107 | MP0000516_abnormal_urinary_system | 0.90709966 |
| 108 | MP0005367_renal/urinary_system_phenotyp | 0.90709966 |
| 109 | MP0001929_abnormal_gametogenesis | 0.90511183 |
| 110 | MP0002876_abnormal_thyroid_physiology | 0.88735408 |
| 111 | MP0005000_abnormal_immune_tolerance | 0.87691891 |
| 112 | MP0008260_abnormal_autophagy | 0.87145335 |
| 113 | MP0003137_abnormal_impulse_conducting | 0.86903327 |
| 114 | MP0006082_CNS_inflammation | 0.86647475 |
| 115 | MP0005389_reproductive_system_phenotype | 0.86386279 |
| 116 | MP0005253_abnormal_eye_physiology | 0.85934263 |
| 117 | MP0003221_abnormal_cardiomyocyte_apopto | 0.85296992 |
| 118 | MP0005410_abnormal_fertilization | 0.84582246 |
| 119 | MP0001905_abnormal_dopamine_level | 0.83901239 |
| 120 | MP0006276_abnormal_autonomic_nervous | 0.83704756 |
| 121 | MP0002080_prenatal_lethality | 0.83410363 |
| 122 | MP0000343_altered_response_to | 0.83265809 |
| 123 | MP0005248_abnormal_Harderian_gland | 0.82754448 |
| 124 | MP0010155_abnormal_intestine_physiology | 0.82365538 |
| 125 | MP0001986_abnormal_taste_sensitivity | 0.80791481 |
| 126 | MP0001270_distended_abdomen | 0.80514920 |
| 127 | MP0008877_abnormal_DNA_methylation | 0.80505263 |
| 128 | MP0009697_abnormal_copulation | 0.80425910 |
| 129 | MP0008875_abnormal_xenobiotic_pharmacok | 0.79634838 |
| 130 | MP0001697_abnormal_embryo_size | 0.78305194 |
| 131 | MP0001661_extended_life_span | 0.78301986 |
| 132 | MP0008469_abnormal_protein_level | 0.77944858 |
| 133 | MP0005365_abnormal_bile_salt | 0.77474245 |
| 134 | MP0003698_abnormal_male_reproductive | 0.77329720 |
| 135 | MP0009278_abnormal_bone_marrow | 0.76651281 |
| 136 | MP0002210_abnormal_sex_determination | 0.76085936 |
| 137 | MP0002419_abnormal_innate_immunity | 0.75910275 |
| 138 | MP0004808_abnormal_hematopoietic_stem | 0.75445144 |
| 139 | MP0001145_abnormal_male_reproductive | 0.75170485 |
| 140 | MP0003567_abnormal_fetal_cardiomyocyte | 0.74735450 |
| 141 | MP0002234_abnormal_pharynx_morphology | 0.74430586 |
| 142 | MP0005464_abnormal_platelet_physiology | 0.73890809 |
| 143 | MP0002733_abnormal_thermal_nociception | 0.73733566 |
| 144 | MP0001919_abnormal_reproductive_system | 0.72817443 |
| 145 | MP0005551_abnormal_eye_electrophysiolog | 0.72139263 |
| 146 | MP0004036_abnormal_muscle_relaxation | 0.71897175 |
| 147 | MP0001845_abnormal_inflammatory_respons | 0.71135459 |
| 148 | MP0002233_abnormal_nose_morphology | 0.71090810 |
| 149 | MP0000015_abnormal_ear_pigmentation | 0.69840081 |
| 150 | MP0005266_abnormal_metabolism | 0.69536848 |
| 151 | MP0001790_abnormal_immune_system | 0.67649265 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.31002978 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.16838031 |
| 3 | Hepatocellular necrosis (HP:0001404) | 4.67997466 |
| 4 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.67468458 |
| 5 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.67468458 |
| 6 | Hepatic necrosis (HP:0002605) | 4.49184941 |
| 7 | Mitochondrial inheritance (HP:0001427) | 4.31180907 |
| 8 | Acute necrotizing encephalopathy (HP:0006965) | 4.06707080 |
| 9 | Increased CSF lactate (HP:0002490) | 4.03584467 |
| 10 | 3-Methylglutaconic aciduria (HP:0003535) | 3.90357390 |
| 11 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.82044770 |
| 12 | Increased hepatocellular lipid droplets (HP:0006565) | 3.75492688 |
| 13 | Increased serum lactate (HP:0002151) | 3.68504650 |
| 14 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.49227312 |
| 15 | Reticulocytopenia (HP:0001896) | 3.47998587 |
| 16 | Aplastic anemia (HP:0001915) | 3.47394233 |
| 17 | Exertional dyspnea (HP:0002875) | 3.46169396 |
| 18 | Lipid accumulation in hepatocytes (HP:0006561) | 3.44891101 |
| 19 | Cerebral hypomyelination (HP:0006808) | 3.42890723 |
| 20 | Acute encephalopathy (HP:0006846) | 3.41998825 |
| 21 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.33561218 |
| 22 | Lactic acidosis (HP:0003128) | 3.32023285 |
| 23 | Increased intramyocellular lipid droplets (HP:0012240) | 3.25923696 |
| 24 | Birth length less than 3rd percentile (HP:0003561) | 3.24754976 |
| 25 | Oral leukoplakia (HP:0002745) | 3.22633792 |
| 26 | Progressive macrocephaly (HP:0004481) | 3.14122712 |
| 27 | Macrocytic anemia (HP:0001972) | 3.13990918 |
| 28 | Type I transferrin isoform profile (HP:0003642) | 3.08279045 |
| 29 | Renal Fanconi syndrome (HP:0001994) | 3.07913139 |
| 30 | Microretrognathia (HP:0000308) | 3.06945892 |
| 31 | Exercise intolerance (HP:0003546) | 2.96815218 |
| 32 | Increased muscle lipid content (HP:0009058) | 2.89670599 |
| 33 | Respiratory failure (HP:0002878) | 2.84606889 |
| 34 | Abnormal protein glycosylation (HP:0012346) | 2.72549115 |
| 35 | Abnormal glycosylation (HP:0012345) | 2.72549115 |
| 36 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.72549115 |
| 37 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.72549115 |
| 38 | Thrombocytosis (HP:0001894) | 2.71115022 |
| 39 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.67566305 |
| 40 | Hyperglycinemia (HP:0002154) | 2.64041282 |
| 41 | Respiratory difficulties (HP:0002880) | 2.63039992 |
| 42 | Abnormality of the labia minora (HP:0012880) | 2.59791519 |
| 43 | Rough bone trabeculation (HP:0100670) | 2.59695209 |
| 44 | Pallor (HP:0000980) | 2.57594915 |
| 45 | Petechiae (HP:0000967) | 2.56505727 |
| 46 | Failure to thrive in infancy (HP:0001531) | 2.54508885 |
| 47 | Microvesicular hepatic steatosis (HP:0001414) | 2.52991942 |
| 48 | Testicular atrophy (HP:0000029) | 2.52312085 |
| 49 | Emotional lability (HP:0000712) | 2.47873848 |
| 50 | Abnormality of glycolysis (HP:0004366) | 2.46998709 |
| 51 | Increased serum pyruvate (HP:0003542) | 2.46998709 |
| 52 | CNS hypomyelination (HP:0003429) | 2.43569404 |
| 53 | CNS demyelination (HP:0007305) | 2.41346530 |
| 54 | Poor head control (HP:0002421) | 2.35898766 |
| 55 | Premature graying of hair (HP:0002216) | 2.35051232 |
| 56 | Cerebral palsy (HP:0100021) | 2.32012461 |
| 57 | IgG deficiency (HP:0004315) | 2.31585077 |
| 58 | Generalized aminoaciduria (HP:0002909) | 2.29860674 |
| 59 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.28021907 |
| 60 | Lethargy (HP:0001254) | 2.26230699 |
| 61 | Abnormality of midbrain morphology (HP:0002418) | 2.25282002 |
| 62 | Molar tooth sign on MRI (HP:0002419) | 2.25282002 |
| 63 | Pancytopenia (HP:0001876) | 2.22929774 |
| 64 | Abnormality of the anterior horn cell (HP:0006802) | 2.22300318 |
| 65 | Degeneration of anterior horn cells (HP:0002398) | 2.22300318 |
| 66 | Cerebral edema (HP:0002181) | 2.21885333 |
| 67 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.21729623 |
| 68 | Breast hypoplasia (HP:0003187) | 2.21282019 |
| 69 | Methylmalonic acidemia (HP:0002912) | 2.19204817 |
| 70 | Multiple enchondromatosis (HP:0005701) | 2.18591424 |
| 71 | Abnormality of renal resorption (HP:0011038) | 2.18476665 |
| 72 | Secondary amenorrhea (HP:0000869) | 2.16623168 |
| 73 | Neoplasm of the adrenal gland (HP:0100631) | 2.10040011 |
| 74 | Reduced antithrombin III activity (HP:0001976) | 2.09076389 |
| 75 | Abnormality of urine glucose concentration (HP:0011016) | 2.07715291 |
| 76 | Glycosuria (HP:0003076) | 2.07715291 |
| 77 | Rhabdomyolysis (HP:0003201) | 2.07358350 |
| 78 | Medial flaring of the eyebrow (HP:0010747) | 2.07153588 |
| 79 | Abnormality of serum amino acid levels (HP:0003112) | 2.06287688 |
| 80 | Premature ovarian failure (HP:0008209) | 2.05532390 |
| 81 | Tongue fasciculations (HP:0001308) | 2.04977837 |
| 82 | 11 pairs of ribs (HP:0000878) | 2.04559315 |
| 83 | Ragged-red muscle fibers (HP:0003200) | 2.03511698 |
| 84 | Progressive inability to walk (HP:0002505) | 2.02634624 |
| 85 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.02265679 |
| 86 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.02265679 |
| 87 | Single umbilical artery (HP:0001195) | 2.02265679 |
| 88 | Progressive muscle weakness (HP:0003323) | 2.01534755 |
| 89 | Progressive microcephaly (HP:0000253) | 2.00700226 |
| 90 | Abnormal hemoglobin (HP:0011902) | 2.00597526 |
| 91 | Stomatitis (HP:0010280) | 1.99745182 |
| 92 | Abnormal trabecular bone morphology (HP:0100671) | 1.94770207 |
| 93 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.94082975 |
| 94 | Abnormality of alanine metabolism (HP:0010916) | 1.93943137 |
| 95 | Hyperalaninemia (HP:0003348) | 1.93943137 |
| 96 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.93943137 |
| 97 | Cholecystitis (HP:0001082) | 1.93908740 |
| 98 | Abnormal gallbladder physiology (HP:0012438) | 1.93908740 |
| 99 | IgM deficiency (HP:0002850) | 1.92882959 |
| 100 | Nausea (HP:0002018) | 1.92179171 |
| 101 | Congenital primary aphakia (HP:0007707) | 1.89614783 |
| 102 | Pulmonary fibrosis (HP:0002206) | 1.89279163 |
| 103 | Dicarboxylic aciduria (HP:0003215) | 1.88966189 |
| 104 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.88966189 |
| 105 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.88413486 |
| 106 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.87924980 |
| 107 | Abnormality of glycine metabolism (HP:0010895) | 1.87924980 |
| 108 | Abnormality of the umbilical cord (HP:0010881) | 1.87507901 |
| 109 | Severe combined immunodeficiency (HP:0004430) | 1.87361504 |
| 110 | Leukodystrophy (HP:0002415) | 1.86800211 |
| 111 | Bone marrow hypocellularity (HP:0005528) | 1.85889120 |
| 112 | Carpal bone hypoplasia (HP:0001498) | 1.83795913 |
| 113 | Abdominal situs inversus (HP:0003363) | 1.83205484 |
| 114 | Abnormality of abdominal situs (HP:0011620) | 1.83205484 |
| 115 | Retinal dysplasia (HP:0007973) | 1.82519830 |
| 116 | Gait imbalance (HP:0002141) | 1.80927963 |
| 117 | B lymphocytopenia (HP:0010976) | 1.79532014 |
| 118 | Abnormality of B cell number (HP:0010975) | 1.79532014 |
| 119 | Unsteady gait (HP:0002317) | 1.79045726 |
| 120 | Colon cancer (HP:0003003) | 1.78832552 |
| 121 | True hermaphroditism (HP:0010459) | 1.77738447 |
| 122 | Hyponatremia (HP:0002902) | 1.77660953 |
| 123 | Sparse eyelashes (HP:0000653) | 1.77338065 |
| 124 | Postnatal microcephaly (HP:0005484) | 1.76687341 |
| 125 | Bifid tongue (HP:0010297) | 1.74219362 |
| 126 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.71821466 |
| 127 | Hyperglycinuria (HP:0003108) | 1.70948303 |
| 128 | Nephrogenic diabetes insipidus (HP:0009806) | 1.70575911 |
| 129 | Inability to walk (HP:0002540) | 1.68913245 |
| 130 | Abnormality of secondary sexual hair (HP:0009888) | 1.68703098 |
| 131 | Abnormality of the axillary hair (HP:0100134) | 1.68703098 |
| 132 | Optic disc pallor (HP:0000543) | 1.68120500 |
| 133 | Methylmalonic aciduria (HP:0012120) | 1.68060457 |
| 134 | Absent thumb (HP:0009777) | 1.67984556 |
| 135 | Neutropenia (HP:0001875) | 1.67453494 |
| 136 | Palpitations (HP:0001962) | 1.67371195 |
| 137 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.66854573 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.16305209 |
| 2 | TAOK3 | 4.14791231 |
| 3 | VRK2 | 4.06052411 |
| 4 | NME2 | 3.59270704 |
| 5 | SRPK1 | 3.36441905 |
| 6 | STK16 | 3.34554353 |
| 7 | EIF2AK1 | 3.28612835 |
| 8 | WEE1 | 3.09003487 |
| 9 | WNK3 | 2.82804607 |
| 10 | EIF2AK3 | 2.75032393 |
| 11 | TESK2 | 2.49110541 |
| 12 | TESK1 | 2.37566255 |
| 13 | VRK1 | 2.32053696 |
| 14 | TLK1 | 2.21276697 |
| 15 | NUAK1 | 2.18245672 |
| 16 | PIM2 | 2.09283639 |
| 17 | TRIM28 | 2.00742804 |
| 18 | BCKDK | 2.00257948 |
| 19 | TSSK6 | 1.94940668 |
| 20 | BCR | 1.84835987 |
| 21 | NME1 | 1.81639640 |
| 22 | MAP3K11 | 1.75957344 |
| 23 | PLK4 | 1.72900161 |
| 24 | MYLK | 1.63690452 |
| 25 | ARAF | 1.63549584 |
| 26 | GRK6 | 1.60369345 |
| 27 | MAP4K2 | 1.55770741 |
| 28 | MAP4K1 | 1.54269547 |
| 29 | CSNK1G3 | 1.49924514 |
| 30 | SCYL2 | 1.47313274 |
| 31 | BRAF | 1.43177305 |
| 32 | TBK1 | 1.35184690 |
| 33 | IKBKE | 1.34684283 |
| 34 | LIMK1 | 1.34246862 |
| 35 | KDR | 1.32047945 |
| 36 | ZAK | 1.28885909 |
| 37 | CSNK1G2 | 1.26820662 |
| 38 | BRSK2 | 1.25299388 |
| 39 | MAP3K12 | 1.25250165 |
| 40 | TEC | 1.23708685 |
| 41 | CSNK1G1 | 1.17275211 |
| 42 | AURKA | 1.14550204 |
| 43 | CCNB1 | 1.10678216 |
| 44 | NEK1 | 1.04314900 |
| 45 | CDC7 | 1.04285910 |
| 46 | AURKB | 1.03865324 |
| 47 | NEK2 | 1.03549226 |
| 48 | CDK8 | 1.02575003 |
| 49 | MAP2K3 | 1.01114462 |
| 50 | PLK1 | 1.00920816 |
| 51 | TTK | 0.99663706 |
| 52 | OBSCN | 0.98842677 |
| 53 | CSNK1A1L | 0.97852813 |
| 54 | DAPK1 | 0.97266763 |
| 55 | ILK | 0.97140526 |
| 56 | CDK7 | 0.96237578 |
| 57 | PBK | 0.94452414 |
| 58 | STK24 | 0.92980492 |
| 59 | RPS6KB2 | 0.91672672 |
| 60 | TYK2 | 0.89848444 |
| 61 | PASK | 0.88674899 |
| 62 | MAP3K3 | 0.87581538 |
| 63 | CDK19 | 0.86104582 |
| 64 | PIK3CG | 0.85504715 |
| 65 | MAPKAPK3 | 0.84236360 |
| 66 | PAK4 | 0.80256046 |
| 67 | MAPK15 | 0.79187987 |
| 68 | GRK5 | 0.78995112 |
| 69 | MST4 | 0.78846709 |
| 70 | ACVR1B | 0.78761122 |
| 71 | EIF2AK2 | 0.77588531 |
| 72 | ZAP70 | 0.73903691 |
| 73 | BLK | 0.73644729 |
| 74 | MAP3K8 | 0.73242196 |
| 75 | GRK7 | 0.73174243 |
| 76 | CSNK2A1 | 0.72376797 |
| 77 | PAK1 | 0.71861993 |
| 78 | MAP2K7 | 0.70486089 |
| 79 | MAP2K6 | 0.69960498 |
| 80 | BTK | 0.69600393 |
| 81 | LRRK2 | 0.68364169 |
| 82 | MAPK13 | 0.65579321 |
| 83 | CSNK2A2 | 0.65521830 |
| 84 | ATR | 0.64953019 |
| 85 | RPS6KA4 | 0.64687178 |
| 86 | PIM1 | 0.63744983 |
| 87 | TAOK2 | 0.62708922 |
| 88 | BRSK1 | 0.62670299 |
| 89 | PLK3 | 0.62330310 |
| 90 | TGFBR2 | 0.61420973 |
| 91 | EPHA2 | 0.58567405 |
| 92 | IKBKB | 0.58517535 |
| 93 | MUSK | 0.58322428 |
| 94 | IRAK3 | 0.57880096 |
| 95 | CDK3 | 0.57752903 |
| 96 | PDK4 | 0.57416503 |
| 97 | PDK3 | 0.57416503 |
| 98 | PRKCQ | 0.57113704 |
| 99 | ADRBK2 | 0.57039830 |
| 100 | ATM | 0.56303315 |
| 101 | RIPK4 | 0.55783602 |
| 102 | BMPR2 | 0.55634827 |
| 103 | DYRK2 | 0.54891791 |
| 104 | IRAK4 | 0.54618360 |
| 105 | LMTK2 | 0.51127815 |
| 106 | INSRR | 0.50556835 |
| 107 | TGFBR1 | 0.49053554 |
| 108 | BMPR1B | 0.48736129 |
| 109 | PINK1 | 0.48143844 |
| 110 | STK4 | 0.47314587 |
| 111 | MAP2K2 | 0.46820946 |
| 112 | DYRK3 | 0.46644434 |
| 113 | PDK2 | 0.46257135 |
| 114 | NLK | 0.45089468 |
| 115 | RPS6KA5 | 0.44755603 |
| 116 | TXK | 0.44592812 |
| 117 | KIT | 0.43798336 |
| 118 | SYK | 0.43645059 |
| 119 | AKT3 | 0.43365243 |
| 120 | STK10 | 0.42565920 |
| 121 | MAP3K14 | 0.42484887 |
| 122 | TNIK | 0.41421767 |
| 123 | FES | 0.41302096 |
| 124 | LCK | 0.41154819 |
| 125 | GRK1 | 0.40968882 |
| 126 | LYN | 0.40090406 |
| 127 | CHEK2 | 0.37056257 |
| 128 | ABL2 | 0.36733442 |
| 129 | PHKG1 | 0.34185078 |
| 130 | PHKG2 | 0.34185078 |
| 131 | ITK | 0.33791659 |
| 132 | MAPKAPK5 | 0.33150042 |
| 133 | AKT2 | 0.31168005 |
| 134 | MAP3K7 | 0.29322455 |
| 135 | STK38L | 0.29047372 |
| 136 | TNK2 | 0.28147093 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.69743021 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.41136973 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 3.51257672 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.50759114 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.08640919 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 2.90347575 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.82912540 |
| 8 | Protein export_Homo sapiens_hsa03060 | 2.72751163 |
| 9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.60358933 |
| 10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.52244273 |
| 11 | Base excision repair_Homo sapiens_hsa03410 | 2.39996449 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 2.39668209 |
| 13 | Huntingtons disease_Homo sapiens_hsa05016 | 2.25858349 |
| 14 | Spliceosome_Homo sapiens_hsa03040 | 2.20604087 |
| 15 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.13880463 |
| 16 | RNA transport_Homo sapiens_hsa03013 | 1.95711175 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.80972972 |
| 18 | Alzheimers disease_Homo sapiens_hsa05010 | 1.78352717 |
| 19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.76915168 |
| 20 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.72973419 |
| 21 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.64318354 |
| 22 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.62697038 |
| 23 | RNA degradation_Homo sapiens_hsa03018 | 1.61149599 |
| 24 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.56863815 |
| 25 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.50102993 |
| 26 | Basal transcription factors_Homo sapiens_hsa03022 | 1.48850797 |
| 27 | Purine metabolism_Homo sapiens_hsa00230 | 1.45188820 |
| 28 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.43755950 |
| 29 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.41545006 |
| 30 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.38748365 |
| 31 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.33691539 |
| 32 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.30866026 |
| 33 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.27491429 |
| 34 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.25839011 |
| 35 | Cell cycle_Homo sapiens_hsa04110 | 1.25790681 |
| 36 | Sulfur relay system_Homo sapiens_hsa04122 | 1.24515957 |
| 37 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.21531451 |
| 38 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.17577360 |
| 39 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.09286946 |
| 40 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.05726330 |
| 41 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.01977981 |
| 42 | Other glycan degradation_Homo sapiens_hsa00511 | 0.93856538 |
| 43 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.92637524 |
| 44 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.88302885 |
| 45 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.87642683 |
| 46 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.85462655 |
| 47 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.84361834 |
| 48 | Carbon metabolism_Homo sapiens_hsa01200 | 0.83193621 |
| 49 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.83109601 |
| 50 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.81756402 |
| 51 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.80099596 |
| 52 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.79594469 |
| 53 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.76664427 |
| 54 | Metabolic pathways_Homo sapiens_hsa01100 | 0.75856599 |
| 55 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.75691461 |
| 56 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.73529911 |
| 57 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.72689458 |
| 58 | Galactose metabolism_Homo sapiens_hsa00052 | 0.70506740 |
| 59 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.68184924 |
| 60 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.65661584 |
| 61 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.65047349 |
| 62 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.64875898 |
| 63 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.62934461 |
| 64 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.61671930 |
| 65 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.61436836 |
| 66 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.58093552 |
| 67 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.57469673 |
| 68 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.56522956 |
| 69 | Legionellosis_Homo sapiens_hsa05134 | 0.56072329 |
| 70 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.53535624 |
| 71 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.52530443 |
| 72 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.52312088 |
| 73 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.49829747 |
| 74 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.49826514 |
| 75 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.49114876 |
| 76 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.49054116 |
| 77 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.48671544 |
| 78 | Allograft rejection_Homo sapiens_hsa05330 | 0.47170791 |
| 79 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.46332916 |
| 80 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.45606651 |
| 81 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.44296567 |
| 82 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.42059168 |
| 83 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.41730041 |
| 84 | Viral myocarditis_Homo sapiens_hsa05416 | 0.40587142 |
| 85 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.40418479 |
| 86 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.40408637 |
| 87 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.38547569 |
| 88 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.37902414 |
| 89 | Lysosome_Homo sapiens_hsa04142 | 0.36726236 |
| 90 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.33485468 |
| 91 | Peroxisome_Homo sapiens_hsa04146 | 0.33480341 |
| 92 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.32940316 |
| 93 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.32868523 |
| 94 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.30370808 |
| 95 | Measles_Homo sapiens_hsa05162 | 0.29650598 |
| 96 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.29553166 |
| 97 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.29527607 |
| 98 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.27501708 |
| 99 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.27399454 |
| 100 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.27367645 |
| 101 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.26848540 |
| 102 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.26021247 |
| 103 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.25726305 |
| 104 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.25425864 |
| 105 | Apoptosis_Homo sapiens_hsa04210 | 0.21907608 |
| 106 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.21874984 |
| 107 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.21742205 |
| 108 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.21448260 |
| 109 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.21104476 |
| 110 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.20323222 |
| 111 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.19926886 |
| 112 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.19870002 |
| 113 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.19643358 |
| 114 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.19566603 |
| 115 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.19408593 |
| 116 | Phototransduction_Homo sapiens_hsa04744 | 0.19336519 |
| 117 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.18383255 |
| 118 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.18064339 |
| 119 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.17422494 |
| 120 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.16082894 |
| 121 | Shigellosis_Homo sapiens_hsa05131 | 0.14972741 |
| 122 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.14193058 |
| 123 | HTLV-I infection_Homo sapiens_hsa05166 | 0.13830441 |
| 124 | Thyroid cancer_Homo sapiens_hsa05216 | 0.13254783 |

