CDR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Autoantibodies directed against the protein encoded by this intronless gene have been found in some patients with paraneoplastic cerebellar degeneration. The encoded protein contains several hexapeptide repeats. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)6.23300817
2synaptic vesicle maturation (GO:0016188)5.59265209
3neuronal action potential propagation (GO:0019227)5.58994771
4glutamate secretion (GO:0014047)5.51921219
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.35901502
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.34023967
7vocalization behavior (GO:0071625)5.24593378
8cerebellar Purkinje cell differentiation (GO:0021702)5.05037250
9L-amino acid import (GO:0043092)5.02119563
10regulation of synaptic vesicle exocytosis (GO:2000300)4.98809698
11protein localization to synapse (GO:0035418)4.88979154
12locomotory exploration behavior (GO:0035641)4.84886795
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.63861223
14neurofilament cytoskeleton organization (GO:0060052)4.58511665
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.58230057
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.52058119
17regulation of synaptic vesicle transport (GO:1902803)4.43020471
18neuron cell-cell adhesion (GO:0007158)4.32441398
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.31661701
20amino acid import (GO:0043090)4.31535242
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.29831728
22neurotransmitter secretion (GO:0007269)4.26123369
23glutamate receptor signaling pathway (GO:0007215)4.21711871
24regulation of glutamate receptor signaling pathway (GO:1900449)4.20985652
25synaptic transmission, glutamatergic (GO:0035249)4.14947524
26negative regulation of dendrite morphogenesis (GO:0050774)4.10855108
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.08286771
28neuromuscular process controlling posture (GO:0050884)4.07739506
29positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.02044047
30potassium ion homeostasis (GO:0055075)4.01937083
31neuron-neuron synaptic transmission (GO:0007270)4.01525232
32G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.98608313
33membrane depolarization during action potential (GO:0086010)3.93549057
34exploration behavior (GO:0035640)3.91571616
35regulation of neuronal synaptic plasticity (GO:0048168)3.87732189
36cellular potassium ion homeostasis (GO:0030007)3.85930278
37axon ensheathment in central nervous system (GO:0032291)3.82634280
38central nervous system myelination (GO:0022010)3.82634280
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.79843121
40innervation (GO:0060384)3.78931329
41cell migration in hindbrain (GO:0021535)3.76832229
42negative regulation of dendrite development (GO:2000171)3.76335868
43regulation of synapse structural plasticity (GO:0051823)3.75728723
44C4-dicarboxylate transport (GO:0015740)3.74641749
45potassium ion import (GO:0010107)3.73027371
46negative regulation of cytosolic calcium ion concentration (GO:0051481)3.69464383
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67379022
48positive regulation of membrane potential (GO:0045838)3.67226711
49cellular sodium ion homeostasis (GO:0006883)3.67142740
50regulation of long-term neuronal synaptic plasticity (GO:0048169)3.63976983
51neuronal ion channel clustering (GO:0045161)3.63539420
52regulation of postsynaptic membrane potential (GO:0060078)3.57535968
53gamma-aminobutyric acid transport (GO:0015812)3.55579804
54neurotransmitter-gated ion channel clustering (GO:0072578)3.55317923
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.53559754
56gamma-aminobutyric acid signaling pathway (GO:0007214)3.50967173
57serotonin metabolic process (GO:0042428)3.45882912
58neurotransmitter transport (GO:0006836)3.41800901
59membrane depolarization (GO:0051899)3.40423844
60cerebellar granule cell differentiation (GO:0021707)3.36867086
61long-term memory (GO:0007616)3.36463837
62regulation of synaptic plasticity (GO:0048167)3.35588441
63synaptic vesicle endocytosis (GO:0048488)3.34156338
64regulation of neurotransmitter secretion (GO:0046928)3.33275604
65positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.31088868
66cell communication by electrical coupling (GO:0010644)3.29271240
67membrane hyperpolarization (GO:0060081)3.28246367
68neuromuscular process controlling balance (GO:0050885)3.27835209
69cell differentiation in hindbrain (GO:0021533)3.27571173
70presynaptic membrane assembly (GO:0097105)3.26413442
71negative regulation of synaptic transmission, GABAergic (GO:0032229)3.26287180
72long-term synaptic potentiation (GO:0060291)3.25927631
73neuromuscular process (GO:0050905)3.23526095
74cAMP-mediated signaling (GO:0019933)3.23114776
75regulation of synaptic transmission, glutamatergic (GO:0051966)3.21252878
76negative regulation of neurotransmitter secretion (GO:0046929)3.20924805
77transmission of nerve impulse (GO:0019226)3.20490864
78regulation of neurotransmitter levels (GO:0001505)3.19821051
79detection of calcium ion (GO:0005513)3.19445102
80auditory behavior (GO:0031223)3.19232001
81neurotransmitter uptake (GO:0001504)3.19064625
82regulation of vesicle fusion (GO:0031338)3.18410283
83regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.16413640
84striatum development (GO:0021756)3.15988901
85response to histamine (GO:0034776)3.13075108
86positive regulation of synapse maturation (GO:0090129)3.10716237
87urinary tract smooth muscle contraction (GO:0014848)3.10639134
88regulation of voltage-gated calcium channel activity (GO:1901385)3.10355529
89adult walking behavior (GO:0007628)3.08917415
90positive regulation of potassium ion transmembrane transport (GO:1901381)3.08740234
91positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.08513652
92proline transport (GO:0015824)3.08493109
93mechanosensory behavior (GO:0007638)3.08448163
94regulation of synapse maturation (GO:0090128)3.07739479
95cell communication involved in cardiac conduction (GO:0086065)3.07011486
96neuron recognition (GO:0008038)3.06279780
97response to auditory stimulus (GO:0010996)3.06050685
98sodium ion export (GO:0071436)3.05932380
99establishment of synaptic vesicle localization (GO:0097480)3.05442733
100synaptic vesicle transport (GO:0048489)3.05442733
101synaptic transmission (GO:0007268)3.05147519
102layer formation in cerebral cortex (GO:0021819)3.02938782
103dendritic spine morphogenesis (GO:0060997)3.02582886
104regulation of neurotransmitter transport (GO:0051588)3.02541988
105presynaptic membrane organization (GO:0097090)3.02339470
106central nervous system projection neuron axonogenesis (GO:0021952)3.02065969
107organelle transport along microtubule (GO:0072384)2.99905030
108synapse assembly (GO:0007416)2.99330526
109negative regulation of neurotransmitter transport (GO:0051589)2.98185889
110regulation of sodium ion transmembrane transporter activity (GO:2000649)2.97777922
111primary amino compound metabolic process (GO:1901160)2.96848045
112vesicle transport along microtubule (GO:0047496)2.96162676
113membrane assembly (GO:0071709)2.95823118
114activation of protein kinase A activity (GO:0034199)2.95496783
115regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.94179795
116axonal fasciculation (GO:0007413)2.93800715
117postsynaptic membrane organization (GO:0001941)2.93265545
118regulation of membrane repolarization (GO:0060306)2.92588656
119dendrite morphogenesis (GO:0048813)2.92343881
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.92294206
121calcium-mediated signaling using intracellular calcium source (GO:0035584)2.89765391
122startle response (GO:0001964)2.89601201
123regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.88585493
124axon cargo transport (GO:0008088)2.87620718
125cochlea development (GO:0090102)2.87273293
126regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85968261
127chemosensory behavior (GO:0007635)2.84849766
128behavioral defense response (GO:0002209)2.84640036
129behavioral fear response (GO:0001662)2.84640036
130establishment of nucleus localization (GO:0040023)2.82167296

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.95448450
2GBX2_23144817_ChIP-Seq_PC3_Human4.35929004
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04620988
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98650195
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97418160
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54567477
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54567477
8REST_21632747_ChIP-Seq_MESCs_Mouse2.49008256
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47463022
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44615840
11DROSHA_22980978_ChIP-Seq_HELA_Human2.40192996
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.39321246
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35936479
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31380711
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29667073
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28985071
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.21691805
18TAF15_26573619_Chip-Seq_HEK293_Human2.20890801
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.16792515
20AR_21572438_ChIP-Seq_LNCaP_Human2.16451718
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.04025449
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.03749374
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.01006891
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97435858
25SMAD4_21799915_ChIP-Seq_A2780_Human1.97244141
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96490068
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.96454717
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96304712
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95272765
30IGF1R_20145208_ChIP-Seq_DFB_Human1.91239910
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91230627
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87199226
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78974899
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72541298
35P300_19829295_ChIP-Seq_ESCs_Human1.69512234
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66648365
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63995967
38NR3C1_23031785_ChIP-Seq_PC12_Mouse1.53154959
39STAT3_23295773_ChIP-Seq_U87_Human1.50755921
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50619053
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50164308
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47840850
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.45649257
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.45110469
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.45060745
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44258150
47AR_25329375_ChIP-Seq_VCAP_Human1.43580990
48ZNF274_21170338_ChIP-Seq_K562_Hela1.42527090
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40740968
50CTNNB1_20460455_ChIP-Seq_HCT116_Human1.39701308
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.39605608
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37799405
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36164283
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35695970
55* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34425648
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30366061
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30248384
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29761686
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29484825
60AR_19668381_ChIP-Seq_PC3_Human1.27850647
61TCF4_23295773_ChIP-Seq_U87_Human1.27675300
62LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27256749
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26988746
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.26151200
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25224365
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24846788
67AHR_22903824_ChIP-Seq_MCF-7_Human1.24697360
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23167882
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22806971
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22167954
71TP53_16413492_ChIP-PET_HCT116_Human1.18788740
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16359192
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.16045444
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.15864651
75BCAT_22108803_ChIP-Seq_LS180_Human1.15739494
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.15071595
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12882278
78RNF2_27304074_Chip-Seq_NSC_Mouse1.12591592
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11974571
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11736563
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11352478
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.08393517
83KDM2B_26808549_Chip-Seq_REH_Human1.08301670
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08298202
85RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07921850
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07744182
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07032756
88SOX9_26525672_Chip-Seq_HEART_Mouse1.06803781
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.06753829
90FUS_26573619_Chip-Seq_HEK293_Human1.05417082
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05219461
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04982352
93RUNX2_22187159_ChIP-Seq_PCA_Human1.04805153
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03635180
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03238932
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03067020
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02643611
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02446612
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02376487
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01490767
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00538944
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00140087
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00140087
104NANOG_18555785_Chip-Seq_ESCs_Mouse0.99671206
105TP53_18474530_ChIP-ChIP_U2OS_Human0.98871547
106SMAD3_21741376_ChIP-Seq_ESCs_Human0.98251494
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98069565
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97078635
109JUN_21703547_ChIP-Seq_K562_Human0.96518121
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.96463667
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95098194
112RING1B_27294783_Chip-Seq_NPCs_Mouse0.93024106
113RXR_22108803_ChIP-Seq_LS180_Human0.91138061

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.14839034
2MP0003880_abnormal_central_pattern4.93903849
3MP0004270_analgesia4.10194411
4MP0003635_abnormal_synaptic_transmissio3.98954657
5MP0009046_muscle_twitch3.76361472
6MP0009745_abnormal_behavioral_response3.17783859
7MP0002064_seizures3.16504760
8MP0002063_abnormal_learning/memory/cond3.08817145
9MP0002735_abnormal_chemical_nociception3.08753017
10MP0001968_abnormal_touch/_nociception3.06522257
11MP0002272_abnormal_nervous_system2.81733326
12MP0002572_abnormal_emotion/affect_behav2.72433492
13MP0002734_abnormal_mechanical_nocicepti2.69325202
14MP0001486_abnormal_startle_reflex2.61794369
15MP0002736_abnormal_nociception_after2.45694565
16MP0001501_abnormal_sleep_pattern2.38763809
17MP0002067_abnormal_sensory_capabilities2.33436084
18MP0004858_abnormal_nervous_system2.31741619
19MP0006276_abnormal_autonomic_nervous2.27905605
20MP0001440_abnormal_grooming_behavior2.20221006
21MP0002733_abnormal_thermal_nociception2.15211668
22MP0005423_abnormal_somatic_nervous2.09252774
23MP0008569_lethality_at_weaning2.05308269
24MP0002184_abnormal_innervation2.03056773
25MP0001970_abnormal_pain_threshold1.99059904
26MP0003879_abnormal_hair_cell1.92893786
27MP0001984_abnormal_olfaction1.84206501
28MP0004811_abnormal_neuron_physiology1.78791478
29MP0002822_catalepsy1.78041517
30MP0004924_abnormal_behavior1.76875941
31MP0005386_behavior/neurological_phenoty1.76875941
32MP0002557_abnormal_social/conspecific_i1.74528905
33MP0000778_abnormal_nervous_system1.67657398
34MP0002909_abnormal_adrenal_gland1.63256033
35MP0000955_abnormal_spinal_cord1.60523380
36MP0004145_abnormal_muscle_electrophysio1.59462562
37MP0003329_amyloid_beta_deposits1.57601837
38MP0000569_abnormal_digit_pigmentation1.51666852
39MP0004142_abnormal_muscle_tone1.50283436
40MP0002882_abnormal_neuron_morphology1.47814094
41MP0005646_abnormal_pituitary_gland1.43699244
42MP0003633_abnormal_nervous_system1.43338014
43MP0002066_abnormal_motor_capabilities/c1.40961516
44MP0001188_hyperpigmentation1.40575386
45MP0001502_abnormal_circadian_rhythm1.40462990
46MP0003787_abnormal_imprinting1.37557251
47MP0000751_myopathy1.25471401
48MP0002229_neurodegeneration1.25378334
49MP0003631_nervous_system_phenotype1.19460912
50MP0005551_abnormal_eye_electrophysiolog1.15829864
51MP0003122_maternal_imprinting1.13049123
52MP0009780_abnormal_chondrocyte_physiolo1.11317739
53MP0008057_abnormal_DNA_replication1.10723617
54MP0008872_abnormal_physiological_respon1.09408255
55MP0000566_synostosis1.08449353
56MP0005645_abnormal_hypothalamus_physiol1.07325418
57MP0001529_abnormal_vocalization1.06341832
58MP0004742_abnormal_vestibular_system1.04654103
59MP0004130_abnormal_muscle_cell1.03167690
60MP0004215_abnormal_myocardial_fiber1.00811115
61MP0002152_abnormal_brain_morphology1.00610035
62MP0001905_abnormal_dopamine_level0.99342772
63MP0008874_decreased_physiological_sensi0.98054054
64MP0001963_abnormal_hearing_physiology0.97486955
65MP0005187_abnormal_penis_morphology0.94970949
66MP0001485_abnormal_pinna_reflex0.94510951
67MP0004085_abnormal_heartbeat0.92816505
68MP0001986_abnormal_taste_sensitivity0.91197207
69MP0004147_increased_porphyrin_level0.90679834
70MP0002752_abnormal_somatic_nervous0.90253112
71MP0003183_abnormal_peptide_metabolism0.84333733
72MP0003646_muscle_fatigue0.83153474
73MP0003868_abnormal_feces_composition0.80627452
74MP0004885_abnormal_endolymph0.80277586
75MP0004233_abnormal_muscle_weight0.80116997
76MP0003045_fibrosis0.79456444
77MP0002069_abnormal_eating/drinking_beha0.79318854
78MP0003634_abnormal_glial_cell0.78688545
79MP0003632_abnormal_nervous_system0.78399050
80MP0001299_abnormal_eye_distance/0.76961371
81MP0008877_abnormal_DNA_methylation0.76584457
82MP0000026_abnormal_inner_ear0.74557329
83MP0004043_abnormal_pH_regulation0.73834033
84MP0010386_abnormal_urinary_bladder0.72371787
85MP0002837_dystrophic_cardiac_calcinosis0.72207920
86MP0005535_abnormal_body_temperature0.71418999
87MP0005623_abnormal_meninges_morphology0.70317389
88MP0003137_abnormal_impulse_conducting0.67978299
89MP0003121_genomic_imprinting0.67466214
90MP0002751_abnormal_autonomic_nervous0.67080772
91MP0004484_altered_response_of0.66431124
92MP0005499_abnormal_olfactory_system0.66296526
93MP0005394_taste/olfaction_phenotype0.66296526
94MP0003861_abnormal_nervous_system0.65938697
95MP0005409_darkened_coat_color0.65576644
96MP0004036_abnormal_muscle_relaxation0.65362230
97MP0000604_amyloidosis0.65309425
98MP0008004_abnormal_stomach_pH0.63606081
99MP0003890_abnormal_embryonic-extraembry0.62598586
100MP0000920_abnormal_myelination0.61903955
101MP0000749_muscle_degeneration0.60949003
102MP0001348_abnormal_lacrimal_gland0.59950631
103MP0002638_abnormal_pupillary_reflex0.57339454
104MP0003690_abnormal_glial_cell0.57304577
105MP0001177_atelectasis0.57264604
106MP0001943_abnormal_respiration0.56970162
107MP0010769_abnormal_survival0.56243699
108MP0002876_abnormal_thyroid_physiology0.55446704
109MP0002082_postnatal_lethality0.55039220
110MP0010770_preweaning_lethality0.55039220
111MP0005670_abnormal_white_adipose0.54275115
112MP0000631_abnormal_neuroendocrine_gland0.53893586
113MP0002249_abnormal_larynx_morphology0.53215180
114MP0010768_mortality/aging0.52650112
115MP0005253_abnormal_eye_physiology0.51005951
116MP0003938_abnormal_ear_development0.49925210
117MP0005174_abnormal_tail_pigmentation0.48599039
118MP0003123_paternal_imprinting0.48058051
119MP0003956_abnormal_body_size0.46917937
120MP0005666_abnormal_adipose_tissue0.45216720

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.26600115
2Myokymia (HP:0002411)7.33690358
3Focal seizures (HP:0007359)6.08581199
4Febrile seizures (HP:0002373)5.82265283
5Progressive cerebellar ataxia (HP:0002073)5.55940616
6Atonic seizures (HP:0010819)5.35250017
7Epileptic encephalopathy (HP:0200134)5.34715958
8Absence seizures (HP:0002121)4.66514955
9Action tremor (HP:0002345)4.56251742
10Gaze-evoked nystagmus (HP:0000640)4.25901259
11Dialeptic seizures (HP:0011146)4.15098213
12Generalized tonic-clonic seizures (HP:0002069)4.11639337
13Genetic anticipation (HP:0003743)4.10006835
14Visual hallucinations (HP:0002367)3.84786016
15Scanning speech (HP:0002168)3.83794566
16Truncal ataxia (HP:0002078)3.76559627
17Impaired vibration sensation in the lower limbs (HP:0002166)3.59868586
18Hyperventilation (HP:0002883)3.50769535
19Ulnar claw (HP:0001178)3.39073457
20Supranuclear gaze palsy (HP:0000605)3.25322521
21Broad-based gait (HP:0002136)3.24275981
22Urinary bladder sphincter dysfunction (HP:0002839)3.21658817
23Dysmetria (HP:0001310)3.16637601
24Dysmetric saccades (HP:0000641)3.10747594
25Impaired smooth pursuit (HP:0007772)3.07136120
26Dysdiadochokinesis (HP:0002075)3.04499685
27Pheochromocytoma (HP:0002666)2.96327405
28Protruding tongue (HP:0010808)2.84655910
29Depression (HP:0000716)2.83857958
30Amblyopia (HP:0000646)2.82956719
31Insidious onset (HP:0003587)2.82647480
32Termporal pattern (HP:0011008)2.82647480
33Poor eye contact (HP:0000817)2.79333764
34Urinary urgency (HP:0000012)2.77154103
35Abnormal social behavior (HP:0012433)2.72291059
36Impaired social interactions (HP:0000735)2.72291059
37Hemiplegia (HP:0002301)2.68835518
38Anxiety (HP:0000739)2.63690961
39Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.63606807
40Epileptiform EEG discharges (HP:0011182)2.61692835
41Abnormality of ocular smooth pursuit (HP:0000617)2.61000238
42Impaired vibratory sensation (HP:0002495)2.60348186
43Neuroendocrine neoplasm (HP:0100634)2.59809867
44Ankle clonus (HP:0011448)2.56204736
45Status epilepticus (HP:0002133)2.54628424
46Abnormal eating behavior (HP:0100738)2.54483204
47Agitation (HP:0000713)2.53942454
48Specific learning disability (HP:0001328)2.48397170
49Spastic gait (HP:0002064)2.48023829
50Absent speech (HP:0001344)2.46276310
51Postural instability (HP:0002172)2.45821239
52Abnormality of the lower motor neuron (HP:0002366)2.45525633
53Abnormality of the corticospinal tract (HP:0002492)2.43301812
54EEG with generalized epileptiform discharges (HP:0011198)2.41482387
55Excessive salivation (HP:0003781)2.40718879
56Drooling (HP:0002307)2.40718879
57Obstructive sleep apnea (HP:0002870)2.35693781
58Limb dystonia (HP:0002451)2.34703790
59Megalencephaly (HP:0001355)2.31535100
60Hemiparesis (HP:0001269)2.28318539
61Inability to walk (HP:0002540)2.26625179
62Increased circulating renin level (HP:0000848)2.22164733
63Stereotypic behavior (HP:0000733)2.20821099
64Neurofibrillary tangles (HP:0002185)2.20790820
65Hammertoe (HP:0001765)2.15661282
66Hypsarrhythmia (HP:0002521)2.14047779
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.13125028
68Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13125028
69Torticollis (HP:0000473)2.13042622
70Ventricular fibrillation (HP:0001663)2.10427967
71Gait imbalance (HP:0002141)2.09947699
72Abnormal ciliary motility (HP:0012262)2.09919943
73Incomplete penetrance (HP:0003829)2.09244697
74Abnormal respiratory motile cilium physiology (HP:0012261)2.08526837
75Bradykinesia (HP:0002067)2.06965519
76Focal dystonia (HP:0004373)2.05865952
77Spastic tetraplegia (HP:0002510)2.04596522
78Sleep apnea (HP:0010535)2.04592426
79Exotropia (HP:0000577)1.99097040
80Hepatoblastoma (HP:0002884)1.98590130
81Abnormality of saccadic eye movements (HP:0000570)1.96295526
82Gait ataxia (HP:0002066)1.95522898
83Progressive inability to walk (HP:0002505)1.93983353
84Widely spaced teeth (HP:0000687)1.93913431
85Metaphyseal dysplasia (HP:0100255)1.92413881
86Thickened helices (HP:0000391)1.90533743
87Steppage gait (HP:0003376)1.90362797
88Cerebral inclusion bodies (HP:0100314)1.89724922
89Congenital primary aphakia (HP:0007707)1.89543263
90Abnormal hair whorl (HP:0010721)1.89028140
91Peripheral hypomyelination (HP:0007182)1.88858656
92Mutism (HP:0002300)1.88585355
93Prolonged QT interval (HP:0001657)1.88269059
94Blue irides (HP:0000635)1.87648807
95Lower limb muscle weakness (HP:0007340)1.87573458
96Abnormality of the labia minora (HP:0012880)1.86942038
97Alacrima (HP:0000522)1.86521284
98Agnosia (HP:0010524)1.86215057
99Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.85611202
100Generalized myoclonic seizures (HP:0002123)1.85351771
101Bradycardia (HP:0001662)1.84957156
102Fetal akinesia sequence (HP:0001989)1.84474443
103Decreased motor nerve conduction velocity (HP:0003431)1.83985381
104Abnormal EKG (HP:0003115)1.83604282
105Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83452915
106Papillary thyroid carcinoma (HP:0002895)1.82634868
107Medial flaring of the eyebrow (HP:0010747)1.81886215
108Abnormality of salivation (HP:0100755)1.81146220
109Inappropriate behavior (HP:0000719)1.80977803
110Dynein arm defect of respiratory motile cilia (HP:0012255)1.80627322
111Absent/shortened dynein arms (HP:0200106)1.80627322
112Aqueductal stenosis (HP:0002410)1.80561179
113Papilledema (HP:0001085)1.80244118
114Intention tremor (HP:0002080)1.79195992
115Syncope (HP:0001279)1.78519879
116Diplopia (HP:0000651)1.77815662
117Abnormality of binocular vision (HP:0011514)1.77815662
118Craniofacial dystonia (HP:0012179)1.76631194
119Aplasia involving bones of the upper limbs (HP:0009823)1.76624740
120Aplasia of the phalanges of the hand (HP:0009802)1.76624740
121Aplasia involving bones of the extremities (HP:0009825)1.76624740
122Polyphagia (HP:0002591)1.76118425
123Nephrogenic diabetes insipidus (HP:0009806)1.75895726
124Generalized hypopigmentation of hair (HP:0011358)1.74014441
125Morphological abnormality of the pyramidal tract (HP:0002062)1.70360690
126Astrocytoma (HP:0009592)1.69411896
127Abnormality of the astrocytes (HP:0100707)1.69411896
128Gastroesophageal reflux (HP:0002020)1.69392142
129Clumsiness (HP:0002312)1.68817751
130Decreased lacrimation (HP:0000633)1.67278131
131Bronchomalacia (HP:0002780)1.66739253
132Overgrowth (HP:0001548)1.65878021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.19758214
2MAP3K93.76496694
3MAP3K43.48204358
4MINK13.14994399
5MAP2K72.94848106
6EPHA42.84811216
7CASK2.55228157
8MAP3K122.52599192
9TNIK2.33509037
10MAP2K42.29418057
11PAK62.20541893
12CAMKK22.14632814
13CDK192.01242375
14LMTK21.88818437
15MARK11.87945786
16NTRK21.71574801
17CAMKK11.69609819
18SIK31.69068446
19DAPK11.69024917
20MAPK131.68388266
21DAPK21.60568702
22KSR21.58851577
23PNCK1.51981598
24LATS21.50551901
25RIPK41.49042928
26KSR11.44365343
27PRKCG1.39898986
28NTRK11.35279312
29CDK51.34993284
30STK381.31254614
31SGK21.29836775
32SGK2231.19381276
33SGK4941.19381276
34CAMK2A1.15737080
35PHKG11.15390818
36PHKG21.15390818
37FRK1.15236574
38PRPF4B1.14375514
39PIK3CA1.12427199
40AKT31.09680950
41CSNK1A1L1.05969005
42PLK21.04411571
43OXSR11.01452950
44MAPKAPK31.00519821
45ARAF0.99009590
46CAMK1D0.98951418
47FES0.95443761
48CDK30.95124312
49SGK30.94693020
50CAMK10.92936139
51WNK10.90021688
52UHMK10.89713815
53TAOK10.89127700
54MAP3K20.88602364
55CDK180.86989383
56GRK50.86227605
57FGFR20.83079845
58CDK140.80701685
59BCR0.79705003
60PKN10.79319115
61CAMK2B0.78695256
62CDK150.78290301
63RET0.77234574
64PDGFRB0.75616435
65CAMK1G0.74575731
66BMPR20.74458569
67WNK30.73454458
68NEK10.73220625
69PTK2B0.73171734
70FER0.72288592
71PAK30.72140676
72MET0.69479564
73SIK20.69121742
74SGK10.68060116
75CDC42BPA0.67546812
76PDK10.66835630
77CDK11A0.66806823
78STK110.64848599
79MAP3K130.64842292
80BRAF0.63647643
81MAPK120.63409953
82CAMK2D0.62787263
83STK390.61040045
84PDPK10.60802244
85CSNK1D0.60710697
86CSNK1G10.60591230
87DYRK1A0.59970320
88TYRO30.56689732
89DMPK0.56305361
90TNK20.55372984
91RAF10.54265636
92CSNK1G30.54038734
93RPS6KA30.53921402
94PRKCH0.53615178
95CAMK40.53345203
96WNK40.52576046
97LATS10.52420271
98CAMK2G0.51639571
99PRKCE0.50947600
100MAP2K10.49138467
101PRKD30.48930255
102CSNK1G20.48749452
103MAP3K10.47511715
104SCYL20.47499908
105PINK10.44905759
106CSNK1E0.43558988
107NEK60.43258535
108CCNB10.42263003
109LIMK10.41023135
110GSK3B0.40499765
111RPS6KB10.40352361
112MAPK100.40080100
113PRKG10.39776407
114MARK20.39510257
115NME10.39351144
116PRKCB0.39266178
117STK38L0.36795360
118MAP3K70.36692435
119PRKACB0.36071741
120ADRBK10.35129717
121CSNK1A10.34991856
122PRKCZ0.34428498
123FYN0.33854493
124PRKACA0.33794745
125BRD40.31808446

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.96588003
2Synaptic vesicle cycle_Homo sapiens_hsa047213.62822994
3Circadian entrainment_Homo sapiens_hsa047132.83648125
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70370163
5Long-term potentiation_Homo sapiens_hsa047202.68160434
6Glutamatergic synapse_Homo sapiens_hsa047242.56558879
7GABAergic synapse_Homo sapiens_hsa047272.54823851
8Olfactory transduction_Homo sapiens_hsa047402.53158720
9Amphetamine addiction_Homo sapiens_hsa050312.43071363
10Morphine addiction_Homo sapiens_hsa050322.36087790
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.34569198
12Salivary secretion_Homo sapiens_hsa049702.23181172
13Dopaminergic synapse_Homo sapiens_hsa047282.18542687
14Insulin secretion_Homo sapiens_hsa049112.12961102
15Taste transduction_Homo sapiens_hsa047421.98476712
16Cholinergic synapse_Homo sapiens_hsa047251.88682127
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80346309
18Serotonergic synapse_Homo sapiens_hsa047261.74583528
19Renin secretion_Homo sapiens_hsa049241.69799672
20Gastric acid secretion_Homo sapiens_hsa049711.69774807
21Long-term depression_Homo sapiens_hsa047301.69363407
22Oxytocin signaling pathway_Homo sapiens_hsa049211.66866799
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63982259
24Calcium signaling pathway_Homo sapiens_hsa040201.63877354
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63034966
26Collecting duct acid secretion_Homo sapiens_hsa049661.58988186
27Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.45121909
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43138306
29Cocaine addiction_Homo sapiens_hsa050301.42316416
30GnRH signaling pathway_Homo sapiens_hsa049121.41029401
31Type II diabetes mellitus_Homo sapiens_hsa049301.29618499
32cAMP signaling pathway_Homo sapiens_hsa040241.28090104
33Gap junction_Homo sapiens_hsa045401.26799338
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25253046
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22973313
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21616197
37Cardiac muscle contraction_Homo sapiens_hsa042601.18355050
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17634389
39Fatty acid biosynthesis_Homo sapiens_hsa000611.11912065
40ErbB signaling pathway_Homo sapiens_hsa040121.09187551
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02846686
42cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99559909
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99324177
44Dorso-ventral axis formation_Homo sapiens_hsa043200.97845274
45Axon guidance_Homo sapiens_hsa043600.96609166
46Estrogen signaling pathway_Homo sapiens_hsa049150.94954642
47Glioma_Homo sapiens_hsa052140.94725898
48Circadian rhythm_Homo sapiens_hsa047100.87633951
49Pancreatic secretion_Homo sapiens_hsa049720.87572010
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.87476867
51Oocyte meiosis_Homo sapiens_hsa041140.86123301
52Vibrio cholerae infection_Homo sapiens_hsa051100.84337775
53Melanogenesis_Homo sapiens_hsa049160.82855508
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75758124
55MAPK signaling pathway_Homo sapiens_hsa040100.74977137
56Dilated cardiomyopathy_Homo sapiens_hsa054140.72647655
57Glucagon signaling pathway_Homo sapiens_hsa049220.71790786
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.65622448
59Choline metabolism in cancer_Homo sapiens_hsa052310.65337841
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.65179514
61Thyroid hormone synthesis_Homo sapiens_hsa049180.65111498
62Phototransduction_Homo sapiens_hsa047440.63946105
63Ras signaling pathway_Homo sapiens_hsa040140.61006421
64Inositol phosphate metabolism_Homo sapiens_hsa005620.59923713
65Alzheimers disease_Homo sapiens_hsa050100.59060875
66VEGF signaling pathway_Homo sapiens_hsa043700.56393711
67Mineral absorption_Homo sapiens_hsa049780.56161181
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54753366
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53915612
70Nitrogen metabolism_Homo sapiens_hsa009100.52371131
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52289248
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51531183
73Rap1 signaling pathway_Homo sapiens_hsa040150.50734741
74beta-Alanine metabolism_Homo sapiens_hsa004100.50463049
75Hippo signaling pathway_Homo sapiens_hsa043900.49394018
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49235485
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48922421
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48846736
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47605420
80mTOR signaling pathway_Homo sapiens_hsa041500.46815815
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45916589
82Insulin signaling pathway_Homo sapiens_hsa049100.45001911
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.44813882
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44523175
85Histidine metabolism_Homo sapiens_hsa003400.42142926
86Oxidative phosphorylation_Homo sapiens_hsa001900.41821265
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41091999
88Hedgehog signaling pathway_Homo sapiens_hsa043400.40825171
89Bile secretion_Homo sapiens_hsa049760.40446505
90Endocytosis_Homo sapiens_hsa041440.40207136
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40169536
92Tight junction_Homo sapiens_hsa045300.38876051
93Wnt signaling pathway_Homo sapiens_hsa043100.37487343
94Ovarian steroidogenesis_Homo sapiens_hsa049130.36063927
95Renal cell carcinoma_Homo sapiens_hsa052110.33516487
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33454618
97Prion diseases_Homo sapiens_hsa050200.33172384
98African trypanosomiasis_Homo sapiens_hsa051430.32344466
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29795341
100Alcoholism_Homo sapiens_hsa050340.29491121
101Huntingtons disease_Homo sapiens_hsa050160.29360908
102Glycerolipid metabolism_Homo sapiens_hsa005610.29018730
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28567069
104Colorectal cancer_Homo sapiens_hsa052100.27335044
105Parkinsons disease_Homo sapiens_hsa050120.26816889
106FoxO signaling pathway_Homo sapiens_hsa040680.26323766
107AMPK signaling pathway_Homo sapiens_hsa041520.26299872
108Endometrial cancer_Homo sapiens_hsa052130.26181073
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25275310
110Adherens junction_Homo sapiens_hsa045200.24126927
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24105738
112Prolactin signaling pathway_Homo sapiens_hsa049170.23985576
113PPAR signaling pathway_Homo sapiens_hsa033200.23873763
114Melanoma_Homo sapiens_hsa052180.23052772
115Protein digestion and absorption_Homo sapiens_hsa049740.22751391
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22431240

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »