CDRT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.10315267
2sperm motility (GO:0030317)8.09279186
3acrosome reaction (GO:0007340)7.96336143
4axonemal dynein complex assembly (GO:0070286)7.83512559
5motile cilium assembly (GO:0044458)7.51897595
6fusion of sperm to egg plasma membrane (GO:0007342)6.97924069
7multicellular organism reproduction (GO:0032504)6.38920299
8cilium or flagellum-dependent cell motility (GO:0001539)6.23762719
9sperm capacitation (GO:0048240)5.96306293
10spermatid development (GO:0007286)5.94229293
11sperm-egg recognition (GO:0035036)5.81603009
12epithelial cilium movement (GO:0003351)5.66150496
13binding of sperm to zona pellucida (GO:0007339)5.62562599
14cilium movement (GO:0003341)5.46316254
15regulation of cilium movement (GO:0003352)5.15469533
16protein polyglutamylation (GO:0018095)5.14077300
17plasma membrane fusion (GO:0045026)5.09296200
18reproduction (GO:0000003)5.07694081
19cell-cell recognition (GO:0009988)4.86655949
20single strand break repair (GO:0000012)4.82078592
21microtubule depolymerization (GO:0007019)4.60906963
22single fertilization (GO:0007338)4.41891740
23protein targeting to Golgi (GO:0000042)4.28537246
24DNA packaging (GO:0006323)4.26511598
25chromosome condensation (GO:0030261)4.17211718
26establishment of protein localization to Golgi (GO:0072600)4.03481850
27phosphatidylethanolamine biosynthetic process (GO:0006646)4.01985628
28retrograde transport, vesicle recycling within Golgi (GO:0000301)4.00153763
29coenzyme catabolic process (GO:0009109)3.98871096
30rRNA methylation (GO:0031167)3.95707390
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.95326508
32spermatid nucleus differentiation (GO:0007289)3.92858603
33microtubule polymerization or depolymerization (GO:0031109)3.89377884
34phosphatidylethanolamine metabolic process (GO:0046337)3.88490266
35positive regulation of glycolytic process (GO:0045821)3.85770982
36regulation of transcription involved in cell fate commitment (GO:0060850)3.80805341
37cellular ketone body metabolic process (GO:0046950)3.76750142
38ventricular system development (GO:0021591)3.73583516
39organic cation transport (GO:0015695)3.72535072
40calcium ion-dependent exocytosis (GO:0017156)3.70864726
41spermatogenesis (GO:0007283)3.63527396
42male gamete generation (GO:0048232)3.63489337
43centriole assembly (GO:0098534)3.59547754
44regulation of Rab GTPase activity (GO:0032313)3.56336854
45positive regulation of Rab GTPase activity (GO:0032851)3.56336854
46microtubule severing (GO:0051013)3.54743389
47male meiosis (GO:0007140)3.51911836
48hemidesmosome assembly (GO:0031581)3.49591482
49cartilage morphogenesis (GO:0060536)3.43331803
50fertilization (GO:0009566)3.42622149
51intraciliary transport (GO:0042073)3.40226519
52centriole replication (GO:0007099)3.39756898
53left/right axis specification (GO:0070986)3.38823240
54negative regulation of inclusion body assembly (GO:0090084)3.38360557
55cilium organization (GO:0044782)3.36834091
56cilium assembly (GO:0042384)3.34160219
57rRNA modification (GO:0000154)3.34030088
58gamete generation (GO:0007276)3.33702421
59embryonic forelimb morphogenesis (GO:0035115)3.30944405
60germ cell development (GO:0007281)3.26556470
61ketone body metabolic process (GO:1902224)3.20530194
62peptidyl-tyrosine autophosphorylation (GO:0038083)3.17793705
63axoneme assembly (GO:0035082)3.17108498
64bundle of His cell to Purkinje myocyte communication (GO:0086069)3.16210535
65desmosome organization (GO:0002934)3.13021123
66histone mRNA catabolic process (GO:0071044)3.10691952
67Golgi to endosome transport (GO:0006895)3.09906932
68regulation of hippo signaling (GO:0035330)3.06728836
69cellular process involved in reproduction in multicellular organism (GO:0022412)3.06137516
70regulation of female gonad development (GO:2000194)3.04262742
71regulation of centriole replication (GO:0046599)3.02123713
72ribosome assembly (GO:0042255)2.88541928
73detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.85576645
74protein localization to Golgi apparatus (GO:0034067)2.85079585
75regulation of phosphoprotein phosphatase activity (GO:0043666)2.83070511
76organ growth (GO:0035265)2.80231690
77microtubule nucleation (GO:0007020)2.79873687
78aminoglycoside antibiotic metabolic process (GO:0030647)2.79031151
79forelimb morphogenesis (GO:0035136)2.77371948
80musculoskeletal movement (GO:0050881)2.76835779
81multicellular organismal movement (GO:0050879)2.76835779
82keratinization (GO:0031424)2.75128456
83histone exchange (GO:0043486)2.70565043
84keratinocyte proliferation (GO:0043616)2.65157097
85multicellular organismal reproductive process (GO:0048609)2.64825069
86cilium morphogenesis (GO:0060271)2.63661957
87polyamine biosynthetic process (GO:0006596)2.62476998
88male sex determination (GO:0030238)2.62476384
89carnitine transmembrane transport (GO:1902603)2.57024034
90carnitine shuttle (GO:0006853)2.55783097
91pattern specification involved in kidney development (GO:0061004)2.55478701
92regulation of microtubule-based movement (GO:0060632)2.55235453
93seminiferous tubule development (GO:0072520)2.53976441
94negative regulation of complement activation (GO:0045916)2.52983281
95cellular component assembly involved in morphogenesis (GO:0010927)2.50916000
96terpenoid biosynthetic process (GO:0016114)2.50508273
97kidney mesenchyme development (GO:0072074)2.49292100
98mitochondrial fission (GO:0000266)2.49239782
99male meiosis I (GO:0007141)2.47691604
100amino-acid betaine transport (GO:0015838)2.45260586

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.86139469
2STAT6_21828071_ChIP-Seq_BEAS2B_Human2.68702713
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.58388182
4ESR1_20079471_ChIP-ChIP_T-47D_Human2.56496731
5ZNF274_21170338_ChIP-Seq_K562_Hela2.53284057
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.46793210
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33989205
8ER_23166858_ChIP-Seq_MCF-7_Human2.30501752
9* CJUN_26792858_Chip-Seq_BT549_Human2.20287900
10ARNT_22903824_ChIP-Seq_MCF-7_Human2.19923214
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14131292
12CBP_20019798_ChIP-Seq_JUKART_Human2.09771812
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.09771812
14GATA1_22025678_ChIP-Seq_K562_Human2.04426971
15TAF15_26573619_Chip-Seq_HEK293_Human1.92984962
16AHR_22903824_ChIP-Seq_MCF-7_Human1.91746868
17AR_21572438_ChIP-Seq_LNCaP_Human1.84387387
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.82527324
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82509642
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81614299
21TP53_18474530_ChIP-ChIP_U2OS_Human1.80560305
22WDR5_24793694_ChIP-Seq_LNCAP_Human1.75114284
23FUS_26573619_Chip-Seq_HEK293_Human1.71984066
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71141256
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70956372
26GBX2_23144817_ChIP-Seq_PC3_Human1.70291388
27VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.68811637
28AR_25329375_ChIP-Seq_VCAP_Human1.66675844
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66018473
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63476090
31RAC3_21632823_ChIP-Seq_H3396_Human1.62066141
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61016535
33SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61016535
34RXR_22108803_ChIP-Seq_LS180_Human1.60849874
35JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60125228
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59872209
37PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.59416433
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.59353821
39* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.53993319
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53563710
41NANOG_20526341_ChIP-Seq_ESCs_Human1.50177081
42MYC_19829295_ChIP-Seq_ESCs_Human1.50136748
43* ERA_21632823_ChIP-Seq_H3396_Human1.49593554
44TP63_23658742_ChIP-Seq_EP156T_Human1.48658980
45* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48132992
46JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45296059
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45126608
48RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.43627549
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.43367530
50SMAD4_21741376_ChIP-Seq_EPCs_Human1.41131414
51EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.39592536
52HOXB7_26014856_ChIP-Seq_BT474_Human1.39353803
53STAT3_23295773_ChIP-Seq_U87_Human1.39082314
54SMAD4_21799915_ChIP-Seq_A2780_Human1.37406034
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.36070407
56E2F1_20622854_ChIP-Seq_HELA_Human1.35990644
57DROSHA_22980978_ChIP-Seq_HELA_Human1.35907162
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34407071
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33312764
60* KLF5_25053715_ChIP-Seq_YYC3_Human1.31010556
61RUNX2_22187159_ChIP-Seq_PCA_Human1.29783095
62TP63_22573176_ChIP-Seq_HFKS_Human1.28893262
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.27780693
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27018971
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26708073
66TBL1_22424771_ChIP-Seq_293T_Human1.26144335
67OCT4_20526341_ChIP-Seq_ESCs_Human1.25995971
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.25526273
69SMC4_20622854_ChIP-Seq_HELA_Human1.25041685
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.24179442
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22261010
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20879948
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20879948
74P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19834319
75PHF8_20622853_ChIP-Seq_HELA_Human1.17880654
76ERG_20517297_ChIP-Seq_VCAP_Human1.17332081
77HNFA_21074721_ChIP-Seq_CACO-2_Human1.17309997
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16877895
79P300_19829295_ChIP-Seq_ESCs_Human1.16834766
80* PHF8_20622854_ChIP-Seq_HELA_Human1.16776100
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14624629
82CEBPB_22108803_ChIP-Seq_LS180_Human1.13960520
83NANOG_19829295_ChIP-Seq_ESCs_Human1.12818852
84SOX2_19829295_ChIP-Seq_ESCs_Human1.12818852
85CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.12081628
86ETV1_20927104_ChIP-Seq_GIST48_Human1.11797392
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11578447
88CBP_21632823_ChIP-Seq_H3396_Human1.09620747
89P53_21459846_ChIP-Seq_SAOS-2_Human1.08152271
90RBPJ_21746931_ChIP-Seq_IB4_Human1.07696413
91TCF4_18268006_ChIP-ChIP_LS174T_Human1.07293388
92E2F1_17053090_ChIP-ChIP_MCF-7_Human1.07177030
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.07022319
94NCOR_22424771_ChIP-Seq_293T_Human1.06958900
95P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.06891847
96CTCF_27219007_Chip-Seq_Bcells_Human1.05921022
97BCAT_22108803_ChIP-Seq_LS180_Human1.05767733
98CDX2_22108803_ChIP-Seq_LS180_Human1.05155456
99NFYA_21822215_ChIP-Seq_K562_Human1.04791384
100FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04557070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.23571200
2MP0000579_abnormal_nail_morphology4.85166944
3MP0003950_abnormal_plasma_membrane3.87588274
4MP0003646_muscle_fatigue3.68545456
5MP0002282_abnormal_trachea_morphology3.10339438
6MP0010234_abnormal_vibrissa_follicle2.55080546
7MP0002249_abnormal_larynx_morphology2.53302252
8MP0010368_abnormal_lymphatic_system2.50758317
9MP0003698_abnormal_male_reproductive2.40646225
10MP0005275_abnormal_skin_tensile2.36075692
11MP0000751_myopathy2.29237147
12MP0001929_abnormal_gametogenesis2.18730058
13MP0001879_abnormal_lymphatic_vessel2.13565381
14MP0001348_abnormal_lacrimal_gland2.13562852
15MP0005377_hearing/vestibular/ear_phenot1.98961496
16MP0003878_abnormal_ear_physiology1.98961496
17MP0005248_abnormal_Harderian_gland1.92214897
18MP0004272_abnormal_basement_membrane1.91658484
19MP0003045_fibrosis1.84340722
20MP0008004_abnormal_stomach_pH1.83571497
21MP0009780_abnormal_chondrocyte_physiolo1.81458946
22MP0008875_abnormal_xenobiotic_pharmacok1.75430781
23MP0002234_abnormal_pharynx_morphology1.67973010
24MP0002796_impaired_skin_barrier1.62496495
25MP0000678_abnormal_parathyroid_gland1.61562567
26MP0000762_abnormal_tongue_morphology1.60887001
27MP0000749_muscle_degeneration1.60405837
28MP0000733_abnormal_muscle_development1.58945366
29MP0002332_abnormal_exercise_endurance1.55843238
30MP0005670_abnormal_white_adipose1.55444517
31MP0004264_abnormal_extraembryonic_tissu1.52636747
32MP0003718_maternal_effect1.47847393
33MP0000467_abnormal_esophagus_morphology1.47458003
34MP0004233_abnormal_muscle_weight1.46554654
35MP0005360_urolithiasis1.43931270
36MP0002168_other_aberrant_phenotype1.42733056
37MP0005395_other_phenotype1.41981332
38MP0004782_abnormal_surfactant_physiolog1.41858763
39MP0002161_abnormal_fertility/fecundity1.37212070
40MP0003315_abnormal_perineum_morphology1.32664529
41MP0002127_abnormal_cardiovascular_syste1.26294235
42MP0002060_abnormal_skin_morphology1.23202605
43MP0010678_abnormal_skin_adnexa1.22785720
44MP0002295_abnormal_pulmonary_circulatio1.21686171
45MP0005501_abnormal_skin_physiology1.15048166
46MP0000427_abnormal_hair_cycle1.14853798
47MP0002098_abnormal_vibrissa_morphology1.13603670
48MP0002160_abnormal_reproductive_system1.12492652
49MP0004084_abnormal_cardiac_muscle1.11759401
50MP0003942_abnormal_urinary_system1.11376202
51MP0003693_abnormal_embryo_hatching1.11096243
52MP0008438_abnormal_cutaneous_collagen1.10611594
53MP0003937_abnormal_limbs/digits/tail_de1.09446513
54MP0002210_abnormal_sex_determination1.06205747
55MP0001849_ear_inflammation1.06175037
56MP0009697_abnormal_copulation1.04182960
57MP0004215_abnormal_myocardial_fiber1.00206726
58MP0000750_abnormal_muscle_regeneration1.00047871
59MP0001661_extended_life_span0.96878094
60MP0002108_abnormal_muscle_morphology0.95251633
61MP0000383_abnormal_hair_follicle0.93996452
62MP0001216_abnormal_epidermal_layer0.92362019
63MP0004484_altered_response_of0.92343433
64MP0010771_integument_phenotype0.90050870
65MP0005365_abnormal_bile_salt0.89410437
66MP0004085_abnormal_heartbeat0.89042879
67MP0000653_abnormal_sex_gland0.88298634
68MP0009053_abnormal_anal_canal0.87780050
69MP0005647_abnormal_sex_gland0.87318552
70MP0004036_abnormal_muscle_relaxation0.85146184
71MP0005330_cardiomyopathy0.82775091
72MP0005266_abnormal_metabolism0.82770608
73MP0003755_abnormal_palate_morphology0.81032872
74MP0005253_abnormal_eye_physiology0.79175832
75MP0000537_abnormal_urethra_morphology0.79054661
76MP0002138_abnormal_hepatobiliary_system0.77911549
77MP0000759_abnormal_skeletal_muscle0.77695928
78MP0001145_abnormal_male_reproductive0.77518910
79MP0005084_abnormal_gallbladder_morpholo0.77099330
80MP0006138_congestive_heart_failure0.76260346
81MP0005623_abnormal_meninges_morphology0.75750058
82MP0008789_abnormal_olfactory_epithelium0.75624242
83MP0000534_abnormal_ureter_morphology0.75084340
84MP0002132_abnormal_respiratory_system0.74050899
85MP0000163_abnormal_cartilage_morphology0.73999884
86MP0003252_abnormal_bile_duct0.72008580
87MP0000013_abnormal_adipose_tissue0.68859224
88MP0002269_muscular_atrophy0.65890637
89MP0005646_abnormal_pituitary_gland0.65625892
90MP0004145_abnormal_muscle_electrophysio0.65613412
91MP0005551_abnormal_eye_electrophysiolog0.63669469
92MP0001485_abnormal_pinna_reflex0.62281853
93MP0005083_abnormal_biliary_tract0.61529615
94MP0003936_abnormal_reproductive_system0.59113165
95MP0003935_abnormal_craniofacial_develop0.59068876
96MP0001664_abnormal_digestion0.56821077
97MP0005376_homeostasis/metabolism_phenot0.54931270
98MP0004957_abnormal_blastocyst_morpholog0.53912495
99MP0008058_abnormal_DNA_repair0.53761350
100MP0004087_abnormal_muscle_fiber0.53619170

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.11261880
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.97443438
3Absent/shortened dynein arms (HP:0200106)5.97443438
4Abnormal respiratory motile cilium physiology (HP:0012261)5.58841455
5Abnormal ciliary motility (HP:0012262)5.41284906
6Abnormal respiratory motile cilium morphology (HP:0005938)5.15869768
7Abnormal respiratory epithelium morphology (HP:0012253)5.15869768
8Severe visual impairment (HP:0001141)4.44997468
9Rhinitis (HP:0012384)4.36489325
10Chronic bronchitis (HP:0004469)3.96433440
11Thick nail (HP:0001805)3.53696330
12Male infertility (HP:0003251)3.49002036
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.08307241
14Abnormality of macular pigmentation (HP:0008002)3.08203024
15Chronic hepatic failure (HP:0100626)3.00900491
16Popliteal pterygium (HP:0009756)2.97988894
17Tubulointerstitial nephritis (HP:0001970)2.97124933
18Infertility (HP:0000789)2.96849219
19Abnormality of nail color (HP:0100643)2.96603758
20Nephronophthisis (HP:0000090)2.92469680
21Occipital encephalocele (HP:0002085)2.91445508
22Pancreatic fibrosis (HP:0100732)2.79831604
23Spastic paraparesis (HP:0002313)2.77728606
24Nasal polyposis (HP:0100582)2.73679991
25Abnormality of the renal medulla (HP:0100957)2.70673446
26Hyperkalemia (HP:0002153)2.70462153
27Bell-shaped thorax (HP:0001591)2.67753070
28Chromsome breakage (HP:0040012)2.64779261
29Bronchiectasis (HP:0002110)2.64028559
30Attenuation of retinal blood vessels (HP:0007843)2.62945226
31Resting tremor (HP:0002322)2.58980097
32True hermaphroditism (HP:0010459)2.54664277
33Cerebellar dysplasia (HP:0007033)2.53506301
34Median cleft lip (HP:0000161)2.44207358
35Milia (HP:0001056)2.42046523
36Short nail (HP:0001799)2.35553988
37Bony spicule pigmentary retinopathy (HP:0007737)2.35537223
38Congenital, generalized hypertrichosis (HP:0004540)2.34638389
39Reduced subcutaneous adipose tissue (HP:0003758)2.32887295
40Pancreatic cysts (HP:0001737)2.30557102
41Enlarged epiphyses (HP:0010580)2.25184430
42Type II lissencephaly (HP:0007260)2.23576935
43Muscle hypertrophy of the lower extremities (HP:0008968)2.21986274
44Abnormality of DNA repair (HP:0003254)2.20905402
45Hypophosphatemic rickets (HP:0004912)2.17805226
46Stage 5 chronic kidney disease (HP:0003774)2.16914773
47Reduced antithrombin III activity (HP:0001976)2.16804806
48Cone-rod dystrophy (HP:0000548)2.14144419
49Atrophic scars (HP:0001075)2.13237299
50Abnormality of the nasal mucosa (HP:0000433)2.11455001
51Onycholysis (HP:0001806)2.10768593
52Asymmetric septal hypertrophy (HP:0001670)2.10209084
53Calf muscle hypertrophy (HP:0008981)2.09723157
54Amniotic constriction ring (HP:0009775)2.09630909
55Abnormality of placental membranes (HP:0011409)2.09630909
56Hypoplastic ischia (HP:0003175)2.07945325
57Congenital hepatic fibrosis (HP:0002612)2.07035552
58Plantar hyperkeratosis (HP:0007556)2.04967503
59Paraparesis (HP:0002385)2.04773685
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.03858637
61Sclerocornea (HP:0000647)2.02811344
62Duplicated collecting system (HP:0000081)2.02573091
63Azoospermia (HP:0000027)2.02065113
64Abnormality of the calf musculature (HP:0001430)2.00710815
65Cystic liver disease (HP:0006706)1.98540604
66Abnormality of the preputium (HP:0100587)1.98183967
67Abnormality of the renal collecting system (HP:0004742)1.97948382
68Renal Fanconi syndrome (HP:0001994)1.96018265
69Aplasia/Hypoplasia of the tongue (HP:0010295)1.95501973
70Pili torti (HP:0003777)1.94439982
71Postaxial foot polydactyly (HP:0001830)1.94411830
72Right ventricular cardiomyopathy (HP:0011663)1.93196127
73Abnormal spermatogenesis (HP:0008669)1.90918261
74Renal dysplasia (HP:0000110)1.88529425
75Tubular atrophy (HP:0000092)1.85626812
76Aplasia cutis congenita (HP:0001057)1.83207261
77Male pseudohermaphroditism (HP:0000037)1.79718851
78Advanced eruption of teeth (HP:0006288)1.77784468
79Abnormality of midbrain morphology (HP:0002418)1.72810897
80Molar tooth sign on MRI (HP:0002419)1.72810897
81Alopecia of scalp (HP:0002293)1.71860981
82Insulin-resistant diabetes mellitus (HP:0000831)1.70919435
83Abnormality of the ischium (HP:0003174)1.70705865
84Tubulointerstitial abnormality (HP:0001969)1.70004130
85Elfin facies (HP:0004428)1.69960385
86Abnormality of the nasal septum (HP:0000419)1.69574700
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.69412477
88Hypoplasia of the uterus (HP:0000013)1.69322156
89Abnormality of dentin (HP:0010299)1.69241142
90Decreased central vision (HP:0007663)1.68873080
91Muscular dystrophy (HP:0003560)1.68066329
92Palmoplantar hyperkeratosis (HP:0000972)1.67732734
93Chronic sinusitis (HP:0011109)1.67663501
94Ureteral duplication (HP:0000073)1.66711063
95Abnormal rod and cone electroretinograms (HP:0008323)1.65770542
96Pendular nystagmus (HP:0012043)1.65550087
97Palmar hyperkeratosis (HP:0010765)1.65495167
98Entropion (HP:0000621)1.65215052
99Natal tooth (HP:0000695)1.62752060
100Furrowed tongue (HP:0000221)1.62234282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.66326873
2MST1R5.62963366
3STK38L3.50878291
4TESK13.31565979
5PLK43.30583264
6EPHA23.12854855
7MET2.72975709
8PINK12.66475814
9MAPK152.26741435
10MAP4K22.20050438
11DDR22.16400569
12STK382.01749439
13MAP3K91.99904606
14LATS11.77414882
15TSSK61.73528276
16ARAF1.58977942
17PRKD31.50829917
18BRD41.36673281
19IRAK21.33898895
20PBK1.28993983
21PNCK1.24629235
22LATS21.22433880
23NTRK11.20396608
24FER1.17217509
25MYLK1.16017294
26IRAK31.15169550
27OBSCN1.10464385
28EIF2AK31.10261935
29PLK21.06104671
30PTK2B1.04497774
31GRK11.03588783
32MARK31.03215839
33STK241.02878775
34NEK11.02334579
35MST41.02171513
36STK391.01653733
37EPHB20.99092724
38CSNK1A1L0.95051915
39BMPR1B0.93671806
40BRSK20.89067313
41ABL20.87163287
42IRAK10.86715319
43LIMK10.83088313
44PIM20.82382955
45NEK60.82160997
46BRAF0.80651354
47TRPM70.78716262
48TGFBR20.78251867
49ERBB40.77642580
50ROCK10.73262085
51ERBB30.69797366
52PRKCI0.68543687
53CSNK1G30.67570839
54PTK20.65394058
55PIK3CG0.65213129
56MAP3K20.64890765
57MAPKAPK50.63207645
58TGFBR10.56404772
59ZAK0.56330590
60RPS6KA40.55539078
61PRKG20.52555320
62MAPKAPK30.52181092
63MOS0.50614808
64STK30.49106358
65CSNK1G10.48693897
66RPS6KA50.48223604
67MAP2K70.46661796
68CDK30.46629237
69MAP2K10.44120390
70TNIK0.43391410
71YES10.43249490
72TLK10.43185834
73ROCK20.42378209
74MTOR0.40679476
75TTN0.40612597
76ADRBK10.38257144
77BMX0.38005219
78CDK70.37828943
79WNK30.37704447
80NME10.37599614
81MUSK0.37446497
82ADRBK20.37429750
83STK100.35309230
84GRK50.33424944
85PLK10.33388063
86WNK10.32014067
87BCKDK0.30230365
88PHKG20.28852410
89PHKG10.28852410
90AURKA0.27825927
91IGF1R0.27774622
92PDPK10.27363413
93CSNK1G20.27098117
94PAK30.26670586
95TESK20.25966674
96WNK40.25580555
97PRKAA20.25207340
98BRSK10.24799428
99CHEK10.24405233
100GRK70.24034844

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.46091472
2Fatty acid biosynthesis_Homo sapiens_hsa000612.72223540
3Olfactory transduction_Homo sapiens_hsa047402.69371763
4Selenocompound metabolism_Homo sapiens_hsa004502.63751298
5Butanoate metabolism_Homo sapiens_hsa006502.32998040
6Phenylalanine metabolism_Homo sapiens_hsa003602.30461446
7Circadian rhythm_Homo sapiens_hsa047102.23564249
8Fanconi anemia pathway_Homo sapiens_hsa034602.17394929
9Hedgehog signaling pathway_Homo sapiens_hsa043402.10800754
10Chemical carcinogenesis_Homo sapiens_hsa052041.92976489
11Steroid hormone biosynthesis_Homo sapiens_hsa001401.91420773
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88752857
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.82039319
14Basal transcription factors_Homo sapiens_hsa030221.81040180
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.76361710
16Homologous recombination_Homo sapiens_hsa034401.67219838
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.66062200
18ECM-receptor interaction_Homo sapiens_hsa045121.61099327
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59318847
20Tyrosine metabolism_Homo sapiens_hsa003501.56211088
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55068070
22ABC transporters_Homo sapiens_hsa020101.52426701
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44697128
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35574045
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33462034
26Adherens junction_Homo sapiens_hsa045201.21968130
27Arginine and proline metabolism_Homo sapiens_hsa003301.21845220
28Steroid biosynthesis_Homo sapiens_hsa001001.21174185
29Basal cell carcinoma_Homo sapiens_hsa052171.19458215
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19384488
31Arginine biosynthesis_Homo sapiens_hsa002201.16582386
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16081419
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16011302
34Tight junction_Homo sapiens_hsa045301.12617859
35Glycerolipid metabolism_Homo sapiens_hsa005611.10993940
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10427856
37Glutathione metabolism_Homo sapiens_hsa004801.10278475
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09591501
39Retinol metabolism_Homo sapiens_hsa008301.08973796
40Phototransduction_Homo sapiens_hsa047441.04867443
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04066368
42Histidine metabolism_Homo sapiens_hsa003401.03738420
43RNA transport_Homo sapiens_hsa030131.03495814
44Taste transduction_Homo sapiens_hsa047421.02414553
45beta-Alanine metabolism_Homo sapiens_hsa004101.02182806
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01362247
47Linoleic acid metabolism_Homo sapiens_hsa005910.98488438
48Propanoate metabolism_Homo sapiens_hsa006400.97559962
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.96906535
50Hippo signaling pathway_Homo sapiens_hsa043900.90543689
51Sphingolipid metabolism_Homo sapiens_hsa006000.89259397
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86002375
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78595685
54Focal adhesion_Homo sapiens_hsa045100.76232166
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74809559
56Fatty acid degradation_Homo sapiens_hsa000710.72812411
57Dilated cardiomyopathy_Homo sapiens_hsa054140.72003765
58Nucleotide excision repair_Homo sapiens_hsa034200.71310056
59Dorso-ventral axis formation_Homo sapiens_hsa043200.68514359
60Base excision repair_Homo sapiens_hsa034100.66104496
61Starch and sucrose metabolism_Homo sapiens_hsa005000.65934401
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65826993
63Glucagon signaling pathway_Homo sapiens_hsa049220.63608914
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.63076937
65Protein digestion and absorption_Homo sapiens_hsa049740.62900978
66TGF-beta signaling pathway_Homo sapiens_hsa043500.61629881
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.60256326
68Arachidonic acid metabolism_Homo sapiens_hsa005900.59998868
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59516008
70Purine metabolism_Homo sapiens_hsa002300.58131679
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56564450
72Mineral absorption_Homo sapiens_hsa049780.56431508
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55164167
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51628441
75Ovarian steroidogenesis_Homo sapiens_hsa049130.50393548
76Pyruvate metabolism_Homo sapiens_hsa006200.46905889
77Nitrogen metabolism_Homo sapiens_hsa009100.46564686
78Salivary secretion_Homo sapiens_hsa049700.46242806
79Thyroid cancer_Homo sapiens_hsa052160.45131296
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44887486
81Metabolic pathways_Homo sapiens_hsa011000.43332124
82PPAR signaling pathway_Homo sapiens_hsa033200.42867198
83Proteoglycans in cancer_Homo sapiens_hsa052050.42822388
84Apoptosis_Homo sapiens_hsa042100.40671180
85mRNA surveillance pathway_Homo sapiens_hsa030150.40429299
86Bile secretion_Homo sapiens_hsa049760.40338780
87Oocyte meiosis_Homo sapiens_hsa041140.39393810
88Calcium signaling pathway_Homo sapiens_hsa040200.38967643
89Pyrimidine metabolism_Homo sapiens_hsa002400.38732135
90Gap junction_Homo sapiens_hsa045400.38584445
91AMPK signaling pathway_Homo sapiens_hsa041520.38142229
92Choline metabolism in cancer_Homo sapiens_hsa052310.38087212
93Endocytosis_Homo sapiens_hsa041440.34670536
94Inositol phosphate metabolism_Homo sapiens_hsa005620.34225175
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33905282
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33462608
97Huntingtons disease_Homo sapiens_hsa050160.29979917
98Estrogen signaling pathway_Homo sapiens_hsa049150.28269240
99Insulin signaling pathway_Homo sapiens_hsa049100.28115579
100Axon guidance_Homo sapiens_hsa043600.28080610

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