CDRT15P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)6.99595448
2L-serine transport (GO:0015825)5.90058989
3binding of sperm to zona pellucida (GO:0007339)5.74771367
4tongue development (GO:0043586)5.19644451
5protein-DNA complex disassembly (GO:0032986)5.18485524
6nucleosome disassembly (GO:0006337)5.18485524
7serine transport (GO:0032329)5.14240485
8phospholipid scrambling (GO:0017121)4.97048224
9spermatid nucleus differentiation (GO:0007289)4.83524958
10sperm motility (GO:0030317)4.78897496
11fusion of sperm to egg plasma membrane (GO:0007342)4.73717412
12regulation of phosphoprotein phosphatase activity (GO:0043666)4.71477244
13positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.65203710
14sperm-egg recognition (GO:0035036)4.61775146
15spermatid development (GO:0007286)4.59994123
16multicellular organism reproduction (GO:0032504)4.59280640
17regulation of response to osmotic stress (GO:0047484)4.14021028
18cell-cell recognition (GO:0009988)4.07225322
19regulation of autophagic vacuole assembly (GO:2000785)4.04259146
20histone H3-K36 demethylation (GO:0070544)3.98142466
21regulation of oxidative stress-induced neuron death (GO:1903203)3.95322501
22male sex determination (GO:0030238)3.93775827
23reproduction (GO:0000003)3.89535399
24phosphatidylethanolamine biosynthetic process (GO:0006646)3.88354529
25chromosome condensation (GO:0030261)3.81629764
26cellular response to pH (GO:0071467)3.72307422
27TOR signaling (GO:0031929)3.69684532
28negative regulation of cell size (GO:0045792)3.47740105
29response to acidic pH (GO:0010447)3.47462192
30DNA packaging (GO:0006323)3.45456596
31positive regulation of catecholamine secretion (GO:0033605)3.45291655
32polyamine biosynthetic process (GO:0006596)3.40242559
33plasma membrane fusion (GO:0045026)3.40153882
34histone H3-K9 demethylation (GO:0033169)3.38170223
35peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.35652663
36phosphatidylethanolamine metabolic process (GO:0046337)3.35060475
37regulation of vacuole organization (GO:0044088)3.32951709
38cilium or flagellum-dependent cell motility (GO:0001539)3.30358065
39DNA topological change (GO:0006265)3.23628759
40regulation of histone H3-K27 methylation (GO:0061085)3.22710626
41negative thymic T cell selection (GO:0045060)3.21938379
42positive regulation of granulocyte differentiation (GO:0030854)3.16074842
43coronary vasculature morphogenesis (GO:0060977)3.14719069
44motile cilium assembly (GO:0044458)3.14569187
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.14539810
46axonemal dynein complex assembly (GO:0070286)3.14169025
47thymic T cell selection (GO:0045061)3.11748288
48single fertilization (GO:0007338)3.10734827
49coenzyme catabolic process (GO:0009109)3.10505958
50antigen processing and presentation of endogenous antigen (GO:0019883)3.08778862
51peptidyl-lysine dimethylation (GO:0018027)3.07089493
52negative T cell selection (GO:0043383)3.04594570
53positive regulation of gamma-delta T cell activation (GO:0046645)3.04118086
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.03021154
55positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.99066240
563-UTR-mediated mRNA stabilization (GO:0070935)2.96260676
57response to laminar fluid shear stress (GO:0034616)2.94002062
58detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.90651940
59mesenchymal-epithelial cell signaling (GO:0060638)2.87187076
60histone lysine demethylation (GO:0070076)2.86896434
61genitalia morphogenesis (GO:0035112)2.86696105
62male meiosis (GO:0007140)2.83924431
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80481669
64T cell selection (GO:0045058)2.79304806
65histone demethylation (GO:0016577)2.79015248
66regulation of ARF GTPase activity (GO:0032312)2.76135564
67germ cell development (GO:0007281)2.75024997
68N-terminal protein amino acid acetylation (GO:0006474)2.74330927
69regulation of granulocyte differentiation (GO:0030852)2.74283159
70sequestering of extracellular ligand from receptor (GO:0035581)2.72631956
71microtubule depolymerization (GO:0007019)2.72179778
72mannose metabolic process (GO:0006013)2.70079468
73DNA synthesis involved in DNA repair (GO:0000731)2.67818368
74regulation of NFAT protein import into nucleus (GO:0051532)2.65935850
75sexual reproduction (GO:0019953)2.64013044
76V(D)J recombination (GO:0033151)2.60745065
77negative regulation of erythrocyte differentiation (GO:0045647)2.60340502
78sperm capacitation (GO:0048240)2.59113057
79poly(A)+ mRNA export from nucleus (GO:0016973)2.54864924
80regulation of macroautophagy (GO:0016241)2.54795773
81glycolytic process (GO:0006096)2.53331796
82Leydig cell differentiation (GO:0033327)2.52291760
83cellular extravasation (GO:0045123)2.51071330
84negative regulation of phagocytosis (GO:0050765)2.50108180
85negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.49460645
86negative regulation of cell killing (GO:0031342)2.49460645
87cellular process involved in reproduction in multicellular organism (GO:0022412)2.49426966
88cellular response to epidermal growth factor stimulus (GO:0071364)2.46016283
89histone exchange (GO:0043486)2.41981216
90positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.41359816
91negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.41042846
92histone H4 deacetylation (GO:0070933)2.40142810
93negative regulation of viral entry into host cell (GO:0046597)2.39718484
94snRNA metabolic process (GO:0016073)2.39646289
95snRNA processing (GO:0016180)2.37700542
96glycogen metabolic process (GO:0005977)2.37577754
97ventricular system development (GO:0021591)2.36083542
98cardiac muscle cell differentiation (GO:0055007)2.35909443
99glucan metabolic process (GO:0044042)2.35287941
100cellular glucan metabolic process (GO:0006073)2.35287941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.23056640
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.40687649
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.35681336
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.24121781
5MYC_22102868_ChIP-Seq_BL_Human3.18521111
6VDR_21846776_ChIP-Seq_THP-1_Human2.70516791
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.68908932
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66327904
9E2F7_22180533_ChIP-Seq_HELA_Human2.59733410
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.43619964
11MAF_26560356_Chip-Seq_TH2_Human2.40106587
12RUNX_20019798_ChIP-Seq_JUKART_Human2.39339369
13UTX_26944678_Chip-Seq_JUKART_Human2.36023769
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.29724246
15KDM2B_26808549_Chip-Seq_DND41_Human2.25030059
16LXR_22292898_ChIP-Seq_THP-1_Human2.17623737
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.16381279
18MAF_26560356_Chip-Seq_TH1_Human2.10165998
19MYB_26560356_Chip-Seq_TH1_Human2.07138825
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03867804
21SPI1_23127762_ChIP-Seq_K562_Human1.97505067
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89419294
23MYB_26560356_Chip-Seq_TH2_Human1.86961883
24VDR_24763502_ChIP-Seq_THP-1_Human1.86000275
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82616879
26ELF1_20517297_ChIP-Seq_JURKAT_Human1.79454194
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78006689
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74998300
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68939077
30SPI1_23547873_ChIP-Seq_NB4_Human1.68300043
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63598434
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62666573
33TCF7_22412390_ChIP-Seq_EML_Mouse1.61778285
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58071760
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57788600
36AR_21909140_ChIP-Seq_LNCAP_Human1.56849774
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53552719
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.52447002
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51315974
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.48005990
41BCOR_27268052_Chip-Seq_Bcells_Human1.47922204
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47895227
43BCL6_27268052_Chip-Seq_Bcells_Human1.46243638
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.44106425
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40029378
46NCOR1_26117541_ChIP-Seq_K562_Human1.39135849
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36878404
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36573628
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.35397834
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34990934
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.34418567
52SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.32412435
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.30360068
54CIITA_25753668_ChIP-Seq_RAJI_Human1.30002313
55IGF1R_20145208_ChIP-Seq_DFB_Human1.27481657
56MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.26600276
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26538840
58CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26446655
59SMC4_20622854_ChIP-Seq_HELA_Human1.25593593
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25371843
61EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25267061
62SCL_19346495_ChIP-Seq_HPC-7_Human1.19560077
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18159770
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18100695
65RUNX1_27514584_Chip-Seq_MCF-7_Human1.17249660
66P68_20966046_ChIP-Seq_HELA_Human1.15361649
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15199304
68CTCF_21964334_Chip-Seq_Bcells_Human1.15188877
69RARA_24833708_ChIP-Seq_LIVER_Mouse1.13385641
70SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10910969
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09051398
72RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08538151
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.07713755
74NANOG_20526341_ChIP-Seq_ESCs_Human1.07635569
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05857118
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05484548
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.04754526
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04506204
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03569649
80SPI1_20517297_ChIP-Seq_HL60_Human1.03461814
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03408276
82P300_27268052_Chip-Seq_Bcells_Human1.03005015
83SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01489946
84STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97551561
85RAC3_21632823_ChIP-Seq_H3396_Human0.96824653
86UBF1/2_26484160_Chip-Seq_HMECs_Human0.96056457
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95230573
88RACK7_27058665_Chip-Seq_MCF-7_Human0.94935718
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94627978
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93907676
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93765104
92CTCF_27219007_Chip-Seq_Bcells_Human0.93540794
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93299150
94ETS1_21867929_ChIP-Seq_TH2_Mouse0.93189803
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.93099895
96CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92559880
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92398377
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91305021
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90570168
100RARB_24833708_ChIP-Seq_LIVER_Mouse0.89123909

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.96081968
2MP0008438_abnormal_cutaneous_collagen3.46706787
3MP0008004_abnormal_stomach_pH3.37855859
4MP0002132_abnormal_respiratory_system3.03497639
5MP0003763_abnormal_thymus_physiology2.83241964
6MP0008260_abnormal_autophagy2.61341402
7MP0002254_reproductive_system_inflammat2.60451413
8MP0003315_abnormal_perineum_morphology2.45729470
9MP0001929_abnormal_gametogenesis2.23126474
10MP0003698_abnormal_male_reproductive2.10544292
11MP0010094_abnormal_chromosome_stability2.04985562
12MP0003436_decreased_susceptibility_to2.01867367
13MP0000685_abnormal_immune_system1.96479512
14MP0003300_gastrointestinal_ulcer1.85375763
15MP0005499_abnormal_olfactory_system1.75659953
16MP0005394_taste/olfaction_phenotype1.75659953
17MP0003077_abnormal_cell_cycle1.74820222
18MP0005058_abnormal_lysosome_morphology1.71318096
19MP0005387_immune_system_phenotype1.69870950
20MP0001790_abnormal_immune_system1.69870950
21MP0001849_ear_inflammation1.69744210
22MP0001348_abnormal_lacrimal_gland1.67879582
23MP0003566_abnormal_cell_adhesion1.63085356
24MP0001835_abnormal_antigen_presentation1.60742308
25MP0002396_abnormal_hematopoietic_system1.54037059
26MP0000703_abnormal_thymus_morphology1.53406429
27MP0002127_abnormal_cardiovascular_syste1.51653389
28MP0003091_abnormal_cell_migration1.49676675
29MP0002398_abnormal_bone_marrow1.47958286
30MP0003693_abnormal_embryo_hatching1.47378991
31MP0001661_extended_life_span1.43952742
32MP0008057_abnormal_DNA_replication1.43161118
33MP0005503_abnormal_tendon_morphology1.40370920
34MP0003111_abnormal_nucleus_morphology1.34863680
35MP0005275_abnormal_skin_tensile1.31775791
36MP0001730_embryonic_growth_arrest1.30154905
37MP0002249_abnormal_larynx_morphology1.26686205
38MP0002108_abnormal_muscle_morphology1.25799798
39MP0002420_abnormal_adaptive_immunity1.25245339
40MP0005310_abnormal_salivary_gland1.24346678
41MP0001800_abnormal_humoral_immune1.24265755
42MP0008007_abnormal_cellular_replicative1.22543417
43MP0001819_abnormal_immune_cell1.22509778
44MP0005671_abnormal_response_to1.18982525
45MP0002722_abnormal_immune_system1.18851954
46MP0008058_abnormal_DNA_repair1.16142262
47MP0002405_respiratory_system_inflammati1.14954879
48MP0002161_abnormal_fertility/fecundity1.14358450
49MP0010155_abnormal_intestine_physiology1.12059709
50MP0001873_stomach_inflammation1.11534865
51MP0002419_abnormal_innate_immunity1.09460115
52MP0000767_abnormal_smooth_muscle1.09132426
53MP0005451_abnormal_body_composition1.07948738
54MP0006035_abnormal_mitochondrial_morpho1.07489850
55MP0005000_abnormal_immune_tolerance1.06803667
56MP0001853_heart_inflammation1.06632285
57MP0000716_abnormal_immune_system1.06348106
58MP0005025_abnormal_response_to1.04941341
59MP0002723_abnormal_immune_serum1.04587954
60MP0001145_abnormal_male_reproductive1.04055159
61MP0009115_abnormal_fat_cell1.02727325
62MP0002452_abnormal_antigen_presenting1.02130110
63MP0004808_abnormal_hematopoietic_stem1.01350826
64MP0002429_abnormal_blood_cell1.00544312
65MP0002210_abnormal_sex_determination1.00125953
66MP0010307_abnormal_tumor_latency0.99614711
67MP0004084_abnormal_cardiac_muscle0.99378928
68MP0000689_abnormal_spleen_morphology0.96039656
69MP0000678_abnormal_parathyroid_gland0.94963071
70MP0002166_altered_tumor_susceptibility0.91878256
71MP0000538_abnormal_urinary_bladder0.90401601
72MP0008995_early_reproductive_senescence0.89363676
73MP0004233_abnormal_muscle_weight0.88388937
74MP0000313_abnormal_cell_death0.86535564
75MP0000350_abnormal_cell_proliferation0.85791296
76MP0005621_abnormal_cell_physiology0.84955906
77MP0003279_aneurysm0.84227062
78MP0000749_muscle_degeneration0.83693504
79MP0002009_preneoplasia0.83054529
80MP0003448_altered_tumor_morphology0.82790977
81MP0003221_abnormal_cardiomyocyte_apopto0.82260165
82MP0004036_abnormal_muscle_relaxation0.80174019
83MP0000653_abnormal_sex_gland0.79434700
84MP0005076_abnormal_cell_differentiation0.79105441
85MP0009278_abnormal_bone_marrow0.78746786
86MP0006036_abnormal_mitochondrial_physio0.78632782
87MP0000358_abnormal_cell_content/0.78013894
88MP0002970_abnormal_white_adipose0.77794842
89MP0000733_abnormal_muscle_development0.76464527
90MP0009333_abnormal_splenocyte_physiolog0.75175063
91MP0003705_abnormal_hypodermis_morpholog0.74903966
92MP0009697_abnormal_copulation0.74668357
93MP0000534_abnormal_ureter_morphology0.73004339
94MP0001845_abnormal_inflammatory_respons0.69935014
95MP0000490_abnormal_crypts_of0.69217542
96MP0003045_fibrosis0.69139589
97MP0001672_abnormal_embryogenesis/_devel0.68592769
98MP0005380_embryogenesis_phenotype0.68592769
99MP0000537_abnormal_urethra_morphology0.64433076
100MP0003984_embryonic_growth_retardation0.64145112

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal infarctions (HP:0005244)5.69840101
2Peritonitis (HP:0002586)4.49302052
3Prolonged partial thromboplastin time (HP:0003645)3.65641435
4Colitis (HP:0002583)3.59867492
5Resting tremor (HP:0002322)3.26369905
6Granulocytopenia (HP:0001913)3.20156894
7Abnormal sex determination (HP:0012244)3.16127987
8Sex reversal (HP:0012245)3.16127987
9Spinal cord lesions (HP:0100561)3.11556912
10Syringomyelia (HP:0003396)3.11556912
11Annular pancreas (HP:0001734)3.09569610
12Eosinophilia (HP:0001880)3.06280692
13Abnormality of the columella (HP:0009929)3.05727237
14Eczematoid dermatitis (HP:0000976)3.03956903
15Gonadal dysgenesis (HP:0000133)2.93700890
16Deep venous thrombosis (HP:0002625)2.93365560
17Periodontitis (HP:0000704)2.90139723
18Gastrointestinal inflammation (HP:0004386)2.86910047
19Inflammation of the large intestine (HP:0002037)2.86313712
20Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.84164261
21Hypoalphalipoproteinemia (HP:0003233)2.75808173
22Nasal polyposis (HP:0100582)2.71607930
23Facial hemangioma (HP:0000329)2.59199097
24Malignant hyperthermia (HP:0002047)2.51243537
25Increased IgE level (HP:0003212)2.44487269
26Termporal pattern (HP:0011008)2.43610727
27Insidious onset (HP:0003587)2.43610727
28Asymmetry of the thorax (HP:0001555)2.43191261
29Germ cell neoplasia (HP:0100728)2.42057707
30Prolonged bleeding time (HP:0003010)2.40649446
31Abnormality of the intrinsic pathway (HP:0010989)2.39683908
32Abnormality of the peritoneum (HP:0002585)2.38810021
33Papilledema (HP:0001085)2.34795787
34Upper motor neuron abnormality (HP:0002127)2.33111390
35Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32816531
36Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.29760801
37Abnormal gallbladder physiology (HP:0012438)2.29620304
38Cholecystitis (HP:0001082)2.29620304
39Infertility (HP:0000789)2.29482832
40Short humerus (HP:0005792)2.29191631
41Hypoplasia of the uterus (HP:0000013)2.24467161
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.24343603
43Premature loss of primary teeth (HP:0006323)2.23651032
44Autoimmune hemolytic anemia (HP:0001890)2.22655578
45Gingivitis (HP:0000230)2.22215520
46Aplasia/hypoplasia of the humerus (HP:0006507)2.18105302
47Abnormality of the nasal mucosa (HP:0000433)2.17746248
48Basal cell carcinoma (HP:0002671)2.17496304
49Increased IgM level (HP:0003496)2.16517132
50Reduced antithrombin III activity (HP:0001976)2.16399116
51Acute hepatic failure (HP:0006554)2.16156343
52Abnormality of eosinophils (HP:0001879)2.15440387
53High anterior hairline (HP:0009890)2.13343031
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.11996124
55Premature skin wrinkling (HP:0100678)2.11547832
56Spinal rigidity (HP:0003306)2.09094844
57Rhabdomyosarcoma (HP:0002859)2.07571292
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.07354435
59Cellulitis (HP:0100658)2.06065831
60Menstrual irregularities (HP:0000858)2.05432249
61Thoracic kyphosis (HP:0002942)2.05272160
62Ependymoma (HP:0002888)2.02937856
63Premature rupture of membranes (HP:0001788)2.01542289
64Neoplasm of striated muscle (HP:0009728)2.01006419
65Abnormal pancreas size (HP:0012094)2.00008601
66Pustule (HP:0200039)1.99756639
67Thoracolumbar scoliosis (HP:0002944)1.98848121
68Joint hemorrhage (HP:0005261)1.95717882
69Abnormality of the frontal sinuses (HP:0002687)1.94223432
70Abnormality of cells of the lymphoid lineage (HP:0012140)1.93291548
71Atrophic scars (HP:0001075)1.84069235
72Proximal placement of thumb (HP:0009623)1.83731877
73Easy fatigability (HP:0003388)1.82259835
74Leukocytosis (HP:0001974)1.81976715
75Blue sclerae (HP:0000592)1.81918795
76Abnormal hair whorl (HP:0010721)1.79968141
77Spontaneous hematomas (HP:0007420)1.79813247
78Panhypogammaglobulinemia (HP:0003139)1.79382431
79Ankyloglossia (HP:0010296)1.79187429
80Deviation of the thumb (HP:0009603)1.78165190
81Recurrent fungal infections (HP:0002841)1.77726853
82Biconcave vertebral bodies (HP:0004586)1.76353197
83Intestinal fistula (HP:0100819)1.76343185
84Lymphopenia (HP:0001888)1.76183808
85Abnormality of lateral ventricle (HP:0030047)1.75751521
86Self-mutilation (HP:0000742)1.74979289
87Abnormality of DNA repair (HP:0003254)1.73891196
88Asymmetric septal hypertrophy (HP:0001670)1.73814242
89Abnormality of primary teeth (HP:0006481)1.72774838
90Cerebral aneurysm (HP:0004944)1.71363625
91Long eyelashes (HP:0000527)1.71346455
92Vaginal fistula (HP:0004320)1.71167851
93Bony spicule pigmentary retinopathy (HP:0007737)1.67338606
94Recurrent viral infections (HP:0004429)1.67236428
95Dyschromatopsia (HP:0007641)1.66783962
96Hypoplasia of the thymus (HP:0000778)1.66053531
97Sensory axonal neuropathy (HP:0003390)1.65548686
98Menorrhagia (HP:0000132)1.64693044
99Postural instability (HP:0002172)1.64365062
100Hyporeflexia of lower limbs (HP:0002600)1.63799470

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.33039752
2PINK14.23652104
3MARK33.75931374
4MAP3K103.04492640
5IRAK32.86304173
6PKN22.85499480
7GRK62.84188326
8PRKD32.49180222
9MAP4K12.27967283
10ERN12.13064398
11TRIB32.05316277
12EEF2K2.03068299
13SIK32.01714355
14LATS21.95603319
15STK381.91835969
16EPHB11.81151002
17PRPF4B1.80937210
18NLK1.76190464
19MAP3K131.68361989
20NEK21.57577997
21PTK2B1.44531362
22BLK1.43929399
23SIK21.40232515
24RIPK41.33263347
25KSR21.32418725
26FGFR41.28024878
27MAP3K31.24438443
28STK101.19318975
29CDK121.16620763
30MAP3K11.16468245
31MARK21.16189801
32TNK21.14897671
33EPHA31.11546383
34BTK1.10479289
35GRK11.09421761
36SIK11.09232576
37TYK21.03460545
38CDK41.03319089
39MAP3K81.00848048
40SMG10.96599385
41HCK0.84653582
42MAPK110.83379765
43ZAP700.79902716
44ACVR1B0.77136689
45CDC42BPA0.75686684
46TLK10.74197676
47FLT30.74040490
48ICK0.73539544
49SRPK10.73105309
50RET0.69697963
51CDK60.68325120
52PASK0.66513330
53PRKD20.66164887
54MAP2K30.65685455
55FGFR30.65000761
56TGFBR10.63727627
57MAP3K70.62240011
58CAMK1D0.61496125
59NME20.60651422
60RPS6KA50.60637086
61IRAK40.60479156
62BRAF0.58627390
63DDR20.58565160
64MTOR0.58413300
65PAK10.57802409
66GRK50.55827526
67IRAK10.55538532
68DYRK30.54481124
69NME10.52883237
70MAPK120.49896904
71CAMK1G0.49835087
72JAK10.49067243
73MAPKAPK20.49060391
74LATS10.47198548
75BUB10.46061552
76ADRBK20.45639594
77STK40.45311862
78IRAK20.44249451
79ITK0.41274453
80JAK30.40401963
81PAK40.39962686
82JAK20.39016142
83FES0.38683591
84PDK10.37504272
85PBK0.37448797
86RAF10.35425509
87BMPR1B0.35336928
88MELK0.35069693
89PRKCQ0.34539862
90MYLK0.34144784
91MOS0.33611834
92BRD40.32824939
93SYK0.31480743
94TTK0.30416095
95HIPK20.30415539
96FGR0.30281807
97CHEK10.29709247
98PTK60.29576692
99CSK0.26774640
100PDPK10.26357415

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.44151304
2Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.49229250
3Acute myeloid leukemia_Homo sapiens_hsa052212.15108852
4B cell receptor signaling pathway_Homo sapiens_hsa046622.03171918
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.99600753
6Non-small cell lung cancer_Homo sapiens_hsa052231.97470277
7Apoptosis_Homo sapiens_hsa042101.86096060
8mRNA surveillance pathway_Homo sapiens_hsa030151.75485822
9Dorso-ventral axis formation_Homo sapiens_hsa043201.70078587
10Gap junction_Homo sapiens_hsa045401.59432135
11Prostate cancer_Homo sapiens_hsa052151.59190979
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57694710
13Central carbon metabolism in cancer_Homo sapiens_hsa052301.51618905
14Olfactory transduction_Homo sapiens_hsa047401.48920802
15T cell receptor signaling pathway_Homo sapiens_hsa046601.48878218
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.46464266
17Hedgehog signaling pathway_Homo sapiens_hsa043401.45633769
18mTOR signaling pathway_Homo sapiens_hsa041501.43687895
19Measles_Homo sapiens_hsa051621.37174094
20Primary immunodeficiency_Homo sapiens_hsa053401.36361726
21Herpes simplex infection_Homo sapiens_hsa051681.35505379
22Hepatitis B_Homo sapiens_hsa051611.29384321
23Other glycan degradation_Homo sapiens_hsa005111.28446884
24Cell cycle_Homo sapiens_hsa041101.25110910
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23245728
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22579188
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19764368
28Osteoclast differentiation_Homo sapiens_hsa043801.17512720
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13821728
30One carbon pool by folate_Homo sapiens_hsa006701.13204101
31HIF-1 signaling pathway_Homo sapiens_hsa040661.11628172
32Malaria_Homo sapiens_hsa051441.10693913
33Choline metabolism in cancer_Homo sapiens_hsa052311.10579106
34Legionellosis_Homo sapiens_hsa051341.08940178
35Phagosome_Homo sapiens_hsa041451.06716898
36Chronic myeloid leukemia_Homo sapiens_hsa052201.06332921
37Leishmaniasis_Homo sapiens_hsa051401.05308450
38RNA transport_Homo sapiens_hsa030131.03793591
39Thyroid cancer_Homo sapiens_hsa052161.03578335
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.02242458
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01817614
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01377066
43Pancreatic cancer_Homo sapiens_hsa052121.01265739
44Biosynthesis of amino acids_Homo sapiens_hsa012300.99599787
45DNA replication_Homo sapiens_hsa030300.96495545
46Viral carcinogenesis_Homo sapiens_hsa052030.96167294
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95121041
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.94467328
49Influenza A_Homo sapiens_hsa051640.92839924
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92351857
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87759772
52Small cell lung cancer_Homo sapiens_hsa052220.86824727
53Endometrial cancer_Homo sapiens_hsa052130.86233853
54Base excision repair_Homo sapiens_hsa034100.83408315
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82027849
56Toxoplasmosis_Homo sapiens_hsa051450.81462884
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81423698
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80318065
59FoxO signaling pathway_Homo sapiens_hsa040680.79987045
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78855656
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78356027
62Glioma_Homo sapiens_hsa052140.77864288
63Spliceosome_Homo sapiens_hsa030400.77837009
64Inositol phosphate metabolism_Homo sapiens_hsa005620.77298688
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75824557
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.72658414
67VEGF signaling pathway_Homo sapiens_hsa043700.71787661
68AMPK signaling pathway_Homo sapiens_hsa041520.71040018
69HTLV-I infection_Homo sapiens_hsa051660.70822755
70Complement and coagulation cascades_Homo sapiens_hsa046100.70799881
71Insulin resistance_Homo sapiens_hsa049310.70724894
72Insulin signaling pathway_Homo sapiens_hsa049100.69283440
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68817702
74Melanoma_Homo sapiens_hsa052180.68676213
75Colorectal cancer_Homo sapiens_hsa052100.66729520
76Butanoate metabolism_Homo sapiens_hsa006500.66522226
77Oocyte meiosis_Homo sapiens_hsa041140.66088045
78Endocytosis_Homo sapiens_hsa041440.65759678
79Non-homologous end-joining_Homo sapiens_hsa034500.65073915
80Carbon metabolism_Homo sapiens_hsa012000.63750325
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62941922
82Sulfur relay system_Homo sapiens_hsa041220.62901505
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.61491493
84Renal cell carcinoma_Homo sapiens_hsa052110.59976506
85Graft-versus-host disease_Homo sapiens_hsa053320.59278392
86Shigellosis_Homo sapiens_hsa051310.58224314
87Allograft rejection_Homo sapiens_hsa053300.57412178
88Autoimmune thyroid disease_Homo sapiens_hsa053200.57052319
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56398003
90MicroRNAs in cancer_Homo sapiens_hsa052060.55912371
91Platelet activation_Homo sapiens_hsa046110.54828118
92Hematopoietic cell lineage_Homo sapiens_hsa046400.54630191
93Tuberculosis_Homo sapiens_hsa051520.54307564
94Epstein-Barr virus infection_Homo sapiens_hsa051690.53626209
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53330277
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52476064
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52272225
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51562095
99Pentose phosphate pathway_Homo sapiens_hsa000300.50964430
100Proteoglycans in cancer_Homo sapiens_hsa052050.50259575

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