CDRT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.91234240
2epithelial cilium movement (GO:0003351)9.86024523
3axonemal dynein complex assembly (GO:0070286)9.54435711
4motile cilium assembly (GO:0044458)9.49015545
5reproduction (GO:0000003)9.48004320
6regulation of cilium movement (GO:0003352)8.58703114
7cilium or flagellum-dependent cell motility (GO:0001539)8.42599183
8cilium movement (GO:0003341)7.86924463
9negative regulation of inclusion body assembly (GO:0090084)7.46734100
10sperm capacitation (GO:0048240)7.35646394
11single fertilization (GO:0007338)7.35089081
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.20110675
13synaptonemal complex organization (GO:0070193)6.86884837
14organic cation transport (GO:0015695)6.83651093
15spermatogenesis (GO:0007283)6.83640402
16male gamete generation (GO:0048232)6.81145304
17microtubule depolymerization (GO:0007019)6.78935090
18synaptonemal complex assembly (GO:0007130)6.76753022
19male meiosis (GO:0007140)6.58544455
20response to pheromone (GO:0019236)6.46080007
21piRNA metabolic process (GO:0034587)6.42768475
22gamete generation (GO:0007276)6.26026311
23regulation of inclusion body assembly (GO:0090083)6.22565340
24fertilization (GO:0009566)6.21328533
25calcium ion-dependent exocytosis (GO:0017156)5.76301377
26spermatid nucleus differentiation (GO:0007289)5.63367367
27chromosome condensation (GO:0030261)5.59211980
28germ cell development (GO:0007281)5.46119179
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.36976584
30glycerol ether metabolic process (GO:0006662)5.29416989
31DNA packaging (GO:0006323)5.27181618
32regulation of microtubule-based movement (GO:0060632)5.09797009
33cell recognition (GO:0008037)5.07283454
34ventricular system development (GO:0021591)5.00749334
35phenol-containing compound catabolic process (GO:0019336)4.97944109
36multicellular organismal reproductive process (GO:0048609)4.93520013
37ether metabolic process (GO:0018904)4.89353853
38centriole replication (GO:0007099)4.88241449
39sexual reproduction (GO:0019953)4.87202576
40microtubule severing (GO:0051013)4.64571665
41chromosome organization involved in meiosis (GO:0070192)4.53864190
42single strand break repair (GO:0000012)4.51654470
43seminiferous tubule development (GO:0072520)4.51202624
44male meiosis I (GO:0007141)4.48008164
45phosphatidylethanolamine biosynthetic process (GO:0006646)4.41223198
46chaperone-mediated protein complex assembly (GO:0051131)4.30610029
47central nervous system myelination (GO:0022010)4.27296055
48axon ensheathment in central nervous system (GO:0032291)4.27296055
49left/right pattern formation (GO:0060972)4.25397573
50centriole assembly (GO:0098534)4.23168571
51DNA methylation involved in gamete generation (GO:0043046)4.13092328
52phosphatidylethanolamine metabolic process (GO:0046337)4.07160694
53meiotic nuclear division (GO:0007126)3.98723466
54multicellular organismal development (GO:0007275)3.97488296
55nephron epithelium morphogenesis (GO:0072088)3.82622175
56nephron tubule morphogenesis (GO:0072078)3.82622175
57establishment of protein localization to Golgi (GO:0072600)3.66948333
58microtubule bundle formation (GO:0001578)3.63963353
59protein targeting to Golgi (GO:0000042)3.61428149
60urinary tract smooth muscle contraction (GO:0014848)3.58986037
61meiosis I (GO:0007127)3.57756546
62sequestering of actin monomers (GO:0042989)3.56574177
63protein K11-linked deubiquitination (GO:0035871)3.56008467
64microtubule polymerization or depolymerization (GO:0031109)3.50614799
65nonmotile primary cilium assembly (GO:0035058)3.45772120
66genitalia morphogenesis (GO:0035112)3.43858341
67retrograde transport, vesicle recycling within Golgi (GO:0000301)3.38704082
68protein refolding (GO:0042026)3.37514654
69protein polyglutamylation (GO:0018095)3.37142732
70regulation of spindle checkpoint (GO:0090231)3.33978521
71glycolytic process (GO:0006096)3.27825756
72nucleus organization (GO:0006997)3.19675910
73positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.15948495
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.14864521
75meiotic cell cycle (GO:0051321)3.12942671
76monoubiquitinated protein deubiquitination (GO:0035520)3.10732293
77amino-acid betaine transport (GO:0015838)3.09629147
78carnitine transport (GO:0015879)3.09629147
79positive regulation of macrophage activation (GO:0043032)3.07903892
80positive regulation of gastrulation (GO:2000543)3.06997924
81chemosensory behavior (GO:0007635)3.06646401
82polyol catabolic process (GO:0046174)3.05539237
83negative regulation of astrocyte differentiation (GO:0048712)3.04348452
84negative regulation of oligodendrocyte differentiation (GO:0048715)3.03435946
85mitotic sister chromatid cohesion (GO:0007064)3.01641243
86polyamine biosynthetic process (GO:0006596)3.00889020
87left/right axis specification (GO:0070986)2.99619322
88protein localization to Golgi apparatus (GO:0034067)2.98881252
89nucleoside diphosphate phosphorylation (GO:0006165)2.98550905
90cellular ketone body metabolic process (GO:0046950)2.98475156
91alditol metabolic process (GO:0019400)2.96283398
92interferon-gamma secretion (GO:0072643)2.94625991
93somite rostral/caudal axis specification (GO:0032525)2.93624251
94DNA deamination (GO:0045006)2.93613159
95adaptation of signaling pathway (GO:0023058)2.93272445
96protein localization to cilium (GO:0061512)2.92768967
97carnitine transmembrane transport (GO:1902603)2.89294722
98behavioral response to nicotine (GO:0035095)2.85977260
99RNA localization (GO:0006403)2.85140747
100chromatin silencing (GO:0006342)2.84071919
101cerebral cortex neuron differentiation (GO:0021895)2.83639741
102cell differentiation involved in metanephros development (GO:0072202)2.80147988
103phosphatidylcholine biosynthetic process (GO:0006656)2.79542338
104rRNA methylation (GO:0031167)2.78717589
105RNA destabilization (GO:0050779)2.76240857
106regulation of cilium assembly (GO:1902017)2.74434988
107GTP biosynthetic process (GO:0006183)2.72799729
108cilium organization (GO:0044782)2.69679141
109gamma-aminobutyric acid transport (GO:0015812)2.67581551
110peristalsis (GO:0030432)2.67150264
111sleep (GO:0030431)2.65893641
112microtubule-based movement (GO:0007018)2.64566091
113regulation of collateral sprouting (GO:0048670)2.64137505
114meiotic cell cycle process (GO:1903046)2.62901031
115cilium assembly (GO:0042384)2.60161419
116cellular component assembly involved in morphogenesis (GO:0010927)2.59740707
117cilium morphogenesis (GO:0060271)2.59636810
118ketone body metabolic process (GO:1902224)2.59617971
119negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.58179944
120mitochondrion degradation (GO:0000422)2.58174503
121auditory behavior (GO:0031223)2.57972535
122lateral ventricle development (GO:0021670)2.55861193
123synapsis (GO:0007129)2.55025666
124renal tubule morphogenesis (GO:0061333)2.54238704
125pattern specification involved in kidney development (GO:0061004)2.50896324
126negative regulation of Rho protein signal transduction (GO:0035024)2.50506023
127neuronal action potential (GO:0019228)2.48899014
128sensory perception of smell (GO:0007608)2.48119716
129lateral sprouting from an epithelium (GO:0060601)2.48029730
130glycerol metabolic process (GO:0006071)2.46544855
131regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.46465583
132positive regulation of glycolytic process (GO:0045821)2.45976547
133axoneme assembly (GO:0035082)2.45960160
134cranial nerve morphogenesis (GO:0021602)2.45339916
135detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.44415654
136UTP biosynthetic process (GO:0006228)2.44278338
137dendritic spine morphogenesis (GO:0060997)2.44034909
138positive regulation of Rab GTPase activity (GO:0032851)2.44010845
139regulation of Rab GTPase activity (GO:0032313)2.44010845
140intraciliary transport (GO:0042073)2.42929636
141lactate metabolic process (GO:0006089)2.42524949
142spinal cord motor neuron differentiation (GO:0021522)2.41843050
143peptidyl-glutamic acid modification (GO:0018200)2.40642969
144sperm motility (GO:0030317)14.3980120
145cell wall macromolecule metabolic process (GO:0044036)13.9189566
146cell wall macromolecule catabolic process (GO:0016998)13.9189566
147fusion of sperm to egg plasma membrane (GO:0007342)13.3920617
148acrosome reaction (GO:0007340)12.4726020
149sperm-egg recognition (GO:0035036)11.6630018
150acrosome assembly (GO:0001675)11.5427838
151multicellular organism reproduction (GO:0032504)10.7966196
152binding of sperm to zona pellucida (GO:0007339)10.6012900
153cell-cell recognition (GO:0009988)10.4395900
154plasma membrane fusion (GO:0045026)10.2030299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.15790580
2EZH2_22144423_ChIP-Seq_EOC_Human4.06735174
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.75704816
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.27024145
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.91786592
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.90381967
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.82703549
8VDR_22108803_ChIP-Seq_LS180_Human2.60209329
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.41101670
10* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.25457395
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.22024169
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17715608
13FUS_26573619_Chip-Seq_HEK293_Human2.15303910
14EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05956264
15AR_21572438_ChIP-Seq_LNCaP_Human2.04988572
16ZNF274_21170338_ChIP-Seq_K562_Hela2.04442020
17DROSHA_22980978_ChIP-Seq_HELA_Human2.00992583
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97808214
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.94023900
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91370163
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88883062
22P300_19829295_ChIP-Seq_ESCs_Human1.84262915
23KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.84248269
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78250830
25MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.77842141
26FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76048387
27STAT1_17558387_ChIP-Seq_HELA_Human1.74574681
28* SMAD3_21741376_ChIP-Seq_EPCs_Human1.73000425
29GBX2_23144817_ChIP-Seq_PC3_Human1.72667373
30SOX2_22085726_ChIP-Seq_NPCs_Mouse1.71341031
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68903223
32TOP2B_26459242_ChIP-Seq_MCF-7_Human1.66726896
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.66513788
34* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.66401048
35GATA3_21867929_ChIP-Seq_CD8_Mouse1.60409777
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59847046
37ER_23166858_ChIP-Seq_MCF-7_Human1.56587608
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.56163870
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51034998
40* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.51011463
41KDM2B_26808549_Chip-Seq_REH_Human1.50615621
42* AR_25329375_ChIP-Seq_VCAP_Human1.47207376
43FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.45636662
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45606443
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45468183
46RNF2_27304074_Chip-Seq_NSC_Mouse1.45349811
47* PIAS1_25552417_ChIP-Seq_VCAP_Human1.45202405
48TAL1_26923725_Chip-Seq_HPCs_Mouse1.44675396
49PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.43490527
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.43218329
51BCAT_22108803_ChIP-Seq_LS180_Human1.42975427
52KAP1_22055183_ChIP-Seq_ESCs_Mouse1.42093580
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41764043
54* SMAD4_21741376_ChIP-Seq_EPCs_Human1.41577048
55CBP_20019798_ChIP-Seq_JUKART_Human1.40037485
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40037485
57P53_21459846_ChIP-Seq_SAOS-2_Human1.38298997
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.38116707
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37584581
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.37502804
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37430785
62RUNX2_22187159_ChIP-Seq_PCA_Human1.37003317
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.36947404
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.36588322
65SMAD4_21799915_ChIP-Seq_A2780_Human1.35887344
66REST_21632747_ChIP-Seq_MESCs_Mouse1.34705607
67STAT3_23295773_ChIP-Seq_U87_Human1.34219832
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33622226
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32978263
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32505382
71SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32475065
72* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32049041
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30946727
74MYC_19829295_ChIP-Seq_ESCs_Human1.30121288
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30032519
76GATA3_21867929_ChIP-Seq_TH1_Mouse1.29558204
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26980690
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26284235
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25720450
80TCF4_22108803_ChIP-Seq_LS180_Human1.25697268
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25618885
82GF1_26923725_Chip-Seq_HPCs_Mouse1.24669326
83RAD21_21589869_ChIP-Seq_MESCs_Mouse1.24662748
84NANOG_19829295_ChIP-Seq_ESCs_Human1.24612591
85SOX2_19829295_ChIP-Seq_ESCs_Human1.24612591
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24162288
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22071042
88CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21036675
89CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20396649
90* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20319342
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20265055
92TCF4_23295773_ChIP-Seq_U87_Human1.20181710
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19305483
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.18954539
95* SMAD3_21741376_ChIP-Seq_ESCs_Human1.18771432
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18632551
97MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18607142
98SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18593658
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18368606
100FOXA1_25329375_ChIP-Seq_VCAP_Human1.18368606
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.17117197
102* FLI1_21867929_ChIP-Seq_TH2_Mouse1.16983577
103IGF1R_20145208_ChIP-Seq_DFB_Human1.16421705
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15479168
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.15007540
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14654502
107TBL1_22424771_ChIP-Seq_293T_Human1.14338335
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12810135
109RNF2_27304074_Chip-Seq_ESCs_Mouse1.12519285
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12325099
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12325099
112SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12134652
113SMAD4_21741376_ChIP-Seq_HESCs_Human1.12097776
114RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11043839
115EWS_26573619_Chip-Seq_HEK293_Human1.10980095
116ERA_21632823_ChIP-Seq_H3396_Human1.09756864
117* SPI1_26923725_Chip-Seq_HPCs_Mouse1.09580781
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09425110
119EED_16625203_ChIP-ChIP_MESCs_Mouse1.09422438
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08839085
121ETV1_20927104_ChIP-Seq_GIST48_Human1.08659960
122RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08525174
123ERG_20517297_ChIP-Seq_VCAP_Human1.08333447
124SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07732279
125TAF15_26573619_Chip-Seq_HEK293_Human1.06889958
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06786407
127GATA3_21878914_ChIP-Seq_MCF-7_Human1.06621737
128TET1_21451524_ChIP-Seq_MESCs_Mouse1.06620649
129JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.06603635
130ESET_19884257_ChIP-Seq_ESCs_Mouse1.05974986
131* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05768933
132YY1_22570637_ChIP-Seq_MALME-3M_Human1.05657758
133RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05650152
134AHR_22903824_ChIP-Seq_MCF-7_Human1.05467649
135EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04779961
136* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04687724
137NCOR_22424771_ChIP-Seq_293T_Human1.03686811
138RARA_24833708_ChIP-Seq_LIVER_Mouse1.03663609
139PHF8_20622853_ChIP-Seq_HELA_Human1.03322363
140SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03040994
141SMRT_27268052_Chip-Seq_Bcells_Human1.02901114
142* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.02540344
143* MYC_27129775_Chip-Seq_CORNEA_Mouse1.02533765
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02205750
145P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01774477
146RING1B_27294783_Chip-Seq_ESCs_Mouse1.01602500
147NANOG_18555785_Chip-Seq_ESCs_Mouse1.01118615
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00908559
149CTCF_27219007_Chip-Seq_Bcells_Human1.00604274
150FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99822761
151* CRX_20693478_ChIP-Seq_RETINA_Mouse0.99640340
152SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99167907
153* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98746972
154TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97637134
155LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96686481
156FLI1_21867929_ChIP-Seq_CD8_Mouse0.94949422
157NFYB_21822215_ChIP-Seq_K562_Human0.94048714
158OCT4_18555785_Chip-Seq_ESCs_Mouse0.93805021
159KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.93792343
160PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93782429
161ELF1_20517297_ChIP-Seq_JURKAT_Human0.93114937
162P53_22387025_ChIP-Seq_ESCs_Mouse0.91907887
163* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90936288
164SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90533628
165BCOR_27268052_Chip-Seq_Bcells_Human0.90441245
166* CTCF_20526341_ChIP-Seq_ESCs_Human0.90408019
167MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90302666
168* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90073625
169CMYC_18555785_Chip-Seq_ESCs_Mouse0.89932578
170SOX9_26525672_Chip-Seq_HEART_Mouse0.89786296
171NANOG_20526341_ChIP-Seq_ESCs_Human0.89406121
172* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88396467
173ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87666840
174GF1B_26923725_Chip-Seq_HPCs_Mouse0.87583999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08075879
2MP0001929_abnormal_gametogenesis5.52495583
3MP0008877_abnormal_DNA_methylation3.75316060
4MP0003136_yellow_coat_color3.57274340
5MP0002161_abnormal_fertility/fecundity3.32450315
6MP0002210_abnormal_sex_determination3.26990343
7MP0005670_abnormal_white_adipose3.11708612
8MP0001145_abnormal_male_reproductive2.77928792
9MP0000653_abnormal_sex_gland2.39834772
10MP0003880_abnormal_central_pattern2.28361112
11MP0002653_abnormal_ependyma_morphology2.19049586
12MP0006292_abnormal_olfactory_placode2.08256711
13MP0005410_abnormal_fertilization16.7690391
14MP0005084_abnormal_gallbladder_morpholo1.85902392
15MP0005645_abnormal_hypothalamus_physiol1.79503136
16MP0001485_abnormal_pinna_reflex1.74787575
17MP0000631_abnormal_neuroendocrine_gland1.74034274
18MP0002837_dystrophic_cardiac_calcinosis1.67517267
19MP0000566_synostosis1.66706564
20MP0009745_abnormal_behavioral_response1.62823028
21MP0002272_abnormal_nervous_system1.62546737
22MP0004233_abnormal_muscle_weight1.60970630
23MP0003122_maternal_imprinting1.60874299
24MP0005423_abnormal_somatic_nervous1.55986055
25MP0001501_abnormal_sleep_pattern1.54053008
26MP0002572_abnormal_emotion/affect_behav1.50055981
27MP0001486_abnormal_startle_reflex1.48047703
28MP0004859_abnormal_synaptic_plasticity1.47328132
29MP0002064_seizures1.46048433
30MP0003646_muscle_fatigue1.40276135
31MP0002160_abnormal_reproductive_system1.39719642
32MP0005646_abnormal_pituitary_gland1.38599284
33MP0002557_abnormal_social/conspecific_i1.38150722
34MP0000013_abnormal_adipose_tissue1.37786861
35MP0005623_abnormal_meninges_morphology1.34800423
36MP0002733_abnormal_thermal_nociception1.33502978
37MP0000955_abnormal_spinal_cord1.32384904
38MP0000026_abnormal_inner_ear1.32116861
39MP0003635_abnormal_synaptic_transmissio1.29989941
40MP0001905_abnormal_dopamine_level1.29449717
41MP0001970_abnormal_pain_threshold1.28370825
42MP0002822_catalepsy1.28170924
43MP0008872_abnormal_physiological_respon1.26858682
44MP0003787_abnormal_imprinting1.23930917
45MP0001963_abnormal_hearing_physiology1.21125299
46MP0006276_abnormal_autonomic_nervous1.20864991
47MP0003718_maternal_effect1.20490809
48MP0005394_taste/olfaction_phenotype1.20263550
49MP0005499_abnormal_olfactory_system1.20263550
50MP0002067_abnormal_sensory_capabilities1.18390870
51MP0002735_abnormal_chemical_nociception1.17301957
52MP0002063_abnormal_learning/memory/cond1.16595176
53MP0002282_abnormal_trachea_morphology1.15392609
54MP0001765_abnormal_ion_homeostasis1.12705812
55MP0009780_abnormal_chondrocyte_physiolo1.12521913
56MP0006072_abnormal_retinal_apoptosis1.10548717
57MP0002234_abnormal_pharynx_morphology1.06924246
58MP0000778_abnormal_nervous_system1.04143915
59MP0002138_abnormal_hepatobiliary_system1.03181198
60MP0001984_abnormal_olfaction1.02076873
61MP0002734_abnormal_mechanical_nocicepti1.01922578
62MP0002249_abnormal_larynx_morphology1.01841310
63MP0000383_abnormal_hair_follicle1.00702361
64MP0003195_calcinosis1.00321326
65MP0008789_abnormal_olfactory_epithelium0.99767412
66MP0002277_abnormal_respiratory_mucosa0.98404737
67MP0001944_abnormal_pancreas_morphology0.98312417
68MP0002909_abnormal_adrenal_gland0.97755512
69MP0004142_abnormal_muscle_tone0.96659995
70MP0003137_abnormal_impulse_conducting0.95712969
71MP0002882_abnormal_neuron_morphology0.94645714
72MP0005379_endocrine/exocrine_gland_phen0.91661683
73MP0000049_abnormal_middle_ear0.91650520
74MP0001529_abnormal_vocalization0.91331656
75MP0005174_abnormal_tail_pigmentation0.90755093
76MP0004885_abnormal_endolymph0.90521092
77MP0003121_genomic_imprinting0.89813536
78MP0004085_abnormal_heartbeat0.89548301
79MP0001502_abnormal_circadian_rhythm0.85588702
80MP0002876_abnormal_thyroid_physiology0.85415817
81MP0003890_abnormal_embryonic-extraembry0.85051978
82MP0003567_abnormal_fetal_cardiomyocyte0.84776842
83MP0002752_abnormal_somatic_nervous0.83198210
84MP0002638_abnormal_pupillary_reflex0.80537992
85MP0005647_abnormal_sex_gland0.78908580
86MP0008058_abnormal_DNA_repair0.74708287
87MP0003115_abnormal_respiratory_system0.74511215
88MP0009046_muscle_twitch0.71932439
89MP0008995_early_reproductive_senescence0.70333309
90MP0005389_reproductive_system_phenotype0.66252201
91MP0005377_hearing/vestibular/ear_phenot0.65294275
92MP0003878_abnormal_ear_physiology0.65294275
93MP0003011_delayed_dark_adaptation0.64720211
94MP0005666_abnormal_adipose_tissue0.64205091
95MP0005636_abnormal_mineral_homeostasis0.63735759
96MP0003329_amyloid_beta_deposits0.58596434
97MP0004036_abnormal_muscle_relaxation0.55004899
98MP0002269_muscular_atrophy0.53998478
99MP0001324_abnormal_eye_pigmentation0.53543775
100MP0002736_abnormal_nociception_after0.53290325
101MP0001764_abnormal_homeostasis0.48024327
102MP0000358_abnormal_cell_content/0.47034998
103MP0001293_anophthalmia0.45765958
104MP0000534_abnormal_ureter_morphology0.44692034
105MP0003699_abnormal_female_reproductive0.43367643
106MP0000569_abnormal_digit_pigmentation0.40568894
107MP0002928_abnormal_bile_duct0.39740636
108MP0005253_abnormal_eye_physiology0.39009285
109MP0009115_abnormal_fat_cell0.38342127
110MP0005551_abnormal_eye_electrophysiolog0.38290764
111MP0010094_abnormal_chromosome_stability0.37325565
112MP0006036_abnormal_mitochondrial_physio0.37151297
113MP0003950_abnormal_plasma_membrane0.34790327
114MP0002102_abnormal_ear_morphology0.34488817
115MP0005397_hematopoietic_system_phenotyp0.33444291
116MP0001545_abnormal_hematopoietic_system0.33444291
117MP0003942_abnormal_urinary_system0.33145669
118MP0004133_heterotaxia0.32964459
119MP0009278_abnormal_bone_marrow0.32781085
120MP0001968_abnormal_touch/_nociception0.31443840
121MP0002971_abnormal_brown_adipose0.31382710
122MP0005391_vision/eye_phenotype0.29793918
123MP0003633_abnormal_nervous_system0.29152097
124MP0004811_abnormal_neuron_physiology0.29060917
125MP0000604_amyloidosis0.28988303
126MP0002139_abnormal_hepatobiliary_system0.27967157
127MP0001730_embryonic_growth_arrest0.27028319
128MP0003111_abnormal_nucleus_morphology0.26817260
129MP0003861_abnormal_nervous_system0.25156225
130MP0003631_nervous_system_phenotype0.23097909
131MP0001849_ear_inflammation0.23012180
132MP0002152_abnormal_brain_morphology0.22769349
133MP0002169_no_abnormal_phenotype0.22697285
134MP0002873_normal_phenotype0.22504529
135MP0003948_abnormal_gas_homeostasis0.22289659
136MP0003879_abnormal_hair_cell0.22007382
137MP0001119_abnormal_female_reproductive0.21625636
138MP0002295_abnormal_pulmonary_circulatio0.21155623
139MP0004742_abnormal_vestibular_system0.20797757
140MP0006035_abnormal_mitochondrial_morpho0.20770493
141MP0004019_abnormal_vitamin_homeostasis0.20503163
142MP0005375_adipose_tissue_phenotype0.20265077
143MP0004145_abnormal_muscle_electrophysio0.19667691
144MP0004270_analgesia0.18589960
145MP0000751_myopathy0.17223127
146MP0002092_abnormal_eye_morphology0.16938585
147MP0008569_lethality_at_weaning0.16056498
148MP0004043_abnormal_pH_regulation0.16025595
149MP0005319_abnormal_enzyme/_coenzyme0.14290510
150MP0008961_abnormal_basal_metabolism0.14002810
151MP0000001_mammalian_phenotype0.13794221
152MP0002229_neurodegeneration0.13775990
153MP0002084_abnormal_developmental_patter0.13774385
154MP0003959_abnormal_lean_body0.13694435
155MP0010307_abnormal_tumor_latency0.13399464
156MP0005503_abnormal_tendon_morphology0.13393980
157MP0002693_abnormal_pancreas_physiology0.13249412
158MP0002118_abnormal_lipid_homeostasis0.13158766
159MP0008875_abnormal_xenobiotic_pharmacok0.12783524
160MP0003279_aneurysm0.12709674
161MP0005365_abnormal_bile_salt0.12686203
162MP0003786_premature_aging0.12351274
163MP0001348_abnormal_lacrimal_gland0.12343456
164MP0000462_abnormal_digestive_system0.11694413
165MP0005195_abnormal_posterior_eye0.11489249
166MP0001661_extended_life_span0.11227567

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.39717218
2Abnormal respiratory epithelium morphology (HP:0012253)9.39717218
3Abnormal respiratory motile cilium physiology (HP:0012261)9.28887790
4Chronic bronchitis (HP:0004469)7.39289870
5Rhinitis (HP:0012384)7.39183938
6Abnormal ciliary motility (HP:0012262)7.26847497
7Infertility (HP:0000789)7.07419889
8Nasal polyposis (HP:0100582)6.40408382
9Abnormality of the nasal mucosa (HP:0000433)5.27006280
10Male infertility (HP:0003251)4.91733958
11Bronchitis (HP:0012387)4.58106093
12Pancreatic cysts (HP:0001737)4.43732978
13Pancreatic fibrosis (HP:0100732)4.37075146
14Bronchiectasis (HP:0002110)4.35186984
15True hermaphroditism (HP:0010459)4.34668109
16Nephronophthisis (HP:0000090)3.94486419
17Abnormal spermatogenesis (HP:0008669)3.67773790
18Limb dystonia (HP:0002451)3.35961135
19Recurrent otitis media (HP:0000403)3.26952771
20Recurrent sinusitis (HP:0011108)3.23477738
21Chronic hepatic failure (HP:0100626)3.06378276
22Abnormality of the renal medulla (HP:0100957)2.95491710
23Sclerocornea (HP:0000647)2.77569739
24Impulsivity (HP:0100710)2.75433032
25Tubulointerstitial nephritis (HP:0001970)2.71720294
26Severe visual impairment (HP:0001141)2.71449198
27Recurrent bronchitis (HP:0002837)2.70650241
28Occipital encephalocele (HP:0002085)2.66564958
29Anencephaly (HP:0002323)2.62011003
30Abnormal gallbladder physiology (HP:0012438)2.54458280
31Cholecystitis (HP:0001082)2.54458280
32Aplasia/Hypoplasia of the spleen (HP:0010451)2.51529216
33Abnormal rod and cone electroretinograms (HP:0008323)2.49287511
34Tubular atrophy (HP:0000092)2.45834252
35Medial flaring of the eyebrow (HP:0010747)2.43901173
36Abnormality of midbrain morphology (HP:0002418)2.41545102
37Molar tooth sign on MRI (HP:0002419)2.41545102
38Abnormal pancreas size (HP:0012094)2.41052495
39Bony spicule pigmentary retinopathy (HP:0007737)2.40275408
40Genital tract atresia (HP:0001827)2.38972325
41Asplenia (HP:0001746)2.36075395
42Reticulocytopenia (HP:0001896)2.32959781
43Tubulointerstitial abnormality (HP:0001969)2.29192249
44Gonadotropin excess (HP:0000837)2.28115700
45Azoospermia (HP:0000027)2.26706964
46Febrile seizures (HP:0002373)2.25999238
47Progressive cerebellar ataxia (HP:0002073)2.21344203
48Polyuria (HP:0000103)2.20440968
49Dyschromatopsia (HP:0007641)2.18288237
50Focal motor seizures (HP:0011153)2.15221944
51Male pseudohermaphroditism (HP:0000037)2.12549668
52Anophthalmia (HP:0000528)2.10852581
53Optic nerve hypoplasia (HP:0000609)2.06825882
54Atonic seizures (HP:0010819)2.05245400
55Abnormality of macular pigmentation (HP:0008002)2.05138403
56Supernumerary spleens (HP:0009799)2.04282359
57Abnormality of the renal collecting system (HP:0004742)2.02883424
58Facial shape deformation (HP:0011334)2.02690817
59Potter facies (HP:0002009)2.02690817
60Dynein arm defect of respiratory motile cilia (HP:0012255)13.6075447
61Absent/shortened dynein arms (HP:0200106)13.6075447
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9421627
63Spastic tetraparesis (HP:0001285)1.99590993
64Choroideremia (HP:0001139)1.99264176
65Septo-optic dysplasia (HP:0100842)1.96171950
66Optic nerve coloboma (HP:0000588)1.95113783
67Aplasia/Hypoplasia of the tongue (HP:0010295)1.93954555
68Duplicated collecting system (HP:0000081)1.93756223
69Intestinal atresia (HP:0011100)1.93422273
70Decreased central vision (HP:0007663)1.92629759
71Bifid tongue (HP:0010297)1.90638905
72Attenuation of retinal blood vessels (HP:0007843)1.88788907
73Postural instability (HP:0002172)1.88280179
74Congenital stationary night blindness (HP:0007642)1.88216423
75Tubulointerstitial fibrosis (HP:0005576)1.82757414
76Poor coordination (HP:0002370)1.82414954
77Abnormality of the labia minora (HP:0012880)1.82403020
78Hyperkalemia (HP:0002153)1.79819240
79Heterotopia (HP:0002282)1.77468101
80Myokymia (HP:0002411)1.76531133
81Multicystic kidney dysplasia (HP:0000003)1.74948547
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73977825
83Hemorrhage of the eye (HP:0011885)1.73891719
84Focal seizures (HP:0007359)1.72338210
85Double outlet right ventricle (HP:0001719)1.71812045
86Congenital malformation of the right heart (HP:0011723)1.71812045
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.70741614
88Stage 5 chronic kidney disease (HP:0003774)1.68359534
89Neurofibrillary tangles (HP:0002185)1.68234572
90Postaxial foot polydactyly (HP:0001830)1.66702508
91Bile duct proliferation (HP:0001408)1.64586614
92Abnormal biliary tract physiology (HP:0012439)1.64586614
93Asymmetric septal hypertrophy (HP:0001670)1.62848839
94Decreased circulating renin level (HP:0003351)1.62691728
95Abnormal drinking behavior (HP:0030082)1.62317322
96Polydipsia (HP:0001959)1.62317322
97Furrowed tongue (HP:0000221)1.60973073
98Dialeptic seizures (HP:0011146)1.60724571
99Aplasia/Hypoplasia of the lens (HP:0008063)1.60234348
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.58685018
101Impaired smooth pursuit (HP:0007772)1.58578510
102Preaxial hand polydactyly (HP:0001177)1.58247484
103Type II lissencephaly (HP:0007260)1.57917953
104Abnormality of renal excretion (HP:0011036)1.56545324
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.56144078
106Absent rod-and cone-mediated responses on ERG (HP:0007688)1.55872714
107Prominent nasal bridge (HP:0000426)1.55411697
108Bell-shaped thorax (HP:0001591)1.54914369
109Gastrointestinal atresia (HP:0002589)1.54484656
110Congenital hepatic fibrosis (HP:0002612)1.54225345
111Bundle branch block (HP:0011710)1.52339231
112Short ribs (HP:0000773)1.49935497
113Abnormality of the renal cortex (HP:0011035)1.47590580
114Easy fatigability (HP:0003388)1.46024237
115Congenital primary aphakia (HP:0007707)1.42584106
116Abnormality of dentin (HP:0010299)1.41320935
117Gait imbalance (HP:0002141)1.41271028
118Oculomotor apraxia (HP:0000657)1.40357242
119Abnormality of permanent molar morphology (HP:0011071)1.39230681
120Abnormality of the dental root (HP:0006486)1.39230681
121Taurodontia (HP:0000679)1.39230681
122Cerebral inclusion bodies (HP:0100314)1.39112006
123Abnormality of the neuromuscular junction (HP:0003398)1.38835255
124Fatigable weakness (HP:0003473)1.38835255
125Postaxial hand polydactyly (HP:0001162)1.38555927
126Sensory axonal neuropathy (HP:0003390)1.38482978
127Exercise-induced myalgia (HP:0003738)1.37720882
128Renal dysplasia (HP:0000110)1.34701221
129Constricted visual fields (HP:0001133)1.34288732
130Chronic sinusitis (HP:0011109)1.33740352
131Myoglobinuria (HP:0002913)1.31659777
132Abnormality of the dental pulp (HP:0006479)1.30169095
133Facial cleft (HP:0002006)1.30162052
134Hypercholesterolemia (HP:0003124)1.29841032
135Abnormal urine output (HP:0012590)1.29682233
136Cystic liver disease (HP:0006706)1.29358776
137Hemiparesis (HP:0001269)1.29190299
138Cerebellar dysplasia (HP:0007033)1.28807528
139Abnormality of molar (HP:0011077)1.28111007
140Abnormality of molar morphology (HP:0011070)1.28111007
141Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.26084743
142Fibular hypoplasia (HP:0003038)1.25930148
143Deformed sella turcica (HP:0002681)1.23875634
144Loss of speech (HP:0002371)1.22608777
145Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.22024211
146Absent epiphyses (HP:0010577)1.22024211
147Truncal obesity (HP:0001956)1.18824408
148Rhabdomyolysis (HP:0003201)1.17672019
149Nephrogenic diabetes insipidus (HP:0009806)1.17421205
150Abnormality of saccadic eye movements (HP:0000570)1.17355124
151Neoplasm of the heart (HP:0100544)1.17038725
152Type 2 muscle fiber atrophy (HP:0003554)1.14907118
153Vaginal atresia (HP:0000148)1.14886204
154Generalized muscle weakness (HP:0003324)1.14608009
155Broad distal phalanx of finger (HP:0009836)1.12881541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.11494922
2PDK38.11494922
3TESK16.47367593
4PDK25.24904533
5PRKD35.19487064
6ICK4.64154632
7MAP3K43.43521929
8MAP4K23.34806788
9ADRBK22.40251852
10CASK2.30636070
11TNIK2.22275366
12NTRK32.16582279
13WNK42.08819270
14TAOK32.08556366
15PTK2B2.08534415
16GRK12.07962178
17STK392.00885018
18MAPK131.83599910
19STK381.82066482
20FRK1.76889946
21INSRR1.75656613
22DYRK1B1.73768713
23PNCK1.72772242
24BRD41.68035679
25BMPR1B1.63106669
26MAPKAPK31.57863649
27DAPK21.52926380
28NEK21.51067354
29PLK21.50306716
30MAP2K71.47474483
31MAP2K41.37630065
32DDR21.31757016
33MARK11.25376842
34PDK11.25151039
35ZAK1.22532511
36MAP3K61.17697719
37MAP3K21.17095554
38DYRK21.08836138
39TLK11.07646649
40BCKDK1.05209210
41FGFR21.02594759
42WNK31.00969061
43DYRK1A0.98281833
44SGK2230.97811052
45SGK4940.97811052
46ACVR1B0.97522667
47SGK20.97444046
48MAP3K110.95929402
49NLK0.91649807
50OXSR10.91172453
51DYRK30.87761494
52IRAK10.87507700
53MAP2K20.86785009
54TYRO30.86775066
55PDPK10.81334753
56RPS6KA20.80921784
57MAPK150.77935919
58WNK10.77374493
59TXK0.76801051
60SGK10.76517626
61RIPK40.76427236
62EPHA40.75048112
63TESK20.74347630
64PHKG10.73984648
65PHKG20.73984648
66PRKCE0.72757106
67AKT30.72588781
68GRK60.72127815
69EEF2K0.69218069
70PASK0.68903131
71MINK10.67089333
72CCNB10.64677507
73RPS6KA40.62196275
74MAP2K60.59326494
75ADRBK10.59250731
76CDK30.58400919
77STK30.57768578
78LMTK20.57694159
79CHEK20.57460615
80PAK30.54178509
81TTK0.53536807
82NUAK10.52773654
83CAMK1G0.49774337
84PINK10.49503747
85MAP3K70.48761301
86CAMK10.48401094
87TNK20.47960295
88IRAK20.47617873
89PRKACA0.46168749
90MST40.46105603
91NTRK20.43344099
92PRKAA20.43096841
93EPHA30.43015015
94MUSK0.42784187
95KSR10.42767376
96PAK10.41833105
97PRKCI0.41064870
98STK38L0.39324081
99CDK50.38905616
100FGFR30.38889260
101CSNK1G20.37673225
102MAP3K100.36768766
103CHEK10.36308696
104PRKCG0.36159149
105MAPKAPK50.35877447
106RPS6KA60.34769232
107PAK20.31714934
108CSNK1G10.30832905
109TBK10.29145394
110PAK40.29085325
111TRIM280.28980438
112VRK10.28199080
113MARK20.28115189
114FGFR10.27907296
115PLK40.26978411
116MTOR0.25040420
117CAMKK10.23857159
118ATM0.23711459
119PRKCZ0.20618142
120CDK150.19417376
121BRSK20.18597044
122ATR0.17958320
123WEE10.17379093
124CDK180.16541963
125PRKAA10.16398147
126CDK11A0.15268843
127NEK60.14823261
128PRKCQ0.14375657
129PRKG20.12963919
130CDK140.11515031
131RPS6KB10.11289586
132PLK10.10725431
133BRSK10.10697646
134CDC70.09364048
135CDK120.09341669
136RPS6KA10.08522698
137MARK30.07848689
138CDK60.07378984
139GSK3B0.06871655
140CSNK2A10.06671342
141PKN10.06293053
142STK100.04886308
143BRAF0.04273394
144PRKG10.03682044
145CAMK2A0.03395147
146CSNK1D0.03233198
147PRKACG0.03132712
148STK110.03105076
149TRIB30.02948587
150PRKCD0.02946150
151CSF1R0.02391482
152CSNK2A20.02106601
153CDK20.02056222
154PRKCB0.01698841
155CDK10.01553570
156MAPK80.01545259
157PIM10.01161675
158PRKCA0.00823481
159EGFR0.00805526
160YES10.00662413
161PDGFRB0.00442554
162RIPK10.00016329
163PRKACB-0.0234719
164RPS6KA3-0.0216905
165CDK4-0.0193276
166MAP3K1-0.0135819
167PAK6-0.0116790
168AURKA-0.0010843
169EPHB1-0.0004293
170CLK1-0.0001301

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.79397154
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.57085660
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.82606898
4Pyruvate metabolism_Homo sapiens_hsa006203.27991974
5Vitamin B6 metabolism_Homo sapiens_hsa007503.24550881
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.16375576
7Linoleic acid metabolism_Homo sapiens_hsa005913.05211924
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.97337954
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.89788446
10Glucagon signaling pathway_Homo sapiens_hsa049222.50884320
11Propanoate metabolism_Homo sapiens_hsa006402.48456466
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.47171407
13Nicotine addiction_Homo sapiens_hsa050332.39655173
14Olfactory transduction_Homo sapiens_hsa047402.38317556
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.32172057
16Butanoate metabolism_Homo sapiens_hsa006502.27706124
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23756037
18Basal transcription factors_Homo sapiens_hsa030222.14522859
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.08720439
20Phototransduction_Homo sapiens_hsa047442.01527637
21Glycerolipid metabolism_Homo sapiens_hsa005611.97779092
22Selenocompound metabolism_Homo sapiens_hsa004501.97304045
23PPAR signaling pathway_Homo sapiens_hsa033201.92675483
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.90269524
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77938182
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.71502544
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.68650097
28Fructose and mannose metabolism_Homo sapiens_hsa000511.65578634
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.65227227
30Mineral absorption_Homo sapiens_hsa049781.62746285
31Oocyte meiosis_Homo sapiens_hsa041141.58982181
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58961902
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.55488286
34GABAergic synapse_Homo sapiens_hsa047271.52460440
35Fat digestion and absorption_Homo sapiens_hsa049751.51717384
36Fatty acid metabolism_Homo sapiens_hsa012121.50572724
37Fatty acid degradation_Homo sapiens_hsa000711.49328018
38Pentose phosphate pathway_Homo sapiens_hsa000301.45882481
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45496473
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44727917
41Ether lipid metabolism_Homo sapiens_hsa005651.44560189
42Amphetamine addiction_Homo sapiens_hsa050311.43600919
43Glutamatergic synapse_Homo sapiens_hsa047241.42114437
44Retinol metabolism_Homo sapiens_hsa008301.39696835
45Carbon metabolism_Homo sapiens_hsa012001.39517128
46Histidine metabolism_Homo sapiens_hsa003401.38286388
47Phenylalanine metabolism_Homo sapiens_hsa003601.35639404
48Dorso-ventral axis formation_Homo sapiens_hsa043201.34817721
49Morphine addiction_Homo sapiens_hsa050321.34612319
50Serotonergic synapse_Homo sapiens_hsa047261.34001831
51Cardiac muscle contraction_Homo sapiens_hsa042601.33068119
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29895247
53Dopaminergic synapse_Homo sapiens_hsa047281.25506757
54beta-Alanine metabolism_Homo sapiens_hsa004101.24675839
55Regulation of autophagy_Homo sapiens_hsa041401.20179038
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13620367
57Tyrosine metabolism_Homo sapiens_hsa003501.12888842
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11279334
59Antigen processing and presentation_Homo sapiens_hsa046121.05794057
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05693935
61Peroxisome_Homo sapiens_hsa041461.05325613
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.05321240
63Hedgehog signaling pathway_Homo sapiens_hsa043401.03129609
64Glutathione metabolism_Homo sapiens_hsa004801.01979443
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01708842
66Renin secretion_Homo sapiens_hsa049241.01513315
67Collecting duct acid secretion_Homo sapiens_hsa049661.00604140
68Purine metabolism_Homo sapiens_hsa002300.98956684
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98928084
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.96769331
71Fanconi anemia pathway_Homo sapiens_hsa034600.95874738
72Sphingolipid metabolism_Homo sapiens_hsa006000.94455765
73Vitamin digestion and absorption_Homo sapiens_hsa049770.91164585
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90853072
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.88874941
76Biosynthesis of amino acids_Homo sapiens_hsa012300.88865208
77Insulin secretion_Homo sapiens_hsa049110.87826007
78Huntingtons disease_Homo sapiens_hsa050160.86220570
79mRNA surveillance pathway_Homo sapiens_hsa030150.85768322
80Chemical carcinogenesis_Homo sapiens_hsa052040.84956887
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84429514
82Oxidative phosphorylation_Homo sapiens_hsa001900.84281117
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.83902638
84Bile secretion_Homo sapiens_hsa049760.83247091
85Arachidonic acid metabolism_Homo sapiens_hsa005900.80094674
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80083322
87Thyroid hormone synthesis_Homo sapiens_hsa049180.79602873
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76842859
89Estrogen signaling pathway_Homo sapiens_hsa049150.74829662
90Caffeine metabolism_Homo sapiens_hsa002320.73969614
91Tryptophan metabolism_Homo sapiens_hsa003800.72576429
92Cholinergic synapse_Homo sapiens_hsa047250.70254169
93RNA transport_Homo sapiens_hsa030130.70065461
94Long-term potentiation_Homo sapiens_hsa047200.69061615
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68472573
96Steroid biosynthesis_Homo sapiens_hsa001000.67549548
97Type II diabetes mellitus_Homo sapiens_hsa049300.65269348
98Nitrogen metabolism_Homo sapiens_hsa009100.64197211
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63524766
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.61789721
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60017942
102Legionellosis_Homo sapiens_hsa051340.58786273
103Pancreatic secretion_Homo sapiens_hsa049720.58577533
104Circadian rhythm_Homo sapiens_hsa047100.57571121
105Protein digestion and absorption_Homo sapiens_hsa049740.57323080
106Salivary secretion_Homo sapiens_hsa049700.56439795
107Parkinsons disease_Homo sapiens_hsa050120.55357627
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54965239
109Renin-angiotensin system_Homo sapiens_hsa046140.54649692
110Tight junction_Homo sapiens_hsa045300.53968742
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53663280
112Synaptic vesicle cycle_Homo sapiens_hsa047210.53048150
113Systemic lupus erythematosus_Homo sapiens_hsa053220.52143746
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51895100
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50980542
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48832690
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48391788
118Gastric acid secretion_Homo sapiens_hsa049710.48321354
119Calcium signaling pathway_Homo sapiens_hsa040200.48055231
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45943823
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45768864
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.45547254
123Endocytosis_Homo sapiens_hsa041440.44606033
124ABC transporters_Homo sapiens_hsa020100.44115077
125Protein export_Homo sapiens_hsa030600.41875173
126Inositol phosphate metabolism_Homo sapiens_hsa005620.41617098
127AMPK signaling pathway_Homo sapiens_hsa041520.41429700
128Arginine and proline metabolism_Homo sapiens_hsa003300.39957993
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39833362
130RNA degradation_Homo sapiens_hsa030180.39796062
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39075009
132Sulfur metabolism_Homo sapiens_hsa009200.38777188
133Metabolic pathways_Homo sapiens_hsa011000.38075407
134Type I diabetes mellitus_Homo sapiens_hsa049400.35592938
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35307883
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35048794
137Oxytocin signaling pathway_Homo sapiens_hsa049210.34027403
138VEGF signaling pathway_Homo sapiens_hsa043700.32614572
139Notch signaling pathway_Homo sapiens_hsa043300.31399386
140cAMP signaling pathway_Homo sapiens_hsa040240.30781923
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30258131
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29603108
143Pyrimidine metabolism_Homo sapiens_hsa002400.27232055
144Taste transduction_Homo sapiens_hsa047420.26505067
145Circadian entrainment_Homo sapiens_hsa047130.25682711
146Alcoholism_Homo sapiens_hsa050340.25137379
147Cocaine addiction_Homo sapiens_hsa050300.19943411
148Basal cell carcinoma_Homo sapiens_hsa052170.13272670
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12487208
150N-Glycan biosynthesis_Homo sapiens_hsa005100.11604294
151HIF-1 signaling pathway_Homo sapiens_hsa040660.11587291
152Wnt signaling pathway_Homo sapiens_hsa043100.10666381
153Salmonella infection_Homo sapiens_hsa051320.06633929
154B cell receptor signaling pathway_Homo sapiens_hsa046620.05035503
155Insulin resistance_Homo sapiens_hsa049310.01821162

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