CDS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.74391009
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.79841606
3epithelial cilium movement (GO:0003351)8.54066810
4vitamin transmembrane transport (GO:0035461)6.46730686
5axoneme assembly (GO:0035082)6.10494488
6primary alcohol catabolic process (GO:0034310)6.07986499
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.59378920
8left/right pattern formation (GO:0060972)5.49494587
9desmosome organization (GO:0002934)5.13608031
10diterpenoid biosynthetic process (GO:0016102)5.01167700
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.91652746
12pyrimidine-containing compound transmembrane transport (GO:0072531)4.89416177
13ethanol metabolic process (GO:0006067)4.87899092
14vocalization behavior (GO:0071625)4.84512944
15synaptic vesicle maturation (GO:0016188)4.76573576
16regulation of cilium movement (GO:0003352)4.72087282
17glutamate secretion (GO:0014047)4.67801516
18cellular potassium ion homeostasis (GO:0030007)4.64627493
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.60410629
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.58334638
21synaptic vesicle exocytosis (GO:0016079)4.56325896
22multicellular organismal water homeostasis (GO:0050891)4.53869214
23left/right axis specification (GO:0070986)4.51572279
24regulation of synaptic vesicle exocytosis (GO:2000300)4.45176015
25locomotory exploration behavior (GO:0035641)4.40469898
26sodium ion export (GO:0071436)4.32970981
27apical protein localization (GO:0045176)4.27759777
28neuronal action potential propagation (GO:0019227)4.24359513
29intestinal epithelial cell development (GO:0060576)4.19465129
30ventricular system development (GO:0021591)4.19121975
31phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.12311399
32ionotropic glutamate receptor signaling pathway (GO:0035235)4.10532784
33bundle of His cell to Purkinje myocyte communication (GO:0086069)4.06881298
34regulation of synaptic vesicle transport (GO:1902803)4.06268518
35microtubule bundle formation (GO:0001578)4.01169185
36establishment of apical/basal cell polarity (GO:0035089)3.99802029
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.97978561
38protein localization to synapse (GO:0035418)3.92618905
39sperm capacitation (GO:0048240)3.92197758
40lung epithelium development (GO:0060428)3.92033985
41sodium ion homeostasis (GO:0055078)3.90442396
42water homeostasis (GO:0030104)3.81892652
43calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.79606033
44neurotransmitter secretion (GO:0007269)3.79531941
45regulation of water loss via skin (GO:0033561)3.75802867
46glutamate receptor signaling pathway (GO:0007215)3.72135735
47regulation of glutamate receptor signaling pathway (GO:1900449)3.71424392
48O-glycan processing (GO:0016266)3.69479445
49sphingomyelin metabolic process (GO:0006684)3.69374729
50ethanol oxidation (GO:0006069)3.67981342
51intraciliary transport (GO:0042073)3.64719272
52synaptic transmission, glutamatergic (GO:0035249)3.61927124
53proline transport (GO:0015824)3.56269646
54one-carbon compound transport (GO:0019755)3.55931380
55regulation of long-term neuronal synaptic plasticity (GO:0048169)3.50391658
56regulation of neuronal synaptic plasticity (GO:0048168)3.49985395
57neuron-neuron synaptic transmission (GO:0007270)3.49355579
58exploration behavior (GO:0035640)3.48946772
59terpenoid biosynthetic process (GO:0016114)3.48344098
60establishment of skin barrier (GO:0061436)3.47182282
61establishment of planar polarity (GO:0001736)3.46900734
62establishment of tissue polarity (GO:0007164)3.46900734
63cilium organization (GO:0044782)3.46711600
64retinoic acid metabolic process (GO:0042573)3.45387723
65regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.43181805
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.40602779
67regulation of clathrin-mediated endocytosis (GO:2000369)3.38699946
68negative regulation of T cell differentiation in thymus (GO:0033085)3.38317261
69retinol metabolic process (GO:0042572)3.37709402
70cilium assembly (GO:0042384)3.37562211
71keratinocyte proliferation (GO:0043616)3.36246164
72neurotransmitter transport (GO:0006836)3.36164472
73layer formation in cerebral cortex (GO:0021819)3.34071713
74asymmetric protein localization (GO:0008105)3.33938372
75regulation of interleukin-5 production (GO:0032674)3.32886177
76response to histamine (GO:0034776)3.32425097
77gamma-aminobutyric acid signaling pathway (GO:0007214)3.27370132
78chemosensory behavior (GO:0007635)3.27252139
79cerebellar Purkinje cell differentiation (GO:0021702)3.26306151
80primary alcohol metabolic process (GO:0034308)3.25151871
81establishment or maintenance of monopolar cell polarity (GO:0061339)3.25066716
82establishment of monopolar cell polarity (GO:0061162)3.25066716
83neuron cell-cell adhesion (GO:0007158)3.24421045
84long-term memory (GO:0007616)3.23289893
85regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22750162
86synaptic vesicle endocytosis (GO:0048488)3.21781864
87glomerular epithelial cell development (GO:0072310)3.21645789
88membrane hyperpolarization (GO:0060081)3.17175463
89calcium ion-dependent exocytosis (GO:0017156)3.16981115
90long-term synaptic potentiation (GO:0060291)3.15524745
91cerebellar granule cell differentiation (GO:0021707)3.14099140
92regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.13885500
93glutathione derivative metabolic process (GO:1901685)3.12929894
94glutathione derivative biosynthetic process (GO:1901687)3.12929894
95microtubule-based movement (GO:0007018)3.12762922
96positive regulation of synapse maturation (GO:0090129)3.12735008
97potassium ion homeostasis (GO:0055075)3.12226508
98regulation of interleukin-13 production (GO:0032656)3.11953908
99negative regulation of hormone metabolic process (GO:0032351)3.11561416
100negative regulation of hormone biosynthetic process (GO:0032353)3.11561416
101regulation of postsynaptic membrane potential (GO:0060078)3.11166660
102hemidesmosome assembly (GO:0031581)3.11153322
103regulation of neurotransmitter secretion (GO:0046928)3.10765071
104regulation of guanylate cyclase activity (GO:0031282)3.09653346
105positive regulation of guanylate cyclase activity (GO:0031284)3.08678729
106activation of protein kinase A activity (GO:0034199)3.08516680
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07772219
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.07249680
109negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.07182631
110positive regulation of membrane potential (GO:0045838)3.06505335
111regulation of synaptic plasticity (GO:0048167)3.06489480
112membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.05931585
113positive regulation of neurotransmitter transport (GO:0051590)3.05454900
114centriole assembly (GO:0098534)3.05021171
115positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03797900
116regulation of voltage-gated calcium channel activity (GO:1901385)3.02779361
117potassium ion import (GO:0010107)3.02359254
118protein targeting to Golgi (GO:0000042)3.01299284
119membrane depolarization during action potential (GO:0086010)3.00699880
120tight junction assembly (GO:0070830)2.99733412
121regulation of microtubule-based movement (GO:0060632)2.99339744
122response to xenobiotic stimulus (GO:0009410)2.99071198
123neuromuscular process controlling posture (GO:0050884)2.97638373
124cellular sodium ion homeostasis (GO:0006883)2.97061216
125gamma-aminobutyric acid transport (GO:0015812)2.96355096
126positive regulation of neurotransmitter secretion (GO:0001956)2.95744730
127glycine transport (GO:0015816)2.95065304
128negative regulation of inclusion body assembly (GO:0090084)2.94362003
129regulation of rhodopsin mediated signaling pathway (GO:0022400)2.92944426
130cell communication by electrical coupling (GO:0010644)2.91620605
131vesicle transport along microtubule (GO:0047496)2.90744239
132membrane repolarization during action potential (GO:0086011)2.89674249
133G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89568668
134filopodium assembly (GO:0046847)2.87688792
135rhodopsin mediated signaling pathway (GO:0016056)2.87629916
136long term synaptic depression (GO:0060292)2.86474952
137regulation of sodium ion transmembrane transporter activity (GO:2000649)2.85427840
138regulation of neurotransmitter levels (GO:0001505)2.85381046
139positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.83735875
140cell projection assembly (GO:0030031)2.83417447
141innervation (GO:0060384)2.83307095
142membrane repolarization (GO:0086009)2.82614072
143cell communication involved in cardiac conduction (GO:0086065)2.80786558
144establishment of protein localization to Golgi (GO:0072600)2.80480984
145regulation of neurotransmitter transport (GO:0051588)2.80345282
146neuron recognition (GO:0008038)2.79420637
147membrane depolarization (GO:0051899)2.79116217
148regulation of vesicle fusion (GO:0031338)2.76417206
149retinal cone cell development (GO:0046549)2.73690415
150acid secretion (GO:0046717)2.73224237
151excretion (GO:0007588)2.72857718
152neuromuscular process controlling balance (GO:0050885)2.71545185
153dendritic spine morphogenesis (GO:0060997)2.69973860
154cytoskeletal anchoring at plasma membrane (GO:0007016)2.69778141
155regulation of synapse structural plasticity (GO:0051823)2.66465940
156neurotransmitter-gated ion channel clustering (GO:0072578)2.66269889
157positive regulation of vesicle fusion (GO:0031340)2.65086838
158NADH metabolic process (GO:0006734)2.63412387
159cardiac conduction (GO:0061337)2.61985394
160establishment or maintenance of bipolar cell polarity (GO:0061245)2.61590088
161establishment or maintenance of apical/basal cell polarity (GO:0035088)2.61590088
162dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.61093365
163cellular component assembly involved in morphogenesis (GO:0010927)2.60705180
164protein localization to cilium (GO:0061512)2.60332440
165behavioral response to cocaine (GO:0048148)2.59919375
166detection of calcium ion (GO:0005513)2.59211785
167synaptic transmission (GO:0007268)2.59161134
168G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.57889034
169relaxation of cardiac muscle (GO:0055119)2.57609452
170carnitine metabolic process (GO:0009437)2.57397520
171phosphate ion transmembrane transport (GO:0035435)2.53906233
172oligosaccharide biosynthetic process (GO:0009312)2.51275200
173lateral sprouting from an epithelium (GO:0060601)2.51106832
174phenol-containing compound catabolic process (GO:0019336)2.50889115
175exogenous drug catabolic process (GO:0042738)2.48846165
176negative regulation of keratinocyte proliferation (GO:0010839)2.45932751
177fructose metabolic process (GO:0006000)2.45585509
178ear development (GO:0043583)2.43636902
179epoxygenase P450 pathway (GO:0019373)2.42550680
180surfactant homeostasis (GO:0043129)2.41220909
181nucleoside diphosphate phosphorylation (GO:0006165)2.41160559
182neurotransmitter biosynthetic process (GO:0042136)2.40583822
183protein O-linked glycosylation (GO:0006493)2.38587353
184cytoplasmic microtubule organization (GO:0031122)2.36643137
185cell-cell junction assembly (GO:0007043)2.35569066
186cilium morphogenesis (GO:0060271)2.35103185
187chemical homeostasis within a tissue (GO:0048875)2.33738378
188positive regulation of smoothened signaling pathway (GO:0045880)2.33631388
189L-ascorbic acid metabolic process (GO:0019852)2.30570685
190glutathione metabolic process (GO:0006749)2.30324802
191axonemal dynein complex assembly (GO:0070286)13.9967128
192cilium or flagellum-dependent cell motility (GO:0001539)11.3936753
193cilium movement (GO:0003341)10.2139138

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.04333849
2EZH2_22144423_ChIP-Seq_EOC_Human4.89002880
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.76955413
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.53630638
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.31199069
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.96858030
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.87081033
8GBX2_23144817_ChIP-Seq_PC3_Human2.75459063
9SOX2_27498859_Chip-Seq_STOMACH_Mouse2.63206350
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48832239
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46073077
12DROSHA_22980978_ChIP-Seq_HELA_Human2.39738123
13REST_21632747_ChIP-Seq_MESCs_Mouse2.31722021
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26886472
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.23764890
16ZNF263_19887448_ChIP-Seq_K562_Human2.23589432
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21311808
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17296102
19* SOX2_20726797_ChIP-Seq_SW620_Human2.14636256
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12989726
21* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12196353
22* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12196353
23FOXM1_26456572_ChIP-Seq_MCF-7_Human2.06977104
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04160043
25RUNX1_27514584_Chip-Seq_MCF-7_Human2.03836433
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.02353207
27FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.01575379
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93663362
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91190315
30* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88143177
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.87807559
32AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.80842043
33GATA3_24758297_ChIP-Seq_MCF-7_Human1.80302095
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.80006838
35* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79347241
36GATA4_25053715_ChIP-Seq_YYC3_Human1.78343756
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.77131833
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.71814033
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.67003798
40AR_21909140_ChIP-Seq_LNCAP_Human1.65315263
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64615868
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64412113
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.62222700
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61858593
45ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.61578191
46P63_26484246_Chip-Seq_KERATINOCYTES_Human1.61081877
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60160308
48RACK7_27058665_Chip-Seq_MCF-7_Human1.59948917
49* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.59341124
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58958354
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58180596
52FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.56589904
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56398287
54* GATA6_25053715_ChIP-Seq_YYC3_Human1.55014280
55* TP63_23658742_ChIP-Seq_EP156T_Human1.54670364
56SMAD4_21799915_ChIP-Seq_A2780_Human1.54114403
57* FOXA1_25552417_ChIP-Seq_VCAP_Human1.47895501
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.47881761
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46899310
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42537566
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40826197
62VDR_22108803_ChIP-Seq_LS180_Human1.40660033
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40110204
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32657667
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29875820
66CLOCK_20551151_ChIP-Seq_293T_Human1.29663921
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29533277
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28447370
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26237356
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.25840328
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25006840
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.23778595
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23717631
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23635648
75ZNF274_21170338_ChIP-Seq_K562_Hela1.23564022
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.22504852
77AHR_22903824_ChIP-Seq_MCF-7_Human1.21211739
78* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.20559694
79SMAD3_21741376_ChIP-Seq_HESCs_Human1.18736238
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17598323
81FOXA2_19822575_ChIP-Seq_HepG2_Human1.17505675
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16622023
83AR_25329375_ChIP-Seq_VCAP_Human1.15394777
84* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14915301
85AR_21572438_ChIP-Seq_LNCaP_Human1.14340785
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13721894
87TP53_18474530_ChIP-ChIP_U2OS_Human1.13655480
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.13651708
89STAT3_23295773_ChIP-Seq_U87_Human1.12919557
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.12277047
91* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11391789
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10697766
93BCAT_22108803_ChIP-Seq_LS180_Human1.10676018
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09709109
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09709109
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09015394
97* TP63_22573176_ChIP-Seq_HFKS_Human1.08781057
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07980327
99* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07808766
100RING1B_27294783_Chip-Seq_ESCs_Mouse1.07807232
101ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07362893
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.07049782
103SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06695397
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05551224
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05086202
106* AR_19668381_ChIP-Seq_PC3_Human1.05011408
107* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04707009
108KDM2B_26808549_Chip-Seq_K562_Human1.04688777
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03327995
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03135314
111* P300_19829295_ChIP-Seq_ESCs_Human1.03092664
112TAF15_26573619_Chip-Seq_HEK293_Human1.01562371
113ELF5_23300383_ChIP-Seq_T47D_Human1.01140686
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01104131
115SMC4_20622854_ChIP-Seq_HELA_Human1.00960104
116ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00173219
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.99492507
118TCF4_23295773_ChIP-Seq_U87_Human0.98438191
119* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97157639
120CREB1_26743006_Chip-Seq_LNCaP_Human0.96727643
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96303006
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96205918
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.96205847
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.95885800
125LXR_22158963_ChIP-Seq_LIVER_Mouse0.94022947
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.93886063
127NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93638226
128TP53_16413492_ChIP-PET_HCT116_Human0.92246969
129CBX2_27304074_Chip-Seq_ESCs_Mouse0.92150976
130FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91854948
131NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91155561
132RNF2_27304074_Chip-Seq_NSC_Mouse0.89954410
133TCF4_18268006_ChIP-ChIP_LS174T_Human0.89878209
134STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89634582
135ESR2_21235772_ChIP-Seq_MCF-7_Human0.89505450
136RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89034085
137PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.88168674
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87604358
139* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87449687
140CTCF_27219007_Chip-Seq_Bcells_Human0.86931677
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86898962
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86898962
143HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86404666
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86311379
145YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86127807
146RXR_22158963_ChIP-Seq_LIVER_Mouse0.86060087
147CHD1_26751641_Chip-Seq_LNCaP_Human0.86059924
148RUNX2_22187159_ChIP-Seq_PCA_Human0.85236952
149RXR_22108803_ChIP-Seq_LS180_Human0.85156808
150* TCF4_22108803_ChIP-Seq_LS180_Human0.84895408
151* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84852163
152BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84778272
153SMAD4_21741376_ChIP-Seq_EPCs_Human0.84773473
154NANOG_18555785_Chip-Seq_ESCs_Mouse0.84583925
155NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84422195
156KDM2B_26808549_Chip-Seq_REH_Human0.84413506
157ESR1_20079471_ChIP-ChIP_T-47D_Human0.83399053
158KLF5_25053715_ChIP-Seq_YYC3_Human0.83315379
159TET1_21490601_ChIP-Seq_MESCs_Mouse0.82649092
160CDX2_22108803_ChIP-Seq_LS180_Human0.81675179
161ETV1_20927104_ChIP-Seq_GIST48_Human0.79267689
162GATA1_26923725_Chip-Seq_HPCs_Mouse0.78410240
163* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.78307441
164PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78218904
165RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78058357
166TDRD3_21172665_ChIP-Seq_MCF-7_Human0.77438129
167PHF8_20622853_ChIP-Seq_HELA_Human0.77351603
168SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.77115125
169* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76572872
170ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76530164
171RBPJ_21746931_ChIP-Seq_IB4_Human0.76159655
172TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74957850
173KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74877612
174CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.73076565

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.77920582
2MP0003880_abnormal_central_pattern4.34839962
3MP0000566_synostosis4.24286041
4MP0008875_abnormal_xenobiotic_pharmacok4.07641323
5MP0004270_analgesia3.73141474
6MP0003635_abnormal_synaptic_transmissio3.69729482
7MP0010678_abnormal_skin_adnexa3.10776135
8MP0009046_muscle_twitch3.08397524
9MP0003941_abnormal_skin_development3.07344571
10MP0000579_abnormal_nail_morphology2.96041831
11MP0009745_abnormal_behavioral_response2.92935199
12MP0002063_abnormal_learning/memory/cond2.90331912
13MP0002064_seizures2.79722449
14MP0010234_abnormal_vibrissa_follicle2.73653991
15MP0001968_abnormal_touch/_nociception2.69081898
16MP0001501_abnormal_sleep_pattern2.65350395
17MP0009379_abnormal_foot_pigmentation2.60469339
18MP0000383_abnormal_hair_follicle2.60019232
19MP0005551_abnormal_eye_electrophysiolog2.54638186
20MP0002572_abnormal_emotion/affect_behav2.47660718
21MP0002272_abnormal_nervous_system2.47011030
22MP0002734_abnormal_mechanical_nocicepti2.45707742
23MP0005410_abnormal_fertilization2.31270771
24MP0001984_abnormal_olfaction2.24947176
25MP0002736_abnormal_nociception_after2.21008957
26MP0001486_abnormal_startle_reflex2.20343044
27MP0002822_catalepsy2.19828349
28MP0009780_abnormal_chondrocyte_physiolo2.16262289
29MP0002098_abnormal_vibrissa_morphology2.15742059
30MP0005423_abnormal_somatic_nervous2.12579905
31MP0002277_abnormal_respiratory_mucosa2.10821701
32MP0001440_abnormal_grooming_behavior2.10740785
33MP0003329_amyloid_beta_deposits1.94226214
34MP0003879_abnormal_hair_cell1.92218800
35MP0005501_abnormal_skin_physiology1.84766242
36MP0001666_abnormal_nutrient_absorption1.84229611
37MP0002067_abnormal_sensory_capabilities1.79317414
38MP0002909_abnormal_adrenal_gland1.79313379
39MP0008569_lethality_at_weaning1.78539807
40MP0002735_abnormal_chemical_nociception1.77258010
41MP0000678_abnormal_parathyroid_gland1.76963621
42MP0005409_darkened_coat_color1.72777460
43MP0001970_abnormal_pain_threshold1.69323589
44MP0002733_abnormal_thermal_nociception1.68986954
45MP0002132_abnormal_respiratory_system1.67339533
46MP0010352_gastrointestinal_tract_polyps1.63938923
47MP0004782_abnormal_surfactant_physiolog1.60701987
48MP0005085_abnormal_gallbladder_physiolo1.60553490
49MP0004043_abnormal_pH_regulation1.57949720
50MP0004885_abnormal_endolymph1.56647703
51MP0004858_abnormal_nervous_system1.56505097
52MP0000467_abnormal_esophagus_morphology1.55843453
53MP0003453_abnormal_keratinocyte_physiol1.53600370
54MP0001346_abnormal_lacrimal_gland1.49500688
55MP0010386_abnormal_urinary_bladder1.49334404
56MP0002557_abnormal_social/conspecific_i1.48848144
57MP0005623_abnormal_meninges_morphology1.45676543
58MP0008789_abnormal_olfactory_epithelium1.45329124
59MP0003283_abnormal_digestive_organ1.43038957
60MP0002229_neurodegeneration1.42959577
61MP0002184_abnormal_innervation1.39866557
62MP0004924_abnormal_behavior1.37945807
63MP0005386_behavior/neurological_phenoty1.37945807
64MP0005253_abnormal_eye_physiology1.35247432
65MP0002882_abnormal_neuron_morphology1.31572818
66MP0004811_abnormal_neuron_physiology1.30884925
67MP0003183_abnormal_peptide_metabolism1.30414481
68MP0003011_delayed_dark_adaptation1.29060490
69MP0006072_abnormal_retinal_apoptosis1.29018619
70MP0000762_abnormal_tongue_morphology1.28035402
71MP0003878_abnormal_ear_physiology1.24876758
72MP0005377_hearing/vestibular/ear_phenot1.24876758
73MP0001765_abnormal_ion_homeostasis1.23860477
74MP0004264_abnormal_extraembryonic_tissu1.23611127
75MP0003633_abnormal_nervous_system1.23174114
76MP0002160_abnormal_reproductive_system1.22780791
77MP0005360_urolithiasis1.21954398
78MP0001216_abnormal_epidermal_layer1.20998969
79MP0005248_abnormal_Harderian_gland1.20761982
80MP0001664_abnormal_digestion1.20347555
81MP0005365_abnormal_bile_salt1.20200702
82MP0005636_abnormal_mineral_homeostasis1.19273037
83MP0002796_impaired_skin_barrier1.17849074
84MP0004133_heterotaxia1.17811672
85MP0002066_abnormal_motor_capabilities/c1.16327140
86MP0005167_abnormal_blood-brain_barrier1.15989846
87MP0001502_abnormal_circadian_rhythm1.15980241
88MP0000778_abnormal_nervous_system1.14476703
89MP0003787_abnormal_imprinting1.13555606
90MP0008872_abnormal_physiological_respon1.12869246
91MP0010771_integument_phenotype1.12113425
92MP0000955_abnormal_spinal_cord1.10851944
93MP0003718_maternal_effect1.10256216
94MP0002139_abnormal_hepatobiliary_system1.09647321
95MP0002653_abnormal_ependyma_morphology1.07820860
96MP0000462_abnormal_digestive_system1.07158741
97MP0000537_abnormal_urethra_morphology1.06499463
98MP0004484_altered_response_of1.05660195
99MP0000427_abnormal_hair_cycle1.05229741
100MP0000377_abnormal_hair_follicle1.03802984
101MP0005646_abnormal_pituitary_gland0.98959544
102MP0003631_nervous_system_phenotype0.97857694
103MP0004742_abnormal_vestibular_system0.96839455
104MP0000627_abnormal_mammary_gland0.93984218
105MP0006276_abnormal_autonomic_nervous0.92519297
106MP0005395_other_phenotype0.91990674
107MP0008004_abnormal_stomach_pH0.91848647
108MP0002090_abnormal_vision0.90758964
109MP0000604_amyloidosis0.90457312
110MP0001963_abnormal_hearing_physiology0.90332700
111MP0003075_altered_response_to0.89290744
112MP0003698_abnormal_male_reproductive0.88377624
113MP0003890_abnormal_embryonic-extraembry0.87053687
114MP0001177_atelectasis0.85200066
115MP0001849_ear_inflammation0.83853942
116MP0005394_taste/olfaction_phenotype0.83579563
117MP0005499_abnormal_olfactory_system0.83579563
118MP0002752_abnormal_somatic_nervous0.82413507
119MP0002234_abnormal_pharynx_morphology0.82129513
120MP0002876_abnormal_thyroid_physiology0.81345526
121MP0002152_abnormal_brain_morphology0.81322871
122MP0009643_abnormal_urine_homeostasis0.80920887
123MP0005310_abnormal_salivary_gland0.80706554
124MP0000013_abnormal_adipose_tissue0.80518258
125MP0008961_abnormal_basal_metabolism0.79288800
126MP0002249_abnormal_larynx_morphology0.79262082
127MP0000569_abnormal_digit_pigmentation0.76136730
128MP0005535_abnormal_body_temperature0.76091764
129MP0001485_abnormal_pinna_reflex0.76018725
130MP0002069_abnormal_eating/drinking_beha0.75914786
131MP0000538_abnormal_urinary_bladder0.74211548
132MP0002168_other_aberrant_phenotype0.72912740
133MP0004145_abnormal_muscle_electrophysio0.72376860
134MP0008874_decreased_physiological_sensi0.71064214
135MP0001881_abnormal_mammary_gland0.70942051
136MP0002233_abnormal_nose_morphology0.70851421
137MP0001188_hyperpigmentation0.70109433
138MP0005195_abnormal_posterior_eye0.70091162
139MP0004142_abnormal_muscle_tone0.68569964
140MP0003866_abnormal_defecation0.65904328
141MP0001756_abnormal_urination0.65752541
142MP0002060_abnormal_skin_morphology0.65367241
143MP0002282_abnormal_trachea_morphology0.65312060
144MP0003646_muscle_fatigue0.64298574
145MP0003566_abnormal_cell_adhesion0.64090446
146MP0000477_abnormal_intestine_morphology0.64048740
147MP0004215_abnormal_myocardial_fiber0.63767991
148MP0003634_abnormal_glial_cell0.63601376
149MP0004019_abnormal_vitamin_homeostasis0.63574572
150MP0005165_increased_susceptibility_to0.63570188
151MP0010030_abnormal_orbit_morphology0.63294536
152MP0003632_abnormal_nervous_system0.63074089
153MP0005166_decreased_susceptibility_to0.63009838
154MP0003123_paternal_imprinting0.60487206
155MP0002896_abnormal_bone_mineralization0.58790323
156MP0001905_abnormal_dopamine_level0.58717190
157MP0000681_abnormal_thyroid_gland0.58425324
158MP0002136_abnormal_kidney_physiology0.57620765
159MP0001727_abnormal_embryo_implantation0.56157736
160MP0003868_abnormal_feces_composition0.51962466
161MP0010155_abnormal_intestine_physiology0.49756587
162MP0009703_decreased_birth_body0.49372217
163MP0000490_abnormal_crypts_of0.49121787
164MP0005408_hypopigmentation0.48886784

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.61208344
2Bronchiectasis (HP:0002110)6.34472812
3Nasal polyposis (HP:0100582)5.54316608
4Myokymia (HP:0002411)5.24663336
5Focal seizures (HP:0007359)4.70566476
6Visual hallucinations (HP:0002367)4.70211453
7Abnormality of the nasal mucosa (HP:0000433)4.46894573
8Atonic seizures (HP:0010819)4.44973476
9Epileptic encephalopathy (HP:0200134)4.18621687
10Febrile seizures (HP:0002373)4.10393530
11Progressive cerebellar ataxia (HP:0002073)4.08969620
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.91247619
13Action tremor (HP:0002345)3.74389336
14Bronchitis (HP:0012387)3.72579399
15Abnormality of macular pigmentation (HP:0008002)3.71123281
16Absence seizures (HP:0002121)3.70206324
17Congenital stationary night blindness (HP:0007642)3.69615119
18Bony spicule pigmentary retinopathy (HP:0007737)3.61725280
19Central scotoma (HP:0000603)3.57658229
20Dynein arm defect of respiratory motile cilia (HP:0012255)3.47704910
21Absent/shortened dynein arms (HP:0200106)3.47704910
22Supranuclear gaze palsy (HP:0000605)3.41873383
23Ventricular fibrillation (HP:0001663)3.38412535
24Abnormal respiratory motile cilium physiology (HP:0012261)3.35009414
25Dialeptic seizures (HP:0011146)3.26525272
26Gaze-evoked nystagmus (HP:0000640)3.19095928
27Recurrent sinusitis (HP:0011108)3.18204061
28Recurrent otitis media (HP:0000403)3.17652066
29Choroideremia (HP:0001139)3.12794344
30Generalized tonic-clonic seizures (HP:0002069)3.08229031
31Chronic sinusitis (HP:0011109)3.02921777
32Broad-based gait (HP:0002136)2.98051852
33Dysdiadochokinesis (HP:0002075)2.97544471
34Hyperventilation (HP:0002883)2.97003418
35Abnormal ciliary motility (HP:0012262)2.93708798
36Dyschromatopsia (HP:0007641)2.86132042
37Dysmetria (HP:0001310)2.67391374
38Occipital encephalocele (HP:0002085)2.65376185
39Rhinitis (HP:0012384)2.63847457
40Cerebral inclusion bodies (HP:0100314)2.63054716
41Dysmetric saccades (HP:0000641)2.62734592
42Postural instability (HP:0002172)2.61598965
43Abnormality of the lower motor neuron (HP:0002366)2.60977856
44Truncal ataxia (HP:0002078)2.59242500
45Scotoma (HP:0000575)2.58155903
46Mutism (HP:0002300)2.57610778
47Genetic anticipation (HP:0003743)2.57352182
48Impaired smooth pursuit (HP:0007772)2.57071485
49Neurofibrillary tangles (HP:0002185)2.56632126
50Pili torti (HP:0003777)2.55667944
51Chronic bronchitis (HP:0004469)2.53130651
52Intention tremor (HP:0002080)2.47468857
53Hyperaldosteronism (HP:0000859)2.45258428
54Pigmentary retinal degeneration (HP:0001146)2.43749423
55Abnormal respiratory motile cilium morphology (HP:0005938)2.43160462
56Abnormal respiratory epithelium morphology (HP:0012253)2.43160462
57Abnormal rod and cone electroretinograms (HP:0008323)2.41888378
58Depression (HP:0000716)2.41760104
59Hemiparesis (HP:0001269)2.39830207
60Renal salt wasting (HP:0000127)2.39194446
61Syncope (HP:0001279)2.39001194
62Hyperactive renin-angiotensin system (HP:0000841)2.37721471
63Abnormal eating behavior (HP:0100738)2.35528260
64Abnormality of renin-angiotensin system (HP:0000847)2.35428477
65Urinary bladder sphincter dysfunction (HP:0002839)2.34057826
66Lip pit (HP:0100267)2.33964706
67Amblyopia (HP:0000646)2.32528184
68Abnormality of ocular smooth pursuit (HP:0000617)2.30560062
69Bundle branch block (HP:0011710)2.29113776
70Metabolic alkalosis (HP:0200114)2.25676946
71Taurodontia (HP:0000679)2.25372822
72Abnormality of permanent molar morphology (HP:0011071)2.25372822
73Abnormality of the dental root (HP:0006486)2.25372822
74Ankle clonus (HP:0011448)2.25365459
75True hermaphroditism (HP:0010459)2.24824015
76Infertility (HP:0000789)2.22456201
77Diplopia (HP:0000651)2.22422612
78Abnormality of binocular vision (HP:0011514)2.22422612
79Impaired vibration sensation in the lower limbs (HP:0002166)2.22304519
80Pancreatic fibrosis (HP:0100732)2.20619604
81Impaired social interactions (HP:0000735)2.19872863
82Abnormal social behavior (HP:0012433)2.19872863
83Atelectasis (HP:0100750)2.16459096
84Poor eye contact (HP:0000817)2.16006313
85Chronic otitis media (HP:0000389)2.14163004
86Termporal pattern (HP:0011008)2.12814354
87Insidious onset (HP:0003587)2.12814354
88Anxiety (HP:0000739)2.09916768
89Absent speech (HP:0001344)2.03795882
90Cystic liver disease (HP:0006706)2.03413236
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01949118
92Abnormality of molar morphology (HP:0011070)2.01230568
93Abnormality of molar (HP:0011077)2.01230568
94Excessive salivation (HP:0003781)2.01167899
95Drooling (HP:0002307)2.01167899
96Bradykinesia (HP:0002067)2.00209531
97Hemiplegia (HP:0002301)1.97936830
98Status epilepticus (HP:0002133)1.96614491
99Onycholysis (HP:0001806)1.95611040
100Male infertility (HP:0003251)1.95002391
101Abnormality of the dental pulp (HP:0006479)1.94580387
102Hyperkalemia (HP:0002153)1.93550972
103Decreased central vision (HP:0007663)1.91665975
104Neuronal loss in central nervous system (HP:0002529)1.88282292
105Tubulointerstitial nephritis (HP:0001970)1.87493202
106Type II diabetes mellitus (HP:0005978)1.86418349
107Gait imbalance (HP:0002141)1.85680364
108Right ventricular cardiomyopathy (HP:0011663)1.85614496
109Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85045367
110Urinary urgency (HP:0000012)1.83929781
111Abnormality of monocarboxylic acid metabolism (HP:0010996)1.82907005
112Flat acetabular roof (HP:0003180)1.82372309
113Abnormality of chloride homeostasis (HP:0011422)1.82197520
114Progressive inability to walk (HP:0002505)1.80903297
115Attenuation of retinal blood vessels (HP:0007843)1.80418071
116Papilledema (HP:0001085)1.79735342
117Scanning speech (HP:0002168)1.79718050
118Abnormality of the distal phalanges of the toes (HP:0010182)1.79405976
119Photophobia (HP:0000613)1.79033347
120Gait ataxia (HP:0002066)1.78117976
121Abnormality of nail color (HP:0100643)1.78083818
122Rapidly progressive (HP:0003678)1.76605883
123Abnormality of the corticospinal tract (HP:0002492)1.76215657
124Stereotypic behavior (HP:0000733)1.75487077
125Impaired vibratory sensation (HP:0002495)1.75292135
126Abnormality of midbrain morphology (HP:0002418)1.74205344
127Molar tooth sign on MRI (HP:0002419)1.74205344
128Malnutrition (HP:0004395)1.73420976
129Popliteal pterygium (HP:0009756)1.72569182
130Abnormality of saccadic eye movements (HP:0000570)1.72370815
131Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71778649
132Hyponatremia (HP:0002902)1.71648853
133Retinitis pigmentosa (HP:0000510)1.70179441
134Bifid scrotum (HP:0000048)1.69869223
135Plantar hyperkeratosis (HP:0007556)1.69868629
136Medial flaring of the eyebrow (HP:0010747)1.69490477
137Abnormal hair laboratory examination (HP:0003328)1.68407294
138Vascular calcification (HP:0004934)1.67839706
139Congenital primary aphakia (HP:0007707)1.67807658
140Decreased circulating renin level (HP:0003351)1.67795632
141Abnormality of the salivary glands (HP:0010286)1.66954950
142Hypoplastic labia majora (HP:0000059)1.66701206
143Pancreatic cysts (HP:0001737)1.64930756
144Furrowed tongue (HP:0000221)1.64500352
145Postaxial foot polydactyly (HP:0001830)1.59448679
146Nephronophthisis (HP:0000090)1.58600048
147Hyperphosphatemia (HP:0002905)1.56908258
148Male pseudohermaphroditism (HP:0000037)1.56214344
149Spinal cord compression (HP:0002176)1.53703464
150Fragile nails (HP:0001808)1.53018040
151Hypoplasia of dental enamel (HP:0006297)1.52058254
152Chronic hepatic failure (HP:0100626)1.51107668
153Abnormality of glutamine family amino acid metabolism (HP:0010902)1.48442145
154Fat malabsorption (HP:0002630)1.47739862
155Absent frontal sinuses (HP:0002688)1.46341834
156Cone-rod dystrophy (HP:0000548)1.46116797
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.44235897
158Abnormality of the labia majora (HP:0012881)1.42986414
159Bell-shaped thorax (HP:0001591)1.41656964
160Abnormality of sodium homeostasis (HP:0010931)1.38924090
161Median cleft lip (HP:0000161)1.37159815
162Milia (HP:0001056)1.36996753
163Palmoplantar hyperkeratosis (HP:0000972)1.36783980
164Short nail (HP:0001799)1.36724373
165Adrenal overactivity (HP:0002717)1.36621073
166Hand muscle atrophy (HP:0009130)1.32589313
167Cardiovascular calcification (HP:0011915)1.31240072
168Tubular atrophy (HP:0000092)1.29386747
169Abnormality of the renal medulla (HP:0100957)1.28746347
170Alopecia of scalp (HP:0002293)1.28687806
171Hypokalemic alkalosis (HP:0001949)1.27990633
172Dehydration (HP:0001944)1.26820506
173Sparse eyelashes (HP:0000653)1.26054427
174Abnormality of vitamin metabolism (HP:0100508)1.25919752
175Labial hypoplasia (HP:0000066)1.25534640
176Intrahepatic cholestasis (HP:0001406)1.25526889
177Palmar hyperkeratosis (HP:0010765)1.24575944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.48154871
2MAPK155.93711370
3EPHA43.78688186
4NTRK33.67407085
5MAP3K93.40551887
6RIPK43.31173773
7STK242.91423120
8MAP3K42.78569721
9PRKD32.48888447
10LMTK22.30426002
11DAPK22.27698106
12MINK12.17358175
13MAP2K72.12112696
14KSR22.08517331
15STK382.02416947
16MAP3K22.02059250
17MAP3K121.95672347
18MET1.87678368
19SMG11.83080249
20PAK61.82672460
21MAP2K41.80945296
22MAPKAPK31.74340851
23CAMKK11.74195976
24RIPK11.72182959
25NEK61.71599504
26PDK31.53012759
27PDK41.53012759
28CASK1.48485006
29GRK51.44950874
30BMPR21.43285306
31PLK21.40987138
32NTRK11.39357370
33EEF2K1.36633105
34PTK2B1.35589332
35DAPK11.35205841
36PBK1.33125121
37BCR1.32935940
38LATS11.32247897
39PAK41.32096487
40OXSR11.32036433
41PNCK1.31294716
42ACVR1B1.30237428
43MARK11.28501959
44FRK1.27845805
45CDK51.26682887
46PRKCI1.22707634
47PDK21.22692086
48CDK191.21890790
49WNK11.21832329
50NTRK21.16270500
51TYRO31.14405562
52WNK41.14025563
53TAOK11.13702800
54CAMKK21.12683865
55ARAF1.09952791
56TRIB31.08890498
57KSR11.08628240
58PRKCG1.04223530
59STK391.03384516
60AKT31.00233410
61STK110.99865157
62TSSK60.99505292
63CAMK2B0.98352560
64NME10.97731459
65MAP3K30.96953300
66CAMK2A0.96405549
67PINK10.94225811
68FER0.93226978
69RPS6KB20.90678991
70PTK20.90087079
71PDPK10.88500368
72PDK10.86747420
73SIK20.85628717
74GRK10.84658146
75LRRK20.82313493
76TESK10.81147777
77CAMK2D0.81064144
78BRSK20.80407117
79PTK60.79784556
80SCYL20.77846014
81PRKG20.76575233
82RET0.74045151
83SGK4940.73698181
84SGK2230.73698181
85CAMK2G0.71194779
86SGK30.70630088
87MST1R0.69297225
88SGK10.67318467
89MAP3K10.67273188
90ERBB20.65607382
91SGK20.65356648
92MYLK0.65310881
93EIF2AK10.63415023
94CAMK10.63271066
95PIK3CA0.62784083
96ICK0.61584978
97LATS20.61076311
98CDC42BPA0.60582389
99MAP3K130.60158932
100MAP3K60.59431112
101FES0.58809286
102PAK30.56861304
103CDK150.55941154
104CDK180.54920514
105FGR0.54784241
106MST40.54437017
107DMPK0.53206962
108RAF10.51124264
109MAP2K10.51083807
110PRKCH0.50872749
111CDK140.48160074
112TRIM280.47544650
113PHKG20.47118395
114PHKG10.47118395
115CCNB10.46941932
116PRKCZ0.46178855
117CDK11A0.46009305
118DDR20.45746139
119STK30.45678573
120ILK0.45185546
121CAMK1G0.44322128
122MAPKAPK50.44027488
123CSNK1E0.43690352
124PRKCE0.43659049
125MAPK130.42116199
126STK38L0.41715025
127SIK10.41544270
128GRK60.40780750
129WNK30.40723842
130AKT20.40117477
131FYN0.39594105
132RPS6KA30.39453579
133PRKCA0.39231378
134AURKA0.37119624
135ROCK20.36744250
136RPS6KB10.36440149
137PKN20.32052763
138MARK20.31646632
139ERBB30.31440989
140BRAF0.30966941
141CSNK1A10.27561864
142CSNK1G20.26479307
143BRSK10.26445989
144PRKCD0.25785946
145MAP2K20.21693029
146SRC0.20013421
147YES10.19965599
148MELK0.19576237
149STK160.17946551
150LIMK10.17871507
151PRKAA20.16844572
152RPS6KA20.15245131
153CSNK1G10.14964147

Predicted pathways (KEGG)

RankGene SetZ-score
1Histidine metabolism_Homo sapiens_hsa003403.64429395
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.59061075
3Phototransduction_Homo sapiens_hsa047443.54299692
4Phenylalanine metabolism_Homo sapiens_hsa003603.51800533
5Nicotine addiction_Homo sapiens_hsa050333.04234151
6Chemical carcinogenesis_Homo sapiens_hsa052042.96493869
7Synaptic vesicle cycle_Homo sapiens_hsa047212.91951820
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.89593969
9Olfactory transduction_Homo sapiens_hsa047402.84737702
10Long-term potentiation_Homo sapiens_hsa047202.53916701
11Tyrosine metabolism_Homo sapiens_hsa003502.38940609
12Salivary secretion_Homo sapiens_hsa049702.31170610
13Circadian entrainment_Homo sapiens_hsa047132.29803465
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.29115576
15Amphetamine addiction_Homo sapiens_hsa050312.28343794
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27926290
17Glutamatergic synapse_Homo sapiens_hsa047242.22999545
18Vitamin digestion and absorption_Homo sapiens_hsa049772.07745386
19Gastric acid secretion_Homo sapiens_hsa049712.06210439
20Caffeine metabolism_Homo sapiens_hsa002322.04837267
21GABAergic synapse_Homo sapiens_hsa047272.04388696
22Retinol metabolism_Homo sapiens_hsa008301.96340327
23Insulin secretion_Homo sapiens_hsa049111.92770550
24Morphine addiction_Homo sapiens_hsa050321.91773262
25beta-Alanine metabolism_Homo sapiens_hsa004101.91160719
26Dopaminergic synapse_Homo sapiens_hsa047281.85415686
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84021391
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.82709347
29Glutathione metabolism_Homo sapiens_hsa004801.82656000
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.73756282
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.71785817
32Renin secretion_Homo sapiens_hsa049241.69638666
33Taste transduction_Homo sapiens_hsa047421.69528818
34Mineral absorption_Homo sapiens_hsa049781.68726837
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66139111
36Collecting duct acid secretion_Homo sapiens_hsa049661.65973620
37Huntingtons disease_Homo sapiens_hsa050161.61155002
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60863692
39Cholinergic synapse_Homo sapiens_hsa047251.52172802
40Long-term depression_Homo sapiens_hsa047301.50685431
41Oxytocin signaling pathway_Homo sapiens_hsa049211.41203420
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.39364023
43Calcium signaling pathway_Homo sapiens_hsa040201.38008674
44GnRH signaling pathway_Homo sapiens_hsa049121.36264681
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35383318
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.33572626
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33399674
48Starch and sucrose metabolism_Homo sapiens_hsa005001.32418329
49* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32235080
50Serotonergic synapse_Homo sapiens_hsa047261.30111724
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22037325
52Cocaine addiction_Homo sapiens_hsa050301.20850667
53Arginine biosynthesis_Homo sapiens_hsa002201.19555607
54Pancreatic secretion_Homo sapiens_hsa049721.18513841
55cAMP signaling pathway_Homo sapiens_hsa040241.17720536
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14869099
57Arginine and proline metabolism_Homo sapiens_hsa003301.14385837
58Fatty acid degradation_Homo sapiens_hsa000711.14313755
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11487054
60Estrogen signaling pathway_Homo sapiens_hsa049151.11255293
61Linoleic acid metabolism_Homo sapiens_hsa005911.10639483
62Thyroid hormone synthesis_Homo sapiens_hsa049181.09944788
63Type II diabetes mellitus_Homo sapiens_hsa049301.07913402
64Drug metabolism - other enzymes_Homo sapiens_hsa009831.06988944
65Vibrio cholerae infection_Homo sapiens_hsa051101.06652971
66Bile secretion_Homo sapiens_hsa049761.01555054
67Gap junction_Homo sapiens_hsa045401.01543058
68Vitamin B6 metabolism_Homo sapiens_hsa007500.97929924
69Dorso-ventral axis formation_Homo sapiens_hsa043200.97361475
70Cardiac muscle contraction_Homo sapiens_hsa042600.91982122
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89918006
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.89486148
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88480067
74Melanogenesis_Homo sapiens_hsa049160.82947118
75Inositol phosphate metabolism_Homo sapiens_hsa005620.82275091
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82042940
77Folate biosynthesis_Homo sapiens_hsa007900.81299533
78Adherens junction_Homo sapiens_hsa045200.80755330
79Glioma_Homo sapiens_hsa052140.80447970
80PPAR signaling pathway_Homo sapiens_hsa033200.75709903
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75080399
82Choline metabolism in cancer_Homo sapiens_hsa052310.73429168
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73189378
84VEGF signaling pathway_Homo sapiens_hsa043700.73039751
85Pyruvate metabolism_Homo sapiens_hsa006200.72807721
86Oocyte meiosis_Homo sapiens_hsa041140.69738293
87ErbB signaling pathway_Homo sapiens_hsa040120.66370385
88Axon guidance_Homo sapiens_hsa043600.66367767
89Glucagon signaling pathway_Homo sapiens_hsa049220.65653662
90ABC transporters_Homo sapiens_hsa020100.64465641
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63854140
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.61230637
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60749497
94Fat digestion and absorption_Homo sapiens_hsa049750.58611112
95Arachidonic acid metabolism_Homo sapiens_hsa005900.58484676
96Circadian rhythm_Homo sapiens_hsa047100.57435463
97Peroxisome_Homo sapiens_hsa041460.56980857
98Thyroid cancer_Homo sapiens_hsa052160.56520618
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54777795
100* Glycerophospholipid metabolism_Homo sapiens_hsa005640.53648954
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52756503
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52713754
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52437742
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51299549
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50601506
106Hippo signaling pathway_Homo sapiens_hsa043900.50363573
107Glycerolipid metabolism_Homo sapiens_hsa005610.50049543
108Fructose and mannose metabolism_Homo sapiens_hsa000510.49727452
109Alzheimers disease_Homo sapiens_hsa050100.48248506
110Protein digestion and absorption_Homo sapiens_hsa049740.47139070
111Tight junction_Homo sapiens_hsa045300.46380857
112MAPK signaling pathway_Homo sapiens_hsa040100.45465143
113Renin-angiotensin system_Homo sapiens_hsa046140.44419065
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44224296
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.44009404
116Pentose phosphate pathway_Homo sapiens_hsa000300.43656382
117Sulfur metabolism_Homo sapiens_hsa009200.43623017
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.43120328
119Galactose metabolism_Homo sapiens_hsa000520.43035257
120African trypanosomiasis_Homo sapiens_hsa051430.43021904
121Nitrogen metabolism_Homo sapiens_hsa009100.42086316
122* Metabolic pathways_Homo sapiens_hsa011000.41746262
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41461861
124Endocytosis_Homo sapiens_hsa041440.39495179
125Fatty acid elongation_Homo sapiens_hsa000620.39215368
126Dilated cardiomyopathy_Homo sapiens_hsa054140.38810841
127Ras signaling pathway_Homo sapiens_hsa040140.38315776
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36907156
129Sphingolipid metabolism_Homo sapiens_hsa006000.36633336
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35657306
131Rap1 signaling pathway_Homo sapiens_hsa040150.35301523
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34611674
133mTOR signaling pathway_Homo sapiens_hsa041500.34385840
134Ovarian steroidogenesis_Homo sapiens_hsa049130.33759204
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33605863
136Tryptophan metabolism_Homo sapiens_hsa003800.33190658
137Fatty acid biosynthesis_Homo sapiens_hsa000610.32187255
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30009320
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.29878441
140Fatty acid metabolism_Homo sapiens_hsa012120.29696979
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.29433405
142Salmonella infection_Homo sapiens_hsa051320.27822931
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25994205
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23627835
145Oxidative phosphorylation_Homo sapiens_hsa001900.22962539

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