CDSN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)9.46650189
2multicellular organismal water homeostasis (GO:0050891)8.75358963
3intermediate filament organization (GO:0045109)8.69029967
4hemidesmosome assembly (GO:0031581)8.03245315
5* keratinocyte differentiation (GO:0030216)7.89885051
6water homeostasis (GO:0030104)7.26188367
7bundle of His cell to Purkinje myocyte communication (GO:0086069)6.95254702
8* epidermal cell differentiation (GO:0009913)6.37732137
9* epidermis development (GO:0008544)6.34177732
10regulation of natural killer cell differentiation (GO:0032823)5.44556829
11ectoderm development (GO:0007398)5.37190880
12intermediate filament cytoskeleton organization (GO:0045104)5.36446283
13adhesion of symbiont to host cell (GO:0044650)5.29541976
14virion attachment to host cell (GO:0019062)5.29541976
15intermediate filament-based process (GO:0045103)5.22404418
16negative regulation of interferon-gamma production (GO:0032689)4.82587362
17gap junction assembly (GO:0016264)4.69766674
18long-chain fatty acid biosynthetic process (GO:0042759)4.63037780
19keratinocyte proliferation (GO:0043616)4.58882120
20fatty acid elongation (GO:0030497)4.39178887
21adhesion of symbiont to host (GO:0044406)4.38739142
22atrioventricular valve morphogenesis (GO:0003181)4.06616892
23lateral sprouting from an epithelium (GO:0060601)3.85351842
24phosphatidylserine metabolic process (GO:0006658)3.82398188
25hair follicle morphogenesis (GO:0031069)3.81767993
26ceramide biosynthetic process (GO:0046513)3.79773996
27keratinocyte development (GO:0003334)3.74528409
28negative regulation of cell fate specification (GO:0009996)3.72215323
29skin development (GO:0043588)3.71170154
30detection of external biotic stimulus (GO:0098581)3.71085508
31regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.67830389
32regulation of ruffle assembly (GO:1900027)3.60119332
33negative regulation of interleukin-17 production (GO:0032700)3.57324368
34linoleic acid metabolic process (GO:0043651)3.54123081
35polarized epithelial cell differentiation (GO:0030859)3.52332417
36regulation of T cell chemotaxis (GO:0010819)3.51291770
37positive regulation of T cell chemotaxis (GO:0010820)3.51291770
38cell wall macromolecule catabolic process (GO:0016998)3.48749463
39cell wall macromolecule metabolic process (GO:0044036)3.48749463
40phosphatidylinositol acyl-chain remodeling (GO:0036149)3.42473341
41glucosamine-containing compound catabolic process (GO:1901072)3.35881920
42epithelial cell differentiation involved in prostate gland development (GO:0060742)3.34344382
43long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.28500055
44sequestering of metal ion (GO:0051238)3.27121223
45negative regulation of keratinocyte proliferation (GO:0010839)3.24992300
46phospholipid catabolic process (GO:0009395)3.23036539
47planar cell polarity pathway involved in neural tube closure (GO:0090179)3.18801541
48detection of biotic stimulus (GO:0009595)3.16582995
49cell-substrate junction assembly (GO:0007044)3.13512078
50phosphatidylserine acyl-chain remodeling (GO:0036150)3.12568720
51epithelial cell-cell adhesion (GO:0090136)3.12438324
52phospholipid efflux (GO:0033700)3.11532007
53alditol phosphate metabolic process (GO:0052646)3.10063072
54* epithelium development (GO:0060429)3.04169969
55hair cycle process (GO:0022405)3.03686884
56molting cycle process (GO:0022404)3.03686884
57citrulline biosynthetic process (GO:0019240)2.95422754
58defense response to fungus (GO:0050832)2.94887346
59regulation of cardioblast differentiation (GO:0051890)2.93669056
60regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.92347879
61sphingoid metabolic process (GO:0046519)2.86097364
62lipoxygenase pathway (GO:0019372)2.86005410
63ventricular cardiac muscle cell action potential (GO:0086005)2.84672093
64regulation of monocyte chemotaxis (GO:0090025)2.79559588
65long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.78039118
66positive regulation of keratinocyte differentiation (GO:0045618)2.76443039
67negative regulation of stress fiber assembly (GO:0051497)2.74927503
68detection of bacterium (GO:0016045)2.73669417
69regulation of keratinocyte proliferation (GO:0010837)2.73022155
70fatty-acyl-CoA metabolic process (GO:0035337)2.72613122
71sphingosine metabolic process (GO:0006670)2.70326532
72positive regulation of epidermis development (GO:0045684)2.67567276
73phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.67067264
74negative regulation of cell fate commitment (GO:0010454)2.66695863
75phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.66245686
76cell communication involved in cardiac conduction (GO:0086065)2.66197541
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.66087429
78surfactant homeostasis (GO:0043129)2.66020129
79sphingolipid biosynthetic process (GO:0030148)2.61850998
80protein heterotrimerization (GO:0070208)2.61737622
81regulation of natural killer cell activation (GO:0032814)2.61676467
82fatty-acyl-CoA biosynthetic process (GO:0046949)2.59769909
83regulation of transforming growth factor beta1 production (GO:0032908)2.57502697
84fibrinolysis (GO:0042730)2.55544931
85regulation of protein localization to cell surface (GO:2000008)2.55359262
86positive regulation of cholesterol efflux (GO:0010875)2.53257038
87G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.50744919
88positive regulation of monocyte chemotaxis (GO:0090026)2.48985980
89regulation of epidermal cell differentiation (GO:0045604)2.47369241
90lymph vessel development (GO:0001945)2.47350059
91establishment of tissue polarity (GO:0007164)2.47075178
92establishment of planar polarity (GO:0001736)2.47075178
93chemical homeostasis within a tissue (GO:0048875)2.45468534
94phosphatidylglycerol metabolic process (GO:0046471)2.45039601
95regulation of phospholipase A2 activity (GO:0032429)2.44742996
96non-canonical Wnt signaling pathway (GO:0035567)2.44718613
97* epithelial cell differentiation (GO:0030855)2.44285463
98hair follicle development (GO:0001942)2.43915064
99defense response to Gram-negative bacterium (GO:0050829)2.43883042
100phospholipid scrambling (GO:0017121)2.40770558
101positive regulation of glomerulus development (GO:0090193)2.39518888
102diol metabolic process (GO:0034311)2.38125974
103regulation of axon regeneration (GO:0048679)2.37749379
104regulation of neuron projection regeneration (GO:0070570)2.37749379
105regulation of cell fate specification (GO:0042659)2.36355704
106positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.35274480
107intestinal epithelial cell development (GO:0060576)2.35156139
108unsaturated fatty acid biosynthetic process (GO:0006636)2.33563887
109regulation of hair cycle (GO:0042634)2.32334022
110detection of other organism (GO:0098543)2.32276641
111heart valve morphogenesis (GO:0003179)2.31798526
112positive regulation of cholesterol transport (GO:0032376)2.28995407
113positive regulation of sterol transport (GO:0032373)2.28995407
114positive regulation of hair follicle development (GO:0051798)2.28665464
115positive regulation of hair cycle (GO:0042635)2.28665464
116eyelid development in camera-type eye (GO:0061029)2.28290842
117cell surface receptor signaling pathway involved in heart development (GO:0061311)2.28073616
118regulation of heart rate by cardiac conduction (GO:0086091)2.25931740
119tooth mineralization (GO:0034505)2.25612563
120response to UV-B (GO:0010224)2.25285202
121regulation of hair follicle development (GO:0051797)2.24506823
122regulation of keratinocyte differentiation (GO:0045616)2.24260452
123positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.24035774
124phosphatidylcholine acyl-chain remodeling (GO:0036151)2.24011911
125one-carbon compound transport (GO:0019755)2.22542070
126regulation of epidermis development (GO:0045682)2.21890228
127* skin morphogenesis (GO:0043589)2.21845498
128plasma membrane repair (GO:0001778)2.20375735
129positive regulation of epidermal cell differentiation (GO:0045606)2.20023848
130cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.16553413
131epithelial cell proliferation (GO:0050673)2.15198789
132regulation of cholesterol homeostasis (GO:2000188)2.13931711
133positive regulation of cellular amide metabolic process (GO:0034250)2.11041970
134cardiac conduction (GO:0061337)2.10952408
135phosphatidic acid biosynthetic process (GO:0006654)2.07458654
136keratinization (GO:0031424)18.6789252
137hair cycle (GO:0042633)17.6769935
138molting cycle (GO:0042303)17.6769935
139establishment of skin barrier (GO:0061436)15.0728960
140desmosome organization (GO:0002934)14.4764638
141regulation of water loss via skin (GO:0033561)13.1756509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.60942694
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.35678338
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.55028113
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.40614605
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.37076337
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.23962493
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16921514
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.11851771
9ZNF263_19887448_ChIP-Seq_K562_Human2.09782432
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.05851935
11SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.00304307
12SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.00304307
13TP63_17297297_ChIP-ChIP_HaCaT_Human14.6800566
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.93791202
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91514142
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.89590910
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89285791
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86228829
19FOXO3_23340844_ChIP-Seq_DLD1_Human1.83767868
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46010976
21* ATF3_27146783_Chip-Seq_COLON_Human1.44539313
22RACK7_27058665_Chip-Seq_MCF-7_Human1.43087905
23TP63_23658742_ChIP-Seq_EP156T_Human1.42061263
24TP63_22573176_ChIP-Seq_HFKS_Human1.40537442
25SOX2_20726797_ChIP-Seq_SW620_Human1.31988310
26CTCF_20526341_ChIP-Seq_ESCs_Human1.29163392
27CJUN_26792858_Chip-Seq_BT549_Human1.28883662
28AR_21572438_ChIP-Seq_LNCaP_Human1.28305434
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27650090
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.27317997
31BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.27040787
32RUNX1_27514584_Chip-Seq_MCF-7_Human1.25687256
33RXR_22108803_ChIP-Seq_LS180_Human1.25071887
34KLF5_25053715_ChIP-Seq_YYC3_Human1.25028618
35GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.24051921
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22460521
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22352565
38CTCF_27219007_Chip-Seq_Bcells_Human1.20790638
39TCF4_18268006_ChIP-ChIP_LS174T_Human1.20620422
40GATA3_24758297_ChIP-Seq_MCF-7_Human1.19897789
41P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.19466370
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19018752
43LXR_22292898_ChIP-Seq_THP-1_Human1.17400335
44* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17010492
45TP53_18474530_ChIP-ChIP_U2OS_Human1.16782106
46TP53_20018659_ChIP-ChIP_R1E_Mouse1.16093683
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15785501
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12112603
49* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11838902
50CLOCK_20551151_ChIP-Seq_293T_Human1.11117593
51E2F1_20622854_ChIP-Seq_HELA_Human1.08963200
52* UBF1/2_26484160_Chip-Seq_HMECs_Human1.08537662
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08519647
54EGR1_19032775_ChIP-ChIP_M12_Human1.08095872
55CEBPB_22108803_ChIP-Seq_LS180_Human1.07261730
56GATA6_21074721_ChIP-Seq_CACO-2_Human1.07227076
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04269932
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02753493
59ERG_20517297_ChIP-Seq_VCAP_Human1.01080570
60SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99950038
61BCOR_27268052_Chip-Seq_Bcells_Human0.98226718
62SA1_27219007_Chip-Seq_ERYTHROID_Human0.96554973
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95719454
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95297593
65YY1_22570637_ChIP-Seq_MALME-3M_Human0.94542592
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93751646
67* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.92956062
68GATA4_25053715_ChIP-Seq_YYC3_Human0.92154954
69NANOG_20526341_ChIP-Seq_ESCs_Human0.91651005
70* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91110255
71STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90718782
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90587845
73AHR_22903824_ChIP-Seq_MCF-7_Human0.88717626
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88658951
75TAF2_19829295_ChIP-Seq_ESCs_Human0.88471388
76* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88052730
77FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87632224
78P68_20966046_ChIP-Seq_HELA_Human0.87186123
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87078499
80FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86732062
81JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84957059
82P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84062086
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83754173
84MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.83231850
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83165884
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80625009
87PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79081573
88BCL6_27268052_Chip-Seq_Bcells_Human0.78546603
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.77699602
90EZH2_27294783_Chip-Seq_ESCs_Mouse0.77664039
91TP53_16413492_ChIP-PET_HCT116_Human0.76700959
92P53_21459846_ChIP-Seq_SAOS-2_Human0.76558171
93GATA6_25053715_ChIP-Seq_YYC3_Human0.76311630
94SMC4_20622854_ChIP-Seq_HELA_Human0.75947864
95* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75355420
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.73884455
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.73614441
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.73438147
99KDM2B_26808549_Chip-Seq_K562_Human0.72622494
100JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.72322590
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72284648
102EZH2_27304074_Chip-Seq_ESCs_Mouse0.72169002
103TBX20_22080862_ChIP-Seq_HEART_Mouse0.71087043
104TBX20_22328084_ChIP-Seq_HEART_Mouse0.71087043
105RAC3_21632823_ChIP-Seq_H3396_Human0.70560403
106HNFA_21074721_ChIP-Seq_CACO-2_Human0.70262226
107GATA2_19941826_ChIP-Seq_K562_Human0.70058078
108SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.68912860
109PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.68845017
110RBPJ_21746931_ChIP-Seq_IB4_Human0.68181985
111RNF2_27304074_Chip-Seq_ESCs_Mouse0.68103576
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.67886611
113BCAT_22108803_ChIP-Seq_LS180_Human0.67467771
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.67366849
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.67164699
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.66584306
117ELF1_20517297_ChIP-Seq_JURKAT_Human0.66452366
118CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.66200088
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.65744886
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65072241
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65072241
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.65000519
123SMAD4_21741376_ChIP-Seq_ESCs_Human0.64638270
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64178494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002796_impaired_skin_barrier7.93518273
2* MP0005275_abnormal_skin_tensile6.51739324
3MP0010234_abnormal_vibrissa_follicle6.28330688
4MP0000579_abnormal_nail_morphology6.02405797
5* MP0005501_abnormal_skin_physiology4.90504299
6MP0002098_abnormal_vibrissa_morphology3.64408614
7MP0003705_abnormal_hypodermis_morpholog3.57746982
8MP0010678_abnormal_skin_adnexa3.33348064
9* MP0001216_abnormal_epidermal_layer3.20396339
10MP0003941_abnormal_skin_development3.15726292
11MP0000383_abnormal_hair_follicle3.06925679
12* MP0000647_abnormal_sebaceous_gland3.05914880
13* MP0002060_abnormal_skin_morphology3.05124262
14MP0004381_abnormal_hair_follicle3.01186116
15* MP0010771_integument_phenotype2.98914650
16* MP0000377_abnormal_hair_follicle2.64989801
17MP0003453_abnormal_keratinocyte_physiol2.53445554
18MP0004885_abnormal_endolymph2.48911973
19MP0003878_abnormal_ear_physiology2.48397997
20MP0005377_hearing/vestibular/ear_phenot2.48397997
21MP0000427_abnormal_hair_cycle2.46738391
22MP0002254_reproductive_system_inflammat2.40566996
23* MP0004947_skin_inflammation2.39717201
24MP0000467_abnormal_esophagus_morphology2.37567823
25MP0005451_abnormal_body_composition2.26827440
26MP0000762_abnormal_tongue_morphology1.88568317
27MP0008438_abnormal_cutaneous_collagen1.87961821
28MP0004185_abnormal_adipocyte_glucose1.79790215
29MP0003566_abnormal_cell_adhesion1.76687158
30* MP0009931_abnormal_skin_appearance1.69491321
31* MP0000367_abnormal_coat/_hair1.51676892
32MP0003191_abnormal_cellular_cholesterol1.49449729
33* MP0001243_abnormal_dermal_layer1.45518424
34MP0002234_abnormal_pharynx_morphology1.40049912
35* MP0001191_abnormal_skin_condition1.32255684
36MP0001188_hyperpigmentation1.11911768
37MP0001851_eye_inflammation0.98334174
38MP0001346_abnormal_lacrimal_gland0.97542319
39MP0000015_abnormal_ear_pigmentation0.94166820
40MP0005174_abnormal_tail_pigmentation0.86740390
41MP0005666_abnormal_adipose_tissue0.85486290
42MP0005023_abnormal_wound_healing0.83930854
43MP0005409_darkened_coat_color0.83425350
44MP0010030_abnormal_orbit_morphology0.81167505
45MP0009053_abnormal_anal_canal0.79858900
46MP0001340_abnormal_eyelid_morphology0.78322740
47MP0002282_abnormal_trachea_morphology0.71579775
48MP0004272_abnormal_basement_membrane0.71559506
49MP0002249_abnormal_larynx_morphology0.70850844
50MP0005375_adipose_tissue_phenotype0.69121555
51MP0002009_preneoplasia0.69079424
52MP0001849_ear_inflammation0.68916779
53MP0000566_synostosis0.68216580
54MP0003755_abnormal_palate_morphology0.66060408
55* MP0001784_abnormal_fluid_regulation0.64590193
56MP0002877_abnormal_melanocyte_morpholog0.60550859
57MP0008004_abnormal_stomach_pH0.60107320
58MP0005075_abnormal_melanosome_morpholog0.59574322
59MP0000465_gastrointestinal_hemorrhage0.58392062
60MP0005503_abnormal_tendon_morphology0.58084002
61MP0002095_abnormal_skin_pigmentation0.57654902
62MP0010352_gastrointestinal_tract_polyps0.55109702
63MP0005508_abnormal_skeleton_morphology0.53472197
64MP0004782_abnormal_surfactant_physiolog0.53152358
65MP0002177_abnormal_outer_ear0.53015760
66MP0000627_abnormal_mammary_gland0.52548127
67MP0005076_abnormal_cell_differentiation0.51470393
68MP0003950_abnormal_plasma_membrane0.51247059
69MP0002111_abnormal_tail_morphology0.49449993
70MP0000013_abnormal_adipose_tissue0.48703762
71MP0006054_spinal_hemorrhage0.47649643
72MP0009379_abnormal_foot_pigmentation0.47405038
73MP0000678_abnormal_parathyroid_gland0.45330342
74MP0003315_abnormal_perineum_morphology0.44258865
75MP0000751_myopathy0.43592509
76MP0003300_gastrointestinal_ulcer0.43572003
77MP0002909_abnormal_adrenal_gland0.43201510
78MP0009780_abnormal_chondrocyte_physiolo0.41585847
79MP0003385_abnormal_body_wall0.40643558
80MP0009384_cardiac_valve_regurgitation0.40465854
81MP0003638_abnormal_response/metabolism_0.39384740
82MP0005623_abnormal_meninges_morphology0.38906053
83MP0001177_atelectasis0.37367648
84MP0002896_abnormal_bone_mineralization0.36985670
85MP0000750_abnormal_muscle_regeneration0.36944926
86MP0002971_abnormal_brown_adipose0.36261424
87MP0003011_delayed_dark_adaptation0.36202189
88MP0001542_abnormal_bone_strength0.36198082
89MP0002133_abnormal_respiratory_system0.36142802
90MP0005388_respiratory_system_phenotype0.36142802
91MP0005670_abnormal_white_adipose0.35354904
92MP0004264_abnormal_extraembryonic_tissu0.33719298
93MP0003763_abnormal_thymus_physiology0.33676920
94MP0001958_emphysema0.33443336
95MP0002166_altered_tumor_susceptibility0.32701785
96MP0008260_abnormal_autophagy0.32193783
97MP0000003_abnormal_adipose_tissue0.31650033
98MP0002108_abnormal_muscle_morphology0.30352682
99MP0009250_abnormal_appendicular_skeleto0.30228282
100MP0000733_abnormal_muscle_development0.29203770
101MP0000749_muscle_degeneration0.29151766
102MP0002138_abnormal_hepatobiliary_system0.28638741
103MP0003448_altered_tumor_morphology0.27984557
104MP0002697_abnormal_eye_size0.27741854
105MP0002233_abnormal_nose_morphology0.27730204
106MP0004130_abnormal_muscle_cell0.27653813
107MP0001485_abnormal_pinna_reflex0.27469553
108MP0002006_tumorigenesis0.26660534
109MP0004197_abnormal_fetal_growth/weight/0.26490589
110MP0003045_fibrosis0.26468376
111MP0005390_skeleton_phenotype0.26312520
112MP0000432_abnormal_head_morphology0.26163951
113MP0002970_abnormal_white_adipose0.24426463
114MP0008789_abnormal_olfactory_epithelium0.24385236
115MP0001299_abnormal_eye_distance/0.20617768
116MP0000747_muscle_weakness0.20583706
117MP0005394_taste/olfaction_phenotype0.20303926
118MP0005499_abnormal_olfactory_system0.20303926
119MP0008961_abnormal_basal_metabolism0.20112174
120MP0001186_pigmentation_phenotype0.19929954
121MP0005257_abnormal_intraocular_pressure0.19873049
122MP0002115_abnormal_skeleton_extremities0.19795523
123MP0000163_abnormal_cartilage_morphology0.19390632
124MP0004087_abnormal_muscle_fiber0.18931698
125MP0000685_abnormal_immune_system0.15798899
126MP0000569_abnormal_digit_pigmentation0.15724013
127MP0009672_abnormal_birth_weight0.15168604
128MP0009333_abnormal_splenocyte_physiolog0.15043578
129MP0001984_abnormal_olfaction0.14953175
130MP0000428_abnormal_craniofacial_morphol0.13068739
131MP0004043_abnormal_pH_regulation0.12203289
132MP0005193_abnormal_anterior_eye0.11328229

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)9.18369851
2* Hypotrichosis (HP:0001006)7.89167666
3Woolly hair (HP:0002224)7.57632563
4Palmoplantar hyperkeratosis (HP:0000972)7.03524317
5* Increased IgE level (HP:0003212)6.73642028
6Plantar hyperkeratosis (HP:0007556)6.65930829
7Palmar hyperkeratosis (HP:0010765)6.65787248
8Erythroderma (HP:0001019)6.16468476
9Congenital ichthyosiform erythroderma (HP:0007431)6.15869049
10Thick nail (HP:0001805)6.09992562
11Abnormality of secondary sexual hair (HP:0009888)5.94873413
12Abnormality of the axillary hair (HP:0100134)5.94873413
13Right ventricular cardiomyopathy (HP:0011663)5.94237691
14Pili torti (HP:0003777)5.79578820
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.71155723
16Conjunctival hamartoma (HP:0100780)5.47502930
17Fragile nails (HP:0001808)5.27994413
18Follicular hyperkeratosis (HP:0007502)4.90800346
19Alopecia of scalp (HP:0002293)4.73988195
20Nail dystrophy (HP:0008404)4.59596686
21Brittle hair (HP:0002299)4.22193035
22Milia (HP:0001056)4.21604409
23Abnormal blistering of the skin (HP:0008066)4.11917250
24* Erythema (HP:0010783)4.09772752
25Absent eyelashes (HP:0000561)3.90159493
26Oral leukoplakia (HP:0002745)3.85282669
27Gangrene (HP:0100758)3.60325921
28Abnormal hair laboratory examination (HP:0003328)3.55886421
29Hamartoma of the eye (HP:0010568)3.52389467
30Absent hair (HP:0002298)3.44586066
31Parakeratosis (HP:0001036)3.43962279
32Palmoplantar keratoderma (HP:0000982)3.35550178
33Ectropion (HP:0000656)3.30995830
34Corneal erosion (HP:0200020)3.30846742
35Natal tooth (HP:0000695)3.23219421
36Type 1 muscle fiber predominance (HP:0003803)3.21845582
37Acanthosis nigricans (HP:0000956)3.20419204
38Advanced eruption of teeth (HP:0006288)3.18894928
39Sparse eyelashes (HP:0000653)3.14622643
40Hyporeflexia of lower limbs (HP:0002600)3.12459897
41Curly hair (HP:0002212)3.11829117
42Hypohidrosis (HP:0000966)3.08554729
43Abnormality of hair growth rate (HP:0011363)3.08263057
44Slow-growing hair (HP:0002217)3.08263057
45Abnormality of the salivary glands (HP:0010286)3.05995808
46Ventricular tachycardia (HP:0004756)2.94783170
47Atrophic scars (HP:0001075)2.88230176
48Increased connective tissue (HP:0009025)2.86906275
49Ridged nail (HP:0001807)2.86692370
50Furrowed tongue (HP:0000221)2.76471889
51Lip pit (HP:0100267)2.66130397
52Pustule (HP:0200039)2.60850167
53Distal lower limb muscle weakness (HP:0009053)2.56864902
54Premature rupture of membranes (HP:0001788)2.49379088
55Round ear (HP:0100830)2.44086583
56Fatigable weakness (HP:0003473)2.43548547
57Abnormality of the neuromuscular junction (HP:0003398)2.43548547
58Amniotic constriction ring (HP:0009775)2.37579316
59Abnormality of placental membranes (HP:0011409)2.37579316
60Sparse scalp hair (HP:0002209)2.32139619
61Laryngomalacia (HP:0001601)2.30609398
62Hypoplastic labia majora (HP:0000059)2.27634165
63* Onycholysis (HP:0001806)2.25577009
64Autoamputation (HP:0001218)2.25481604
65Corneal dystrophy (HP:0001131)2.24312616
66Lack of skin elasticity (HP:0100679)2.22190247
67Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.16875521
68* Pruritus (HP:0000989)2.16221631
69Muscle fiber inclusion bodies (HP:0100299)2.14919964
70Protrusio acetabuli (HP:0003179)2.09310847
71Nemaline bodies (HP:0003798)2.07695025
72Eczematoid dermatitis (HP:0000976)2.06865528
73Abnormality of the labia majora (HP:0012881)2.06276349
74Nasolacrimal duct obstruction (HP:0000579)2.06031308
75Hyperhidrosis (HP:0000975)2.05770058
76Dry hair (HP:0011359)2.03282130
77Distal arthrogryposis (HP:0005684)2.02418186
78Duplicated collecting system (HP:0000081)2.02375716
79Fragile skin (HP:0001030)2.02297086
80Concave nail (HP:0001598)1.95312876
81Anonychia (HP:0001798)1.94817948
82Paralysis (HP:0003470)1.94353555
83Selective tooth agenesis (HP:0001592)1.93457033
84Multifactorial inheritance (HP:0001426)1.93113645
85Achilles tendon contracture (HP:0001771)1.93062384
86Neck muscle weakness (HP:0000467)1.89028454
87Spinal rigidity (HP:0003306)1.87036416
88Myopathic facies (HP:0002058)1.86788961
89Fine hair (HP:0002213)1.86592164
90Calcaneovalgus deformity (HP:0001848)1.86013392
91Congenital, generalized hypertrichosis (HP:0004540)1.85396776
92Ulnar deviation of the wrist (HP:0003049)1.84870996
93Urticaria (HP:0001025)1.82810687
94Recurrent corneal erosions (HP:0000495)1.82636336
95Blepharitis (HP:0000498)1.81436478
96Muscle fiber splitting (HP:0003555)1.80085385
97Ventricular fibrillation (HP:0001663)1.80034837
98Sudden death (HP:0001699)1.79787614
99Septate vagina (HP:0001153)1.75813967
100Carious teeth (HP:0000670)1.75367969
101Difficulty running (HP:0009046)1.75282604
102* Hypergammaglobulinemia (HP:0010702)1.75062808
103Split foot (HP:0001839)1.74115896
104Abnormality of the Achilles tendon (HP:0005109)1.73464755
105Mildly elevated creatine phosphokinase (HP:0008180)1.73362029
106Dry skin (HP:0000958)1.72624698
107Keratoconjunctivitis sicca (HP:0001097)1.72393418
108Abnormality of skeletal muscle fiber size (HP:0012084)1.72157525
109Abnormality of the renal collecting system (HP:0004742)1.71753529
110Increased variability in muscle fiber diameter (HP:0003557)1.71741308
111Malignant hyperthermia (HP:0002047)1.69500097
112Abnormality of the gastric mucosa (HP:0004295)1.69434184
113Verrucae (HP:0200043)1.69422686
114Papilloma (HP:0012740)1.69422686
115Distal lower limb amyotrophy (HP:0008944)1.69125174
116Sepsis (HP:0100806)1.68950833
117Ankle contracture (HP:0006466)1.68215757
118Slender build (HP:0001533)1.67423537
119Areflexia of lower limbs (HP:0002522)1.66676848
120Oligodontia (HP:0000677)1.65121959
121Deformed tarsal bones (HP:0008119)1.64523446
122Xerostomia (HP:0000217)1.64443005
123Abnormality of the dental root (HP:0006486)1.64395679
124Taurodontia (HP:0000679)1.64395679
125Abnormality of permanent molar morphology (HP:0011071)1.64395679
126Dehydration (HP:0001944)1.63656097
127Skin ulcer (HP:0200042)1.63333843
128Depressed nasal tip (HP:0000437)1.61268625
129Neonatal short-limb short stature (HP:0008921)1.61146954
130Abnormality of the lacrimal duct (HP:0011481)1.58978366
131Aplasia cutis congenita (HP:0001057)1.57890798
132Abnormality of molar morphology (HP:0011070)1.57405044
133Abnormality of molar (HP:0011077)1.57405044
134Keratoconjunctivitis (HP:0001096)1.54495213
135Hamartoma (HP:0010566)1.54439965
136Amelogenesis imperfecta (HP:0000705)1.54120143
137Conical tooth (HP:0000698)1.54034184
138Anhidrosis (HP:0000970)1.52990692
139Melanocytic nevus (HP:0000995)1.52759878
140Abnormality of the fingernails (HP:0001231)1.52141367
141Abnormality of the dental pulp (HP:0006479)1.45393659
142Abnormality of the nasolacrimal system (HP:0000614)1.38958500

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR15.40021848
2MAPKAPK34.96905247
3FER4.54948389
4ERN13.43229193
5MST1R3.37054592
6TRIB33.18017817
7TTN2.80995507
8MAP3K32.79619761
9LATS12.78294464
10EPHB22.67123467
11PIK3CG2.62671500
12MST42.49835491
13BCR2.16960126
14SGK2232.11334455
15SGK4942.11334455
16TAOK12.10003694
17RPS6KB22.06301791
18FGFR11.96019153
19EPHA21.88237889
20DDR21.83787364
21LATS21.73195801
22MAP3K21.70811822
23EEF2K1.68582728
24WNK11.64962083
25OBSCN1.56676170
26EPHB11.50915825
27RIPK11.49061586
28EPHA31.45693325
29MAP3K61.39402277
30MAP3K111.37145443
31MAPK71.36795125
32TRPM71.36100160
33MAP3K91.33476160
34SIK11.31545446
35PTK61.30068396
36FGFR41.28299171
37LRRK21.28151439
38BLK1.24314582
39PIM21.23496626
40IRAK11.17359909
41GRK61.16717448
42MET1.15598919
43PDGFRA1.15276215
44STK241.15181607
45CDK121.12000805
46FGFR31.11315010
47CDK61.10946684
48MAP2K31.07544367
49FGFR21.01133340
50MAP2K60.99630959
51RPS6KA40.98401278
52MAP3K10.98138763
53IKBKB0.97863521
54NME10.94765170
55MAPKAPK20.94729049
56DYRK1B0.92309968
57MAP3K70.91594595
58PRPF4B0.89220841
59SGK20.86463775
60MAPKAPK50.84331231
61MAP2K10.82287163
62RPS6KB10.80850198
63SGK30.80563882
64CAMK1D0.79684914
65DMPK0.79530570
66EPHA40.74335856
67MAP3K120.72975315
68NLK0.72088708
69PTK20.68483480
70BMX0.67966958
71ADRBK10.67675005
72PKN20.67527395
73PRKD10.67312224
74STK30.63562244
75STK100.62979231
76TGFBR20.58486849
77ILK0.53440166
78KSR20.52282118
79PBK0.51131089
80CDC42BPA0.50189746
81PRKCI0.48931976
82SGK10.48730126
83PHKG20.47106797
84PHKG10.47106797
85TIE10.46964894
86ROCK10.45905574
87ERBB30.45010950
88TESK10.44580814
89STK38L0.44172200
90NTRK20.44089952
91PAK30.43936727
92PDK40.42532189
93PDK30.42532189
94FLT30.41943706
95MAPK120.41393672
96TAOK20.39878852
97RPS6KA20.39455678
98TYRO30.39031028
99IRAK20.38778035
100MAPK110.37962341
101JAK30.37877734
102RPS6KA10.36722717
103ICK0.36699215
104JAK10.36342882
105PDK20.34506807
106TYK20.33697404
107NEK60.32598997
108MAP2K40.32309876
109PRKD20.30672273
110AKT30.30466092
111IKBKE0.29775977
112PAK20.29203109
113ABL10.28909312
114PRKCE0.28867784
115PKN10.28125140
116HIPK20.27922141
117PRKAA20.27701980
118KIT0.27570227
119BRD40.27018976
120GSK3A0.26890947
121ROCK20.25313164
122MTOR0.25139127
123MARK20.24133817
124PDGFRB0.24084511
125CSNK1D0.22744015
126MAPK90.22714355
127STK110.22293503
128MAPK40.22248712
129RET0.22205038
130HCK0.22096937
131ABL20.20553074
132SMG10.20502168
133SRC0.19831225
134STK380.19723100
135MAP3K50.19584398
136ERBB20.18839891

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.59412860
2Linoleic acid metabolism_Homo sapiens_hsa005913.58620305
3Fatty acid elongation_Homo sapiens_hsa000622.97929273
4Arachidonic acid metabolism_Homo sapiens_hsa005902.38711941
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.34455350
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.29113050
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.21665766
8ECM-receptor interaction_Homo sapiens_hsa045122.11743398
9Ovarian steroidogenesis_Homo sapiens_hsa049132.05993342
10Fat digestion and absorption_Homo sapiens_hsa049752.02886587
11Basal cell carcinoma_Homo sapiens_hsa052171.85961050
12Sphingolipid metabolism_Homo sapiens_hsa006001.84379850
13Ether lipid metabolism_Homo sapiens_hsa005651.78748351
14VEGF signaling pathway_Homo sapiens_hsa043701.70060414
15Phenylalanine metabolism_Homo sapiens_hsa003601.67200888
16Adherens junction_Homo sapiens_hsa045201.60063750
17Tight junction_Homo sapiens_hsa045301.54869996
18Proteoglycans in cancer_Homo sapiens_hsa052051.51418662
19Fatty acid biosynthesis_Homo sapiens_hsa000611.50996849
20Circadian rhythm_Homo sapiens_hsa047101.45252478
21GnRH signaling pathway_Homo sapiens_hsa049121.40692591
22Bladder cancer_Homo sapiens_hsa052191.39602052
23Staphylococcus aureus infection_Homo sapiens_hsa051501.39202283
24PPAR signaling pathway_Homo sapiens_hsa033201.36695314
25Choline metabolism in cancer_Homo sapiens_hsa052311.34778553
26Serotonergic synapse_Homo sapiens_hsa047261.33802808
27Melanogenesis_Homo sapiens_hsa049161.27011623
28Axon guidance_Homo sapiens_hsa043601.26924418
29Amoebiasis_Homo sapiens_hsa051461.26300029
30Hippo signaling pathway_Homo sapiens_hsa043901.21357204
31Steroid biosynthesis_Homo sapiens_hsa001001.19369756
32Acute myeloid leukemia_Homo sapiens_hsa052211.18415955
33Protein digestion and absorption_Homo sapiens_hsa049741.16433217
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16169963
35Glioma_Homo sapiens_hsa052141.15857598
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.14116148
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.13735708
38Focal adhesion_Homo sapiens_hsa045101.12699543
39Histidine metabolism_Homo sapiens_hsa003401.12443733
40Hedgehog signaling pathway_Homo sapiens_hsa043401.11890421
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10051756
42Phototransduction_Homo sapiens_hsa047441.09831043
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07381558
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05270559
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03438958
46Renin secretion_Homo sapiens_hsa049241.03062493
47Ras signaling pathway_Homo sapiens_hsa040141.00137250
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98850507
49TGF-beta signaling pathway_Homo sapiens_hsa043500.94045834
50p53 signaling pathway_Homo sapiens_hsa041150.93672323
51Melanoma_Homo sapiens_hsa052180.93082775
52MicroRNAs in cancer_Homo sapiens_hsa052060.92977292
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91719498
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90960475
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.87635469
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.86865609
57Retinol metabolism_Homo sapiens_hsa008300.86147362
58Thyroid cancer_Homo sapiens_hsa052160.82102626
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.82010211
60Insulin resistance_Homo sapiens_hsa049310.81328353
61Pertussis_Homo sapiens_hsa051330.81156561
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.81012555
63Caffeine metabolism_Homo sapiens_hsa002320.80007915
64Platelet activation_Homo sapiens_hsa046110.78340007
65Estrogen signaling pathway_Homo sapiens_hsa049150.77268095
66Tyrosine metabolism_Homo sapiens_hsa003500.77024904
67ABC transporters_Homo sapiens_hsa020100.76907656
68Rap1 signaling pathway_Homo sapiens_hsa040150.75946444
69Gastric acid secretion_Homo sapiens_hsa049710.75128385
70Glycerolipid metabolism_Homo sapiens_hsa005610.75046702
71Dorso-ventral axis formation_Homo sapiens_hsa043200.73959677
72Oxytocin signaling pathway_Homo sapiens_hsa049210.71262067
73Toxoplasmosis_Homo sapiens_hsa051450.70066985
74Long-term depression_Homo sapiens_hsa047300.69885295
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68790831
76Glutamatergic synapse_Homo sapiens_hsa047240.67914639
77Hepatitis C_Homo sapiens_hsa051600.67740297
78Pancreatic secretion_Homo sapiens_hsa049720.67590399
79Fatty acid metabolism_Homo sapiens_hsa012120.67476893
80Wnt signaling pathway_Homo sapiens_hsa043100.65380821
81Salivary secretion_Homo sapiens_hsa049700.64463597
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63355590
83ErbB signaling pathway_Homo sapiens_hsa040120.63123651
84Insulin signaling pathway_Homo sapiens_hsa049100.62228273
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62065779
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.60460072
87Small cell lung cancer_Homo sapiens_hsa052220.59504237
88Dilated cardiomyopathy_Homo sapiens_hsa054140.59317049
89Inositol phosphate metabolism_Homo sapiens_hsa005620.57523031
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57484687
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.54040377
92Glucagon signaling pathway_Homo sapiens_hsa049220.53010082
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52993233
94Long-term potentiation_Homo sapiens_hsa047200.51299433
95Endocytosis_Homo sapiens_hsa041440.50270709
96Malaria_Homo sapiens_hsa051440.50039578
97AMPK signaling pathway_Homo sapiens_hsa041520.49348254
98Non-small cell lung cancer_Homo sapiens_hsa052230.49131920
99Pathways in cancer_Homo sapiens_hsa052000.49086787
100Endometrial cancer_Homo sapiens_hsa052130.48920261
101Tuberculosis_Homo sapiens_hsa051520.45439550
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45225107
103Collecting duct acid secretion_Homo sapiens_hsa049660.44583474
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44496931
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43802053
106Renal cell carcinoma_Homo sapiens_hsa052110.43586201
107beta-Alanine metabolism_Homo sapiens_hsa004100.43471945
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43042010
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42989164
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42498676
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42163020
112Mineral absorption_Homo sapiens_hsa049780.41497106
113Notch signaling pathway_Homo sapiens_hsa043300.41236947
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41009906
115Fatty acid degradation_Homo sapiens_hsa000710.40965791
116Arginine biosynthesis_Homo sapiens_hsa002200.40951277
117MAPK signaling pathway_Homo sapiens_hsa040100.40583925
118Vitamin digestion and absorption_Homo sapiens_hsa049770.36354173
119Pancreatic cancer_Homo sapiens_hsa052120.31604590
120cAMP signaling pathway_Homo sapiens_hsa040240.30347643
121Salmonella infection_Homo sapiens_hsa051320.29957502
122HIF-1 signaling pathway_Homo sapiens_hsa040660.27394002
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26056799
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.24462478
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23817065
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.23311734
127Amphetamine addiction_Homo sapiens_hsa050310.23218934

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