CDX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)8.37616979
2regulation of guanylate cyclase activity (GO:0031282)7.73839185
3negative regulation of epidermis development (GO:0045683)7.32179926
4regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.20077767
5aminoglycoside antibiotic metabolic process (GO:0030647)6.64979177
6somite rostral/caudal axis specification (GO:0032525)6.56721600
7intestinal absorption (GO:0050892)6.55598912
8maintenance of protein location in nucleus (GO:0051457)6.37509692
9regulation of mammary gland epithelial cell proliferation (GO:0033599)6.32757224
10negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.27313214
11NADH metabolic process (GO:0006734)6.13729868
12intestinal epithelial cell development (GO:0060576)6.11104366
13negative regulation of epidermal cell differentiation (GO:0045605)5.93243999
14muscle organ morphogenesis (GO:0048644)5.84468000
15positive regulation of respiratory burst (GO:0060267)5.83725012
16positive regulation of guanylate cyclase activity (GO:0031284)5.72383805
17regulation of response to osmotic stress (GO:0047484)5.66332422
18protein localization to kinetochore (GO:0034501)5.62793978
19negative regulation of cell cycle G2/M phase transition (GO:1902750)5.62288833
20regulation of cellular extravasation (GO:0002691)5.59025913
21cytidine metabolic process (GO:0046087)5.46850012
22cytidine catabolic process (GO:0006216)5.46850012
23cytidine deamination (GO:0009972)5.46850012
24negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.36568257
25positive regulation of pseudopodium assembly (GO:0031274)5.32163014
26regulation of nuclear cell cycle DNA replication (GO:0033262)5.20725100
27regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.16670151
28endocrine process (GO:0050886)5.16670151
29regulation of systemic arterial blood pressure by hormone (GO:0001990)5.16670151
30regulation of MHC class I biosynthetic process (GO:0045343)5.15110184
31phenol-containing compound catabolic process (GO:0019336)5.14451872
32negative regulation of telomerase activity (GO:0051974)5.11508969
33histone H4-K8 acetylation (GO:0043982)5.07006375
34histone H4-K5 acetylation (GO:0043981)5.07006375
35hormone catabolic process (GO:0042447)5.06190461
36fat-soluble vitamin biosynthetic process (GO:0042362)5.05979620
37heterochromatin organization (GO:0070828)5.03492180
38rRNA transcription (GO:0009303)5.01076756
39antibacterial humoral response (GO:0019731)4.99550203
40histone H4-K12 acetylation (GO:0043983)4.96430415
41regulation of telomere maintenance via telomerase (GO:0032210)4.93111281
42notochord development (GO:0030903)4.87185399
43renal system process involved in regulation of blood volume (GO:0001977)4.86573961
44antimicrobial humoral response (GO:0019730)4.84672869
45receptor guanylyl cyclase signaling pathway (GO:0007168)4.76825209
46regulation of pseudopodium assembly (GO:0031272)4.76817601
47regulation of apoptotic process involved in morphogenesis (GO:1902337)4.74558505
48regulation of cGMP biosynthetic process (GO:0030826)4.70413483
49lipoprotein transport (GO:0042953)4.68828042
50regulation of systemic arterial blood pressure (GO:0003073)4.66066313
51vitamin A metabolic process (GO:0006776)4.65739573
52glomerular filtration (GO:0003094)4.59647421
53GDP-mannose metabolic process (GO:0019673)4.54661963
54mitotic sister chromatid segregation (GO:0000070)4.54515064
55branching involved in mammary gland duct morphogenesis (GO:0060444)4.49636157
56regulation of vitamin metabolic process (GO:0030656)4.47728138
57regulation of cilium movement (GO:0003352)4.44968964
58cellular glucuronidation (GO:0052695)4.43840095
59fructose metabolic process (GO:0006000)4.38688058
60uronic acid metabolic process (GO:0006063)4.38618558
61glucuronate metabolic process (GO:0019585)4.38618558
62regulation of bile acid biosynthetic process (GO:0070857)4.36998325
63bile acid and bile salt transport (GO:0015721)4.31129675
64rRNA methylation (GO:0031167)4.29860121
65diacylglycerol metabolic process (GO:0046339)4.28398156
66maintenance of gastrointestinal epithelium (GO:0030277)4.26340321
67urea cycle (GO:0000050)4.21190467
68renal filtration (GO:0097205)4.15956137
69regulation of respiratory burst (GO:0060263)4.13592136
70response to dietary excess (GO:0002021)4.13558376
71nucleoside transmembrane transport (GO:1901642)4.11071663
72protein localization to chromosome, centromeric region (GO:0071459)4.10016516
73cardiovascular system development (GO:0072358)4.09860906
74transepithelial transport (GO:0070633)4.09309528
75calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.09090878
76primitive streak formation (GO:0090009)4.04371086
77chromatin assembly (GO:0031497)4.04135975
78sulfate transmembrane transport (GO:1902358)4.03948850
79oligosaccharide biosynthetic process (GO:0009312)4.03662936
80interferon-gamma production (GO:0032609)4.03158626
81primary alcohol catabolic process (GO:0034310)4.00784341
82rRNA modification (GO:0000154)3.99674495
83regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.97750980
84urea metabolic process (GO:0019627)3.96435377
85positive regulation of DNA-dependent DNA replication (GO:2000105)3.95341412
86quinone metabolic process (GO:1901661)3.91221964
87regulation of translation in response to stress (GO:0043555)3.89671938
88drug metabolic process (GO:0017144)3.87811530
89regulation of cGMP metabolic process (GO:0030823)3.87349007
90virion attachment to host cell (GO:0019062)3.86791429
91adhesion of symbiont to host cell (GO:0044650)3.86791429
92positive regulation of glycoprotein biosynthetic process (GO:0010560)3.86734950
93nucleoside diphosphate biosynthetic process (GO:0009133)3.84435931
94pyrimidine ribonucleoside catabolic process (GO:0046133)3.81927953
95trophectodermal cell differentiation (GO:0001829)3.81755937
96cGMP-mediated signaling (GO:0019934)3.81332889
97cell fate commitment involved in formation of primary germ layer (GO:0060795)3.80670999
98ethanol oxidation (GO:0006069)3.78889376
99DNA replication-dependent nucleosome organization (GO:0034723)3.73050037
100DNA replication-dependent nucleosome assembly (GO:0006335)3.73050037
101sister chromatid segregation (GO:0000819)3.73004179
102bundle of His cell to Purkinje myocyte communication (GO:0086069)3.68213333
103maintenance of protein localization in organelle (GO:0072595)3.68194614
104flavonoid metabolic process (GO:0009812)3.67269561
105positive regulation of Cdc42 GTPase activity (GO:0043089)3.66480249
106positive regulation of glycoprotein metabolic process (GO:1903020)3.66473756
107epoxygenase P450 pathway (GO:0019373)3.66457216
108nitrogen cycle metabolic process (GO:0071941)3.66367691
109transcytosis (GO:0045056)3.66335957
110cellular modified amino acid catabolic process (GO:0042219)3.63669150
111histone H4-K16 acetylation (GO:0043984)3.62247862
112intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.61111587
113negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.59451980
114antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58944883
115vitamin transmembrane transport (GO:0035461)3.58167949
116regulation of cholesterol homeostasis (GO:2000188)3.57282168
117mitochondrion distribution (GO:0048311)3.55771782
118signal transduction involved in regulation of gene expression (GO:0023019)3.52675552
119intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.51549413
120coenzyme catabolic process (GO:0009109)3.51443927
121glycosphingolipid catabolic process (GO:0046479)3.51272750
122DNA replication checkpoint (GO:0000076)3.49669765
123negative regulation of telomere maintenance (GO:0032205)3.48986164
124nuclear pore complex assembly (GO:0051292)3.47583878
125glycolipid catabolic process (GO:0019377)3.46774523
126UDP-N-acetylglucosamine metabolic process (GO:0006047)3.46696234
127phenylpropanoid metabolic process (GO:0009698)3.46588632
128antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.44402222
129thyroid hormone generation (GO:0006590)3.44319541
130arginine metabolic process (GO:0006525)3.42658760
131digestion (GO:0007586)3.42416251
132renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.42185959
133actin filament depolymerization (GO:0030042)3.41915990
134peptide catabolic process (GO:0043171)3.41582191
135very-low-density lipoprotein particle assembly (GO:0034379)3.41057064
136glucocorticoid biosynthetic process (GO:0006704)3.40168653
137phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.39907981
138peptide hormone processing (GO:0016486)3.37802370
139proline transport (GO:0015824)3.36900066
140regulation of telomerase activity (GO:0051972)3.34510212
141complement activation, classical pathway (GO:0006958)3.33703877
142O-glycan processing (GO:0016266)3.33352901
143eosinophil chemotaxis (GO:0048245)3.32541079
144branching involved in labyrinthine layer morphogenesis (GO:0060670)3.31686064
145desmosome organization (GO:0002934)3.30520980
146positive regulation of cGMP biosynthetic process (GO:0030828)3.30444879
147antigen processing and presentation of endogenous antigen (GO:0019883)3.30184106
148maternal placenta development (GO:0001893)3.29285875
149arachidonic acid secretion (GO:0050482)3.28584063
150icosanoid secretion (GO:0032309)3.28584063
151digestive system process (GO:0022600)3.27838124
152positive regulation of digestive system process (GO:0060456)3.26324526
153sulfate transport (GO:0008272)3.25398464
154adhesion of symbiont to host (GO:0044406)3.25337370
155hypotonic response (GO:0006971)3.24609438
156sulfur amino acid catabolic process (GO:0000098)3.23557503
157nucleoside transport (GO:0015858)3.23127382
158thyroid hormone metabolic process (GO:0042403)3.17264094
159microtubule severing (GO:0051013)3.15609232
160auditory receptor cell differentiation (GO:0042491)3.14720006
161omega-hydroxylase P450 pathway (GO:0097267)3.13880103
162bone trabecula formation (GO:0060346)3.13213892
163regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.11765746
164epithelial structure maintenance (GO:0010669)3.10910479
165positive regulation of fatty acid beta-oxidation (GO:0032000)3.10793964
166fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.10170886
167labyrinthine layer development (GO:0060711)3.10071438
168mRNA stabilization (GO:0048255)3.09848620
169RNA stabilization (GO:0043489)3.09848620
170positive regulation of protein deacetylation (GO:0090312)3.09405807
171detection of temperature stimulus (GO:0016048)3.08791631
172apoptotic DNA fragmentation (GO:0006309)3.07043801
173retinoic acid receptor signaling pathway (GO:0048384)3.06127585
174tachykinin receptor signaling pathway (GO:0007217)3.02898088
175transcription from mitochondrial promoter (GO:0006390)3.02557495
176DNA damage response, detection of DNA damage (GO:0042769)3.02064255
177vitamin transport (GO:0051180)3.01813211
178receptor recycling (GO:0001881)3.00208432
179regulation of epidermis development (GO:0045682)3.00065104
180fucosylation (GO:0036065)2.97963295
181sphingomyelin metabolic process (GO:0006684)2.97898980
182glutamine family amino acid biosynthetic process (GO:0009084)2.97307554
183eosinophil migration (GO:0072677)2.94508327
184alkaloid metabolic process (GO:0009820)2.94449335
185response to nitric oxide (GO:0071731)2.94249090
186glycosylceramide metabolic process (GO:0006677)2.92756942
187cGMP biosynthetic process (GO:0006182)2.91928064
188ethanol metabolic process (GO:0006067)2.91874975
189thrombin receptor signaling pathway (GO:0070493)2.90430015
190plasma lipoprotein particle assembly (GO:0034377)2.88918995
191sphingolipid catabolic process (GO:0030149)2.87821930
192sulfur compound transport (GO:0072348)2.87610112
193cellular response to nitric oxide (GO:0071732)2.85867702
194polyketide metabolic process (GO:0030638)10.3734248
195doxorubicin metabolic process (GO:0044598)10.3734248
196daunorubicin metabolic process (GO:0044597)10.3734248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.60367761
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.60367761
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.60367761
4BP1_19119308_ChIP-ChIP_Hs578T_Human6.31878848
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.91321036
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.73859252
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.59168656
8E2F7_22180533_ChIP-Seq_HELA_Human3.44100169
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.34185787
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.24445111
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.97140074
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.87446451
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.85227493
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.81046733
15* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.72430621
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.64503076
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.64096337
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.54593898
19* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.53068428
20* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.52972110
21SOX2_20726797_ChIP-Seq_SW620_Human2.46084887
22* CDX2_20551321_ChIP-Seq_CACO-2_Human2.43882162
23* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.42342283
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.42129780
25RXR_22158963_ChIP-Seq_LIVER_Mouse2.37913943
26PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37829098
27* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.19605776
28* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.13785968
29* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.08280911
30* NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.07179910
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03391905
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.02288903
33CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00265406
34LXR_22158963_ChIP-Seq_LIVER_Mouse1.99766511
35* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.99589487
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.97301385
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96582588
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.92347459
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.91005986
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.89200417
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76469775
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76379798
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.74084700
44PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.71930046
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65843688
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.64911271
47POU5F1_16518401_ChIP-PET_MESCs_Mouse1.63240236
48* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62337174
49ZNF263_19887448_ChIP-Seq_K562_Human1.61047715
50* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.59716479
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59491105
52* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.58763824
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56120521
54CLOCK_20551151_ChIP-Seq_293T_Human1.55597354
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53676928
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52987856
57* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.52867622
58* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.52493134
59IRF1_19129219_ChIP-ChIP_H3396_Human1.50907134
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50261612
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.49112330
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48926838
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46707525
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.46334307
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45100992
66* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.43743058
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42998660
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.40884777
69* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.38721394
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37943313
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34422693
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33492456
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33162909
74PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.32677923
75TCF4_18268006_ChIP-ChIP_LS174T_Human1.32024270
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.31916506
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.30474259
78E2F1_17053090_ChIP-ChIP_MCF-7_Human1.28599230
79MYC_18555785_ChIP-Seq_MESCs_Mouse1.27975972
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.26812527
81JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.24555704
82SA1_27219007_Chip-Seq_Bcells_Human1.23714754
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23161474
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22305568
85* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21126407
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20302697
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19178637
88BCL6_27268052_Chip-Seq_Bcells_Human1.18580450
89* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17921818
90GATA6_25053715_ChIP-Seq_YYC3_Human1.17831253
91HNF4A_19822575_ChIP-Seq_HepG2_Human1.13437709
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13107879
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12878175
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.12744571
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12144802
96FOXA1_25552417_ChIP-Seq_VCAP_Human1.11648807
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11479835
98* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08397890
99CTCF_27219007_Chip-Seq_Bcells_Human1.06919070
100* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05712643
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05327232
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04901465
103RACK7_27058665_Chip-Seq_MCF-7_Human1.04068515
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03994268
105NANOG_16518401_ChIP-PET_MESCs_Mouse1.03964447
106MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02521154
107MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02476409
108CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01834504
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01547676
110DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99746564
111EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99615885
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99251701
113GATA2_19941826_ChIP-Seq_K562_Human0.98980803
114SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98626936
115TP53_22127205_ChIP-Seq_IMR90_Human0.98418535
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97307493
117NCOR1_26117541_ChIP-Seq_K562_Human0.97243711
118IRF8_21731497_ChIP-ChIP_J774_Mouse0.96667643
119EGR1_19032775_ChIP-ChIP_M12_Human0.95333819
120GATA1_19941826_ChIP-Seq_K562_Human0.94649090
121* CDX2_22108803_ChIP-Seq_LS180_Human0.94392251
122CEBPB_22108803_ChIP-Seq_LS180_Human0.94377582
123DROSHA_22980978_ChIP-Seq_HELA_Human0.94143148
124SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94129106
125CREB1_26743006_Chip-Seq_LNCaP_Human0.92731794
126GATA3_24758297_ChIP-Seq_MCF-7_Human0.92000953
127VDR_24763502_ChIP-Seq_THP-1_Human0.91973061
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.91854147
129* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91539053
130TP63_22573176_ChIP-Seq_HFKS_Human0.91122882
131NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91058274
132ETS1_21867929_ChIP-Seq_TH2_Mouse0.90481619
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.90171877
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88914252
135KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88715876
136FOXA2_19822575_ChIP-Seq_HepG2_Human0.88673218
137* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88636004
138STAT1_20625510_ChIP-Seq_HELA_Human0.88506873
139MYC_18358816_ChIP-ChIP_MESCs_Mouse0.87888784
140NANOG_20526341_ChIP-Seq_ESCs_Human0.87880109
141VDR_21846776_ChIP-Seq_THP-1_Human0.87391227
142SMC4_20622854_ChIP-Seq_HELA_Human0.87272936
143GATA4_25053715_ChIP-Seq_YYC3_Human0.86946813
144* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86834928
145TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86625264
146STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84224099
147AR_21909140_ChIP-Seq_LNCAP_Human0.84155961
148MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84022734
149MYC_22102868_ChIP-Seq_BL_Human0.83678854
150KAP1_27257070_Chip-Seq_ESCs_Mouse0.82774634
151* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.80200414
152NANOG_21062744_ChIP-ChIP_HESCs_Human0.80086666
153NOTCH1_21737748_ChIP-Seq_TLL_Human0.79140789
154* NANOG_16153702_ChIP-ChIP_HESCs_Human0.77985094
155LXR_22292898_ChIP-Seq_THP-1_Human0.76264032
156EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.75952972
157CREB1_15753290_ChIP-ChIP_HEK293T_Human0.75800657
158KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75672384
159THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75216841
160CTCF_21964334_Chip-Seq_Bcells_Human0.74554671
161KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74300979
162ELK3_25401928_ChIP-Seq_HUVEC_Human0.72968484
163YY1_22570637_ChIP-Seq_MALME-3M_Human0.72895533
164BCOR_27268052_Chip-Seq_Bcells_Human0.72287969
165STAT3_18555785_ChIP-Seq_MESCs_Mouse0.71700327
166* TCF7_22412390_ChIP-Seq_EML_Mouse0.70162237
167SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.69388852
168TBX3_20139965_ChIP-Seq_ESCs_Mouse0.69228044
169KLF5_25053715_ChIP-Seq_YYC3_Human0.68694010
170PHF8_20622854_ChIP-Seq_HELA_Human0.68661012
171PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68269474
172TBX3_20139965_ChIP-Seq_MESCs_Mouse0.68065767
173P68_20966046_ChIP-Seq_HELA_Human0.66749615
174IKZF1_21737484_ChIP-ChIP_HCT116_Human0.66535872
175ATF3_27146783_Chip-Seq_COLON_Human0.66528323
176TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.65281325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.91698532
2MP0004264_abnormal_extraembryonic_tissu5.61780700
3MP0002139_abnormal_hepatobiliary_system4.92511339
4MP0003011_delayed_dark_adaptation4.26867983
5MP0009379_abnormal_foot_pigmentation3.82214046
6MP0005085_abnormal_gallbladder_physiolo3.78207944
7MP0001666_abnormal_nutrient_absorption3.75360477
8MP0006292_abnormal_olfactory_placode3.44082649
9MP0010352_gastrointestinal_tract_polyps3.16460034
10MP0004858_abnormal_nervous_system3.15841209
11MP0003890_abnormal_embryonic-extraembry3.02205535
12MP0005499_abnormal_olfactory_system2.96834866
13MP0005394_taste/olfaction_phenotype2.96834866
14MP0005365_abnormal_bile_salt2.92852131
15MP0003705_abnormal_hypodermis_morpholog2.87991903
16MP0004147_increased_porphyrin_level2.85752320
17MP0004019_abnormal_vitamin_homeostasis2.71211110
18MP0002277_abnormal_respiratory_mucosa2.64152018
19MP0004957_abnormal_blastocyst_morpholog2.59491336
20MP0005075_abnormal_melanosome_morpholog2.51738345
21MP0008057_abnormal_DNA_replication2.49706548
22MP0009840_abnormal_foam_cell2.43791414
23MP0001664_abnormal_digestion2.42651232
24MP0003122_maternal_imprinting2.30640052
25MP0005257_abnormal_intraocular_pressure2.30415571
26MP0003183_abnormal_peptide_metabolism2.20128283
27MP0005409_darkened_coat_color2.14317239
28MP0002332_abnormal_exercise_endurance2.07299918
29MP0001348_abnormal_lacrimal_gland2.02882573
30MP0006035_abnormal_mitochondrial_morpho2.00625775
31MP0003283_abnormal_digestive_organ1.95912729
32MP0003868_abnormal_feces_composition1.93689345
33MP0001849_ear_inflammation1.88275910
34MP0003121_genomic_imprinting1.88251908
35MP0000678_abnormal_parathyroid_gland1.87507834
36MP0000490_abnormal_crypts_of1.86880972
37MP0001663_abnormal_digestive_system1.86198637
38MP0001765_abnormal_ion_homeostasis1.78275462
39MP0003123_paternal_imprinting1.76847232
40MP0005166_decreased_susceptibility_to1.75164477
41MP0006082_CNS_inflammation1.74226272
42MP0002653_abnormal_ependyma_morphology1.74195157
43MP0003938_abnormal_ear_development1.70846499
44MP0003315_abnormal_perineum_morphology1.64727189
45MP0005381_digestive/alimentary_phenotyp1.63685824
46MP0009643_abnormal_urine_homeostasis1.58595602
47MP0010030_abnormal_orbit_morphology1.54848030
48MP0000762_abnormal_tongue_morphology1.50877293
49MP0005380_embryogenesis_phenotype1.46821801
50MP0001672_abnormal_embryogenesis/_devel1.46821801
51MP0005636_abnormal_mineral_homeostasis1.43805662
52MP0004043_abnormal_pH_regulation1.43085122
53MP0002138_abnormal_hepatobiliary_system1.40656375
54MP0010329_abnormal_lipoprotein_level1.38325299
55MP0002088_abnormal_embryonic_growth/wei1.36420882
56MP0005332_abnormal_amino_acid1.36021787
57MP0000537_abnormal_urethra_morphology1.34789821
58MP0003984_embryonic_growth_retardation1.34230606
59MP0005451_abnormal_body_composition1.33950778
60MP0001188_hyperpigmentation1.33694689
61MP0003879_abnormal_hair_cell1.29036458
62MP0005670_abnormal_white_adipose1.28791727
63MP0008961_abnormal_basal_metabolism1.28030904
64MP0005266_abnormal_metabolism1.26533045
65MP0001764_abnormal_homeostasis1.20630698
66MP0003724_increased_susceptibility_to1.20180502
67MP0000049_abnormal_middle_ear1.19596974
68MP0010155_abnormal_intestine_physiology1.19134618
69MP0002127_abnormal_cardiovascular_syste1.18739995
70MP0000350_abnormal_cell_proliferation1.17625734
71MP0002136_abnormal_kidney_physiology1.17597031
72MP0003252_abnormal_bile_duct1.17429276
73MP0008004_abnormal_stomach_pH1.17244852
74MP0010234_abnormal_vibrissa_follicle1.16513234
75MP0005310_abnormal_salivary_gland1.15611018
76MP0000538_abnormal_urinary_bladder1.14405692
77MP0000477_abnormal_intestine_morphology1.14001838
78MP0000465_gastrointestinal_hemorrhage1.09207232
79MP0001873_stomach_inflammation1.07366736
80MP0008789_abnormal_olfactory_epithelium1.06099249
81MP0003119_abnormal_digestive_system1.05336818
82MP0002233_abnormal_nose_morphology1.05139251
83MP0002092_abnormal_eye_morphology1.03807642
84MP0001293_anophthalmia1.03096704
85MP0003303_peritoneal_inflammation1.01273044
86MP0002098_abnormal_vibrissa_morphology1.01117070
87* MP0002086_abnormal_extraembryonic_tissu1.00770635
88MP0001756_abnormal_urination1.00167204
89MP0008872_abnormal_physiological_respon0.99494405
90MP0002166_altered_tumor_susceptibility0.95341094
91MP0002085_abnormal_embryonic_tissue0.93661224
92MP0005248_abnormal_Harderian_gland0.93457827
93MP0000230_abnormal_systemic_arterial0.92628193
94MP0002118_abnormal_lipid_homeostasis0.92411057
95MP0003693_abnormal_embryo_hatching0.90514573
96MP0002796_impaired_skin_barrier0.90497529
97MP0005501_abnormal_skin_physiology0.90083263
98MP0003787_abnormal_imprinting0.90018913
99MP0001845_abnormal_inflammatory_respons0.89560622
100MP0002132_abnormal_respiratory_system0.88710114
101MP0002970_abnormal_white_adipose0.88450123
102MP0002396_abnormal_hematopoietic_system0.87686247
103MP0009785_altered_susceptibility_to0.87403728
104MP0002822_catalepsy0.86264950
105MP0003300_gastrointestinal_ulcer0.83632503
106MP0003077_abnormal_cell_cycle0.83597083
107MP0003137_abnormal_impulse_conducting0.83574123
108MP0000462_abnormal_digestive_system0.83412252
109MP0000432_abnormal_head_morphology0.82932652
110MP0000609_abnormal_liver_physiology0.81686509
111MP0005025_abnormal_response_to0.80264078
112MP0001485_abnormal_pinna_reflex0.80124758
113MP0005584_abnormal_enzyme/coenzyme_acti0.79909102
114* MP0002932_abnormal_joint_morphology0.79901246
115MP0003329_amyloid_beta_deposits0.77536652
116MP0003453_abnormal_keratinocyte_physiol0.75896640
117MP0003191_abnormal_cellular_cholesterol0.75767770
118MP0002896_abnormal_bone_mineralization0.75649005
119MP0000383_abnormal_hair_follicle0.75489740
120MP0001501_abnormal_sleep_pattern0.75437550
121MP0002971_abnormal_brown_adipose0.75191845
122* MP0002114_abnormal_axial_skeleton0.74703415
123MP0005058_abnormal_lysosome_morphology0.74663363
124MP0010678_abnormal_skin_adnexa0.73941970
125MP0000428_abnormal_craniofacial_morphol0.73866962
126MP0004947_skin_inflammation0.73336812
127MP0005448_abnormal_energy_balance0.73322941
128MP0009333_abnormal_splenocyte_physiolog0.72339195
129MP0009115_abnormal_fat_cell0.72084705
130MP0003755_abnormal_palate_morphology0.71994237
131MP0005666_abnormal_adipose_tissue0.71715884
132MP0002084_abnormal_developmental_patter0.71427497
133MP0000566_synostosis0.71072563
134MP0003436_decreased_susceptibility_to0.70376473
135MP0000313_abnormal_cell_death0.70376124
136MP0001790_abnormal_immune_system0.69982303
137MP0005387_immune_system_phenotype0.69982303
138MP0008770_decreased_survivor_rate0.68051646
139MP0002006_tumorigenesis0.67925038
140MP0000613_abnormal_salivary_gland0.67835322
141MP0001835_abnormal_antigen_presentation0.67119487
142MP0001730_embryonic_growth_arrest0.67029863
143MP0004381_abnormal_hair_follicle0.65881647
144MP0000377_abnormal_hair_follicle0.65851010
145MP0003935_abnormal_craniofacial_develop0.61589341
146MP0002009_preneoplasia0.61366457
147MP0005360_urolithiasis0.60775846
148MP0003866_abnormal_defecation0.60376002
149MP0005165_increased_susceptibility_to0.60247417
150MP0004782_abnormal_surfactant_physiolog0.59997775
151MP0002148_abnormal_hypersensitivity_rea0.59789634
152MP0003718_maternal_effect0.59667328
153MP0005023_abnormal_wound_healing0.59541413
154MP0003111_abnormal_nucleus_morphology0.59086022
155MP0001216_abnormal_epidermal_layer0.57308730
156MP0004133_heterotaxia0.56978265
157MP0001697_abnormal_embryo_size0.56797062
158MP0000604_amyloidosis0.56713889
159MP0004270_analgesia0.56660823
160MP0005319_abnormal_enzyme/_coenzyme0.56618732
161MP0004197_abnormal_fetal_growth/weight/0.56568278
162MP0008469_abnormal_protein_level0.56158229
163MP0002998_abnormal_bone_remodeling0.56061374
164MP0009642_abnormal_blood_homeostasis0.56061032
165MP0002876_abnormal_thyroid_physiology0.54835023
166MP0003806_abnormal_nucleotide_metabolis0.52975295
167MP0002751_abnormal_autonomic_nervous0.52880251
168MP0005391_vision/eye_phenotype0.52830051
169MP0002080_prenatal_lethality0.51660463
170MP0005376_homeostasis/metabolism_phenot0.51207129
171MP0002249_abnormal_larynx_morphology0.50910026
172MP0002925_abnormal_cardiovascular_devel0.50739317
173MP0002111_abnormal_tail_morphology0.50451717

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)8.12387599
2Bilateral microphthalmos (HP:0007633)7.55269151
3Hyperactive renin-angiotensin system (HP:0000841)6.13510022
4Hypochromic microcytic anemia (HP:0004840)5.97229610
5Multiple enchondromatosis (HP:0005701)5.59474800
6Metabolic alkalosis (HP:0200114)5.51542211
7Decreased circulating renin level (HP:0003351)5.45818582
8Hepatoblastoma (HP:0002884)5.40930588
9Abnormality of proline metabolism (HP:0010907)5.35586085
10Hydroxyprolinuria (HP:0003080)5.35586085
11Abnormality of renin-angiotensin system (HP:0000847)4.91829112
12Rib fusion (HP:0000902)4.51230448
13Alkalosis (HP:0001948)4.50369226
14Chronic diarrhea (HP:0002028)4.50083134
15Systemic lupus erythematosus (HP:0002725)4.40559740
16Abnormality of the vitamin B12 metabolism (HP:0004341)4.25551733
17Abnormality of the lower motor neuron (HP:0002366)4.16151831
18Ependymoma (HP:0002888)4.00131183
19Abnormality of vitamin B metabolism (HP:0004340)3.94596592
20Abnormality of monocarboxylic acid metabolism (HP:0010996)3.72953859
21Trismus (HP:0000211)3.70249172
22Flat acetabular roof (HP:0003180)3.69079947
23Fat malabsorption (HP:0002630)3.68846456
24Right ventricular cardiomyopathy (HP:0011663)3.63724999
25Widely patent fontanelles and sutures (HP:0004492)3.63132630
26Abdominal distention (HP:0003270)3.58148751
27Testicular atrophy (HP:0000029)3.52887639
28Partial duplication of thumb phalanx (HP:0009944)3.50732763
29Neoplasm of striated muscle (HP:0009728)3.39477920
30Ragged-red muscle fibers (HP:0003200)3.33860918
31Confusion (HP:0001289)3.33760060
32Nephroblastoma (Wilms tumor) (HP:0002667)3.32577179
33Rhabdomyosarcoma (HP:0002859)3.29914610
34Villous atrophy (HP:0011473)3.29733046
35Abnormality of small intestinal villus morphology (HP:0011472)3.29733046
36Abnormal cartilage morphology (HP:0002763)3.29467102
37Congenital sensorineural hearing impairment (HP:0008527)3.27131772
38Fused cervical vertebrae (HP:0002949)3.20462762
39Abnormality of vitamin metabolism (HP:0100508)3.18925713
40Hypobetalipoproteinemia (HP:0003563)3.18300928
41Hypoplasia of the fovea (HP:0007750)3.15913493
42Aplasia/Hypoplasia of the fovea (HP:0008060)3.15913493
43Hyperinsulinemic hypoglycemia (HP:0000825)3.15905188
44Reduced antithrombin III activity (HP:0001976)3.15426968
45Abnormality of the salivary glands (HP:0010286)3.12246967
46Malnutrition (HP:0004395)3.11810296
47Abnormality of chloride homeostasis (HP:0011422)3.08515920
48Hemorrhage of the eye (HP:0011885)3.08350102
49Rectal fistula (HP:0100590)3.07422910
50Rectovaginal fistula (HP:0000143)3.07422910
51Embryonal renal neoplasm (HP:0011794)3.05953378
52Short humerus (HP:0005792)3.04676748
53Aplasia/hypoplasia of the humerus (HP:0006507)3.03988873
54Partial duplication of the phalanx of hand (HP:0009999)3.03612467
55Chromosomal breakage induced by crosslinking agents (HP:0003221)3.01600477
56Thin bony cortex (HP:0002753)2.98871320
57Hyperaldosteronism (HP:0000859)2.94856786
58Proximal tubulopathy (HP:0000114)2.91727157
59Acanthocytosis (HP:0001927)2.87320341
60Hyperparathyroidism (HP:0000843)2.82850646
61Wide cranial sutures (HP:0010537)2.80701505
62Abnormality of the phalanges of the hallux (HP:0010057)2.80052316
63Abnormality of the distal phalanx of the thumb (HP:0009617)2.77561090
64Astrocytoma (HP:0009592)2.76383441
65Abnormality of the astrocytes (HP:0100707)2.76383441
66Hypokalemia (HP:0002900)2.74435994
67Cheilitis (HP:0100825)2.74140947
68Nausea (HP:0002018)2.73779434
69Intestinal fistula (HP:0100819)2.71905400
70Eczematoid dermatitis (HP:0000976)2.71109268
71Hyperglycinuria (HP:0003108)2.70228524
72Bifid tongue (HP:0010297)2.69167774
73Anomalous pulmonary venous return (HP:0010772)2.68631466
74Chromsome breakage (HP:0040012)2.67622888
75Abnormality of urine glucose concentration (HP:0011016)2.66911338
76Glycosuria (HP:0003076)2.66911338
77Vaginal fistula (HP:0004320)2.66710474
78Abnormal lung lobation (HP:0002101)2.64708776
79Pili torti (HP:0003777)2.63883421
80Periauricular skin pits (HP:0100277)2.62654150
81Preauricular pit (HP:0004467)2.62654150
82Tongue fasciculations (HP:0001308)2.61674714
83Sensory axonal neuropathy (HP:0003390)2.61220839
84Horizontal nystagmus (HP:0000666)2.60226379
85Amyotrophic lateral sclerosis (HP:0007354)2.59370333
86Abnormal tarsal ossification (HP:0008369)2.57918568
87Glomerulonephritis (HP:0000099)2.53822928
88Microretrognathia (HP:0000308)2.53534341
89Nephrolithiasis (HP:0000787)2.52641516
90Hyperammonemia (HP:0001987)2.52226302
91Preauricular skin tag (HP:0000384)2.51722335
92Large earlobe (HP:0009748)2.50642668
93Hypochromic anemia (HP:0001931)2.48837218
94Intrahepatic cholestasis (HP:0001406)2.45955287
95Upper limb muscle weakness (HP:0003484)2.44866243
96Pigmentary retinal degeneration (HP:0001146)2.44800167
97Abnormality of complement system (HP:0005339)2.43505160
98Progressive muscle weakness (HP:0003323)2.43446860
99Renal tubular acidosis (HP:0001947)2.39547297
100Hypophosphatemia (HP:0002148)2.38807599
101Shawl scrotum (HP:0000049)2.38393590
102Abnormality of serine family amino acid metabolism (HP:0010894)2.36913109
103Abnormality of glycine metabolism (HP:0010895)2.36913109
104Abnormality of potassium homeostasis (HP:0011042)2.36777415
105Xanthomatosis (HP:0000991)2.35883840
106Muscle fibrillation (HP:0010546)2.33399367
107Nasolacrimal duct obstruction (HP:0000579)2.33128913
108Abnormality of the pulmonary veins (HP:0011718)2.32607656
109Hypotension (HP:0002615)2.32269666
110Hyponatremia (HP:0002902)2.32013505
111Dicarboxylic aciduria (HP:0003215)2.31848899
112Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31848899
113Short 5th finger (HP:0009237)2.30181988
114Increased purine levels (HP:0004368)2.29297607
115Hyperuricemia (HP:0002149)2.29297607
116Aplastic anemia (HP:0001915)2.28767005
117Increased connective tissue (HP:0009025)2.28616976
118Abnormality of the fovea (HP:0000493)2.28257664
119Mildly elevated creatine phosphokinase (HP:0008180)2.27913676
120Delayed epiphyseal ossification (HP:0002663)2.27792535
121Complement deficiency (HP:0004431)2.26708597
122Pendular nystagmus (HP:0012043)2.24369240
123Impulsivity (HP:0100710)2.22593773
124Posterior subcapsular cataract (HP:0007787)2.21151011
125Micronodular cirrhosis (HP:0001413)2.20791202
126Conjugated hyperbilirubinemia (HP:0002908)2.19536167
127Hyperphosphatemia (HP:0002905)2.18309798
128Abnormal hair laboratory examination (HP:0003328)2.17621672
129Nephritis (HP:0000123)2.17619918
130Skin tags (HP:0010609)2.17398476
131Glossoptosis (HP:0000162)2.16958083
132Focal segmental glomerulosclerosis (HP:0000097)2.16939591
133Hyperventilation (HP:0002883)2.15334821
134Abnormal biliary tract morphology (HP:0012440)2.14766429
135Skin pits (HP:0100276)2.11434777
136Ileus (HP:0002595)2.10745440
137Tetraplegia (HP:0002445)2.09744868
138Flattened epiphyses (HP:0003071)2.08873200
139Megaloblastic anemia (HP:0001889)2.07690764
140Difficulty running (HP:0009046)2.07229194
141Meckel diverticulum (HP:0002245)2.07074499
142Abnormality of the pubic bones (HP:0003172)2.06900561
143Cerebral palsy (HP:0100021)2.06603691
144Steatorrhea (HP:0002570)2.06518489
145Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.06506477
146Growth hormone excess (HP:0000845)2.06287446
147Aplasia/Hypoplasia of the uvula (HP:0010293)2.05693826
148Syncope (HP:0001279)2.05503020
149Abnormality of magnesium homeostasis (HP:0004921)2.04682161
150Renal duplication (HP:0000075)2.04087685
151Abnormality of pyrimidine metabolism (HP:0004353)2.03844878
152Abnormality of the musculature of the hand (HP:0001421)2.03650975
153Supernumerary spleens (HP:0009799)2.00070806
154Combined immunodeficiency (HP:0005387)1.99026285
155Gastrointestinal dysmotility (HP:0002579)1.97985693
156Enlarged epiphyses (HP:0010580)1.97413738
157Neoplasm of the heart (HP:0100544)1.97387114
158Abnormality of nucleobase metabolism (HP:0010932)1.96435644
159Protuberant abdomen (HP:0001538)1.96324160
160Glioma (HP:0009733)1.96296233
161Generalized hypotonia (HP:0001290)1.96186067
162Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95926260
163Abnormality of the costochondral junction (HP:0000919)1.95598373
164Fasciculations (HP:0002380)1.95369752
165Aplasia/Hypoplasia of the macula (HP:0008059)1.94303648
166Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.93805066
167Visceral angiomatosis (HP:0100761)1.93753182
168Dehydration (HP:0001944)1.93343585
169Ventricular fibrillation (HP:0001663)1.93252697
170Hypoplastic scapulae (HP:0000882)1.93101427
171Aplasia/Hypoplasia of the scapulae (HP:0006713)1.93101427
172Abnormality of purine metabolism (HP:0004352)1.93039745
173Pancreatitis (HP:0001733)1.93016860
174Type I transferrin isoform profile (HP:0003642)1.92316218
175Biliary tract neoplasm (HP:0100574)1.90788459
176Abnormality of the ileum (HP:0001549)1.90740566
177Pseudobulbar signs (HP:0002200)1.90649875
178Petechiae (HP:0000967)1.90280423
179Abnormal urine phosphate concentration (HP:0012599)1.89879126
180Microvesicular hepatic steatosis (HP:0001414)1.89065603
181Metabolic acidosis (HP:0001942)1.88860326
182Symptomatic seizures (HP:0011145)1.88529797
183Angiofibromas (HP:0010615)1.88220999
184Adenoma sebaceum (HP:0009720)1.88220999
185Hyperphosphaturia (HP:0003109)1.87393420
186Abnormality of chromosome segregation (HP:0002916)1.87117934
187Abnormality of carpal bone ossification (HP:0006257)1.87075685
188Increased serum pyruvate (HP:0003542)1.86968166
189Abnormality of glycolysis (HP:0004366)1.86968166
190Ventricular tachycardia (HP:0004756)1.86952180
191Potter facies (HP:0002009)1.86818718
192Facial shape deformation (HP:0011334)1.86818718
193Neonatal short-limb short stature (HP:0008921)1.79626142
194Abnormality of the 1st metacarpal (HP:0010009)1.79230208
195Curly hair (HP:0002212)1.78891481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.40314187
2ACVR1B6.59051872
3GRK55.16336874
4ERN14.73538034
5GRK64.49667413
6GRK13.27010913
7PIK3CA3.08912994
8ADRBK22.86110180
9STK392.78162635
10TTK2.72274325
11MATK2.61958282
12CSF1R2.59693536
13TYRO32.51503543
14TGFBR22.32511370
15STK102.27579702
16GRK72.22007178
17PRKG22.21899384
18OXSR12.14428694
19MAPK72.03389902
20WNK11.87324578
21MOS1.83655943
22PTK61.82201077
23FGFR41.79919479
24EPHA21.69967173
25TESK21.68265870
26STK241.52318805
27NTRK11.45604662
28CDK71.44742260
29PAK41.41001072
30CAMK41.33828641
31MYLK1.32724437
32MAP2K61.29542117
33MAP3K121.27600729
34TYK21.26082539
35PDK21.25477277
36LMTK21.24349249
37TESK11.20349726
38PRPF4B1.20194547
39MAP3K21.18831413
40MST41.18820784
41MAP3K11.16157707
42MAP3K101.15121939
43AKT31.14915805
44EPHB11.14187897
45MAP4K11.14076646
46NME11.07780401
47WNK41.06861285
48CHEK21.03409954
49MAP3K71.02706106
50EPHA31.00309048
51ADRBK10.98864061
52FGFR30.98309324
53PLK10.94523955
54CDC42BPA0.93652880
55HIPK20.93375051
56RIPK40.89760173
57MARK20.89480821
58MAP2K20.86963773
59CSK0.86814685
60CDK190.85316554
61PDPK10.84225439
62MAP2K40.83693454
63PRKCI0.83395101
64SMG10.74326767
65LATS10.73164013
66RIPK10.71927393
67RPS6KB20.71395027
68AKT20.70515708
69TNIK0.69465536
70ERBB20.66692202
71MAPK110.66526874
72PTK20.66425158
73MST1R0.63917706
74MAP3K110.63177960
75ALK0.62985646
76FER0.61608912
77ABL20.61590313
78TRIB30.58962400
79EIF2AK20.58195482
80CHEK10.57104836
81EPHA40.56613212
82CAMK2D0.55241605
83NLK0.53298341
84KSR20.50530481
85PDK10.50360740
86PAK10.48937679
87DYRK1B0.47572993
88DDR20.44936364
89NEK20.44300214
90ZAP700.43501784
91PRKCA0.42641393
92RET0.42544564
93TBK10.42006251
94AURKB0.41565906
95ITK0.40514133
96MTOR0.38752013
97DMPK0.38672467
98MAPK120.38560618
99PRKCD0.38236942
100YES10.36579894
101DYRK30.36438790
102IGF1R0.34932886
103JAK20.33371892
104CSNK1E0.32819696
105LATS20.32782241
106PRKCZ0.32084804
107PDGFRA0.31233734
108RPS6KA20.30373473
109IKBKE0.30049631
110BMX0.29959079
111TAOK10.29697670
112FYN0.29221203
113CDK20.29204218
114MET0.28624291
115IKBKB0.27994870
116FRK0.27816714
117MAP3K90.25953680
118AURKA0.23942289
119PRKACG0.23529490
120CDK60.23174112
121CHUK0.23064031
122BUB10.22604948
123IRAK10.22212886
124CAMK2G0.22069128
125RPS6KC10.21958782
126RPS6KL10.21958782
127PIM10.21899323
128MAP2K10.21008118
129INSR0.20225501
130CSNK1A10.20190181
131MAP3K80.20039994
132CDK40.20038349
133PRKCQ0.19661738
134MAP3K140.19511160
135PRKAA10.19337526
136ATM0.19211865
137FGR0.19187313
138BMPR20.19133497
139NME20.19015126
140LYN0.18980777
141LRRK20.18577324
142MAPKAPK30.18300327
143JAK10.18254991
144GSK3A0.17509482
145NEK10.17471920
146PRKACB0.16365722
147ICK0.15032274
148BLK0.14391516
149PRKAA20.14159342
150GSK3B0.13687970
151EPHB20.12746468
152MAPKAPK20.12697263
153PAK30.12440900
154MAPK10.11896762
155STK38L0.11339064
156STK380.11337958
157MAPK140.10994035
158SRC0.10980017
159CDK10.10651223
160CDK150.09840730
161MAPK40.09816268
162MAPK100.09585256
163DYRK1A0.09528635
164PRKACA0.09389926

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.06262775
2Vitamin B6 metabolism_Homo sapiens_hsa007504.92455921
3Fructose and mannose metabolism_Homo sapiens_hsa000514.47291663
4Galactose metabolism_Homo sapiens_hsa000523.12881461
5Pentose and glucuronate interconversions_Homo sapiens_hsa000403.11478631
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07179695
7Arachidonic acid metabolism_Homo sapiens_hsa005903.02924793
8Linoleic acid metabolism_Homo sapiens_hsa005912.88031156
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.84565760
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.71387604
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.65849501
12Arginine biosynthesis_Homo sapiens_hsa002202.53596585
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.45612965
14Caffeine metabolism_Homo sapiens_hsa002322.34900048
15Thyroid cancer_Homo sapiens_hsa052161.72223214
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.69593813
17PPAR signaling pathway_Homo sapiens_hsa033201.66867741
18Nitrogen metabolism_Homo sapiens_hsa009101.54208687
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52202270
20Fatty acid degradation_Homo sapiens_hsa000711.46575731
21Chemical carcinogenesis_Homo sapiens_hsa052041.43025409
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.40070902
23Fat digestion and absorption_Homo sapiens_hsa049751.39058677
24Asthma_Homo sapiens_hsa053101.38067120
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36072132
26Tryptophan metabolism_Homo sapiens_hsa003801.35483983
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.30880869
28Ribosome_Homo sapiens_hsa030101.27866112
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.25309278
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22623908
31Ether lipid metabolism_Homo sapiens_hsa005651.19743236
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14991157
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13454239
34Pentose phosphate pathway_Homo sapiens_hsa000301.12232984
35Pancreatic secretion_Homo sapiens_hsa049721.11201612
36Folate biosynthesis_Homo sapiens_hsa007901.08930531
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08755387
38Sulfur metabolism_Homo sapiens_hsa009201.06884458
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04898084
40Histidine metabolism_Homo sapiens_hsa003401.01137668
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00505917
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00225976
43Mineral absorption_Homo sapiens_hsa049780.99621247
44Allograft rejection_Homo sapiens_hsa053300.96725303
45mTOR signaling pathway_Homo sapiens_hsa041500.94878898
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.93232936
47RNA transport_Homo sapiens_hsa030130.91445916
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.90952609
49Autoimmune thyroid disease_Homo sapiens_hsa053200.90692982
50Protein digestion and absorption_Homo sapiens_hsa049740.89130064
51Tight junction_Homo sapiens_hsa045300.88544839
52Other glycan degradation_Homo sapiens_hsa005110.87228615
53Graft-versus-host disease_Homo sapiens_hsa053320.85245443
54Staphylococcus aureus infection_Homo sapiens_hsa051500.84559551
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83480140
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.82346529
57African trypanosomiasis_Homo sapiens_hsa051430.79164095
58Inositol phosphate metabolism_Homo sapiens_hsa005620.77439264
59Carbon metabolism_Homo sapiens_hsa012000.76145861
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76135277
61Bile secretion_Homo sapiens_hsa049760.75666652
62Renin-angiotensin system_Homo sapiens_hsa046140.72993854
63Bladder cancer_Homo sapiens_hsa052190.72708369
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72383558
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72066135
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.69901107
67Glutathione metabolism_Homo sapiens_hsa004800.67980812
68Basal cell carcinoma_Homo sapiens_hsa052170.67238585
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.67069906
70Type I diabetes mellitus_Homo sapiens_hsa049400.64808158
71Phenylalanine metabolism_Homo sapiens_hsa003600.64783980
72Sulfur relay system_Homo sapiens_hsa041220.63656558
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63505834
74Ovarian steroidogenesis_Homo sapiens_hsa049130.61936242
75Fanconi anemia pathway_Homo sapiens_hsa034600.60226276
76Glycerolipid metabolism_Homo sapiens_hsa005610.60043666
77Starch and sucrose metabolism_Homo sapiens_hsa005000.59614481
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58663931
79Choline metabolism in cancer_Homo sapiens_hsa052310.55790268
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55665171
81Fatty acid metabolism_Homo sapiens_hsa012120.54861106
82mRNA surveillance pathway_Homo sapiens_hsa030150.53630420
83One carbon pool by folate_Homo sapiens_hsa006700.53413123
84Pathways in cancer_Homo sapiens_hsa052000.52741950
85Sphingolipid metabolism_Homo sapiens_hsa006000.52018429
86Homologous recombination_Homo sapiens_hsa034400.51358473
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.51162593
88Retinol metabolism_Homo sapiens_hsa008300.50389384
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49148536
90Antigen processing and presentation_Homo sapiens_hsa046120.49053550
91DNA replication_Homo sapiens_hsa030300.48514246
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48081968
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46692195
94Mismatch repair_Homo sapiens_hsa034300.46457668
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46101384
96Cell cycle_Homo sapiens_hsa041100.45932273
97p53 signaling pathway_Homo sapiens_hsa041150.45624204
98Peroxisome_Homo sapiens_hsa041460.43214440
99Rap1 signaling pathway_Homo sapiens_hsa040150.43028177
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.41411834
101Renin secretion_Homo sapiens_hsa049240.41356074
102Hippo signaling pathway_Homo sapiens_hsa043900.41307693
103Biosynthesis of amino acids_Homo sapiens_hsa012300.41023698
104Leishmaniasis_Homo sapiens_hsa051400.39476922
105Adherens junction_Homo sapiens_hsa045200.39091284
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38426730
107Arginine and proline metabolism_Homo sapiens_hsa003300.38241370
108MicroRNAs in cancer_Homo sapiens_hsa052060.37380485
109Metabolic pathways_Homo sapiens_hsa011000.36177073
110Tyrosine metabolism_Homo sapiens_hsa003500.35985163
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35965619
112Thyroid hormone synthesis_Homo sapiens_hsa049180.35922569
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35403709
114Pertussis_Homo sapiens_hsa051330.34675424
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33339698
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33153222
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32370608
118Apoptosis_Homo sapiens_hsa042100.32343576
119Acute myeloid leukemia_Homo sapiens_hsa052210.30758459
120Hedgehog signaling pathway_Homo sapiens_hsa043400.30579202
121Viral myocarditis_Homo sapiens_hsa054160.29585010
122RNA degradation_Homo sapiens_hsa030180.29582517
123Hepatitis C_Homo sapiens_hsa051600.28047956
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27861974
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.26512283
126VEGF signaling pathway_Homo sapiens_hsa043700.26442580
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24268448
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23992741
129Insulin resistance_Homo sapiens_hsa049310.23928812
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21822519
131Vitamin digestion and absorption_Homo sapiens_hsa049770.20390986
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.20386280
133Pyruvate metabolism_Homo sapiens_hsa006200.19460328
134Fatty acid biosynthesis_Homo sapiens_hsa000610.19327669
135Butanoate metabolism_Homo sapiens_hsa006500.19178412
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.17299534
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16515572
138Toxoplasmosis_Homo sapiens_hsa051450.15665958
139Vibrio cholerae infection_Homo sapiens_hsa051100.10241180
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09525261
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.08470025
142Influenza A_Homo sapiens_hsa051640.08029187
143Propanoate metabolism_Homo sapiens_hsa006400.07715757
144Salmonella infection_Homo sapiens_hsa051320.06829267
145Hematopoietic cell lineage_Homo sapiens_hsa046400.05664276
146Tuberculosis_Homo sapiens_hsa051520.05236232
147Chemokine signaling pathway_Homo sapiens_hsa040620.04382203
148Fatty acid elongation_Homo sapiens_hsa000620.03274626
149GnRH signaling pathway_Homo sapiens_hsa049120.03105674
150Amoebiasis_Homo sapiens_hsa051460.02271104

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