CDX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a small subfamily of homeobox containing transcription factors. The encoded protein may regulate homeobox gene expression during anteroposterior patterning and hematopoiesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)8.44966968
2transcription from mitochondrial promoter (GO:0006390)8.13500148
3embryonic process involved in female pregnancy (GO:0060136)7.52454498
4replication fork processing (GO:0031297)7.40002015
5establishment of apical/basal cell polarity (GO:0035089)6.87591836
6positive regulation of protein homooligomerization (GO:0032464)6.84194341
7chaperone-mediated protein transport (GO:0072321)6.44080703
8oxidative demethylation (GO:0070989)6.43165171
9proteasome assembly (GO:0043248)6.41153977
10regulation of integrin activation (GO:0033623)5.99667780
11establishment of monopolar cell polarity (GO:0061162)5.97591983
12establishment or maintenance of monopolar cell polarity (GO:0061339)5.97591983
13maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.93555860
14regulation of protein homooligomerization (GO:0032462)5.80164152
15DNA deamination (GO:0045006)5.74096086
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)5.66107850
17DNA strand renaturation (GO:0000733)5.40391603
18mitochondrial DNA metabolic process (GO:0032042)5.26624109
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)5.20693375
20negative regulation of ligase activity (GO:0051352)5.20693375
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)5.19659436
22regulation of cellular amino acid metabolic process (GO:0006521)5.18369204
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.16598553
24negative regulation of JAK-STAT cascade (GO:0046426)5.16555491
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)5.15046557
26poly(A)+ mRNA export from nucleus (GO:0016973)5.14197288
27somatic hypermutation of immunoglobulin genes (GO:0016446)5.05327697
28somatic diversification of immune receptors via somatic mutation (GO:0002566)5.05327697
29establishment of integrated proviral latency (GO:0075713)4.93261313
30regulation of mitochondrial translation (GO:0070129)4.89864871
31cellular response to ATP (GO:0071318)4.87348055
32DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.86571273
33viral mRNA export from host cell nucleus (GO:0046784)4.81792209
34intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.80875676
35signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.80875676
36anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.79289752
37signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.76974022
38signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.76974022
39signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.76974022
40ribosome assembly (GO:0042255)4.67121045
41mitotic G1 DNA damage checkpoint (GO:0031571)4.63070937
42signal transduction involved in DNA integrity checkpoint (GO:0072401)4.61753608
43signal transduction involved in DNA damage checkpoint (GO:0072422)4.61753608
44mRNA cleavage (GO:0006379)4.57288263
45convergent extension (GO:0060026)4.56825339
46signal transduction involved in cell cycle checkpoint (GO:0072395)4.55154993
47glutamine family amino acid biosynthetic process (GO:0009084)4.54535103
48negative regulation of cell cycle arrest (GO:0071157)4.51937255
49embryonic placenta development (GO:0001892)4.48943610
50termination of RNA polymerase III transcription (GO:0006386)4.48694624
51transcription elongation from RNA polymerase III promoter (GO:0006385)4.48694624
52negative regulation of Ras GTPase activity (GO:0034261)4.42228472
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.41538177
54negative regulation of fatty acid biosynthetic process (GO:0045717)4.41031727
55regulation of translational fidelity (GO:0006450)4.40067080
56positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.30882713
57energy coupled proton transport, down electrochemical gradient (GO:0015985)4.25453553
58ATP synthesis coupled proton transport (GO:0015986)4.25453553
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.20144736
60cell fate commitment involved in formation of primary germ layer (GO:0060795)4.19641831
61G1 DNA damage checkpoint (GO:0044783)4.17128963
62DNA integration (GO:0015074)4.15447840
63positive regulation of ligase activity (GO:0051351)4.13303297
64spliceosomal snRNP assembly (GO:0000387)4.11888867
65protein neddylation (GO:0045116)4.09472633
66mitotic G1/S transition checkpoint (GO:0044819)4.09212599
67face development (GO:0060324)4.06546994
68establishment of protein localization to mitochondrial membrane (GO:0090151)4.06514944
69positive regulation by host of viral transcription (GO:0043923)4.06194296
70spliceosomal tri-snRNP complex assembly (GO:0000244)4.05226625
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.02344328
72regulation of ubiquitin-protein transferase activity (GO:0051438)4.00599264
73establishment of viral latency (GO:0019043)4.00126172
74base-excision repair (GO:0006284)4.00058646
75respiratory electron transport chain (GO:0022904)3.98408174
76formation of translation preinitiation complex (GO:0001731)3.97579621
77pre-miRNA processing (GO:0031054)3.96812850
78cellular response to zinc ion (GO:0071294)3.96776865
79dosage compensation (GO:0007549)3.91398580
80positive regulation of developmental pigmentation (GO:0048087)3.90831238
81regulation of cellular amine metabolic process (GO:0033238)3.88097420
82DNA strand elongation involved in DNA replication (GO:0006271)3.87245315
83regulation of ligase activity (GO:0051340)3.87063660
84electron transport chain (GO:0022900)3.86212947
85respiratory chain complex IV assembly (GO:0008535)3.85688214
86negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.85556179
87positive regulation of protein oligomerization (GO:0032461)3.80328388
88protein maturation by protein folding (GO:0022417)3.79030154
89protein targeting to mitochondrion (GO:0006626)3.78944408
90chromatin remodeling at centromere (GO:0031055)3.76459179
91negative regulation of mRNA processing (GO:0050686)3.73853782
92antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.71990523
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.71235746
94regulation of RNA export from nucleus (GO:0046831)3.69482986
95histone H4-K12 acetylation (GO:0043983)3.68708673
96DNA double-strand break processing (GO:0000729)3.68677319
97DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.64915414
98embryonic camera-type eye development (GO:0031076)3.64156145
99positive regulation of cell cycle arrest (GO:0071158)3.63784019
100CENP-A containing nucleosome assembly (GO:0034080)3.63649007
101DNA damage response, detection of DNA damage (GO:0042769)3.63132851
102negative regulation of protein oligomerization (GO:0032460)3.62756809
103nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.60755390
104non-recombinational repair (GO:0000726)3.60297647
105double-strand break repair via nonhomologous end joining (GO:0006303)3.60297647
106DNA strand elongation (GO:0022616)3.60243866
107protein complex biogenesis (GO:0070271)3.59811061
108mitochondrial respiratory chain complex assembly (GO:0033108)3.58548866
109regulation of sister chromatid cohesion (GO:0007063)3.58263745
110IMP biosynthetic process (GO:0006188)3.58140688
1117-methylguanosine mRNA capping (GO:0006370)3.57776949
112inner mitochondrial membrane organization (GO:0007007)3.55819521
113regulation of helicase activity (GO:0051095)3.54892051
114mitotic metaphase plate congression (GO:0007080)3.53376307
115base-excision repair, AP site formation (GO:0006285)3.53133372
116regulation of protein oligomerization (GO:0032459)3.52543429
117negative regulation of protein ubiquitination (GO:0031397)3.51638608
118glial cell migration (GO:0008347)3.50696768
119RNA capping (GO:0036260)3.49118900
1207-methylguanosine RNA capping (GO:0009452)3.49118900
121GDP-mannose metabolic process (GO:0019673)3.48624712
122positive regulation of mitotic sister chromatid separation (GO:1901970)3.48399569
123positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.48399569
124positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.48399569
125termination of RNA polymerase II transcription (GO:0006369)3.46816745
126trophectodermal cell differentiation (GO:0001829)3.46140931
127proximal/distal pattern formation (GO:0009954)3.45964213
128DNA topological change (GO:0006265)3.44670387
129transcription-coupled nucleotide-excision repair (GO:0006283)3.44465972
130cullin deneddylation (GO:0010388)3.44378402
131telomere maintenance via semi-conservative replication (GO:0032201)3.43460547
132protein targeting to lysosome (GO:0006622)3.43173705
133establishment of protein localization to vacuole (GO:0072666)3.43173705
134protein targeting to vacuole (GO:0006623)3.43173705
135positive regulation of DNA repair (GO:0045739)3.42427708
136establishment of protein localization to mitochondrion (GO:0072655)3.42081108
137regulation of posttranscriptional gene silencing (GO:0060147)3.41812927
138regulation of gene silencing by miRNA (GO:0060964)3.41812927
139regulation of gene silencing by RNA (GO:0060966)3.41812927
140anatomical structure regression (GO:0060033)3.41386302
141protein localization to mitochondrion (GO:0070585)3.41021599
142mitochondrial respiratory chain complex I assembly (GO:0032981)3.38715716
143NADH dehydrogenase complex assembly (GO:0010257)3.38715716
144mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38715716
145regulation of translational termination (GO:0006449)3.38165810
146mitochondrial RNA metabolic process (GO:0000959)3.35839181
147negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.35309450
148regulation of cAMP-dependent protein kinase activity (GO:2000479)3.33852744
149negative regulation of heart rate (GO:0010459)3.33729727
150pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.33285238
151protein deneddylation (GO:0000338)3.33047986
152anterior/posterior axis specification, embryo (GO:0008595)3.32465475
153G1/S transition of mitotic cell cycle (GO:0000082)3.32030116
154cell cycle G1/S phase transition (GO:0044843)3.32030116
155regulation of podosome assembly (GO:0071801)3.31529454
156negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.31142195
157nucleotide-excision repair, DNA gap filling (GO:0006297)3.29080259
158regulation of double-strand break repair (GO:2000779)3.27561518
159apoptotic process involved in morphogenesis (GO:0060561)3.25771891
160meiotic chromosome segregation (GO:0045132)3.25756006
161spliceosomal complex assembly (GO:0000245)3.25713361
162sulfur amino acid catabolic process (GO:0000098)3.24593699
163signal transduction in response to DNA damage (GO:0042770)3.23397164
164pyrimidine nucleotide catabolic process (GO:0006244)3.23038005
165regulation of cell size (GO:0008361)3.22575760
166DNA demethylation (GO:0080111)3.19469882
167negative regulation of RNA splicing (GO:0033119)3.18922347
168purine nucleobase biosynthetic process (GO:0009113)3.18839330
169alkaloid metabolic process (GO:0009820)3.18771103
170protein-cofactor linkage (GO:0018065)3.18100437
171protein localization to kinetochore (GO:0034501)3.16757239
172regulation of double-strand break repair via homologous recombination (GO:0010569)3.16239256
173negative regulation of cell cycle G1/S phase transition (GO:1902807)3.15499482
174negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)3.15499482
175cytochrome complex assembly (GO:0017004)3.14026480
176positive regulation of SMAD protein import into nucleus (GO:0060391)3.12863363
177DNA ligation (GO:0006266)3.10110245
178positive regulation of hair follicle development (GO:0051798)3.10009957
179positive regulation of hair cycle (GO:0042635)3.10009957
180IMP metabolic process (GO:0046040)3.09921696
181nodal signaling pathway (GO:0038092)3.07434881
182regulation of cell cycle arrest (GO:0071156)3.05753527
183pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.04956724
184activation of Rac GTPase activity (GO:0032863)3.04855285
185histone exchange (GO:0043486)3.04484782
186telomere maintenance via recombination (GO:0000722)3.04429204
187maturation of 5.8S rRNA (GO:0000460)3.04135721
188negative regulation of appetite (GO:0032099)3.03278874
189negative regulation of response to food (GO:0032096)3.03278874
190regulation of DNA damage checkpoint (GO:2000001)3.01496145
191regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.99161773
192positive regulation of circadian rhythm (GO:0042753)2.98856224
193proline biosynthetic process (GO:0006561)11.0408316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.39371670
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.34927237
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.81220295
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.81220295
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.81220295
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.73031182
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.58312199
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.57942200
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43573504
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.41262558
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.22587512
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.20368643
13ETS1_20019798_ChIP-Seq_JURKAT_Human3.16436160
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.02590267
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.89373038
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.79626503
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.77700543
18* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.59120763
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54661105
20NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.50373402
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46867306
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42348997
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.41324252
24POU5F1_16518401_ChIP-PET_MESCs_Mouse2.40881264
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40464757
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.27584473
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.26983311
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25350478
29VDR_21846776_ChIP-Seq_THP-1_Human2.21577735
30FOXP3_21729870_ChIP-Seq_TREG_Human2.20073292
31* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.19558897
32KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.16510304
33ELK1_19687146_ChIP-ChIP_HELA_Human2.15907112
34VDR_23849224_ChIP-Seq_CD4+_Human2.12269652
35DCP1A_22483619_ChIP-Seq_HELA_Human2.10617177
36ERG_21242973_ChIP-ChIP_JURKAT_Human2.10139813
37LXR_22292898_ChIP-Seq_THP-1_Human2.06007304
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.03444695
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.94780095
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.93078772
41GABP_19822575_ChIP-Seq_HepG2_Human1.92774822
42NANOG_21062744_ChIP-ChIP_HESCs_Human1.92257837
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91261100
44* NANOG_16153702_ChIP-ChIP_HESCs_Human1.90285467
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.89260790
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.89070509
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87640035
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85406582
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84891055
50* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.81364562
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79245761
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.78979669
53XRN2_22483619_ChIP-Seq_HELA_Human1.77872307
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76561680
55E2F7_22180533_ChIP-Seq_HELA_Human1.75044748
56PU.1_20513432_ChIP-Seq_Bcells_Mouse1.74620610
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.74041801
58* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.71870464
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71482208
60AR_21909140_ChIP-Seq_LNCAP_Human1.70734928
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69139529
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67589214
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65022061
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.62774637
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.62340153
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.62216219
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61192876
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60985462
69TTF2_22483619_ChIP-Seq_HELA_Human1.55636860
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55010801
71* SOX2_16153702_ChIP-ChIP_HESCs_Human1.54060714
72FOXM1_23109430_ChIP-Seq_U2OS_Human1.50528609
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.49831306
74MYC_22102868_ChIP-Seq_BL_Human1.49787369
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49305849
76RACK7_27058665_Chip-Seq_MCF-7_Human1.48209683
77NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.45722948
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45686167
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45605534
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.44011830
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43791206
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43275506
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42762981
84* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.41821493
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.41686581
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40335428
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37779898
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36973950
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36093526
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33904477
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31530199
92RXRA_24833708_ChIP-Seq_LIVER_Mouse1.31395040
93* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.31281179
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29178761
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28935442
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27531491
97* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.27494572
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27421124
99RARB_24833708_ChIP-Seq_LIVER_Mouse1.27352073
100ETS1_21867929_ChIP-Seq_TH2_Mouse1.26609361
101FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26236108
102ZNF263_19887448_ChIP-Seq_K562_Human1.24992456
103E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24014137
104SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21973687
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21867469
106MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21473246
107* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.21199871
108* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19762571
109KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19659492
110SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19618125
111KDM2B_26808549_Chip-Seq_DND41_Human1.18083189
112TP53_20018659_ChIP-ChIP_R1E_Mouse1.17870942
113ELK1_22589737_ChIP-Seq_MCF10A_Human1.17754782
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17688071
115* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.17436303
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17409353
117* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17027745
118SPI1_26923725_Chip-Seq_HPCs_Mouse1.16496786
119THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16206772
120RARA_24833708_ChIP-Seq_LIVER_Mouse1.13192646
121* NANOG_16518401_ChIP-PET_MESCs_Mouse1.12844651
122CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11624382
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.10961126
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10693083
125RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10657585
126* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10044312
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09743228
128KDM5A_27292631_Chip-Seq_BREAST_Human1.09004817
129SALL1_21062744_ChIP-ChIP_HESCs_Human1.08464446
130PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08076438
131TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07785785
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07008803
133JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06980958
134P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06647308
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05687805
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05633554
137MYC_18940864_ChIP-ChIP_HL60_Human1.05458769
138CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05090570
139SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03506009
140ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03488930
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02786040
142CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02542270
143CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01594135
144SOX17_20123909_ChIP-Seq_XEN_Mouse1.01348579
145ELK3_25401928_ChIP-Seq_HUVEC_Human1.00861924
146PHF8_20622854_ChIP-Seq_HELA_Human1.00387154
147KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99215828
148TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98897022
149TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97606004
150STAT1_20625510_ChIP-Seq_HELA_Human0.97363972
151CDX2_20551321_ChIP-Seq_CACO-2_Human0.97363712
152KAP1_27257070_Chip-Seq_ESCs_Mouse0.96666056
153STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96066304
154CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95694503
155ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95004749
156BCOR_27268052_Chip-Seq_Bcells_Human0.94939206
157SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94575743
158EOMES_21245162_ChIP-Seq_HESCs_Human0.91325707
159KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90463230
160* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.87919964
161CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85121083
162ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84687448
163E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84285868
164VDR_22108803_ChIP-Seq_LS180_Human0.82805152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.95519012
2MP0005171_absent_coat_pigmentation4.69005899
3MP0004233_abnormal_muscle_weight4.20369496
4MP0009278_abnormal_bone_marrow4.20215129
5MP0010030_abnormal_orbit_morphology4.19898327
6MP0002163_abnormal_gland_morphology3.49796651
7MP0003283_abnormal_digestive_organ3.11639817
8MP0002009_preneoplasia2.98782203
9MP0003890_abnormal_embryonic-extraembry2.81997473
10MP0002102_abnormal_ear_morphology2.65719662
11MP0003806_abnormal_nucleotide_metabolis2.50752677
12MP0004858_abnormal_nervous_system2.45147435
13MP0002254_reproductive_system_inflammat2.41566690
14MP0003119_abnormal_digestive_system2.40323515
15MP0003186_abnormal_redox_activity2.39530116
16MP0005379_endocrine/exocrine_gland_phen2.32224697
17MP0006292_abnormal_olfactory_placode2.26812504
18MP0008995_early_reproductive_senescence2.24897915
19MP0006054_spinal_hemorrhage2.15932716
20MP0006072_abnormal_retinal_apoptosis2.15053746
21MP0002249_abnormal_larynx_morphology2.12176038
22MP0004133_heterotaxia2.10162412
23MP0008789_abnormal_olfactory_epithelium2.03778677
24MP0002653_abnormal_ependyma_morphology2.01044688
25MP0005646_abnormal_pituitary_gland2.00968111
26MP0010094_abnormal_chromosome_stability1.98186701
27MP0002282_abnormal_trachea_morphology1.85858410
28MP0005076_abnormal_cell_differentiation1.83386955
29MP0006035_abnormal_mitochondrial_morpho1.82262249
30MP0001545_abnormal_hematopoietic_system1.79893691
31MP0005397_hematopoietic_system_phenotyp1.79893691
32MP0004957_abnormal_blastocyst_morpholog1.79408187
33MP0003172_abnormal_lysosome_physiology1.75054922
34MP0001293_anophthalmia1.74063318
35MP0008007_abnormal_cellular_replicative1.69146552
36MP0002084_abnormal_developmental_patter1.68981088
37MP0010352_gastrointestinal_tract_polyps1.67354367
38MP0005174_abnormal_tail_pigmentation1.62896102
39MP0002736_abnormal_nociception_after1.60467598
40MP0004197_abnormal_fetal_growth/weight/1.60456558
41MP0004147_increased_porphyrin_level1.60149091
42MP0003786_premature_aging1.59984023
43MP0000579_abnormal_nail_morphology1.59134509
44MP0003453_abnormal_keratinocyte_physiol1.58141874
45MP0008058_abnormal_DNA_repair1.56135795
46MP0000372_irregular_coat_pigmentation1.55129292
47MP0002085_abnormal_embryonic_tissue1.54299086
48* MP0002086_abnormal_extraembryonic_tissu1.54008981
49MP0001727_abnormal_embryo_implantation1.52321105
50MP0005647_abnormal_sex_gland1.52116571
51MP0000462_abnormal_digestive_system1.51819117
52MP0005058_abnormal_lysosome_morphology1.51426979
53MP0002932_abnormal_joint_morphology1.50860570
54MP0009672_abnormal_birth_weight1.49105797
55MP0008932_abnormal_embryonic_tissue1.48239403
56MP0005394_taste/olfaction_phenotype1.46834335
57MP0005499_abnormal_olfactory_system1.46834335
58MP0008877_abnormal_DNA_methylation1.45996397
59MP0002111_abnormal_tail_morphology1.45326185
60MP0001697_abnormal_embryo_size1.45176313
61MP0009053_abnormal_anal_canal1.43920141
62MP0003121_genomic_imprinting1.43874655
63MP0003567_abnormal_fetal_cardiomyocyte1.40893973
64MP0003123_paternal_imprinting1.38384876
65MP0000537_abnormal_urethra_morphology1.37454443
66MP0000639_abnormal_adrenal_gland1.37373469
67MP0006036_abnormal_mitochondrial_physio1.35362684
68MP0003011_delayed_dark_adaptation1.33325355
69MP0003111_abnormal_nucleus_morphology1.31743691
70MP0003195_calcinosis1.31036653
71MP0005085_abnormal_gallbladder_physiolo1.30946758
72MP0001529_abnormal_vocalization1.30561755
73MP0002090_abnormal_vision1.29967251
74MP0002269_muscular_atrophy1.29765806
75MP0005380_embryogenesis_phenotype1.28706547
76MP0001672_abnormal_embryogenesis/_devel1.28706547
77MP0000371_diluted_coat_color1.28216615
78MP0001340_abnormal_eyelid_morphology1.26698073
79MP0000015_abnormal_ear_pigmentation1.23524088
80MP0003937_abnormal_limbs/digits/tail_de1.21937894
81MP0005075_abnormal_melanosome_morpholog1.21861605
82MP0000470_abnormal_stomach_morphology1.20349451
83MP0005670_abnormal_white_adipose1.19661938
84MP0004264_abnormal_extraembryonic_tissu1.19433646
85MP0005365_abnormal_bile_salt1.18312291
86MP0000762_abnormal_tongue_morphology1.16694629
87MP0002697_abnormal_eye_size1.13206101
88MP0000490_abnormal_crypts_of1.07530612
89* MP0002114_abnormal_axial_skeleton1.03153902
90MP0004215_abnormal_myocardial_fiber1.03060256
91MP0003935_abnormal_craniofacial_develop1.02552299
92MP0001881_abnormal_mammary_gland1.01873732
93MP0003755_abnormal_palate_morphology1.01724012
94MP0005645_abnormal_hypothalamus_physiol1.00796882
95MP0002796_impaired_skin_barrier1.00248203
96MP0002116_abnormal_craniofacial_bone1.00015336
97MP0000350_abnormal_cell_proliferation0.97826825
98MP0000428_abnormal_craniofacial_morphol0.97749295
99MP0002233_abnormal_nose_morphology0.97451045
100MP0001849_ear_inflammation0.97229760
101MP0006082_CNS_inflammation0.97142944
102MP0001730_embryonic_growth_arrest0.96589797
103MP0003077_abnormal_cell_cycle0.94825326
104MP0003984_embryonic_growth_retardation0.92648778
105MP0003385_abnormal_body_wall0.90920852
106MP0002080_prenatal_lethality0.89704417
107MP0003646_muscle_fatigue0.89595797
108MP0002088_abnormal_embryonic_growth/wei0.88904472
109MP0003693_abnormal_embryo_hatching0.87056170
110MP0000049_abnormal_middle_ear0.86608841
111MP0008961_abnormal_basal_metabolism0.86594524
112MP0001324_abnormal_eye_pigmentation0.86109783
113MP0005395_other_phenotype0.84727596
114MP0000313_abnormal_cell_death0.84615463
115MP0005367_renal/urinary_system_phenotyp0.84102637
116MP0000516_abnormal_urinary_system0.84102637
117MP0001853_heart_inflammation0.84004677
118MP0002075_abnormal_coat/hair_pigmentati0.83931530
119MP0000467_abnormal_esophagus_morphology0.82409816
120MP0000432_abnormal_head_morphology0.82396555
121MP0003137_abnormal_impulse_conducting0.81546636
122MP0005253_abnormal_eye_physiology0.80343140
123MP0009115_abnormal_fat_cell0.80275196
124MP0009697_abnormal_copulation0.78841408
125MP0005266_abnormal_metabolism0.78536313
126MP0000358_abnormal_cell_content/0.76598229
127MP0005248_abnormal_Harderian_gland0.75959558
128MP0003828_pulmonary_edema0.74938662
129MP0005508_abnormal_skeleton_morphology0.74745580
130MP0001186_pigmentation_phenotype0.73538421
131MP0002019_abnormal_tumor_incidence0.71415900
132MP0003122_maternal_imprinting0.71196345
133MP0000751_myopathy0.71157555
134MP0009703_decreased_birth_body0.70212635
135MP0005501_abnormal_skin_physiology0.69930315
136MP0005391_vision/eye_phenotype0.69039410
137MP0001485_abnormal_pinna_reflex0.68701318
138MP0003942_abnormal_urinary_system0.68609891
139MP0002210_abnormal_sex_determination0.68125845
140MP0002060_abnormal_skin_morphology0.66839200
141MP0002160_abnormal_reproductive_system0.65512321
142MP0001177_atelectasis0.65500165
143MP0002837_dystrophic_cardiac_calcinosis0.65462399
144MP0001968_abnormal_touch/_nociception0.65373912
145MP0000955_abnormal_spinal_cord0.65319991
146MP0005330_cardiomyopathy0.64566483
147MP0004019_abnormal_vitamin_homeostasis0.64390858
148MP0000678_abnormal_parathyroid_gland0.63095650
149MP0003718_maternal_effect0.62873812
150MP0001119_abnormal_female_reproductive0.62067552
151MP0000653_abnormal_sex_gland0.62037070
152MP0003045_fibrosis0.59780718
153MP0001145_abnormal_male_reproductive0.59747608
154MP0003936_abnormal_reproductive_system0.59693187
155MP0003941_abnormal_skin_development0.58194067
156MP0001286_abnormal_eye_development0.57918056
157MP0002108_abnormal_muscle_morphology0.57906696
158MP0004142_abnormal_muscle_tone0.56313413
159MP0005503_abnormal_tendon_morphology0.55175252
160MP0000631_abnormal_neuroendocrine_gland0.54915091
161MP0010234_abnormal_vibrissa_follicle0.54218730

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)6.14013212
2Acute necrotizing encephalopathy (HP:0006965)5.95694300
3Abnormal mitochondria in muscle tissue (HP:0008316)5.46619488
4Rectal fistula (HP:0100590)5.23525708
5Rectovaginal fistula (HP:0000143)5.23525708
6Concave nail (HP:0001598)5.11486669
7Acute encephalopathy (HP:0006846)5.03358023
8Hypochromic microcytic anemia (HP:0004840)4.93804304
9Progressive macrocephaly (HP:0004481)4.88970511
10Annular pancreas (HP:0001734)4.88373081
11Turricephaly (HP:0000262)4.80437156
12Facial hemangioma (HP:0000329)4.80436527
13Vaginal fistula (HP:0004320)4.73019643
14Intestinal fistula (HP:0100819)4.71098489
15Mitochondrial inheritance (HP:0001427)4.48834671
16Increased IgM level (HP:0003496)4.34609925
17Increased CSF lactate (HP:0002490)4.33219531
18Pustule (HP:0200039)4.31718114
19Ulnar bowing (HP:0003031)4.27981780
20Intestinal atresia (HP:0011100)4.20994341
21Alopecia of scalp (HP:0002293)4.19412955
22Coronal craniosynostosis (HP:0004440)3.97453624
23Multiple enchondromatosis (HP:0005701)3.88902180
24Orthostatic hypotension (HP:0001278)3.85148412
25Poikiloderma (HP:0001029)3.84887762
26Short humerus (HP:0005792)3.77479986
27Abdominal situs inversus (HP:0003363)3.76932922
28Abnormality of abdominal situs (HP:0011620)3.76932922
29Cerebral edema (HP:0002181)3.76301935
30Fused cervical vertebrae (HP:0002949)3.73758651
31Tongue fasciculations (HP:0001308)3.73084346
32Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.66766084
33Hepatocellular necrosis (HP:0001404)3.65620281
34Aplasia/hypoplasia of the humerus (HP:0006507)3.62930856
35Microvesicular hepatic steatosis (HP:0001414)3.59974642
36Urinary glycosaminoglycan excretion (HP:0003541)3.59536258
37Mucopolysacchariduria (HP:0008155)3.59536258
38Male infertility (HP:0003251)3.56988243
39Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.48533121
40Vertebral hypoplasia (HP:0008417)3.48533121
41Abnormal hemoglobin (HP:0011902)3.48348451
42Anteriorly placed anus (HP:0001545)3.47743470
43Muscle fibrillation (HP:0010546)3.41576398
44Pancreatic islet-cell hyperplasia (HP:0004510)3.41393719
45Leukodystrophy (HP:0002415)3.33920221
46Dysostosis multiplex (HP:0000943)3.28875711
47Hepatic necrosis (HP:0002605)3.24954218
48Abnormality of mucopolysaccharide metabolism (HP:0011020)3.23570402
49Abnormality of polysaccharide metabolism (HP:0011012)3.23570402
50Abnormality of glycosaminoglycan metabolism (HP:0004371)3.23570402
51Dysautonomia (HP:0002459)3.22591144
52Bilateral microphthalmos (HP:0007633)3.18962010
53Alacrima (HP:0000522)3.16863145
54Decreased lacrimation (HP:0000633)3.16017086
55Facial cleft (HP:0002006)3.07702013
56Spastic diplegia (HP:0001264)3.07277127
57Absent radius (HP:0003974)3.06433514
58Large for gestational age (HP:0001520)3.01999003
59X-linked dominant inheritance (HP:0001423)3.01959675
60Birth length less than 3rd percentile (HP:0003561)3.00390290
61Increased hepatocellular lipid droplets (HP:0006565)2.98969651
62Short chin (HP:0000331)2.98608815
63Aplasia/Hypoplasia of the fovea (HP:0008060)2.98471308
64Hypoplasia of the fovea (HP:0007750)2.98471308
65Broad alveolar ridges (HP:0000187)2.94864069
66Lactic acidosis (HP:0003128)2.91723102
67Abnormality of male internal genitalia (HP:0000022)2.89843435
68Congenital hip dislocation (HP:0001374)2.89125715
69Abnormality of the aortic arch (HP:0012303)2.88173473
70Absent forearm bone (HP:0003953)2.87728574
71Aplasia involving forearm bones (HP:0009822)2.87728574
72Respiratory failure (HP:0002878)2.86774675
73Decreased activity of mitochondrial respiratory chain (HP:0008972)2.84900085
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.84900085
75Volvulus (HP:0002580)2.84741961
76Carpal bone hypoplasia (HP:0001498)2.79304294
77Premature skin wrinkling (HP:0100678)2.69972688
78Increased serum lactate (HP:0002151)2.68755677
79Albinism (HP:0001022)2.67792437
80Hamartoma (HP:0010566)2.65959946
81Vertebral fusion (HP:0002948)2.64725307
82Supernumerary spleens (HP:0009799)2.64519579
83Abnormality of the fovea (HP:0000493)2.62263223
84Lipid accumulation in hepatocytes (HP:0006561)2.61403648
85Choanal stenosis (HP:0000452)2.59918735
86Hypotrichosis (HP:0001006)2.58257446
87Hypochromic anemia (HP:0001931)2.56336108
88Growth hormone excess (HP:0000845)2.55085649
89Squamous cell carcinoma (HP:0002860)2.54405283
90Increased serum pyruvate (HP:0003542)2.54219351
91Exercise intolerance (HP:0003546)2.53459474
92Patellar aplasia (HP:0006443)2.48860671
93Joint stiffness (HP:0001387)2.47561554
94Hyperglycinemia (HP:0002154)2.46959313
95Basal cell carcinoma (HP:0002671)2.46710369
96Absent thumb (HP:0009777)2.44829225
97Bifid uvula (HP:0000193)2.43714877
98Respiratory difficulties (HP:0002880)2.43282334
99Gastrointestinal atresia (HP:0002589)2.43235486
100Diaphragmatic weakness (HP:0009113)2.43056888
101Increased number of teeth (HP:0011069)2.42441011
102Aplasia/Hypoplasia of the patella (HP:0006498)2.42262364
103Abnormal number of incisors (HP:0011064)2.39323271
104Cerebral hypomyelination (HP:0006808)2.38342323
105Short 5th finger (HP:0009237)2.37706685
106Optic disc pallor (HP:0000543)2.37063170
107Colon cancer (HP:0003003)2.36562989
108Selective tooth agenesis (HP:0001592)2.36126726
109Meckel diverticulum (HP:0002245)2.33915963
110Hypotelorism (HP:0000601)2.33387351
111Abnormality of the pancreatic islet cells (HP:0006476)2.33156873
112Abnormality of endocrine pancreas physiology (HP:0012093)2.33156873
113Type I transferrin isoform profile (HP:0003642)2.32078265
114Capillary hemangiomas (HP:0005306)2.30346778
115Aplasia of the musculature (HP:0100854)2.30163286
116Hypokinesia (HP:0002375)2.29530712
117Bowed forearm bones (HP:0003956)2.28325030
118Bowing of the arm (HP:0006488)2.28325030
119Testicular atrophy (HP:0000029)2.23403121
120Split hand (HP:0001171)2.22056511
121Clumsiness (HP:0002312)2.21931280
122Increased intramyocellular lipid droplets (HP:0012240)2.20823075
123Premature graying of hair (HP:0002216)2.20514907
124Broad-based gait (HP:0002136)2.20173442
125Nasal speech (HP:0001611)2.20040679
126Sparse eyelashes (HP:0000653)2.18193282
127Decreased muscle mass (HP:0003199)2.18178247
128Polycythemia (HP:0001901)2.18142115
129Lower limb hyperreflexia (HP:0002395)2.17396816
130Popliteal pterygium (HP:0009756)2.17338349
131Rough bone trabeculation (HP:0100670)2.16676276
132Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.14854561
133Abnormality of the ileum (HP:0001549)2.12678696
134Asymmetric septal hypertrophy (HP:0001670)2.12196043
135Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10957896
136Cerebral aneurysm (HP:0004944)2.10850858
137Narrow nasal bridge (HP:0000446)2.10413882
138Abnormality of glycolysis (HP:0004366)2.10179158
139Anal atresia (HP:0002023)2.10112606
140Abnormality of the labia minora (HP:0012880)2.10053224
141CNS demyelination (HP:0007305)2.09430355
142Lethargy (HP:0001254)2.08390920
143Hypoplastic pelvis (HP:0008839)2.08357136
144Renal Fanconi syndrome (HP:0001994)2.07847203
145Abnormality of the preputium (HP:0100587)2.03312015
146Stenosis of the external auditory canal (HP:0000402)2.03264473
147Broad thumb (HP:0011304)2.02859260
148Horseshoe kidney (HP:0000085)2.02342494
149Hemivertebrae (HP:0002937)2.00931414
150Chromsome breakage (HP:0040012)2.00928686
151Ectopic anus (HP:0004397)2.00911947
152Abnormal lung lobation (HP:0002101)2.00392043
153Premature ovarian failure (HP:0008209)1.99362857
154Aplasia/Hypoplasia involving the musculature (HP:0001460)1.96652626
155Astrocytoma (HP:0009592)1.96557977
156Abnormality of the astrocytes (HP:0100707)1.96557977
157Poor suck (HP:0002033)1.95736571
158Nausea (HP:0002018)1.95550607
159Congenital ichthyosiform erythroderma (HP:0007431)1.95060791
160Amelogenesis imperfecta (HP:0000705)1.94717536
161Methylmalonic aciduria (HP:0012120)1.94715629
162Reticulocytopenia (HP:0001896)1.94292749
163Abnormality of serum amino acid levels (HP:0003112)1.94196881
164Hypoplasia of the radius (HP:0002984)1.93736898
165Microretrognathia (HP:0000308)1.93353883
166Carpal synostosis (HP:0009702)1.92688530
167Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92447521
168Abnormal protein N-linked glycosylation (HP:0012347)1.92447521
169Abnormal protein glycosylation (HP:0012346)1.92447521
170Abnormal glycosylation (HP:0012345)1.92447521
171IgA deficiency (HP:0002720)1.91783506
172Spinal muscular atrophy (HP:0007269)1.90816218
173Menstrual irregularities (HP:0000858)1.89496011
174Hyperglycinuria (HP:0003108)1.89280470
175Preaxial foot polydactyly (HP:0001841)1.89280188
176Aplasia/Hypoplasia of the macula (HP:0008059)1.89194107
177Broad toe (HP:0001837)1.88534897
178Aplasia/Hypoplasia of the uvula (HP:0010293)1.88481752
179Oral leukoplakia (HP:0002745)1.87764110
180Abnormality of glycine metabolism (HP:0010895)1.87590566
181Abnormality of serine family amino acid metabolism (HP:0010894)1.87590566
182Amniotic constriction ring (HP:0009775)1.87559431
183Abnormality of placental membranes (HP:0011409)1.87559431
184Abnormality of the septum pellucidum (HP:0007375)1.87447035
185Restlessness (HP:0000711)1.86263326
186Bifid tongue (HP:0010297)1.84510920
187Short middle phalanx of the 5th finger (HP:0004220)1.80303908
188Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79458847
189Asplenia (HP:0001746)1.79258711
190Abnormality of the anterior horn cell (HP:0006802)1.78921427
191Degeneration of anterior horn cells (HP:0002398)1.78921427
192Generalized aminoaciduria (HP:0002909)1.78689237
193Neoplasm of the adrenal gland (HP:0100631)1.78586680
194Blindness (HP:0000618)1.76446411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.68693934
2ICK5.90772381
3DDR24.88371504
4MAP3K64.34396929
5STK164.23384785
6VRK24.21024521
7SRPK13.76634208
8BUB13.64748325
9PBK3.44326989
10MAP3K113.25234157
11NME13.21727753
12PINK13.13820370
13TYRO33.01054582
14FGR2.91076433
15MATK2.86432602
16TSSK62.77804032
17NME22.59339030
18UHMK12.54131757
19PDK22.46712584
20DAPK12.34954626
21KDR2.32452620
22PDGFRA2.32102747
23BRSK22.27980407
24CSK2.26597256
25MKNK22.25594626
26BMX2.21418902
27PLK32.18440599
28EIF2AK32.15451302
29PRKD22.11106535
30YES12.04626066
31PIM22.01081000
32MST41.95424689
33DYRK1B1.91028104
34PAK41.86600717
35BRSK11.81924408
36EIF2AK11.79184439
37VRK11.76726806
38TNIK1.76257152
39TESK21.73089477
40LATS21.71691517
41AKT31.70456333
42WNK31.68266681
43MKNK11.65939604
44TAF11.65044087
45CDK71.63043469
46CDK61.43145851
47MAP4K21.38413461
48CDK191.31468640
49TRPM71.29522916
50PLK21.24198562
51ABL21.22596467
52CDC42BPA1.21728636
53RPS6KC11.20212726
54RPS6KL11.20212726
55SMG11.17481502
56PIM11.16334447
57PRPF4B1.14848187
58OXSR11.14337889
59MAP3K101.13474982
60CSNK1G31.12952634
61GSK3A1.08875596
62PLK41.08024179
63ZAK1.07794846
64PHKG11.07699681
65PHKG21.07699681
66STK41.06662010
67HIPK21.03599060
68RPS6KA61.02187496
69CDK120.95344194
70NUAK10.94248294
71CHEK20.93075410
72CSNK1G20.92031019
73MAPK110.91644256
74EIF2AK20.90305072
75CSNK1A1L0.89431832
76TAOK20.88904067
77WEE10.88709574
78RPS6KA40.87450986
79CDK90.84861751
80DYRK30.82275801
81NEK10.76370800
82MTOR0.75095510
83PLK10.75095389
84RPS6KA50.72255417
85PRKAA10.67508702
86TYK20.63581436
87RPS6KA10.62862854
88ERBB30.62430509
89STK240.62425020
90TIE10.56089229
91GRK50.54612603
92PDGFRB0.54156156
93FLT30.49995684
94CDK20.47196480
95GRK10.47104364
96ATR0.47028773
97FER0.46278187
98MAP3K80.46242410
99RAF10.46027021
100BCKDK0.44621029
101LIMK10.44600593
102ALK0.43964520
103RPS6KB20.43699844
104EGFR0.42883158
105LATS10.42836729
106TESK10.42705444
107NLK0.41914874
108CSNK2A10.40378105
109LRRK20.40065784
110RPS6KB10.39363403
111CAMK2B0.39232092
112STK100.37773521
113PTK20.37693411
114CSNK1G10.37358565
115MAPK100.36381029
116STK30.36307755
117CAMK2G0.34949312
118PRKG20.34628365
119CDC70.34379083
120MAPK10.34183578
121ERBB40.34108492
122TRIM280.34080375
123MELK0.33536497
124MAPK140.32666308
125LYN0.31971311
126TRIB30.31551570
127MAPK30.31460314
128CSNK1A10.31418241
129ATM0.30184014
130EPHA20.29827569
131PAK10.29271345
132AKT20.28752534
133CHEK10.28494645
134AURKA0.27536361
135PRKAA20.26698958
136STK390.26668952
137DYRK20.26507844
138INSR0.26086926
139CDK10.26061967
140CSNK2A20.25174178
141RIPK10.24297132
142TEC0.24112890
143FGFR10.23841074
144PRKCI0.23771242
145CDK140.22879635
146INSRR0.22347031
147PAK20.22012126
148PASK0.21514559
149PRKCG0.21508926
150MAPK40.20968830
151CAMK2D0.20924157
152SGK10.20002197
153STK380.18926044
154TTK0.18738709
155PRKCZ0.18646513
156CDK180.18501956
157CAMK2A0.18484041
158GSK3B0.18020078
159RPS6KA30.17260088
160CDK150.16913991
161CDK40.16839251
162CDK11A0.16571440
163AKT10.16029401
164PRKDC0.15833912
165NEK20.15295876
166MAPKAPK20.15064484
167MAP3K90.14826125
168PRKD10.14802644
169MAPK90.12801083
170PRKACG0.11477938
171CSNK1E0.11369682
172AURKB0.11244310
173STK38L0.11073850

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030506.68821046
2Fatty acid biosynthesis_Homo sapiens_hsa000615.70276163
3Mismatch repair_Homo sapiens_hsa034304.75953296
4Base excision repair_Homo sapiens_hsa034104.47876290
5RNA polymerase_Homo sapiens_hsa030203.71091191
6DNA replication_Homo sapiens_hsa030303.31884423
7Oxidative phosphorylation_Homo sapiens_hsa001903.21705793
8Parkinsons disease_Homo sapiens_hsa050123.04851493
9Hedgehog signaling pathway_Homo sapiens_hsa043402.58086339
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.41125097
11Huntingtons disease_Homo sapiens_hsa050162.36746799
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.30648222
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.30385668
14Circadian rhythm_Homo sapiens_hsa047102.30373308
15Nucleotide excision repair_Homo sapiens_hsa034202.25240180
16Non-homologous end-joining_Homo sapiens_hsa034502.19560604
17Hippo signaling pathway_Homo sapiens_hsa043902.17631986
18Ribosome_Homo sapiens_hsa030102.17282196
19mRNA surveillance pathway_Homo sapiens_hsa030152.15892761
20Pyrimidine metabolism_Homo sapiens_hsa002402.11208943
21mTOR signaling pathway_Homo sapiens_hsa041502.10871823
22Arginine and proline metabolism_Homo sapiens_hsa003302.07574759
23Spliceosome_Homo sapiens_hsa030402.06701842
24Notch signaling pathway_Homo sapiens_hsa043302.04821405
25Alzheimers disease_Homo sapiens_hsa050102.01997004
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.01882351
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00774608
28RNA transport_Homo sapiens_hsa030131.92632957
29Basal cell carcinoma_Homo sapiens_hsa052171.73499202
30Protein export_Homo sapiens_hsa030601.73011448
31Adherens junction_Homo sapiens_hsa045201.70630588
32Biosynthesis of amino acids_Homo sapiens_hsa012301.68877617
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.58001224
34Folate biosynthesis_Homo sapiens_hsa007901.57109370
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53619311
36Homologous recombination_Homo sapiens_hsa034401.52722501
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50173212
38Fatty acid metabolism_Homo sapiens_hsa012121.48954174
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47236457
40Fanconi anemia pathway_Homo sapiens_hsa034601.44052568
41Pyruvate metabolism_Homo sapiens_hsa006201.42898011
42Longevity regulating pathway - mammal_Homo sapiens_hsa042111.41548138
43Wnt signaling pathway_Homo sapiens_hsa043101.41271516
44TGF-beta signaling pathway_Homo sapiens_hsa043501.41256788
45Purine metabolism_Homo sapiens_hsa002301.39091849
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38842218
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38213838
48Lysine degradation_Homo sapiens_hsa003101.36432298
49p53 signaling pathway_Homo sapiens_hsa041151.34629870
50Sulfur relay system_Homo sapiens_hsa041221.31729545
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30798182
52Bladder cancer_Homo sapiens_hsa052191.29557316
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25889305
54Cell cycle_Homo sapiens_hsa041101.20257671
55Arginine biosynthesis_Homo sapiens_hsa002201.11174979
56Cardiac muscle contraction_Homo sapiens_hsa042601.08142985
57Fructose and mannose metabolism_Homo sapiens_hsa000511.07466584
58Propanoate metabolism_Homo sapiens_hsa006401.07139629
59Carbon metabolism_Homo sapiens_hsa012001.05981433
60Glycosaminoglycan degradation_Homo sapiens_hsa005311.03771564
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03128048
62Shigellosis_Homo sapiens_hsa051310.93891266
63Oocyte meiosis_Homo sapiens_hsa041140.93312083
64beta-Alanine metabolism_Homo sapiens_hsa004100.90520067
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90376262
66VEGF signaling pathway_Homo sapiens_hsa043700.86477065
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83700737
68Dorso-ventral axis formation_Homo sapiens_hsa043200.80891826
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80006844
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79956191
71Colorectal cancer_Homo sapiens_hsa052100.79163622
72MicroRNAs in cancer_Homo sapiens_hsa052060.76511862
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74897345
74Epstein-Barr virus infection_Homo sapiens_hsa051690.73182907
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72041874
76Tight junction_Homo sapiens_hsa045300.71971471
77Metabolic pathways_Homo sapiens_hsa011000.71210987
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68069818
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.67535200
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64730205
81Legionellosis_Homo sapiens_hsa051340.64302033
82Galactose metabolism_Homo sapiens_hsa000520.63454184
83ErbB signaling pathway_Homo sapiens_hsa040120.62575591
84Phenylalanine metabolism_Homo sapiens_hsa003600.62362792
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61154369
86AMPK signaling pathway_Homo sapiens_hsa041520.60937636
87Thyroid cancer_Homo sapiens_hsa052160.60390686
88Viral myocarditis_Homo sapiens_hsa054160.59217036
89Steroid biosynthesis_Homo sapiens_hsa001000.59053523
90Choline metabolism in cancer_Homo sapiens_hsa052310.58717558
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56921206
92Gap junction_Homo sapiens_hsa045400.54656279
93Insulin signaling pathway_Homo sapiens_hsa049100.53949440
94Selenocompound metabolism_Homo sapiens_hsa004500.52743949
95Vitamin B6 metabolism_Homo sapiens_hsa007500.50431436
96Chronic myeloid leukemia_Homo sapiens_hsa052200.46949837
97One carbon pool by folate_Homo sapiens_hsa006700.46783457
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45707534
99Peroxisome_Homo sapiens_hsa041460.45585241
100Proteoglycans in cancer_Homo sapiens_hsa052050.44734660
101Phototransduction_Homo sapiens_hsa047440.44057704
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43187962
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42522815
104Tryptophan metabolism_Homo sapiens_hsa003800.42350714
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39127608
106Acute myeloid leukemia_Homo sapiens_hsa052210.38951899
107Tyrosine metabolism_Homo sapiens_hsa003500.37807772
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.35956361
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33311351
110Endometrial cancer_Homo sapiens_hsa052130.32924021
111Pentose phosphate pathway_Homo sapiens_hsa000300.32849521
112Viral carcinogenesis_Homo sapiens_hsa052030.31691521
113Glutathione metabolism_Homo sapiens_hsa004800.31460989
114Primary immunodeficiency_Homo sapiens_hsa053400.31414196
115RNA degradation_Homo sapiens_hsa030180.30146494
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30078593
117Histidine metabolism_Homo sapiens_hsa003400.29852846
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29600073
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29593292
120Sulfur metabolism_Homo sapiens_hsa009200.28624537
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28340564
122Small cell lung cancer_Homo sapiens_hsa052220.27817052
123Retinol metabolism_Homo sapiens_hsa008300.27218902
124MAPK signaling pathway_Homo sapiens_hsa040100.26756033
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26397150
126Systemic lupus erythematosus_Homo sapiens_hsa053220.25996074
127Prostate cancer_Homo sapiens_hsa052150.25898345
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25742140
129Fatty acid degradation_Homo sapiens_hsa000710.24523166
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23430530
131Glucagon signaling pathway_Homo sapiens_hsa049220.22074363
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21949879
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21717740
134Collecting duct acid secretion_Homo sapiens_hsa049660.21537574
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20545849
136Fatty acid elongation_Homo sapiens_hsa000620.20243384
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.19138325
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.18746010
139Pathways in cancer_Homo sapiens_hsa052000.18438781
140Vitamin digestion and absorption_Homo sapiens_hsa049770.18295940
141Prion diseases_Homo sapiens_hsa050200.18120478
142HTLV-I infection_Homo sapiens_hsa051660.17628829
143Lysosome_Homo sapiens_hsa041420.17202953
144Estrogen signaling pathway_Homo sapiens_hsa049150.17143986
145Mineral absorption_Homo sapiens_hsa049780.14828358
146Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13990070
147Chemical carcinogenesis_Homo sapiens_hsa052040.13331635
148Basal transcription factors_Homo sapiens_hsa030220.13032920
149Melanogenesis_Homo sapiens_hsa049160.12832852
150Focal adhesion_Homo sapiens_hsa045100.11265392
151N-Glycan biosynthesis_Homo sapiens_hsa005100.10994744
152Starch and sucrose metabolism_Homo sapiens_hsa005000.10919061
153Herpes simplex infection_Homo sapiens_hsa051680.08748843
154Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.06067552
155Renin-angiotensin system_Homo sapiens_hsa046140.05062968

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